54 results about "Magnetic hyperthermia" patented technology

This invention describes unique treatment methods and innovative articles that can be placed in a human or animal body to enable controlled destruction of diseased tissue. The methods include destruction of diseased cells and tissues by magnetically controlled motion and an externally controllable drug delivery process with a capability to start and stop the drug delivery at any time, for any duration. This invention provides two approaches to diseased cell destruction, (1) magneto-mechanical disturbance of cell structure (e.g. cancer cells) for cell lysis and (2) magnetically activated drug release at local regions (e.g. tumors) from a magnetic-particle-containing drug reservoir. The invention also provides combinations of both the above treatments for dual therapy. It further combines one or both of the treatments with magnetic hyperthermia for multifunctional cell destruction therapy. The approaches can be combined with magnetic MRI for monitoring the accuracy of placement as well as for following up the cancer destruction progress and appropriate reprogramming of the magneto-mechanical therapy and remote-controlled drug release.

Magnetic nanoparticle compositions are provided which provide an inherent temperature regulator for use in magnetic heating, particularly for use in magnetic hyperthermia medical treatments. The composition includes magnetic nanoparticles having a Curie temperature of between 40 and 46° C., preferably about 42° C., and may further include a polymeric material and optionally a drug or radiosensitizing agent. Methods of hyperthermia treatment of a patient in need thereof are provided which include the steps of administering to the patient a composition comprising magnetic nanoparticles having a Curie temperature of between 40 and 46° C.; and exposing the magnetic nanoparticles in the patient to an alternating magnetic field effective to generate hysteresis heat in the nanoparticles.

The present invention relates to a targeted magnetic nanoparticle drug and the preparation method thereof. The targeted magnetic nanoparticle drug comprises an effector molecule and a guidance molecule in a weight ratio of 1:0.0001-0.20. The aforesaid effector molecule is a magnetic particle, with a particle size of not more than 1000 nm and a specific adsorption rate (SAR) of 10-7000 W/gFe. The aforesaid guidance molecule comprises an antibody, a ligand or a magnetic particle. The particle size of the aforesaid targeted drug is 2-1000 nm. The targeted magnetic nanoparticle drug is prepared by coupling a magnetic particle and a guidance molecule in a weight ratio of 1:0.0001-0.20 in water, organic or inorganic substance or the mixed solution thereof. The resultant targeted magnetic nanoparticle drug can realize targeted magnetic hyperthermia treatment and targeted magnetic thermoablation treatment and prevention on the tumors, and effectively kill the cancer cells, and cure the malignant tumors.

The present invention relates to gold nanocages containing magnetic nanoparticles and a preparation method thereof. More specifically, relates to hollow-type gold nanocage particles, which contain iron oxide nanoparticles having a magnetic property and have an optical property of strongly absorbing or scattering light in the near-infrared (NIR) region, as well as a preparation method thereof. Due to their optical property and magnetic property, the magnetic nanoparticle-containing gold nanocages can be used in various applications, including analysis in a turbid medium with light, cancer therapy or biomolecular manipulation using light, contrast agents for magnetic resonance imaging, magnetic hyperthermia treatment and drug delivery guide, etc.

The invention discloses a novel high-performance vortex magnetic-domain iron-based nano magnetic hyperthermia medium and application of the medium in tumor magnetic hyperthermia. The unique vortex magnetic-domain iron-based nano magnetic hyperthermia medium comprises a core with vortex magnetic-domain iron-based nano particles, and the core is coated by an organic polymer with good biocompatibility or an inorganic material to form magnetic sol. The vortex magnetic-domain iron-based nano magnetic hyperthermia medium provided by the invention has a vortex magnetic state, high magnetic saturation intensity, good dispersion stability, high hysteresis heat loss, high heat production efficiency (specific absorption rate), for example the specific absorption rate of the vortex magnetic-domain Fe3O4 nano ring is 2000 watts/gram Fe-3000 watts/gram Fe, which is higher than magnetic heat production of Feridex in commercial use by one order of magnitude, so that cancer cells can be effectively killed. Moreover, the novel high-performance vortex magnetic-domain iron-based nano magnetic hyperthermia medium further has good biocompatibility, is safe and nontoxic and has wide application prospect in biomedicine.

The invention discloses a preparation method of a ferroferric oxide/ titanium dioxide magnetic biological activity coating. The preparation method comprises the steps of firstly, utilizing a solvent-thermal method, adopting ethylene glycol as a solvent, adopting 1,6-hexamethylenediamine, ferric trichloride hexahydrate and anhydrous sodium acetate as solutes, reacting in a reaction kettle, and obtaining water-soluble aminated ferroferric oxide magnetic nanoparticles after finishing reaction; secondly, adopting a microplasma oxidation method, adopting water as a solvent, adopting the water-soluble aminated ferroferric oxide magnetic nanoparticles, calcium salt, phosphor salt and weak acid as solutes, and forming an electrolyte solution; and adopting a titanium/ titanium alloy sample as an anode and stainless steel as a cathode, adopting a pulse power supply for carrying out microplasma oxidation treatment on the titanium/ titanium alloy sample, and after finishing reaction, generating the ferroferric oxide/ titanium dioxide magnetic biological activity coating on a surface layer of the titanium/ titanium alloy sample. The magnetic material can respond to an external magnetic field, a magnetocaloric effect is produced through the external alternating magnetic field so as to heat up a focus area, and tumor cells are killed, so that the function of bone cancer magnetic hyperthermia is realized.

The invention discloses a preparation method of a polyacrylic-acid modified water-soluble ferrite nano-cluster, belonging to the field of the preparation of nano-material. The water-soluble superparamagnetic MFe2O4 (M=Fe, Co, Ni, Cu, Mn and Zn) nano-cluster is obtained by adjusting the pH value of reaction solution by using the hydroxide and the acetate of alkali metals or alkaline earth metals and carrying out thermal treatment to the solvent of the system, wherein the FeCl3.6H2O, the CoCl2.6H2O and the like are used as precursors, and the polyacrylic acid with hydrophilic groups is used as a surfactant. The grain size of the nano-cluster can be adjusted in the range of 33.7-1909.8nm by changing the preparation parameters such as the reaction concentration, the reaction time, the reaction temperature and the like. The prepared MFe2O4 (M=Fe, Co, Ni, Cu, Mn and Zn) nano-cluster has stable dispersibility in aqueous solution and is easy to be enriched in the external magnetic field. The preparation method of the polyacrylic-acid modified water-soluble ferrite nano-cluster solves the problems of complex preparation process and high cost of the water-soluble magnetic nano-cluster and has wide application prospect in the filed of targeted medicament delivery and magnetic hyperthermia.

The invention provides a nano-drug carrier with a synergistic action of magnetic hyperthermia-chemotherapy. The nano-drug carrier is used for carrying nano-drug particles, and is characterized by comprising a mesoporous shell layer, a kernel and a deoxyribonucleic acid (DNA) molecular layer, wherein the mesoporous shell layer is formed by mesoporous silica particles; a plurality of mesoporous ducts are formed in the mesoporous shell layer; the mesoporous ducts form mesoporous at the surface of the mesoporous shell layer; the kernel is embedded in the internal part of the mesoporous shell layer and is formed by ferroferric oxide (Fe4O3) nano-particles; the DNA molecular layer is formed by DNA molecules encapsulated on the mesoporous; the mesoporous ducts penetrate the mesoporous shell layer for carrying the nano-drug particles; the mesoporous ducts are distributed in a radial pattern from the kernel to the mesoporous shell layer; the DNA molecules are nucleotide chains 20 to 40 in length. The invention also provides a nano-drug, carrying drugs, with the synergistic action of magnetic hyperthermia-chemotherapy. According to the nano-drug, the mesoporous ducts are encapsulated by using DNA molecules, so that the probability that anti-cancer drugs are leaked accidentally during a drug transportation process is reduced.

The invention discloses an application of using a protein-coated iron-based magnetic nano-particle as a magnetic hyperthermia medium. By taking the iron-based magnetic nano-particle as a core, the surface of the magnetic nano-particle core is coated with protein to form stable magnetic hydrosol. The magnetic hyperthermia medium has good biocompatibility, stable magnetic soil and high magnetic hyperthermia performance, can be used for effectively killing cancer cells, and has a wide application prospect in magnetic hyperthermia and hyperthermia chemotherapy as well as integrated anti-cancer diagnosis and treatment.

The invention discloses a drug-loaded liquid metal compound, and a preparation method and an application thereof, and belongs to the technical field of medicines. The preparation method comprises thefollowing steps: mixing liquid metal with a surfactant, stopping mixing when the liquid metal becomes liquid metal pellets, and removing the excess surfactant; and mixing a medicinal preparation or adrug-loaded micro-nano preparation with the liquid metal pellets to obtain the drug-loaded liquid metal compound. The liquid metal is a liquid at normal temperature, and has good injectability, excellent biocompatibility, excellent CT imaging function and good magnetocaloric effect. The in-situ multi-point injection of the drug-loaded liquid metal compound is performed under the guidance of CT imaging to make the compound uniformly distributed in the tumor site, the tumor undergoes uniform thermal stimulus under the action of a certain size of alternating magnetic field, and the vortex heat generating effect of the liquid metal makes the temperature of the tumor kept at 43-48 DEG C in order to achieve magnetic hyperthermia of the tumor; and heat can stimulate the sensitivity of tumor cellsto the drug, promote drug release and achieve chemotherapy and magnetic hyperthermia combined treatment of tumors.

The invention relates to a process for pre-concentration and detection of at least one single-stranded nucleic acid target molecule, the process comprising steps of generating a flow of liquid comprising at least one magnetic nanoparticle in a micro-channel and a plurality of single-stranded nucleic acid probe molecules attached to the nanoparticle, of generating an alternating magnetic field in the part of the micro-channel by means of the electromagnet, the magnetic field having an intensity and frequency that are suitable for causing magnetic hyperthermia of the nanoparticles so as to cause denaturing of the duplex formed by the single-stranded nucleic acid target molecule and the single-stranded nucleic acid probe molecule, and detection of the single-stranded target molecule dispersed in the liquid.

The invention relates to a magnet-therapy thermal-therapy massage assembly, and belongs to the technical field of the magnet-therapy thermal-therapy massage device structure. A magnet-therapy thermal-therapy assembly for massage is mounted in an assembly shell, and is characterized in that: a using surface of the assembly shell is a spherical convex massage head for massaging a body; the massage head is internally provided with respectively an infrared light source with an infrared therapeutic effect and a magnet with a magnetic therapeutic effect; and the infrared light source and the exterior of the magnet are respectively covered by a matching protective cover. The magnet-therapy thermal-therapy assembly for massage of the invention is reasonable in structure design and convenient and reliable in use, can be installed in any massage device so as to play the auxiliary massage effect, can also make the massage effect more obvious through the thermal therapy and magnet therapy in the massage process, and is highly practical.

The invention discloses a preparation method of a Fe3O4 nano-rod material capable of being used for magnetic hyperthermia agents. The method comprises: synthesizing a Fe3O4 magnetic material with a nano-rod shape by using FeCl3.6H2O as a raw material through a hydrothermal reaction and a high temperature annealing method. According to the present invention, the method has characteristics of simpleexperiment operation and few uncontrollable factors, and can perform large-scale preparation in a universal environment; and the Fe3O4 nano-rod material prepared by the method has good magnetocaloricproperty, and can meet the research and development of magnetic hyperthermia agents for tumor in medicine so as to increase the magnetic hyperthermia effect.

The invention belongs to the technical field of nano material production, and particularly relates to a preparation method of FeCoNiCu series high-entropy magnetic nano powder capable of being used for magnetic hyperthermia. According to the method, FeCl2. 4H2O, CoCl2. 6H2O, NiCl2. 6H2O and CuCl2. 2H2O are used as raw materials, and the FeCoNiCu series high-entropy magnetic nano powder with an fcc structure is synthesized through an ethylene glycol process. The preparation method has the beneficial effects that the operation is simple, the synthesis method is simple and convenient, the powder is fine and uniform, the crystallinity is high, and the magnetocaloric performance is excellent. The high-entropy magnetic nano powder prepared by the method can be used as a magnetic hyperthermia agent of tumor cells; when an alternating magnetic field with the strength of 46 Oe and the frequency of 266 kHz is applied, the specific loss power of the high-entropy magnetic nano powder under the magnetic fluid concentration of 2 mg/ml reaches up to 321 W/g; and the high-entropy magnetic nano powder is a cheap high-performance magnetic hyperthermia material and can be applied to the biomedical field such as tumor magnetic hyperthermia treatment.

The invention provides a spindle-shaped iron oxide nano material as well as a preparation method and application thereof, and belongs to the technical field of nano materials. According to the preparation method, a hydrothermal method is adopted, the spindle-shaped Fe2O3 nano material can be prepared by regulating and controlling the concentration of reactants and controlling the reaction temperature, and the spindle-shaped Fe2O3 nano material is controllable in size, regular in morphology and uniform in structure. The spindle-shaped Fe2O3 nano material prepared can achieve the material advantages of huge surface energy and the like, and has wide application prospects in the biomedical fields of bioanalysis and detection, electrochemical biosensors, cell and protein separation and recognition, magnetic resonance imaging, tumor magnetic hyperthermia, drug targeting and slow release, antibacterial effect and the like.

The invention discloses a composite prodrug nanocarrier for reversing tumor drug resistance and a preparation method thereof, and belongs to the field of polymer materials and medical engineering. Thecomposite prodrug nanocarrier is formed by self-assembly of an amphiphilic pH-sensitive macromolecular prodrug and a superparamagnetic nanoparticle, and has a typical core-shell structure, the core of the composite prodrug nanocarrier is formed by coating a drug-coupled hydrophobic segment of an amphiphilic pH-sensitive macromolecular prodrug with the superparamagnetic nanoparticle, and the shellis formed by a hydrophilic segment of an amphiphilic pH-sensitive macromolecular prodrug. Since the composite prodrug nanocarrier uses the conditional responsive amphiphilic macromolecular prodrugtoreplace a conditional responsive amphiphilic macromolecule, the composite nanocarrier simultaneously has both efficient magnetic hyperthermia and targeted chemotherapy interference-free from magnetocaloric action, the magnetic hyperthermia and chemotherapy can be more effectively combined and targeted to tumor tissues, and effective reversal of tumor drug resistance can be ultimately achieved.

The invention relates to an automatic positioning method for a critical heat production value of magnetic nanoparticles based on a simplex algorithm. After a simplex algorithm and a magnetic nanoparticle critical heat production technology are introduced, a finite element method is applied to solve the biological heat transfer mathematical model based on magnetic nanoparticle heat production, andthe magnetic nanoparticle critical heat production value is automatically positioned through algorithm optimization; on the basis, the application of the improved magnetic nanoparticle heat productiontheory effectively improves the prediction precision of the temperature distribution of the target geometric model. According to the invention, the optimal particle attribute of the magnetic nanoparticles during the magnetic hyperthermia period can be finally optimized so as to be applied to the magnetic nanometer hyperthermia instrument, and the magnetic hyperthermia effect of the magnetic nanometer hyperthermia instrument is improved.

The invention discloses targeted magnetic nanoparticles with heating, chemotherapy and imaging functions, and a preparation method and use thereof. The targeted magnetic nanoparticles are drug-loadedmagnetic nanoparticles obtained by reacting an OA-Pluronic-stabilized Fe3O4 sol with an Ara-C solution; wherein the volume ratio of the OA-Pluronic-stabilized Fe3O4 sol to the Ara-C solution is 5- 10ml: 250-5000[mu]L. The Fe3O4 at Ara-C nanoparticles are excellent magnetic induction agents, chemotherapeutic agents and MRI contrast agents, which provide conditions for magnetic hyperthermia, chemotherapy, magnetic targeting and imaging drug tracing in vivo.

The invention relates to a method for producing sub-micrometric particles, which comprises: mechanochemical treatment of homogeneous or heterogeneous magnetic materials until a mass which consists mostly of magnetic nanocrystal aggregates is obtained; selection of aggregates so that the nanocrystals have a Curie temperature within a predefined variation range; functionalization of the aggregates in order to obtain coating thereof with molecules of one or more of the following types of substances: substances for which the tumour cells have a particular metabolic avidity; substances having a biochemical affinity with the tumour cells; substances having an affinity with the acid microenvironment which surrounds the neoplastic cells. In addition to the method the following are claimed: the particles thus produced; their theranostic use which allows the in vivo execution, without interruption, of the diagnosis or monitoring step and the therapy step by means of magnetic hyperthermia of malignant neoplasms, including those localized in the so-called “sanctuary sites” such as the central nervous system and the testicle; an apparatus designed for this use.

The invention relates to a self-temperature-control magnetic nanowire and s preparation method thereof, and belongs to the technical field of tumor magnetic induction thermotherapy. In order to solvethe problems of low heat production rate and agglomeration of magnetic nanoparticles, the invention provides a preparation method of a self-temperature-control magnetic nanowire. The preparation method comprises the following steps: anodizing an aluminum foil to prepare an aluminum anodized micro-channel template, depositing zinc-cobalt-chromium ferrite hydroxide in the micro-channel template by using a chemical coprecipitation method, performing sintering to form a zinc-cobalt-chromium ferrite magnetic nanowire, and carrying out surface hydrophobization treatment on the magnetic nanowire. Theself-temperature-control magnetic nanowire prepared by the invention has the diameter of 5-45nm, the length of 5-30mu m and the Curie temperature point of 42-45 DEG C, is stable in chemical propertyand excellent in magnetic property, has the Curie point temperature meeting the magnetic hyperthermia requirement, has the advantages of high heat yield, low possibility of agglomeration, good performance consistency and good biocompatibility, and can be used for batch production of magnetic nano media and magnetic hot seeds for magnetic hyperthermia.

The invention relates to the technical field of a medical bone material, in particular to magnetic calcium phosphate-based bone cement and a preparation method thereof. The magnetic calcium phosphate-based bone cement is prepared from a solid phase mixed material and a liquid phase through mixing according to a solid-liquid ratio of 2.9 to 3.3g/mL; the solid phase mixed material is prepared from beta-tertiary calcium phosphate, calcium biphosphate and magnetic composite powder according to the mass ratio of (1.3 to 1.6):1:(0.2 to 0.3); the magnetic composite powder is a compound mainly prepared from ferroferric oxide, zinc oxide and carbon nanometer tubes. The liquid phase is citric acid solution added with glutin; the concentration of the citric acid solution is 0.2 to 0.4mol/L. The egg white pore-forming porous ferroferric oxide nanometer balls are used; the biocompatibility is improved; zinc oxide and carbon nanometer tubes coat the outside of the ferroferric oxide; on one hand, thefibrocyte multiplication, the bone growth and the bone mineralization can be promoted; on the other hand, a higher magnetic saturation value is realized; necessary conditions are provided for magnetic hyperthermia effect.