65 results about "Silicone hydrogel" patented technology

Silicone hydrogel contact lens formulations are described herein. The formulation has a silicone component and a silicone-free component. The silicone component comprises two or three compounds represented by a formula 1, a formula 2 or a formula 3. The silicone-free component includes a methacrylate component and an N-vinyl amide component. The methacrylate component is prepared from hydroxybutyl methacrylate (HOB) and isobornyl methacrylate (IBM). And the N-vinyl amide component is prepared from N-vinyl N-methyl acetamide. When compounds of Formula 1 and compounds of Formula 2 are present in the formulation in specific ratios relative to each other, specific amounts of HOB and IBM are provided to achieve specific ratio results in desired silicone hydrogel contact lenses. Silicone hydrogel contact lenses are also described.

Silicone hydrogel contact lens formulations are described herein. The formulation has a silicone component and a silicone-free component. The silicone component comprises two or three compounds represented by a formula 1, a formula 2 or a formula 3. The silicone-free component includes a methacrylate component and an N-vinyl amide component. The methacrylate component is prepared from hydroxybutyl methacrylate (HOB) and isobornyl methacrylate (IBM). And the N-vinyl amide component is prepared from N-vinyl N-methyl acetamide. When compounds of Formula 1 and compounds of Formula 2 are present in the formulation in specific ratios to each other, specific amounts of HOB and IBM are provided to achieve specific ratio results in desirable silicone hydrogel contact lenses. Silicone hydrogel contact lenses are also described.

The utility model discloses a silicone hydrogel contact lens demoulding machine with a batch adsorption mechanism, which comprises a demoulding control frame, a transverse movement control rail is positioned and mounted at the front end of the demoulding control frame, and the front end of the transverse movement control rail is movably connected with a lifting control frame. And a vertical movement control rail is positioned and mounted at the front end of the lifting control frame. According to the demolding machine with the batch adsorption mechanism for the silicone hydrogel contact lenses, through the action of a shock absorption damper and a shock absorption elastic piece, a limiting ring block can move on the inner side of an inner movable hole and can drive a connecting base to move at the same time, vibration of the machine in the operation process can be effectively reduced, and the service life of the machine is prolonged. And a first rubber damping ring and a second rubber damping ring can enhance the damping effect, vibration is reduced, displacement or deformation of the lens in the demolding process can be avoided, the optical performance and wearing comfort of the lens are ensured, and the qualified rate of products is increased.

A UV / HEVL filterable SiHy contact lens is described herein that not only has a relatively high UV / HEVL filterability but also has an aesthetically attractive color. Bulk siloxane hydrogels for UV / HEVL filterable SiHy contact lenses comprise repeating units of (1) at least one hydrophilic ethylene monomer, (2) at least one siloxane-containing ethylene monomer and / or at least one polysiloxane ethylene crosslinking agent, (3) at least one UV-absorbing ethylene monomer, (4) at least one crosslinking agent, and (5) at least one crosslinking agent. And (4) at least one polymerizable HEVL-absorbing compound capable of absorbing HEVL between 380 nm and 450 nm, and further comprising at least one blue colorant and at least one optical brightener distributed in the bulk siloxane hydrogel.

This invention provides a soft contact lens with different functional group distributions in the inner and outer layers, and a method for manufacturing the same. [Solution] The soft contact lens includes a lens body which is a hydrogel soft contact lens or a silicone hydrogel soft contact lens. A first functional group distribution layer is formed on the outer convex surface of the lens body, and a second functional group distribution layer is formed on the first functional group distribution layer. Here, the first functional group distribution layer has a first carbon content, a first oxygen content, and a first nitrogen content, and the second functional group distribution layer has a second carbon content, a second oxygen content, and a second nitrogen content. The second oxygen content is 10% to 200% higher than the first oxygen content.

The present invention provides a silicone hydrogel contact lens formulation, comprising a polymerizable siloxane component, a hydrophilic N-vinyl amide monomer, triphenylphosphine (TPP) and one or more of anthraquinone blue tinting agent, a benzophenone UV-absorbing agent or a benzotriazole HEVL absorber; a silicone hydrogel contact lens formed from the polymerisation of the silicone hydrogel contact lens formulation; and the use of an anthraquinone blue tinting agent, a benzophenone UV-absorbing agent and / or a benzotriazole HEVL absorber to stabilise a formulation comprising a polymerizable siloxane component, a hydrophilic N-vinyl amide monomer and TPP.

Silicone hydrogel contact lens formulations are described herein. The formulation has a silicone component and a silicone-free component. The silicone component comprises two or three compounds represented by a formula 1, a formula 2 or a formula 3. The silicone-free component includes a methacrylate component and an N-vinyl amide component. The methacrylate component is prepared from hydroxybutyl methacrylate (HOB) and isobornyl methacrylate (IBM). And the N-vinyl amide component is prepared from N-vinyl N-methyl acetamide. When compounds of Formula 1 and compounds of Formula 2 are present in the formulation in specific ratios relative to each other, specific amounts of HOB and IBM are provided to achieve specific ratio results in desired silicone hydrogel contact lenses. Silicone hydrogel contact lenses are also described.

In general, embodiments of the present disclosure relate to pigment containing contact lenses, such as colored contact lenses. In particular, embodiments of the present disclosure relate to a silicon hydrogel (SiHy) contact lens having a layered configuration that completely encapsulates a layer of pigment. In at least some embodiments, a method for forming a contact lens is provided. The method includes applying a clear ink to at least an iris portion of a mold and curing the clear ink with UV light to form a clear ink layer. The clear ink includes about 38 wt % to about 70 wt % of a polymer binder. The method further includes, applying, via pad printing, at least one pigmented layer onto the cured clear ink layer, and curing the at least one pigmented layer with UV light to form a lens assembly.

The present invention provides a method for producing a coated silicone hydrogel contact lens in a cost effective manner. The method comprises: obtaining a preformed silicone hydrogel contact lens, the preformed silicone hydrogel contact lens comprising a bulk silicone hydrogel material, the bulk silicone hydrogel material comprising repeating units of at least one vinyl monomer containing a carboxyl group and at least one vinyl monomer containing an aryl dihydroxy boron group; and a polymer composition comprising a water-soluble and thermally crosslinkable polymer material having an azetidinium group or an epoxy group and a polymer material having 1, 2-or 1, 2, 3, 3, 3, 3-tetrafluoropropene, heating the preformed silicone hydrogel contact lens in an aqueous coating solution of a glycol-containing hydrophilic polymer having a 1, 3-diol moiety to form a coated silicone hydrogel contact lens comprising a bulk silicone hydrogel material and a hydrogel coating, the hydrogel coating comprises a cross-linked polymeric material covalently attached to the bulk silicone hydrogel material and a grafted glycol-containing hydrophilic polymer covalently attached to the bulk silicone hydrogel material and distributed in the cross-linked polymeric material.

The invention is directed to a cast molding method for making embedded hydrogel contact lenses. The method comprises a step of actinically curing a lens-forming composition in specific locations in molding assemblies each of which is formed from one male lens mold half and one female insert mold half having a molded insert adhered thereon and comprises the lens-forming composition filling a gap between the back surface of the mold insert and the molding surface of the male lens mold half. This tack curing step ensures molded inserts adhered through multiple spots to the molding surface of each male lens mold halves which in turn will be used together with a female lens mold half in cast-molding of a lens forming composition to form an embedded silicone hydrogel contact lens.

A silicone hydrogel contact lens is described comprising an extractable amount of a hydroxyalkyl cellulose embedded in the silicone hydrogel. The presence of the hydroxyalkyl cellulose in the silicone material improves the wettability of the contact lens.

To provide a method for producing a high-purity polymer (A) and a method for inexpensively producing a silicone hydrogel lens.SOLUTION: The method for producing the polymer (A) includes (step 1) a step of polymerizing a first monomer (a) having one ethylenically unsaturated group to obtain a polymer (A1), (step 2) a step of reacting the polymer (A1) with a second monomer having an ethylenically unsaturated group to obtain a polymer (A2), and (step 3) a step of purifying the polymer (A2) using a subcritical or supercritical fluid to obtain the polymer (A). The first monomer is selected from one of a first group consisting of epoxy group-containing monomers or a second group consisting of carboxy group-containing monomers. The second monomer is selected from the other of the first group or the second group.SELECTED DRAWING: None

The invention relates to a corneal contact lens and a preparation method thereof, the corneal contact lens comprises a contact lens body and a plurality of degradable microneedles, the plurality of degradable microneedles are arranged on the contact lens body, the preparation method comprises the following steps: preparing a female die, pouring a polydimethylsiloxane prepolymerization liquid and a curing agent into the female die, and forming a preliminary die after molding; a silicon hydrogel prepolymerization solution is injected into a contact lens cavity, a material corresponding to an outer layer is injected into a microneedle cavity, then a material corresponding to an inner layer is injected, finally a substrate material is injected, after curing, the two materials of the outer layer and the inner layer form molecular-level physical embedding on an interface so as to form a microneedle main body, and the microneedle main body is directly fixed on a silicon hydrogel substrate; stripping from the mold to obtain the corneal contact lens; the extracted exosome is loaded to the inner layer and the outer layer in a double-layer partition loading mode. According to the cornea contact lens and the preparation method, the treatment cycle can be remarkably shortened, the medical cost is reduced, meanwhile, repeated medical treatment and operation risks are avoided, and the cornea contact lens makes close contact with the cornea, is not prone to displacement or falling off and is good in permeation effect.

Batches of a thermally-curable, silicone hydrogel, contact lens formulation having a mass of at least 1 kg and a dynamic viscosity of greater than 15 CP at 25 o c comprising a thermally-activated radi

The invention relates generally to a silicone hydrogel-embedded contact lens comprising a silicone hydrogel material and a hydrophobic insert. The silicone hydrogel material comprises repeating units of at least one polysiloxane vinyl crosslinking prime comprising hydrophilized siloxane units, each having a methyl substituent and an organic radical including at least one hydrogen bond donor (e.g., hydroxyl groups), wherein the content of said at least one hydrogen bond donor is at least 0.8 meq / g relative to the molecular weight of said at least one polysiloxane vinyl crosslinking prime. The hydrophobic insert is composed of a crosslinked polymeric material comprising at least 40 mol% acrylic repeating units and at least 6 mol% repeating units of at least one vinyl crosslinking agent. The embedded silicone hydrogel is not prone to delamination.

The present application relates to a kind of high ductility silicon hydrogel, which is prepared by polymerization reaction of polymerizable composition containing thiol with functionality greater than or equal to 3, and the elongation of the high ductility silicon hydrogel is 285%-439%.The present application also relates to a kind of high ductility contact lens and its preparation method.By adding thiol with functionality greater than or equal to 3 as crosslinking agent in the formula of silicon hydrogel, the formed silicon hydrogel polymer network is more regular, more full and more stretchy, so that the prepared contact lens has good ductility, and the contact lens has high water content and low modulus.In addition, compared with the contact lens formed without adding thiol with functionality greater than or equal to 3, the size change of the contact lens formed after adding thiol with functionality greater than or equal to 3 is less than 5%.

The invention relates to the field of organic silicon materials, and particularly discloses a polyether modified silicone oil cross-linking agent as well as a preparation method and application thereof. The structural general formula of the polyether modified silicone oil cross-linking agent is shown in the specification, wherein the structural formula of R1 and the structural formula of R3 are-CH2-or-CH2-CH2-CH2-O-; the structural formulas of R1, R2 and R4 are one of-H, C1-C10 and the like; the structural formula of R5 is shown in the specification; the structural formula of R6 is shown in the specification; the value range of a is an integer between 0 and 60, the value range of b is an integer between 1 and 12, and the value range of c is an integer between 1 and 40. According to the polyether modified silicone oil cross-linking agent, the compatibility of an organic silicon monomer and a hydrophilic monomer can be greatly improved, so that the prepared material has relatively high mechanical strength, and the requirements of xerophthalmia patients and people wearing contact lenses for a long time can be met in the aspects of comfort and safety; particularly, the preparation method has a good application prospect in the field of preparation of silicone hydrogel lenses.

The present invention provides a class of high RI polysiloxane vinylic crosslinkers. The polysiloxane vinylic crosslinkers of the invention each comprise (1) a polysiloxane segment comprising dimethylsiloxane units and aryl-containing siloxane units each having one methyl substituent and one organic substituent having up to 45 carbon atoms and at least one aryl moiety connected to the Si atom through a linking group having at least 2 (preferably 3) carbon atoms; and (2) an ethylenically unsaturated group. The invention also provides an insert or a silicone hydrogel contact lens comprising a crosslinked polymeric material comprising repeat units of at least one of such high RI polysiloxane vinylic crosslinkers.

The invention provides a silicone hydrogel contact lens formulation comprising a difunctional siloxane, a hydrophilic N-vinyl amide monomer, and at least 0.10% (wt / wt) triphenylphosphine (TPP); a silicone hydrogel contact lens formed by polymerizing the silicone hydrogel contact lens formulation, and the use of TPP to improve the surface properties of a contact lens prepared from a formulation comprising a difunctional siloxane and a hydrophilic N-vinyl amide monomer.

The invention discloses a silicon hydrogel material as well as a preparation method and application thereof. The preparation method comprises the following steps: curing and molding 2-hydroxyethyl methacrylate (HEMA), 3-(trimethylsiloxy) propyl methacrylate (TRIS), ethylene glycol dimethacrylate (EGDMA), a silane coupling agent and a photoinitiator through a photopolymerization reaction to obtain a silicon hydrogel substrate; performing oxygen plasma treatment; preparing a PDMS hydrophobic layer; performing oxygen plasma treatment; soaking in an organic solution containing a hydrophobic initiator; and forming a hydrophilic polymer layer. The high oxygen permeability, long-acting moisture retention, low friction and protein deposition resistance of the lens are realized by constructing a'hydrophobic water locking-hydrophilic lubrication 'double-layer functional interface.

Provided are a silicone hydrogel that has, even when being produced using a hydrophobic mold such as a polypropylene mold, excellent surface hydrophilicity that is stable for a long period of time without requiring a surface treatment such as a plasma treatment, and a method for producing the same. The silicone hydrogel according to one embodiment of the present invention contains water, and in a dried body produced by removing water from the silicone hydrogel, a ratio (A′ / B′) of an average value (A′) of O / Si concentration ratios at a first measurement point to a third measurement point to an average value (B′) of O / Si concentration ratios at a 14th measurement point to a 16th measurement point, which are separately defined, is 1.20 or more.

The invention provides a method for producing coated silicone hydrogel contact lenses in a cost-effective manner. The method comprises treating the molding surfaces of polypropylene lens molds (or other hydrophobic plastic molds) with a vacuum UV or a corona plasma to increase the surface energies of the molding surfaces of the lens molds, cast-molding a silicone hydrogel lens formulation containing a relatively small amount of at least one carboxyl-containing vinylic monomer in the treated lens molds, and heating resultant cast-molded silicone hydrogel contact lenses in an aqueous coating solution comprising a water-soluble and thermally crosslinkable polymeric material to form a coated silicone hydrogel contact lens comprising a bulk silicone hydrogel material and a hydrogel layer covalently attached onto the bulk silicone hydrogel material.

The invention relates generally to an insert intended to be embedded in a silicone hydrogel contact lens. The insert is made of crosslinked materials that are rigid in the dry state at room temperature (approximately 22°C to approximately 26°C), have high oxygen permeability and a high refractive index in the fully hydrated state, and can be softened at temperatures above 32°C. Such materials are useful in the manufacture of embedded contact lens inserts for correcting corneal astigmatism, presbyopia, and color blindness, and for imparting photochromic characteristics to the lenses. The invention also relates to a method for manufacturing embedded silicone hydrogel contact lenses comprising an insert of the invention, and embedded silicone hydrogel contact lenses comprising an insert of the invention.

Batches of a thermally-curable, silicone hydrogel, contact lens formulation having a mass of at least 1 kg and a dynamic viscosity of greater than 15 CP at 25 o c comprising a thermally-activated radi

The present invention provides a silicone hydrogel mixture and a wettable silicone hydrogel lens formed therefrom. The silicone hydrogel mixture comprises a polysiloxane macromolecule, a hydrophilic polymer, and a hydrophilic non-polysiloxane cross-linking agent, wherein the hydrophilic non-polysiloxane cross-linking agent is polyethylene glycol dimethacrylate (PEGDMA) having the following structural formula represented by formula (A): wherein R1 and R2 are CH3, or R1 and R2 are H, and n is an integer from 4 to 42.

The invention provides a delamination-resistant embedded silicone hydrogel contact lens having an insert that is embedded in a silicone hydrogel bulk material. The insert is made of a crosslinked polymeric material having a refractive index higher than that of the silicone hydrogel bulk material by at least 0.07 and comprises a diffractive structure disposed on one of the front and back curve surfaces of the insert for providing a diffractive power that contributes to the overall optical power of the contact lens.

A silicone hydrogel ink binder includes (a) one or more colorants, (b) a solvent, and (c) a silicone copolymer including a reaction product of (i) a copolymerization product of a polymerization composition comprising (1) an alkylacrylamide monomer, (2) a hydroxyethyl acrylate monomer, (3) a non-bulky organosilicon-containing monomer having an ethylenically unsaturated reactive end group, and (4) a bulky siloxane monomer having an ethylenically unsaturated reactive end group, with (ii) a monomer having a reactive functionality complementary to the hydroxyl moiety of the hydroxyethyl acrylate monomer and a polymerizable ethylenically unsaturated reactive end group.

The present application relates to a silicone hydrogel prepared by polymerization of a polymerizable composition. The polymerizable composition comprises the following components: (a) a monofunctional siloxane monomer; (b) a hydrophilic N-vinyl amide monomer; (c) a hydrophobic vinyl monomer; (d) a hydrophilic vinyl monomer containing a hydroxyl group; (e) a non-silicone type vinyl crosslinker; and (f) a free radical initiator. The hydrophobic vinyl monomer has a refractive index greater than 1.41, and the hydrophobic vinyl monomer has a glass transition temperature greater than or equal to 60°C. The present application also relates to a contact lens prepared from the above silicone hydrogel and a method for preparing the same. The contact lens described herein has a release rate of up to 100%, and a dry sheet modulus preferably greater than 100 MPa.

A monofunctional urea-based organosilicon monomer represented by a structure of Formula (I) wherein R, R1, R2, R3, R4, R5, R6, R7, R8, m and n are as defined herein. An ophthalmic device having optical clarity is a polymerization product of a monomeric mixture including (a) one or more monofunctional urea-based organosilicon monomers represented by a structure of Formula (I), and (b) one or more ophthalmic device-forming hydrophilic comonomers or polymers.

A beneficial agent-releasing silicone hydrogel contact lens that is capable of taking up and sustaining the release of a releasable beneficial agent and methods of making the contact lens. The contact lens comprises a charged hydrophobic molecule that is embedded in and non-covalently bound to a polymer matrix of a polymeric lens body of the contact lens. A releasable beneficial agent may be complexed to the polymeric lens body via ionic interactions between the beneficial agent and the charged hydrophobic molecule. The charged hydrophobic molecule advantageously facilitates controlled release of the releasable beneficial agent by the polymeric lens body, e.g. during wear.