189 results about "Silicone hydrogel" patented technology

The invention provides a delamination-resistant embedded silicone hydrogel contact lens having an insert that is embedded in a silicone hydrogel bulk material. The insert is made of a crosslinked polymeric material having a refractive index higher than that of the silicone hydrogel bulk material by at least 0.07 and comprises a diffractive structure disposed on one of the front and back curve surfaces of the insert for providing a diffractive power that contributes to the overall optical power of the contact lens.

The invention discloses a side-chain type amphiphilic organosiloxane macromonomer and a preparation method and application thereof, the side-chain type amphiphilic organosiloxane macromonomer can be well mixed with various hydrophilic monomers under the condition of no hydrotropy of a solvent, and a silicon hydrogel material with high oxygen permeability and high hydrophilicity can be prepared. The invention also discloses a silicon hydrogel which is prepared from the side chain type amphiphilic organosiloxane macromonomer and the following components through polymerization reaction: 5-45 parts of side chain type organosiloxane macromonomer, 0-30 parts of micromolecular silicon monomer, 25-70 parts of hydrophilic monomer, an initiator and a cross-linking agent. The silicon hydrogel has good hydrophilic performance, high light transmittance and high oxygen permeability. Meanwhile, the invention further discloses a corneal contact lens which is made of the silicone hydrogel material and has the advantages of being good in oxygen permeability, hydrophilicity, light transmission, wearing comfort and the like.

The invention discloses high-oxygen-permeability silicone hydrogel contact lenses, which are prepared from the following raw material components in percentage by mass: 30 to 40 percent of macromolecular siloxane I, 5 to 10 percent of macromolecular siloxane II, 10 to 20 percent of micromolecular siloxane, 20 to 30 percent of hydrophilic monomers, 2 to 5 percent of humectants, 0.5 to 1.5 percent of cross-linking agents, 0.5 to 1 percent of initiators and 2 to 5 percent of functional monomers. The macromolecular siloxane I adopted by the silicone hydrogel contact lens is narrow in molecular weight distribution and good in reaction repeatability, a quaternary ammonium salt functional group is introduced into the macromolecular siloxane I, uniformity of the macromolecular siloxane in a PP mold is facilitated, and the lens has a better hydrophilic surface; meanwhile, preparation process equipment of the macromolecular siloxane I is simple, raw materials are cheap and easy to obtain, and operation is convenient; the obtained lens is high in oxygen permeation coefficient, and the lens with good surface hydrophilicity and good wetness can be obtained without surface treatment.

A silicone hydrogel contact lens formulation comprising [a] at least 40 wt% of a polymerisable siloxane, [b] at least 30 wt% of hydrophilic N-vinyl amide monomer, such as vinyl-N-methyl acetamide (VMA), N-vinyl pyrrolidone (NVP), N-vinyl formamide, or N-vinyl acetamide; [c] triphenylphosphine (TPP) and [d] 1,4-bis[(2-methacryloxyethyl)amino]-9,10-anthraquinone (RB247). The contact lens formulation can further comprise an anthraquinone blue tinting agent, a benzophenone UV-absorbing agent and / or a benzotriazole HEVL absorber to stabilise the silicone hydrogel contact lens formulation.

Provided are: a silicone hydrogel having excellent surface hydrophilicity that is stable over a long period without requiring a surface treatment, e.g., a plasma treatment, even when a hydrophobic mold, e.g., a polypropylene mold, is used; and a method for producing the silicone hydrogel. A silicone hydrogel according to one aspect of the present invention contains water. In a dried object formed by removing the water from the silicone hydrogel, the ratio of the average value (A') of O / Si concentration ratios at a first measurement point to a third measurement point to the average value (B') of O / Si concentration ratios at a fourteenth measurement point to a sixteenth measurement point, A' / B', is 1.20 or higher, the measurement points being defined separately.

A high oxygen permeability silicone hydrogel composition, contact lens made from the high oxygen permeability silicone hydrogel composition and manufacturing method of the contact lens are disclosed. The high oxygen permeability silicone hydrogel composition includes a first silicone polymer, a second silicone polymer, at least one hydrophilic monomer, a crosslinking agent, an initiator, and a solvent. By adjusting the ratio of each silicone polymer molecule and the hydrophilic monomer in the contact lens, the present invention can not only provide the contact lens with high oxygen permeability, but also expand the design scope of the silicone hydrogel contact lens.

The invention relates to the field of silicone hydrogel materials, in particular to a contact lens silicone hydrogel material with good flexibility and a preparation method thereof. The preparation method comprises the following steps: firstly, carrying out cation ring opening polymerization under 350-370 nm UV light to form a prepolymer A containing unreacted epoxy groups and vinyl; and then mixing the prepolymer A with an amido-containing hydrophilic monomer, a free radical cross-linking agent and a photothermal initiator, and carrying out second-stage polymerization under 380-410 nm UV light to form a three-dimensional network structure with an ether bond flexible interface and C-C bond strength. The method breaks through the phase separation bottleneck of traditional single-stage polymerization, the phase separation size is reduced, and the optical transparency and stability are improved. Through chemical bridging of an epoxy group and an amide group, molecular-level bonding of a siloxane phase and a water phase is realized, and flexibility and wearing comfort are improved. By introducing the flexible chain segment regulator, the flexibility of the molecular chain is enhanced, the modulus is reduced, and meanwhile, high oxygen permeability and low protein adsorbability are kept.

Silicone hydrogel contact lens formulations are described herein. The formulation has a silicone component and a silicone-free component. The silicone component comprises two or three compounds represented by a formula 1, a formula 2 or a formula 3. The silicone-free component includes a methacrylate component and an N-vinyl amide component. The methacrylate component is prepared from hydroxybutyl methacrylate (HOB) and isobornyl methacrylate (IBM). And the N-vinyl amide component is prepared from N-vinyl N-methyl acetamide. When compounds of Formula 1 and compounds of Formula 2 are present in the formulation in specific ratios relative to each other, specific amounts of HOB and IBM are provided to achieve specific ratio results in desired silicone hydrogel contact lenses. Silicone hydrogel contact lenses are also described.

Silicone hydrogel contact lens formulations are described herein. The formulation has a silicone component and a silicone-free component. The silicone component comprises two or three compounds represented by a formula 1, a formula 2 or a formula 3. The silicone-free component includes a methacrylate component and an N-vinyl amide component. The methacrylate component is prepared from hydroxybutyl methacrylate (HOB) and isobornyl methacrylate (IBM). And the N-vinyl amide component is prepared from N-vinyl N-methyl acetamide. When compounds of Formula 1 and compounds of Formula 2 are present in the formulation in specific ratios to each other, specific amounts of HOB and IBM are provided to achieve specific ratio results in desirable silicone hydrogel contact lenses. Silicone hydrogel contact lenses are also described.

The utility model discloses a silicone hydrogel contact lens demoulding machine with a batch adsorption mechanism, which comprises a demoulding control frame, a transverse movement control rail is positioned and mounted at the front end of the demoulding control frame, and the front end of the transverse movement control rail is movably connected with a lifting control frame. And a vertical movement control rail is positioned and mounted at the front end of the lifting control frame. According to the demolding machine with the batch adsorption mechanism for the silicone hydrogel contact lenses, through the action of a shock absorption damper and a shock absorption elastic piece, a limiting ring block can move on the inner side of an inner movable hole and can drive a connecting base to move at the same time, vibration of the machine in the operation process can be effectively reduced, and the service life of the machine is prolonged. And a first rubber damping ring and a second rubber damping ring can enhance the damping effect, vibration is reduced, displacement or deformation of the lens in the demolding process can be avoided, the optical performance and wearing comfort of the lens are ensured, and the qualified rate of products is increased.

A UV / HEVL filterable SiHy contact lens is described herein that not only has a relatively high UV / HEVL filterability but also has an aesthetically attractive color. Bulk siloxane hydrogels for UV / HEVL filterable SiHy contact lenses comprise repeating units of (1) at least one hydrophilic ethylene monomer, (2) at least one siloxane-containing ethylene monomer and / or at least one polysiloxane ethylene crosslinking agent, (3) at least one UV-absorbing ethylene monomer, (4) at least one crosslinking agent, and (5) at least one crosslinking agent. And (4) at least one polymerizable HEVL-absorbing compound capable of absorbing HEVL between 380 nm and 450 nm, and further comprising at least one blue colorant and at least one optical brightener distributed in the bulk siloxane hydrogel.

The present invention provides a silicone hydrogel contact lens formulation comprising a bifunctional siloxane, a hydrophilic N-vinylamide monomer, and at least 0.10% (wt / wt) triphenylphosphine (TPP); silicone hydrogel contact lenses formed by polymerizing the silicone hydrogel contact lens formulations and the use of TPP to improve the surface properties of contact lenses prepared from formulations comprising bifunctional siloxanes and hydrophilic N-vinyl amide monomers.

The present application relates to a silicone-containing composition, a silicone hydrogel obtained from the silicone-containing composition, and a contact lens comprising the silicone hydrogel. The silicone hydrogel obtained from the silicone-containing composition of the present application and a contact lens comprising the silicone hydrogel have a desired moisture content whilst having a low expansion rate during a hydration process, and thus have excellent dimensional stability and excellent oxygen permeability.

Described herein is a method for producing centrally colored silicone hydrogel contact lenses. The method comprises a step of cast molding of a lens-forming composition including a hydroxyl-containing polymerizable component to form an unprocessed silicone hydrogel contact lens having hydroxyl groups covalently incorporated into its polymer matrix and steps of applying and fixing a reactive dye to the polymer matrix only in its central circular region concentric with the central axis of the unprocessed silicone hydrogel contact lens. The obtained centrally colored silicone hydrogel contact lens has a central circular region that is only colored to selectively filter radiations of certain wavelengths, e.g., HEVL.

The present invention is related to reactive dyes each of which comprises a dichlorotriazine, chlorotriazine or vinylsulphonyl group and is capable of absorbing HEVL. They are suitable for method for producing colored silicone hydrogel contact lenses each made of a silicone hydrogel material having hydroxyl groups. The present invention is also related to a colored silicone hydrogel contact lens comprising a colored circular region in which a reactive dye is applied and thereby covalently attached.

The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.

This invention provides a soft contact lens with different functional group distributions in the inner and outer layers, and a method for manufacturing the same. [Solution] The soft contact lens includes a lens body which is a hydrogel soft contact lens or a silicone hydrogel soft contact lens. A first functional group distribution layer is formed on the outer convex surface of the lens body, and a second functional group distribution layer is formed on the first functional group distribution layer. Here, the first functional group distribution layer has a first carbon content, a first oxygen content, and a first nitrogen content, and the second functional group distribution layer has a second carbon content, a second oxygen content, and a second nitrogen content. The second oxygen content is 10% to 200% higher than the first oxygen content.

The present invention provides a silicone hydrogel contact lens formulation, comprising a polymerizable siloxane component, a hydrophilic N-vinyl amide monomer, triphenylphosphine (TPP) and one or more of anthraquinone blue tinting agent, a benzophenone UV-absorbing agent or a benzotriazole HEVL absorber; a silicone hydrogel contact lens formed from the polymerisation of the silicone hydrogel contact lens formulation; and the use of an anthraquinone blue tinting agent, a benzophenone UV-absorbing agent and / or a benzotriazole HEVL absorber to stabilise a formulation comprising a polymerizable siloxane component, a hydrophilic N-vinyl amide monomer and TPP.

The present invention generally relates to an insert for embedding in a silicone hydrogel contact lens. The insert is made of a cross-linked material that is rigid in a dry state at room temperature (from about 22°C to about 26°C), has a high oxygen permeability and a high refractive index in a fully hydrated state, and can become softer at temperatures greater than 32°C. Such a material can be used to manufacture an insert for embedding in a contact lens to correct corneal astigmatism, presbyopia, and color blindness, and to impart photochromic properties to the lens. The present invention also relates to a method for manufacturing an embedded silicone hydrogel contact lens including the insert of the present invention, and to an embedded silicone hydrogel contact lens including the insert of the present invention.

Silicone hydrogel contact lens formulations are described herein. The formulation has a silicone component and a silicone-free component. The silicone component comprises two or three compounds represented by a formula 1, a formula 2 or a formula 3. The silicone-free component includes a methacrylate component and an N-vinyl amide component. The methacrylate component is prepared from hydroxybutyl methacrylate (HOB) and isobornyl methacrylate (IBM). And the N-vinyl amide component is prepared from N-vinyl N-methyl acetamide. When compounds of Formula 1 and compounds of Formula 2 are present in the formulation in specific ratios relative to each other, specific amounts of HOB and IBM are provided to achieve specific ratio results in desired silicone hydrogel contact lenses. Silicone hydrogel contact lenses are also described.

Described herein is a method for producing centrally colored silicone hydrogel contact lenses. The method comprises a step of cast molding of a lens-forming composition including a hydroxyl-containing polymerizable component to form an unprocessed silicone hydrogel contact lens having hydroxyl groups covalently incoporated into its polymer matrix and steps of applying and fixing a reactive dye to the polymer matrix only in its central circular region concentric with the central axis of the unprocessed silicone hydrogel contact lens. The obtained centrally colored silicone hydrogel contact lens has a central circular region that is only colored to selectively filter radiations of certain wavelengths, e.g., HEVL.

The invention discloses a silicone hydrogel polymer material for contact lenses and a preparation method thereof, and relates to the field of high polymer materials. Siloxane monomers, hydrophilic monomers and a dynamic cross-linking agent are mixed to obtain a monomer mixed solution; mixing functional nanoparticles, the monomer mixed solution and an initiator to obtain a pre-polymerized solution; according to the silicon hydrogel polymer material for the contact lens, the cyclic siloxane monomer and the linear siloxane are copolymerized to form a hydrophobic micro-area with a controllable size, the oxygen permeability is optimized, a borate bond is introduced as a dynamic crosslinking point, a network is reconstructed when ocular surface inflammation occurs, and the contact lens has the advantages that the contact lens is not prone to inflammation; functional nano-particle loaded anti-inflammatory and antibacterial components are released, and the high-oxygen-permeability, intelligent anti-inflammatory and antibacterial, ultra-durable and comfortable silicon hydrogel polymer material for the contact lenses is obtained.

Disclosed is a cationic contact lens and a method for manufacturing the same. The cationic contact lens includes a polymeric lens body, which is a reaction product of a polymerizable composition that includes at least one siloxane, at least one nonionic hydrophilic monomer, and at least one non-cyclic tertiary amine monomer. The cationic contact lens can be a sterile silicone hydrogel contact lens that has not been worn. The contact lens is capable of substantially linearly releasing a releasable anionic agent and the at least one non-cyclic tertiary amine monomer facilitates uptake and / or sustained release of the releasable anionic agent by the polymeric lens body. The contact lens can be present in a sealed contact lens package. The sealed contact lens package can at least include a) a base member having a cavity; b) a contact lens encapsulation solution in the cavity; c) a sterile, unworn contact lens immersed in the contact lens encapsulation solution in the cavity, wherein the releasable anionic agent is present; and d) a cover that forms a liquid-tight seal with the base member.

In general, embodiments of the present disclosure relate to pigment containing contact lenses, such as colored contact lenses. In particular, embodiments of the present disclosure relate to a silicon hydrogel (SiHy) contact lens having a layered configuration that completely encapsulates a layer of pigment. In at least some embodiments, a method for forming a contact lens is provided. The method includes applying a clear ink to at least an iris portion of a mold and curing the clear ink with UV light to form a clear ink layer. The clear ink includes about 38 wt % to about 70 wt % of a polymer binder. The method further includes, applying, via pad printing, at least one pigmented layer onto the cured clear ink layer, and curing the at least one pigmented layer with UV light to form a lens assembly.

The present invention provides a method for producing a coated silicone hydrogel contact lens in a cost effective manner. The method comprises: obtaining a preformed silicone hydrogel contact lens, the preformed silicone hydrogel contact lens comprising a bulk silicone hydrogel material, the bulk silicone hydrogel material comprising repeating units of at least one vinyl monomer containing a carboxyl group and at least one vinyl monomer containing an aryl dihydroxy boron group; and a polymer composition comprising a water-soluble and thermally crosslinkable polymer material having an azetidinium group or an epoxy group and a polymer material having 1, 2-or 1, 2, 3, 3, 3, 3-tetrafluoropropene, heating the preformed silicone hydrogel contact lens in an aqueous coating solution of a glycol-containing hydrophilic polymer having a 1, 3-diol moiety to form a coated silicone hydrogel contact lens comprising a bulk silicone hydrogel material and a hydrogel coating, the hydrogel coating comprises a cross-linked polymeric material covalently attached to the bulk silicone hydrogel material and a grafted glycol-containing hydrophilic polymer covalently attached to the bulk silicone hydrogel material and distributed in the cross-linked polymeric material.

The invention provide a method for producing coated silicone hydrogel contact lenses in a cost-effective and environmentally friendly manner. The method is free of lens extraction step and comprises: curing thermally or actinically in a lens mold a polymerizable composition that comprises at least one hydrophilized polysiloxane vinylic crosslinker, hydroxyethyl methacrylate, C1-C2 alkoxyethyl (meth)acrylate, at least one free-radical initiator, and at least one solvent selected from the group consisting of water, propylene glycol, and / or a low-molecular weight polyethyleneglycol; and heating the cast-molded silicone hydrogel contact lens in an aqueous coating solution to form a coated silicone hydrogel contact lens comprising a bulk silicone hydrogel material and a layer of a crosslinked hydrophilic polymeric material that is covalently attached onto the bulk silicone hydrogel material. Resultant contact lenses are optically clear and wettable and have a relatively high oxygen permeability.

Described is a silicone hydrogel contact lens having non-uniform morphology. The contact lens may be made from a reactive mixture comprising: a silicone-containing component; a hydrophilic component; a non-reactive polymeric internal wetting agent; and a polymerization initiator, the contact lens having an oxygen permeability of at least about 60 barrers, and wherein the molar ratio in the lens of the polymeric non-reactive internal wetting agent to silicone, without a surface treatment, is greater in the lens's surface than in its bulk.

The invention is directed to a cast molding method for making embedded hydrogel contact lenses. The method comprises a step of actinically curing a lens-forming composition in specific locations in molding assemblies each of which is formed from one male lens mold half and one female insert mold half having a molded insert adhered thereon and comprises the lens-forming composition filling a gap between the back surface of the mold insert and the molding surface of the male lens mold half. This tack curing step ensures molded inserts adhered through multiple spots to the molding surface of each male lens mold halves which in turn will be used together with a female lens mold half in cast-molding of a lens forming composition to form an embedded silicone hydrogel contact lens.

A silicone hydrogel contact lens is described comprising an extractable amount of a hydroxyalkyl cellulose embedded in the silicone hydrogel. The presence of the hydroxyalkyl cellulose in the silicone material improves the wettability of the contact lens.

To provide a method for producing a high-purity polymer (A) and a method for inexpensively producing a silicone hydrogel lens.SOLUTION: The method for producing the polymer (A) includes (step 1) a step of polymerizing a first monomer (a) having one ethylenically unsaturated group to obtain a polymer (A1), (step 2) a step of reacting the polymer (A1) with a second monomer having an ethylenically unsaturated group to obtain a polymer (A2), and (step 3) a step of purifying the polymer (A2) using a subcritical or supercritical fluid to obtain the polymer (A). The first monomer is selected from one of a first group consisting of epoxy group-containing monomers or a second group consisting of carboxy group-containing monomers. The second monomer is selected from the other of the first group or the second group.SELECTED DRAWING: None