94 results about "Silicone hydrogel" patented technology

The invention relates to the field of silicone hydrogel materials, in particular to a contact lens silicone hydrogel material with good flexibility and a preparation method thereof. The preparation method comprises the following steps: firstly, carrying out cation ring opening polymerization under 350-370 nm UV light to form a prepolymer A containing unreacted epoxy groups and vinyl; and then mixing the prepolymer A with an amido-containing hydrophilic monomer, a free radical cross-linking agent and a photothermal initiator, and carrying out second-stage polymerization under 380-410 nm UV light to form a three-dimensional network structure with an ether bond flexible interface and C-C bond strength. The method breaks through the phase separation bottleneck of traditional single-stage polymerization, the phase separation size is reduced, and the optical transparency and stability are improved. Through chemical bridging of an epoxy group and an amide group, molecular-level bonding of a siloxane phase and a water phase is realized, and flexibility and wearing comfort are improved. By introducing the flexible chain segment regulator, the flexibility of the molecular chain is enhanced, the modulus is reduced, and meanwhile, high oxygen permeability and low protein adsorbability are kept.

Silicone hydrogel contact lens formulations are described herein. The formulation has a silicone component and a silicone-free component. The silicone component comprises two or three compounds represented by a formula 1, a formula 2 or a formula 3. The silicone-free component includes a methacrylate component and an N-vinyl amide component. The methacrylate component is prepared from hydroxybutyl methacrylate (HOB) and isobornyl methacrylate (IBM). And the N-vinyl amide component is prepared from N-vinyl N-methyl acetamide. When compounds of Formula 1 and compounds of Formula 2 are present in the formulation in specific ratios relative to each other, specific amounts of HOB and IBM are provided to achieve specific ratio results in desired silicone hydrogel contact lenses. Silicone hydrogel contact lenses are also described.

Silicone hydrogel contact lens formulations are described herein. The formulation has a silicone component and a silicone-free component. The silicone component comprises two or three compounds represented by a formula 1, a formula 2 or a formula 3. The silicone-free component includes a methacrylate component and an N-vinyl amide component. The methacrylate component is prepared from hydroxybutyl methacrylate (HOB) and isobornyl methacrylate (IBM). And the N-vinyl amide component is prepared from N-vinyl N-methyl acetamide. When compounds of Formula 1 and compounds of Formula 2 are present in the formulation in specific ratios to each other, specific amounts of HOB and IBM are provided to achieve specific ratio results in desirable silicone hydrogel contact lenses. Silicone hydrogel contact lenses are also described.

The utility model discloses a silicone hydrogel contact lens demoulding machine with a batch adsorption mechanism, which comprises a demoulding control frame, a transverse movement control rail is positioned and mounted at the front end of the demoulding control frame, and the front end of the transverse movement control rail is movably connected with a lifting control frame. And a vertical movement control rail is positioned and mounted at the front end of the lifting control frame. According to the demolding machine with the batch adsorption mechanism for the silicone hydrogel contact lenses, through the action of a shock absorption damper and a shock absorption elastic piece, a limiting ring block can move on the inner side of an inner movable hole and can drive a connecting base to move at the same time, vibration of the machine in the operation process can be effectively reduced, and the service life of the machine is prolonged. And a first rubber damping ring and a second rubber damping ring can enhance the damping effect, vibration is reduced, displacement or deformation of the lens in the demolding process can be avoided, the optical performance and wearing comfort of the lens are ensured, and the qualified rate of products is increased.

A UV / HEVL filterable SiHy contact lens is described herein that not only has a relatively high UV / HEVL filterability but also has an aesthetically attractive color. Bulk siloxane hydrogels for UV / HEVL filterable SiHy contact lenses comprise repeating units of (1) at least one hydrophilic ethylene monomer, (2) at least one siloxane-containing ethylene monomer and / or at least one polysiloxane ethylene crosslinking agent, (3) at least one UV-absorbing ethylene monomer, (4) at least one crosslinking agent, and (5) at least one crosslinking agent. And (4) at least one polymerizable HEVL-absorbing compound capable of absorbing HEVL between 380 nm and 450 nm, and further comprising at least one blue colorant and at least one optical brightener distributed in the bulk siloxane hydrogel.

Described herein is a method for producing centrally colored silicone hydrogel contact lenses. The method comprises a step of cast molding of a lens-forming composition including a hydroxyl-containing polymerizable component to form an unprocessed silicone hydrogel contact lens having hydroxyl groups covalently incorporated into its polymer matrix and steps of applying and fixing a reactive dye to the polymer matrix only in its central circular region concentric with the central axis of the unprocessed silicone hydrogel contact lens. The obtained centrally colored silicone hydrogel contact lens has a central circular region that is only colored to selectively filter radiations of certain wavelengths, e.g., HEVL.

The present invention is related to reactive dyes each of which comprises a dichlorotriazine, chlorotriazine or vinylsulphonyl group and is capable of absorbing HEVL. They are suitable for method for producing colored silicone hydrogel contact lenses each made of a silicone hydrogel material having hydroxyl groups. The present invention is also related to a colored silicone hydrogel contact lens comprising a colored circular region in which a reactive dye is applied and thereby covalently attached.

This invention provides a soft contact lens with different functional group distributions in the inner and outer layers, and a method for manufacturing the same. [Solution] The soft contact lens includes a lens body which is a hydrogel soft contact lens or a silicone hydrogel soft contact lens. A first functional group distribution layer is formed on the outer convex surface of the lens body, and a second functional group distribution layer is formed on the first functional group distribution layer. Here, the first functional group distribution layer has a first carbon content, a first oxygen content, and a first nitrogen content, and the second functional group distribution layer has a second carbon content, a second oxygen content, and a second nitrogen content. The second oxygen content is 10% to 200% higher than the first oxygen content.

The present invention provides a silicone hydrogel contact lens formulation, comprising a polymerizable siloxane component, a hydrophilic N-vinyl amide monomer, triphenylphosphine (TPP) and one or more of anthraquinone blue tinting agent, a benzophenone UV-absorbing agent or a benzotriazole HEVL absorber; a silicone hydrogel contact lens formed from the polymerisation of the silicone hydrogel contact lens formulation; and the use of an anthraquinone blue tinting agent, a benzophenone UV-absorbing agent and / or a benzotriazole HEVL absorber to stabilise a formulation comprising a polymerizable siloxane component, a hydrophilic N-vinyl amide monomer and TPP.

The present invention generally relates to an insert for embedding in a silicone hydrogel contact lens. The insert is made of a cross-linked material that is rigid in a dry state at room temperature (from about 22°C to about 26°C), has a high oxygen permeability and a high refractive index in a fully hydrated state, and can become softer at temperatures greater than 32°C. Such a material can be used to manufacture an insert for embedding in a contact lens to correct corneal astigmatism, presbyopia, and color blindness, and to impart photochromic properties to the lens. The present invention also relates to a method for manufacturing an embedded silicone hydrogel contact lens including the insert of the present invention, and to an embedded silicone hydrogel contact lens including the insert of the present invention.

Silicone hydrogel contact lens formulations are described herein. The formulation has a silicone component and a silicone-free component. The silicone component comprises two or three compounds represented by a formula 1, a formula 2 or a formula 3. The silicone-free component includes a methacrylate component and an N-vinyl amide component. The methacrylate component is prepared from hydroxybutyl methacrylate (HOB) and isobornyl methacrylate (IBM). And the N-vinyl amide component is prepared from N-vinyl N-methyl acetamide. When compounds of Formula 1 and compounds of Formula 2 are present in the formulation in specific ratios relative to each other, specific amounts of HOB and IBM are provided to achieve specific ratio results in desired silicone hydrogel contact lenses. Silicone hydrogel contact lenses are also described.

Described herein is a method for producing centrally colored silicone hydrogel contact lenses. The method comprises a step of cast molding of a lens-forming composition including a hydroxyl-containing polymerizable component to form an unprocessed silicone hydrogel contact lens having hydroxyl groups covalently incoporated into its polymer matrix and steps of applying and fixing a reactive dye to the polymer matrix only in its central circular region concentric with the central axis of the unprocessed silicone hydrogel contact lens. The obtained centrally colored silicone hydrogel contact lens has a central circular region that is only colored to selectively filter radiations of certain wavelengths, e.g., HEVL.

The invention discloses a silicone hydrogel polymer material for contact lenses and a preparation method thereof, and relates to the field of high polymer materials. Siloxane monomers, hydrophilic monomers and a dynamic cross-linking agent are mixed to obtain a monomer mixed solution; mixing functional nanoparticles, the monomer mixed solution and an initiator to obtain a pre-polymerized solution; according to the silicon hydrogel polymer material for the contact lens, the cyclic siloxane monomer and the linear siloxane are copolymerized to form a hydrophobic micro-area with a controllable size, the oxygen permeability is optimized, a borate bond is introduced as a dynamic crosslinking point, a network is reconstructed when ocular surface inflammation occurs, and the contact lens has the advantages that the contact lens is not prone to inflammation; functional nano-particle loaded anti-inflammatory and antibacterial components are released, and the high-oxygen-permeability, intelligent anti-inflammatory and antibacterial, ultra-durable and comfortable silicon hydrogel polymer material for the contact lenses is obtained.

In general, embodiments of the present disclosure relate to pigment containing contact lenses, such as colored contact lenses. In particular, embodiments of the present disclosure relate to a silicon hydrogel (SiHy) contact lens having a layered configuration that completely encapsulates a layer of pigment. In at least some embodiments, a method for forming a contact lens is provided. The method includes applying a clear ink to at least an iris portion of a mold and curing the clear ink with UV light to form a clear ink layer. The clear ink includes about 38 wt % to about 70 wt % of a polymer binder. The method further includes, applying, via pad printing, at least one pigmented layer onto the cured clear ink layer, and curing the at least one pigmented layer with UV light to form a lens assembly.

The present invention provides a method for producing a coated silicone hydrogel contact lens in a cost effective manner. The method comprises: obtaining a preformed silicone hydrogel contact lens, the preformed silicone hydrogel contact lens comprising a bulk silicone hydrogel material, the bulk silicone hydrogel material comprising repeating units of at least one vinyl monomer containing a carboxyl group and at least one vinyl monomer containing an aryl dihydroxy boron group; and a polymer composition comprising a water-soluble and thermally crosslinkable polymer material having an azetidinium group or an epoxy group and a polymer material having 1, 2-or 1, 2, 3, 3, 3, 3-tetrafluoropropene, heating the preformed silicone hydrogel contact lens in an aqueous coating solution of a glycol-containing hydrophilic polymer having a 1, 3-diol moiety to form a coated silicone hydrogel contact lens comprising a bulk silicone hydrogel material and a hydrogel coating, the hydrogel coating comprises a cross-linked polymeric material covalently attached to the bulk silicone hydrogel material and a grafted glycol-containing hydrophilic polymer covalently attached to the bulk silicone hydrogel material and distributed in the cross-linked polymeric material.

The invention provide a method for producing coated silicone hydrogel contact lenses in a cost-effective and environmentally friendly manner. The method is free of lens extraction step and comprises: curing thermally or actinically in a lens mold a polymerizable composition that comprises at least one hydrophilized polysiloxane vinylic crosslinker, hydroxyethyl methacrylate, C1-C2 alkoxyethyl (meth)acrylate, at least one free-radical initiator, and at least one solvent selected from the group consisting of water, propylene glycol, and / or a low-molecular weight polyethyleneglycol; and heating the cast-molded silicone hydrogel contact lens in an aqueous coating solution to form a coated silicone hydrogel contact lens comprising a bulk silicone hydrogel material and a layer of a crosslinked hydrophilic polymeric material that is covalently attached onto the bulk silicone hydrogel material. Resultant contact lenses are optically clear and wettable and have a relatively high oxygen permeability.

The invention is directed to a cast molding method for making embedded hydrogel contact lenses. The method comprises a step of actinically curing a lens-forming composition in specific locations in molding assemblies each of which is formed from one male lens mold half and one female insert mold half having a molded insert adhered thereon and comprises the lens-forming composition filling a gap between the back surface of the mold insert and the molding surface of the male lens mold half. This tack curing step ensures molded inserts adhered through multiple spots to the molding surface of each male lens mold halves which in turn will be used together with a female lens mold half in cast-molding of a lens forming composition to form an embedded silicone hydrogel contact lens.

A silicone hydrogel contact lens is described comprising an extractable amount of a hydroxyalkyl cellulose embedded in the silicone hydrogel. The presence of the hydroxyalkyl cellulose in the silicone material improves the wettability of the contact lens.

To provide a method for producing a high-purity polymer (A) and a method for inexpensively producing a silicone hydrogel lens.SOLUTION: The method for producing the polymer (A) includes (step 1) a step of polymerizing a first monomer (a) having one ethylenically unsaturated group to obtain a polymer (A1), (step 2) a step of reacting the polymer (A1) with a second monomer having an ethylenically unsaturated group to obtain a polymer (A2), and (step 3) a step of purifying the polymer (A2) using a subcritical or supercritical fluid to obtain the polymer (A). The first monomer is selected from one of a first group consisting of epoxy group-containing monomers or a second group consisting of carboxy group-containing monomers. The second monomer is selected from the other of the first group or the second group.SELECTED DRAWING: None

The invention relates to a corneal contact lens and a preparation method thereof, the corneal contact lens comprises a contact lens body and a plurality of degradable microneedles, the plurality of degradable microneedles are arranged on the contact lens body, the preparation method comprises the following steps: preparing a female die, pouring a polydimethylsiloxane prepolymerization liquid and a curing agent into the female die, and forming a preliminary die after molding; a silicon hydrogel prepolymerization solution is injected into a contact lens cavity, a material corresponding to an outer layer is injected into a microneedle cavity, then a material corresponding to an inner layer is injected, finally a substrate material is injected, after curing, the two materials of the outer layer and the inner layer form molecular-level physical embedding on an interface so as to form a microneedle main body, and the microneedle main body is directly fixed on a silicon hydrogel substrate; stripping from the mold to obtain the corneal contact lens; the extracted exosome is loaded to the inner layer and the outer layer in a double-layer partition loading mode. According to the cornea contact lens and the preparation method, the treatment cycle can be remarkably shortened, the medical cost is reduced, meanwhile, repeated medical treatment and operation risks are avoided, and the cornea contact lens makes close contact with the cornea, is not prone to displacement or falling off and is good in permeation effect.

Batches of a thermally-curable, silicone hydrogel, contact lens formulation having a mass of at least 1 kg and a dynamic viscosity of greater than 15 CP at 25 o c comprising a thermally-activated radi

The invention relates generally to a silicone hydrogel-embedded contact lens comprising a silicone hydrogel material and a hydrophobic insert. The silicone hydrogel material comprises repeating units of at least one polysiloxane vinyl crosslinking prime comprising hydrophilized siloxane units, each having a methyl substituent and an organic radical including at least one hydrogen bond donor (e.g., hydroxyl groups), wherein the content of said at least one hydrogen bond donor is at least 0.8 meq / g relative to the molecular weight of said at least one polysiloxane vinyl crosslinking prime. The hydrophobic insert is composed of a crosslinked polymeric material comprising at least 40 mol% acrylic repeating units and at least 6 mol% repeating units of at least one vinyl crosslinking agent. The embedded silicone hydrogel is not prone to delamination.

The present application relates to a kind of high ductility silicon hydrogel, which is prepared by polymerization reaction of polymerizable composition containing thiol with functionality greater than or equal to 3, and the elongation of the high ductility silicon hydrogel is 285%-439%.The present application also relates to a kind of high ductility contact lens and its preparation method.By adding thiol with functionality greater than or equal to 3 as crosslinking agent in the formula of silicon hydrogel, the formed silicon hydrogel polymer network is more regular, more full and more stretchy, so that the prepared contact lens has good ductility, and the contact lens has high water content and low modulus.In addition, compared with the contact lens formed without adding thiol with functionality greater than or equal to 3, the size change of the contact lens formed after adding thiol with functionality greater than or equal to 3 is less than 5%.

The invention relates to the field of organic silicon materials, and particularly discloses a polyether modified silicone oil cross-linking agent as well as a preparation method and application thereof. The structural general formula of the polyether modified silicone oil cross-linking agent is shown in the specification, wherein the structural formula of R1 and the structural formula of R3 are-CH2-or-CH2-CH2-CH2-O-; the structural formulas of R1, R2 and R4 are one of-H, C1-C10 and the like; the structural formula of R5 is shown in the specification; the structural formula of R6 is shown in the specification; the value range of a is an integer between 0 and 60, the value range of b is an integer between 1 and 12, and the value range of c is an integer between 1 and 40. According to the polyether modified silicone oil cross-linking agent, the compatibility of an organic silicon monomer and a hydrophilic monomer can be greatly improved, so that the prepared material has relatively high mechanical strength, and the requirements of xerophthalmia patients and people wearing contact lenses for a long time can be met in the aspects of comfort and safety; particularly, the preparation method has a good application prospect in the field of preparation of silicone hydrogel lenses.

The present invention provides a class of high RI polysiloxane vinylic crosslinkers. The polysiloxane vinylic crosslinkers of the invention each comprise (1) a polysiloxane segment comprising dimethylsiloxane units and aryl-containing siloxane units each having one methyl substituent and one organic substituent having up to 45 carbon atoms and at least one aryl moiety connected to the Si atom through a linking group having at least 2 (preferably 3) carbon atoms; and (2) an ethylenically unsaturated group. The invention also provides an insert or a silicone hydrogel contact lens comprising a crosslinked polymeric material comprising repeat units of at least one of such high RI polysiloxane vinylic crosslinkers.

The present invention generally relates to an embedded silicone hydrogel contact lens comprising a silicone hydrogel material and a hydrophobic insert. The silicone hydrogel material comprises repeating units of at least one first polysiloxane vinyl crosslinker comprising hydrophilized siloxane units each having a methyl substituent and an organic group comprising at least one H-bond donor (e.g., a hydroxyl group), wherein the at least one H-bond donor is present in an amount of at least about 0.8 meq / g relative to the molecular weight of the at least one first polysiloxane vinyl crosslinker. The hydrophobic insert is comprised of a crosslinked polymeric material comprising at least 40% by mole of repeating units of acrylic acid and at least 6% by mole of repeating units of at least one vinyl crosslinker. The embedded silicone hydrogel is not susceptible to delamination.

The invention provides a silicone hydrogel contact lens formulation comprising a difunctional siloxane, a hydrophilic N-vinyl amide monomer, and at least 0.10% (wt / wt) triphenylphosphine (TPP); a silicone hydrogel contact lens formed by polymerizing the silicone hydrogel contact lens formulation, and the use of TPP to improve the surface properties of a contact lens prepared from a formulation comprising a difunctional siloxane and a hydrophilic N-vinyl amide monomer.

The invention discloses a silicon hydrogel material as well as a preparation method and application thereof. The preparation method comprises the following steps: curing and molding 2-hydroxyethyl methacrylate (HEMA), 3-(trimethylsiloxy) propyl methacrylate (TRIS), ethylene glycol dimethacrylate (EGDMA), a silane coupling agent and a photoinitiator through a photopolymerization reaction to obtain a silicon hydrogel substrate; performing oxygen plasma treatment; preparing a PDMS hydrophobic layer; performing oxygen plasma treatment; soaking in an organic solution containing a hydrophobic initiator; and forming a hydrophilic polymer layer. The high oxygen permeability, long-acting moisture retention, low friction and protein deposition resistance of the lens are realized by constructing a'hydrophobic water locking-hydrophilic lubrication 'double-layer functional interface.

The present invention is related to reactive dyes each of which comprises a dichlorotriazine, chlorotriazine or vinylsulphonyl group and is capable of absorbing HEVL. They are suitable for method for producing colored silicone hydrogel contact lenses each made of a silicone hydrogel material having hydroxyl groups. The present invention is also related to a colored silicone hydrogel contact lens comprising a colored circular region in which a reactive dye is applied and thereby covalently attached.

Provided are a silicone hydrogel that has, even when being produced using a hydrophobic mold such as a polypropylene mold, excellent surface hydrophilicity that is stable for a long period of time without requiring a surface treatment such as a plasma treatment, and a method for producing the same. The silicone hydrogel according to one embodiment of the present invention contains water, and in a dried body produced by removing water from the silicone hydrogel, a ratio (A′ / B′) of an average value (A′) of O / Si concentration ratios at a first measurement point to a third measurement point to an average value (B′) of O / Si concentration ratios at a 14th measurement point to a 16th measurement point, which are separately defined, is 1.20 or more.