260 results about "Chemotherapy" patented technology

The disclosure provides a method for treating a subject afflicted with a tumor, e.g., derived from a non-small cell lung cancer (NSCLC), comprising administering to the subject a combination of a (a) chemotherapy, (b) an anti-PD-1 antibody or an anti-PD-L1 antibody, and (c) an anti-CTLA-4 antibody, wherein the chemotherapy is administered for a period of time that is less than the standard.

The invention belongs to the technical field of medicines, cosmetics and scalp care, and particularly relates to application of coniferaldehydes and derivatives or salts of the coniferaldehydes to preparation of medicines and cosmetics for promoting hair regeneration and treating chemotherapy-induced alopecia (CIA, CIA) and other types of alopecia, in particular to application of the coniferaldehydes and the derivatives or salts of the coniferaldehydes to preparation of the medicines and the cosmetics. Experimental results show that coniferyl aldehyde can promote hair regeneration of mice, accelerate hair growth of the mice and effectively relieve alopecia symptoms of the mice after chemotherapy, and the effect of coniferyl aldehyde is better than that of minoxidil. According to the application, coniferyl aldehyde or a composition thereof is given to a subject, so that the vigor of hair follicles is remarkably enhanced, the stationary period of the hair follicles is shortened, and the hair loss process is inhibited. The coniferyl aldehyde provided by the invention has the industrial application advantages of reliable biological safety, controllable preparation cost and high raw material accessibility, can be obtained by a plant extraction or chemical synthesis method, is suitable for an external solution, gel or a scalp care preparation, and provides a natural, safe and effective solution for alopecia patients.

The present invention relates to nitrogen-containing derivatives of narasin having the formula (I), as well as synthesis and uses thereof, in particular for the treatment and / or prevention of cancer. Also disclosed are medicaments including the nitrogen-containing derivatives of narasin, which include medicaments for preventing cancer metastasis and / or for preventing cancer recurrence and / or for decreasing resistance to a chemotherapy in a subject.

The invention relates to a breast cancer chemotherapy myocardial stress quantitative evaluation method, which comprises the following steps of: acquiring an electromechanical response signal of a myocardial tissue of a chemotherapy patient in a pulsation period, extracting an electromechanical coupling delay parameter of a local tissue, and identifying an initial region of a chemotherapy-induced myocardial stress reaction; for the identified stress starting region and the adjacent cardiac muscle tissue, acquiring the transcellular membrane response time difference, and calculating a stress conduction lag difference index for characterizing the chemotherapy-induced asymmetric stress conduction characteristic; controllable micro-load intervention is carried out on a patient, and a strain reaction curve of a stress starting area and peripheral tissues after the load is applied is monitored; based on the response lag time, the strain peak change rate and the dynamic trend of recovering to the baseline in the load response process, the stress response elastic coefficient of the myocardial tissue is obtained through inversion and is used for quantifying the stress level of the myocardial after breast cancer chemotherapy; tiny changes of myocardial functions are quantified, and a trend judgment basis is provided.

The invention discloses a culture system, culture method and application of gastrointestinal tumor chemotherapy drug-resistant organoid, the culture system comprises: a basic culture medium, which is a DMEM / F12 culture medium, and is additionally added with a special growth promoting factor obtained from a natural extract; the multiple growth factors comprise an epidermal growth factor (EGF), a fibroblast growth factor (FGF), a bone morphogenetic protein (BMP) and a vascular endothelial growth factor receptor inhibitor (VEGFRi), and the concentration of each growth factor is accurately screened and optimized; the extracellular matrix is Matrigel modified by physical and chemical methods; the specific additive comprises an antioxidant N-acetylcysteine (NAC). According to the culture system, the culture method and the application of the gastrointestinal tumor chemotherapy drug-resistant organoid, the culture system which is closer to a real environment in vivo is constructed by optimizing basic culture medium components, setting various growth factors and specific additive concentrations and adopting modified Matrigel as an extracellular matrix.

The invention relates to the technical field of gastrointestinal tumor chemotherapy risk assessment, and particularly discloses a gastrointestinal tumor chemotherapy risk scoring model and a construction method thereof, and the method comprises the steps: obtaining the individualized feature data and basic physiological data of a historical patient, and constructing an individualized difference library with a unique ID, and a core influence library; the method comprises the following steps: standardizing and coding double-library data, synchronizing clinical data containing treatment effect codes, forming a data dictionary, acquiring and coding current gastrointestinal tumor patient data, and matching the data dictionary to judge individual difference abnormity; when the first data set is abnormal, constructing a first data set, screening core independent variables through Logistic regression, and constructing a scoring model by using an LSTM (Long Short Term Memory) model; when no abnormity exists, redundant codes are removed to obtain a second data set, and modeling is conducted through the same method. Through double-library linkage and scene-divided modeling, the three-level toxicity risk prediction precision is improved, data support is provided for clinical chemotherapy dose adjustment and toxicity prevention, and the risk of excessive treatment or insufficient treatment is reduced.

The invention discloses an intelligent pulse acupoint electrode stimulation radiotherapy and chemotherapy side effect relieving device, and relates to the technical field of medical auxiliary equipment, the intelligent pulse acupoint electrode stimulation radiotherapy and chemotherapy side effect relieving device comprises a machine body and an electric pulse therapeutic apparatus main body, one side of the electric pulse therapeutic apparatus main body is provided with two sockets, and two connectors are movably inserted into the two sockets; one ends of the two connectors are connected with four electrode patches through two connecting wires. According to the device for relieving side effects of radiotherapy and chemotherapy through intelligent pulse acupoint electrode stimulation, by arranging an intelligent limiting anti-falling mechanism, stable limiting of one or two connectors is achieved, and the problem that in the using process of an existing electric pulse therapeutic instrument device, the existing electric pulse therapeutic instrument device is not prone to falling off is solved. In the prior art, a connecting port on an electric pulse therapeutic apparatus is often connected with a connecting wire through a connector in an inserted manner, but the connecting wire is easy to loosen and fall off from the electric pulse therapeutic apparatus due to pulling, friction or vibration of an external force in the therapeutic process of a user, and the therapeutic continuity is further influenced.

The invention discloses lactobacillus acidophilus for relieving chemotherapeutic diarrhea and improving constipation and application of the lactobacillus acidophilus, and relates to the technical field of microorganisms. According to the invention, a strain of Lactobacillus acidophilus LIHUO 1978 is screened out, and the preservation number of the Lactobacillus acidophilus is GDMCC No: 65514. The lactobacillus acidophilus LIHUO 1978 has good safety, in-vitro probiotic characteristics and in-vitro immunoregulation characteristics, has the effects of relieving chemotherapeutic diarrhea, improving constipation and regulating intestinal flora, and has good application prospects in preparation of drugs for relieving chemotherapeutic diarrhea and / or preparation of products for improving constipation and regulating intestinal flora.

The invention discloses a platinum (IV)-pirfenidone compound prodrug, a preparation method and microenvironment remodeling anti-tumor application, and belongs to the field of medical technology and drug synthesis. A series of molecules are characterized by being platinum prodrugs modified by pirfenidone derivatives. The synthesis method sequentially comprises the following steps: oxidizing platinum drugs, modifying hydroxyl groups, and introducing pirfenidone derivatives through esterification reaction. A series of molecules are reduced into Pt (II) drugs at the focus to kill cancer cells, and meanwhile, the released pirfenidone derivative can remodel the tumor microenvironment. The platinum prodrug disclosed by the invention not only has excellent cancer cell killing ability, but also is relatively low in drug resistance and excellent in safety, can trigger immunogenic cell death, and is a brand new chemotherapy-immunotherapy method. A series of molecules are convenient to synthesize, the preparation process is simple, and the amphipathicity is excellent, the anti-cancer capability is excellent, the drug resistance and toxicity are low, and the clinical application prospect is good.

The invention discloses a special medical application formula and a preparation method of a selenium-rich ginseng medicinal and edible herbal liquid, and belongs to the technical field of health foods and special medical foods. The formula is prepared from a selenium-enriched ginseng extract, Chinese yam powder, a poria cocos extract, a gordon euryale seed extract, a Chinese date extract, a longan aril extract and auxiliary materials through scientific compatibility, and has the effects of tonifying spleen and kidney, reinforcing qi and nourishing blood aiming at the pathogenesis of spleen and kidney deficiency and deficiency of qi and blood. According to the preparation method, a gradient process combining ultrasonic-assisted ethanol extraction and enzymolysis water extraction is adopted, and active ingredients such as organic selenium, ginseng rare saponin, jujube cAMP and longan polysaccharide are efficiently extracted and reserved. Experiments show that the herbal liquid has a remarkable synergistic effect in the aspects of improving immunity, improving hematopoietic function and resisting fatigue, and is suitable for nutrition support and function conditioning of tumor chemoradiotherapy patients and postoperative weak people.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine electuary for intestinal injury caused by radiotherapy and chemotherapy and a preparation method of the traditional Chinese medicine electuary. According to the composition principle of monarch, minister, assistant and guide of a traditional Chinese medicine prescription, the traditional Chinese medicine electuary is prepared by taking radix astragali preparata as a monarch drug, taking radix codonopsis and rhizoma polygonati as minister drugs, and taking poria cocos, bran-fried rhizoma atractylodis macrocephalae, hairyvein agrimony, Chinese pulsatilla root, rhizoma bletillae and pinellia ternate as assistant drugs, and taking pericarpium citri reticulatae, vinegar-processed curcuma zedoary, pseudo-ginseng and musk as assistant drugs through scientific compatibility and a preparation process. The intestinal function can be adjusted, and the intestinal injury symptom caused by radiotherapy and chemotherapy is improved.

The invention discloses a preparation method of cryptotanshinone-loaded PDA (Polydopamine) nano drug-loaded particles. The technical scheme adopted by the invention is as follows: the cryptotanshinone is loaded on PDA (Polydopamine) nano particles. Photo-thermal therapy and pharmaceutical chemotherapy are integrated into designed nano-delivery to impart a targeted synergistic effect thereto. In addition, the PDA nanoparticles show photoacoustic imaging capability, and aggregation of the nanoparticles at the ovary part can be monitored in real time. The cryptotanshinone is loaded by utilizing aperture adsorption of PDA and pi-pi conjugation and hydrophobic interaction with the cryptotanshinone, so that a drug delivery system is constructed, the biological solubility and the utilization rate of the cryptotanshinone are improved, a slow release effect is achieved, the application of the cryptotanshinone is widened, and the purpose of treating the polycystic ovarian syndrome is achieved.

The invention relates to the technical field of adjuvant chemotherapy, and discloses a breast cancer adjuvant chemotherapy device which comprises a supporting mechanism, the supporting mechanism comprises a supporting frame, supporting legs are fixedly connected to the outer wall of the bottom of the supporting frame, and a headrest is fixedly connected to the outer wall of the top of the supporting frame. A patient needs to lie on the supporting mechanism, after the head is placed in a headrest area, a first auxiliary motor drives a rotating shaft to drive a first sliding frame to slide, then a treatment area of the chest of the patient is accurately found, and a second auxiliary motor drives a rotating wheel to slide on the inner wall of a first sliding groove; and a second telescopic rod pushes a second sliding frame to move, so that the chest chemotherapy equipment arrives at a proper position, radioactive therapy is carried out on a focus of the chest of a patient, then treatment omission can be avoided, and the risk of breast cancer recurrence is practically reduced.

The application discloses a medical hollow tube positioning and marking device and belongs to the technical field of breast tumor marking. The device comprises a head, a fixing ring, an inner core, a hollow flexible tube and a needle cylinder. The fixing ring is fixed at intervals on the hollow flexible tube to form a long chain. The head is fixed at the head end of the long chain to form a marking body. The inner core penetrates into the hollow flexible tube to the head end to push the marking body to move in the needle cylinder. The front end of the needle cylinder is provided with a needle part. After puncture, the needle cylinder and the inner core are used to push the head outward and the marking body is pushed out and positioned. The marking body exposed outside is cut off. Multi-directional marking is used to form stereoscopic, linear and visual positioning. The marking body can be freely bent and is not easy to be cut off and displaced. The risk of infection or accidental injury caused by a traditional positioning steel wire is reduced. Breast cancer patients receiving neoadjuvant chemotherapy only need to be positioned and marked once and do not need to bear the secondary trauma of steel wire positioning again after traditional marking clamp marking.

The application relates to a traditional Chinese medicine composition and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The application provides a traditional Chinese medicine composition which comprises the following components in parts by weight: atractylodes 18-30 parts, luffa retinervus 12-20 parts, black tiger 12-20 parts, incarvillea 12-20 parts, caesalpinia 12-20 parts, astragalus 12-20 parts and silkworm excrement 6-10 parts. The traditional Chinese medicine composition is prepared by matching atractylodes, luffa retinervus, black tiger, incarvillea, caesalpinia, astragalus and silkworm excrement, the efficacy of eliminating phlegm and dampness, removing stasis and toxin, dredging blood vessels, nourishing blood, relieving pain and stopping numbness is strengthened, and the excessive pungent, warm and dry heat of the whole prescription is prevented. The traditional Chinese medicine composition is suitable for relieving numbness, pain and fatigue of tumor patients in the whole process of chemotherapy, targeted therapy and immunotherapy.

The invention relates to a device and method for thermal therapy of a selected region of a human or animal body, particularly for treating tissue damage after surgery, injuries, inflammation, chronic rheumatic conditions, and for supporting chemotherapy. The system includes a temperature control device that circulates a temperature-controlled fluid through a heat transfer unit configured for uniform skin contact, and a pressure device to optimize thermal transfer. During chemotherapy, the device maintains the selected region, such as hands or feet, at a target temperature to prevent or reduce chemotherapy-induced polyneuropathy (CIPN). Sensors monitor temperature and pressure, enabling feedback control for consistent therapy. Methods include fitting the device to the patient, adjusting pressure, and maintaining even skin cooling throughout chemotherapy, thereby improving patient comfort, reducing adverse side effects, and supporting adherence to treatment. The invention provides improved outcomes in thermal therapy applications.

To provide dosing regimens for administering a HIF prolyl hydroxylase inhibitor in the treatment or prevention of anemia, such as anemia secondary to or associated with chronic kidney disease, or anemia associated with or resulting from chemotherapy.SOLUTION: A pharmaceutical composition in a form of a tablet or capsule comprising Compound 1 having the following structure, for use in a method of increasing hemoglobin levels in a patient in need thereof relative to a baseline hemoglobin level, wherein the patient has a hemoglobin level of ≤10.5 g / dL or ≥9.5 g / dL and ≤12 g / dL at a start of treatment, a serum hemoglobin level increases by at least about 0.1 to about 1.0 g / dL relative to the baseline hemoglobin level, and the pharmaceutical composition is used such that Compound 1 is administered to the patient once daily, for example at a dose of about 150 mg.SELECTED DRAWING: Figure 1a

The invention discloses a Chinese style image game chemotherapy healing card based on inhabitation hypnosis and a use method, and relates to the technical field of psychotherapy healing tools. The curing card initially contains 55 7 types of function cards (reserved version iteration expansion space), the size of a single card is 60mm * 97mm (adaptive to handheld and board game interaction), the cards respectively correspond to 7 steps of life-inhabitation hypnosis and are matched with exclusive dominant tones, Chinese style natural image patterns corresponding to 30 types of emotions are arranged on the cards, and the Chinese style natural image patterns correspond to 30 types of emotions. A Chinese-style coiled cloth bag (designed according to the size of a 60mm * 97mm card and reserved capacity expansion allowance) and a simple board game instruction book are matched; the using method comprises the five steps of ice breaking, emotion positioning, emotion interpretation, emotion conversion and effect landing and is suitable for single-person, double-person and multi-person scenes, and the core process can be compatible with newly-added cards of subsequent versions. According to the method, through step-color-image three-dimensional corresponding logic, the mode of high-price healing after serious pain is broken through, a user can conduct self-dredging or interactive healing through cards daily, healing is converted into a psychological health preserving mode, the method has the advantages of professionality, culture adaptability, universality and iteration flexibility, and the method is suitable for popularization and application. Tests show that the emotional expression time of a small white case owner can be shortened from 30 minutes to 10 minutes, and the participation rate of family members is increased to 90%.

The application provides a preparation method of high-selenium compound powder for postoperative and radiotherapy rehabilitation immune repair, and belongs to the technical field of functional food or special medical use formula food processing technology.The application realizes sufficient wall breaking by respectively pre-wetting and low-temperature complex enzymolysis of hard plant wall and fungal wall raw materials, and then prevents active loss by using endogenous substances of the raw materials for in-situ anchoring without adding, after drying and crushing, adding postbiotic powder, active peptide, whey protein, yeast beta-glucan, EGCG and other heat-sensitive components into low-temperature sterile dry mixing, while maximizing the release of organic selenium and immune active substances, the heat-sensitive functional components are completely protected from degradation and inactivation, and finally the technical target of sufficient wall breaking, complete activity and stable immune repair effect is achieved.The product prepared by the application can improve the immune organ damage and immune homeostasis imbalance caused by radiotherapy, and is suitable for the immune repair of postoperative and radiotherapy rehabilitation population.

The invention relates to the technical field of evaluation of heart rehabilitation curative effects of breast cancer chemotherapy patients, in particular to a method and system for evaluating the heart rehabilitation curative effects of the breast cancer chemotherapy patients, and the method comprises the following steps: continuously obtaining heart rate variability data and skin conductance data of the breast cancer chemotherapy patients; based on the heart rate variability data and the skin conductance data, the activation state of the autonomic nervous system of the patient is judged; according to the activation state of the autonomic nervous system of the patient, quantifying the intensity and duration of the internal emotional state of the patient, and generating an emotional energy index; when the conventional physiological indexes of the patient fluctuate, determining a physiological fluctuation attribution result in combination with the emotional energy index to distinguish whether the physiological fluctuation is derived from heart function change or emotional influence; and evaluating the cardiac rehabilitation effect of the patient based on the physiological fluctuation attribution result. The accuracy of heart rehabilitation curative effect evaluation can be improved.

The invention relates to the technical field of virtual reality medical treatment, and discloses a head and neck cancer chemoradiotherapy related symptom remote monitoring and multi-sensory intervention method based on VR, and the method comprises the following steps: S1, a patient carries out preliminary evaluation through a first input module of a VR terminal, and transmits monitoring data to a data processing module through the VR terminal; s2, performing secondary evaluation on the average score or the symptom of which any score is in a second interval in a targeted manner through a first input module of the VR end, and sending a multi-sensory first-level intervention request or a multi-sensory second-level intervention request or a multi-sensory third-level intervention request to the VR end by a data processing module according to the score condition of the symptom; and S3, after the patient completes corresponding intervention, performing post-intervention evaluation through the first input module of the VR end, and comparing the evaluation conditions before and after intervention by the data processing module to generate an intervention effect evaluation report. Related symptoms of a patient can be dynamically monitored in real time, symptom changes can be found in time, corresponding intervention is given, treatment interruption is prevented, and the lifetime is prolonged.

The invention relates to the technical field of medical information systems, in particular to a nursing system for tumor patients in a chemoradiotherapy period, which comprises a physiological monitoring module, a threshold evaluation module, a path switching module, a task decomposition module and a nursing scheduling module. According to the method, by continuously collecting multi-dimensional physiological data such as the heart rate, the blood oxygen saturation degree, the blood pressure and the serum creatinine of the patient and conducting noise suppression processing, stable bearing state information can be obtained, and dynamic quantitative evaluation of the tolerance degree is achieved in combination with deviation analysis of the nursing base line; the nursing task is subjected to priority and rhythm adjustment when the bearing index exceeds the limit, the high-load task is split by utilizing fluctuation prediction, and the interval duration is set, so that the risk caused by physiological burden concentration is reduced, the nursing execution rhythm matched with the real-time state of a patient is formed, and the flexibility of load distribution and the instantaneity of intervention response are realized. And the accuracy and safety of whole-course nursing are improved.

The invention discloses a myeloma patient blood sample sampling auxiliary device based on LDH induced chemotherapy. The myeloma patient blood sample sampling auxiliary device comprises a base; the two ends of the top of the base are each provided with a pressing and holding mechanism used for fixing an arm, and one end of the top of the base is provided with a pulse pressing mechanism used for puncturing the arm. Through the arrangement of the pressing mechanism, the stability of sampling a blood sample of a myeloma patient is improved, the situation that a needle head cannot pierce a designated position can be avoided, and the situations that the needle head falls off and pierces slightly in the sampling process are prevented; the pressing and holding mechanism is matched with the pulse pressing mechanism, so that the large arm position and the small arm position in the arm can be pressed down and positioned at the same time, and medical staff can directly carry out sampling operation after disinfecting the sampling position of the arm and cannot freely do actions after the arm of a patient is fixed; at the moment, the pipeline with the needle head is directly punctured into the arm for blood sample sampling operation.

The present invention provides a novel means usable for predicting a therapeutic effect of a combination therapy of an IL-6 inhibitor and a chemotherapy in a pancreatic cancer patient, said means being characterized by use of blood CD8-positive effector memory T cells as a biomarker. Specifically, in order to predict a therapeutic effect of a combination therapy of an IL-6 inhibitor and a chemotherapy in a pancreatic cancer patient, (i) the level of CD8-positive effector memory T cells that are contained in a blood sample which is collected from the pancreatic cancer patient is measured and (ii) when the level of the CD8-positive effector memory T cells is high, it is determined that the therapeutic effect yielded by the combination therapy is high.

The present invention provides a multi-arm Anti-CD40 antibody-mediated nanometer dual-drug delivery system and its preparation method and application, belonging to the field of biomedicine technology. In the present invention, chromium ion-doped zinc gallate nanocrystals are embedded in silica-coated gold nanorod nanoparticles GNR@MSNs to prepare composite nanoparticles cGNR@MSNs, and then multi-arm DOTV is modified on the surface of the nanoparticles, and then anti-CD40 antibodies are covalently coupled to obtain the multi-arm Anti-CD40 antibody-mediated nanometer dual-drug delivery system. The multi-arm Anti-CD40 antibody-mediated nanometer dual-drug delivery system improves diagnostic accuracy by combining multimodal imaging, promotes the development of imaging-guided combined therapy, exerts the synergistic effect of chemotherapy, immunotherapy and photothermal therapy, optimizes the tumor treatment effect, is suitable for the treatment of various malignant solid tumors, and has good practicality.

The invention discloses mouthwash for treating oral ulcer caused by chemoradiotherapy, which is mainly prepared from the following raw materials in percentage by weight: 0.15 percent to 0.25 percent of chlorhexidine gluconate, 0.015 percent to 0.025 percent of polypeptide of which the amino acid sequence is RWRWRW, 0.05 percent to 0.15 percent of sodium hyaluronate, 0.05 percent to 0.15 percent of menthol, 2.8 percent to 3.2 percent of humectant, 0.45 percent to 0.55 percent of sodium ascorbyl phosphate, 0.5 percent to 1 percent of sodium bicarbonate and the balance of distilled water. The mouthwash for treating the oral ulcer caused by the chemoradiotherapy not only has antibacterial and moisturizing functions, but also can relieve the pain degree of the oral ulcer caused by the chemoradiotherapy, reduce the infection risk and promote ulcer healing, the technical problem that an existing product is single in function is solved, a patient does not need to alternately use multiple preparations, and the compliance is high.

This disclosure relates to heterogeneous nuclear ribonucleic acid A2B1 (hnRNPA2B1) agonist compounds and their use in combination with chemotherapeutic agents for antitumor treatment. Specifically, this disclosure relates to fused ring compounds of formula (I), their cis-trans isomers, their enantiomers, their diastereomers, their racemic mixtures, their solvates, their hydrates, or their pharmaceutically acceptable salts or prodrugs thereof, compositions comprising any of the former, and products thereof, as well as the use of the aforementioned substances as hnRNPA2B1 agonists in the preparation of products for the prevention and / or treatment of tumors, said products may further comprise or be used in combination with chemotherapeutic agents. This disclosure has broad application prospects for the prevention and treatment of tumors.

One aspect of the invention provides a method of ovarian protection by administering to a female subject a composition comprising Mullerian inhibiting substance (MIS). Ovarian protection can be an induced arrest of folliculogenesis to preserve fertility. In some embodiments, ovarian protection is oncoprotection, the protection of the ovarian function during a cytotoxic treatment, e.g., chemotherapy. Another aspect of the invention relates to a method of treating PCOS, the method comprising administering to a female subject a composition comprising recombinant MIS protein.

This application relates to the technical field of traditional Chinese medicine compositions, specifically disclosing a traditional Chinese medicine composition for treating deficiency syndromes caused by illness, surgery, radiotherapy, and chemotherapy, and its preparation process. The composition comprises Ganoderma lucidum extract and ginseng powder. The preparation method of the Ganoderma lucidum extract is as follows: Step 1, pulverizing the raw material to obtain Ganoderma lucidum powder; Step 2, extraction: extracting the Ganoderma lucidum powder with a primary liquid-liquid phase solvent for 1.5-2.5 hours, adding non-oxidizing gas nano-bubble water and extracting for 0.5-1.5 hours, then adding acidic gas nano-bubble water and continuing extraction for 0.5-1.5 hours; Step 3, collection: collecting the extract, concentrating, forming a paste, and drying to obtain the Ganoderma lucidum extract; the primary liquid-liquid phase solvent includes an alcohol solution with a volume ratio of (2-5):1 and a non-polar organic solvent, with the alcohol volume percentage in the primary alcohol solution being 65-90%. The composition of this application has a higher content of Ganoderma lucidum polysaccharides and Ganoderma lucidum triterpenes.