1106 results about "Reaction step" patented technology

The invention discloses a synthetic method of a water soluble ultraviolet light absorber BP-9. The method mainly comprises the following process steps: (1) carrying out methylation on the main raw materials of 2, 2', 4, 4'-tetrahydroxyl benzophenone, a transition metal salt catalyst and a mixed solvent which is prepared from dichloroethane and anhydrous ethanol in equal parts by weight to obtain 2, 2'-dihydroxyl-4, 4'-dimethoxyl benzophenone; (2) carrying out sulfonation reaction on the main raw materials of methylate, sulfamic acid and C1-C3 halohydrocarbon to obtain 2, 2'-dihydroxyl-4, 4'-dimethoxyl benzophenone-5, 5'-disulfonic acid; and (3) carrying out neutral reaction on the main raw materials of sulfonated product, inorganic base and ethanol water to finally obtain the BP-9 product. The synthetic method disclosed by the invention is few in reaction step, low in cost, high in product purity and stable in quality, and raw materials are easily available.

The invention provides a method for preparing squaric acid and a method for preparing a lithium supplement agent of lithium squarate. The method for preparing squaric acid comprises the steps of preparing an intermediate I, preparing an intermediate II and preparing squaric acid. The method for preparing the squaric acid is a novel squaric acid synthesis route, and the squaric acid is obtained through cycloaddition / substitution reaction of perchloroprene serving as an initial raw material and morpholine, hydrolysis / rearrangement reaction in a buffer system and acid hydrolysis reaction in sequence. The method for preparing squaric acid has the advantages of simple reaction steps, mild reaction conditions, high yield, low cost and the like. The invention also provides a method for preparing the lithium squarate lithium supplement agent, and the prepared squaric acid and lithium-containing alkali are blended in a solvent for reaction to generate the lithium squarate. The method for preparing the lithium squarate lithium supplement has the advantages of simple reaction steps, mild reaction conditions, high yield, low cost and the like.

The invention provides a production process for reducing the nitrogen content in reagent-grade sulfuric acid, and relates to the technical field of sulfuric acid. Comprising the following steps: adding urea solid powder into sulfuric acid at 55-65 DEG C according to the mass ratio of urea to sulfuric acid of (0.001-0.01): 100, and stirring until the urea solid powder is completely dissolved; s100, heating the mixture in the step S100 to 83-87 DEG C in a gradient manner, adding ammonium sulfate powder according to the mass ratio of ammonium sulfate to sulfuric acid of (0.05-0.1): 100 in the heating process, and stirring to react for 0.8-1.2 hours; performing reduced pressure distillation on the sulfuric acid after the reaction in the step S200 at 80-150 DEG C, introducing inert gas in a synchronous pulse manner for purging in the heating process, repeating for 2-3 times, and collecting a main fraction; treating tail gas. According to the method, the total nitrogen content and the content of NH4 < + > ions and NO3 <-> ions in the reagent-grade sulfuric acid are effectively reduced, the electronic-grade sulfuric acid is obtained, and the yield of the sulfuric acid can reach 97.5%.

The invention belongs to the field of preparation of medical intermediates, and particularly relates to a preparation method of an On-DNA sulfinic acid structure compound. The method for preparing the On-DNA sulfinic acid structure compound comprises a step of oxidizing On-DNA thiol (phenol) into the On-DNA sulfinic acid structure compound under alkaline and heating or illumination conditions, a solvent used in the reaction step is a mixed solution of water, dimethyl sulfoxide, N, N-dimethylformamide, acetonitrile, ethanol or tetrahydrofuran, the reaction temperature is not more than 80 DEG C, and the reaction time is not more than 2 hours. And the illumination wavelength ranges from 365 nanometers to 535 nanometers. The On-DNA sulfinic acid structure compound obtained in the invention can be directly used for constructing a structure compound with a sulfonyl group, the reaction condition is mild and convenient, a new method and a new idea are provided for construction of a DNA coding compound library, and the On-DNA sulfinic acid structure compound has a very good application prospect in lead drug development.

The present invention provides a method for preparing coffee diglyceride, belonging to the field of biotechnology. The present invention provides a method for preparing coffee diglyceride, comprising the following steps: 1) mixing coffee oil and glycerol, then adding a composite catalyst and choline chloride to fully mix to obtain a mixed solution; 2) subjecting the mixed solution to catalytic reaction, filtration, and molecular distillation in sequence to obtain coffee diglyceride; the catalytic reaction steps include: first vacuum catalysis, first nitrogen bubbling; second vacuum catalysis, second nitrogen bubbling, and adding a composite catalyst; third vacuum catalysis, third nitrogen bubbling; fourth vacuum catalysis, fourth nitrogen bubbling, and adding a composite catalyst; fifth vacuum catalysis, fifth nitrogen bubbling. The above preparation method is simple, low-cost, and the obtained coffee diglyceride has a high yield, high purity, and good flavor.

The invention belongs to the field of chemistry and chemical engineering, and discloses a method for preparing high-purity 1, 4-dioxane-2-ketone at low cost. A large amount of high-purity 1, 4-dioxane-2-ketone can be prepared at one time by taking a large amount of glycollic acid or glycollic acid derivatives and ethylene oxide as raw materials and adopting a one-step synthesis process route and a purification mode suitable for industrial production. According to the method, cheap bulk commodities are adopted as raw materials, and high-value conversion of low-value chemicals is achieved; according to the method disclosed by the invention, the 1, 4-dioxane-2-ketone is rapidly synthesized in one step under mild conditions without a catalyst or with a trace amount of a catalyst, so that the synthesis yield of a target product is improved, the reaction steps are greatly shortened, the energy consumption is greatly reduced, and the production cost is obviously reduced.

The invention discloses a method for efficiently synthesizing berberine hydrochloride by adopting a solid resin catalyst, and belongs to the field of medical chemical synthesis. The berberine hydrochloride can be efficiently synthesized by optimizing reaction steps and reaction conditions and adopting a solid resin catalyst for catalytic reaction. The method has relatively high reaction yield and product purity, and the catalyst can be repeatedly used, so that the environmental pollution and the production cost are effectively reduced.

The invention relates to a nitrogen-containing heterocyclic compound as well as a preparation method and application thereof, belongs to the technical field of heterocyclic compound synthesis, and solves the problems of low reaction efficiency and high energy consumption caused by the fact that an existing method for synthesizing an indole maleimide derivative needs to be carried out step by step. The preparation method comprises the following steps: step 1, adding indoleacetamide and a nucleophilic reagent into a mixed solution, and reacting; 2, performing post-treatment to obtain a nitrogen-containing heterocyclic compound; the mixed solution comprises alkali, an additive and an organic solvent; the alkali comprises one of triethylamine (Et3N), N, N-diisopropylethylamine, pyridine and 1, 8-diazabicyclo [5.4. 0] undec-7-ene, and the alkali comprises one of 1, 8-diazabicyclo [5.4. 0] undec-7-ene.

The invention relates to the field of biological medicine preparation, and provides a semi-synthesis preparation method of semeglutide and a preparation method of a semeglutide side chain, the semi-synthesis preparation method comprises the following steps: 1, in the presence of a first base catalyst, mixing a compound SMG-1 solution with a compound III solution, reacting to obtain a compound IV, and filtering to obtain a compound III; wherein the addition amount of the first base catalyst is such that the pH value of the SMG-1 solution is 11.2-11.6; 2, in the presence of a coupling agent and a second base catalyst, a compound IV solution and a compound SMG-3 solution are mixed and coupled to obtain a compound V, and the pH value in the step 2 is 9.5-10.0; and 3, carrying out deprotection on the compound V by using a deprotection agent to finally obtain the semeglutide. The method provided by the invention has the advantages of few reaction steps, reduced cost, high semeglutide purity and high yield, and is suitable for large-scale industrial production.

The invention discloses a method for preparing inositol, particularly relates to a method for converting glucose into inositol through in-vitro multi-enzyme catalysis, and belongs to the field of enzyme catalysis preparation of inositol. According to the invention, the phosphoglucose synthase capable of realizing phosphorylation of glucose by using inorganic phosphate is screened, and the inositol can be generated through conversion by taking glucose as a substrate, so that a novel method for synthesizing the inositol through enzyme catalytic conversion is provided. In addition, the invention further provides hexokinase capable of improving the yield of inositol, and the conversion efficiency of glucose is greatly improved. Furthermore, the invention provides a multi-enzyme molecular machine containing the glucose phosphate synthase and / or hexokinase, the multi-enzyme molecular machine is applied to preparation of inositol, and the reaction steps are simple, green and pollution-free.

The invention discloses a core-shell catalyst for preparing polyoxymethylene dimethyl ethers through methanol dehydrogenation and preparation and application thereof.The catalyst comprises an acidic molecular sieve, a metal active component and aluminum-containing mesoporous silica, the acidic molecular sieve serves as a core structure, the metal active component is coated on the surface of the acidic molecular sieve to form a first coating layer, and the aluminum-containing mesoporous silica serves as a second coating layer; and the aluminum-containing mesoporous silica is coated on the surface of the metal active component to form a second coating layer. According to the prepared core-shell catalyst, a middle acidic molecular sieve and aluminum-containing mesoporous silica on the outermost layer are used as acidic sites, a metal active component on the middle layer is used as a dehydrogenation site, and the two reaction sites are integrated to construct a bifunctional catalyst; in-situ coupling of two-step reaction of preparing formaldehyde through methanol dehydrogenation reaction and preparing polyoxymethylene dimethyl ether through condensation reaction of methanol and formaldehyde is realized, so that the reaction steps are simplified, and the reaction selectivity is also improved.

The invention discloses a trimethoprim hapten as well as synthesis and application thereof. The structure of the trimethoprim hapten is as shown in a formula I. The trimethoprim hapten provided by the invention can fully expose the antigenic determinant of trimethoprim and maintain the spatial conformation of trimethoprim, has good immunogenicity, and is mild in synthesis conditions, few in reaction steps, high in yield and capable of reducing the cost of raw materials. The trimethoprim colloidal gold detection product provided by the invention has the characteristics of strong specificity and high sensitivity, can realize accurate and rapid detection of trimethoprim in a sample, and has no cross reaction with other drugs. And the formula I of the # imgabs0 # is shown in the specification.

The synthesis method comprises the following steps: S1, adding furandicarboxylic acid into a reaction container, adding a certain amount of methanol, adding a double-acid-site strong acid solid catalyst, starting stirring, controlling the reaction temperature to carry out esterification reaction, and after the reaction is finished, filtering, washing and drying to obtain furandihydrazide; separating out the double-acid-site strong acid solid catalyst to obtain clear liquid, namely dimethyl furandicarboxylate; s2, transferring dimethyl furandicarboxylate serving as a raw material into another reaction container, adding a certain amount of sodium formate serving as a catalyst, then adding a proper amount of hydrazine hydrate, controlling the reaction temperature, keeping a reflux state, reacting for a period of time, cooling to room temperature after the reaction is finished, and performing centrifugal separation to obtain white solid furandihydrazide. The synthesis method has the advantages of simple reaction steps, no need of toxic and harmful catalysts, mild reaction conditions, high conversion rate and high yield, and can realize efficient, green and low-cost production of furandihydrazide.

The invention provides a preparation method and application of an asymmetric dicyclopentadienyl dialkoxy zirconium compound, and the preparation method comprises the following steps: (1) mixing a solvent with ZrCl4 and sodium cyclopentadienyl CpNa, and carrying out a reaction to obtain CpZrCl3; (2) the CpZrCl3 obtained in the step (1) and R1 substituted sodium cyclopentadienyl R1CpNa are subjected to a mixed reaction, and (R1Cp) CpZrCl2 is obtained; and (3) mixing the (R1Cp) CpZrCl2 obtained in the step (2) with alkoxy sodium salt R2Na, and carrying out a reaction so as to obtain the asymmetric dicyclopentadiene dialkoxy zirconium compound. According to the method, the substitution reaction of three sodium salts is used for replacing the ligand replacement reaction in the prior art, so that the reaction steps are shortened, the use of unnecessary raw materials is avoided, the production cost is reduced, and the obtained target product is high in yield and high in purity.

The invention provides a continuous process for preparing aromatic hydrocarbon by supercritical carbon dioxide hydrogenation, which comprises the following steps: 1) adding a reaction liquid containing a solvent and a catalyst into a reaction kettle, spraying supercritical carbon dioxide and hydrogen into a reactor by adopting a Venturi ejector, and contacting with the catalyst in the reaction kettle to react; (2) after the reaction in the step (1), the gas in the reactor is sequentially subjected to primary condensation and secondary condensation to respectively condense the solvent and the water, the solvent of the primary condensation returns to the reaction kettle, the water of the secondary condensation is discharged, and the gas after the secondary condensation sequentially passes through an absorption tower and a desorption tower to capture non-aromatic hydrocarbon, the residual gas is used as recycle gas and returns to the Venturi ejector to enter the reaction kettle; and (3) pressurizing the reaction liquid discharged from the reaction kettle after the reaction in the step (1) through a circulating pump, feeding the reaction liquid into a heat exchanger to remove reaction heat, dividing the reaction liquid subjected to heat exchange into two streams through a cross-flow filter, feeding one stream of penetrating fluid into a rectification device, and feeding the other stream of concentrated liquid back to the reaction kettle for continuous reaction.

The invention relates to a method for directly preparing (methyl) anisole from phenol and methanol, which comprises the following steps: under the action of a composite catalyst, phenol and methanol are catalyzed to generate methyl anisole, and the composite catalyst is prepared by mixing a Ho / beta molecular sieve catalyst and Ti / UiO-66 according to a mass ratio of Ho / beta: Ti / UiO-66 of 0.3-0.6: 1. According to the process, the reaction steps are simple, synthesis is achieved through one step, the total selectivity of methyl anisole reaches 76% or above, and continuous and stable operation can be conducted for 3000 h.

The invention discloses a method for preparing poly (butylene adipate-co-terephthalate) by a one-step method. The method comprises the steps of terephthalic acid esterification, adipic acid esterification, secondary esterification of terephthalic acid esterification liquid and adipic acid esterification liquid, and condensation polymerization, wherein terephthalic acid esterification and adipic acid esterification are synchronously carried out; in the terephthalic acid esterification process, a catalyst and a heat stabilizer are mixed and heated to obtain a mixed catalyst, and after terephthalic acid esterification reaction generates water, the mixed catalyst is added into a reaction system in a manner of feeding under the liquid level, so that on one hand, hydrolysis of the catalyst is reduced, and the catalytic efficiency of the catalyst is improved; on the other hand, the heat exchange efficiency is reduced and the energy consumption is increased due to the fact that a catalyst hydrolysis product covers a heat exchange pipeline; under the condition of not supplementing a catalyst, the synthesized product with qualified indexes such as PBAT melt index, color value, terminal carboxyl group and the like can be realized through subsequent secondary esterification and polycondensation.

According to the preparation method of the oral PCSK9 inhibitor intermediate, the used intermediate and the synthesis method of the intermediate, the key intermediates are innovatively designed and synthesized, the operation conditions of the steps are mild, the yield is high, the cost is low, toxic impurities are few, the steps are few, and industrial production is facilitated. The synthesis thought of the oral PCSK9 inhibitor intermediate MK-A is constructed through the key intermediates, the 5-bromo-1-pentene is innovatively used as the starting material, the reaction steps are shortened, the yield is obviously improved, the cost is reduced, and the method is suitable for large-scale production.

The invention discloses a polyurethane adhesive with a fluorine-containing side chain and a preparation method thereof, and relates to a polyurethane adhesive and a preparation method thereof. The invention aims to solve the problem that energy loss is caused by reduction of AP high-energy components due to the fact that common fluorine-containing polymers such as PVDF and PTFE are usually added in the form of an oxidizing agent due to limitation of inherent characteristics of the fluorine-containing polymers. The preparation method comprises the following steps: step 1, purging a reaction container for 30 minutes by using high-purity nitrogen, adding an initiator and a solvent, adding a catalyst A, and mixing and reacting for 10-60 minutes; step 2, dropwise adding a fluorine-containing oxetane monomer into the reaction liquid; step 3, adding branched-chain fluorine-containing hydroxyl-terminated polyether PFOH, diisocyanate and triisocyanate into the container, stirring for 5-30 minutes, adding a catalyst B, uniformly stirring, pouring into a silica gel mold, and putting into a vacuum oven at room temperature to remove bubbles; and step 4, putting the mold into a heating oven. The invention belongs to the technical field of polyurethane synthesis.

The invention discloses a spherical Prussian blue material as well as a preparation method and application thereof. The preparation method comprises the following steps: enabling a mixed reaction system containing soluble transition metal hexacyanoid salt, soluble transition metal salt, a complexing agent, soluble sodium salt, a surfactant and a carbon sphere precursor to react, and then selectively performing or not performing aging treatment to prepare the spherical Prussian blue material. According to the preparation method provided by the invention, the spherical Prussian blue material is obtained by regulating and controlling the reaction raw materials and the reaction steps, so that the rate capability and the cycle stability of the Prussian blue material are improved, and the problem that the compaction density and the compaction density are reduced due to the fact that the rate capability of a Prussian blue cube is improved due to carbon coating is solved.

The invention relates to the technical field of sodium silicate production, and particularly discloses a method for preparing sodium silicate by dissolving fluorine-containing silicon dioxide with alkali lye, which comprises the following steps: step 1, adding fluorine-containing silicon dioxide, sodium carbonate and water into a reaction kettle with a stirrer and a heating device to obtain a mixed material; 2, fully and uniformly stirring the mixed material obtained in the step 1, heating the mixed material by using a reaction kettle, and controlling the reaction temperature and the reaction time for reaction; and 3, filtering and separating the reaction product obtained in the step 2 to obtain a sodium fluoride filter cake and a sodium silicate solution. Sodium carbonate and sodium bicarbonate are used for dissolving silicon dioxide in a liquid phase reaction to prepare sodium silicate, the process is green and environment-friendly, sodium carbonate in chemical production can be effectively utilized, energy is saved, consumption is reduced, and the environment is protected. The technical problems that in the prior art, the temperature is high in the reaction process, a large amount of heat needs to be consumed, and energy consumption is high are solved.

The invention discloses a preparation method of protecting group cefdil side chain acid. The preparation method comprises the following reaction steps: step 1, performing oximation reaction on a compound IV to obtain a compound V; 2, cyclizing the compound V and thiourea to obtain a compound VI; 3, condensing the compound VI and tert-butyl alpha-bromoisobutyrate to obtain a compound VII; 4, the compound VII passes through a protective group to obtain a compound VIII; and 5, hydrolyzing the compound VIII to obtain the product protecting group cefdil side chain acid. The raw materials used in the method are simple and easy to obtain, expensive reagents and customized raw and auxiliary materials are not used, the process operation is simple, a major dangerous process is not involved, and the method has industrial advantages.

The invention relates to the field of chemical synthesis, in particular to an electrochemical synthesis method of a 4 '-N-methylbenzyl-3-indole derivative. According to the preparation method, selected electrons are traceless oxidizing agents, the energy conversion rate is high, no catalyst is needed in the reaction, the reaction steps are few, raw materials are easy to obtain, the reaction conditions are mild, operation is easy, convenient and safe, the substrate expansion range is wide, the compound functional group tolerance is high, the product yield can reach 80% or above, and the compound can be prepared in a gram level. N-methyl N-alkylaniline or N-methylaniline is used for carrying out electrochemical oxidation reaction on indole, N-methyl provides methylene to realize connection between benzene ring para-positions of the N-methyl N-alkylaniline and N-methylaniline and the C3 position of indole, and then the 3-arylmethylindole derivative is efficiently synthesized.

The invention belongs to the technical field of organic synthesis, and particularly discloses a method for preparing megastigmatrienone, and the method for preparing megastigmatrienone comprises the following steps: taking 5-bromo-1, 3-pentadiene as an initial raw material, and reacting with trivalent phosphine to prepare phosphine salt; carrying out alkali treatment to obtain a Wittig reagent, and carrying out Wittig reaction on the Wittig reagent and acetyl vinyl acetate to obtain acetate-substituted conjugated tetraene; under the co-catalysis of copper and a large-steric-hindrance ligand, carrying out a Diels-Alder reaction with isobutene to construct a six-membered ring; hydrolyzing to obtain alcohol, and oxidizing to obtain ketone; under the acidic condition, conjugated diene at the tail end is subjected to rearrangement isomerization, and megastigmatrienone is obtained; the raw materials and reagents are simple, cheap and easy to obtain, the reaction steps are short, the yield is high, separation is easy, and the method is suitable for large-scale production.

The method is for producing para-xylene using, as a main raw material, a mixed gas of carbon dioxide or carbon monoxide or both thereof and hydrogen. The method including: a reaction step of bringing a raw material mixed gas including the mixed gas into contact with a reaction catalyst under high temperature and high pressure to cause a reaction, to thereby obtain a product gas mixture containing para-xylene; a separation step of cooling the product gas mixture obtained in the reaction step to condense a high boiling point component, to thereby separate the product gas mixture into a water phase containing a water-soluble component, an oil phase containing a xylene mixture, and a gas phase containing an unreacted gas; and a circulation step of mixing at least part of the gas phase having been separated in the separation step into the raw material mixed gas.

To provide: a methane production device and a methane production method which, in production of methane gas by bio-methanation, enable supply of the methane gas at a proper concentration required on a use place where the methane gas is used; and a power generation system utilizing the methane production device.SOLUTION: A methane production method according to the present invention, which is for performing methane production based on bio-methanation, includes: a reaction step of performing a methanation reaction with hydrogen gas and biogas being supplied; and a control step of controlling the efficiency of the methanation reaction to obtain methane gas having any methane concentration. According to the methane production method, the methane gas can be supplied at a proper concentration adapted to a use place of the methane gas. A power generation system according to the present invention utilizes the methane gas obtained from a methane production device according to the present invention. The power generation system enables the methane production device to have a high efficiency without replacing an existing gas power generator.SELECTED DRAWING: Figure 1

Disclosed is a process for the synthesis of mono- and bis-nitrosylated propanediols, as well as compositions and pharmaceutical formulations that includes the compounds. The process proceeds by reacting a corresponding propanediol that is not nitrosylated with a source of nitrite, optionally in the presence of a suitable acid. When the source of nitrite is an organic nitrite, reacting step is performed in a suitable organic solvent, and when the source of nitrite is an inorganic nitrite, the reacting step is performed in a bi-phasic solvent mixture comprising an aqueous phase and a non-aqueous phase. Also disclosed are methods of treating a condition wherein administration of nitric oxide (NO) has a beneficial effect by administering said compounds, compositions or formulations.

The invention discloses a spiro-structure-based pyrrole-indolone heterocyclic derivative and a preparation method and application thereof.The spiro-structure-based pyrrole-indolone heterocyclic derivative is prepared through the steps that a cyclic imine ylide derivative (shown in the formula 1) and a 2-alkenyl indole derivative (shown in the formula 2) serve as starting raw materials and react for 6-24 h under the combined action of a catalyst, alkali and a solvent, and the spiro-structure-based pyrrole-indolone heterocyclic derivative is obtained. The pyrrole-indolone heterocyclic derivative based on the spiro structure is synthesized in one step; the preparation method has the advantages of few reaction steps, simple operation, easily available raw materials and high yield; the synthesis strategy opens up a new strategy for constructing the compound, and the stereochemical control characteristic of the product is obviously superior to that of a traditional method. The reaction system shows good tolerance to various substrate substituents (including electron donating / electron withdrawing groups), the steps of intermediate separation and purification are effectively avoided through a one-pot process, the synthesis efficiency is remarkably improved, and large-scale production feasibility is achieved.

The invention belongs to the technical field of organic synthesis, and particularly relates to a preparation method of octocrylene serving as a main component of a sun-screening agent. The invention provides a preparation method of octocrylene serving as a main component of a sun-screening agent, which comprises the following steps: dissolving benzophenone in a polar aprotic solvent, adding zinc powder, heating to 50-70 DEG C under an inert condition, and dropwise adding 2-bromo-2-ethyl cyanoacetate for reaction to obtain a solution containing an intermediate etocrylene; under an ice bath condition, acidifying the solution containing the intermediate etocrilene by using a protonic acid aqueous solution, adding isooctanol, and slowly heating to 15-30 DEG C for reaction; and after the reaction is finished, extracting, washing, drying, filtering and concentrating the reaction liquid to obtain the octocrylene. According to the preparation method, reaction steps are reduced, the preparation process is simple, the operation method is convenient and fast, high-purity octocrylene can be obtained without purifying an intermediate, and large-scale industrial production is facilitated.

The invention discloses a catalyst system and application thereof, and a production method and system of aromatic carboxylic acid. The catalyst system comprises a main catalyst containing metal ions and a co-catalyst, the metal ions comprise cobalt and manganese, and the cocatalyst is selected from hydrobromic acid and / or bromine-containing inorganic salt. When the aromatic carboxylic acid is produced, under the action of an organic acid aqueous solution and the catalyst system, aromatic hydrocarbon and oxygen-containing gas are sequentially subjected to oxidation and deep oxidation reaction, and the aromatic carboxylic acid is prepared. When the catalyst system is used for oxidation production, not only can the conversion rate of reactant aromatic hydrocarbon and the selectivity of product aromatic carboxylic acid be improved, but also a production process system of the aromatic carboxylic acid can stably run for a long time, and the catalyst system has excellent industrial application value. The aromatic carboxylic acid is produced by adopting oxidation and deep oxidation reactions in a cascade manner, the reaction conditions are mild, and the method is suitable for industrial production.