204 results about "Patient response" patented technology

A ventilator (10) for use by a clinician in supporting a patient presenting pulmonary distress. A controller module (20) with a touch-screen display (26) operates a positive or negative pressure gas source (40) that communicates with the intubated or negative pressure configured patient through valved (46) supply and exhaust ports (42, 44). A variety of peripheral, central, and or supply / exhaust port positioned sensors (54) may be included to measure pressure, volumetric flow rate, gas concentration, transducer, and chest wall breathing work. Innovative modules and routines (30) are incorporated into the controller module enabling hybrid, self-adjusting ventilation protocols and models that are compatible with nearly every conceivable known, contemplated, and prospective technique, and which establish rigorous controls configured to rapidly adapt to even small patient responses with great precision so as to maximize ventilation and recruitment while minimizing risks of injury, atelectasis, and prolonged ventilator days.

A method for gathering medical information sorting it by statistically and medically based rules, and condensing it into a data set which enables medical providers to practice medicine in a more efficient manner. The medical information may be gathered from insurance billing records and patient responses to statistically-validated medical status questionnaires. The patient population may be a defined one, being composed of all patients in a group which is being treated by an individual medical provider or a group of providers at any particular time. The financial transactions to be monitored may be formatted electronically into one or more standard formats as well as medical diagnosis and medical procedure information which has been transmitted in standard codes. These data sets are gathered in electronic format by being copied from the feeder computer system into another computer which does the required rules-based data reduction.

A method useful for facilitating choosing a treatment or treatment regime and for predicting the outcome of a treatment for a disorder which is diagnosed and monitored by a physician or other appropriately trained and licensed professional, such as for example, a psychologist, based upon the symptoms experienced by a patient. Unipolar depression is an example of such a disorder, however the model may find use with other disorders and conditions wherein the patient response to treatment is variable. In the preferred embodiment, the method for predicting patient response includes the steps of performing at least one measurement of a symptom on a patient and measuring that symptom so as to derive a baseline patient profile, such as for example, determining the symptom profile with time; defining a set of a plurality of predictor variables which define the data of the baseline patient profile, wherein the set of predictor variables includes predictive symptoms and a set of treatment options; deriving a model that represents the relationship between patient response and the set of predictor variables; and utilizing the model to predict the response of said patient to a treatment. A neural net architecture is utilized to define a non-linear, second order model which is utilized to analyze the patient data and generate the predictive database from entered patient data.

A generic model structure captures basic characteristics in BIS-based patients' responses to anesthesia and surgical stimulation, the model being used in combination with the insight of an anesthesiologist. The model structure represents the patient response with a time delay, a time constant for response speed, and a nonlinear function for drug sensitivity. Clinical data confirms the model structure and is used to establish parameters and function forms for individual patients. A feedback and predictive control strategy for anesthesia drug infusion is then introduced on the basis of the patient model. Feedback control alone cannot avoid large fluctuations in BIS values when significant surgical stimulation is imposed, as a result of time delays in a patient's response to drug infusion. Predictive control attenuates fluctuations of BIS levels from surgical stimulation.

The present invention provides, among other things, a site specific way to enhance a natural hormonal response to nutrients entering the small intestine after gastric emptying, thereby providing therapeutic value for obesity or diabetic patients. In one aspect, the present invention provides methods of stimulating the release of satiety hormone in a subject comprising applying a first electrical stimulus to a tissue in the lumen of the gastrointestinal system of the subject contemporaneously with the contacting of L-cells of the tissue with a nutrient stimulus. In another aspect, the present invention provides methods for predicting patient response to a weight loss surgery comprising applying a first electrical stimulus to a tissue of the gastrointestinal system of said patient contemporaneously with the contacting of L-cells of the tissue with a nutrient stimulus, assessing the effect of the electrical stimulus in said patient, and, correlating said effect to said patient's response to a weight loss surgery.

Compositions and methods are provided for prognostic classification of autoimmune disease patients into subtypes, which subtypes are informative of the patient's need for therapy and responsiveness to a therapy of interest. The patterns of circulating blood levels of serum autoantibodies and / or cytokines provides for a signature pattern that can identify patients likely to benefit from therapeutic intervention as well as discriminate patients that have a high probability of responsiveness to a therapy from those that have a low probability of responsiveness. Additionally, serum autoantibody and / or cytokine signature patterns can be utilized to monitor responses to therapy. Assessment of this signature pattern of autoantibodies and / or cytokines in a patient thus allows improved methods of care. In one embodiment of the invention, the autoimmune disease is rheumatoid arthritis.

Cardiac treatment methods and devices provide for templates representative of past tachyarrythmia events, each template associated with a therapy. Methods involve providing a cardiac waveform representative of a patient's cardiac activity and identifying a portion that indicates an arrhythmic event. A cardiac template corresponding to the portion is generated, and a therapy is associated with the template useful for treating a subsequent arrhythmia. The waveform portion may be identified by a physician using a patient-external device to display the cardiac waveform. The template may be generated by a physician selecting the cardiac waveform, and determining if the therapy associated with the template was satisfactory and / or effective in treating the arrhythmia. Identification may involve matching the event to templates generated using cardiac waveforms other than the patient's cardiac waveforms. The template may be generated in a patient-internal or patient-external medical device such as a programmer, and / or an advanced patient management system.

Cardiac treatment methods and devices providing templates representative of past tachyarrythmia events, each template associated with a therapy. A cardiac waveform is detected, and if it corresponds to a particular template associated with a previous therapy that was satisfactory in terminating a past event, the previous therapy is delivered again. If unsatisfactory, the previous therapy is eliminated as an option. If, for example, the previous therapy was an antitachycardia pacing therapy unsatisfactory in terminating the past tachyarrythmia event, delivery of the antitachycardia pacing therapy is eliminated as an option. Instead of ATP therapy, one or more of a cardioversion, defibrillation, or alternate anti-tachycardia pacing therapy may be associated with the particular template. Cardiac waveforms and templates may correspond in terms of one or more of morphology, timing, drug regimen, medication, neural activity, patient activity, hemodynamic status, cardiac tissue impedance, transthoracic impedance, or other information corresponding to the episode.

A tissue stimulation device includes an electrode array having at least four independently switchable electrodes. In one embodiment, the electrode array comprises a flexible base to which the electrodes are fixed that flexes to encompass at least a portion of an artery or other elongate biological structure. The electrodes are electrically coupled to and energized by a signal generator coupled to a control system. In one embodiment, the array of electrodes are configured such that a suitable signal pattern for stimulation pulses between or among a set of the switchable electrodes may be determined without having to reposition the electrode assembly by using a series of signal patterns activating different combinations of switchable electrodes in response to sub-stimulation test signals to determine a signal pattern that provides suitable patient response. In another embodiment, the array of electrodes includes an array of selectively activatable multi-polar electrodes.

The present invention is a personal health monitoring system which interactively delivers treatment stimuli and compiles a chronological history of a patient's health. The invention includes personal health diaries for direct measurement of physiological measurement as well as collection subjective responses. The personal health diaries also deliver educational content and health related reminders. The personal health diaries are remotely configured to deliver patient specific display of the treatment information. Patient response information, timing signals are routinely transmitted to the central monitoring system. The central monitoring system is programmed to automatically alert caregivers and family members when responses fall outside patient defined normal ranges. Caregivers and family members can interactive with the central monitoring system to provide updated treatment information as well as personal inspirational content. Through education and appropriate intervention the present invention can improve and maintain the patient's health and extend their independent lifestyle.

Systems and methods are provided for predicting patient response to a therapy regimen for a liver disease or a disease that is treatable with an immunomodulatory disease therapy using gene expression classifiers. Systems and methods for screening for modulators of target gene expression are also provided. Systems and methods for developing therapeutics against one or more of the proteins coded for by genes of the present invention are also provided. Systems and methods for predicting a patient response to a regimen of pegylated interferon alpha and ribavirin in a therapy for hepatitis C viral infection are also provided.

A method of modeling propagation of a pharmaceutical fluid in a patient, includes: collecting data corresponding to a time response curve resulting from injection of the fluid; and determining at least one mathematical model describing the data. The mathematical model can, for example, be a model which is not determined by a continuous or a discrete-time Fourier transform of the data. A method of controlling injection of a pharmaceutical fluid into a patient using an injector in a medical procedure, includes: collecting data corresponding to a patient response curve resulting from injection of the fluid; determining at least one mathematical model describing the data; and controlling the injector during the medical procedure to control injection of the fluid into the patient to create patient response at least in part on the basis of the mathematical model. A method of controlling injection of a contrast medium into a patient using an injector in a medical imaging procedure using an imaging scanner, includes: determining at least one mathematical model to predict a time enhancement response resulting from injection of the contrast medium; determining an injection protocol to approximate a predetermined time enhancement response in the patient by determining a constrained input solution to the mathematical model; and using the injection protocol to control the injector during the medical imaging procedure to control injection of the contrast medium into the patient to create an image of a region of interest.

The methods and apparatus disclosed herein provide digital diagnostics and digital therapeutics to patients. The digital personalized medicine system uses digital data to assess or diagnose symptoms of a patient, and feedback from the patient response to treatment is considered to update the personalized therapeutic interventions. The methods and apparatus disclosed herein can also diagnose and treat cognitive function of a subject, with fewer questions, decreased amounts of time, and determine a plurality of behavioral, neurological or mental health disorders, and provide clinically acceptable sensitivity and specificity in the diagnosis and treatment.

The present invention provides a novel system of hardware designed to capture and process in real time clinical observations of patient responses and reactions in different clinical and patient settings and situations, comprising: a patient biometric data recording system in a clinical office, a mobile real time episode or event data recording device syste or a wearable device recording system.

The invention concerns genes and gene sets and methods useful in the prediction of the response of a cancer patient to treatment with an epidermal growth factor receptor (EGFR) inhibitor.

A ventilator for use by a clinician in supporting a patient presenting pulmonary distress. A controller with a touch-screen display operates a positive or negative pressure gas source that communicates with the intubated or negative pressure configured patient through valved supply and exhaust ports. A variety of peripheral, central, and / or supply / exhaust port positioned sensors may be included to measure pressure, volumetric flow rate, gas concentration, transducer, and chest wall breathing work. Innovative modules and routines are incorporated into the controller module enabling hybrid, self-adjusting ventilation protocols and models that are compatible with nearly every conceivable known, contemplated, and prospective technique, and which establish rigorous controls configured to rapidly adapt to even small patient responses with great precision so as to maximize ventilation and recruitment while minimizing risks of injury, atelectasis, and prolonged ventilator days.

Presented are systems and methods that provide patients with diagnostic measurement tools and clear and concise audio / video guidance to reliably and accurately perform clinical grade diagnostic measurements of key vital signs. In various embodiments, this is accomplished by using an automated remote (or local, e.g., in the form of a kiosk) end-to-end medical diagnostic system that monitors equipment usage for accuracy. The diagnostic system analyzes patient responses, measurement data, and patient-related information to generate diagnostic and / or treatment information that may be shared with healthcare professionals and specialists, as needed. Automation provides for timely, hassle-free, and cost-effective health care management that takes the stress out of doctor visits, while delivering personalized health care. The high accuracy of generated diagnostic data improves health care to patients and reduces the risk of medical malpractice for treating physicians.

A medical monitoring device, operating system, and method are provided for managing administration of medical treatment regimens for treating a patient's medical conditions. The device stores information relating to administered medical treatment regimens, including medication schedule data, treatment data, patient query data, patient response data, and interactively provides information to the patient and health care providers. A method and apparatus for performing real-time monitoring of a patient's health status using the medical monitoring device are also provided. Various aspects of the patient's treatment regimens are modified accordingly. The medical monitoring device further analyzes monitored data in view of predefined criteria, and may promptly communicate information concerning the patient's health status and treatment progress to remote devices that notify health care providers, and may modify the patient's treatment regimens based on results of the analysis.

The invention provides methods and compositions to detect expression of one or more biomarkers for monitoring the effectiveness of treatment of with VEGF antagonists. The invention also provides methods for identifying and treating patients who are likely to be responsive to VEGF antagonist therapy. The invention also provides kits and articles of manufacture for use in the methods.

The present invention is an outpatient monitoring system which enables patients to interact with a health care provider using a standard telephone. A patient is presented with a series of condition-appropriate questions. Based upon the patient responses, additional questions are posed on a real-time dynamic basis. In addition, certain general questions from a predefined set of questions are asked of the patient in a rotating manner to ensure that there is variety with each telephone session. Further, the question sets can be recorded in the voice of the patient's clinician, or other person familiar to the patient, so that a familiar voice is heard by the patient, thereby personalizing the medical experience.

Use of cereblon-associated proteins as biomarkers for clinical sensitivity to cancer, inflammatory diseases, and patient response to drug treatment.

Titration of a combination of drugs or treatment modalities within individual subjects is carried out using an evolutionary operation (EVOP) direct-search procedure such as the Nelder-Mead simplex. Desirability functions are incorporated to define the main response of interest and additional responses or constraints. Statistical methodology for determining whether the titrated treatment combination has resulted in an improvement in patient response and for evaluating whether a therapeutic synergism exists is also incorporated. Inferences can be made about the efficacy of the combination or about the individual drugs or treatment modalities that comprise the combination. This approach allows every patient the potential to benefit from the combination under study and permits the consideration of multiple endpoints simultaneously.

A method of determining a responsiveness of a patient having brain state changes, comprising receiving an indication of a triggering event; administering to the patient, in response to the indication, a test of responsiveness; determining, based upon a result of the test, at least one responsiveness parameter selected from the group consisting of (i) a time of occurrence of a change in the patient's responsiveness, (ii) a duration of a change in the patient's responsiveness; (iii) a magnitude of a change in the patient's responsiveness, (iv) a time interval from the indication of event occurrence to a change in the patient's responsiveness, (v) a type of change in the patient's responsiveness, (vi) an estimation of a seizure severity; (vii) a classification of a seizure into clinical or subclinical; (viii) a classification of a clinical seizure into simple partial, complex partial, or generalized; (ix) an assessment of efficacy of a therapy for the patient's medical condition; (x) an assessment of the state of the disease and formulation of a prognosis for the patient; (xi) an estimation of a risk of injury or death for the patient; and (xii) two or more thereof A medical device system capable of implementing the method.

The present invention provides a system and method for determining and maintaining a concentration level of medication in a patient sufficient to achieve and maintain a desired effect on that patient. Generally speaking, in accordance with one embodiment of the invention, a medication delivery controller uses a patient response profile to determine a concentration of medication in the patient that will achieve the desired effect on the patient. The patient response profile is a graphical, tabular or analytical expression of the relationship between the concentration of a medication and the effect of the medication at the specific concentration. Using this information, the medication delivery controller provides instructions to a medication delivery unit such as, for example, an infusion pump or inhalation device, to deliver the medication to the patient at a rate that will achieve the desired concentration level of the medication in the patient.

An information management and communications system for communication between patients and healthcare providers, including an automated interactive patient response system, and apparatus and software to create, configure, and manage the content and structure of the patient response system to provide secure standards-based outpatient health assessment monitoring, to include disease management, medication compliance, wellness program compliance, and general health screening.

A system for collecting patient screening data is disclosed. The system includes force measuring apparatus for measuring weight and for measuring balance forces, and stimuli delivery apparatus for delivering first stimuli designed to evaluate visual acuity, for delivering second stimuli designed to evaluate hearing acuity, and for accepting patient responses to the first stimuli and the second stimuli. A processing unit is associated with and manages the operation of the force measuring apparatus and the stimuli delivery apparatus for collecting weight and balance force measurements from the force measuring apparatus and patient responses from the stimuli delivery apparatus.

Systems and methods are described for adjusting the operation of implantable stimulation devices used to provide medical monitoring and treatment. Several hierarchical algorithms are described which operate according to conditionally obtaining a patient response to an alert signal. In one such strategy semi-automatic therapy adjustment occurs by automatically issuing patient alert messages when selected operations are to occur, and using a patient's response to the alert message that is provided within a selected time limit in order to contingently adjust therapy. Methods are also described for resolving conflicts which may occur when time information and sensed data information each indicate different patient states are occurring. Although treatment of neural and cardiac disorders is emphasized, the techniques can be applied to the monitoring and treatment of any medical disorder with an implanted device.

A method for classifying cancer patients as eligible to receive cancer therapy with a small molecule inhibitor of Bcl-2 comprising determination of the presence or absence in a patient tissue sample of chromosomal copy number status at the chromosomal locus 13q14 comprising the microRNA's miR-15a and miR-16-1 or at the chromosomal locus 11q23.1 comprising the microRNA miR-34c. The classification of cancer patients based upon the presence or absence of 13q14 loss or gain allows better selection of patients to receive chemotherapy with a small molecule Bcl-2 inhibitor such as N-(4-(4-((2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohex-1-en-1-yl) methyl)piperazin-1-yl)benzoyl)-4-(((1R)-3-(morpholin-4-yl)-1-((phenylsulfanyl) methyl)propyl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide, and for monitoring patient response to this therapy.

An external medical device is provided. The device can include monitoring circuitry configured to sense physiological information of a patient and a controller with one or more input components. The controller can be configured to: detect one or more patient events based, at least in part, on the physiological information; notify the patient of the detection of the one or more patient events; and receive a patient response to the notification. The patient response can include a response activity identifiable by the input component, which is configured to test a psychomotor ability of the patient, cognitive ability of the patient, strength, balance, stability, and flexibility of the patient, and / or to substantially confirm that a person performing the activity is the patient.