10 results about "Biological structure" patented technology

This invention provides a cross-modal translation method, comprising acquiring scRNA-seq data and / or scDNAm data and preprocessing them; performing feature mapping to obtain dimension-aligned low-dimensional potential representations of RNA attributes and / or DNAm attributes; performing cross-modal transformation processing that preserves biological features to obtain low-dimensional features of DNAm attributes and / or RNA attributes; and performing high-dimensional reconstruction processing to obtain scDNAm prediction data and / or scRNA-seq prediction data. The advantages of this invention are that it enables bidirectional cross-modal translation of scRNA-seq and scDNAm, expanding the application scenarios of multi-omics analysis; the cross-modal transformation preserves biological features throughout, ensuring that the generated prediction data closely matches the biological structure of the real data, rather than simply being a numerical fit; and it forms a complete processing link from raw data to prediction data, with the output high-fidelity prediction data directly usable for downstream multi-omics joint analysis and mechanism mining.

The application belongs to the technical field of antibacterial medicine, and particularly relates to a polypyridine ruthenium complex with a double-amide biological structure modification and a preparation method and application thereof. The application provides a double-amide structure ruthenium (II) complex, the complex has excellent antibacterial activity on staphylococcus aureus and MRSA, has a unique action mechanism, is not easy to induce drug resistance, has high in-vivo safety, and can be used for treating drug-resistant bacterial infection.

This invention is an advanced bioimaging device allowing for the observation and analysis of living cells and intracellular reactions in real-time without the need for staining. It uses a combination of nanophotonic microscopy, nanobiological sensors, artificial intelligence processing, and ultra-sensitive spectroscopy technology to record and analyze intracellular changes without destroying the biological structure. The key feature of this technology is non-invasive and live imaging of cells and tissues without the need to add dyes or external chemicals that can affect the normal behavior of the cell. It offers higher resolution, no chemical interference, and the ability to automatically analyze data compared to traditional imaging methods such as fluorescence and phase contrast. It also includes cell research, drug development, personalized medicine, biotechnology, nanotechnology, and medical diagnostics. This invention is designed to study molecular, cellular, and biological processes in living cells and can simultaneously perform imaging and data analysis.

The present disclosure relates to a trapezoidal column (3) for use in a medical clamping device for clamping at least one biological structure in a surgical treatment of a patient. The trapezoidal column (3) extends in a longitudinal direction (1) and is collapsible at least in said longitudinal direction (1) when applied to the biological structure together with the medical clamping device. The trapezoidal column (3) comprises at least two openings (33), each adapted to receive at least one annular filament for clamping the biological structure relative to the trapezoidal column. The openings (33) are arranged one after the other in the longitudinal direction (1) of the trapezoidal column (3) and are spaced apart from each other by a first distance by a crosspiece (9) extending in a transverse direction between a first lateral longitudinal beam (10a) and a second lateral longitudinal beam (10b). The first lateral longitudinal beam (10a) and said second lateral longitudinal beam (10b) extend in the longitudinal direction and bound the at least two openings (33) in a lateral direction.

The application provides a full-degradable flexible pressure sensor based on a luffa sponge biological structure and a preparation method.The sensor comprises, from bottom to top, a lower degradable flexible packaging layer, a lower conductive electrode, a luffa sponge structure composite conductive layer, an upper conductive electrode and an upper degradable flexible packaging layer.The application combines the natural luffa sponge flexible three-dimensional skeleton with the degradable conductive material, fully utilizes the multi-stage deformation between different conductive networks, single conductive fiber and the conductive material itself in the luffa sponge structure composite conductive layer, realizes the switching of the force sensing mechanism in different pressure ranges, expands the pressure detection range and keeps good linear response in a wide range.The device structure provided by the application utilizes the topography structure of the natural plant, is simple to manufacture and low in cost, is fully degradable under natural conditions, is environment-friendly, and can have good response to external static and dynamic pressure in a wide range.

Examples of the present disclosure relate to an apparatus comprising input circuitry configured to acquire imaging data corresponding to a branched biological structure. The apparatus further comprises image processing circuitry configured to: extract, from the imaging data, a configuration of the branched biological structure; determine graph data indicative of the configuration of the branched biological structure; and detect, based on the graph data, a biological characteristic of the branched biological structure.

This invention discloses a biomimetic mechanical tail device for a robotic fish with variable cross-section features, including a tail peduncle mechanism and a tail fin mechanism connected to the fish body. This invention draws inspiration from the biological structure and propulsion mechanism of fish tails in nature. The tail fin mechanism is crescent-shaped and includes a push rod, an upper tail fin, and a lower tail fin. The left end of the push rod passes through the tail peduncle and is threadedly connected to a spring seat. The left end of the tail peduncle is connected to the tail fin mechanism. The spring is sleeved on the outside of the spring seat and placed between the tail peduncle and the spring. A hydraulic cylinder is installed inside the distal end of the tail peduncle. The piston is fixedly connected to the left side of the spring seat through a hydraulic oil line. An elongated hole is opened in the middle of the push rod. The upper and lower tail fins are symmetrically arranged on both sides of the push rod. The middle parts of the upper and lower tail fins are slidably and rotatably connected to the elongated hole through a rotating shaft. The upper and lower tail fins are rotatably connected to the push rod through connecting rod one and connecting rod two, respectively. The left side of the upper and lower tail fins overlaps the left side of the push rod.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. Methods of biological tissue modification are also provided. The systems and methods disclosed here are uniquely different in that they aim to target, plan and treat target tissue, and selectively destroy and modify cellular architecture, but with specific intent and treatment parameters specialized for retaining specific target physical biological structures within the cell itself.

Cyclic testing machine (100) for a specimen (11) of biological structures under cell culture conditions, the machine (100) comprising: - a base (1), - a crosspiece (2) hinged at one of its first end (2') by means of a cylindrical hinge (6), in turn integral with a first end (1') of the base (1), so as to operate a cyclic rotation motion around the cylindrical hinge (6), - a weight-holding basket (8) removably fixed on the crosspiece (2), - an anchoring cylinder (14) fixed to a second end (2') of the crosspiece (2), - a stepper motor (10) supported by a support (3), in turn integral with a second end (1'') of the base (1), - a pulley (15) keyed to one end of the stepper motor (10), said machine (100) being characterised in that - an inextensible cable (17) fixed to the anchoring cylinder (14) is wound in a groove (18) of the pulley (15), which rotates by defined angles by means of the stepper motor (10) and allows the movement of the crosspiece (2) itself by means of the hinge (6); - a pressing plate (12) integral with the crosspiece (2) configured to apply a compressive load to the specimen (11).