24 results about "Chemical ionization" patented technology

The invention discloses an ion molecule reaction tube with a magnetic focusing structure and an ion focusing method thereof, and belongs to the field of analysis and detection.The ion molecule reaction tube comprises an ionization source, a left ion inlet electrode, a plurality of traditional circular ring electrodes, a right ion outlet electrode, a reaction tube inner focusing magnetic pole and a reaction tube outer focusing magnetic pole; a hole is formed in the center of the focusing magnetic pole in the reaction tube, the left side surface of the hole is covered by the magnetic net, and the right side is open; a hole is formed in the center of the focusing magnetic pole outside the reaction tube, and the left and right sides are open; the left-side ion inlet electrode, the plurality of traditional circular ring electrodes and the right-side ion outlet electrode are separated by insulating sealing gaskets to form a hollow reaction tube cavity; according to the ion focusing method, focusing guide magnetic fields are formed on the left side of a focusing magnetic pole in a reaction tube and between the focusing magnetic pole and an ion outlet electrode on the right side in the reaction tube, and product ions can be gradually and efficiently focused and guided. The method has an important value for improving the detection sensitivity of the chemical ionization mass spectrometer.

The invention relates to a method for trace analytical detection and quantification of compounds of boron and / or aluminium in a gas or liquid flow containing at least one chlorosilane, comprising the steps of a) removing a sample from the gas flow and mixing with an inert gas to form a gaseous sample or removing a liquid sample from the liquid flow, wherein the liquid sample is mixed with an inert gas in an evaporator unit and evaporated to form a gaseous sample; b) transferring the gaseous sample obtained in step a) into the reaction chamber of a mass spectrometer, wherein electrons generated in an ion source by means of plasma discharge react with the chlorosilane to form chloride ion species and wherein the chloride ion species react with the compounds of boron and / or aluminum via chemical ionization to form boron and / or aluminum chloride ion species; c) separating and detecting the boron and / or aluminum chloride ion species.

The application discloses a chemical ionization mass spectrometry environment humidity correction method based on functional group classification, and comprises the following steps: establishing a humidity-mass spectrometry sensitivity dataset of different functional group species; based on the humidity-mass spectrometry sensitivity dataset, a humidity-mass spectrometry sensitivity data correction equation based on machine learning functional group classification is established; and the actual mass spectrometry sensitivity of a target species under current environmental humidity conditions is calculated according to the humidity-mass spectrometry sensitivity data correction equation. The application acquires the mass spectrometry sensitivity response characteristics of different functional group species under different environmental humidity conditions, constructs a classified humidity-mass spectrometry sensitivity data correction equation, effectively reduces the uncertainty caused by humidity changes on the mass spectrometry quantitative results of semi-volatile organic substances, improves the accuracy and stability of quantitative analysis under different humidity conditions, and solves the problem that the humidity influence is not effectively considered or only a single humidity correction method is adopted in the prior art, resulting in insufficient applicability to multiple functional group species.

The application belongs to the technical field of analysis and detection, and relates to a photochemical ionization device for mass spectrometry for real-time online detection of glyoxal in the atmosphere. The photochemical ionization device sequentially arranges a vacuum ultraviolet light source, an oxygen negative reagent ion generation zone and an ion molecule reaction zone according to the emission direction of the vacuum ultraviolet light. The oxygen negative reagent ion generation zone is a straight channel, bias electrodes, a first partial pressure electrode and a second partial pressure electrode are sequentially arranged in the wall of the straight channel according to the emission direction of the vacuum ultraviolet light, the direction of the electric field formed between the bias electrodes, the first partial pressure electrode and the second partial pressure electrode is opposite to the emission direction of the vacuum ultraviolet light, a pump is arranged between the bias electrodes and the first partial pressure electrode, an air source and a reagent auxiliary gas source are connected between the first partial pressure electrode and the second partial pressure electrode, and a gas source containing a target molecule to be detected is connected between the second partial pressure electrode and the ion molecule reaction zone. The application can effectively remove O3 generated by the vacuum ultraviolet light, thereby improving the sensitivity of glyoxal detection.

The invention relates to the technical field of semiconductor preparation, in particular to a semiconductor gaseous molecular pollutant high-coverage detection mass spectrum device and method. The device comprises a quasi-normal-pressure chemical ionization cavity, a differential transmission cavity, a low-pressure chemical ionization cavity and a mass analyzer which are sequentially connected in series, wherein vacuum difference is realized among the cavities through three ion extraction electrodes; the quasi-normal-pressure chemical ionization cavity performs chemical reaction ionization on polar components of sample gas through first reagent ions and transmits the first reagent ions and the polar components of the sample gas; the differential transmission cavity is used for efficiently transmitting the ionized sample; and the low-pressure chemical ionization cavity carries out low-pressure chemical ionization on the non-polar or weak-polar neutral sample which is not ionized through second reagent ions, and the second reagent ions are efficiently transmitted into the mass analyzer for mass spectrometric detection. According to the invention, the coupling of the quasi-normal-pressure chemical ionization source and the low-pressure chemical ionization source is realized through the multi-stage vacuum differential design, so that the non-polar or polar trace AMC compounds in the semiconductor can be detected with high sensitivity and high coverage.

Generally the embodiments of the present disclosure relate to ion identification-based mass analysis (MS), and more particularly to ionization device (100) and a related ionization device system (100S) being able to use solid reagent material (101) for reagent ion [R(101 )+ / -] formation for a chemical ionization of samples (S) being sampled. Embodiments also concern use of a selected precursor material as for example urea in solid form.

The invention relates to the technical field of mass spectrum analyzers, in particular to a mass spectrum ionization device and method for cooperatively monitoring dirt and carbon. The device comprises a high-pressure photochemical ionization cavity and a low-pressure photoelectron ionization cavity, an ion transmission module and an ion convergence reaction electrode group are arranged in the high-pressure photochemical ionization cavity; organic product ions are generated in the high-pressure photochemical ionization cavity and penetrate through a differential electrode to be transmitted into the low-pressure photoelectron ionization cavity; an electron transmission module, an ion convergence multi-pole rod group and an ion extraction electrode are arranged in the low-pressure photoelectron ionization cavity, the low-pressure photoelectron ionization cavity generates inorganic product ions, and the inorganic product ions and organic product ions penetrate through the ion extraction electrode and are transmitted to the mass analyzer for detection. Cascade connection of the two ion sources under different working air pressures is realized through vacuum difference, so that ionization detection of the two ionization sources can be obtained through single sample introduction, the analysis coverage of a mass spectrometer is greatly improved, and the application field is widened.

The application discloses a method for rapidly detecting butyric acid and isomers thereof in liquor, which does not need any pretreatment process and a large amount of organic solvents, directly takes 0.5-3ml of a liquor sample and adds the sample into a sample bottle of a rapid gas chromatography-PTR photochemical ionization source-time of flight mass spectrometer, selects appropriate rapid gas chromatography mass spectrometry conditions, and utilizes the rapid gas chromatography-PTR photochemical ionization source-time of flight mass spectrometer to rapidly complete detection of butyric acid and isomers thereof in the liquor. The method established by the application does not need any pretreatment process and a large amount of organic solvents, can rapidly detect butyric acid and isomers thereof in the liquor within five minutes, and provides a strong means for acidity and taste adjustment of the liquor.

The application discloses a radio frequency enhanced and convergent ion source for mass spectrometry, comprising a VUV light source, an ion source cavity, an auxiliary gas sampling tube, a push-pull electrode, a lamp electrode, a sample sampling tube, an enhanced reaction zone, an ion convergent zone and an ion extraction electrode. The reagent ion generation method determines the reagent ion species and purity, the molecular ion reaction efficiency and the ion transmission efficiency in the source determine the detection sensitivity of the chemical ionization source. In order to further improve the detection performance of the chemical ionization mass spectrometry, the application designs a radio frequency enhanced and convergent ion source, the reagent ions are generated by the vertical irradiation of the VUV light source, the selection of the reagent ions is facilitated and the influence of photoelectrons can be eliminated; in addition, the radio frequency enhanced reaction zone and the radio frequency ion convergent zone are introduced to improve the molecular ion reaction efficiency and the ion transmission efficiency. The application can effectively improve the detection sensitivity and the universality of the chemical ionization mass spectrometry, and has wide application prospects in the fields of atmospheric environment monitoring, industrial processes, medical diagnosis and the like.

The application discloses a quantitative method for trace gaseous nitrous acid generated by photolysis, which comprises two modes. Mode one uses a chemical ionization mass spectrometer in positive ion mode to measure the concentration change of volatile organic compounds (VOC) reacted with hydroxyl radicals (·OH) after a switch mercury lamp to quantify the ·OH concentration generated by the mercury lamp irradiation, and further makes nitric oxide (NO) react with ·OH to generate gaseous nitrous acid (HONO), so that the generated concentration of HONO is approximately equal to the change concentration of VOC measured by the mass spectrometer under the condition of NO excess. Mode two uses a NO analyzer to measure the concentration change of NO reacted with ·OH before and after the mercury lamp is turned on to quantify HONO and ·OH, and the ·OH concentration generated by the mercury lamp irradiation and the HONO concentration generated under the condition are both approximately equal to the NO concentration change measured by the NO analyzer.

The invention discloses a chemical ionization mass spectrum environment humidity correction method based on functional group classification. The method comprises the following steps: establishing humidity-mass spectrum sensitivity data sets of different functional group species; based on the humidity-mass spectrum sensitivity data set, establishing a humidity-mass spectrum sensitivity data correction equation based on machine learning functional group classification; and calculating the actual mass spectrum sensitivity of the target species under the current environment humidity condition according to the humidity-mass spectrum sensitivity data correction equation. According to the method, the mass spectrum sensitivity response characteristics of different functional group species under different environment humidity conditions are obtained, and a classified humidity-mass spectrum sensitivity data correction equation is constructed, so that the uncertainty of a semi-volatile organic compound mass spectrum quantitative result caused by humidity change is effectively reduced; the accuracy and stability of quantitative analysis under different humidity conditions are improved, and the problem that in the prior art, the humidity influence is not effectively considered or only a single humidity correction mode is adopted, so that the applicability to various functional group species is insufficient is solved.

The application relates to a radio frequency enhanced photochemical ionization source, which mainly comprises a reagent gas inlet pipe, a sample gas inlet pipe, a gas mixing area, a UVU lamp, a ring-shaped repelling electrode, a ring-shaped focusing electrode, a radio frequency hexapole and a perforated electrode for realizing vacuum difference. The VUV lamp is used as an ionization source, reagent molecules are flexibly selected according to different detection samples, and the universality is good; the collision frequency of reagent ions and sample molecules is increased at low pressure through the radio frequency hexapole, so that the probability of molecular ion reaction is increased, the transmission efficiency of ions is increased through collision focusing, the enhancement of the photochemical ionization source is realized, and the detection sensitivity of the instrument is significantly improved.

This invention discloses an online mass spectrometry analysis device and method for aerosols during the thermal runaway process of lithium-ion batteries, belonging to the field of analytical technology. The device includes a reaction chamber with a reaction cavity inside, in which the lithium-ion battery is placed; a heating jacket for heating the reaction chamber; a chemical ionization source for ionizing the gas output from the outlet pipe; and a mass spectrometer for detecting and analyzing the types and concentrations of ionized ions. A first thermometer and a second thermometer are installed inside the reaction chamber. The first thermometer monitors the temperature inside the reaction cavity, and the second thermometer monitors the temperature of the lithium-ion battery. A pressure gauge is also included to monitor the pressure inside the reaction cavity. This invention enables online, in-situ analysis of aerosols during the thermal runaway process of lithium-ion batteries, obtaining qualitative and quantitative information on a large number of components in the aerosols, solving the problem that existing spectroscopic and sensor technologies are insufficient for analyzing complex components.

The invention discloses a method for synchronously and efficiently monitoring the residual quantity of short-chain and medium-chain chlorinated paraffin in sediment, and relates to the technical field of environmental pollutant analysis. The method comprises the following steps: freeze-drying and grinding a sediment sample, mixing the sediment sample with a stable isotope internal standard, carrying out ultrasonic centrifugal extraction by adopting a dichloromethane and normal hexane mixed solution, and merging supernate; and then, purifying the extract liquor by using a straight-through EMR purification column containing Carbon S, collecting the purified liquor, carrying out nitrogen blowing concentration and solvent replacement, adding a sample introduction internal standard, and carrying out detection in a negative chemical ionization source mode by adopting gas chromatography-quadrupole time-of-flight mass spectrometry. By optimizing the pretreatment process, the dosage of the sample and the solvent is remarkably reduced, and the treatment time is shortened; by combining high-resolution mass spectrometry, the problem that the homologues of the SCCPs and the MCCPs are difficult to separate is effectively solved, synchronous, efficient and accurate quantification of the short-chain chlorinated paraffin and the medium-chain chlorinated paraffin in the sediment is realized, and the recovery rate is high.

The present invention provides a method capable of individually detecting a portion of PAHs and increasing the analysis speed, the method being a method for detecting the presence or absence of predetermined PAHs (molecular formula: M), the method comprising: a step 1 of performing chromatographic separation on a sample containing the PAHs; a step 2-1 of introducing methane gas, ionizing the PAHs by using a chemical ionization method, and generating at least one of [M + CH3] +, [M + C2H5] +, and [M + C3H5] + as a precursor ion, or a step 2-2 of introducing acetonitrile, ionizing the PAHs by using a solvent-mediated chemical ionization method, and generating at least one of [M + CH] +, [M + HNC2] +, and [M + H2NC2] + as a precursor ion; a step 3 for generating fragment ions derived from the precursor ions; and a step 4 of detecting the presence or absence of the PAHs on the basis of the presence or absence of the fragment ions.

The present disclosure relates to a multiple ion identification device, a multiple ion identification system and a method of identifying a substance. The method utilizes chemical ionization (CI) in multiple adducts formed by substances in a sampling gas of a gas sample to be analyzed in a mass spectrometer. The multiple ion identification device comprises a buffer zone to attenuate a sample flow with chemical ionization of reagents from a set of reagent ion towers (R1, R2, R3, R4, R5, R6) before the sample flow enters an ionization region (IR(A)) (IR(B)).

A vacuum ultraviolet photoionization-photochemical ionization combined ionization source comprises an ionization source cavity and a vacuum ultraviolet light source, the ionization source cavity is a hollow closed cavity, a lamp head repulsion electrode, a radio frequency coupling electrode, a photoelectron emission grid electrode, an ionization zone transmission electrode, an ionization zone ion guide electrode and an ionization zone exit grid electrode are arranged in the ionization source cavity; a circular light shielding electrode is arranged at a middle position of the ion guide zone, the light shielding electrode is a flat plate electrode, and the outer diameter of the light shielding electrode is smaller than the inner diameter of the ion through hole of the ionization zone ion guide electrode. The application realizes efficient vacuum ultraviolet photoionization and photochemical ionization based on a single VUV light source, can effectively widen the range of samples that can be detected by a photoionization mass spectrometer, improves the detection sensitivity of the instrument, and has wide application prospects in the fields of atmospheric environment detection, industrial process monitoring and high-throughput analysis of metabolites.

The invention discloses a method for rapidly detecting the blood concentration of remifentanil, which comprises the following steps: firstly, carrying out rapid and efficient pretreatment on remifentanil in a blood sample based on a liquid-liquid extraction technology, and then dripping 1-5L of supernate on sampling test paper; a micro continuous sampling ion trap mass spectrometer equipped with a thermal desorption sampler-reagent-assisted photochemical ionization source is used for detection, a sample mass spectrum can be obtained within 5 seconds, and remifentanil parent ion and fragment ion information is obtained so as to realize rapid, high-sensitivity and accurate detection of remifentanil blood concentration. The time of the whole detection process is less than 2 minutes, and the detection limit is less than 1 pg / L. The method has the advantages of simplicity and convenience in operation and rapidness in detection, and is suitable for rapid detection of the plasma concentration of remifentanil.

The invention discloses a chemical ionization device, a mass spectrometry instrument and a control method thereof, through the design of at least two stages of air pressure chambers, large-range air pressure adjustment of reaction air pressure from atmospheric pressure to a low vacuum environment is realized, and the optimal specific detection requirements of different species are met; the programmed quick switching of various reaction air pressures can be realized within a second level, so that sample analysis results with high time resolution and different reaction air pressures can be quickly obtained, and the detection efficiency and the result accuracy are greatly improved; an instrument structure does not need to be frequently adjusted or parts do not need to be replaced, various reaction conditions and sample types can be adapted, and optimal specific detection on different species can be realized by flexibly adjusting reaction air pressure; by optimizing the reaction air pressure and the electrode voltage, the chemical reaction process can be better controlled, and unnecessary side reaction and ion loss are reduced, so that the detection precision and sensitivity are improved.

The application discloses a method for chemical ionization mass spectrum analysis of offline organic aerosol samples, aiming at realizing fast and accurate measurement of polar atmospheric organic aerosol samples. The method firstly processes offline atmospheric particulate matter samples, intercepts 2-7mm-sized samples, and clamps the samples between two clean filter membranes to fix the samples; then, the samples are heated by using a nonlinear temperature program, and data are collected after heating; the thermal background signal is deducted by using a thermal background multiplication method or a thermal background inference method to ensure the accuracy of the data; finally, the mass spectrum signals of various organic components of the samples at different temperatures are analyzed by chemical ionization mass spectrum after desorption by hot nitrogen blowing, so that the molecular composition information and thermal analysis curves of the compounds in the sample aerosol are obtained. The method is simple in operation, can effectively analyze the chemical components of polar organic aerosols, is suitable for offline sample analysis of atmospheric aerosols, and has high popularization and application value.

The invention relates to a CH3 + chemical ionization formaldehyde ionizer. According to the ionizer, formaldehyde components in air sample gas are subjected to photochemical and molecular ion synergistic reaction to generate CH3 + and [CH3-CH2O] + ions through the collision effect of vacuum ultraviolet light and photoelectrons. The implementation device consists of an ionizer chamber, a molecular pump interface, a vacuum ultraviolet light source, a magnesium fluoride lens, a vacuum ultraviolet light source insulating ring, a photochemical and chemical ionization synergistic reaction tube, a reaction tube insulating ring, a reaction tube cover, a photochemical and chemical ionization synergistic reaction cavity, a gas overflow port, a sample gas feeding tube, a photoelectron grid mesh and an ion outlet. The CH3 + chemical ionization formaldehyde ionizer is combined with a mass spectrum device, the concentration of formaldehyde in a sample can be detected, and the method can be used as a real-time detection method for formaldehyde pollutants in ambient air.

At least one embodiment of this disclosure provides an ionization source control device, an ionization source control method, a mass spectrometer detection system, and a mass spectrometer detection method. The ionization source control device includes: an electrode structure, the electrode structure including a cavity, wherein the cavity includes an ion generation region and a reaction region; an ion generator configured to generate ions in the ion generation region; a voltage controller configured to apply a positive voltage or a negative voltage to the electrode structure, and switch between the positive and negative voltages to control the ions; and a sample inlet tube configured to allow the analyte flowing into the sample inlet tube to undergo a chemical ionization reaction with the controlled ions in the reaction region. This ionization source control device can rely solely on the voltage controller to apply a positive voltage or a negative voltage to the electrode structure, and switch between the positive and negative voltages to control the ions, thereby separating different ions.

The utility model provides a chemical ionization source device based on thermal desorption, and belongs to the technical field of mass spectrum devices. The device comprises a thermal desorption source, a three-axis moving platform, an analysis plate and an atmospheric pressure ion source, a through hole is formed in the three-axis moving platform, the analysis plate is placed above the three-axis moving platform, a plurality of analysis holes are formed in the analysis plate, at least one analysis hole is aligned to the through hole, a metal alloy supporting plate used for placing a sample is installed in the analysis hole, and the atmospheric pressure ion source is arranged on the metal alloy supporting plate. The thermal desorption source is arranged below the through hole and faces the metal alloy supporting plate, an input port of the atmospheric pressure ion source is provided with a transmission pipe used for inputting gas, the front end of the transmission pipe can be inserted into and cover the analysis hole, and the output end of the atmospheric pressure ion source is used for being connected with a mass spectrometer. The chemical ionization source device based on thermal desorption is simple to operate, can ionize a sample more efficiently, so that the plasma obtaining efficiency is improved, and the practicability is good.

The invention belongs to the technical field of pollutant monitoring, and relates to a particulate matter collection and thermal desorption integrated full-automatic device and application of the particulate matter collection and thermal desorption integrated full-automatic device in quantitative analysis of non-volatile components in chemical ionization time-of-flight mass spectrometer.The particulate matter collection and thermal desorption integrated full-automatic device comprises a thermal desorption sampling unit, a particulate matter collection unit and an automatic control unit; a sample collection tray in the particulate matter collection unit comprises a cylindrical cavity and a conical cavity at the bottom of the cylindrical cavity, a ring groove is formed in the top of the cylindrical cavity, and a sealing ring, a screen and a filter membrane are arranged in the ring groove; a preheating airflow pipeline and a thermal desorption sampling pipeline are arranged at the two ends of the outer side wall of the cylindrical cavity; a gas discharge pipeline is arranged at the bottom of the conical cavity; the thermal desorption sample introduction unit comprises a convex heating body, and the convex part of the convex heating body can be hermetically connected with the cylindrical cavity in the sample collection tray. According to the invention, automatic switching of a plurality of working modes such as collection, analysis and sample introduction can be realized, pretreatment is not needed, and support is provided for particle source analysis and pollution prevention and control.