99 results about "Biological structure" patented technology

Systems and methods for automatically populating a post-operative report of a surgical procedure are disclosed. A system may include at least one processor configured to implement a method including receiving an identifier of a patient, an identifier of a healthcare provider, and surgical footage of a surgical procedure performed on the patient. The method may include analyzing frames of the surgical footage to identify phases of the surgical procedure based on interactions between medical instruments and biological structures and, based on the interactions, associate a name with each phase. The method may include determining a beginning of each phase and associating a time marker with the beginning of each phase. The method may include populating a post-operative report with the patient identifier, the names of the phases, and time markers associated with the phases in a manner that enables the health care provider to alter the post-operative report.

The invention discloses a bamboo-like structure annularly-reinforced bamboo composite pipe and a preparation method thereof.The bamboo composite pipe sequentially comprises a lining layer, a reinforcing layer, an annular reinforcing layer and an outer protective layer from inside to outside, the thickness of the inner reinforcing layer, the thickness of the middle reinforcing layer and the thickness of the outer reinforcing layer are sequentially reduced, and radial impact resistance of the bamboo composite pipe is reinforced; according to the bamboo composite pipeline, the natural structure of'sparse inside and dense outside 'and'bending without bending' of the bamboo vascular bundle is reproduced, the circumferential stress of the pipeline can be effectively and gradually transmitted to the outer layer from the inner layer of the pipeline wall in the circumferential bearing process, local cracking caused by stress concentration is avoided, and the circumferential impact resistance and bending resistance of the bamboo composite pipeline can be remarkably improved. The circumferential reinforcing layer imitates the natural structure of bamboo wood, the biological structure characteristic that bamboo joints are periodically distributed in the length direction of bamboo stalks is reproduced, the radial ring stiffness and the deformation resistance of the bamboo composite pipe can be remarkably improved, and the defect that the transverse strength of the bamboo composite pipe is insufficient is overcome.

A patch to be placed over an injury or defect in tissue in a biological structure having a lumen and preventing migration of contents of the biological structure through the injury or the defect. The patch includes an adhesive layer configured to adhere to the biological tissue via formation of hydrogen or covalent bonds with chemical groups present in the biological tissue and a backing layer coupled to and coextensive with the adhesive layer, the backing layer configured to be impervious to the contents.

The invention provides a process for preparing a three-dimensional graphene foam metal composite material by a biological template method. The preparation method comprises the following steps: preparing through an innovative biological template method process, carrying out carbonization-activation treatment on a natural hierarchical porous biological structure serving as a sacrificial template to form a three-dimensional graphene foam skeleton with bionic hierarchical pore channels, and carrying out in-situ compounding of copper / silver metal nanoparticles through a pulse electrodeposition technology to obtain the composite material. And finally, the three-dimensional graphene foam metal composite material with ultrahigh thermal conductivity and eco-friendly characteristics is constructed. The core breakthrough of the heat-conducting property is as follows: a bionic heat transfer framework is optimized, graded pores derived from a biological template form a phonon efficient transfer path, and the axial heat conductivity is improved by more than 40% compared with that of a material prepared by a traditional chemical foaming method; according to graphene-metal interface cooperation, metal nanoparticles directionally grow on the edge of a graphene sheet layer and hole wall defect sites, and interface thermal resistance is reduced to 8.7 * 10 <-9 > m < 2 > K / W by forming a coherent interface; cross-scale heat flow guide control is achieved, specifically, phonon conduction with the in-plane heat conductivity being 1600 W / (m.K) is achieved through a high-crystallinity graphene domain in a micropore, and an electron conduction heat diffusion network is constructed through a metal filling layer in a macropore channel.

The invention relates to an early strength concrete material for an expansion joint anchoring area and a preparation method thereof, and relates to the technical field of building materials, the early strength concrete material for the expansion joint anchoring area comprises the following components in parts by mass: gel master batch, coarse aggregate, fine aggregate, silica fume, mineral powder and a polycarboxylic acid water reducer; the gelling master batch is prepared from the following components in parts by mass: tricalcium silicate, anhydrous calcium sulphoaluminate, polyvinyl alcohol, polypropylene fiber and water; the preparation method comprises the steps of gelling master batch preparation, shearing and flaking, and mixing and forming. According to the early-strength concrete material for the expansion joint anchoring area and the preparation method of the early-strength concrete material, the concrete in the anchoring area is modified by using an organic matter as a crystal nucleus, so that a compact and ordered organic-inorganic cross-linked structure with a biomimetic structure is formed, and the early-strength performance and tensile toughness of the concrete are remarkably improved.

An active and passive coupling bionic stubble cutting device based on jaw curves of African beetles relates to the technical field of agricultural machinery, and comprises a power transmission and frame component playing a role in integral supporting and transmission, a plurality of active stubble cutting components and a plurality of passive stubble fixing components are mounted on the power transmission and frame component, and the active stubble cutting components and the passive stubble fixing components are mounted on the power transmission and frame component. The passive stubble fixing component is rotatably mounted at the front end of the power transmission and rack component and passively and positively rotates along the advancing direction of a machine tool, and the active stubble cutting component is mounted at the rear end of the power transmission and rack component and is driven by the power transmission and rack component to reversely rotate; and a composite working area is formed between the active stubble cutting component and the passive stubble fixing component. According to the bionic stubble cutting device, by integrating the advantages of a biological structure, the purposes of greatly improving the stubble cutting operation quality, reducing power consumption and providing technical support for popularization and application of a follow-up sowing operation agricultural technology are achieved.

The invention relates to the technical field of image data processing, in particular to an image segmentation method and system applied to marine plankton. The method comprises the following steps: acquiring an in-situ microscopic image of marine plankton, carrying out binarization processing and connected domain analysis on the in-situ microscopic image, and screening out a biological adhesion block mass to be processed; synchronously extracting the edge contour of the biological adhesion block mass to be processed, and calculating a biological structure integrity score; selecting the candidate segmentation path with the highest biological structure integrity score as an optimal segmentation line; curvature smooth completion is carried out along the optimal segmentation line, and a single biological image is obtained; and inputting the single biological image into a pre-trained classifier to obtain a biological abundance data set. According to the method, high-precision automatic identification and abundance statistics of plankton in a complex marine environment are realized by screening and positioning the adhesion block mass, carrying out adaptive adhesion segmentation and combining multi-dimensional morphological feature classification.

The invention discloses a biological organ structure in-vitro preparation instrument, which is a precise device for preparing a biological organ structure model for in-vitro culture, relates to the technical field of biomedical experiment research, and comprises a slicing part, a micro-motion part and a linkage part, the micro semi-automatic device creatively combines the biological structure characteristics of a microelectronic control system, peripheral nervous nerves, central nervous nerves, various solid visceral organs and tumor tissues, and adopts a spiral micrometer micrometer order stepping device as an organ-like tissue thickness control structure. And the organoid tissue structure with the thickness of 100-500 microns can be intuitively, conveniently and efficiently prepared under the in-vitro sterile condition.

There is provided a bioimaging system for determining a spatial distribution of one or more physical properties within a biological structure, the system comprising: a data input configured to receive a plurality of measurements related to one or more physical fields; and a processing device configured to determine a spatial distribution of one or more physical properties within the biological structure using the plurality of measurements. The processing device forms a discretized full order model of the biological structure, describes a baseline spatial distribution of the biological structure using the model, and determines optimized values of coefficients describing the baseline spatial distribution based on the plurality of measurements. The processing device also forms a hybrid model comprising baseline spatial distribution coefficients and a set of deviation full-order model coefficients describing deviations relative to the baseline spatial distribution, determines optimized values for the baseline spatial distribution coefficients and the deviation full-order model coefficients of the hybrid model, and determining a spatial distribution of one or more physical properties within the biological structure using the optimized values of the coefficients.

The present disclosure provides a method for bioprinting a 3D structure comprising one or more bio-related materials on a superhydrophobic surface. In one embodiment, the method includes providing a composition having one or more bio-related materials dispersed in a biocompatible medium. A pattern comprising a hydrophilic material is deposited on a defined region of the superhydrophobic surface, the pattern being modeled after a biological structure. A composition having one or more bio-related materials is then bioprinted onto the hydrophilic surface to form a 3D structure, the hydrophilic surface maintaining the 3D structure in a desired position or shape on the superhydrophobic surface.

Methods and systems for characterizing a biological structure including: obtaining image data for the biological structure using an imaging system; constructing a volumetric dataset of the biological structure based on the image data; determining at least one of a plurality of sections along a plane or curve within the volumetric dataset; and characterizing, using a trained algorithm and based on at least one of the plurality of sections, the biological structure for potential tissue type or disease state.

This invention discloses a microscale biomimetic toughening additive manufacturing method for shell-like features. To address the current difficulty in achieving a balance between strength and toughness in laser additive manufacturing of metal components for the aerospace field, this invention draws inspiration from the "brick-and-mortar" biological structure of the nacreous layer of a shell. It employs a method of continuous laser layer-by-layer melting and forming / ultrafast laser interlayer micro-region precise toughening to design and construct a biomimetic toughening material with spatial overlap of "soft" and "hard" regions, thereby achieving a synergistic improvement in the strength and toughness of laser additive manufacturing of metal components.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. Methods of biological tissue modification are also provided. The systems and methods disclosed here are uniquely different in that they aim to target, plan and treat target tissue, and selectively destroy and modify cellular architecture, but with specific intent and treatment parameters specialized for retaining specific target physical biological structures within the cell itself.

A major obstacle in the field of biotherapeutics is the need for platform technologies that enable high bioavailability and long-term therapeutic exposure of biotherapies in localized disease. Traditional approaches result in problematic trade-offs, such as toxicity and off-target side effects. The present disclosure provides compounds comprising follistatin domain 1 (FSD1) of follistatin (FST), which can bind to biological structures, such as the extracellular matrix, via heparan sulfate without the undesired neutralizing effects on the activity of activin A, myostatin, and GDF11, as full-length follistatin does. The present invention relates to fusion or conjugated proteins, compositions thereof, constructs or vectors encoding them, their medical uses, and methods for biotherapeutics.

The invention belongs to the technical field of gene recombination, and particularly relates to a recombinant human III-type triple helix collagen, a recombinant yeast strain for expressing the recombinant human III-type triple helix collagen and a construction method of the recombinant human III-type triple helix collagen. The amino acid sequence of the recombinant human III-type triple-helix collagen is shown as SEQ ID NO. 1, and the recombinant human III-type triple-helix collagen has triple-helix conformation close to a natural biological structure of collagen and has good application value and potential. According to the recombinant yeast strain disclosed by the invention, human-derived III-type collagen and proline hydroxylase are co-expressed in yeast cells without YPS1 protease, and meanwhile, a gene beneficial to vesicle transport and protein folding is transferred, so that hydroxylation of the recombinant collagen can be realized, a natural triple helix conformation is formed, and the recombinant yeast strain can be used for preparing a recombinant collagen product. The degradation problem of the collagen in the expression process can be solved, and the extracellular secretion expression of the triple helix collagen is realized.

The invention belongs to the technical field of gas sensing, and discloses a preparation method of an indium oxide gas-sensitive material based on a bamboo biological template, which comprises the following steps: taking natural bamboo as a biological structure template, introducing an indium source precursor into a template pore channel by a solution impregnation method, drying, and carrying out high-temperature calcination in an air atmosphere. According to the heat treatment process, thermal degradation and removal of the biological template are achieved, decomposition and oxidation of the precursor are synchronously induced, and finally the indium oxide material with the bamboo biological form and the high specific surface area is generated. The obtained material shows high response and recovery speed to nitrogen dioxide gas, the response value exceeds three thousand, meanwhile, precious metal and a traditional chemical preparation method do not need to be used in the preparation process, and the green chemical concept of saving energy and reducing pollution is achieved.

A patch to be placed over an injury or defect in tissue in a biological structure having a lumen and preventing migration of contents of the biological structure through the injury or the defect. The patch includes an adhesive layer configured to adhere to the biological tissue via formation of hydrogen or covalent bonds with chemical groups present in the biological tissue and a backing layer coupled to and coextensive with the adhesive layer, the backing layer configured to be impervious to the contents.

A biological structure identification system includes an optical imaging system configured to illuminate a liquid biopsy sample for a subject. The liquid biopsy sample has one or more biological structures that are labeled with one or more fluorophores associated with a fluorescence assay for a cancer allowing detection of emitted electromagnetic radiation from the liquid biopsy sample as image data. The system also includes a processing system configured to identify a cancer stage for the subject by determining a predetermined cancer stage profile from a set of predetermined cancer stage profiles to which the subject profile is most similar.

A device for providing a magnetic treatment by evoking muscle contraction by a time-varying magnetic field and providing a RF treatment by heating biological structure. The device includes an applicator having an RF electrode and a magnetic field generating device. The device may also include a main unit, a human machine interface, and a control unit. The control unit adjusts a signal provided to the RF electrode and creates an RF circuit, and also adjusts the signal provided to the magnetic field generating device and creates a magnetic circuit electrically insulated from the RF circuit. The RF circuit may include a power source and a power amplifier, and the magnetic circuit may include an energy storage to supply the magnetic field generating device with electric current.

The invention discloses a structure-enhanced starch-based aerogel capable of improving porosity as well as a preparation method and application thereof, the aerogel comprises enzyme modified starch and natural starch, and the enzyme modified starch is obtained by improving the natural starch by adopting a compound enzyme system composed of multiple amylases. The method comprises the following steps: S1, modifying natural starch through a compound enzyme system to obtain enzyme modified starch; s2, mixing the enzyme modified starch with natural starch in proportion, adding water to form a composite suspension, and performing gelatinization treatment to obtain a gelatinized starch system; and S3, carrying out gelation, freezing and drying treatment on the gelatinized starch system to obtain the aerogel. The aerogel can be applied to thermal insulation materials, adsorption materials, bio-based structural materials or functional porous materials. The molecular structure of the starch is controllably adjusted through the synergistic effect of different enzyme systems, so that the porosity, the structural uniformity and the mechanical stability of the aerogel are remarkably improved on the premise of not introducing a chemical cross-linking agent.

This invention provides a cross-modal translation method, comprising acquiring scRNA-seq data and / or scDNAm data and preprocessing them; performing feature mapping to obtain dimension-aligned low-dimensional potential representations of RNA attributes and / or DNAm attributes; performing cross-modal transformation processing that preserves biological features to obtain low-dimensional features of DNAm attributes and / or RNA attributes; and performing high-dimensional reconstruction processing to obtain scDNAm prediction data and / or scRNA-seq prediction data. The advantages of this invention are that it enables bidirectional cross-modal translation of scRNA-seq and scDNAm, expanding the application scenarios of multi-omics analysis; the cross-modal transformation preserves biological features throughout, ensuring that the generated prediction data closely matches the biological structure of the real data, rather than simply being a numerical fit; and it forms a complete processing link from raw data to prediction data, with the output high-fidelity prediction data directly usable for downstream multi-omics joint analysis and mechanism mining.

The application discloses a preparation method and system of a tendon / ligament-bone junction special trabecular zone biomechanical bidirectional biomimetic bone biological structure, and belongs to the technical field of bone biological material preparation, and comprises the following steps: extracting morphological information of trabeculae and mechanical parameters of a tendon / ligament-bone junction based on a target region of a human specimen slice; determining a biomimetic structure based on the morphological information of the trabeculae; determining a biological material for preparing the biomimetic structure based on the mechanical parameters of the tendon / ligament-bone junction; preparing the biomimetic bone biological structure based on the biomimetic structure and the bone biological material; and performing modification treatment on a surface of the biomimetic bone biological structure to obtain a final biomimetic bone biological structure. The application combines the construction information of the trabeculae of the tendon / ligament-bone junction with 3D printing technology, realizes the structure and material collaborative biomimetic of an implant when the tendon / ligament-bone junction is reconstructed, and provides important technical support for researching and developing a bone biological structure with better biocompatibility for the tendon / ligament-bone junction.

Preparation method and application of branched BODIPY polymer nano-fluorescent probe, belonging to the technical field of nano-fluorescent materials. In the present invention, a polymer chain is synthesized by free radical polymerization, and a fluorescent small molecule compound is combined with the polymer chain through a dehydration condensation reaction to obtain a branched BODIPY polymer, and then the branched BODIPY polymer is prepared into a branched BODIPY polymer nano-fluorescent probe by a nano-precipitation method. The branched BODIPY polymer nano-fluorescent probe prepared by the present invention not only has good dispersibility and stability, and can effectively avoid fluorescence group aggregation-induced luminescence quenching; but also has good imaging effect and can obtain continuous and uniform biological structure images.

Suturing devices and systems used to apply sutures and / or to close openings at, within, or into a biological structure. The suturing device can comprise an elongate member having a proximal end, a distal end, one or more distal arms, one or more proximal extensions, and one or more needles. A sheath may be used with the device to maintain or substantially maintain haemostasis while the device is used and while a procedure is performed in the biological structure.

The application belongs to the technical field of antibacterial medicine, and particularly relates to a polypyridine ruthenium complex with a double-amide biological structure modification and a preparation method and application thereof. The application provides a double-amide structure ruthenium (II) complex, the complex has excellent antibacterial activity on staphylococcus aureus and MRSA, has a unique action mechanism, is not easy to induce drug resistance, has high in-vivo safety, and can be used for treating drug-resistant bacterial infection.

An optical fiber is provided with high mechanical flexibility and truly distributed strain sensing capability along the fiber direction for sensing in-plane mechanical strains on a human body surface or other non-planar biological structure. The optical fiber comprises a self-sensing material configured to emit a spectrum of colored lights upon sensing mechanical strain, without using an independent light source. In embodiments, the optical fiber comprises a polydimethylsiloxane fiber medium and a linear array of copper-doped zinc sulfide (ZnS:Cu) polydimethylsiloxane microdots integrated into a center of the fiber medium, each microdot configured to emit a unique irradiance spectrum due to variations in the composition of the ZnS:Cu particles and / or addition of different colored quantum dots. The ends of the optical fiber are coupled to optical detectors for capturing the multi-colored light emission spectrum and providing corresponding strain sensor data to a processor to generate an in-plane strain mapping along the fiber.

The application discloses a kind of based on graph neural network's protein and ligand between the prediction method of pose of docking pose, first, obtain the biological information sample set of protein-ligand complex, sample set includes sample data and sample annotation data;Second, construct the pose generation model of docking pose based on graph neural network and the pose evaluation model of docking pose based on multi-view, further adjust the parameter of model, the sample data is handled by the structure generation model obtained by training, obtain the pose of protein ligand and actually output;Finally, the stability of output result is evaluated using mainstream pose docking structure evaluation index.This application directly uses the biological structure information of ligand protein to generate the optimal docking pose structure, and evaluates the generation result through multi-angle comprehensive evaluation model, so as to improve the accuracy of ligand-protein pose structure docking prediction, and improve the effectiveness of ligand-protein pose structure docking prediction result evaluation.

The invention relates to the field of anti-seismic design of building structures, and discloses a bionic design method for optimizing the anti-seismic performance of a building structure, which comprises the following steps: step 1, firstly, collecting a biological sample with anti-seismic capacity, and then researching the body structure of a biological sample and the performance of the biological sample in an earthquake; the method comprises the following steps: step 1, selecting an organism with excellent anti-seismic capacity as a bionic object, and step 2, establishing a corresponding mechanical model according to an analysis result of a biological structure through mathematical modeling and mechanical analysis, and converting key anti-seismic characteristics of the selected biological structure into quantitative design parameters. By researching organisms with shock resistance, the stability and reliability of a building structure in an earthquake are remarkably improved, earthquake damage and casualty risks are greatly reduced, meanwhile, intelligent biomimetic materials are integrated at key nodes, earthquake damage is repaired by using a microcapsule repairing agent and a microorganism mineralization mechanism, and the service life of the intelligent biomimetic materials is prolonged. And the integrity and the safety of the structure after the earthquake are ensured.