991 results about "Mass" patented technology

The invention discloses a standard volume-based mass spectrum signal calibration system and method, and belongs to the field of measurement, the standard volume-based mass spectrum signal calibration system comprises a standard flow generation system and a mass spectrum detection system.The standard flow generation system comprises a standard tank, a first valve, a fifth valve and a micro-leakage valve which are sequentially connected through a gas pipeline; a gas inlet pipeline, a film gauge and a first molecular pump set are connected to a gas pipeline connecting the first valve and the fifth valve in parallel, a second valve is installed on the gas inlet pipeline, and a fourth valve is installed at an inlet of the first molecular pump set. The mass spectrometry detection system comprises a vacuum chamber communicated with the micro-leakage valve through a gas pipeline, a mass spectrometer, a second molecular pump set and a full-scale gauge are connected to the vacuum chamber, and a gate valve is installed at an inlet of the second molecular pump set. The gas release rate can be calculated and continuously adjusted on the premise that a leak hole is not needed, and the problems that in the prior art, a standard leak hole is limited in application range, low-flux measurement is inaccurate, the nominal leak rate is prone to drifting, and cost is high are solved.

The invention belongs to the technical field of aircraft oil leakage monitoring, and relates to an aircraft oil leakage detection method based on a high-sensitivity mass spectrometry technology, and the method comprises the steps: obtaining a time-resolved mass spectrogram of aviation kerosene molecules in a sample testing stage, and storing the time-resolved mass spectrogram in a database; then oil gas molecules are captured at leakage-prone points of an aircraft pipeline system through a gas collection probe, the captured oil gas molecules are transmitted to an ion source end of a proton transfer reaction mass spectrometer through a negative pressure transmission system to be ionized to generate ions, and the ions are analyzed by a mass analysis system to obtain a mass spectrum; comparing the mass spectrogram obtained by analysis with a time-resolved mass spectrogram in a database, and judging whether leakage occurs or not; based on the method, the problems of insufficient anti-interference capability, difficulty in sample collection and the like of a high-sensitivity mass spectrum oil gas leak detection method can be solved in a targeted manner, and the functions of environmental interference suppression, efficient collection of oil gas molecules, improvement of spatial scanning resolution and the like can be realized at the same time.

Methods for identifying a chemical structure of a compound based on mass spectrometry (MS) data using one or more computing devices are disclosed. The methods include receiving mass spectrometry (MS) data that includes a plurality of mass-to-charge values associated with fragments obtained from mass spectrometry performed on the compound, inputting the plurality of mass-to-charge values into a tokenizer trained to generate a plurality of tokens based on the plurality of mass-to-charge values, and determining one or more chemical structures of the compound based at least in part on the plurality of tokens.

The invention discloses a mass spectrometer electrometer based on a capacitance integrator, and belongs to the technical field of electrometers. Comprising a capacitance integrator, the capacitance integrator is connected with a voltage holding circuit, the voltage holding circuit is connected with an acquisition control circuit and an amplification circuit, and the amplification circuit is connected with the acquisition control circuit; and the acquisition control circuit controls electric signals input into the capacitance integrator, the voltage holding circuit and the amplifying circuit through an I / V conversion control method, so that I / V conversion is completed. The capacitance integration is used for completing I / V conversion, the problem of high-resistance forbidding can be solved, meanwhile, compared with high-resistance conversion, the capacitance integration is adopted, the temperature stability of the electrometer is improved, and noise is reduced.

The invention relates to the technical field of vacuum measurement, in particular to a device for expanding the linear range of mass spectrometry measurement, which comprises a gas transmission pipeline, an electromagnetic valve, a small hole and a mass spectrometer, and is characterized in that the front end of the gas transmission pipeline is used for allowing a sample to be measured to enter, and the rear end of the gas transmission pipeline is connected with the mass spectrometer; the middle part of the gas transmission pipeline is divided into three channels, namely a first gas transmission pipeline, a second gas transmission pipeline and a third gas transmission pipeline; the first electromagnetic valve and the first small hole are sequentially arranged on the first gas transmission pipeline, the second electromagnetic valve and the second small hole are sequentially arranged on the second gas transmission pipeline, and the third electromagnetic valve and the third small hole are sequentially arranged on the third gas transmission pipeline. According to the method, manual dilution or segmented sample injection is not needed, a wide concentration range can be covered by single analysis, more than 60% of time cost is saved, and measurement in a dynamic range of 106 is realized.

The invention relates to a detection method for determining isotope abundance of a 15N or 18O labeled nitrate sample by using an organic mass spectrum. The detection method comprises the following steps: (1) dissolving the 15N or 18O labeled nitrate sample in a methanol aqueous solution; (2) taking the supernatant, filtering with a filter membrane, and diluting with a methanol aqueous solution to obtain a solution to be detected; and (3) detecting the solution to be detected by using a high-resolution liquid chromatograph-mass spectrometer, selecting a mass spectrum in a peak appearance time window, recording relative mass spectrum signal intensities with mass-to-charge ratios of 61.988 and 62.985, and calculating to obtain the 15N isotope abundance. Or recording the relative mass spectrum signal intensities with the mass-to-charge ratios of 61.988, 63.993, 65.997 and 68.001, and calculating to obtain the abundance of the < 18 > O isotope. Compared with the prior art, the method has the advantages that the sample pretreatment time is greatly shortened, the economic cost is low, and the test result is accurate.

A method of mass spectrometry comprising: a) providing a mass spectrometer having a time of flight (TOP) mass analyser: b) performing a survey scan comprising separating a packet of precursor ion species and mass analysing ions so as to obtain first mass spectral data: c) determining a time window over which one of the precursor ion species. or fragment or product ions derived therefrom, were mass analysed: d) separating another packet of precursor ion species and mass analysing ions so as to obtain second mass spectral data. wherein the pusher of the TOP mass analyser is pulsed according to a plurality of consecutive pulse sequences during a plurality of respective pulse sequence time periods. wherein each pulse sequence consists of consecutive pushes that are arranged such that the duration between any pair of pushes in the pulse sequence is different to the duration between any other pair of pushes within the pulse sequence: f) selecting mass spectral data, from the second mass spectral data, that was obtained during a time period corresponding to said time window of the survey scan, so as to obtain selected data; g) repeating steps d) to f) at least one further time such that multiple sets of said selected data are obtained; combining said multiple sets of selected data and decoding the combined data to obtain mass spectral data representative of the mass to charge ratios of the ions detected by the TOP mass analyser.

The invention provides a mass spectrometer operation state monitoring method, system and device and a medium, and relates to the technical field of fault monitoring, and the method comprises the steps: collecting environment parameters in a mass spectrometer operation environment, carrying out the vacuum degree influence analysis of a mass spectrometer according to the environment parameters, and obtaining vacuum degree influence parameters; analyzing the mass axis offset influence of the mass spectrometer according to the environmental parameters to obtain mass axis offset parameters; testing to obtain an actual vacuum degree influence parameter and an actual mass error parameter of the mass spectrometer, performing state influence verification by combining the vacuum degree influence parameter and the mass axis offset parameter, and processing to obtain a vacuum verification coefficient and a mass verification coefficient; and according to the vacuum verification coefficient and the quality verification coefficient, performing fusion state anomaly analysis on the vacuum degree influence parameter and the quality axis offset parameter to obtain a state anomaly coefficient, and performing fault judgment and early warning. The technical problem that fault early warning is not timely in the monitoring process of the operation state of the mass spectrometer in the prior art is solved.

Known mass spectral data of a library of spectra corresponding to known compounds or known mass spectral data determined from a database of known compounds are compressed using a neural network encoder, producing a group of corresponding compressed known representations of known mass spectral data. Experimental mass spectral data of an experimental mass spectrum is compressed using the neural network encoder, producing a compressed experimental representation of the experimental mass spectral data. The experimental representation is compared to the group of known representations and each comparison is scored. At least one comparison with a score above a predetermined score threshold is selected. A known compound is determined from the selected at least one comparison. The known compound is identified as a compound of the experimental spectrum.

The invention relates to the technical field of mass spectrometers, and discloses a mass spectrometer tuning method and device, electronic equipment, a storage medium and a program product, and the method comprises the steps: obtaining a tuning parameter data set of a target mass spectrometer, the tuning parameter data set comprising a plurality of tuning parameters and a parameter range corresponding to each tuning parameter; obtaining an optimization target of the target mass spectrometer; based on the tuning parameter data set, the optimization target and a pre-constructed constrained multi-target Bayesian optimization framework, predicting an optimal tuning parameter combination of the optimization target, the optimal tuning parameter combination being used for tuning the target mass spectrometer; the constrained multi-objective Bayesian optimization framework combines Bayesian optimization and multi-objective optimization. According to the invention, multi-objective optimization is carried out based on the constrained multi-objective Bayesian optimization framework, the optimal tuning parameter combination can be automatically generated, simultaneous tuning of multiple parameters of the mass spectrometer is realized, and the tuning performance and precision of the mass spectrometer are improved.

The invention discloses an ultratrace mercury isotope analysis method, and relates to the technical field of environmental analysis. The method comprises the following steps: purging a liquid sample to be detected by nitrogen in a stannous chloride atmosphere, and trapping and concentrating mercury into a gold trapping tube; pyrolyzing the pyrolytic gold trapping tube to release mercury vapor; pyrolytic mercury vapor and thallium isotope internal standard aerosol are mixed to serve as a sample injection sample, and the sample injection sample is introduced into a multi-receiver inductively coupled plasma mass spectrometry; acquiring a mercury instantaneous signal and a thallium isotope signal; and calculating the mercury isotope ratio by adopting least square linear regression fitting in combination with a thallium internal standard ratio correction algorithm. According to the method, the instantaneous mercury isotope signal is generated by online combination of gold trapping and multi-receiver inductively coupled plasma mass spectrometry, the instantaneous signal is strategically collected and processed, the determination concentration of isotope analysis can be greatly reduced, the sensitivity of the method is remarkably improved, and direct determination of mercury isotope composition in a water sample with the concentration of 10 ng L <-1 > is met.

The invention provides a mass flow meter control method and system, a storage medium and electronic equipment, and relates to the technical field of flow monitoring. According to the technical scheme provided by the invention, the relation comparison table of the environment information and the fluid state information is established by collecting the historical data of the first multiple measurement nodes in the pipeline, and the target gas-liquid proportion is calculated by combining the current environment information and the fluid state information; and then matching the calculated target gas-liquid proportion with a preset gas-liquid proportion interval, selecting a corresponding correction weight, and establishing a corresponding relationship between gas-liquid proportion change and measurement correction. And finally, the correction weight is applied to the adjustment of the initial mass flow data, the influence of the gas-liquid proportion change on the measurement result is effectively compensated by establishing a complete data association and correction mechanism, the limitation of a single working condition calibration or simple compensation mode in the related technology is overcome, the mass flow of the fluid can be accurately measured, and the measurement accuracy is improved. And the measurement precision of the mass flow meter under a complex working condition is obviously improved.

The invention relates to the technical field of plasma concentration monitoring methods, in particular to a method for rapidly detecting the content of tacrolimus in plasma through paper spray mass spectrometry. The method provided by the invention comprises the following steps: adding a to-be-detected plasma sample into a precipitation solution, vortex, taking supernate, and dropwise adding the supernate onto a paper base; spraying voltage is applied to the paper base, the paper base generates electrospray, and the electrospray enters a mass spectrometer for detection; preparing a gradient matrix matched tacrolimus standard solution, replacing the to-be-detected plasma sample with the gradient matrix matched tacrolimus standard solution, repeating the operation, recording a detection result, and drawing a standard curve by taking the matrix matched tacrolimus concentration as an abscissa and taking peak area data acquired by a mass spectrometer as an ordinate; and comparing the recorded detection result with the drawn standard curve, and quantitatively analyzing the content of tacrolimus in the to-be-detected plasma sample. The method disclosed by the invention is simple to operate and high in analysis speed, has relatively good precision and accuracy and also has high sensitivity and high selectivity.

Disclosed is a method and device for the mass spectrometric quantification of two or more known target ion species, in which a mass spectrometric signal, composed of signal components of the two or more target ion species, which are not mass resolved in the mass spectrum, is weighted with quantification functions and summed, and a quantification parameter is determined for the two or more target ion species from the weighted sums.

The invention relates to the technical field of ion characterization and preparation, in particular to a high-throughput preparation mass spectrum device and method giving consideration to high-resolution characterization. The device comprises an ion source, an ion transmission cavity, a quadrupole mass screening cavity, an ion dissociation cavity, an ion deflection cavity, an ion deceleration and deposition cavity and a high-resolution mass spectrum characterization cavity which are sequentially arranged, wherein the high-resolution mass spectrum characterization cavity is formed in one side of the ion deflection cavity in the vertical direction; soft ionization is combined with a quadrupole analyzer to screen ions, the ions are dissociated through a dissociation cavity, an ion deflection cavity is used for selecting a high-resolution characterization or high-throughput preparation function, a high-resolution mass spectrum characterization cavity is used for achieving high-resolution characterization of screened and fragmented ions, and an ion deceleration and deposition cavity is used for high-throughput preparation of the ions. According to the method, perfect compatibility of high-throughput preparation and high-resolution mass spectrum characterization is realized through ion deflection design, and the method has a wide application prospect in the fields of efficient preparation of biological macromolecules, synthetic macromolecules and the like and the like.

Methods and systems are disclosed for predictive classification of a raw mass spectrum of a sample, the spectrum resulting from mass spectrometry analysis. The predictive classification is performed by a trained large-scale spectral model, including a self-supervised large-scale base spectral model trained with unidentified sample spectra from a plurality of sources and fine-tuned with a task-specific model trained with identified spectra.

The invention discloses a method for determining the content of trace holmium, thulium and tungsten in rare earth erbium and a compound thereof, which comprises the following steps: placing a rare earth erbium and compound sample thereof in a beaker, and performing a blank test along with a sample; adding nitric acid, heating at low temperature until the sample is completely dissolved, and cooling; transferring into a volumetric flask, adding a cesium internal standard solution, diluting with water, and uniformly mixing; the holmium, the thulium and the tungsten are measured by using an oxygen mode of an inductively coupled plasma tandem mass spectrometer, and the contents of the holmium, the thulium and the tungsten are calculated according to a working curve method. According to the method, the inductively coupled plasma tandem mass spectrometry technology is used, and mass spectrum interference of an erbium matrix on holmium, thulium and tungsten is effectively eliminated by selecting a proper reaction mode and optimizing the flow of reaction gas.

The invention relates to the technical field of analytical chemistry and information processing, in particular to a weighted characteristic peak quality accuracy-based forward and reverse mass spectrogram similarity matching method, which is suitable for high-throughput screening of risk substances in food safety detection, and comprises the following steps: acquiring mass spectrogram data to be queried and standard mass spectrogram data in a database; fragment ions with the peak intensity ranked in the first 7 or larger than or equal to 10 in the mass spectrum to be inquired and the standard mass spectrum are selected; judging whether the m / z difference value of fragment ions in the mass spectrum to be queried and the standard mass spectrum is less than or equal to 5ppm or not; calculating a forward matching degree score of the to-be-queried mass spectrum and the standard mass spectrum, and a reverse matching degree score of the standard mass spectrum and the to-be-queried mass spectrum; calculating a mean value according to the forward matching degree score and the reverse matching degree score; the average value is output as the similarity score of the mass spectrum to be queried and the standard mass spectrum, and the possibility that the screening result shows false negative is greatly reduced by considering the quality accuracy of fragment ions.

Mass spectrometry includes: identifying sets of charge state distributions (CSDs) in deconvolved mass spectrometry data, where the CSDs of each set include at least one common mass spectrometry peak assigned a respective different charge state in each CSD of each set; distributing a respective weighting factor for each CSD in each group; calculating a fractional weighted average molecular weight of each compound CSD using a weighting factor in each group; finding out a single target CSD closest to the calculated average molecular weight in each group; for each common wave crest of each determined group, the sum of the intensities of the mass spectrum wave crests which are respectively and commonly distributed in the group is calculated, and the sum intensities are distributed to the single target CSDs of the group; all CSDs except the target CSD are removed; the sum intensity is used to calculate the abundance of each component compound.

One mode of a chromatograph mass spectrometer according to the present invention includes: a measurement unit (1) that includes a chromatograph unit (1A) and a mass spectrometry unit (1B) capable of performing MS / MS analysis, and collects chromatograph mass spectrometry data having three dimensions of time, m / z, and a signal intensity by repeatedly performing the MS / MS analysis by data independent analysis in the mass spectrometry unit on a sample containing a compound separated by the chromatograph unit; a component detection unit (42) that detects a compound and a component corresponding to a partial structure of the compound by obtaining MS / MS spectra of a bar graph presentation based on chromatograph mass spectrometry data over a predetermined m / z range for a target sample, estimating precursor ion peaks in each of the MS / MS spectra, and selecting peaks based on a predetermined standard regarding an m / z direction in each of the MS / MS spectra and a predetermined standard regarding a time direction for peaks that can be considered to be identical or an identical group on the MS / MS spectra; a narrowing unit (43, 44) that narrows down components to be analyzed by performing screening using prior information on the detected component; and a composition estimation unit (45) that, by using m / z information corresponding to a narrowed down component, estimate a composition or a chemical formula of the component.

In a mass spectrometer (10) for gas analysis, comprising: a mass spectrometer housing (12) evacuated by a vacuum pump; an ion source (16) for ionizing gas atoms or molecules entering the mass spectrometer enclosure (12) and accelerating ions in the mass spectrometer enclosure (12); an ion trap (22) made of an electrically conductive material for collecting ions generated by the ion source (16); an electrical measurement device (24) for measuring the potential or current of the ion trap (22) and connected to the ion trap (22) for inferring the ions collected by the ion trap (22) from the measured potential or current; a magnetic or electromagnetic deflection device configured to deflect or map ions having a specific mass-to-charge ratio to the ion trap (22); an electron barrier (30) made of an electrically conductive material is provided at the ion trap (22), the electron barrier having a lower potential than the ion trap (22) and being configured to generate a reverse electric field to return electrons released from the ion trap (22) onto the ion trap (22).

Method and system of mass spectrometry is provided. The method comprises performing a first and a second MS1 scans on precursor ions produced by ionising a sample. The first MS1 scan comprises mass analysing a first set of the precursor ions transported to a mass analyser using an ion transport device operated at a first setting. The second MS1 scan comprises mass analysing a second set of the precursor ions transported to a mass analyser using the ion transport device operated at a second setting. Energies imparted on the precursor ions by the ion transport device are different in the first and second settings. Based on intensities of mass spectral peaks of the first and second MS1 scans, a mass spectral peak in at least one of the first MS1 scan or the second MS1 scan indicative of a precursor ion mass spectral peak is determined.

And re-sampling triggered by uncertain results in mass spectrum screening. The invention provides a system / technical scheme for promoting repeated sample injection triggered by uncertain results in mass spectrum screening. In various embodiments, the system may access a screening list specifying a plurality of target compounds. In aspects, the system can classify a plurality of target compounds as present or absent in a sample, respectively, based on causing a chromatograph and a mass spectrometer to perform an iterative injection scheme on the sample, with subsequent iterations of the iterative injection scheme having progressive compound selectivity, and is triggered by the uncertain presence or absence of the classification result in the previous iteration.

The invention discloses an ocean deepwater weakly cemented sandstone saturated water nuclear magnetic T2 spectrum correction method, which comprises the following steps: 1, making a standard rock sample, and drying the rock sample until the quality is kept stable; 2, saturating the dried rock sample to a completely saturated state by using a turbid liquid, and carrying out nuclear magnetic T2 spectrum measurement to obtain a nuclear magnetic T2 spectrum of the weakly cemented rock sample under the condition that pores contain tiny solid impurities; 3, after displacing and drying the rock sample in the previous step, carrying out saturated water treatment by utilizing pure water, and then carrying out nuclear magnetic T2 spectrum measurement to obtain a nuclear magnetic T2 spectrum of the rock sample in a state that the pores contain the pure water; 4, constructing the nuclear magnetic T2 spectrums in the two states into a data set, and inputting the data set into a deep neural network model for training; and 5, correcting the nuclear magnetic T2 spectrum under the condition that the pores contain the tiny solid impurities by using the trained deep neural network model. According to the method, the nuclear magnetic T2 spectrum is corrected by using the deep neural network model, and the problem of signal attenuation distortion caused by impurity interference is effectively solved.

The invention discloses a card type DSL generation method for mass spectrum metadata standardization, and relates to the field of mass spectrum data analysis, and the card type DSL generation method comprises the following steps: constructing an initial mass spectrum metadata card type DSL model based on a mass spectrum experiment process and a standard term; analyzing causal association between the historical mass spectrum data set and fields in the initial mass spectrum metadata card type DSL model by adopting a causal discovery algorithm, generating a field diagnosis report, and generating a core version mass spectrum metadata card type DSL model based on the field diagnosis report; compiling the core version mass spectrum metadata card type DSL model through a DSL compiler to generate a data checker, a user data entry form and a data access API interface; and integrating a metadata quality score deployment engine in the user data entry form. Integrity verification of submitted data is completed through the data verifier, compliance data is stored in the target database through the data access API interface, and the technical problems of field redundancy, low input efficiency and difficult quality control in the mass spectrum metadata standardization process are solved.

The invention discloses a flight time mass spectrum electric field structure design parameter optimization method. According to the method, the rapid convergence capability of a particle swarm optimization algorithm and the global jump capability of a simulated annealing algorithm are fused, and the global search capability and stability of optimization in a high-dimensional parameter space are remarkably improved by introducing a dynamic disturbance mechanism and a temperature control function. The method is particularly suitable for parameter optimization of electric field structures such as a reflector region and a multi-section acceleration region in a reflective TOF mass spectrometer, and aims at maximizing mass spectrum resolution or minimizing flight time broadening.

The invention relates to the technical field of ore recognition, in particular to a method and a system for quickly and preliminarily recognizing field ore quality of coal-series trilean metal mineral products, which comprises the following steps of: acquiring ore samples and acquiring main peaks, structures and infrared images, extracting image features to generate mutation numbers, analyzing sampling coordinates to reconstruct a connection structure, and calculating the quality of the coal-series trilean metal mineral products. Drawing a closed boundary to judge coordinate attribution, and outputting an ore quality identification scheme. According to the method, main peak reflection, microscopic image layers and infrared spectrum acquisition results are numbered in a unified manner and are subjected to time sequence binding, a synchronous corresponding relation among multi-source images is established, continuous change nodes and sudden change areas are identified in combination with offset tracks and structural features, spatial concentration blocks are generated by using number and coordinate mapping, and a connected structure is reconstructed; and drawing a closed boundary according to the track to form a region classification basis, verifying a mass change direction through image sequence coherence, and outputting a tagging identification result, thereby realizing rapid positioning and accurate classification of the field ore sample.

A mass spectrometry system that includes first and second ion sources that produce ions, the ions produced by the second ion source being calibration ions to calibrate the mass spectrometry system; an ion transfer device that receives the ions as a continuous stream during a first time period and forms a first ion packet as a single ion packet, such that during a second time period when the ion transfer device delivers the first ion packet, it receives the ions as a continuous stream to form a second ion packet by accumulating the incoming ions in another single ion packet, such that the ion transfer device separately delivers the formed ion packets at a frequency in a range from 1 to 1000 Hz; and a mass analyzer that separates the ions in the ion packets based on the mass-to-charge ratio of the ions.

The invention relates to the technical field of novel material chemical analysis, and discloses a triphenyl phosphate purity standard substance valuing method, which comprises the following steps: filtering, drying, dissolving and sterilizing a triphenyl phosphate sample; a triphenyl phosphate sample is comprehensively analyzed from different angles by comprehensively applying a GC-MS (Gas Chromatography-Mass Spectrometry) technology, an NMR (Nuclear Magnetic Resonance) technology, an infrared spectroscopy, a gas chromatography-flame ionization detector method, a Karl Fischer method and an inductively coupled plasma mass spectrometry, and finally, the purity value of the triphenyl phosphate purity standard substance is calculated by a mass balance method. The method provides a scientific and accurate technical means for quality control and standard formulation of the triphenyl phosphate product, has important practical application value for related industries in the fields of chemical engineering and material science, and is beneficial for improving the product quality and promoting industrial upgrading.

The invention discloses a method for measuring the content of impurity elements in high-purity quartz by ICP-MS (Inductively Coupled Plasma Mass Spectrometry). The method is characterized by comprising the following steps: S1, drying a sample; s2, weighing a sample; s3, primary dissolution with strong acid I; s4, secondary dissolution with strong acid II; s5, cooling and constant volume; and S6, respectively testing and analyzing the standard series working solution, the sample solution and the blank solution on ICP-MS (Inductively Coupled Plasma Mass Spectrometry). According to the method, the influence of impurity elements brought in in the sample treatment process on the determination result is reduced, the harm of precipitation generated by some metal ions and chloride ions on the accuracy of the result is avoided, the inductively coupled plasma mass spectrometer is adopted for analysis in the later period, the detection limit is greatly reduced, and the accuracy of the result is improved. Therefore, the purposes of reducing the lower limit of impurity element content measurement and increasing the upper limit of the silicon dioxide content range (the applicable silicon dioxide content range of the method can be higher than 99.99%) are achieved.