2037 results about "Macromonomer" patented technology

Problem to be Solved To provide an ophthalmic lens, which can be more safely worn, that is, to provide a material, which is transparent and has high oxygen permeability and a high hydrophilic property, and to provide a novel monomer to be a raw material thereof.

Solution A hydrophilic polysiloxane macromonomer contains polyoxyethylene as a hydrophilic side chains in a polysiloxane main chain, wherein transparency, oxygen permeability, and hydrophilic properties of the material are controlled by regulating the length of the polysiloxane main chain, the length of the hydrophilic polyoxyethylene side chains, and the number of the side chains.

A water-based ink for inkjet printing comprising a water dispersion of vinyl polymer particles prepared by containing a pigment in a vinyl polymer prepared by copolymerizing a monomer mixture comprising (a) a salt-forming group-containing monomer, (b) a macromer, and (c) a monomer copolymerizable with the salt-forming group-containing monomer and the macromer; and a process for preparing a water-based ink for inkjet printing comprising a water dispersion of vinyl polymer particles prepared by containing a pigment in a vinyl polymer, comprising dissolving in an organic solvent a vinyl polymer prepared by copolymerizing a monomer mixture comprising (a) a salt-forming group-containing monomer, (b) a macromer, and (c) a monomer copolymerizable with the salt-forming group-containing monomer and the macromer; adding a pigment to the resulting solution; pre-kneading the mixture; thereafter adding a neutralizing agent and water and kneading the mixture, to give an oil-in-water dispersion; and distilling off the organic solvent from the resulting kneaded product.

Composite membranes that exhibit long-term resistance to biofouling comprise a porous support and a crosslinked polyamide discriminating layer having an external surface, the discriminating layer comprising a branched poly(alkylene oxide) (PAO) polymer attached to its external surface. The branched PAO polymer typically has the structure of a molecular comb or brush, and is made by polymerization of a PAO macromonomer of the following formula:

RO—[(CHR′)_n—O]_m-V

in which R is hydrogen or a C_1-20 aliphatic or aromatic group, V is any group containing a polymerizable site, each R′ is independently hydrogen or a short chain alkyl group, n is an integer of 1-6, and m is an integer of 1 to about 200. The α end group can be either polymerized or copolymerized.

An arthroplasty device is provided having an interpenetrating polymer network (IPN) hydrogel that is strain-hardened by swelling and adapted to be held in place in a joint by conforming to a bone geometry. The strain-hardened IPN hydrogel is based on two different networks: (1) a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups, and (2) a non-silicone network of ionizable monomers. The second network was polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. Within the IPN, the degree of chemical cross-linking in the second network is less than in the first network. An aqueous salt solution (neutral pH) is used to ionize and swell the second network. The swelling of the second network is constrained by the first network resulting in an increase in effective physical cross-links within the IPN.

This invention provides novel methods for the formation of biocompatible membranes around biological materials using photopolymerization of water soluble molecules. The membranes can be used as a covering to encapsulate biological materials or biomedical devices, as a “glue” to cause more than one biological substance to adhere together, or as carriers for biologically active species. Several methods for forming these membranes are provided. Each of these methods utilizes a polymerization system containing water-soluble macromers, species, which are at once polymers and macromolecules capable of further polymerization. The macromers are polymerized using a photoinitiator (such as a dye), optionally a cocatalyst, optionally an accelerator, and radiation in the form of visible or long wavelength UV light. The reaction occurs either by suspension polymerization or by interfacial polymerization. The polymer membrane can be formed directly on the surface of the biological material, or it can be formed on material, which is already encapsulated.

The present invention relates to compositions and methods of treating a disease, such as diabetes, by implanting encapsulated biological material into a patient in need of treatment. This invention provides for the placement of biocompatible coating materials around biological materials using photopolymerization while maintaining the pre-encapsulation status of the biological materials. Several methods are presented to accomplish coating several different types of biological materials. The coatings can be placed directly onto the surface of the biological materials or onto the surface of other coating materials that hold the biological materials. The components of the polymerization reactions that produce the coatings can include natural and synthetic polymers, macromers, accelerants, cocatalysts, photoinitiators, and radiation. This invention also provides methods of utilizing these encapsulated biological materials to treat different human and animal diseases or disorders by implanting them into several areas in the body including the subcutaneous site. The coating materials can be manipulated to provide different degrees of biocompatibility, protein diffusivity characteristics, strength, and biodegradability to optimize the delivery of biological materials from the encapsulated implant to the host recipient while protecting the encapsulated biological materials from destruction by the host inflammatory and immune protective mechanisms without requiring long-term anti-inflammatory or anti-immune treatment of the host.

The invention discloses a temperature resistant salt tolerant high efficiency gel and a preparation method and application thereof. The preparation method is characterized in that the preparation method comprises the following steps: preparing a comb-shaped associated copolymer PAH containing macromonomers and functional hydrophobic monomers into an aqueous solution having the concentration of 0.1 to 4g/L, the crosslinking agent concentration of 0.01 to 1.0g/L, the surfactant concentration of 0.01 to 8mmol/L and the sodium sulfite thermal stabilizer concentration of 0.005 to 1.0g/L; adding the aqueous solution into a mixing container with a stirring device; stirring the aqueous solution evenly at the room temperature; regulating the pH value of the solution to be equal to between 4 and 11, and obtaining a temperature resistant salt tolerant high efficiency gel polymer solution system used for tertiary oil recovery and scavenge, displacement modification, profile modification or water shutoff. The polymer solution system has micro-crosslinking to form the gel during the flowage inside the oil reservoir. The gel has good elasticity, not easy dehydration, stable gelling performance, and excellent tackification, temperature resistance, salt tolerance, shearing resistance and ageing resistance.

Low molecular weight siloxane materials having one functional group are provided which have reduced tendency to form phase separated domains after polymerization. Two classes of siloxane materials are included: (1) symmetric siloxane macromonomers containing at least two monomer termini and one polymerizable functional group which is equidistant from the termini, and (2) assymetric siloxane macromonomers having at least one polymerizable functional group terminus and at least one oxygen-containing polar hydrophilic terminus selected from the group consisting of hydroxyl, ether, and polyether. Symmetric siloxane macromonomers having hydroxyl termini are useful for forming biocompatible materials, such as for contact lenses, tissue regeneration scaffold polymers, and coatings to reduce non-specific binding of proteins.

Hydrogel biomedical articles formed from macromers having a polymeric backbone comprising 1,2-diol and/or 1,3-diol units, such as polyvinyl alcohol, and pendant chains bearing crosslinkable groups and, optionally, other modifiers.

A surgical tissue adhesive composition contains at least one 1,1-disubstituted electron-deficient olefin macromer. The adhesive composition of the invention has improved biocompatibility as well as controlled biodegradation characteristics and bioactivity. Adhesive co-monomer compositions contain at least one macromer with a pendant oligomer, polymer, or peptide chain as an acrylic ester of the reactive olefin. The polymers formed therefrom have a grafted brush-like nature. The composition is particularly useful for creating an adhesive bond at the junction of living tissue in surgical applications. The adhesive composition may further comprise co-monomer, co-macromer, cross-linker, or inter-penetrating polymer compounds containing peptide sequences that are bioactive or enzyme responsive. The peptide sequences are selected to promote tissue infiltration and healing in a particular biological tissue. The sequences may contain specific cell-adhesion, cell-signaling, and enzyme-cleavable domains. Furthermore, a degradable filler material may be included in the composition to create a reinforced composite. The filler preferably has a higher degradation rate than the polymer matrix, generating porosity upon degradation. The adhesive may further contain entrapped or incorporated drugs or biologics, including antibiotics or growth factors. The adhesive can be used to bind together the edges of living tissues during surgical procedures. The cured composition provides interfacial bonding and mechanical fixation while promoting tissue infiltration and replacement of the adhesive polymer.

Methods of preparing an antioxidant polymer are described comprising polymerizing macromonomers that comprise an antioxidant. By having the antioxidant as part of the macromonomer, a polymer with a higher density of antioxidants is prepared more efficiently than coordinating antioxidants to an already formed polymer. The methods of polymerization also encompass copolymerization wherein different macromonomers comprising different antioxidants may be used. Alternatively, the other macromonomer, or monomer, may not include an antioxidant depending on the intended use of the copolymer and desired properties. The macromonomer comprising a antioxidant may comprise more than one antioxidant which may be the same or different. In one embodiment, the macromonomer is benzene or olefin based, wherein the benzene or olefin is substituted with an antioxidant.

The invention discloses a high-performance polycarboxylate water reducing agent. The polycarboxylate water reducing agent has a structural general formula shown as a structural formula (I). The invention further provides a preparation method of the high-performance polycarboxylate water reducing agent. Apart from a polyether macromonomer and an unsaturated carboxylic acid monomer, an unsaturated phosphate monomer is added to obtain a product, namely, the high-performance polycarboxylate water reducing agent having a phosphate structure. The polycarboxylate water reducing agent disclosed by the invention is safe and simple in preparation process, environmentally friendly, low in energy consumption, low in cost, and suitable for industrial large-scale production. In the structural formula (I), R1 is -H, -COO- or -CH2COO-; R2 is -H or -CH3; R3 is -H or -CH3; R4 is -H or -CH3; R5 is -H or -CH3; R6 is -CH2- or -CH2CH2-; X, Y, Z and n are integers; X=1-100; Y=1-100; Z=1-100; and n=22-53.

The invention discloses an acrylamide modified graft copolymer and a preparation method and usage thereof. The invention is characterized in that 20 parts of acrylamide, 1-20 anionic monomer and/or cationic monomer, 0.1-15 macromonomer, 0.05-10 ionic lyophobic monomer and 50-1000 deionized water are added into a three-necked reaction bottle, the pH value is adjusted to be 3-9, N2 is introduced for 30min, then 0.002-0.5 part of initiator persulfate is added at 30-75 DEG C, the reaction lasts 8-36h, then copolymer PAB is obtained, and finally water is used for dilution to obtain strong PAB solution. During polymerization, no surfactant is used, and the macromonomer with a long chain and the ionic lyophobic monomer with intermolecular association function are introduced into the copolymer PAB, so the capabilities of cooperative tackification and salt-resistance between the rigid conformation of a molecular chain and the intermolecular association can be played optimally, the PAB exhibits unique solution property and has higher colloidal viscosity in high saline solution than in fresh water, and the PAB obtains the capabilities of tackification, salt resistance, low surface tension and strong molecular association and can be used for the oil-displacing acrylamide modified graft copolymer. The copolymer is prepared into water solution with mass concentration of 0.2-3.0g/L and surfactant concentration of 0.01-2 mmol/L, then the water solution is added into a mixing vessel by a stirring device, and then a polymer oil-displacing agent with tackification, salt resistance and cutting resistance is obtained. The PAB has the functions of both a tackifier and a macromolecule surfactant. The copolymer PAB is prepared into water solution which has mass concentration of 0.05-7%, so the macromolecule surfactant with excellent surface activeness can be obtained and then applicable to an emulsifier, an emulsion splitter, a solubilizer and a wetting agent.

A transdermal drug delivery system is provided which includes an optionally crosslinked macromer-reinforced (meth)acrylic ester base copolymer pressure sensitive adhesive wherein the macromer includes repeat hydrophilic units.

The invention relates to a preparation method of a slow-setting polycarboxylic acid water reducing agent, which is implemented by carrying out free radical copolymerization reaction on allylsulfonate monomers, acrylic monomers, polyethylene glycol nono-methyl ether methacrylate macromonomers and maleic anhydride grafted beta-cyclodextrin macromonomers. The invention is characterized in that a beta-cyclodextrin side chain is introduced into a polycarboxylic acid main chain, so that the polycarboxylate water reducing agent has favorable slow setting property, micro air-entraining property and better fluidity. The obtained polycarboxylic acid water reducing agent has the advantages of stable product performance, strong adaptability to cement and favorable compatibility; and the cement paste fluidity is up to higher than 290mm (W/C=0.29), the water reducing rate of concrete is up to 30-40%, and the slump protection time is 3-5 hours. The preparation method provided by the invention has the characteristics of unique technique, excellent product performance and the like.

Compounds are synthesized that contain nitrogen and hindered phenol functionalities of an aromatic amine and hindered phenol for use as oxidative stabilizers for organic materials, paints, lubricants, elastomers, and in other applications. The disclosed methods can efficiently synthesize target monomers and polymers without the use of expensive catalysts. Further, the disclosed methods can scale up to industrially useful quantities. In general, the methods provide an improved, highly efficient and economical process for the synthesis of macromonomers having nitrogen containing moiety and sterically hindered phenols and their corresponding polymers.

The present invention provides materials that have high glucose and oxygen permeability, strength, water content, and resistance to protein adsorption. The materials include an interpenetrating polymer network (IPN) hydrogel that is coated with biomolecules. The IPN hydrogels include two interpenetrating polymer networks. The first polymer network is based on a hydrophilic telechelic macromonomer. The second polymer network is based on a hydrophilic monomer. The hydrophilic monomer is polymerized and cross-linked to form the second polymer network in the presence of the first polymer network. In a preferred embodiment, the hydrophilic telechelic macromonomer is PEG-diacrylate or PEG-dimethacrylate and the hydrophilic monomer is an acrylic-based monomer. Any biomolecules may be linked to the IPN hydrogels, but are preferably biomolecules that support the growth of cornea-derived cells. The material is designed to serve as a corneal prosthesis.

Described herein are adhesive polymeric compositions and methods for using the compositions. The composition are adherent to the applied surface. The compositions, in certain embodiments, are biodegradable and biocompatible, and can be designed with selected properties of compliancy and elasticity for different surgical and therapeutic applications. The adherent polymeric compositions comprise a polymerized macromer network and an additive mixed or entangled in the polymerized macromer. The additive is bonded to a surface by at least one covalent bond or by secondary interactions and is not covalently bonded to the polymerized macromer network. Alternatively, the additive is bonded to the surface by at least one covalent bond and is also bonded to the macromer network. The disclosed compositions can be used as an improved barrier, coating or drug delivery system that due to the additive is highly adherent to an applied surface. The compositions of the present invention are typically non-toxic, water miscible and have adaptable characteristics depending on the macromers and additives used. For example, specific macromers can be used for targeted bioresorption rate and/or degradation rate of the applied composition.