86 results about "Oxygen permeability" patented technology

The invention discloses a side-chain type amphiphilic organosiloxane macromonomer and a preparation method and application thereof, the side-chain type amphiphilic organosiloxane macromonomer can be well mixed with various hydrophilic monomers under the condition of no hydrotropy of a solvent, and a silicon hydrogel material with high oxygen permeability and high hydrophilicity can be prepared. The invention also discloses a silicon hydrogel which is prepared from the side chain type amphiphilic organosiloxane macromonomer and the following components through polymerization reaction: 5-45 parts of side chain type organosiloxane macromonomer, 0-30 parts of micromolecular silicon monomer, 25-70 parts of hydrophilic monomer, an initiator and a cross-linking agent. The silicon hydrogel has good hydrophilic performance, high light transmittance and high oxygen permeability. Meanwhile, the invention further discloses a corneal contact lens which is made of the silicone hydrogel material and has the advantages of being good in oxygen permeability, hydrophilicity, light transmission, wearing comfort and the like.

The invention belongs to the technical field of contact lenses, and provides a high-oxygen-permeability silica hydrogel and a silica hydrogel contact lens. The product is prepared from the following raw materials in parts by mass: 20 to 90 parts of organic silicon monomer, 20 to 80 parts of hydrophilic monomer, 0.1 to 5 parts of cross-linking agent, 0.2 to 7 parts of initiator and 20 to 50 parts of solvent. Symmetrical monomethacryloyloxy propyl modified polydimethylsiloxane, methyl-di (trimethylsiloxy)-silyl propyl glyceryl methacrylate and 2-(trimethylsiloxy) ethyl methacrylate are selected as organic silicon monomers together, and the three organic silicon monomers cooperate with one another, so that the viscosity of the organic silicon resin is improved; the oxygen permeability of the lens is improved; and the three organic silicon monomers and the hydrophilic monomer have good solubility. In addition, the sample is soaked in an isopropanol solution, so that the transparency of the lens is improved, and meanwhile, a channel on the lens is opened, so that the oxygen permeation coefficient of the lens is improved.

The invention provides an amnion-loaded contact lens and a preparation method and application thereof. According to the invention, the bonding mode of the amniotic membrane and the contact lens is innovated, the previous mode of simply bonding the amniotic membrane and the contact lens by using medical biological glue is changed, the bonding procedure of the amniotic membrane and the contact lens is simplified, and the method is suitable for industrial application; the problems that the mechanical supporting force is reduced, the amniotic membrane is broken and the coverage is uneven due to the fact that the ocular surface coverage time of a traditional suture type amniotic membrane is prolonged are solved; in the aspect of material optimization and selection, the basic requirement of non-toxicity and harmlessness of the adhesive is met, and meanwhile, the requirements of biocompatibility and the oxygen permeability of the cornea on the contact lens are also considered; the amniotic membrane is more comfortable in the using process, complex operation procedures are not needed, and stimulation caused by no suture is avoided; the design scheme that the contact lens is used as the amniotic membrane support enables the amniotic membrane lens to provide better support and protection for the covered ocular surface.

A high oxygen permeability silicone hydrogel composition, contact lens made from the high oxygen permeability silicone hydrogel composition and manufacturing method of the contact lens are disclosed. The high oxygen permeability silicone hydrogel composition includes a first silicone polymer, a second silicone polymer, at least one hydrophilic monomer, a crosslinking agent, an initiator, and a solvent. By adjusting the ratio of each silicone polymer molecule and the hydrophilic monomer in the contact lens, the present invention can not only provide the contact lens with high oxygen permeability, but also expand the design scope of the silicone hydrogel contact lens.

The invention discloses a high-oxygen-permeability membrane material and a preparation method thereof, and belongs to the technical field of membrane materials. The membrane material is prepared by taking polydimethylsiloxane and polycaprolactone as organic raw materials, adding an inorganic material nano titanium dioxide or graphene, and carrying out solution preparation, cross-linking reaction, casting membrane formation, hot press molding, plasma treatment and surface modification. The polydimethylsiloxane guarantees the oxygen permeability, the polycaprolactone improves the flexibility and the biocompatibility, and the nano inorganic particles enhance the mechanical strength and the antibacterial property. The prepared membrane material is improved in oxygen permeability coefficient, greatly improved in tensile strength and elongation at break, good in hydrophilicity and biocompatibility, low in cytotoxicity and small in hemolysis rate, can be widely applied to medical products such as artificial lungs, wound dressings and contact lenses, and effectively meets the requirements of the medical field for the membrane material with high oxygen permeability and good comprehensive performance.

The invention discloses a high-mechanical-property orthokeratology lens material copolymer and a preparation method thereof, and relates to the technical field of high polymer materials. The used raw materials comprise a fluorosilicone material, a hydrophilic monomer, an initiator and a cross-linking agent; the method comprises the following steps: mixing a monomer and an initiator according to a preset ratio, degassing, and carrying out two-stage heating polymerization reaction in a mold. After the polymerization reaction is finished, the copolymer in the mold is taken out, and the required orthokeratology lens material copolymer with the high mechanical property can be obtained through cleaning and drying treatment. The process is simple in reaction step and short in reaction time, the reaction rate can be controlled, and the production cost of the orthokeratology lens is reduced. The copolymer has high oxygen permeability and excellent optical performance, and meanwhile, compared with common like products, the copolymer shows good mechanical performance. The composition is especially suitable for preparing myopia lenses, orthokeratology lenses (OK lenses) or rigid breathable contact lenses (RGP lenses), can provide excellent visual effects and wearing comfort, and reduces irritation to eyes.

A liquid-containing container is the liquid-containing container containing a liquid and includes a container body with an opening portion and a stopper that closes the opening portion and has oxygen permeability. The stopper includes a stopper body portion and a barrier layer provided on at least part of a surface of the stopper body portion. The barrier layer constitutes at least a surface of a portion of the stopper to be inserted into the container body and a surface of the stopper defining a storage space for the liquid and includes at least one selected from the group consisting of a p-xylylene layer, a diamond-like carbon layer, and a fluoropolymer layer.

The invention provides a contact lens with a surface hydrophilic coating and a preparation method thereof, and relates to the technical field of contact lenses. The preparation method comprises the following steps: mixing an acrylate monomer, a fluorine-containing siloxane compound, an initiator I, a cross-linking agent, glycerol and water to obtain a pre-polymerized solution I; mixing an unsaturated ester compound, N-vinyl pyrrolidone, polyvinyl alcohol, phosphatidylcholine, an initiator II, alcohol and dimethyl sulfoxide to obtain a pre-polymerized solution II; coating the pre-polymerization liquid II on the surface of a contact lens mold for heating and curing; and injecting the pre-polymerized liquid I into a mold for curing to obtain the contact lens with the surface hydrophilic coating. Phosphatidylcholine is adopted as a raw material to prepare the hydrophilic coating of the silicone hydrogel contact lens, the contact lens is of a three-layer structure, the outer layer is the hydrophilic gel coating and is soft and comfortable, the inner layer is a silicone hydrogel system and is high in oxygen permeability, the contact lens is more comfortable in the wearing process, and foreign body sensation can be effectively avoided.

The invention discloses a silicone hydrogel polymer material for contact lenses and a preparation method thereof, and relates to the field of high polymer materials. Siloxane monomers, hydrophilic monomers and a dynamic cross-linking agent are mixed to obtain a monomer mixed solution; mixing functional nanoparticles, the monomer mixed solution and an initiator to obtain a pre-polymerized solution; according to the silicon hydrogel polymer material for the contact lens, the cyclic siloxane monomer and the linear siloxane are copolymerized to form a hydrophobic micro-area with a controllable size, the oxygen permeability is optimized, a borate bond is introduced as a dynamic crosslinking point, a network is reconstructed when ocular surface inflammation occurs, and the contact lens has the advantages that the contact lens is not prone to inflammation; functional nano-particle loaded anti-inflammatory and antibacterial components are released, and the high-oxygen-permeability, intelligent anti-inflammatory and antibacterial, ultra-durable and comfortable silicon hydrogel polymer material for the contact lenses is obtained.

The present invention provides an amniotic membrane-loaded contact lens, its preparation method, and its application. This invention innovates the bonding method between amniotic membrane and contact lens, replacing the previous method of simply bonding the amniotic membrane and contact lens with medical biological glue. This simplifies the bonding process between amniotic membrane and contact lens, making it suitable for industrial application. It also addresses the issues of traditional sutured amniotic membranes, which suffer from decreased mechanical support, rupture, and uneven coverage over time as they cover the ocular surface. The optimization and selection of materials not only meet the basic requirements of a non-toxic and harmless adhesive, but also take into account biocompatibility and the cornea's requirements for contact lens oxygen permeability. The use of amniotic membranes is more comfortable, eliminating the need for complex surgical procedures and the irritation associated with sutures. The design of using a contact lens as an amniotic membrane support allows amniotic lenses to provide superior support and protection for the covered ocular surface.

The invention relates to the technical field of contact lenses, in particular to a myopia control contact lens based on an oxygen-permeable microstructure, which comprises an inner side surface in contact with cornea and an outer side surface opposite to the inner side surface, the two ends of each microstructure hole are communicated with the inner side surface and the outer side surface; an inner correction surface is arranged on the inner side surface, an outer correction surface is arranged on the outer side surface, and a correction area for vision correction is arranged between the inner correction surface and the outer correction surface; any end of each microstructure hole is not communicated with the inner correction surface or the outer correction surface; and the microstructure holes have the same diameter. According to the scheme, the oxygen permeation amount can be increased, and meanwhile the myopia progress is delayed.

The invention discloses a contact lens material, a contact lens containing the same and a preparation method of the contact lens material. The contact lens material is prepared from the following raw materials: hydroxyethyl methylacrylate, 2-methacryloyloxyethyl phosphorylcholine, azophenyl methacrylate, ethylene glycol dimethacrylate, 3-(methacryloyloxy) propyltrimethoxysilane, 2-acrylic acid 2-(4-benzoyl-3-hydroxyphenoxy) ethyl ester, isobornyl methacrylate, a solvent, a solvent, a solvent and a solvent. The component A is prepared from the following raw materials: tetrahydrolinalool, N-vinyl pyrrolidone, azodiisobutyronitrile, methacrylic acid and sodium hyaluronate; pDMS (Polydimethylsiloxane)-mono MA (Methacrylate) and IEM-PDMS (Induced The contact lens material provided by the invention has the advantages of good hydrophilicity, high water content and good biocompatibility, and the prepared contact lens has good oxygen permeability and water content, is comfortable to wear, also has ultraviolet protection and purple light and blue light filtering functions, and better protects eyes.

Described is a silicone hydrogel contact lens having non-uniform morphology. The contact lens may be made from a reactive mixture comprising: a silicone-containing component; a hydrophilic component; a non-reactive polymeric internal wetting agent; and a polymerization initiator, the contact lens having an oxygen permeability of at least about 60 barrers, and wherein the molar ratio in the lens of the polymeric non-reactive internal wetting agent to silicone, without a surface treatment, is greater in the lens's surface than in its bulk.

The invention provides a degradable contact lens and a preparation method thereof, and belongs to the technical field of contact lenses. The preparation method comprises the following steps: firstly, dissolving collagen in an acetic acid solution to obtain a collagen solution; dissolving hyaluronic acid in water to obtain a hyaluronic acid solution; the hyaluronic acid is formed by mixing first hyaluronic acid and second hyaluronic acid, the molecular weight of the first hyaluronic acid is 50-300 kDa, and the molecular weight of the second hyaluronic acid is 800-1500 kDa; and finally, mixing the collagen solution and the hyaluronic acid solution, and sequentially carrying out first crosslinking, second crosslinking and post-treatment to obtain the contact lens. The contact lens prepared by the invention has high oxygen permeability, proper mechanical properties and controllable degradability.

The present invention discloses a liquid sac-shaped corneal contact lens and a preparation method thereof. The liquid sac-shaped corneal contact lens is composed of a transparent film and a transparent oxygen-permeable liquid, and the oxygen-permeable liquid is wrapped inside the film; the film includes an inner elastomer layer and an outer hydrophilic polymer hydrogel layer. The liquid sac-shaped corneal contact lens of the present invention has the characteristic of being able to change its shape, can remain in a narrow pipeline in the form of a liquid drop, can be directly dropped into the eye from the pipeline, spread out on the corneal surface, is convenient to carry and has a simple wearing method.

The present invention provides a contact lens monomer composition using a small molecular weight organosilicon compound, a polymer of the composition, and a contact lens using the polymer, which can produce a contact lens having excellent oxygen permeability, mechanical strength, transparency, durability, and wearing sensation. Specifically, a composition containing (A) a methacrylate monomer containing a phosphoryl choline group, (B) an itaconic acid diester monomer containing a siloxane group, (C) a specific hydrophilic monomer, (D) a (meth)acrylate containing a siloxane group, and (E) a specific crosslinking agent in specific proportions, a polymer thereof, and a contact lens using the polymer.

The embodiment of the present application relates to the technical field of optical material manufacturing, and specifically discloses a medical optical material, a preparation method and application thereof, the medical optical material comprises the following raw materials: photosensitive resin, crosslinking agent, photoinitiator, inhibitor and ultraviolet blocking monomer. The embodiment of the present application adopts a continuous liquid surface photocuring technology based on a 405nm light source, realizes steep polymerization threshold and stable inhibition layer through O2 / TEMPO double inhibition, significantly reduces ghosting and window sticking, and completes deep layer crosslinking in an N2 environment while inhibiting yellowing and haze through secondary UV irradiation and heat post-curing, thereby solving the problem that most existing orthokeratology lenses adopt a traditional layered photocuring process and are prone to defects such as ghosting and yellowing. Moreover, the preparation method provided by the embodiment of the present application is simple, can be used for preparing orthokeratology lenses and other optical components with high optical quality, high oxygen permeability and biocompatibility, and has a broad market prospect.

The invention relates to the technical field of high polymer materials, and particularly discloses a high polymer material for a rigid orthokeratology lens and a preparation method of the high polymer material. The high polymer material for the rigid orthokeratology lens comprises the following components in parts by weight: 30-50 parts of an organosiloxane monomer; 5-15 parts of a perfluoroalkyl ester monomer; 10 to 20 parts of a sulfone monomer; 20 to 40 parts of a hardening agent; 5-10 parts of a cross-linking agent; and 3-6 parts of a wetting agent. Researches show that the high polymer material for the rigid orthokeratology lens has a relatively high oxygen permeability coefficient, and overcomes the technical defect of poor oxygen permeability of fluorine-containing siloxane or methacrylate polymers in the prior art; the important application value is realized. In addition, by adding the wetting agent, the surface hydrophilicity of the high polymer material for the rigid orthokeratology lens can be improved, and the anti-fouling performance of the high polymer material can be improved; by adding the hardening agent, the mechanical property of the high polymer material for the rigid orthokeratology lens can be further improved.

The invention relates to the technical field of adhesives, in particular to a high-weather-resistance self-repairing optical adhesive and a preparation method thereof. The fluorine-containing silicone rubber composition comprises 85-95 parts of a fluorine-containing silicone prepolymer; 2-5 parts of a photoinitiator solution; 3-10 parts of a silane coupling agent; the fluorine-containing siloxane prepolymer, the benzene boric acid ester monomer, the multifunctional acrylate, the photoinitiator and the silane coupling agent are compounded, so that the prepared high-weather-resistance self-repairing optical adhesive simultaneously realizes ultralow water and oxygen permeation, self-repairing under mild conditions and yellowing resistance, and meets the outdoor durability requirement of a display screen.

The invention relates to the technical field of preparation of contact lens materials, in particular to a high-weather-resistance silicone hydrogel contact lens material and a preparation method thereof. The preparation method of the contact lens material comprises the following steps: S1, adding a polymeric monomer, a weather-proof additive and a functional additive into absolute ethyl alcohol, and stirring in a dark place to obtain a premixed solution; and S2, adding nano silver and nano titanium dioxide into the premixed solution, performing ultrasonic dispersion, adding a cross-linking agent and an initiator, performing uniform mixing, injecting the mixture into a contact lens mold, performing photo-initiation polymerization reaction under the protection of inert gas, and performing washing with deionized water and equilibrium with a boric acid buffer solution to obtain the high-weather-resistance silicon hydrogel contact lens material. The prepared contact lens material not only has high oxygen permeability and high light transmittance, but also can effectively ensure that the cornea obtains sufficient oxygen, and is also excellent in weather resistance and not easy to deform or damage.

The invention discloses a fixed-axis contact lens capable of preventing highlight patterns from rotating. The fixed-axis contact lens comprises an optical area located in the center, a balance area arranged around the optical area, auxiliary supporting areas symmetrically arranged on the left side and the right side below the balance area, a thinning area arranged above the balance area and a vertical weight area arranged below the auxiliary supporting areas. Transition buffer areas are arranged on the peripheries of the thinning area, the auxiliary supporting area and the vertical weight area, and edge areas are arranged on the peripheries of the transition buffer areas. According to the invention, the thinning area and the vertical weight area are oppositely arranged in the vertical direction, and the asymmetric thickness structure of the auxiliary supporting area is combined, so that a vertical and horizontal two-dimensional anti-rotation locking mechanism is formed, the angle deviation of the highlight pattern can be controlled within + / -1 degree, and meanwhile, the oxygen permeation rate and the wearing comfort are ensured; the contact lens is suitable for highlight decoration and astigmatism correction.

Provided is a monomer composition for contact lenses, which uses a polysiloxane monomer to produce a polymer that shows satisfactory surface hydrophilicity and oxygen permeability, and that is excellent in modulus and elongation at break. It has been found that a monomer composition containing a phosphorylcholine group-containing polysiloxane monomer, a monovinyl ether monomer, and the like can achieve the above-mentioned object.

The invention discloses a biodegradable film which is of a four-layer composite structure and sequentially comprises a heat sealing layer, a core base material layer, a blocking layer and an anti-scraping coating from inside to outside. The 60-day biodegradation rate of the biodegradable film is larger than or equal to 90%, the haze is smaller than or equal to 3%, the oxygen permeability is smaller than or equal to 50 cc / (m < 2 >. Day. Atm), the water vapor permeability is smaller than or equal to 5 g / (m < 2 >. Day. Atm), the heat sealing strength is larger than or equal to 3 kgf / 15 mm, the heat shrinkage rate is 4-6%, and the longitudinal and transverse shrinkage difference is smaller than 0.5%. The invention further discloses a preparation method and application of the biodegradable film.

The invention relates generally to an insert intended to be embedded in a silicone hydrogel contact lens. The insert is made of crosslinked materials that are rigid in the dry state at room temperature (approximately 22°C to approximately 26°C), have high oxygen permeability and a high refractive index in the fully hydrated state, and can be softened at temperatures above 32°C. Such materials are useful in the manufacture of embedded contact lens inserts for correcting corneal astigmatism, presbyopia, and color blindness, and for imparting photochromic characteristics to the lenses. The invention also relates to a method for manufacturing embedded silicone hydrogel contact lenses comprising an insert of the invention, and embedded silicone hydrogel contact lenses comprising an insert of the invention.

The present invention provides an ophthalmic lens that has both oxygen permeability and surface hydrophilicity and has lipid adhesion suppressed. The ophthalmic lens of the present invention is an ophthalmic lens comprising a polymer material obtained by polymerizing a polymerizable composition, the polymerizable composition comprising a siloxane monomer having a siloxane bond and a siloxane-free crosslinking monomer having no siloxane bond as monomer components, the siloxane-free crosslinking monomer comprising an alkylene glycol chain-containing crosslinking monomer having a chain portion comprising 6 or more alkylene glycol repeating units and polymerizable groups disposed at both ends of the chain portion.

The present invention relates to the technical field of hydrogels, and particularly to a high-strength and wet-slippery PVA hydrogel, a preparation method thereof and an application thereof. The preparation method of the high-strength and wet-slippery PVA hydrogel provided by the present invention includes: performing water evaporation treatment on an aqueous solution of polyvinyl alcohol to obtain a PVA dry gel; performing salting-out treatment on the PVA dry gel in a sodium salt solution and then performing water balance to obtain the high-strength and wet-slippery PVA hydrogel. The high-strength and wet-slippery PVA hydrogel obtained by the preparation method of the present invention has both high light transmittance, hydrophilicity and lubricity, good biocompatibility and adjustable mechanical properties. At the same time, the present invention also provides the application of the high-strength and wet-slippery PVA hydrogel in contact lenses. The contact lenses made therefrom have high transparency, good oxygen permeability and excellent smoothness, and completely solve the problem of poor hydrophilicity existing on the surface of traditional silicone hydrogel contact lenses, thereby improving the requirement for the wearing comfort of contact lenses.

The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.

The present invention provides a hard contact lens that has high oxygen permeability and a large bending deformation capacity, making it resistant to breakage from bending deformation, and a hard contact lens material that can be used to manufacture such a hard contact lens. [Solution] According to one aspect of the present invention, a hard contact lens material is provided, comprising a substituted methacrylate (A) having a molecular structure in which the ratio of the number of fluorine atoms to the number of carbon atoms is 0.6 or more and 0.9 or less, a substituted styrene (B), a methacryloyl group-containing silicone monomer (C), a (meth)acryloyl group-containing monomer (D), an unsaturated double bond-containing hydrophilic monomer (E), and a methacryloyl group-containing monomer (F), wherein the molar ratio of (meth)acryloyl group-containing monomer (D) to methacryloyl group-containing monomer (F) is 0.12 or more and 0.2 or less.

A contact lens constructed to limit the water transmissibility of at least one area of the lens while maintaining at least a minimum oxygen transmissibility. The water transmissibility maximum and oxygen permeability minimum are achieved by a predetermined lens thickness of a single lens material or by the use of two or more material layers.

The invention belongs to the technical field of contact lens materials, and discloses a high-moisture-retention contact lens material and a preparation method thereof. The raw materials of the invention comprise 50-70 parts of a silicon-based monomer, 40-60 parts of a hydrophilic monomer, 5-15 parts of hyaluronic acid, 3-10 parts of water-soluble collagen, 2-8 parts of modified chitosan, 1-5 parts of a moisturizing aid, 0.5-3 parts of a cross-linking agent, 0.1-1 part of a photoinitiator and 10-20 parts of water. The contact lens material prepared by the invention is low in water loss rate, long in moisturizing time, excellent in biocompatibility, excellent in oxygen permeability, simple in preparation process and easy to industrialize.