765results about "Electron/ion optical arrangements" patented technology

The invention discloses a self-constrained transverse extension ion optical lens device, and belongs to the technical field of cluster ion lens devices. The invention discloses a self-constrained transverse extension ion optical lens device which comprises a cuboid vacuum cavity and an ion lens device. The ion lens device comprises an entrance slit of an ion optical lens, an exit slit of the ion optical lens and an electrode group; the electrode group comprises a conical plate electrode group and a parallel plate electrode group; a crack at the head end of the conical plate electrode group forms an inlet slit of the ion optical lens, the tail end of the conical plate electrode group is connected with the head end of the parallel plate electrode group, and a crack at the tail end of the parallel plate electrode group forms an outlet slit of the ion optical lens; one side of the cuboid vacuum cavity is provided with a cluster beam generation device outlet, and the ion lens device is arranged in the cuboid vacuum cavity. Under the condition that the beam density in the prior art is kept unchanged, the cluster beam intensity entering and leaving the ion optical part is increased, and the cluster yield is improved.

The invention discloses a novel ion transmission focusing device, and belongs to the technical field of ion transmission. The flow limiting device comprises a flow limiting hole and an octupole rod device, each flow limiting hole is a metal plate with a small hole in the center, the two flow limiting holes form a vacuum differential cavity, and certain direct-current voltage is applied to the flow limiting holes. The octupole rod device comprises two insulating positioning rings and eight conical electrode rods which are arranged at equal intervals to form a cone shape, the eight conical electrode rods are fixed through the insulating positioning rings, and the two ends of the octupole rod are connected with an ion source outlet and a mass selector inlet respectively; every four adjacent electrodes are connected through a copper sheet to form two electrodes, and the two electrodes apply two radio frequency voltages with the same amplitude and opposite phases through a power supply. The ion transmission system can be used for focusing and transmission of cluster beams, and effectively improves the beam density in a low vacuum environment. The whole device is simple in structure, easy to machine and low in cost.

A method of separating ions based on mobility is provided. The method involves receiving ions by an ion mobility spectrometry device having a separation region, and causing the ions to travel through at least a portion of the separation region in a first direction along a path and separate based on ion mobility. The method further involves causing the separated ions to maintain a relative degree of separation therebetween and travel in a second direction along the path while maintaining the relative degree of separation therebetween. The second direction being opposite to the first direction. The ions are then caused to travel in the first direction along the path a second time to further separate the ions based on ion mobility. An ion mobility spectrometry device performing the foregoing method is also provided.

Systems and methods described herein provide for charge state control of multiply-charged anions in a front end, high pressure ion guide. In some example aspects, a mass spectrometer system is provided comprising a first vacuum chamber (121) maintained at a pressure above about 500 mTorr. At least one ion guide (106) is disposed within the first vacuum chamber, the at least one ion guide comprising a plurality of rods extending along a central longitudinal axis. A controller (193) is configured to adjust an amplitude of an RF voltage signal provided to the plurality of rods so as to alternatively operate the ion guide in a first mode of operation with a lower amplitude of the RF voltage signal so as to reduce the likelihood of charge reduction by electron detachment so as to substantially maintain the isotopic distribution of the ions during transmission of ions through the ion guide, and a second mode of operation with a higher amplitude of the RF voltage signal so as to increase the likelihood of electron detachment from ions being transmitted therethrough.

Methods include introducing an ion quantity into an ion accumulation region, wherein the ion accumulation region, which can comprise a structure for lossless ion manipulations (SLIM) device allowing creation of a static or traveling wave electric field that moves ions towards an ion wall controllably blocking a movement of the ion quantity past the ion wall, wherein the ion wall is produced by one or more ion wall electrodes of an electrode arrangement, and directing the ion quantity in a direction towards the ion wall to increase a density of the ion quantity adjacent to the ion wall, such that the quantity of ions becomes space charge separated based on mobility along the direction and adjacent to the ion wall. Related apparatus provide space charge driven mobility separations.

The invention relates to the technical field of ion characterization and preparation, in particular to a high-throughput preparation mass spectrum device and method giving consideration to high-resolution characterization. The device comprises an ion source, an ion transmission cavity, a quadrupole mass screening cavity, an ion dissociation cavity, an ion deflection cavity, an ion deceleration and deposition cavity and a high-resolution mass spectrum characterization cavity which are sequentially arranged, wherein the high-resolution mass spectrum characterization cavity is formed in one side of the ion deflection cavity in the vertical direction; soft ionization is combined with a quadrupole analyzer to screen ions, the ions are dissociated through a dissociation cavity, an ion deflection cavity is used for selecting a high-resolution characterization or high-throughput preparation function, a high-resolution mass spectrum characterization cavity is used for achieving high-resolution characterization of screened and fragmented ions, and an ion deceleration and deposition cavity is used for high-throughput preparation of the ions. According to the method, perfect compatibility of high-throughput preparation and high-resolution mass spectrum characterization is realized through ion deflection design, and the method has a wide application prospect in the fields of efficient preparation of biological macromolecules, synthetic macromolecules and the like and the like.

An orthogonal acceleration time-of-flight mass spectrometer includes: a first vacuum chamber and a second vacuum chamber; an insulating spacer member; a former-stage-side ring electrode; subsequent-stage-side ring electrodes; a first fixation member including a first displacement member to displace a central axis of the former-stage-side ring electrode and the subsequent-stage-side ring electrodes in a predetermined direction orthogonal to the central axis by thermal expansion; and a second fixation member including a second displacement member to displace the central axis in the predetermined direction orthogonal to the central axis by thermal expansion, a difference between a thermal expansion amount of the first displacement member per unit temperature and a thermal expansion amount of the second displacement member per unit temperature being 30% or less of the thermal expansion amount of the first displacement member.

The invention relates to a continuous ion beam screening and enriching system and method and a mass spectrograph, and the continuous ion beam screening and enriching system comprises a vacuum differential unit, a first ion focusing unit, a mass screening unit, a second ion focusing unit, an enriching and releasing unit and a third ion focusing unit which are sequentially arranged from upstream to downstream. The enrichment and release unit is provided with a shell and a plurality of annular electrode plates which are arranged in parallel and located in a cavity of the shell, a resistor and a capacitor are connected between every two adjacent annular electrode plates to form a gradient electric field, and center holes of the annular electrode plates are concentrically arranged to jointly form an ion channel penetrating between an inlet and an outlet of the enrichment and release unit. According to the invention, continuous ion beam low-energy-consumption enrichment and pulse release can be realized, and strict requirements of scientific and industrial fields on mass spectrum detection and ion control precision are met.

Disclosed are methods, systems, apparatus, devices, and other implementations, that include a mass spectrometry (MS) system including a casing defining a cavity, a removable ion guide sub-assembly configured to be disposed within the cavity and including at least two mechanically coupled ion guides each defining a separate chamber at different pressures when engaged with the casing, with the removable ion guide sub-assembly including one or more insertion alignment elements to rotationally and / or angularly align the ion guide assembly for insertion into the cavity, and one or more receiving alignment elements disposed in the cavity and configured to receive a corresponding one of the one or more insertion alignment elements. The ion guide sub-assembly is configured to be axially removable from the casing with the at least two ion guides remaining mechanically coupled to each other and retaining the casing upon removal of the ion-guide sub-assembly from the casing.

The invention relates to the technical field of vacuum equipment, and discloses an ion lens assembly, an ion source, a mass spectrometer and a mass spectrometry system. The ion lens assembly includes a deflection lens assembly and a return lens assembly. The deflection lens assembly is used for focusing an ion beam in the incident particle beam and enabling the ion beam to deflect towards a first direction. And the axis-returning lens assembly is used for receiving the ion beam from the deflection lens assembly, and the axis-returning lens assembly is used for focusing the received ion beam and enabling the ion beam to deflect towards a second direction.

A method and corresponding devices to reduce the presence of unwanted ions within the pseudo-potential well of the RF fields for inductively coupled plasma mass spectrometry is disclosed. This method reduces space-charge effects and leaves more room available for the ions of interest and, hence, leads to increased transmission of the desired ions into the mass analyzer. In the present invention, the space charge is reduced by adding a low-band resolving DC potential, or a fast sweeping resolving DC potential with a notch, or a fast constant resolving DC potential with a notch, or by adding auxiliary quadrupolar or dipolar RF potential to the quadrupole ion guide, such that all the unwanted ions will be outside the stable region and therefore ejected. This reduces the charge density in the ion beam and ameliorate space charge effects.

Disclosed are methods, systems, apparatus, devices, and other implementations, that include a mass spectrometry (MS) system including a casing defining a cavity, a removable ion guide sub-assembly configured to be disposed within the cavity and including at least two mechanically coupled ion guides each defining a separate chamber at different pressures when engaged with the casing, with the removable ion guide sub-assembly including one or more insertion alignment elements to rotationally and / or angularly align the ion guide assembly for insertion into the cavity, and one or more receiving alignment elements disposed in the cavity and configured to receive a corresponding one of the one or more insertion alignment elements. The ion guide sub-assembly is configured to be axially removable from the casing with the at least two ion guides remaining mechanically coupled to each other and retaining the casing upon removal of the ion-guide sub-assembly from the casing.

A mass spectrometry system that includes first and second ion sources that produce ions, the ions produced by the second ion source being calibration ions to calibrate the mass spectrometry system; an ion transfer device that receives the ions as a continuous stream during a first time period and forms a first ion packet as a single ion packet, such that during a second time period when the ion transfer device delivers the first ion packet, it receives the ions as a continuous stream to form a second ion packet by accumulating the incoming ions in another single ion packet, such that the ion transfer device separately delivers the formed ion packets at a frequency in a range from 1 to 1000 Hz; and a mass analyzer that separates the ions in the ion packets based on the mass-to-charge ratio of the ions.

A mass or mobility spectrometer comprising: a first vacuum chamber; and a collision cell arranged in the first vacuum chamber, wherein the collision cell comprises: an ion entrance at an upstream end thereof; an ion exit at a downstream end thereof; a main body portion between the ion entrance and ion exit; and an elongated tube between the main body portion and the ion exit. The collision cell comprises one or more ion guide extending through the main body portion, and / or through the elongated tube, for radially confining ions within the one or more ion guide. The spectrometer is configured to maintain the main body portion of the collision cell at a higher pressure than the first vacuum chamber; and the elongated tube is configured to limit the gas conductance out of the downstream end of the collision cell.

In one aspect, an ion guide assembly for use in a mass spectrometry system is disclosed, which comprises a first plurality of multipole rods that are arranged to allow passage of ions therebetween, a second plurality of multipole rods that are arranged to allow passage of ions therebetween, and a board disposed between the first and second plurality of rods, the board comprising an ion lens. The first and second plurality of rods are coupled to the board, and the rods of the first plurality of rods are pairwise aligned with, and coupled to, rods of the second plurality of rods.

A curved multipole collision reaction cell for an inductively coupled plasma mass spectrometer, comprising: a housing comprising a cell inlet, a cell outlet disposed opposite the cell inlet along a longitudinal axis of the housing, and a gas supply port in communication with an internal structure of the housing; and a curved multi-pole ion guide disposed inside the housing along a longitudinal axis of the housing, the curved multi-pole ion guide configured to generate an RF confinement field effective to constrain ions in a radial direction orthogonal to the longitudinal axis of the housing, while the curved multi-pole ion guide is disposed inside the housing along the longitudinal axis of the housing, and the curved multi-pole ion guide is configured to generate an RF confinement field effective to constrain ions in a radial direction orthogonal to the longitudinal axis of the housing. And separating neutral substances from photons and ions. In addition, by adopting the plasma mass spectrometry system of the collision reaction tank provided by the invention, the instrument volume of a mass spectrometer can be greatly reduced, and miniaturization is realized.

The invention relates to a mass spectrometry technology, and particularly provides an ion focusing method which comprises the following steps: (A1) ions sequentially pass through an incident lens, a multi-pole rod and an emergent lens; (A2) a compensation voltage E is obtained according to the mass and the charge number of the ions; and (A3) the compensation voltage E is applied to the incident lens and the emergent lens, and ions are focused at an inlet of the incident lens and an outlet of the emergent lens respectively. The invention has the advantages of good focusing effect and the like, and is applied to ion transmission.

An apparatus for analyzing peak data generated from mass signals acquired by a mass spectrometric system comprises: a streaming device that comprises a first network interface and is configured to generate peak data from the mass signals or receive peak data generated externally from the mass signals, group the peak data into independently-processable data packets related to a processing task, and distribute the data packets in a task-specific stream via the first network interface onto a network; and at least one analyzing device that comprises a second network interface and is configured to retrieve a data packet of the task-specific stream via the second network interface from the network, perform the processing task on the retrieved data packet to produce result data, package the result data in a result data packet, and distribute the result data packet via the first network interface onto the network.

The invention belongs to the technical field of component detection, and relates to a three-state ion gate and a Hadamard transform ion mobility spectrometer. The three-state ion gate is arranged in the Hadamard transform ion mobility spectrometer and comprises a first grid mesh, a second grid mesh and a third grid mesh which are sequentially and separately arranged in the direction from a reaction region to a drift region; the grid voltage regulation and control module is used for controlling the voltage of the second grid to be larger than the voltage of the third grid and smaller than the voltage of the first grid within a first preset time when the modulation signal output by the spectral modulation Hadamard transform gating unit is a first level signal; when the modulation signal is converted from the first level signal to the second level signal, controlling the voltage of the second grid mesh to be greater than the voltage of the first grid mesh and the voltage of the third grid mesh within a second preset time; and when the modulation signal is a continuous second level signal, controlling the voltage of the second grid mesh to be smaller than the voltage of the first grid mesh and the third grid mesh. According to the scheme, the resolution and the signal-to-noise ratio of the ion mobility spectrometry obtained by the Hadamard transform example mobility spectrometer can be improved.

The invention relates to the technical field of analysis instrument ionization sources, in particular to a VUV lamp ionization source device with efficient heat dissipation capacity. The device comprises a VUV lamp, a heat dissipation unit, a VUV lamp driving electrode, a driving circuit and an ion guide focusing unit. The heat dissipation unit carries out cooperative heat dissipation on the VUV lamp and the pulse transformer through a fan, and the problems of signal attenuation and device aging caused by temperature rise are solved. The driving electrode adopts a pairwise pairing structure of upper and lower and left and right electrode pairs to form an inclined electric field to prevent ions from bombarding the lamp wall and the light window; the drive circuit is a half-bridge or full-bridge topology, can adjust the pulse frequency and the power supply voltage, and achieves the switching between a high-voltage low-frequency mode and a low-voltage high-frequency mode. The ion guide focusing unit efficiently leads out and separates ions through cooperation of a conical focusing electric field and a conductive film forward electric field. Through four-dimensional innovation of heat dissipation, electrodes, driving and transmission, the stability, the service life and the detection sensitivity of the device are improved, and the device is suitable for analytical instruments such as ion mobility spectrometry and mass spectrometry.

Systems and methods are disclosed for dynamically switching an ion guide and a TOF mass analyzer between concentrating or not concentrating ions in a targeted acquisition. Product ions are ejected from the ion guide into the TOF mass analyzer and the intensity of a known product ion is measured at two or more time steps. The ion guide initially ejects product ions using a sequential or Zeno pulsing mode that concentrates product ions with different m / z values within the TOF mass analyzer at the same time. If the intensity of the product ion is increasing and greater than a threshold intensity, the ion guide switches to a continuous or normal pulsing mode that does not concentrate ions with different m / z values in the TOF mass analyzer at the same time. Similarly, if the intensity decreases below a threshold in continuous mode, the ion guide switches back to sequential mode.

A sampling interface 100 for use in mass spectroscopy apparatus, comprising: an inlet 110 for receiving a quantity of particles from an ion source; a skimmer 115 having an aperture arranged downstream

Methods and systems are provided herein for selectively removing product ions resulting from an ECD dissociation event from the interaction region of an ECD reaction cell, while other precursor peptide ions continue to undergo ECD within the interaction region, thereby reducing or preventing the occurrence of multiple electron capture events by the product ions. In some aspects, the preferential extraction of product ions from the interaction region during the ECD reaction can occur without an auxiliary AC field being generated within the interaction region. Additionally, in some aspects, the methods and systems disclosed herein can subject the various product ions to a non-dissociative charge reduction via exposure to reagent ions of the opposite polarity so as to selectively concentrate product ions to a lower charge state.

The invention discloses an ion source extraction electrode system for eliminating image bending, which comprises a plasma electrode, an extraction electrode surrounded by the plasma electrode and a beam control electrode surrounded by the extraction electrode, and the electrodes are arranged in a mutually separated manner; an ion extraction part of the plasma electrode is provided with a first strip-shaped slit with a first arc-shaped opening; the extraction electrode is provided with a second strip-shaped slit with a second arc-shaped opening; the beam control electrode is provided with a third strip-shaped slit with a third arc-shaped opening; the first strip-shaped slit, the second strip-shaped slit and the third strip-shaped slit are oppositely arranged; the invention aims to solve a plurality of technical problems existing in an extraction electrode system and a collector in an existing isotope electromagnetic separator, including but not limited to the problems of bending, frequent sparking phenomenon, heat effect caused by dark current, vulnerability of a collector panel, lack of universality and the like.

A miniature electrode apparatus is disclosed for trapping charged particles, the apparatus includes, along a longitudinal direction, a first end cap electrode, a central electrode having an aperture, and a second end cap electrode. The aperture is elongated in the lateral plane and extends through the central electrode along the longitudinal direction and the central electrode surrounds the aperture in a lateral plane perpendicular to the longitudinal direction to define a transverse cavity for trapping charged particles. Electric fields can be applied in a y-direction of the lateral plane across one or more planes perpendicular to the longitudinal axis to translocate and / or manipulate ion trajectories.

The present invention provides an ion detector that can suppress variations in ion detection time for ions with the same mass-to-charge ratio, and a mass spectrometer that can improve the resolution of mass spectrometry. [Solution] The ion detector 1A includes a conversion unit 2A that emits electrons e to the other side of direction D when ions i are incident from one side in direction D, and an output unit 3 that outputs an electrical signal in response to the incidence of electrons e emitted from the conversion unit 2A. The conversion unit 2A includes a support having a support surface perpendicular to direction D, and an electron generation layer disposed on the support surface that generates electrons e in response to the incidence of ions i. The support has a plurality of passages through which ions i or electrons e pass. The plurality of passages are arranged two-dimensionally along the support surface.

According to the ion regulation and control device, the ion guide device, the control method, the device, the equipment and the ion guide system provided by the invention, the first guide element and the deflection force field generation module are arranged, under the condition that ions are injected into the first guide element, the first guide element is controlled to apply the reverse electric field opposite to the ion transmission direction, and the deflection force field is generated; thereby trapping ions within the first guide element; controlling the deflection force field generation module to work so as to enable the ions in the first guide element to generate radial deflection; and under the condition that offset is completed, the first guide element is controlled to cancel the reverse electric field so that the first guide element can move in the transmission direction, ions in the first guide element can generate radial offset through the deflection force field generation module, the ions can be more uniformly distributed in the radial direction, and therefore the space area utilization rate is increased, and the transmission efficiency is improved. And the influence of the space charge effect is reduced.

The invention relates to an ion-optical component comprising at least one electrode arrangement (12) with a circular segment-shaped inner electrode (17) and an annular segment-shaped outer electrode (18) circumferentially surrounding the inner electrode (17), as well as with two circular segment-shaped plates (23) which are surrounded on both sides of the inner electrode (17) and circumferentially by the outer electrode (18) and form a uniform annular segment-shaped gap (25) between each of the plates (23) and the outer electrode (18), wherein the ion-optical component comprises two electrode arrangements (12) which each extend over a sector with an angle ϕ / 2, where 90°<ϕ<180°, and are arranged one behind the other in such a way that a trajectory of an ion beam (14) through the ion-optical component is s-shaped.

An apparatus for ion manipulations includes an ion manipulation path extending between an inlet and an outlet, at least one continuous electrode configured to receive a first RF voltage signal, and a plurality of segmented electrodes configured to receive a second voltage signal and generate a traveling wave field based thereon. The ion manipulation path includes a first region extending in a first direction, a second region extending in a second direction, and a curved region extending between the first and second regions. The at least one continuous electrode extends through the first region, the curved region, and second region. The segmented electrodes are arranged along the ion manipulation path in the first region, the curved region, and the second region. The traveling wave field is configured to cause ions to travel through, the first region, the curved region, and the second region.