219 results about "Tissue material" patented technology

The present invention comprises a percutaneously implantable replacement heart valve device and a method of making same. The replacement heart valve device comprises a stent member made of stainless steel or self-expanding nitinol, a biological tissue artificial valve means disposed within the inner space of the stent member. An implantation and delivery system having a central part which consists of a flexible hollow tube catheter that allows a metallic wire guide to be advanced inside it. The endovascular stented-valve is created from a glutaraldehyde fixed biocompatible tissue material which has two or three cusps that open distally to permit unidirectional blood flow. The present invention also comprises a novel method of making a replacement heart valve by taking a fragment of biocompatible tissue material and treating, drying, folding and rehydrating it in such a way that forms a two- or three-leaflet / cusp valve with the leaflets / cusps formed by folding, thereby eliminating the extent of suturing required, providing improved durability and function.

A soft tissue fixation system, most typically applicable to orthopedic joint repairs, such as anterior cruciate ligament (ACL) knee repair procedures, comprises an implant which is placeable in a tunnel disposed in a portion of bone, wherein the tunnel is defined by walls comprised of bone. A first member is deployable outwardly to engage the tunnel walls for anchoring the implant in place in the tunnel, and a second member is deployable outwardly to engage tissue material to be fixed within the tunnel. The second member also functions to move the tissue material outwardly into contact with the tunnel walls to promote tendon-bone fixation. Extra graft length is eliminated by compression of the tendon against the bone at the aperture of the femoral tunnel, which more closely replicates the native ACL and increases graft stiffness. The inventive device provides high fixation of tendon to bone and active tendon-bone compression. Graft strength has been found to be greater than 1,000 N (Newtons), which is desirable for ACL reconstruction systems.

A biomaterial useful for bioprostheses such as bioprosthetic heart valves is provided in which the fixed tissue has improved elastic properties. The high elastin-containing biomaterial is further characterized by having anisotropic properties wherein the biological material has a greater stiffness in one direction and a greater elasticity in a cross direction. For instance, the biological material has an elastin content of about 30% by weight. In one embodiment, the biological material is vena cava tissue.

A biomaterial useful for bioprostheses such as bioprosthetic heart valves is provided in which the fixed tissue has improved elastic properties. The high elastin-containing biomaterial is further characterized by having anisotropic properties wherein the biological material has a greater stiffness in one direction and a greater elasticity in a cross direction. For instance, the biological material has an elastin content of about 30% by weight. In one embodiment, the biological material is vena cava tissue.

An ablation and monitoring system comprises a catheter, an optical coherence tomography (OCT) system, and an ablation generator. The catheter comprises one or more optical fibers to transmit a light beam to a tissue material and collect a reflected light from the tissue material. The OCT system is in optical communication with the catheter via the one or more optical fibers, providing the light beam to the one or more optical fibers and receiving the reflected light from the one or more optical fibers. The ablation generator is in electrical communication with the OCT system and with the catheter. The ablation generator provides radio frequency energy to the catheter for ablating the tissue material, monitors and assesses the ablation based on an information signal received from the OCT system.

A method of cutting tissue material of biology origin employs a plotted water-jet or RF cutting system. The cutting system is computer controlled and includes a water-jet or RF cutting means combined with a motion system. The cutting energy is selected so that communication of thermal energy into the segment beyond the edge is minimized to avoid damaging the segment adjacent the edge.

The invention relates to shielded reciprocating surgical file system for precisely removing bone and / or other tissue material. The system allows a user to maneuver the system and navigate into hard to access sites under a direct vision mechanism included in the system. A transmission mechanism converts rotary motion from a motor into reciprocating motion and provides it to the surgical file for precision bone and / or tissue removal. A pulsatile pump mechanism is operatively coupled with the transmission mechanism and provides irrigating fluid to the surgical site.

The invention relates to shielded reciprocating surgical file system for precisely removing bone and / or other tissue material. The system allows a user to maneuver the system and navigate into hard to access sites under a direct vision mechanism included in the system. A transmission mechanism converts rotary motion from a motor into reciprocating motion and provides it to the surgical file for precision bone and / or tissue removal. A pulsatile pump mechanism is operatively coupled with the transmission mechanism and provides irrigating fluid to the surgical site.

A flexible auger design for low-torque transmitting drive shafts, which allows effective tissue material transport through curved, flexible tubes and channels. A hollow auger has a hollow center, so that the helical member hugs the inner wall of the tube and material is transported along the center axis and the inner wall of the tube. The hollow flexible auger allows for transportation of material from an operative location in the patient (material removal) as well as to operative location in the patient (material delivery).

The invention discloses a printing device for a three-dimensional biological structure. The printing device comprises an execution unit with a liquid supply system, and a control unit, wherein the liquid supply system comprises an air compressor, an air capacitor communicated with an air outlet of the air compressor, and a liquid storage tank; a liquid outlet of the liquid storage tank is communicated with a liquid inlet of a spray head; a liquid inlet of the liquid storage tank is communicated with an air outlet of the air capacitor; a pressure reducing valve is arranged on a pipeline between the liquid storage tank and the air capacitor; the opening degree of the pressure reducing valve can be adjusted, and thus liquid drops at a spray nozzle of the spray head are enabled to not drop off; the height of the liquid storage tank can be adjusted, and thus the lowest end of a liquid level at the spray nozzle of the spray head is leveled with the spray nozzle of the spray head. The printing device disclosed by the invention can be widely applied to forming of biological scaffolds with various shapes, can be used for printing vascular structures and has the advantages of high printing precision, simpleness in operation, low cost and the like. Due to the adoption of the design of a replaceable clamp, a replaceable working face and a replaceable Z-shaped mounting plate, the printing device can be used for printing biological structures with different sizes and different tissue materials.

The present invention relates generally to a tissue preparation including tissue cells and extracts thereof useful for promoting or facilitating the growth, development and differentiation of cells and tissues. More particularly, the present invention provides muscle-derived material comprising intact or extracted extracellular matrix and / or cells as well as cytokines, growth factors and other components. The muscle preparations of the present invention resemble basement membrane and are derived from cellular-based material. The muscle preparation may be used in vitro or in vivo as inter alia, a cellular scaffold in various tissue engineering applications and in other cell culture systems for nurturing and enriching a range of cell types including, but not limited to, precursor and stem cells such as pre-adipogenic cells. The muscle preparation is also useful as a base for creams, such as in the cosmetic and topical therapeutic industries and as a matrix or additive in the food industry.

A soft tissue fixation system, most typically applicable to orthopedic joint repairs, such as anterior cruciate ligament (ACL) knee repair procedures, comprises an implant which is placeable in a tunnel disposed in a portion of bone, wherein the tunnel is defined by walls comprised of bone. A first member is deployable outwardly to engage the tunnel walls for anchoring the implant in place in the tunnel, and a second member is deployable outwardly to engage tissue material to be fixed within the tunnel. The second member also functions to move the tissue material outwardly into contact with the tunnel walls to promote tendon-bone fixation. Extra graft length is eliminated by compression of the tendon against the bone at the aperture of the femoral tunnel, which more closely replicates the native ACL and increases graft stiffness. The inventive device provides high fixation of tendon to bone and active tendon-bone compression. Graft strength has been found to be greater than 1,000 N (Newtons), which is desirable for ACL reconstruction systems.

A method of making a replacement heart valve device whereby a fragment of biocompatible tissue material is treated and soaked in one or more alcohol solutions and a solution of gluteraldehyde. The dried biocompatible tissue material is folded and rehydrated in such a way that forms a two- or three-leaflet / cusp valve without affixing of separate cusps or leaflets or cutting slits into the biocompatible tissue material to form the cusps or leaflets. After the biocompatible tissue material is folded, it is affixed at one or more points on the outer surface to the inner cavity or a stent.

The present invention discloses a method of calcification-resisting modifying for the heterologous biology tissue material, in the method the tannic acid solution is used to immerse the tissue; the concentration of the tannic acid is between 1 and 6%, the pH value of the solution is between 4.0 and 6.0, the immersing temperature is between 18 and 32 DEG C, and the immersing time is between 24 and 96 hour. The method of the invention can simultaneously crosslink the collagen fiber, the elastic fiber and glycosaminoglycan in the cell epimatrix of the tissue material, reduce the degradation when the tissue is implanted to the body, compensate the insufficiency that the pentanedial only crosslinks the collagen fiber and remarkably increase the calcification-resisting capability of the material; has the effect of antibacterial and reducing the protein antigenicity, and helps to increase the calcification-resisting capability and bioavailability of the material. The intercrossed tissue material has the advantages of good biostability, reinforced biomechanical property and long service lifetime.

The invention discloses a wheel axle fatigue test device and method. The wheel axle fatigue test device includes: a scaled wheel and a track wheel, respectively simulating the actual wheel and the actual track; Scaled and scaled, the track wheel is made of materials with the same composition, microstructure and mechanical properties as the actual track; the rotary drive mechanism drives one of the scale wheel and the track wheel; the vertical loading system applies force to the driven wheel The vertical load makes the tread of the scaled wheel contact the track wheel; the damping and braking mechanism applies torque to the driven wheel to simulate the friction and braking force between the actual running of the wheel and the actual track; the controller controls the rotation drive mechanism, vertical Loading mechanism and damping and braking mechanism.

The invention relates to a tissue dewaxing transparent agent free of benzene, which is used in biological histology, histopathology or forensic science, can make a tissue transparent, and can make the tissue dewaxed. The tissue dewaxing transparent agent belongs to the technical field of in vitro diagnostic reagents. The tissue dewaxing transparent agent mainly contains 95%-100% of alicyclic hydrocarbon, and the balance of accessories; the alicyclic hydrocarbon is a monocyclic alicyclic hydrocarbon or a bicyclic alicyclic hydrocarbon. The tissue dewaxing transparent agent free of benzene has the advantages of being non-toxic, soft in effect, and not easy to cause shrinkage, deformation, hardening and embrittlement of a tissue material, capable of improving the section intact rate, insensitive to the humid environment, not easy to muddy due to absorption of moisture in the air, and the like; not only can be used for liquid based cytology, immunohistochemistry, biological histology, routine pathological diagnosis, and immunohistochemical diagnostic techniques, is also suitable for special staining method and histochemical techniques. The refractive index of used alicyclic hydrocarbon transparent agent (cyclohexane) is 1.42, the (methyl cyclohexane) refractive rate is 1.42, and is basically consistent with the tissue refractive index (1.418), and the transparent effect is better.

There are provided a cured porous calcium phosphate material, an alternative living body tissue material, a tissue engineering scaffold and a drug support medium for DDS using the same. The cured material includes penetration pores with a diameter of 70 μm or more, preferably 100 μm or more, disposed in a three-dimensional network structure, and having enough porosity for the penetration of blood vessels and tissues. Drugs important for promoting bone formation and preventing infection can be added thereto, whereby the drugs are controllably released.

The invention provides a finite element modeling method for a human head for researching collision damage of an automobile. The finite element modeling method comprises the following steps: firstly, carrying out tomography and nuclear magnetic resonance scanning on the human head to obtain a tomography scanning image; secondly, importing the tomography scanning image into Mimics, and preprocessing the tomography scanning image to obtain point cloud data; thirdly, importing the point cloud data obtained in the second step into Geomagic Studio, and carrying out parameterized processing on the point cloud data to generate curved surfaces; detecting the generated curved surfaces, and fitting all the curved surfaces by using cubic Bezeir curves to obtain a three-dimensional geometrical model; fourthly, importing the three-dimensional geometrical model into HyperMesh for dividing meshes, setting the type of a unit body into a linear tetrahedral unit and optimizing local grids to obtain a three-dimensional solid model; fifthly, importing the three-dimensional solid model into Abaqus, defining characteristic parameters of tissue materials, and adding boundary and contact conditions for tissues to obtain a finite element model of the human head.

The invention provides a separating method and an application of fat stem cells. The method provided by the invention comprises steps that: (1) an obtained fat cell tissue material containing fat stem cells is washed by using a washing liquid; (2) the material is digested by using collagenase, such that a digested tissue mixture is obtained; (3) the tissue mixture is filtered, such that a filtrate containing the fat stem cells is obtained; and (4) the filtrate is centrifuged, and an obtained precipitate is a fat stem cell mass. With the method provided by the invention, fat stem cells can be effectively separated; the purity of the obtained fat stem cells is high; and the proliferation speed of the fat stem cells is high. The fat stem cells separated by using the method provided by the invention can be applied in regeneration medicine, anti-aging treatments, and the like.

The invention relates to a full-degradable skin-care high-softness fine-denier cellulose spunlace wet tissue material which is relatively soft, fine and skincare in a wet-state using process, cannot relatively slide and can be fully biodegraded, and a production method for wet tissue. The wet tissue material is prepared by mixing the following raw materials by weight percent: 10-80% of 5-15 mm cellulose fibers with the fineness of not more than 0.9 dtex and 90-20% of wood pulp subjected to defibrination and fibrillation. The wet tissue material has the advantages that firstly, the cellulose fibers with the fineness of not more than 0.9 dtex is deeply dispersed by adopting a high-pressure defibering technology, so that a surface layer of the spunlace wet tissue is relatively fine and soft, and a precedent that the cellulose fibers can be separately combined with other materials-spunlace within one minute is set; secondly, the raw materials can be fully degraded without residues and are environment-friendly; thirdly, wood pulp fibers serve as a framework of the spunlace wet tissue, so that the strength of the cellulose fiber material can be enhanced while the cost is reduced; fourthly, the loss rate of the fibers during production is reduced to be 1-3% from 6-8%, so that the utilization rate of the raw materials is greatly increased.

The invention discloses a wet tissue material capable of being broken through flushing and a production method thereof. The wet tissue material is produced from viscose rayon, wood pulp cellulose and ES fiber as raw materials and through steps of a wet-process netting process, a hot-air treating process and a hot rolling process. The wet tissue material is prepared with a papermaking technology as a base and is prepared through non-weaving technologies, such as the wet-process netting process and the like. The wet tissue material, besides characteristics of common wet tissue, also is quick to produce, is large in yield, is constant in quantitation of fiber nets, is light and thin, is degradable and is capable of being broken through flushing.

The invention discloses a 3D hepatoma tissue construction method based on biological 3D printing hydrogel. The method comprises the steps as follows: 1) a GelMA biomaterial is synthesized, and the acylation rate and light polymerization time of the GelMA biomaterial are detected; 2) after GelMA and an photoinitiator are uniformly mixed and dissolved, human hepatoma cell HepG2 and GelMA solutions are uniformly mixed, the cell concentration is adjusted to 1*10<6> / mL, and biological printing ink is prepared. Biological printed cells and a hydrogel system are placed under an ultraviolet lamp for light polymerization for 5 min to be cured, the cured system is placed in a 10%FBS culture solution to be cultured for 7 d, and a hepatoma tissue engineered unit containing an HepG2 source is prepared and saved for later use; 3) the swelling ratio and balance water content of a 3D hepatoma tissue material are detected; 4) the growth states of 2D and 3D on the seventh day are detected with a BE histochemistry method. The method is reliable, convenient to operate and high in repeatability and can effectively promote formation of hepatoma tissue functions and provide beneficial reference for scientific research of hepatic tissue engineering and clinical treatment of hepatoma.

The invention discloses a self-sucking biological 3D printing nozzle device and a control method thereof, and belongs to the field of tissue engineering and biological 3D printing. The nozzle device is characterized by comprising a nozzle, a plunger cylinder, screws, an inclined disc cover, a motor base, a motor, a coupling, a transmission shaft, a flat key and a flow distribution cylinder. The motor drives the transmission shaft to rotate through the coupling to drive the plunger cylinder coaxially mounted in the flow distribution cylinder to rotate, so that a plunger body on the plunger cylinder moves up and down in a cylinder plunger hole under the combined effect of spring force and an inner inclined surface of the inclined disc cover to realize continuous sucking and pressing actions to finish continuous biological material printing work. The nozzle device effectively prevents the trouble of the need of stopping to replace the nozzle device when being applied to continuous printing of large-size tissue material organs. The nozzle device has the advantages of simple and skillful structure concept, easy realization of automatic control, improvement of the printing efficiency and effective solving of the continuous supply printing problem.

A device and method for removing irregular tissue bodies from the skin comprising a tubular member with an internal blade edge positioned adjacent to either or both of its ends. One or both ends have continuously curved cross-section defining an internal blade edge. The edge is moved in a reciprocating fashion. An elongated plunge member larger than the tubular member permits a user to remove the cut and stored irregular tissue material. The central through opening is optionally filled with a suitable substance to enhance or complement the cutting action of the blade.

The invention relates to a multi-parameter controlled water cooling system. It has three control units to adjust the temperature, pressure and flow of cooling water respectively. The water temperature signal detected by the temperature detection switch is transmitted to the PLC programmable controller. The temperature of the cooling water; the signal detected by the pressure detector is transmitted to the PLC programmable controller, and the PLC programmable controller controls the speed of the pump by adjusting the frequency conversion motor frequency to adjust the cooling water pressure; the electromagnetic flowmeter detects the flow of each cooling pipeline and The signal is transmitted to the PLC programmable controller, and the PLC programmable controller adjusts the flow of each cooling pipeline by controlling each regulating valve. It improves the adjustment range and accuracy of the temperature, pressure and flow of cooling water, and the three parameters can be adjusted independently, with little correlation; it improves the material performance, ensures the fine structure of the material, and improves the cleanliness and uniformity of the material .

The present invention discloses a super-thick tissue slice preparation method, which comprises: obtaining a tissue material to be observed; preparing tissue material slices with a thickness of 1-8 mm,and carrying out transparentizing on the tissue material slices; and carrying out fluorescent staining on the transparent tissue material slices. The method for reproducing the three-dimensional tissue structure of a tissue slice comprises: preparing a transparent tissue slice with a thickness of 1-8 mm; obtaining the image data of the transparent tissue slice by using a fluorescence microscope;recombining the image data to form three-dimensional model data; and based on the three-dimensional model data, outputting a three-dimensional image. According to the present invention, with the super-thick tissue slice preparation method and the three-dimensional tissue structure reproducing method, the tissue slice is subjected to grease removing to achieve the transparent state so as to increase the penetrating depth of laser in liver tissue and reduce the light scattering, such that the deep imaging of the tissue can be achieved, the real cell structure of the tissue can be reflected, andthe imaging efficiency and the fidelity can be improved.