30 results about "Tissue material" patented technology

The invention relates to the technical field of bioengineering, in particular to a recombinant VII type collagen for inhibiting scars as well as a preparation method and application of the recombinant VII type collagen. The amino acid sequence of the recombinant VII type collagen is as shown in SEQ ID NO. 1. The recombinant VII type collagen provided by the invention has a better cell adhesion function, so that the recombinant VII type collagen can be applied to the fields of preparation of tissue materials, wound dressings and the like. Meanwhile, the VII type collagen does not contain any tag or exogenous amino acid sequence, is a completely humanized sequence, and does not generate immune response. The VII type collagen has a good adhesion effect, the adhesion effect is better than that of other recombinant collagen, the adhesion effect is equivalent to that of a common cell adhesive in the market, scars can be reduced by inhibiting activation of a TGF-beta pathway, and the VII type collagen can be developed into skin care products and medical instruments for promoting traceless wound repair and has a wide application prospect.

The invention provides a structure and a production process of a wet tissue material and a sanitary towel liquid absorption material in the hygienic product industry, and relates to the technical field of hygienic products, the structure comprises a first hydrophilic solvent layer, a first PP melt-blown material layer, a middle functional layer and a second PP melt-blown material layer which are arranged in sequence, and a second hydrophilic solvent layer is further arranged on the outer side of the second PP melt-blown material layer; when the material is a sanitary towel liquid absorption material, the middle functional layer is a mixed layer of a PP melt-blown material, wood pulp and macromolecules; when the material is a wet tissue material, the middle functional layer is a mixed layer of a PP melt-blown material and wood pulp, the proportion of the raw materials can be adjusted, and the middle functional layer is used for manufacturing products such as urine pads, kitchen dry tissues, pet pads and dust-free paper; through the composite structure design of the PP melt-blown material and the wood pulp / wood pulp-macromolecules and the hydrophilic modification treatment of the outer layer, the overall tensile strength is effectively enhanced, and the problem of tearing or layering in use is avoided; the material softness is improved, and the material is more fit and comfortable; the moisture retention performance and the liquid absorption diffusion speed of the material are optimized, it is guaranteed that the wet tissue can keep moist for a long time, and the sanitary towel can rapidly and evenly absorb liquid.

This invention provides a method for rapid extraction of collagen, belonging to the field of regenerative medicine technology. The method includes the following steps: (1) taking animal tissue material as the extraction raw material, crushing it to remove fat and impurities, and obtaining a precipitate; (2) placing the precipitate into a molding mold to obtain a tissue module, freezing and storing the tissue module to obtain a pretreated material; (3) mixing an acidic aqueous solution and pepsin to obtain an extract; placing the pretreated material in the extract in a suspended state, first allowing it to stand and then extracting it in suspension, then stirring, filtering or centrifuging, and retaining the supernatant to obtain a crude extract; (4) adding inorganic salts to the crude extract, allowing it to stand, filtering, collecting the precipitate, washing it, and then transferring the precipitate into a buffer solution to swell it. Filtering the swollen precipitate and dialyzing it to obtain a collagen aqueous solution, followed by post-processing to obtain collagen. The method for extracting collagen provided by this invention can significantly shorten the extraction time.

The application relates to a kind of experimental material grinding equipment for biological experiment, belong to biological experiment equipment technical field, including base and the rotary power part being set on base, mortar is fixed on base, grinding head coaxial setting in mortar, the head of grinding head is opened with guide slot along its radial profile direction, flexible band is worn in guide slot, flexible band is provided with friction structure along its longitudinal direction, drive assembly includes two limit tubes and linear displacement mechanism, two limit tubes are fixed on grinding head, flexible band extends to corresponding limit tube in slide groove, the displacement output end of linear displacement mechanism is connected with both ends of flexible band, the application utilizes mortar, grinding head to carry out extrusion grinding, can drive flexible band reciprocating movement along guide slot simultaneously, so that friction structure is contacted with the friction force of biological tissue material along the radial direction of grinding head to the friction structure, realize the turning of biological tissue material, avoid the temperature of tissue material to be too high and cause the inactivation of target substance released.

A system for harvesting bone material from a bone may include a rotary cutter defining a rotary cutter longitudinal axis extending between a rotary cutter proximal end and a rotary cutter distal end. The rotary cutter may have a drive shaft configured to receive input torque, and an osteochondral cutter configured to cut the tissue and receive the tissue material in response to rotation of the osteochondral cutter under pressure against the tissue. The system may further include a bone port defining a bone port longitudinal axis extending between a bone port proximal end and a bone port distal end. The bone port may have a bone port cannulation sized to closely fit over the osteochondral cutter. At least one of the bone port proximal end and the bone port distal end may be securable to the tissue. A stratiform tissue graft may be delivered through the bone port.

The present application relates to the technical field of bioengineering, and particularly relates to a recombinant type VII collagen for inhibiting scar, and a preparation method and application thereof. The amino acid sequence of the recombinant type VII collagen is shown as SEQ ID NO. 1. The recombinant type VII collagen has good cell adhesion function, and thus can be applied to the fields of preparing tissue materials and wound dressings. Meanwhile, the type VII collagen does not contain any label and exogenous amino acid sequence, is a completely humanized sequence, and will not produce an immune response. The type VII collagen has good adhesion effect, and the adhesion effect is superior to other recombinant collagens, is equivalent to the adhesion effect of a commonly used cell adhesion agent on the market, and can reduce scar production by inhibiting the activation of a TGF-beta pathway. The type VII collagen can be developed into skin care products and medical devices for promoting non-scar wound repair, and has a wide application prospect.

This invention relates to a method, device, and medium for displaying mechanical information for risk warning during impacted tooth extraction. The method includes: Step S1: Obtaining the three-dimensional modeling results of each tissue unit; Step S2: Obtaining the modeling results of each tooth segment unit; Step S3: Constructing the tooth segment and its contact constraints with surrounding tissues; Step S4: Based on the constructed contact constraints, combined with the overall finite element stiffness matrix and operational load, solving for the displacement response of each finite element mesh; Step S5: Based on the displacement response of each finite element mesh and the shape function, obtaining the displacement matrix of each element, and further obtaining the strain tensor of each element; Step S6: Based on the constitutive matrix of the tissue material corresponding to each element and the strain tensor, obtaining the stress tensor of each element; Step S7: Comparing the stress tensor of each element with its pre-configured threshold and assigning color values ​​to the finite element mesh of each element. Compared with the prior art, this invention has the advantages of real-time performance and high accuracy.

Disclosed herein are methods of analyzing a tissue sample using quantitative phase contrast microscopy, as well as corresponding microfluidic systems and corresponding devices. The methods include providing the tissue sample in a sample volume of a microfluidic system, wherein the tissue sample includes a plurality of biological cells forming a continuous tissue material. At least a portion of the tissue sample is lysed into single cells and / or cell aggregates in a carrier fluid in the sample volume. A carrier fluid flow is generated from the sample volume to a measurement volume of the microfluidic system, and a first phase shift image of the single cells and / or cell aggregates in the measurement volume is acquired with a quantitative phase contrast microscope.

The invention discloses application of an acellular matrix material as a tissue damage or tumor targeting probe or carrier. A preparation method of the acellular matrix material comprises the following steps: pretreating fish tissues; performing decellularization treatment on the pretreated fish tissue to obtain a decellularized fish tissue material; the preparation method comprises the following steps: freeze-drying, grinding and digesting the decellularized fish tissue material, then carrying out ultrafiltration and centrifugation to intercept filtrate with the molecular weight of less than 50KDa, and freeze-drying to obtain the decellularized matrix material. The acellular matrix material disclosed by the invention has good blood compatibility and has a targeting effect on tissue injury, especially myocardial injury parts, diabetic nephropathy tissues or tumors.

A tissue dispenser features a main housing to removably receive tissue material and a sensor housing mounted via a specialized mechanism. This mechanism includes an actuating mechanism actuable in a locked and unlocked state to release the sensor housing. The sensor housing detects tissue depletion, unauthorized access, and operational status, sending relevant notifications. This ensures timely maintenance and security. The design allows for easy replacement of tissue material and the sensor housing, making it ideal for various environments. The system enhances convenience and operational efficiency, offering automated control and reducing manual intervention.

The present application relates to a dose evaluation method, an irradiation condition selection method and a treatment plan generation apparatus. The dose evaluation method comprises: acquiring tissue material information; determining a conjugate flux corresponding to a tissue material according to the tissue material information; and on the basis of an irradiation condition in combination with the conjugate flux corresponding to the tissue material, obtaining a radiation absorption dose corresponding to the tissue material under the irradiation condition. By using the method, a radiation absorption dose corresponding to a tissue material can be quickly calculated, thereby improving the efficiency of dose calculation under a plurality of irradiation conditions, and radiation absorption doses corresponding to each tissue material under different irradiation conditions can be quickly evaluated, so as to facilitate the quick selection of a suitable irradiation condition from among the plurality of irradiation conditions, thereby greatly shortening the formulation time of a treatment plan.

The present application discloses a kind of prosthesis with elastic pipeline and its manufacturing method, manufacturing method includes: according to the three-dimensional image of organ, the first tissue mold and the second tissue mold with elasticity are made;First false tissue material is coated on the surface of the first tissue mold, and the first false tissue with closed end and elasticity is made;The first false tissue is correctly positioned in the second tissue mold;Gelatinous second false tissue material is injected into the second tissue mold, and the first false tissue is covered;The interior of the first false tissue has first pressure value;Negative pressure defoaming step is applied to the second false tissue material;Freezing and thawing step is applied to the second false tissue material, to be shaped as second false tissue, in the thawing process in the freezing and thawing step, the interior of the first false tissue is repeatedly applied to decompression and pressurization step, and the decompression and pressurization step is executed below the first pressure value;The second tissue mold is removed, and the manufacturing of the prosthesis with elastic pipeline is completed.

A device for real-time monitoring of liquid absorbance and swelling characteristics of soft-tissue materials is provided herein. The device includes a microfluidics circuit configured to monitor volumetric changes in fluids pumped through the circuit, a sample chamber assembly for holding a sample of the soft-tissue material, a flow chamber assembly connected to the microfluidics circuit and the sample chamber assembly, a flow sensor positioned within the microfluidics circuit and configured to measure flow rate of fluids passing through the circuit, and a control system configured to control the microfluidics circuit and to collect data related to the volumetric changes in the fluids and the swelling characteristics of the soft-tissue material.

The invention relates to a preparation method and application of a gentamicin sulfate acellular matrix bacteriostatic slice, and the preparation method comprises the following steps: S1, taking an animal skin material, degreasing, washing and cutting to obtain a tissue material; s2, immersing the tissue material in sterile water for multiple times of ultrasonic cleaning, and then adding the tissue material into a cleaning solution for multiple times of soaking and cleaning to obtain a decellularized tissue; s3, freeze-drying the decellularized tissue, and grinding at-20 to 0 DEG C to obtain decellularized matrix powder; s4, adding the acellular matrix powder, collagen powder and gentamicin sulfate into normal saline, and uniformly mixing to obtain composite gel; and S5, pouring the composite gel into a mold, spreading the composite gel, performing pre-compression molding, and performing freeze-drying to obtain the gentamicin sulfate acellular matrix antibacterial slice. The acellular matrix treated by combining a physical means and a chemical means is cooperated with the collagen and gentamicin sulfate, so that the antibacterial sheet has the effects of high biocompatibility, long-acting and stable antibacterial effect and excellent mechanical property.

A method for constructing a personalized human eye model. This includes the following steps: (1) simplifying the structural parameters of the human eye to establish a personalized three-dimensional full-eye geometric model; (2) determining the viscoelastic material parameters of the human cornea; (3) using fluid-structure interaction to simulate the actual boundary conditions of the human eye, analyzing the changes in the actual state of the human eye, selecting appropriate element types, discretizing the model into a finite number of aggregates, completing the construction of the finite element human eye model, and solving the model using finite elements; (4) simulating optical coherence elastography of the anterior segment tissues such as the cornea. Considering the individual differences in the geometric morphology and tissue material parameters of the human eye, based on clinical ophthalmological diagnostic data, a personalized full-eye model containing complete geometric morphological information of the human eye was established in finite element software using an elastography method, providing theoretical guidance and technical support for ocular tissue optical coherence elastography equipment.

The utility model discloses a pathological tissue embedding box relates to embedding box technical field, including box body and lid unit, and the top of box body left side wall is equipped with the lock hole, and the upper right side wall of box body is equipped with the clamping hook, and the left side of lid unit is equipped with the locking unit of detachable connection with the lock hole, the right side of lid unit is equipped with the connection rotating unit, and the connection rotating unit is detachably connected with the clamping hook, and can have relative rotation, and the middle position of box body inner chamber is equipped with the short torus, and the bottom wall of box body inner chamber located short torus outside evenly is equipped with a plurality of big penetration holes, and the bottom wall of box body inner chamber located short torus inside evenly is equipped with a plurality of small penetration holes, the utility model discloses box body and lid unit separate setting, can replace the lid unit of adaptation according to the specific application scene, and through locking unit and connection rotating unit realize quick installation, and it is convenient to adapt various pathological tissue material taking, and effectively improve pathological tissue material taking, embedding and the efficiency of section.

The utility model relates to the technical field of rodent nose tissue pathological specimen material taking, specifically discloses rodent nasal mucosa tissue material taking device, the one side of fixed plate is provided with first fixed clamping groove and second fixed clamping groove respectively, is provided with head container on the fixed plate, is provided with first clamping groove insertion port, second clamping groove insertion port and cutting knife clamping groove on head container respectively, and the one side of head container is provided with scale, the rodent nasal mucosa tissue material taking device whole simple structure, and the installation and use are convenient, and the material taking work of rodent nasal mucosa tissue of staff is convenient, since setting up the scale for measuring distance on the bottom plate, a plurality of graduation grooves are opened on the scale, the position of rodent head tissue is measured through the scale, is convenient for its accurate cutting, thereby help to improve the accuracy of rodent nasal mucosa tissue material taking.

There is a need in the art for synthetic tissue models that not only simulate the tactile properties of tissues and organs but further withstand and respond in an analogous fashion to the application of energy, particularly heat and electrical energy such as accompany electrosurgery. Described herein are materials and methods useful in the construction of synthetic tissue models, particularly conductive synthetic tissue materials made from a state-sensitive, cross-linked polymer composition, that have utility in connection with thermal treatment training and simulation exercises, and moreover provide a current controlled treatment field profile analogous to that of existing tissue to that of the present invention. To that end, the simulated tissues and anatomical models of the present invention are fabricated from a hydrogel composition that undergoes partial or complete transition from its native state prior to treatment (e.g., thermal or non-thermal treatment) to one or more other states when exposed to energy, including but not limited to the following state transitions: discoloration, denaturation, coagulation, carbonization, vaporization, melting or other energy-induced state transition. These transitions facilitate the generating and detecting of a lifelike treatment field profile.

Transport device (10) for at least one, in particular contamination-free, transport of at least one object to be transported between at least two different external environments, in particular for the transport of at least one container (20), in particular of at least one container (20) filled with a pharmaceutical product and / or a biological material, for example a genetic material and / or a cell culture and / or a tissue material, wherein the transport device (10) comprises at least one housing (120), wherein the housing (120) has at least two housing parts (130), a transport interior (121), an exchange opening (150) and a gas passage (140), wherein the housing (120) is designed to be variable into several states, wherein the several states comprise at least one open state, one closed state and one partially open state.wherein in the open state the at least one object to be transported can be inserted into and / or removed from the transport interior (121) through the exchange opening (150), wherein in the closed state the transport interior (121) is sealed by housing parts (130) of the housing (120), wherein in the partially open state the transport interior (121) is separated from the respective environment by housing parts (130) of the housing (120), but is connected to the respective environment by means of the gas passage (140) in a gas-permeable, in particular gas-permeable sterile, manner.

The invention belongs to the technical field of pathogen collection, and particularly relates to a medical microorganism collection device which comprises an air pressure box, the air pressure box is hollow, a protective cover is fixedly connected to the top wall of the air pressure box, a placement box is fixedly connected to the top wall of the air pressure box, the placement box is arranged in the protective cover, and the placement box is hollow. The hollow part of the placing box communicates with the hollow part of the air pressure box, and the inner wall of the protective cover is slidably connected with a pushing plate. In the tissue placement process, the binding air bag is preliminarily expanded to pre-fix tissues, after the tissues are placed in place, the tissues in different shapes are fixed, triangular layout is formed for the tissues, the tissues are limited from multiple directions, shaking of the tissues during collection is effectively avoided, tissue fluid aggregation is promoted through regular extrusion, and the tissue fluid collection efficiency is improved. The collection success rate is increased, the tissue fluid can be conveniently collected, and pathogens in the tissue fluid can be subsequently analyzed and detected.

The present application relates to ascites drainage technical field, specifically, it relates to a kind of ascites drainage device for cirrhosis nursing, including the collection component for collecting ascites and the drainage tube component for draining ascites, and the drainage tube component is equipped with the clear block component for cleaning the tissue material blocked in the drainage tube component;Clear block component includes movable sleeve structure, extrusion structure, the pressing structure for triggering extrusion structure contraction extrusion and the press handle structure for pushing the pressing structure, which are movably sleeved on the drainage tube component;Movable sleeve structure includes barrel movable sleeve, mounting groove and pressing groove.The device is provided with clear block component, after the drainage tube is blocked by tissue material when cirrhosis patient is drained, medical staff can hold press handle structure to clear block, it is simple and convenient;After clearing block, through the cooperation of first magnetic buckle, first magnetic attraction slot and limiting bolt, the drainage tube can be further extruded and closed, reduce the infection risk caused by subsequent cleaning collection barrel.

This invention provides a method, apparatus, and electronic device for calculating multi-ion Monte Carlo doses, applicable to the fields of physics and computer science. The method includes: simulating the transport process of multiple principal particles in tissue material in a current batch to obtain the transport results of multiple principal particles; wherein the principal particles in different batches may be the same or different; constructing index information based on the principal particles and tissue material, and using the index information to sample secondary particles generated during the transport process from a preset database, wherein the preset database includes characteristic distribution information of secondary particles from multiple sources; pushing the secondary particles into a corresponding secondary particle stack and using a designated thread of the GPU to calculate the transport result of each secondary particle in the tissue material; and determining the Monte Carlo dose of the target ion based on the transport results of the principal particles and the secondary particles.

The invention discloses an acellular matrix hydrogel material as well as a preparation method and application thereof. The preparation method comprises the following steps: pretreating fish tissues; performing decellularization treatment on the pretreated fish tissue to obtain a decellularized fish tissue material; the preparation method comprises the following steps: freeze-drying, grinding and digesting the decellularized fish tissue material, and collecting and freeze-drying filtrate of which the molecular weight cut-off is not less than 100KDa through ultrafiltration and centrifugation, so as to obtain the decellularized matrix hydrogel material. The acellular matrix hydrogel material provided by the invention takes the swimming bladder as a raw material, has strong fluidity, can be used for low-resistance cardiac catheter injection, can quickly form hydrogel, has excellent oxidation resistance and good blood compatibility, can improve the local microenvironment of a myocardial ischemia focus, and can be used for treating myocardial ischemia. The repairing of myocardial injury is promoted, so that the recovery of heart tissue structure and function is realized, and a foundation is laid for developing a natural extracellular matrix injectable hydrogel material for treating myocardial infarction.

The application provides a dose determination method, device and system based on Monte Carlo beam modeling, relates to the field of physics and computers, and in particular to the application of physics and computer technology in the field of radiotherapy. The method comprises the following steps: obtaining a plurality of target data, wherein the target data is obtained based on actual measurement and is used to describe the characteristics of a particle beam transmitted by a target device; performing inverse optimization on at least part of source parameters in an original model based on the plurality of target data to obtain target parameters and a target model containing the target parameters, wherein the source parameters are input data of the original model and are used to describe the initial state of the particle beam before entering the tissue material; and determining a target dose based on the target model.

The invention relates to the field of protoplast preparation, in particular to a method for preparing and converting dactylis glomerata protoplast. The method comprises the following steps: S11, taking dactylis glomerata leaves, putting the dactylis glomerata leaves into a conical flask, and adding enzymatic hydrolysate for completely soaking; s12, the soaked dactylis glomerata is placed in a vacuum vessel to be vacuumized; s13, putting into a horizontal low-speed shaking table, and continuing enzymolysis in a dark place to obtain enzymatic hydrolysate containing protoplast; s14, flushing the tissue material fragments with a W5 solution for one to two times, reserving filtrate, and performing low-speed centrifugation to obtain turbid precipitates; s15, discarding the supernatant, washing with a W5 solution, and resuspending the protoplast; and S16, carrying out low-speed centrifugation, removing supernatant, and adding an MMG solution as required for resuspension. The enzymatic hydrolysate is adopted, the dactylis glomerata leaf is used as a material, the dactylis glomerata protoplast can be efficiently prepared, the yield, activity and transformation efficiency of the obtained protoplast are high, and the method has important basis and significance for subsequent dactylis glomerata gene function research and genetic character improvement research.

Provided are storage methods and storage systems for cells prepared using somatic cell nuclear transfer (NT) technology, the cells having homozygous genotypes for genes of human leukocyte antigen (HLA)-A, HLA-B, HLA-DR, etc. Storage of NT cell-derived stem cells can be applicable to autologous or allogeneic patients, and can provide transplantable cells and tissue materials for treatment of various diseases, such as diabetes, osteoarthritis, Parkinson's disease, etc.

The utility model provides a kind of self-cleaning pathological tissue material taking platform, including equipment component, equipment component is provided with water scraping subassembly, auxiliary assembly is provided on water scraping subassembly, linkage assembly is provided below auxiliary assembly, equipment component includes base, the upper end of base is fixedly connected with operation table plate, the left and right two inner walls of operation table plate are symmetrically fixedly connected with multiple water outlets, the upper end right side of operation table plate is provided with water basin groove, water scraping subassembly includes strip groove being opened in the right inner wall of operation table plate, operation table plate is stably supported by the base in equipment component, left and right symmetrical water outlet and water basin groove form efficient cleaning system, can promptly discharge the waste liquid generated in the process of material taking, guarantee that operation table is dry and clean, maintain good working environment, and water scraping subassembly electric push rod drives water scraping strip plate to move, spring connection's triangular scraper is closely attached operation table plate, can quickly remove table area water, tissue debris and other sundries, significantly improve cleaning efficiency, reduce manual cleaning workload.

The invention discloses a mild and efficient makeup removal wet tissue and a preparation method thereof, and belongs to the technical field of cosmetics. The cleansing oil is used for solving the technical problems that in the prior art, a conventional surfactant adopted by the cleansing oil is poor in oil phase component emulsifying capacity, and an adopted wet tissue material is poor in cleansing emulsion loading capacity. The preparation method of the mild and efficient makeup removal wet tissue comprises the following steps: S1, uniformly mixing an oil phase system, a water phase system, a composite surfactant and a high polymer carrier to obtain makeup removal emulsion; s2, the spinning base cloth is soaked in the makeup removing emulsion, and the mild and efficient makeup removing wet tissue is prepared. Glucose is modified by glycine and then reacts with methyl cocoate to synthesize the composite surfactant. Glucan and palmitoleic acid are subjected to an esterification reaction, and a high polymer carrier is prepared. The prepared mild and efficient makeup removal wet tissue has the advantages that the emulsification efficiency of a water phase component and an oil phase component is high, and the load rate of the wet tissue material to makeup removal emulsion is high.

Soft tissue supports, soft tissue implants, and methods of making and using soft tissue supports are disclosed. One soft tissue support includes a unitary piece of processed porous tissue material having an anterior portion and a posterior portion. The anterior and posterior portions define a cavity therebetween. The cavity is sized to receive a breast implant therein. The cavity has at least one opening sized to receive the breast implant therethrough. One soft tissue implant includes the soft tissue support and a breast implant positioned within the cavity of the soft tissue support. The implant may further include a soft tissue graft configured to support the processed porous tissue material and the breast implant. A method of using a soft tissue support includes inserting a breast implant into the soft tissue support, and implanting the soft tissue support containing the breast implant in the cavity.