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Preparation method of FeCoNiCu series high-entropy magnetic nanopowder capable of being used for magnetic hyperthermia

A magnetic nano and magnetic hyperthermia technology, which is applied in the field of biomedical application of nanomaterials, can solve the problem that the heat production performance of the magnetic thermotherapy agent has not been well improved, and achieve a large market application potential, enhanced heat production capacity, The effect of easy operation of the experiment

Active Publication Date: 2021-08-31
UNIV OF SCI & TECH BEIJING
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Aiming at the practical problems existing in the prior art that the heat production performance of the magnetic thermotherapy agent has not been well improved, the purpose of the present invention is to provide a simple preparation process, rapid heat production in an alternating magnetic field and good biocompatibility. Medical magnetic hyperthermia high-entropy magnetic nanopowder and preparation method thereof

Method used

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  • Preparation method of FeCoNiCu series high-entropy magnetic nanopowder capable of being used for magnetic hyperthermia
  • Preparation method of FeCoNiCu series high-entropy magnetic nanopowder capable of being used for magnetic hyperthermia
  • Preparation method of FeCoNiCu series high-entropy magnetic nanopowder capable of being used for magnetic hyperthermia

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preparation example Construction

[0033] The concrete of described preparation method comprises the following steps:

[0034] S1) The chloride salt raw material of Fe, Co, Ni, Cu is changed from the nominal composition Fe of alloy powder a co b Ni c Cu d Weighed after conversion into mass according to atomic percentage,

[0035] S2) The polyol solution is divided into polyol solution I and polyol solution II, and the alkaline solid particles and polyol solution I are placed in container A according to a certain ratio to obtain alkaline solid particles-polyol solution;

[0036] Put polyol solution II in container B, mix the raw materials weighed in S1) and add them to container B, put them into a magnetic rotor, stir evenly, and obtain a mixed solution,

[0037] S3) heating the mixed solution obtained, and magnetic stirring at the same time, when heated to a certain temperature, adding the alkaline solid particle-polyol solution into the mixed solution for reaction, turning off the heater after the mixed so...

Embodiment 1

[0048] Embodiment 1: with Fe 30 co 30 Ni 30 Cu 10 As a nominal component of the high-entropy magnetic nanopowder, the metal salt (FeCl 2 4H 2 O, CoCl 2 ·6H 2 O, NiCl 2 ·6H 2 O, CuCl 2 2H 2 O) according to the atomic percentage conversion into mass weighing, take 4g granular KOH and measure 20mL of 99.8% propylene glycol solution in a beaker, then measure a portion of 99.8% propylene glycol solution 30mL in another beaker , and add the metal salt, put into the magnetic stirring rotor. Then the propylene glycol solution and the KOH-propylene glycol solution that are dissolved with the metal salt are all placed in a magnetic stirring heater for heating, and when the temperature rises to 170° C., the propylene glycol solution that is dissolved with the metal salt is mixed with the KOH-propylene glycol solution that is filled, After 3 minutes of reaction, the heating was stopped, and the mixture was cooled to obtain a gel-like mixture. The colloidal mixture was washed t...

Embodiment 2

[0050] Embodiment 2: with Fe 40 co 25 Ni 25 Cu 10 As a nominal component of the high-entropy magnetic nanopowder, the metal salt (FeCl 2 4H 2 O, CoCl 2 ·6H 2 O, NiCl 2 ·6H 2 O, CuCl 2 2H 2 O) according to the atomic percentage conversion into mass weighing, take 4g granular KOH and measure 20mL of 99.8% propylene glycol solution in a beaker, then measure a portion of 99.8% propylene glycol solution 30mL in another beaker , and add the metal salt, put into the magnetic stirring rotor. Then both the ethylene glycol solution in which the metal salt is dissolved and the KOH-ethylene glycol solution are placed in a magnetic stirring heater for heating. The diol solutions were mixed with each other, and the heating was stopped after reacting for 3 minutes, and cooled to obtain a gel-like mixture. The colloidal mixture was washed three times with deionized water and absolute ethanol respectively, and a black precipitate was obtained after centrifugation at 10000 rpm for 5...

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Abstract

The invention belongs to the technical field of nano material production, and particularly relates to a preparation method of FeCoNiCu series high-entropy magnetic nano powder capable of being used for magnetic hyperthermia. According to the method, FeCl2. 4H2O, CoCl2. 6H2O, NiCl2. 6H2O and CuCl2. 2H2O are used as raw materials, and the FeCoNiCu series high-entropy magnetic nano powder with an fcc structure is synthesized through an ethylene glycol process. The preparation method has the beneficial effects that the operation is simple, the synthesis method is simple and convenient, the powder is fine and uniform, the crystallinity is high, and the magnetocaloric performance is excellent. The high-entropy magnetic nano powder prepared by the method can be used as a magnetic hyperthermia agent of tumor cells; when an alternating magnetic field with the strength of 46 Oe and the frequency of 266 kHz is applied, the specific loss power of the high-entropy magnetic nano powder under the magnetic fluid concentration of 2 mg / ml reaches up to 321 W / g; and the high-entropy magnetic nano powder is a cheap high-performance magnetic hyperthermia material and can be applied to the biomedical field such as tumor magnetic hyperthermia treatment.

Description

technical field [0001] The invention belongs to the biomedical application field of nanometer materials, and in particular relates to a preparation method of FeCoNiCu system high-entropy magnetic nanopowder which can be used for magnetic hyperthermia. Background technique [0002] Malignant tumors seriously threaten human health and life, and are one of the most important causes of human death. According to the latest estimates from the International Agency for Research on Cancer (IARC), there will be more than 19 million new cancer cases worldwide in 2020. The treatment of cancer is still one of the major challenges in modern medicine. At present, the clinical treatment methods for malignant tumors mainly include surgery, drug chemotherapy and radiotherapy, but these treatments have disadvantages such as large toxic side effects, high recurrence rate, and poor specificity. With the rapid development of science and technology, tumor thermotherapy has attracted great attenti...

Claims

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Application Information

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IPC IPC(8): B22F9/24A61K41/00A61P35/00B82Y5/00
CPCB22F9/24A61K41/0052A61P35/00B82Y5/00B22F2202/05B22F2304/054
Inventor 刘雄军梁定亮王辉吴渊蒋虽合吕昭平
Owner UNIV OF SCI & TECH BEIJING
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