109results about How to "Fast gelation" patented technology

Hydrogels of polymerized and crosslinked macromers comprising hydrophilic oligomers having biodegradable monomeric or oligomeric extensions, which biodegradable extensions are terminated on free ends with end cap monomers or oligomers capable of polymerization and cross linking are described. The hydrophilic core itself may be degradable, thus combining the core and extension functions. Macromers are polymerized using free radical initiators under the influence of long wavelength ultraviolet light, visible light excitation or thermal energy. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. Preferred applications for the hydrogels include prevention of adhesion formation after surgical procedures, controlled release of drugs and other bioactive species, temporary protection or separation of tissue surfaces, adhering of sealing tissues together, and preventing the attachment of cells to tissue surfaces.

This invention provides for a process of rapidly forming silk fibroin gelation through ultrasonication. Under the appropriate conditions, gelation can be controlled to occur within two hours after the ultrasonication treatment. Biological materials, including viable cells, or therapeutic agents can be encapsulated in the hydrogels formed from the process and be used as delivery vehicles.

This invention provides for a process of rapidly forming silk fibroin gelation through ultrasonication. Under the appropriate conditions, gelation can be controlled to occur within two hours after the ultrasonication treatment. Biological materials, including viable cells, or therapeutic agents can be encapsulated in the hydrogels formed from the process and be used as delivery vehicles.

The utility model relates to a rapid preparation method of SiO2 aerogel sphere, belonging to a field of inorganic metallic materials, in particular to a method of rapidly preparing SiO2 aerogel sphere. Water glass is used as raw material that performs ion exchange to obtain the silicic acid PH=2-3, after added with alkaline catalyst, the silicic acid is added into the hydrophobic oil, and then is mixed to cut into micro liquid drops that are spherically suspended in the oil under the action of surface tension, the silicic acid is mixed until aerogel sphere is generated, afterwards, the oil and the sphere perform solid-liquid separation, and then are cleaned with water to obtain aerogel sphere, the aerogel sphere is soaked by the ethanol and absolute alcohol in sequence to perform solvent exchange to obtain alcohol gel sphere, after dried, aerogel sphere with micrometer or millimeter grade particles can be otained. The invention has low cost, easy and controllable process, mass production, good product quality and wide application prospect in the heat isolation and catalysis fields.

The invention discloses a temperature and ion dual-sensitive in-situ gel nasal cavity drug delivery system, comprising a main drug and a temperature and ion dual-sensitive in-situ gel matrix, wherein the temperature and ion dual-sensitive in-situ gel matrix is mainly prepared from the following raw materials of temperature sensitive in-situ gel matrix, ion sensitive in-situ gel matrix, and a penetration enhancer. The drug delivery system disclosed by the invention is especially suitable for a drug of achieving the central pivot through a BBB (blood brain barrier) to play a role, has good sprayable property and good in-situ gel property and drug slow-release effect, and benefits for playing the drug effect.

The invention relates to a gel hemostatic material and a preparation method thereof. The gel hemostatic material achieves the effect of blocking hemostasis in such a way that a nucleophilic polymer and an amino acid oligomer are in cross-linking reaction with an electrophile polymer to generate a three-dimensional polymer in situ. A gel hemostatic material composition and a preparation method thereof have the advantages that the raw material ratio is controlled accurately, the reasonable gel forming time can be achieved, the gel forming time is less than 10 seconds, the expected strength is relatively high, and the testing result shows that the elongation at break of the biologic gel hemostatic material is 300-600 percent, and the compression strength of the biologic gel hemostatic material is larger than 3 Mpa; the requirement of surgical operation can be met well.

The invention relates to a vessel plug material used in intervene treatment. Wherein, said material is temperature-sensitive nanometer gel system based on polymer N-isopropyl acrylamide (PNIPAAm), which comprises polymer N-isopropyl acrylamide nanometer gel and dispersed medium, while the gel mass percentages is 3-20% and the particle diameter of temperature-sensitive nanometer gel is 50-1000nm. The inventive temperature-sensitive nanometer gel system also can contain developer, soluble antineoplastic. The invention can control the polymer monomer kinds and ratios, the crosslinker amount and the density of temperature-sensitive nanometer gel, to control the sol-gel transformation temperature of said system, and the inventive product has better external flow property and high sol-gel transformation speed, to be used to treat vessel plug, etc.

The invention relates to injectable silk fibroin-alginate double cross-linking hydrogel which comprises a solution A: a silk fibroin solution and a solution B: a modified alginate solution, wherein the solution A comprises the following components in parts by weight: 1.0*10<-1>-3.0 parts of silk fibroin, 1.4*10<-3>-2.0*10<-3> part of a divalent metal ion cross-linking agent, and the balance of water containing 1-5wt% of silk fibroin; the solution B comprises the following components in parts by weight: 5.0*10<-1>-4.0 parts of alginate, 2.5*10<-3>-4.0*10<-1> part of a carboxyl activating cross-linking agent and the balance of water containing 1-5wt% of alginate. By adopting a double cross-linking method of covalent cross-linking and ion cross-linking, the double cross-linking hydrogel is quick to polymerize in situ and has an application prospect in the fields such as engineering stents, drug controlled release and regenerative medicines. The invention further provides a preparation method and a use method of the double cross-linking hydrogel.

A method for preparing a sericin hydrogel, the method including: 1) weighing a cocoon of a fibroin-deficient mutant silkworm, Bombyx mori, extracting the cocoon by an aqueous solution of LiBr or LiCl, dialyzing an extracted solution to yield a sericin solution having a concentration of a non-degraded sericin of between 0.1 and 4 wt. %; and 2) concentrating the sericin solution to a concentration of between 1.5 and 10 wt. %, adding a crosslinking agent to the concentrated sericin solution at a ratio of between 2 and 500 μL of the crosslinking agent per each milliliter of the sericin solution, fully blending the crosslinking agent with the concentrated sericin solution, and keeping a resulting mixture at the temperature of between 4 and 45° C. for between 5 s and 36 hrs to yield a hydrogel.

A 100% solids laminating adhesive for flexible packaging with an improved range of adhesion and bond strength to various substrates along with reduced odor during application and improved ink compatibility and ink bonding. The adhesive is an epoxy-acrylate / amine formulation. Methods of application of the inventive adhesive are also disclosed.

The invention relates to the technical field of biodegradable high-polymer materials, and aims at providing a biodegradable physical hydrogel capable of being rapidly gelatinized in situ and a preparation method of the biodegradable physical hydrogel. The biodegradable physical hydrogel capable of being rapidly gelatinized in situ is composed of a component A aqueous solution and a component B aqueous solution. The preparation method specifically comprises the following preparation steps: by taking stannous octoate as a catalyst, synthesising a component A and a component B through ring-opening polymerization respectively; dissolving the prepared component A and component B in water respectively, then mixing to form a mixed solution and carrying out an oscillation treatment to obtain a stable physical cross-linked hydrogel. The preparation process of the hydrogel disclosed by the invention is simple, and the gelatinization time and the mechanical strength of the hydrogel can be adjusted by changing the ratio of the component A to the component B and a total polymer concentration; the prepared hydrogel is biodegradable, capable of being metabolised by a human body, capable of being rapidly gelatinized in situ without external stimulation, and capable of being used in the biomedical fields of medicine carriers, tissue engineering and the like.

The invention relates to intermolecular Cr 3+ cross-linked polymer gel and a production process. The intermolecular Cr 3+ cross-linked polymer gel comprises the following components which are matched according to mass concentration, wherein partial hydrolysis polyacrylamide is used as host crystal whose concentration range is 0.04%-0.12 %, organic chromium is used as cross linking agent in which the mass concentration of Cr 3+ is calculated based on the mass concentration of polymer, wherein polymer: Cr 3+ = 40:1-100:1, and oil-field produced water or source water is used as solvent. The polymer gel has the characteristics of low viscosity, rapid gel forming speed, large flow resistance and controllable flow ability, which can be used to adjust water injection profile of a water injection well in oil fields which are driven by water, and simultaneously expresses excellent technology and economy.

The invention provides a double stimuli responsive type poly amino acid based supermolecular reverse gel used in the technical field of water gel and a method for preparing the same, wherein the method comprises the following steps of: synthesizing a linear poly(L-benzyl-glutaric acid ester)-polyethylene glycol diblock copolymer; preparing a poly(L-glutamic acid)-polyethylene glycol di-block copolymer used for forming the reverse gel; forming the supermolecular reverse micelle in which the alpha-cyclodextrin-polyethylene glycol complex serves an inner core and the poly(L-glutamic acid) servesa shell; and protonating the poly(L-glutamic acid) chain segments in an acid environment, forming crosslinking by using the mutual action of the hydrogen bonds between the poly(L-glutamic acid) chainsegments, and allowing the supermolecular reverse micelles to mutually gather to form the double stimuli responsive type poly amino acid-based supermolecular reverse gel at room temperature. Comparedwith the prior art, the elastic modulus of the gel is further improved, the gel system prepared by the method is damaged when the pH value of the gel system is higher than 8, the reverse gel can be formed again when the pH value of the gel system is adjusted to be 5, so that the pH value reversibility is good.

The invention discloses a rapidly degradable chemical bond based PEG hydrogel and a preparation method and applications thereof. The hydrogel is formed by respectively connecting a polyethylene glycolderivative 1 (polyethylene glycol amino) with a polyethylene glycol derivative 2 (polyethylene glycol succinimide ester) and a polyethylene glycol derivative 3 (polyethylene glycol aldehyde group) through a chemical bond 1 and a chemical bond 2; and the chemical bond 1 is beta-carbonyl amide bond, and the chemical bond 2 is schiff base bond. The PEG hemostasis sealing hydrogel has potential applications in the following fields: drug slow releasing materials; tissue engineering scaffolds; medical sponges; visceral organ hemostatic sealants; surface coatings of medical implants; epidermis hemostatic sealing coatings; coatings for burn treatment; and tissue adhesion preventing materials. The gelation speed of the PEG hemostasis sealing hydrogel is fast; the hydrogel can be rapidly formed onthe surfaces of objects and rapidly degraded in the body and on the body surfaces; the hydrogel has excellent hemostasis effects and good biocompatibility, and can be rapidly cleared (disappeared).

The invention discloses anhydrous fracturing fluid suitable for unconventional reservoir fracturing. The anhydrous fracturing fluid comprises, by mass, 1.0-2.0% of gelling agent, 2.0-4.0% of micelle accelerant, 0.1-0.5% of temperature stabilization agent and the balance alkyl hydrocarbon. The temperature stabilization agent is sulfamic acid or dodecylbenzene sulfonic acid, the alkyl hydrocarbon is one kind or more kinds of propane, butane and pentane, the gelling agent is dialkyl group phosphate ester iron, and the micelle accelerant is an organic complex containing trivalent metal ions. The invention further discloses a preparing method of the anhydrous fracturing fluid. The gelling agent is liquid at the normal temperature and is good in liquidity, the fracturing fluid is simple in preparing technology, the glue forming speed is controllable, the fracturing transformation of shale beds below 130 DEG C can be met, a gel breaker is not needed, the fracturing fluid is gasified under the formation temperature and the pressure and can be recycled after begin discharged out of the ground through a well pipe, external discharge and pollution of waste liquid are avoided, and the anhydrous fracturing fluid has the advantages of being environmentally friendly and the like.

The invention provides a polyethylene glycol derivative, which comprises a repeating unit with a structure represented by a formula (I) and an end group with a structure represented by a formula (II).The polyethylene glycol derivative provided by the invention has good biocompatibility due to the repeating unit with the structure represented by the formula (I). Due to the fact that the o-phthalaldehyde terminal group with the structure represented by the formula (II) can react with various groups such as amino, (acyl) hydrazine, amido-oxy and the like, the reaction speed is high, and the reaction conditions are mild. The polyethylene glycol derivative provided by the invention and amino-terminated polyethylene glycol are mixed in an aqueous medium to quickly form a chemically cross-linkedhydrogel material, and the chemically cross-linked hydrogel material has the advantages of mild preparation conditions, high gelling speed, high mechanical strength and good stability. The polyethylene glycol hydrogel can be used as a drug sustained-release carrier or a tissue engineering scaffold and the like to be applied to the field of biomedical materials.

The present invention relates to biocompatible crosslinked biomaterials made from polycondensation polymerization reactions involving polynucleophilic-polyelectrophilic precursors that address the limitations of steric hindrance, viscosity, and diffusion currently reducing gelation rates and curing thoroughness of the biomaterials. A cross-linking scheme is utilized in the invention that permits rapid gelation and thorough curing of the biomaterial. The biomaterial is made by polycondensation polymerization of polynucleophilic-polyelectrophilic precursors to form a water-soluble polymer crosslinked with a water-soluble crosslinker having at most one core cyclic structure.

The invention relates to the technical field of biomedical polymer material, and provides an injectable hydrogel material for solving the problems that existing injectable hydrogel is slow in condensation, low in strength, and poor in biocompatibility and biodegradability, and consequently fixed point forming and long-term exercise tolerance of the hydrogel after injection are not facilitated. Theinjectable hydrogel material is generated from a component A and a component B in-situ through isovolumetric injection by adopting dual-linking injection technology; and the component A is carboxymethyl chitosan, and the component B is prepared from reaction of double hydroformylation polysaccharide and an auxiliary cross-linking agent and a formylation contrast agent. According to the injectablehydrogel material, the exercise tolerance is good, the requirements of the biocompatibility and the biodegradability are met, the functions of multimoding development and controlled degradation are further achieved, the effect that the multiple functions of protection, tracing, customized treatment and the like are integrated is achieved, and the wide application prospects in the field of integration of diagnosis and treatment are achieved.

A manufacturing method includes: inducing gelation of an electrically conductive polymer to form a gel; infiltrating the gel with a solution including monomers; and polymerizing the monomers to form a secondary polymer network intermixed with the electrically conductive polymer.

The invention relates to the field of building materials, in particular to a method for preparing a building cementing material from electrolytic manganese metal leaching residues. According to the method, the electrolytic manganese metal leaching residues are treated by adopting concentrated sulfuric acid; sulfate slag and acid-leached electrolytic manganese metal liquid are generated; by removing various metals from the acid-leached electrolytic manganese metal liquid, composite aluminum iron phosphate, copper-cobalt-nickel sulfide concentrate, manganese carbonate concentrate and ammonia water are effectively recovered and mixed with the sulfate slag, the mixture is reacted with calcium hydroxide generated by reacting quick lime and water, and mixed with Portland cement to generate the cementing material; the activity of the electrolytic manganese slag is improved, and the gelling property of the electrolytic manganese slag can be fully excited; the prepared building cementing material can be prepared into cement masonry mortar, plastering mortar, dry-mixed mortar, exterior wall plastering mortar, baking-free bricks and the like, the mixing amount of cement in the cementing material is reduced, the setting time of the cementing material can be adjusted, the strength is high, the cementing material is healthy and environmentally friendly, the cost is reduced, and the economicbenefits of enterprises are improved.

The invention discloses in-situ crosslinking shaping medical sealing glue capable of promoting wound healing and a preparation method thereof. The medical sealing glue has the gelling time being 1 to10s, the swelling degree being 0 to 100 percent, the cracking intensity being 100 to 250mmHg and the degradation time being 0.5 to 300 days. The medical sealing glue is prepared from two ingredients through being physically mixed by a mixing tool and then being subjected to covalent cross-linking; a first ingredient is a nucleophilic ingredient; a second ingredient is an electrophilic ingredient.The medical nucleophilic ingredient contains exosomes or hyaluronic acid and chitosan, so that the medical sealing glue has the effect of promoting the wound healing; the antibacterial and anti-infection effects are achieved.

The invention belongs to the field of underground construction, and particularly discloses an early-strength shield wall post-grouting formula. The early-strength shield wall post-grouting formula comprises the following substances in parts by weight: 800 to 1000 parts of fine sand, 35 to 50 parts of bentonite, 110 to 220 parts of coal ash, 400 to 600 parts of Portland cement, 70 to 100 parts of gypsum, 5 to 8 parts of an early strength agent and 400 to 600 parts of water. The early-strength shield wall post-grouting formula has relatively high condensation rate, and also has the characteristic of high early strength; and moreover, the long-term strength and shear resistance of the grouting are further effectively guaranteed, ground deformation and duct piece floating are controlled, and the damage of duct pieces is reduced.

A 100% solids laminating adhesive for flexible packaging with an improved range of adhesion and bond strength to various substrates along with reduced odor during application and improved ink compatibility and ink bonding. The adhesive is an epoxy-acrylate / amine formulation. Methods of application of the inventive adhesive are also disclosed.

The invention relates to a method for preparing an absorbent resin. The method is characterized by comprising the following steps of: (1) preparing a gel product, wherein the gel product is prepared by mixing various vinyl monomers and a primary cross-linking agent in water, neutralizing the mixture by using alkaline solution and performing polymerization initiated by using hyperoxide; (2) cutting, drying and crushing the gel product to obtain the crude absorbent resin; and (3) performing secondary cross-linking treatment on the crude absorbent resin to obtain the absorbent resin. The absorbent resin of the invention has the advantages of high water absorbing capacity, thermal stability and bonding performance with coals.

The invention discloses a chitosan-based pure physically-crosslinked dual-network hydrogel and a preparation method thereof. With the method provided by the invention, a double-network hydrogel crosslinked by pure physical action is constructed by using chitosan and succinylated chitosan as raw materials and an alkaline solvent system as a basis; and the obtained hydrogel is further subjected to biomimetic mineralization to improve mechanical properties. Compared with a pure chitosan hydrogel, the chitosan-based pure physically-crosslinked double-network hydrogel provided by the invention is regular and compact in structure, and is significantly improved in the mechanical properties. Meanwhile, compared with a traditional chemically-physically crosslinked chitosan-based double-network hydrogel, the chitosan-based pure physically-crosslinked dual-network hydrogel has obvious advantage in good biocompatibility. The pure physically-crosslinked double-network hydrogel prepared by using thepreparation method provided by the invention has good mechanical properties and good biocompatibility, and has good application prospect in the field of biomedicine application.

The invention discloses a magnetic rare earth barium ferrite nano purifying catalyst, as well as a preparation method and application thereof. The catalyst is used for waste water treatment. The general formula of the catalyst is BaxReyMezFemOn, wherein x is 0.1-3.0, y is 0-2.0, z is 0-2, m is 1-24, n is 3-48, Me is Cu, Zn, Mn or Co, and Re is La, Ce, Nd, Pr, Sc or Y. The preparation method comprises the following steps: dissolving to prepare a solution, matching, mixing, carrying out high temperature ultrasonic dispersion for solation, carrying out microwave vacuum for gelation, carrying out microwave vacuum for denitration with less oxygen, and roasting; the method is characterized in that the high temperature ultrasonic dispersion, the microwave vacuum for gelation, the microwave vacuum for denitration with less oxygen and the roasting processes are performed after the matching and mixing processes. According to the invention, microwave vacuum for denitration with less oxygen is adopted to enable ammonium nitrate to be directly transformed into nitrogen, oxygen and water, no nitrogen oxide is generated during the preparation process, and secondary pollution caused by nitrogen oxide generated during a traditional preparation process is eliminated.

The invention discloses a self-repairing fast sealing medical adhesive and a production method thereof. The medical adhesive is formed by conducting covalent cross-linking after two components are subjected to physical mixing through a mixing tool, wherein the first component is composed of aldehyde group macromolecules subjected to esterification modification, and the second component is composedof amino-modified macromolecules. According to the self-repairing fast sealing medical adhesive and the production method thereof, by adjusting a ratio of esterification groups to aldehyde groups toamino groups and concentrations of the esterification groups, the aldehyde groups and the amino groups, the adhesive forming time, the rupture strength and adhesion to wounds of the medical adhesive can be adjusted. According to the self-repairing fast sealing medical adhesive and the production method thereof, by adjusting concentrations of the first component and the second component, the viscosity and the density of the medical adhesive before the medical adhesive is formed can be adjusted so that blood effects can be reduced. The medical adhesive has a high amino group content, and thus has certain bacteriostatic ability. When the medical adhesive is formed, dynamic bonds can be formed, so that the medical adhesive has a certain self-repairing function. Therefore, the medical adhesivehas the efficacy of fast efficient hemostasis, self-repairing and baceriostasis.

A catalyst curing system or hardener for resorcinolic resins, such as resorcinol-formaldehyde or phenol-resorcinol-formaldehyde resins including methylolurea. The methylolurea may be used in combination with oxazolidine in ratios ranging from 5:95 to 95:, by molar basis. The hardener crosslinks the resins which permits reduction or "fuming" of formaldehyde as well as control of gel times of the resulting adhesive. The hardener of the present invention if of particular utility in adhesives for use in the forest products industry.

The present invention provides a biological scaffold and a preparation method and an application thereof. The biological scaffold comprises a biological matrix and long-chain DNA entangled in the biological matrix. The biological scaffold is of a pore structure. The biological scaffold of the present invention adopts the biological matrix as the main scaffold material, and the long-chain DNA entangled in the biological matrix as a mechanical lock for locking biological matrix fiber. Sol containing a large amount of monodisperse droplets is rapidly gelated under the action of a shear force, soas to shorten gelation time of natural biological matrix and increase gelation speed by 10-100 times. The pore structure promotes the exchange of substances in the biological matrix, provides oxygen and nutrients to cells, discharges metabolic wastes, and improves survival rate of cell transplantation.

The invention discloses a method for preparing an enzymic method modified whey protein soluble polymer and belongs to the field of protein preparation. The preparation method comprises the following steps: preparing a 10% whey protein solution; heating the solution for 5 min at the temperature of 85 DEG C and cooling to room temperature; adding glutamine transaminase (TG) to modify; and heating for 5 min at the temperature of 85 DEG C, inactivating the TG, and cooling to room temperature to obtain the whey protein soluble polymer (WPSA). Based on a single factor experiment result, the horizontal setting scope of each factor of the experiment is determined and an orthogonal experiment is processed. The optimum enzyme dose, the reaction temperature, the reaction time and the pH value of the WPSA are finally determined. The obtained soluble polymer is rapid in gelatinization speed, high in viscosity and easy to gelate. The influences of the soluble polymer formed by catalyzing the whey protein by TG under different reaction conditions are researched and the optimum condition for preparing the WPSA is modified. The whey protein soluble polymer produced by the method provided by the invention is transparent in appearance, appropriate in viscosity, easy to apply, stable and high in gel property.