2605 results about "Isotope" patented technology

A drug-loaded microparticle is applied to a medical device for subsequent application to biological tissues. A method of formulating a drug-loaded microparticle and applying it to the surface of a medical device, such as a stent, is disclosed. The drug-loaded microparticle is formulated by combining a drug with various chemical solutions. Specified sizes of the microparticles and amounts of drug(s) contained within the microparticles may be varied by altering the proportions of the chemicals/solutions. In addition to various drugs, therapeutic substances and radioactive isotopes may also be loaded into the microparticles. The drug-loaded microparticle are suspended in a polymer solution forming a polymer matrix. The polymer matrix may be applied to the entire surface or only selected portions of the medical device via dipping, spraying or combinations thereof.

During the structural analysis of a protein or peptide by tandem mass spectroscopy, a peptide ion derived from a protein that has already been measured and that is expressed in great quantities is avoided as a tandem mass spectroscopy target. A peptide derived from a minute amount of protein, which has heretofore been difficult to analyze, can be automatically determined as a tandem mass spectroscopy target within the real time of measurement. Data concerning a protein that has already been measured and a peptide derived from the protein is automatically stored in an internal database. The stored data is collated with measured data with high accuracy to determine an isotope peak. In this way, the process of selecting a peptide peak that has not been measured as the target for the next tandem analysis can be performed within the real time of measurement and a redundant measurement of peptides derived from the same protein can be avoided. The information contained in the MSⁿ spectrum is effectively utilized in each step of the MSⁿ involving a multi-stage dissociation and mass spectroscopy (MSⁿ), so that the flows for the determination of the next analysis content and the selection of the parent ion for the MSⁿ⁺¹ analysis, for example, can be optimized within the real time of measurement and with high efficiency and accuracy. Thus, a target of concern to the user can be subjected to tandem mass spectroscopy without wasteful measurement.

An implantable prosthesis, for example a stent, is provided having one or more elements that form the body structure of the prosthesis. The elements have a width that is variable from a nominal or conventional width to an increased width. The elements can have depots formed in the elements and are generally located at the increased width portions of the elements. Substances such as therapeutic substances, polymeric materials, polymeric materials containing therapeutic substances, radioactive isotopes, and radiopaque materials can be deposited into the depots.

A system and method for the production of radioisotopes by the transmutation of target isotopic material bombarded by a continuous wave particle beam. An ion source generates a continuous wave ion beam, irradiating an isotope target, which is cooled by transferring heat away from the target at heat fluxes of at least about 1 kW/cm².

A rod assembly for a fuel bundle of a nuclear reactor may include an upper end piece, lower end piece and a plurality of rod segments attached between the upper and lower end pieces and to each other so as to form an axial length of the rod assembly. The rod assembly may include an adaptor subassembly provided at given connection points for connecting adjacent rod segments or a given rod segment with one of the upper and lower end pieces. The connection points along the axial length of the rod assembly may be located where the rod assembly contacts a spacer in the fuel bundle. One (or more) of the rod segments may include an irradiation target therein for producing a desired isotope when a fuel bundle containing one (or more) rod assemblies is irradiated in a core of the reactor.

Method and apparatus for providing real-time data indicative of the isotopic composition of formation fluids during drilling. The method includes the steps of: (a) providing a reference fluid having a known isotopic composition in a reference cell; (b) capturing a sample of formation; (c) providing at least one laser beam; (e) passing a beam through the reference fluid, measuring the reference-measurement beam before and after it passes through the reference fluid; (f) and passing a beam through the sample, measuring the beam before and after it passes through the sample, and calculating a first isotope concentration from those measurements. The measurements can provide information relating to the carbon isotopic composition of individual compounds in hydrocarbon gas mixtures, with the individual compounds including methane, ethane, propane, iso- or normal butane, or iso- or normal pentane.

The invention is directed to novel compositions and methods utilizing virion derived protein nanoparticles for delivery of medical imaging agents and therapeutic agents for the diagnosis and treatment of malignant and systemic diseases. The nanoparticles of the present invention are designed to deliver radioactive isotopes suitable for imaging a tumor and its metastases. Additionally, the nanoparticles may deliver a radioisotope that is suitable for treating a tumor and its metastases by alpha, beta or gamma radiation. Alternatively, the virion derived nanoparticles may deliver a treatment agent for cancer or a combination of a radioisotope and a cancer treatment agent. Additionally the virion derived nanoparticle may include delivery of a drug that enhances the immune system's recognition of the tumor.

The invention provides a method and apparatus for preparation of radiochemicals, such as PET molecular imaging probes, wherein the reaction step or steps that couple the radioactive isotope to an organic or inorganic compound to form a positron-emitting molecular imaging probe are performed in a microfluidic environment. The method for synthesizing a radiochemical in a microfluidic environment comprises: i) providing a micro reactor comprising a first inlet port, a second inlet port, an outlet port, and at least one microchannel in fluid communication with the first and second inlet ports and the outlet port; ii) introducing a reactive precursor into the first inlet port of the micro reactor, the reactive precursor adapted for reaction with a radioactive isotope to form a radiochemical; iii) introducing a solution comprising a radioactive isotope into the second inlet port of the micro reactor; iv) contacting the reactive precursor with the isotope-containing solution in the microchannel of the micro reactor; v) reacting the reactive precursor with the isotope-containing solution as the reactive precursor and isotope-containing solution flow through the microchannel of the micro reactor, the reacting step resulting in formation of a radiochemical; and vi) collecting the radiochemical from the outlet port of the micro reactor.

One aspect of the present invention relates to a microsphere, comprising a hydrophilic polymer comprising a plurality of pendant anionic groups; a transition-metal, lanthanide or group 13-14 metal oxide, polyoxometalate or metal hydroxide or combination thereof; and a first radioisotope that emits a therapeutic β-particle. In certain embodiments, the microsphere further comprsies a second radioisotope that emits a diagnostic γ-ray; wherein the atomic number of the first radioisotope is not the same as the atomic number of the second radioisotope. In certain embodiments, the microsphere is composed of polymer impregnated with zirconia bound to ³²p as the source of the therapeutic β-emissions and ⁶⁷Ga as the source of the diagnostic γ-emissions. Another aspect of the present invention relates to the preparation of a microsphere impregnated with a radioisotope that emits therapeutic β-particles and a radioisotope that emits diagnostic β-emitting radioisotope and a γ-emitting radioistope; wherein the atomic number of the first radioisotope is not the same as the atomic number of the second radioisotope. In certain embodiments, said microspheres are administered to the patient through a catheter. In another embodiment, the microsphere is combined with the radioisotopes at the site of treatment.

A set of alloy formulations is disclosed to use with thorium based nuclear fuels in a fast spectrum reactor; with thorium based nuclear fuels in existing thermal spectrum power reactors; for medical isotope production in the epithermal, the fast, the fission spectrum and the thermal spectra; and to use as fuel in test and experimental reactors that are non proliferative. The alloys form inert metal matrixes to hold fine particles of dispersed thorium containing fuel. The formulations also are useful for the production of medical and commercial isotopes in the high energy, fast and epithermal neutron spectra.

A system and method of interpreting well log isotopic information in a drilling operation of a target area. The method begins by inputting a template for indicating a trend from analyzed mud gas samplings into a computing system. Next, a plurality of mud gas samplings are profiled through a well bore at a plurality of incremental depths of the well bore. The plurality of gas samplings are analyzed to obtain a plurality of isotopic data points associated with hydrocarbon isotopic composition of the plurality of gas samplings. The plurality of isotopic data points includes data associated with a composition of ethane and methane or other gaseous components within each of the mud gas samplings. A trend associated with the template is determined by the computing system from the plurality of isotopic data points. The plurality of isotopic data points is analyzed to geochemically interpret the geological information.

A method and apparatus for discriminating the types of radiation interacting with an integrated radiation detector having of a pulse-mode operating photosensor which is optically coupled to a gamma-ray scintillator sensor and a neutron scintillator sensor and uses an analog to digital converter (ADC) and a charge to digital converter (QDC) to determine scintillation decay times and classify radiation interactions by radiation type. The pulse processing provides for, among other things, faithful representation of the true energy spectrum of the gamma radiation field and allows for radioisotope identification by searching for the presence of characteristic energy lines in the gamma energy spectrum. The pulse shape discrimination method ensures that the high sensitivity and resolution of the isotope identification function is not affected during operation in mixed neutron-gamma fields.

The present invention relates to a method for implantation of Xe isotopes in a matrix for production of ¹²⁵I sources that do not shed radioactive atoms. ¹²⁵Xe implanted at 12 kV in steel, titanium and gold does not evolve after more than 10 half-lives (380 h) and ¹²⁵I from the decay of implanted ¹²⁵Xe is equally stable for 2 half-lives (120 d). The matrix having radioxenon implanted is useful as a medical device, for instance as a “seed” for radiotherapeutic uses or in production of stents. Methods of treatment utilizing such devices are also encompassed by the present invention.

The present invention is a power cell for directly converting ionizing radiation into electrical energy. The invented isotopic electric converter provides an electrical power source that includes an electronegative material layered in a semiconductor, to form a first region that has a high density of conduction electrons, and an electropositive material also layered in the semiconductor material to form a second region with a high density of holes. Said N-layers region and P-layers region are separated by a neutral zone of semiconductor material doped with a radioactive isotope, such as, but not limited to, tritium. No junction is formed between the N and P layers regions. Rather, the potential gradient across the neutral zone is provided by the difference between the work functions of the electronegative and electropositive electrodes. Electrical contacts are affixed to the respective regions of the first and second type conductivity which become the anode and cathode of the cell, respectively. Beta particles emitted by the tritium generate electron-hole pairs within the neutral zone, which are swept away by the potential gradient between the first and second regions, thereby producing an electric current.

There is provided a method for obtaining at least one calibration filter for a Mass Spectrometry (MS) instrument system. Measured isotope peak cluster data in a mass spectral range is obtained for a given calibration standard. Relative isotope abundances and actual mass locations of isotopes corresponding thereto are calculated for the given calibration standard. Mass spectral target peak shape functions centered within respective mass spectral ranges are specified. Convolution operations are performed between the calculated relative isotope abundances and the mass spectral target peak shape functions to form calculated isotope peak cluster data. A deconvolution operation is peformed between the measured isotope peak cluster data and the calculated isotope peak cluster data after the convolution operations to obtain the at least one calibration filter.

The invention provides reagents, kits and methods for detecting and/or quantifying proteins in complex mixtures, such as a cell lysate. The methods can be used in high throughput assays to profile cellular proteomes. In one aspect, the invention provides a peptide internal standard labeled with a stable isotope and corresponding in amino acid sequence to the amino acid sequence of a subsequence of a target polypeptide. In another aspect, the peptide internal standard is labeled at a modified amino acid residue and is used to determine the presence of, and/or quantitate the amount of a particular modified form of a protein.

The invention provides a method and apparatus for preparation of radiochemicals wherein the reaction that couples the radioactive isotope to the reactive precursor to form a positron-emitting molecular imaging probe is performed in a microfluidic environment. The method comprises: providing a micro reactor; introducing a liquid reactive precursor dissolved in a polar aprotic solvent into an inlet port of the micro reactor, the reactive precursor adapted for reaction with a radioactive isotope to form a radiochemical; introducing a solution comprising a radioactive isotope dissolved in a polar aprotic solvent into another inlet port of the micro reactor; contacting the reactive precursor with the isotope-containing solution in a microchannel of the micro reactor; reacting the reactive precursor with the isotope-containing solution as the reactive precursor and isotope-containing solution flow through the microchannel of the micro reactor, wherein the reacting step is conducted at a temperature above the boiling point of the polar aprotic solvent at 1 atm and at a pressure sufficient to maintain the polar aprotic solvent in liquid form; and collecting the resulting radiochemical from the micro reactor.