Silicone hydrogel contact lens

a technology of silicone hydrogel and contact lens, which is applied in the field of contact lenses, can solve the problems of polarization techniques not providing accurate measurements of high-dk the surface wettability of existing silicone hydrogel contact lenses is not desirable, and the contact lens surface is more hydrophilic. , to achieve the effect of improving the properties of silicone hydrogel contact lenses

Inactive Publication Date: 2006-03-23
COOPERVISION INT LTD
View PDF97 Cites 293 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0013] To help improve the properties of silicone hydrogel contact lenses, some lenses have been produced which include one or more surface treatments or surface modifications to attempt to make the lens surfaces more hydrophilic. Other lenses have been produced which include an interpenetrating network of polyvinylpyrollidone and a silicon-containing polymer.

Problems solved by technology

Hard contact lenses are literally hard and can be somewhat uncomfortable to wear.
However, it appears that the polarographic techniques may not provide accurate measurements for high Dk silicone hydrogel contact lenses, such as silicone hydrogel contact lenses having a Dk greater than about 100 barrers.
Furthermore, existing silicone hydrogel contact lenses do not have desirable surface wettabilities.
One problem that arises in extended or continuous wear contact lenses is adhesion of the lens to the cornea during lens wearing which can result in wearer discomfort, eye irritation, corneal staining and / or other damage to the eye.
Although lenses with high water contents are softer and more comfortable to wear, such prior art lenses may not have one or more properties useful to provide comfortable and safe wearing of the contact lenses.
For example, existing contact lenses may not have a desirable Dk, a desirable surface wettability, a desirable modulus, a desired design, and / or a desirable water content.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Silicone hydrogel contact lens
  • Silicone hydrogel contact lens
  • Silicone hydrogel contact lens

Examples

Experimental program
Comparison scheme
Effect test

synthesis example 1

Synthesis of Polysiloxanediol having Hydrosilane Groups (A1)

[0120] A mixture of 150 gms of octamethylcyclotetrasiloxane, 22.6 gms of 1,3,5-trimethyltrifluoropropyl-cyclotrisiloxane, 5.2 gms of 1,3,5,7-tetramethyl-cyclotetrasiloxane, 9.8 gms of 1,3-bis(3-(2-hydroxyethoxy)propyl)tetramethyldisiloxane, 200 gms of chloroform and 1.5 gms of trifluoromethane sulfonic acid was stirred for 24 hours at 25° C., then washed repeatedly with purified water until a pH of the mixture became neutral. After water was separated, chloroform was distilled off under the reduced pressure. The residual liquid was dissolved in acetone (36 gms), reprecipitated with methanol (180 gms), followed by removal of volatile components under vacuum from a separated liquid to give a transparent viscous liquid. The said liquid was the siloxanediol having hydrosilane groups expressed by the following formula (H3R) with a yield of 125 gms. Here, although the structural formula of the linking group Y is shown as a block...

synthesis example 1a

[0123] Synthesis Example 1 is repeated with appropriate adjustments to the amounts of the components and / or conditions utilized to provide a macromer structured similarly to M3-U except that Y has the following structure:

[0124] This material, identified as M3-UU, has a number average molecular weight of about 20,000.

synthesis example 2

[0125] A mixture of 50 gms of alpha-butyl-omega-[3-(2′ hydroxyethoxy)propyl)polydimethylsiloxane, 10 gms of methacryloyloxyethyl isocyanate, 150 gms of dry n-hexane and 0.2 gms of dibutyltin dilaurate was poured in a brown-colored flask and heated for 2 hours under reflux, then further stirred after an addition of 6 gms of methanol. Subsequently, n-hexane was distilled off under reduced pressure, and the resulting liquid was washed several times with methanol (30 gms) / water (15 gms) followed by removal of volatile components under vacuum to give a transparent viscous liquid with a yield of 54 gms. The liquid was the polysiloxane-methacrylate (FMM) expressed by the following formula.

This material, identified as FMM, has a number average molecular weight of about 1500.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
contact angleaaaaaaaaaa
elongationaaaaaaaaaa
water contentaaaaaaaaaa
Login to view more

Abstract

Ophthalmically compatible contact lenses include lens bodies configured for placement on a cornea of an animal or human eye. The lens bodies are made of a hydrophilic silicon-containing polymeric material. The lens bodies have oxygen permeabilities, water content, surface wettabilities, flexibilities, and/or designs to be worn by a lens wearer even during sleep. The present lenses can be worn on a daily basis, including overnight, or can be worn for several days, such as about thirty days, without requiring removal or cleaning.

Description

CROSS REFERENCE TO RELATED APPLICATIONS [0001] This application claims the benefit of U.S. Provisional Application No. 60 / 604,961, filed Aug. 27, 2004 and U.S. Provisional Application No. 60 / 621,525, filed Oct. 22, 2004, the contents of which in their entireties are hereby incorporated by reference.BACKGROUND OF THE INVENTION [0002] The present invention relates to contact lenses which are wearable, on a continuous basis, for extended periods of time. In particular, the invention relates to flexible, hydrophilic silicon-containing contact lenses which have advantageous combinations of properties. [0003] Contact lenses are fundamentally classified into soft and hard type lenses. Hard contact lenses are literally hard and can be somewhat uncomfortable to wear. On the other hand, soft contact lenses are more comfortable to wear, but are commonly removed from the eye at the end of each day. Soft contact lenses are classified as hydrogel lenses and non-hydrogel lenses. [0004] Conventiona...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(United States)
IPC IPC(8): G02B1/04
CPCG02B1/043C08L83/04C08L51/085
Inventor IWATA, JUNICHIHOKI, TSUNEOIKAWA, SEIICHIROUBACK, ARTHUR
Owner COOPERVISION INT LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap