158 results about "Chemotherapy" patented technology

The invention relates to the technical field of gastrointestinal tumor chemotherapy risk assessment, and particularly discloses a gastrointestinal tumor chemotherapy risk scoring model and a construction method thereof, and the method comprises the steps: obtaining the individualized feature data and basic physiological data of a historical patient, and constructing an individualized difference library with a unique ID, and a core influence library; the method comprises the following steps: standardizing and coding double-library data, synchronizing clinical data containing treatment effect codes, forming a data dictionary, acquiring and coding current gastrointestinal tumor patient data, and matching the data dictionary to judge individual difference abnormity; when the first data set is abnormal, constructing a first data set, screening core independent variables through Logistic regression, and constructing a scoring model by using an LSTM (Long Short Term Memory) model; when no abnormity exists, redundant codes are removed to obtain a second data set, and modeling is conducted through the same method. Through double-library linkage and scene-divided modeling, the three-level toxicity risk prediction precision is improved, data support is provided for clinical chemotherapy dose adjustment and toxicity prevention, and the risk of excessive treatment or insufficient treatment is reduced.

The invention discloses a platinum (IV)-pirfenidone compound prodrug, a preparation method and microenvironment remodeling anti-tumor application, and belongs to the field of medical technology and drug synthesis. A series of molecules are characterized by being platinum prodrugs modified by pirfenidone derivatives. The synthesis method sequentially comprises the following steps: oxidizing platinum drugs, modifying hydroxyl groups, and introducing pirfenidone derivatives through esterification reaction. A series of molecules are reduced into Pt (II) drugs at the focus to kill cancer cells, and meanwhile, the released pirfenidone derivative can remodel the tumor microenvironment. The platinum prodrug disclosed by the invention not only has excellent cancer cell killing ability, but also is relatively low in drug resistance and excellent in safety, can trigger immunogenic cell death, and is a brand new chemotherapy-immunotherapy method. A series of molecules are convenient to synthesize, the preparation process is simple, and the amphipathicity is excellent, the anti-cancer capability is excellent, the drug resistance and toxicity are low, and the clinical application prospect is good.

The invention discloses a special medical application formula and a preparation method of a selenium-rich ginseng medicinal and edible herbal liquid, and belongs to the technical field of health foods and special medical foods. The formula is prepared from a selenium-enriched ginseng extract, Chinese yam powder, a poria cocos extract, a gordon euryale seed extract, a Chinese date extract, a longan aril extract and auxiliary materials through scientific compatibility, and has the effects of tonifying spleen and kidney, reinforcing qi and nourishing blood aiming at the pathogenesis of spleen and kidney deficiency and deficiency of qi and blood. According to the preparation method, a gradient process combining ultrasonic-assisted ethanol extraction and enzymolysis water extraction is adopted, and active ingredients such as organic selenium, ginseng rare saponin, jujube cAMP and longan polysaccharide are efficiently extracted and reserved. Experiments show that the herbal liquid has a remarkable synergistic effect in the aspects of improving immunity, improving hematopoietic function and resisting fatigue, and is suitable for nutrition support and function conditioning of tumor chemoradiotherapy patients and postoperative weak people.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine electuary for intestinal injury caused by radiotherapy and chemotherapy and a preparation method of the traditional Chinese medicine electuary. According to the composition principle of monarch, minister, assistant and guide of a traditional Chinese medicine prescription, the traditional Chinese medicine electuary is prepared by taking radix astragali preparata as a monarch drug, taking radix codonopsis and rhizoma polygonati as minister drugs, and taking poria cocos, bran-fried rhizoma atractylodis macrocephalae, hairyvein agrimony, Chinese pulsatilla root, rhizoma bletillae and pinellia ternate as assistant drugs, and taking pericarpium citri reticulatae, vinegar-processed curcuma zedoary, pseudo-ginseng and musk as assistant drugs through scientific compatibility and a preparation process. The intestinal function can be adjusted, and the intestinal injury symptom caused by radiotherapy and chemotherapy is improved.

The invention discloses a preparation method of cryptotanshinone-loaded PDA (Polydopamine) nano drug-loaded particles. The technical scheme adopted by the invention is as follows: the cryptotanshinone is loaded on PDA (Polydopamine) nano particles. Photo-thermal therapy and pharmaceutical chemotherapy are integrated into designed nano-delivery to impart a targeted synergistic effect thereto. In addition, the PDA nanoparticles show photoacoustic imaging capability, and aggregation of the nanoparticles at the ovary part can be monitored in real time. The cryptotanshinone is loaded by utilizing aperture adsorption of PDA and pi-pi conjugation and hydrophobic interaction with the cryptotanshinone, so that a drug delivery system is constructed, the biological solubility and the utilization rate of the cryptotanshinone are improved, a slow release effect is achieved, the application of the cryptotanshinone is widened, and the purpose of treating the polycystic ovarian syndrome is achieved.

The application relates to a traditional Chinese medicine composition and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The application provides a traditional Chinese medicine composition which comprises the following components in parts by weight: atractylodes 18-30 parts, luffa retinervus 12-20 parts, black tiger 12-20 parts, incarvillea 12-20 parts, caesalpinia 12-20 parts, astragalus 12-20 parts and silkworm excrement 6-10 parts. The traditional Chinese medicine composition is prepared by matching atractylodes, luffa retinervus, black tiger, incarvillea, caesalpinia, astragalus and silkworm excrement, the efficacy of eliminating phlegm and dampness, removing stasis and toxin, dredging blood vessels, nourishing blood, relieving pain and stopping numbness is strengthened, and the excessive pungent, warm and dry heat of the whole prescription is prevented. The traditional Chinese medicine composition is suitable for relieving numbness, pain and fatigue of tumor patients in the whole process of chemotherapy, targeted therapy and immunotherapy.

The invention discloses a Chinese style image game chemotherapy healing card based on inhabitation hypnosis and a use method, and relates to the technical field of psychotherapy healing tools. The curing card initially contains 55 7 types of function cards (reserved version iteration expansion space), the size of a single card is 60mm * 97mm (adaptive to handheld and board game interaction), the cards respectively correspond to 7 steps of life-inhabitation hypnosis and are matched with exclusive dominant tones, Chinese style natural image patterns corresponding to 30 types of emotions are arranged on the cards, and the Chinese style natural image patterns correspond to 30 types of emotions. A Chinese-style coiled cloth bag (designed according to the size of a 60mm * 97mm card and reserved capacity expansion allowance) and a simple board game instruction book are matched; the using method comprises the five steps of ice breaking, emotion positioning, emotion interpretation, emotion conversion and effect landing and is suitable for single-person, double-person and multi-person scenes, and the core process can be compatible with newly-added cards of subsequent versions. According to the method, through step-color-image three-dimensional corresponding logic, the mode of high-price healing after serious pain is broken through, a user can conduct self-dredging or interactive healing through cards daily, healing is converted into a psychological health preserving mode, the method has the advantages of professionality, culture adaptability, universality and iteration flexibility, and the method is suitable for popularization and application. Tests show that the emotional expression time of a small white case owner can be shortened from 30 minutes to 10 minutes, and the participation rate of family members is increased to 90%.

The application provides a preparation method of high-selenium compound powder for postoperative and radiotherapy rehabilitation immune repair, and belongs to the technical field of functional food or special medical use formula food processing technology.The application realizes sufficient wall breaking by respectively pre-wetting and low-temperature complex enzymolysis of hard plant wall and fungal wall raw materials, and then prevents active loss by using endogenous substances of the raw materials for in-situ anchoring without adding, after drying and crushing, adding postbiotic powder, active peptide, whey protein, yeast beta-glucan, EGCG and other heat-sensitive components into low-temperature sterile dry mixing, while maximizing the release of organic selenium and immune active substances, the heat-sensitive functional components are completely protected from degradation and inactivation, and finally the technical target of sufficient wall breaking, complete activity and stable immune repair effect is achieved.The product prepared by the application can improve the immune organ damage and immune homeostasis imbalance caused by radiotherapy, and is suitable for the immune repair of postoperative and radiotherapy rehabilitation population.

The invention relates to the technical field of evaluation of heart rehabilitation curative effects of breast cancer chemotherapy patients, in particular to a method and system for evaluating the heart rehabilitation curative effects of the breast cancer chemotherapy patients, and the method comprises the following steps: continuously obtaining heart rate variability data and skin conductance data of the breast cancer chemotherapy patients; based on the heart rate variability data and the skin conductance data, the activation state of the autonomic nervous system of the patient is judged; according to the activation state of the autonomic nervous system of the patient, quantifying the intensity and duration of the internal emotional state of the patient, and generating an emotional energy index; when the conventional physiological indexes of the patient fluctuate, determining a physiological fluctuation attribution result in combination with the emotional energy index to distinguish whether the physiological fluctuation is derived from heart function change or emotional influence; and evaluating the cardiac rehabilitation effect of the patient based on the physiological fluctuation attribution result. The accuracy of heart rehabilitation curative effect evaluation can be improved.

The invention relates to the technical field of virtual reality medical treatment, and discloses a head and neck cancer chemoradiotherapy related symptom remote monitoring and multi-sensory intervention method based on VR, and the method comprises the following steps: S1, a patient carries out preliminary evaluation through a first input module of a VR terminal, and transmits monitoring data to a data processing module through the VR terminal; s2, performing secondary evaluation on the average score or the symptom of which any score is in a second interval in a targeted manner through a first input module of the VR end, and sending a multi-sensory first-level intervention request or a multi-sensory second-level intervention request or a multi-sensory third-level intervention request to the VR end by a data processing module according to the score condition of the symptom; and S3, after the patient completes corresponding intervention, performing post-intervention evaluation through the first input module of the VR end, and comparing the evaluation conditions before and after intervention by the data processing module to generate an intervention effect evaluation report. Related symptoms of a patient can be dynamically monitored in real time, symptom changes can be found in time, corresponding intervention is given, treatment interruption is prevented, and the lifetime is prolonged.

The invention relates to the technical field of medical information systems, in particular to a nursing system for tumor patients in a chemoradiotherapy period, which comprises a physiological monitoring module, a threshold evaluation module, a path switching module, a task decomposition module and a nursing scheduling module. According to the method, by continuously collecting multi-dimensional physiological data such as the heart rate, the blood oxygen saturation degree, the blood pressure and the serum creatinine of the patient and conducting noise suppression processing, stable bearing state information can be obtained, and dynamic quantitative evaluation of the tolerance degree is achieved in combination with deviation analysis of the nursing base line; the nursing task is subjected to priority and rhythm adjustment when the bearing index exceeds the limit, the high-load task is split by utilizing fluctuation prediction, and the interval duration is set, so that the risk caused by physiological burden concentration is reduced, the nursing execution rhythm matched with the real-time state of a patient is formed, and the flexibility of load distribution and the instantaneity of intervention response are realized. And the accuracy and safety of whole-course nursing are improved.

The invention discloses mouthwash for treating oral ulcer caused by chemoradiotherapy, which is mainly prepared from the following raw materials in percentage by weight: 0.15 percent to 0.25 percent of chlorhexidine gluconate, 0.015 percent to 0.025 percent of polypeptide of which the amino acid sequence is RWRWRW, 0.05 percent to 0.15 percent of sodium hyaluronate, 0.05 percent to 0.15 percent of menthol, 2.8 percent to 3.2 percent of humectant, 0.45 percent to 0.55 percent of sodium ascorbyl phosphate, 0.5 percent to 1 percent of sodium bicarbonate and the balance of distilled water. The mouthwash for treating the oral ulcer caused by the chemoradiotherapy not only has antibacterial and moisturizing functions, but also can relieve the pain degree of the oral ulcer caused by the chemoradiotherapy, reduce the infection risk and promote ulcer healing, the technical problem that an existing product is single in function is solved, a patient does not need to alternately use multiple preparations, and the compliance is high.

This application relates to the technical field of traditional Chinese medicine compositions, specifically disclosing a traditional Chinese medicine composition for treating deficiency syndromes caused by illness, surgery, radiotherapy, and chemotherapy, and its preparation process. The composition comprises Ganoderma lucidum extract and ginseng powder. The preparation method of the Ganoderma lucidum extract is as follows: Step 1, pulverizing the raw material to obtain Ganoderma lucidum powder; Step 2, extraction: extracting the Ganoderma lucidum powder with a primary liquid-liquid phase solvent for 1.5-2.5 hours, adding non-oxidizing gas nano-bubble water and extracting for 0.5-1.5 hours, then adding acidic gas nano-bubble water and continuing extraction for 0.5-1.5 hours; Step 3, collection: collecting the extract, concentrating, forming a paste, and drying to obtain the Ganoderma lucidum extract; the primary liquid-liquid phase solvent includes an alcohol solution with a volume ratio of (2-5):1 and a non-polar organic solvent, with the alcohol volume percentage in the primary alcohol solution being 65-90%. The composition of this application has a higher content of Ganoderma lucidum polysaccharides and Ganoderma lucidum triterpenes.

The disclosure provides a method of treating a human subject afflicted with lung cancer with a lymphocyte activation gene-3 (LAG-3) antagonist. In some aspects, the method comprises combination of the LAG-3 antagonist with an additional therapeutic agent (e.g., a programmed death-1 pathway inhibitor) and / or anti-cancer therapy (e.g., chemotherapy such as a platinum doublet chemotherapy).

The invention relates to the technical field of ginger moxibustion, in particular to a portable temperature-controllable ginger moxibustion device for arresting vomiting of tumor patients, which comprises a shell, a tube is fixedly connected to the inner side wall of the shell, a pore plate is fixedly connected to the bottom of the tube, a temperature sensor is mounted on the inner side wall of the tube, and a cover is in threaded connection to the top of the shell. A cylinder is fixedly connected to the bottom of the cover body, and an electric heating rod is mounted at the bottom of the cylinder; the electric heating rod is used for simulating heating power of moxa in traditional ginger-separated moxibustion, controllable heating power is used for exciting drug efficacy of ginger of ginger slices on the pore plate, the synergistic effect mechanism that ginger penetrates through heating power and drug efficacy enters the acupoint is perfectly rescribed, the device is designed according to the core requirement of descending adverse-rising energy and arresting vomiting of tumor patients, the device can accurately act on related acupoints for arresting vomiting, and the effect is achieved. The symptoms of nausea and vomiting caused by chemoradiotherapy and the like are effectively relieved.

1. The name of the design product: arm protection sleeve (PICC care with modular). 2. The use of the design product: for providing arm catheter protection and comfortable support for peripheral intravenous central catheter (PICC) chemotherapy patients, reducing the external force effect of daily activities and sleeping posture on the catheter. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

The disclosure relates to targeted Chromatin Accessibility and Mutation Sequencing (tCAM-seq) for parallel analysis of genetic and epigenetic analysis of patients with pancreatic adenocarcinoma (PDAC) to 1) determine responsiveness to standard of care chemotherapy, and 2) identify actionable allelic variant mutations that can be used to guide treatment decisions. Prognostic methods and treatment strategies are also provided.

Methods for treating hormonally driven disorders by administering the PI3K / mT0R inhibitor gedatolisib in combination with hormone therapy are provided. Hormonally driven disorders include, for example, prostate cancer and endometrial disorders. The treatment regimens can also include additional therapies, such as chemotherapy, surgery and / or administration of an immune checkpoint inhibitor(s), a receptor tyrosine kinase inhibitor, a CDK 4 / 6 inhibitor or an epigenetic-targeted therapy.

The application relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine compound preparation for treating solid tumors and promoting blood circulation to remove blood stasis and a preparation method and application thereof. Under the guidance of traditional Chinese medicine theory, according to the syndrome manifestations of patients with solid tumors (early, middle and late stages), the traditional Chinese medicine compound preparation prepared from the animal traditional Chinese medicines gecko, sea squirts and leeches and the plant traditional Chinese medicines notoginseng, madder, safflower and licorice in a certain proportion is used to treat patients with blood stasis syndrome of malignant tumors, can obviously improve the life quality of the patients, reduce the toxic and side effects of radiotherapy and chemotherapy, prolong the survival period of the patients and improve the symptoms of blood stasis syndrome of the patients.

The present invention relates to methods of treating previously untreated diffuse large B-cell lymphoma (DLBCL) defined as high risk according to circulating tumor DNA (ctDNA) by administering galatifamab in combination with chemotherapy.

A method, system, device, and medium for processing symptom cluster data of head and neck cancer patients based on sentinel symptoms are disclosed. The method includes: obtaining symptom data of head and neck cancer patients during radiotherapy and chemotherapy through longitudinal surveys; processing the symptom data using exploratory factor analysis to extract several symptom clusters; performing association rule analysis on the symptom cluster data based on the Apriori algorithm, and determining the sentinel symptoms within each symptom cluster by combining the time of first symptom appearance; and constructing an intervention plan for gastrointestinal symptoms using the sentinel symptoms as intervention targets. This invention achieves accurate determination of sentinel symptoms through longitudinal survey data, combined with the Apriori algorithm and the time of first symptom appearance, and constructs intervention plans based on the MRC complex intervention framework, realizing early symptom identification and providing precise and personalized symptom management support for head and neck cancer patients.

The invention discloses an intelligent exosmosis prevention device for a drug delivery connector. According to the device, connector exosmosis is blocked through a leakage capturing cavity and an elastic ring, liquid is directed to a humidity-sensitive expansion core through a capillary drainage strip so as to drive a pressing block to press and close a flexible clamping and closing section, and visual prompt is achieved through cooperation of an outer ring developing layer of the expansion core and a transparent control part. Therefore, early-stage blocking, automatic cutoff and high visual alarm are achieved, and the safety of chemotherapy infusion is improved. The infusion device is characterized by comprising an infusion assembly, a connecting assembly and an anti-seepage assembly, the infusion assembly comprises an infusion tube, a conveying tube and an indwelling needle connector, the infusion tube is clamped at the open end of the conveying tube, the infusion tube is communicated with the conveying tube, the other end of the conveying tube is of a conical structure and connected with one end of the indwelling needle connector, and the other end of the indwelling needle connector is connected with the connecting assembly. The conveying pipe is communicated with the remaining needle connector, and the connecting assembly comprises a limiting groove, a connecting piece, a limiting ring, a leakage catching cavity and an elastic ring.

The invention discloses a traditional Chinese medicine composition for treating chemotherapy-related oral mucositis and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 6-12 parts of radix rehmanniae recen, 6-12 parts of radix ophiopogonis, 6-12 parts of radix scrophulariae, 6-12 parts of honeysuckle, 6-12 parts of fructus forsythiae, 3-7 parts of radix scutellariae, 1-3 parts of lotus plumule, 3-7 parts of mint and 3-7 parts of borneol. The composition has the effects of nourishing yin, clearing heat, astringing sores and promoting tissue regeneration, and clinical tests prove that the composition can remarkably reduce the occurrence rate of chemotherapy-related oral mucositis of hematological malignancy patients, relieve the damage degree of oral mucosa, shorten the lasting time of ulcer and pain and effectively improve clinical symptoms of traditional Chinese medicine, and is high in safety.

The invention discloses application of rehmannia D in preparation of a product for preventing and / or treating myocardial injury, and belongs to the technical field of medicines. The myocardial injury comprises myocardial injury induced by doxorubicin (DOX), and experiments prove that the rehmannia D can obviously improve the heart function decline caused by the DOX; the myocardial cell atrophy induced by DOX can be obviously inhibited; the level of myocardial tissue fibrosis induced by DOX can be obviously inhibited; the DOX-induced myocardial tissue oxidative stress level can be obviously inhibited; in addition, DOX-induced myocardial tissue DNA damage (gamma-H2AX is taken as a marker) can be obviously inhibited. The invention proves that the rehmannia glycoside D can be used as a novel treatment means to be applied to treatment of adriamycin-induced myocardial injury, and the risk of treatment interruption or heart failure due to cardiotoxicity caused by chemotherapy of a patient can be possibly reduced, so that the disease burden of the patient and the pressure of a medical system are relieved.

This invention belongs to the field of traditional Chinese medicine technology, specifically relating to the application of a formula for nourishing vital energy and strengthening the body in reducing the toxicity of adjuvant chemotherapy after radical resection of non-small cell lung cancer. This invention discloses a formula for nourishing vital energy and strengthening the body, characterized in that it is composed of the following components by weight: 15-30 parts raw Astragalus membranaceus, 9-21 parts prepared Rehmannia glutinosa, 15-30 parts stir-fried Dioscorea opposita, 9-15 parts Atractylodes macrocephala, 9-15 parts Poria cocos, 15-30 parts raw Coix lacryma-jobi, 9-15 parts Ophiopogon japonicus, 9-15 parts Asparagus cochinchinensis, 15-30 parts Adenophora stricta, 9-15 parts Ligustrum lucidum, 9-15 parts Eclipta prostrata, 9-15 parts stir-fried germinated barley, 9-15 parts stir-fried malt, and 3-6 parts prepared Glycyrrhiza uralensis. This invention can restore vital energy, reverse postoperative weakness, build a foundation for chemotherapy tolerance to reduce toxic side effects, improve chemotherapy tolerance, reduce the risk of interruption to ensure efficacy, improve quality of life during chemotherapy, and help prolong postoperative survival.

The application provides application of a selective splicing factor SF3A2 as a biomarker in preparation of a reagent for breast cancer diagnosis, treatment, prognosis evaluation and chemotherapy sensitivity evaluation. The application provides application of a detection reagent for expression level of a selective splicing factor SF3A2 gene or protein in preparation of a kit for breast cancer diagnosis, prognosis evaluation and chemotherapy sensitivity evaluation. Further, the application provides application of an expression inhibitor for a selective splicing factor SF3A2 gene or protein in preparation of a kit for breast cancer treatment and chemotherapy sensitivity improvement.

This invention belongs to the field of biomedical technology, specifically relating to triptolide liposomes (TP-lipo), their combined use, and their application in the prevention and treatment of tumors. To enhance the efficacy of triptolide in the treatment and prevention of tumors such as pancreatic cancer, cervical cancer, ovarian cancer, and colorectal cancer, and to improve its bioavailability and clinical application while reducing toxicity, this invention uses HSPC, DOPS, and cholesterol as liposome components to encapsulate triptolide monomers, thus preparing TP-lipo. Experiments have shown that TP-lipo exhibits anti-tumor activity: it directly kills tumor cells and reverses the immunosuppressive microenvironment, making it a potential drug for tumor treatment. TP-lipo, when used in combination with PD-1 antibodies, or in combination with radiotherapy, chemotherapy, or surgery, demonstrates a potent and synergistic anti-tumor effect with low toxicity. Therefore, the TP-lipo of this invention provides more clinical strategies for tumor treatment.

The invention provides a tool for intelligently evaluating the dystrophy risk of a patient with nasopharyngeal carcinoma, and the tool for evaluating the specific dystrophy of nasopharyngeal carcinoma is constructed by integrating indexes such as social demographic data, physique measurement, tumor staging, chemoradiotherapy conditions, recent adverse reactions and hematology indexes, so that high-precision risk evaluation is realized. Through single-factor and multi-factor analysis, the variable weight is optimized, and the discrimination capability and stability of the model are improved. An intelligent applet based on artificial intelligence is developed, patient data are extracted, nutrition risk calculation is completed within seconds, evaluation time is shortened, and clinical working efficiency is improved. The system also has the functions of dynamic monitoring and intelligent early warning, automatically updates the evaluation result along with the treatment progress of the patient, and provides individualized intervention suggestions. The defects that a traditional nutrition evaluation tool is high in subjectivity, low in efficiency, lack of tumor specificity and low in informatization degree are overcome, and an efficient, accurate and automatic intelligent evaluation solution is provided for clinic.

The invention discloses a stem cell exosome composition for improving premature ovarian failure as well as a preparation method and application of the stem cell exosome composition. The composition is composed of human umbilical cord mesenchymal stem cell exosomes obtained through hypoxia and TGF-beta1 combined pretreatment and resveratrol, and the human umbilical cord mesenchymal stem cell exosomes and the resveratrol are compounded according to a specific mass ratio. The pre-treatment condition is that 1% oxygen concentration and 10 ng / ml TGF-beta1 are co-cultured for 48 hours, and the condition can synergistically up-regulate the expression level of specific miRNA in the exosome. The composition prepared through physical incubation and an ultrafiltration method shows a clear synergistic treatment effect in vitro and in vivo, the combination index of the composition is 0.38-0.45, ovarian endocrine indexes can be effectively recovered, follicular reserve can be protected, and oxidative stress and inflammation states of ovarian tissues can be remarkably improved. The invention provides a novel treatment strategy with a novel mechanism and a remarkable curative effect for premature ovarian failure, especially chemotherapy-induced ovarian function impairment.