38 results about "Tissue material" patented technology

The invention relates to the technical field of bioengineering, in particular to a recombinant VII type collagen for inhibiting scars as well as a preparation method and application of the recombinant VII type collagen. The amino acid sequence of the recombinant VII type collagen is as shown in SEQ ID NO. 1. The recombinant VII type collagen provided by the invention has a better cell adhesion function, so that the recombinant VII type collagen can be applied to the fields of preparation of tissue materials, wound dressings and the like. Meanwhile, the VII type collagen does not contain any tag or exogenous amino acid sequence, is a completely humanized sequence, and does not generate immune response. The VII type collagen has a good adhesion effect, the adhesion effect is better than that of other recombinant collagen, the adhesion effect is equivalent to that of a common cell adhesive in the market, scars can be reduced by inhibiting activation of a TGF-beta pathway, and the VII type collagen can be developed into skin care products and medical instruments for promoting traceless wound repair and has a wide application prospect.

The invention provides a structure and a production process of a wet tissue material and a sanitary towel liquid absorption material in the hygienic product industry, and relates to the technical field of hygienic products, the structure comprises a first hydrophilic solvent layer, a first PP melt-blown material layer, a middle functional layer and a second PP melt-blown material layer which are arranged in sequence, and a second hydrophilic solvent layer is further arranged on the outer side of the second PP melt-blown material layer; when the material is a sanitary towel liquid absorption material, the middle functional layer is a mixed layer of a PP melt-blown material, wood pulp and macromolecules; when the material is a wet tissue material, the middle functional layer is a mixed layer of a PP melt-blown material and wood pulp, the proportion of the raw materials can be adjusted, and the middle functional layer is used for manufacturing products such as urine pads, kitchen dry tissues, pet pads and dust-free paper; through the composite structure design of the PP melt-blown material and the wood pulp / wood pulp-macromolecules and the hydrophilic modification treatment of the outer layer, the overall tensile strength is effectively enhanced, and the problem of tearing or layering in use is avoided; the material softness is improved, and the material is more fit and comfortable; the moisture retention performance and the liquid absorption diffusion speed of the material are optimized, it is guaranteed that the wet tissue can keep moist for a long time, and the sanitary towel can rapidly and evenly absorb liquid.

The invention provides a dose determination method, device and system based on Monte Carlo beam modeling, and relates to the field of physics and computers, in particular to application of physics and computer technologies in the field of radiation medical treatment. The method comprises the steps that multiple pieces of target data are obtained, and the target data are obtained based on actual measurement and used for describing the characteristics of a particle beam transmitted by target equipment; at least part of source parameters in the original model are subjected to reverse optimization based on the multiple pieces of target data, target parameters and a target model containing the target parameters are obtained, and the source parameters are input data of the original model and used for describing the initial state of the particle beam before the particle beam enters the tissue material; and determining a target dose based on the target model.

A flexible auger design for low-torque transmitting drive shafts, which allows effective tissue material transport through curved, flexible tubes and channels. A hollow auger has a hollow center, so that the helical member hugs the inner wall of the tube and material is transported along the center axis and the inner wall of the tube. The hollow flexible auger allows for transportation of material from an operative location in the patient (material removal) as well as to operative location in the patient (material delivery).

This invention provides a method for rapid extraction of collagen, belonging to the field of regenerative medicine technology. The method includes the following steps: (1) taking animal tissue material as the extraction raw material, crushing it to remove fat and impurities, and obtaining a precipitate; (2) placing the precipitate into a molding mold to obtain a tissue module, freezing and storing the tissue module to obtain a pretreated material; (3) mixing an acidic aqueous solution and pepsin to obtain an extract; placing the pretreated material in the extract in a suspended state, first allowing it to stand and then extracting it in suspension, then stirring, filtering or centrifuging, and retaining the supernatant to obtain a crude extract; (4) adding inorganic salts to the crude extract, allowing it to stand, filtering, collecting the precipitate, washing it, and then transferring the precipitate into a buffer solution to swell it. Filtering the swollen precipitate and dialyzing it to obtain a collagen aqueous solution, followed by post-processing to obtain collagen. The method for extracting collagen provided by this invention can significantly shorten the extraction time.

The application relates to a kind of experimental material grinding equipment for biological experiment, belong to biological experiment equipment technical field, including base and the rotary power part being set on base, mortar is fixed on base, grinding head coaxial setting in mortar, the head of grinding head is opened with guide slot along its radial profile direction, flexible band is worn in guide slot, flexible band is provided with friction structure along its longitudinal direction, drive assembly includes two limit tubes and linear displacement mechanism, two limit tubes are fixed on grinding head, flexible band extends to corresponding limit tube in slide groove, the displacement output end of linear displacement mechanism is connected with both ends of flexible band, the application utilizes mortar, grinding head to carry out extrusion grinding, can drive flexible band reciprocating movement along guide slot simultaneously, so that friction structure is contacted with the friction force of biological tissue material along the radial direction of grinding head to the friction structure, realize the turning of biological tissue material, avoid the temperature of tissue material to be too high and cause the inactivation of target substance released.

The invention provides a multi-ion Monte Carlo dose calculation method, a multi-ion Monte Carlo dose calculation device and electronic equipment, which can be applied to the fields of physics and computers. The method comprises the following steps: simulating a transportation process of a plurality of main particles of a current batch in a tissue material to obtain transportation results of the plurality of main particles; wherein the main particles in different batches are the same or different; index information is constructed on the basis of the main particles and the tissue materials, secondary particles generated by the main particles in the transportation process are obtained through sampling from a preset database by means of the index information, and the preset database comprises feature distribution information of the multi-source secondary particles; pressing the secondary particles into the corresponding secondary particle stacks, and calculating the transport result of each secondary particle in the secondary particle stacks in the tissue material by using a specified thread of the GPU; and determining the Monte Carlo dosage of the target ions according to the transport result of the main particles and the transport result of the secondary particles.

A system for harvesting bone material from a bone may include a rotary cutter defining a rotary cutter longitudinal axis extending between a rotary cutter proximal end and a rotary cutter distal end. The rotary cutter may have a drive shaft configured to receive input torque, and an osteochondral cutter configured to cut the tissue and receive the tissue material in response to rotation of the osteochondral cutter under pressure against the tissue. The system may further include a bone port defining a bone port longitudinal axis extending between a bone port proximal end and a bone port distal end. The bone port may have a bone port cannulation sized to closely fit over the osteochondral cutter. At least one of the bone port proximal end and the bone port distal end may be securable to the tissue. A stratiform tissue graft may be delivered through the bone port.

The present application relates to the technical field of bioengineering, and particularly relates to a recombinant type VII collagen for inhibiting scar, and a preparation method and application thereof. The amino acid sequence of the recombinant type VII collagen is shown as SEQ ID NO. 1. The recombinant type VII collagen has good cell adhesion function, and thus can be applied to the fields of preparing tissue materials and wound dressings. Meanwhile, the type VII collagen does not contain any label and exogenous amino acid sequence, is a completely humanized sequence, and will not produce an immune response. The type VII collagen has good adhesion effect, and the adhesion effect is superior to other recombinant collagens, is equivalent to the adhesion effect of a commonly used cell adhesion agent on the market, and can reduce scar production by inhibiting the activation of a TGF-beta pathway. The type VII collagen can be developed into skin care products and medical devices for promoting non-scar wound repair, and has a wide application prospect.

The application relates to the field of biomaterials, and particularly discloses a kind of acellular matrix material and a preparation method thereof.The preparation method of the material comprises the following steps: extracting tissue material of a mammal, performing acellular treatment on the tissue material to obtain acellular tissue material, freeze-drying the tissue material, and then crushing the freeze-dried tissue material to obtain animal-derived acellular matrix; the animal-derived acellular matrix is resuspended in water, mixed with a modified epoxidized chitosan solution, and then transglutaminase is added to perform a reaction; the product obtained is freeze-dried to obtain the acellular matrix material.The method can improve the biocompatibility of the acellular matrix and reduce the immune rejection reaction by cross-linking the animal-derived acellular matrix with modified epoxidized chitosan; at the same time, since the cross-linking reaction is a biological cross-linking reaction under the action of transglutaminase, the biological activity factors contained in the acellular matrix are not easily destroyed during the cross-linking process, and the biological activity and safety are better.

This invention relates to a method, device, and medium for displaying mechanical information for risk warning during impacted tooth extraction. The method includes: Step S1: Obtaining the three-dimensional modeling results of each tissue unit; Step S2: Obtaining the modeling results of each tooth segment unit; Step S3: Constructing the tooth segment and its contact constraints with surrounding tissues; Step S4: Based on the constructed contact constraints, combined with the overall finite element stiffness matrix and operational load, solving for the displacement response of each finite element mesh; Step S5: Based on the displacement response of each finite element mesh and the shape function, obtaining the displacement matrix of each element, and further obtaining the strain tensor of each element; Step S6: Based on the constitutive matrix of the tissue material corresponding to each element and the strain tensor, obtaining the stress tensor of each element; Step S7: Comparing the stress tensor of each element with its pre-configured threshold and assigning color values ​​to the finite element mesh of each element. Compared with the prior art, this invention has the advantages of real-time performance and high accuracy.

Disclosed herein are methods of analyzing a tissue sample using quantitative phase contrast microscopy, as well as corresponding microfluidic systems and corresponding devices. The methods include providing the tissue sample in a sample volume of a microfluidic system, wherein the tissue sample includes a plurality of biological cells forming a continuous tissue material. At least a portion of the tissue sample is lysed into single cells and / or cell aggregates in a carrier fluid in the sample volume. A carrier fluid flow is generated from the sample volume to a measurement volume of the microfluidic system, and a first phase shift image of the single cells and / or cell aggregates in the measurement volume is acquired with a quantitative phase contrast microscope.

The invention provides a method for rapidly transferring pleione bulbocodioides after sterile sowing, and relates to the technical field of tissue culture, the method comprises the following steps: providing pleione bulbocodioides pods; providing a primary culture medium; carrying out pod sowing and primary culture; subculture transfer: pouring the primary culture medium full of the protocorms into a device containing a subculture medium, and spreading the primary culture medium. According to the method, the transfer of the subculture is completed by pouring and sub-packaging, so that the waste of a primary culture medium is avoided, the time required by the transfer of the subculture tissue material is shortened, the time cost of seedling production is effectively reduced, and meanwhile, the yellowing or differentiation blocking of protocorm caused by deterioration of a microenvironment in a tissue culture bottle due to an overlong transfer period is avoided; the subsequent seedling production quality is improved; compared with a traditional mode of transferring by using tweezers, the method has the advantages that the time of exposing the tissue material in an environment outside a bottle is greatly shortened, and the pollution rate of the tissue material is effectively reduced.

The invention discloses application of an acellular matrix material as a tissue damage or tumor targeting probe or carrier. A preparation method of the acellular matrix material comprises the following steps: pretreating fish tissues; performing decellularization treatment on the pretreated fish tissue to obtain a decellularized fish tissue material; the preparation method comprises the following steps: freeze-drying, grinding and digesting the decellularized fish tissue material, then carrying out ultrafiltration and centrifugation to intercept filtrate with the molecular weight of less than 50KDa, and freeze-drying to obtain the decellularized matrix material. The acellular matrix material disclosed by the invention has good blood compatibility and has a targeting effect on tissue injury, especially myocardial injury parts, diabetic nephropathy tissues or tumors.

A tissue dispenser features a main housing to removably receive tissue material and a sensor housing mounted via a specialized mechanism. This mechanism includes an actuating mechanism actuable in a locked and unlocked state to release the sensor housing. The sensor housing detects tissue depletion, unauthorized access, and operational status, sending relevant notifications. This ensures timely maintenance and security. The design allows for easy replacement of tissue material and the sensor housing, making it ideal for various environments. The system enhances convenience and operational efficiency, offering automated control and reducing manual intervention.

The present application relates to a dose evaluation method, an irradiation condition selection method and a treatment plan generation apparatus. The dose evaluation method comprises: acquiring tissue material information; determining a conjugate flux corresponding to a tissue material according to the tissue material information; and on the basis of an irradiation condition in combination with the conjugate flux corresponding to the tissue material, obtaining a radiation absorption dose corresponding to the tissue material under the irradiation condition. By using the method, a radiation absorption dose corresponding to a tissue material can be quickly calculated, thereby improving the efficiency of dose calculation under a plurality of irradiation conditions, and radiation absorption doses corresponding to each tissue material under different irradiation conditions can be quickly evaluated, so as to facilitate the quick selection of a suitable irradiation condition from among the plurality of irradiation conditions, thereby greatly shortening the formulation time of a treatment plan.

The present application discloses a kind of prosthesis with elastic pipeline and its manufacturing method, manufacturing method includes: according to the three-dimensional image of organ, the first tissue mold and the second tissue mold with elasticity are made;First false tissue material is coated on the surface of the first tissue mold, and the first false tissue with closed end and elasticity is made;The first false tissue is correctly positioned in the second tissue mold;Gelatinous second false tissue material is injected into the second tissue mold, and the first false tissue is covered;The interior of the first false tissue has first pressure value;Negative pressure defoaming step is applied to the second false tissue material;Freezing and thawing step is applied to the second false tissue material, to be shaped as second false tissue, in the thawing process in the freezing and thawing step, the interior of the first false tissue is repeatedly applied to decompression and pressurization step, and the decompression and pressurization step is executed below the first pressure value;The second tissue mold is removed, and the manufacturing of the prosthesis with elastic pipeline is completed.

A device for real-time monitoring of liquid absorbance and swelling characteristics of soft-tissue materials is provided herein. The device includes a microfluidics circuit configured to monitor volumetric changes in fluids pumped through the circuit, a sample chamber assembly for holding a sample of the soft-tissue material, a flow chamber assembly connected to the microfluidics circuit and the sample chamber assembly, a flow sensor positioned within the microfluidics circuit and configured to measure flow rate of fluids passing through the circuit, and a control system configured to control the microfluidics circuit and to collect data related to the volumetric changes in the fluids and the swelling characteristics of the soft-tissue material.

The invention relates to a preparation method and application of a gentamicin sulfate acellular matrix bacteriostatic slice, and the preparation method comprises the following steps: S1, taking an animal skin material, degreasing, washing and cutting to obtain a tissue material; s2, immersing the tissue material in sterile water for multiple times of ultrasonic cleaning, and then adding the tissue material into a cleaning solution for multiple times of soaking and cleaning to obtain a decellularized tissue; s3, freeze-drying the decellularized tissue, and grinding at-20 to 0 DEG C to obtain decellularized matrix powder; s4, adding the acellular matrix powder, collagen powder and gentamicin sulfate into normal saline, and uniformly mixing to obtain composite gel; and S5, pouring the composite gel into a mold, spreading the composite gel, performing pre-compression molding, and performing freeze-drying to obtain the gentamicin sulfate acellular matrix antibacterial slice. The acellular matrix treated by combining a physical means and a chemical means is cooperated with the collagen and gentamicin sulfate, so that the antibacterial sheet has the effects of high biocompatibility, long-acting and stable antibacterial effect and excellent mechanical property.

A method for constructing a personalized human eye model. This includes the following steps: (1) simplifying the structural parameters of the human eye to establish a personalized three-dimensional full-eye geometric model; (2) determining the viscoelastic material parameters of the human cornea; (3) using fluid-structure interaction to simulate the actual boundary conditions of the human eye, analyzing the changes in the actual state of the human eye, selecting appropriate element types, discretizing the model into a finite number of aggregates, completing the construction of the finite element human eye model, and solving the model using finite elements; (4) simulating optical coherence elastography of the anterior segment tissues such as the cornea. Considering the individual differences in the geometric morphology and tissue material parameters of the human eye, based on clinical ophthalmological diagnostic data, a personalized full-eye model containing complete geometric morphological information of the human eye was established in finite element software using an elastography method, providing theoretical guidance and technical support for ocular tissue optical coherence elastography equipment.

A set of surgical instruments adapted to cut bone and tissue material to prepare a surgical site to receive a prosthesis. The kit includes a plurality of distal reamers including sub-kits having different diameters and a common axial length, and a corresponding plurality of sets of proximal reamers having different diameters and a common axial length. A fully modular instrument cutting assembly is provided to allow for transformations between different implant types intraoperatively.

The utility model discloses a pathological tissue embedding box relates to embedding box technical field, including box body and lid unit, and the top of box body left side wall is equipped with the lock hole, and the upper right side wall of box body is equipped with the clamping hook, and the left side of lid unit is equipped with the locking unit of detachable connection with the lock hole, the right side of lid unit is equipped with the connection rotating unit, and the connection rotating unit is detachably connected with the clamping hook, and can have relative rotation, and the middle position of box body inner chamber is equipped with the short torus, and the bottom wall of box body inner chamber located short torus outside evenly is equipped with a plurality of big penetration holes, and the bottom wall of box body inner chamber located short torus inside evenly is equipped with a plurality of small penetration holes, the utility model discloses box body and lid unit separate setting, can replace the lid unit of adaptation according to the specific application scene, and through locking unit and connection rotating unit realize quick installation, and it is convenient to adapt various pathological tissue material taking, and effectively improve pathological tissue material taking, embedding and the efficiency of section.

The utility model relates to the technical field of rodent nose tissue pathological specimen material taking, specifically discloses rodent nasal mucosa tissue material taking device, the one side of fixed plate is provided with first fixed clamping groove and second fixed clamping groove respectively, is provided with head container on the fixed plate, is provided with first clamping groove insertion port, second clamping groove insertion port and cutting knife clamping groove on head container respectively, and the one side of head container is provided with scale, the rodent nasal mucosa tissue material taking device whole simple structure, and the installation and use are convenient, and the material taking work of rodent nasal mucosa tissue of staff is convenient, since setting up the scale for measuring distance on the bottom plate, a plurality of graduation grooves are opened on the scale, the position of rodent head tissue is measured through the scale, is convenient for its accurate cutting, thereby help to improve the accuracy of rodent nasal mucosa tissue material taking.

There is a need in the art for synthetic tissue models that not only simulate the tactile properties of tissues and organs but further withstand and respond in an analogous fashion to the application of energy, particularly heat and electrical energy such as accompany electrosurgery. Described herein are materials and methods useful in the construction of synthetic tissue models, particularly conductive synthetic tissue materials made from a state-sensitive, cross-linked polymer composition, that have utility in connection with thermal treatment training and simulation exercises, and moreover provide a current controlled treatment field profile analogous to that of existing tissue to that of the present invention. To that end, the simulated tissues and anatomical models of the present invention are fabricated from a hydrogel composition that undergoes partial or complete transition from its native state prior to treatment (e.g., thermal or non-thermal treatment) to one or more other states when exposed to energy, including but not limited to the following state transitions: discoloration, denaturation, coagulation, carbonization, vaporization, melting or other energy-induced state transition. These transitions facilitate the generating and detecting of a lifelike treatment field profile.

Transport device (10) for at least one, in particular contamination-free, transport of at least one object to be transported between at least two different external environments, in particular for the transport of at least one container (20), in particular of at least one container (20) filled with a pharmaceutical product and / or a biological material, for example a genetic material and / or a cell culture and / or a tissue material, wherein the transport device (10) comprises at least one housing (120), wherein the housing (120) has at least two housing parts (130), a transport interior (121), an exchange opening (150) and a gas passage (140), wherein the housing (120) is designed to be variable into several states, wherein the several states comprise at least one open state, one closed state and one partially open state.wherein in the open state the at least one object to be transported can be inserted into and / or removed from the transport interior (121) through the exchange opening (150), wherein in the closed state the transport interior (121) is sealed by housing parts (130) of the housing (120), wherein in the partially open state the transport interior (121) is separated from the respective environment by housing parts (130) of the housing (120), but is connected to the respective environment by means of the gas passage (140) in a gas-permeable, in particular gas-permeable sterile, manner.

The present invention relates to a method for preparing a tissue repair material, comprising the steps of pretreatment, defatting, virus inactivation, decellularization, material recovery, freeze-drying, and sterilization. It also relates to a tissue repair material prepared by this method and its application. The method for preparing a tissue repair material provided by the present invention can effectively remove immunogenic substances from the material while better restoring the tensile strength and elasticity of the tissue material, thereby obtaining a bioscaffold material with improved biocompatibility, non-immunogenic cell attachment, proliferation, differentiation, and mechanical properties. The tissue repair material obtained by the method of the present invention has excellent efficacy in guiding cartilage regeneration.

The invention belongs to the technical field of pathogen collection, and particularly relates to a medical microorganism collection device which comprises an air pressure box, the air pressure box is hollow, a protective cover is fixedly connected to the top wall of the air pressure box, a placement box is fixedly connected to the top wall of the air pressure box, the placement box is arranged in the protective cover, and the placement box is hollow. The hollow part of the placing box communicates with the hollow part of the air pressure box, and the inner wall of the protective cover is slidably connected with a pushing plate. In the tissue placement process, the binding air bag is preliminarily expanded to pre-fix tissues, after the tissues are placed in place, the tissues in different shapes are fixed, triangular layout is formed for the tissues, the tissues are limited from multiple directions, shaking of the tissues during collection is effectively avoided, tissue fluid aggregation is promoted through regular extrusion, and the tissue fluid collection efficiency is improved. The collection success rate is increased, the tissue fluid can be conveniently collected, and pathogens in the tissue fluid can be subsequently analyzed and detected.

The present application relates to ascites drainage technical field, specifically, it relates to a kind of ascites drainage device for cirrhosis nursing, including the collection component for collecting ascites and the drainage tube component for draining ascites, and the drainage tube component is equipped with the clear block component for cleaning the tissue material blocked in the drainage tube component;Clear block component includes movable sleeve structure, extrusion structure, the pressing structure for triggering extrusion structure contraction extrusion and the press handle structure for pushing the pressing structure, which are movably sleeved on the drainage tube component;Movable sleeve structure includes barrel movable sleeve, mounting groove and pressing groove.The device is provided with clear block component, after the drainage tube is blocked by tissue material when cirrhosis patient is drained, medical staff can hold press handle structure to clear block, it is simple and convenient;After clearing block, through the cooperation of first magnetic buckle, first magnetic attraction slot and limiting bolt, the drainage tube can be further extruded and closed, reduce the infection risk caused by subsequent cleaning collection barrel.

The embodiment of the utility model discloses an embedding box for fixing pathological tissues, the embedding box is a box body, the box body comprises a box cover and a containing box detachably connected with the box cover, a plurality of partition plates are arranged in the containing box, and a plurality of containing grooves are formed; a plurality of through holes are formed in the bottoms of the box cover and the accommodating box; a pathological tissue fixing piece is arranged on the inner side of the box cover and corresponds to the upper part of the accommodating groove, and the pathological tissue fixing piece is matched with the bottom of the accommodating groove and can fix the pathological tissue in the accommodating groove. According to the embedding box for fixing the pathological tissue, the pathological tissue fixing pieces are correspondingly arranged in the containing groove, so that the direction of the pathological tissue of the pathological tissue is convenient to fix, pathological tissue materials are convenient to fully soak, and the position of the pathological tissue is convenient to identify; the diseased tissue part is easy to identify, the target diseased tissue is convenient to cut after paraffin embedding, and a good foundation is laid for accurate detection.