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Tandem time of flight mass spectrometer and method of use

A time-of-flight mass spectrometry and time-of-flight technology, applied in the field of mass spectrometry, can solve the problems of time-consuming and monotonous, and achieve the effect of high acquisition speed and sensitivity

Inactive Publication Date: 2005-10-26
力可公司
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  • Claims
  • Application Information

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Problems solved by technology

The process is tedious and time-consuming, while ions from the ion source are discarded

Method used

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  • Tandem time of flight mass spectrometer and method of use
  • Tandem time of flight mass spectrometer and method of use
  • Tandem time of flight mass spectrometer and method of use

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Embodiment Construction

[0045] The serial mass spectrometry analysis method of the present invention comprises the following steps:

[0046] 1. Generate an ion pulse in the ion source, the ion pulse contains a mixture of different analytical ions;

[0047] 2. Separation of resolving ions in real time in a first time-of-flight mass spectrometer operating at low energy, thereby producing a string of ion packets in sequence of their masses;

[0048] 3. Sequentially split the analytical ions without mixing the separated ion packets;

[0049] 4. Rapid mass analysis of the fragment ions within the second time-of-flight mass spectrometer at a time scale much shorter than that of the first separation step;

[0050] 5. Under a single ion pulse from the ion source, obtain fragment mass spectra for multiple analytical ion mass-to-charge ratios;

[0051] 6. Optionally summing the fragment spectra of each resolved ion over multiple source pulses;

[0052] 7. The key to this method is that, for the same mass-to...

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Abstract

To provide comprehensive (i.e. rapid and sensitive) MS-MS analysis, the inventor employs a time-nested separation, using two time-of-flight (TOF) mass spectrometers. Parent ions are separated in a slow and long TOF1, operating at low ion energy (1 to l00eV), and fragment ions are mass analyzed in a fast and short TOF2, operating at much higher keV energy. Low energy fragmentation cell between TOF1 and TOF2 is tailored to accelerate fragmentation and dampening steps, mostly by shortening the cell and employing higher gas pressure. Since separation in TOF1 takes milliseconds and mass analysis in TOF2- microseconds, the invention provides comprehensive MS-MS analysis of multiple precursor ions per single ion pulse. Slow separation in TOF1 becomes possible with an introduction of novel TOF1 analyzers. The TOF-TOF could be implemented using a static TOF1, here described on the examples of spiratron, planar and cylindrical multi-pass separators with griddles spatial focusing ion mirrors. Higher performance is expected with the use of novel hybrid TOF 1 analyzers, combining radio frequency (RF) and quadratic DC fields. RF field retains low-energy ions within TOF 1 analyzer, while quadratic DC field improves resolution by compensate for large relative energy spread.

Description

technical field [0001] The present invention relates to the field of mass spectrometry, and more particularly to a high-throughput, integrated tandem mass spectrometry method in a device containing two time-of-flight mass spectrometers. Background technique [0002] A mass spectrometer is a device that vaporizes and ionizes a sample, then uses a static or dynamic electric field to measure the mass-to-charge ratio of the ions formed. Tandem mass spectrometry is used for structural analysis and identification of compounds in complex mixtures. Within each application, the MS-MS program has the same sequence of operations: [0003] Mass selection of precursor ions of a single mass-to-charge ratio (m / z); [0004] Fragmentation of these ions; [0005] • Mass spectrometric analysis of these fragments. Although there are various serial MS-MS instruments with their own pros and cons, they all share one characteristic—they all use one precursor ion at a time. The remaining ion nu...

Claims

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Application Information

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IPC IPC(8): G01N27/62H01J49/06H01J49/10H01J49/40
CPCH01J49/406H01J49/004G01N27/623
Inventor 阿纳托利·N.·韦伦奇克沃
Owner 力可公司
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