482results about "Electron/ion optical arrangements" patented technology

A method of separating ions based on mobility is provided. The method involves receiving ions by an ion mobility spectrometry device having a separation region, and causing the ions to travel through at least a portion of the separation region in a first direction along a path and separate based on ion mobility. The method further involves causing the separated ions to maintain a relative degree of separation therebetween and travel in a second direction along the path while maintaining the relative degree of separation therebetween. The second direction being opposite to the first direction. The ions are then caused to travel in the first direction along the path a second time to further separate the ions based on ion mobility. An ion mobility spectrometry device performing the foregoing method is also provided.

Systems and methods described herein provide for charge state control of multiply-charged anions in a front end, high pressure ion guide. In some example aspects, a mass spectrometer system is provided comprising a first vacuum chamber (121) maintained at a pressure above about 500 mTorr. At least one ion guide (106) is disposed within the first vacuum chamber, the at least one ion guide comprising a plurality of rods extending along a central longitudinal axis. A controller (193) is configured to adjust an amplitude of an RF voltage signal provided to the plurality of rods so as to alternatively operate the ion guide in a first mode of operation with a lower amplitude of the RF voltage signal so as to reduce the likelihood of charge reduction by electron detachment so as to substantially maintain the isotopic distribution of the ions during transmission of ions through the ion guide, and a second mode of operation with a higher amplitude of the RF voltage signal so as to increase the likelihood of electron detachment from ions being transmitted therethrough.

The invention relates to the technical field of ion characterization and preparation, in particular to a high-throughput preparation mass spectrum device and method giving consideration to high-resolution characterization. The device comprises an ion source, an ion transmission cavity, a quadrupole mass screening cavity, an ion dissociation cavity, an ion deflection cavity, an ion deceleration and deposition cavity and a high-resolution mass spectrum characterization cavity which are sequentially arranged, wherein the high-resolution mass spectrum characterization cavity is formed in one side of the ion deflection cavity in the vertical direction; soft ionization is combined with a quadrupole analyzer to screen ions, the ions are dissociated through a dissociation cavity, an ion deflection cavity is used for selecting a high-resolution characterization or high-throughput preparation function, a high-resolution mass spectrum characterization cavity is used for achieving high-resolution characterization of screened and fragmented ions, and an ion deceleration and deposition cavity is used for high-throughput preparation of the ions. According to the method, perfect compatibility of high-throughput preparation and high-resolution mass spectrum characterization is realized through ion deflection design, and the method has a wide application prospect in the fields of efficient preparation of biological macromolecules, synthetic macromolecules and the like and the like.

An orthogonal acceleration time-of-flight mass spectrometer includes: a first vacuum chamber and a second vacuum chamber; an insulating spacer member; a former-stage-side ring electrode; subsequent-stage-side ring electrodes; a first fixation member including a first displacement member to displace a central axis of the former-stage-side ring electrode and the subsequent-stage-side ring electrodes in a predetermined direction orthogonal to the central axis by thermal expansion; and a second fixation member including a second displacement member to displace the central axis in the predetermined direction orthogonal to the central axis by thermal expansion, a difference between a thermal expansion amount of the first displacement member per unit temperature and a thermal expansion amount of the second displacement member per unit temperature being 30% or less of the thermal expansion amount of the first displacement member.

Disclosed are methods, systems, apparatus, devices, and other implementations, that include a mass spectrometry (MS) system including a casing defining a cavity, a removable ion guide sub-assembly configured to be disposed within the cavity and including at least two mechanically coupled ion guides each defining a separate chamber at different pressures when engaged with the casing, with the removable ion guide sub-assembly including one or more insertion alignment elements to rotationally and / or angularly align the ion guide assembly for insertion into the cavity, and one or more receiving alignment elements disposed in the cavity and configured to receive a corresponding one of the one or more insertion alignment elements. The ion guide sub-assembly is configured to be axially removable from the casing with the at least two ion guides remaining mechanically coupled to each other and retaining the casing upon removal of the ion-guide sub-assembly from the casing.

The invention relates to the technical field of vacuum equipment, and discloses an ion lens assembly, an ion source, a mass spectrometer and a mass spectrometry system. The ion lens assembly includes a deflection lens assembly and a return lens assembly. The deflection lens assembly is used for focusing an ion beam in the incident particle beam and enabling the ion beam to deflect towards a first direction. And the axis-returning lens assembly is used for receiving the ion beam from the deflection lens assembly, and the axis-returning lens assembly is used for focusing the received ion beam and enabling the ion beam to deflect towards a second direction.

Disclosed are methods, systems, apparatus, devices, and other implementations, that include a mass spectrometry (MS) system including a casing defining a cavity, a removable ion guide sub-assembly configured to be disposed within the cavity and including at least two mechanically coupled ion guides each defining a separate chamber at different pressures when engaged with the casing, with the removable ion guide sub-assembly including one or more insertion alignment elements to rotationally and / or angularly align the ion guide assembly for insertion into the cavity, and one or more receiving alignment elements disposed in the cavity and configured to receive a corresponding one of the one or more insertion alignment elements. The ion guide sub-assembly is configured to be axially removable from the casing with the at least two ion guides remaining mechanically coupled to each other and retaining the casing upon removal of the ion-guide sub-assembly from the casing.

A mass or mobility spectrometer comprising: a first vacuum chamber; and a collision cell arranged in the first vacuum chamber, wherein the collision cell comprises: an ion entrance at an upstream end thereof; an ion exit at a downstream end thereof; a main body portion between the ion entrance and ion exit; and an elongated tube between the main body portion and the ion exit. The collision cell comprises one or more ion guide extending through the main body portion, and / or through the elongated tube, for radially confining ions within the one or more ion guide. The spectrometer is configured to maintain the main body portion of the collision cell at a higher pressure than the first vacuum chamber; and the elongated tube is configured to limit the gas conductance out of the downstream end of the collision cell.

An apparatus for analyzing peak data generated from mass signals acquired by a mass spectrometric system comprises: a streaming device that comprises a first network interface and is configured to generate peak data from the mass signals or receive peak data generated externally from the mass signals, group the peak data into independently-processable data packets related to a processing task, and distribute the data packets in a task-specific stream via the first network interface onto a network; and at least one analyzing device that comprises a second network interface and is configured to retrieve a data packet of the task-specific stream via the second network interface from the network, perform the processing task on the retrieved data packet to produce result data, package the result data in a result data packet, and distribute the result data packet via the first network interface onto the network.

The invention relates to the technical field of analysis instrument ionization sources, in particular to a VUV lamp ionization source device with efficient heat dissipation capacity. The device comprises a VUV lamp, a heat dissipation unit, a VUV lamp driving electrode, a driving circuit and an ion guide focusing unit. The heat dissipation unit carries out cooperative heat dissipation on the VUV lamp and the pulse transformer through a fan, and the problems of signal attenuation and device aging caused by temperature rise are solved. The driving electrode adopts a pairwise pairing structure of upper and lower and left and right electrode pairs to form an inclined electric field to prevent ions from bombarding the lamp wall and the light window; the drive circuit is a half-bridge or full-bridge topology, can adjust the pulse frequency and the power supply voltage, and achieves the switching between a high-voltage low-frequency mode and a low-voltage high-frequency mode. The ion guide focusing unit efficiently leads out and separates ions through cooperation of a conical focusing electric field and a conductive film forward electric field. Through four-dimensional innovation of heat dissipation, electrodes, driving and transmission, the stability, the service life and the detection sensitivity of the device are improved, and the device is suitable for analytical instruments such as ion mobility spectrometry and mass spectrometry.

Systems and methods are disclosed for dynamically switching an ion guide and a TOF mass analyzer between concentrating or not concentrating ions in a targeted acquisition. Product ions are ejected from the ion guide into the TOF mass analyzer and the intensity of a known product ion is measured at two or more time steps. The ion guide initially ejects product ions using a sequential or Zeno pulsing mode that concentrates product ions with different m / z values within the TOF mass analyzer at the same time. If the intensity of the product ion is increasing and greater than a threshold intensity, the ion guide switches to a continuous or normal pulsing mode that does not concentrate ions with different m / z values in the TOF mass analyzer at the same time. Similarly, if the intensity decreases below a threshold in continuous mode, the ion guide switches back to sequential mode.

Methods and systems are provided herein for selectively removing product ions resulting from an ECD dissociation event from the interaction region of an ECD reaction cell, while other precursor peptide ions continue to undergo ECD within the interaction region, thereby reducing or preventing the occurrence of multiple electron capture events by the product ions. In some aspects, the preferential extraction of product ions from the interaction region during the ECD reaction can occur without an auxiliary AC field being generated within the interaction region. Additionally, in some aspects, the methods and systems disclosed herein can subject the various product ions to a non-dissociative charge reduction via exposure to reagent ions of the opposite polarity so as to selectively concentrate product ions to a lower charge state.

A miniature electrode apparatus is disclosed for trapping charged particles, the apparatus includes, along a longitudinal direction, a first end cap electrode, a central electrode having an aperture, and a second end cap electrode. The aperture is elongated in the lateral plane and extends through the central electrode along the longitudinal direction and the central electrode surrounds the aperture in a lateral plane perpendicular to the longitudinal direction to define a transverse cavity for trapping charged particles. Electric fields can be applied in a y-direction of the lateral plane across one or more planes perpendicular to the longitudinal axis to translocate and / or manipulate ion trajectories.

The present invention provides an ion detector that can suppress variations in ion detection time for ions with the same mass-to-charge ratio, and a mass spectrometer that can improve the resolution of mass spectrometry. [Solution] The ion detector 1A includes a conversion unit 2A that emits electrons e to the other side of direction D when ions i are incident from one side in direction D, and an output unit 3 that outputs an electrical signal in response to the incidence of electrons e emitted from the conversion unit 2A. The conversion unit 2A includes a support having a support surface perpendicular to direction D, and an electron generation layer disposed on the support surface that generates electrons e in response to the incidence of ions i. The support has a plurality of passages through which ions i or electrons e pass. The plurality of passages are arranged two-dimensionally along the support surface.

According to the ion regulation and control device, the ion guide device, the control method, the device, the equipment and the ion guide system provided by the invention, the first guide element and the deflection force field generation module are arranged, under the condition that ions are injected into the first guide element, the first guide element is controlled to apply the reverse electric field opposite to the ion transmission direction, and the deflection force field is generated; thereby trapping ions within the first guide element; controlling the deflection force field generation module to work so as to enable the ions in the first guide element to generate radial deflection; and under the condition that offset is completed, the first guide element is controlled to cancel the reverse electric field so that the first guide element can move in the transmission direction, ions in the first guide element can generate radial offset through the deflection force field generation module, the ions can be more uniformly distributed in the radial direction, and therefore the space area utilization rate is increased, and the transmission efficiency is improved. And the influence of the space charge effect is reduced.

The invention relates to an ion-optical component comprising at least one electrode arrangement (12) with a circular segment-shaped inner electrode (17) and an annular segment-shaped outer electrode (18) circumferentially surrounding the inner electrode (17), as well as with two circular segment-shaped plates (23) which are surrounded on both sides of the inner electrode (17) and circumferentially by the outer electrode (18) and form a uniform annular segment-shaped gap (25) between each of the plates (23) and the outer electrode (18), wherein the ion-optical component comprises two electrode arrangements (12) which each extend over a sector with an angle ϕ / 2, where 90°<ϕ<180°, and are arranged one behind the other in such a way that a trajectory of an ion beam (14) through the ion-optical component is s-shaped.

An apparatus for ion manipulations includes an ion manipulation path extending between an inlet and an outlet, at least one continuous electrode configured to receive a first RF voltage signal, and a plurality of segmented electrodes configured to receive a second voltage signal and generate a traveling wave field based thereon. The ion manipulation path includes a first region extending in a first direction, a second region extending in a second direction, and a curved region extending between the first and second regions. The at least one continuous electrode extends through the first region, the curved region, and second region. The segmented electrodes are arranged along the ion manipulation path in the first region, the curved region, and the second region. The traveling wave field is configured to cause ions to travel through, the first region, the curved region, and the second region.

The utility model discloses a Faraday cup of an ion receiver of a thermal ionization mass spectrometer, which comprises a non-metal receiving support, a non-metal receiving electrode and a pair of external fixing metal plates, the non-metal receiving support is concaved inwards to form a notch communicated with the outside, the non-metal receiving electrode is arranged in the notch, and the external fixing metal plates are fixed on the non-metal receiving support. The pair of external fixing metal plates are oppositely fixed on the two side surfaces of the non-metal receiving bracket, and the external fixing metal plates and the non-metal receiving bracket are encircled to enable the notch to only have a state that the top is communicated with the outside, so that the whole Faraday cup retains the rigidity of metal, the outside is not easy to deform, and the service life of the Faraday cup is prolonged. The non-metallic material is adopted in the device, so that the device has the characteristic of not rebounding ions, interference on ion measurement can be effectively reduced, and the measurement accuracy is improved.

A radio frequency (RF) choke for use within a mass spectrometer comprises a bobbin having a hollow channel, a plurality of wire windings wound around the bobbin, each of the wire windings presenting a lattice winding pattern having a number of crossovers per turn of from about 1 to about 4, and a magnetic core disposed within the hollow channel of the bobbin. The RF choke exhibits an impedance in the range of from about 15 M ohms to about 150 M ohms with respect to an RF frequency generated by an RF voltage source within the range of from about 500 KHz to about 3 MHz, and a power dissipation equal to, or less than, about 3 W with respect to a peak-to-peak RF voltage of an RF voltage source of at least about 1 kV.

An ion focusing device comprising an ion collection element comprising a plurality of N curved electrodes extending around an axis of the ion collection element and an aperture on an axis of the ion collection element. A multipole ion guide adjacent the ion collection element and having a plurality of N elongate electrodes extending parallel to and around an axis of the multipole ion guide, wherein the axis of the multipole ion guide coincides with the axis of the ion collection element, wherein each of the N curved electrodes of the ion collection element are configured to receive a radio frequency, RF, signal having the same phase as an RF signal configured to be applied to at least one elongate electrode of the plurality of elongate electrodes of the multipole ion guide, and further wherein at least two of the N electrodes of the ion collection element are configured to receive RF signals of a different phase.

The present invention relates to an apparatus for analyzing peak data generated from a mass signal acquired by a mass spectrometry system, comprising: a streaming device including a first network interface and configured to (a) generate peak data from the acquired mass signal or receive peak data generated externally from the acquired mass signal, (b) group the peak data into a plurality of independently processable data packets, the data packets relating to a processing task, and (c) distribute the data packets as a task-specific stream onto a network via the first network interface; and at least one analysis device including a second network interface and configured to (a) retrieve data packets of a task-specific stream from the network via the second network interface, (b) perform a processing task on the retrieved data packets to generate result data, (c) encapsulate the result data in a result data packet, and (d) distribute the result data packet onto the network via the first network interface.

A multipole ion guide for a mass spectrometer comprises: a plurality of rods; a support configured to support the plurality of rods; a first temperature sensor configured to directly measure a temperature of at least one rod of the plurality of rods; and a second temperature sensor configured to directly measure the temperature of the support.

An ion optic device comprising a plurality of stacked electrodes 201 arranged on a support member, an electrically insulating sleeve 206 extending through apertures in the electrodes; and a fastener s

Method and system for calibrating a mass spectrometer having one or more ion lenses and a mass analyser, the method comprising the steps of acquiring from the mass analyser a plurality of mass spectra from a sample, the sample comprising a plurality of ion masses, wherein a voltage value applied to the one or more ion lenses is static while each mass spectrum is obtained and the voltage value is varied between different mass spectra. Determining from the plurality of mass spectra and corresponding voltage applied to the one or more ion lenses during acquisition of each mass spectrum, a voltage value providing an optimum ion signal for each of the plurality of ion masses in the sample. Storing data indicating the ion mass value and corresponding voltage value providing the optimum ion signal for each of the plurality of ion masses in the sample.

An ion isolation apparatus and method or system using one or more auxiliary electrodes in an ion reactor having an RF electrode adapted to direct positively charged precursor ions along a first axis and an electron source for introducing an electron beam along a second axis transverse to the first axis such that electronically activated dissociation of the precursor ions into reaction products can occur, wherein the auxiliary electrode is configured to apply a complementary AC signal to enable selective extraction of the reaction products while isolating the precursor ions along the second central axis. For example, the complementary AC signal can comprise a notched white noise signal with a notch that suppresses frequencies at which precursor ions (and / or reduced charge species having the same molecular mass but a different charge state) would otherwise be excited.

The invention provides a winding type ion transmission device based on a flexible printed circuit board, which not only can realize high-efficiency transmission of ions from a high-air-pressure ion source to a high-vacuum mass analyzer, but also can solve the problems of difficulty in machining and manufacturing, high cost, poor batch consistency and the like of a traditional metal machine. Comprising a flexible printed circuit board, the flexible printed circuit board is wound to form a conical ion transmission channel, a plurality of electrode sets are annularly arranged on the wound flexible printed circuit board, and each electrode set comprises a plurality of electrodes sequentially arranged in the axial direction of the ion transmission channel. Voltages with different phases are applied to the electrode group, so that a radial resonance bound electric field is formed, and a continuous axial direct-current gradient field of which the voltage drop is gradually reduced along the ion transmission direction is formed.

A component of an ion optical device is manufactured. The component comprises aligned first and second electrode sets. A first material is machined to provide a part-machined first electrode set that comprises the first electrode set attached to a frame part of the first material. A second material is machined to provide a part-machined second electrode set that comprises the second electrode set attached to a frame part of the second material. The component of the ion optical device is assembled by aligning the part-machined first and second electrode sets. Subsequent to aligning the part-machined first and second electrode sets, the part-machined first electrode set is further machined to separate the first electrode set from the frame part of the first material and the part-machined second electrode set is further machined to separate the second electrode set from the frame part of the second material.

In one aspect, an ion guiding assembly for use in a mass spectrometry system is disclosed that includes a first plurality of multipole rods arranged to allow ions to pass therebetween, a second plurality of multipole rods arranged to allow ions to pass therebetween, and a plate disposed between the first plurality of rods and the second plurality of rods, the plate including an ion lens. The first plurality of rods and the second plurality of rods are coupled to the plate, and rods of the first plurality of rods are pairwise aligned with and coupled to rods of the second plurality of rods.

In some examples, a multipole ion guide may include a plurality of electrode groups that are arranged circumferentially around an axis of the multipole ion guide. At least one electrode group of the plurality of electrode groups may include at least three electrodes that are disposed in a side-by-side configuration.

This invention relates to a high-efficiency ion current acquisition structure and a mass spectrometer. The ion current acquisition structure includes: a collection chamber adapted to be installed between the ion source and the sampling cone of the mass spectrometer; a trumpet-shaped aperture disposed within the collection chamber at the end facing the ion source; an annular electrode disposed on the inner wall of the trumpet-shaped aperture; and a beam rod assembly comprising multiple rod-shaped electrodes uniformly arranged circumferentially along the outlet of the trumpet-shaped aperture, with adjacent rod-shaped electrodes spaced apart to form gaps; wherein, on the side away from the ion source, the ends of the multiple rod-shaped electrodes are all bent and converged towards the central axis of the collection chamber. This invention provides a high-efficiency ion current acquisition structure that can improve the technical problems of low ion acquisition efficiency before entering the vacuum system and high background noise caused by the inability to effectively filter neutral particles in the prior art.