Chitosan-based pure physically-crosslinked double-network hydrogel and preparation method thereof

A technology of chitosan and hydrogel, which is applied in the field of chitosan-based pure physical cross-linked double network hydrogel and its preparation, can solve the problems of weak physical cross-linking, achieve the goal of improving mechanical properties and wide application prospects Effect

Active Publication Date: 2020-02-21
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few reports on macromolecular double network hydrogels formed only by pure physical effects, mainly because the force of physical crosslinking is much weaker than that of chemical crosslinking, and it is still a huge challenge to achieve a substantial improvement in material performance. challenge

Method used

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  • Chitosan-based pure physically-crosslinked double-network hydrogel and preparation method thereof
  • Chitosan-based pure physically-crosslinked double-network hydrogel and preparation method thereof
  • Chitosan-based pure physically-crosslinked double-network hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1) First weigh a certain amount of lithium hydroxide monohydrate and urea and dissolve them in deionized water to form a clear solution, wherein the weight fractions of lithium hydroxide and urea are 3% and 6% respectively, and use this solution as the sample for subsequent experiments Alkaline solvent system;

[0030] 2) take by weighing 1 gram of succinylated chitosan (molecular weight 100000, succinylation degree 85%) powder and join in the alkaline solvent prepared in step 1), stir for 30 minutes, then weigh 6 gram of chitosan ( Molecular weight 2,000,000, degree of deacetylation 95%) was added in the above-mentioned solution, stirred again for 30 minutes, and was mixed with a 3% solution of succinylated chitosan / chitosan mass fraction;

[0031] 3) The mixture prepared in step 2) was repeatedly frozen (-80°C)-thawed (30°C), and kept stirring during the thawing process. After freezing-thawing was repeated 3 times, a more transparent succinylated Chitosan / chitosan al...

Embodiment 2

[0037] 1) First, a certain amount of lithium hydroxide monohydrate and urea were weighed and dissolved in deionized water to form a clear solution, wherein the weight fractions of lithium hydroxide and urea were 9% and 12% respectively, and this solution was used as a sample for subsequent experiments. Alkaline solvent system;

[0038] 2) take by weighing 1 gram of succinylated chitosan (molecular weight 20000, degree of succinylation 90%) powder and join in the alkaline solvent prepared in step 1), stir for 60 minutes, then weigh 5 gram of chitosan ( Molecular weight 5000000, degree of deacetylation 80%) is added in the above-mentioned solution, stirs again 10 minutes, is mixed with the solution that succinylated chitosan / chitosan mass fraction is 2%;

[0039] 3) The mixture prepared in step 2) was repeatedly frozen (-60°C)-thawed (20°C), and kept stirring during the thawing process. After freezing-thawing was repeated 5 times, a more transparent succinylated Chitosan / chitos...

Embodiment 3

[0045] 1) First weigh a certain amount of lithium hydroxide monohydrate and urea and dissolve them in deionized water to form a clear solution, wherein the weight fractions of lithium hydroxide and urea are 6.3% and 9.5% respectively, and use this solution as the sample for subsequent experiments. Alkaline solvent system;

[0046] 2) take by weighing 1 gram of succinylated chitosan (molecular weight 500000, degree of succinylation 80%) powder and join in the alkaline solvent prepared in step 1), stir for 40 minutes, then weigh 4 gram of chitosan ( Molecular weight 200000, degree of deacetylation 95%) is added in the above-mentioned solution, stirs again 20 minutes, is mixed with the solution that succinylated chitosan / chitosan mass fraction is 5%;

[0047] 3) The mixture prepared in step 2) was repeatedly frozen (-70°C)-thawed (25°C), and kept stirring during the thawing process. After freezing-thawing was repeated 4 times, a more transparent succinylated Chitosan / chitosan al...

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Abstract

The invention discloses a chitosan-based pure physically-crosslinked dual-network hydrogel and a preparation method thereof. With the method provided by the invention, a double-network hydrogel crosslinked by pure physical action is constructed by using chitosan and succinylated chitosan as raw materials and an alkaline solvent system as a basis; and the obtained hydrogel is further subjected to biomimetic mineralization to improve mechanical properties. Compared with a pure chitosan hydrogel, the chitosan-based pure physically-crosslinked double-network hydrogel provided by the invention is regular and compact in structure, and is significantly improved in the mechanical properties. Meanwhile, compared with a traditional chemically-physically crosslinked chitosan-based double-network hydrogel, the chitosan-based pure physically-crosslinked dual-network hydrogel has obvious advantage in good biocompatibility. The pure physically-crosslinked double-network hydrogel prepared by using thepreparation method provided by the invention has good mechanical properties and good biocompatibility, and has good application prospect in the field of biomedicine application.

Description

technical field [0001] The invention belongs to the field of biomedical hydrogels, in particular to a chitosan-based purely physically cross-linked double network hydrogel and a preparation method thereof. Background technique [0002] Hydrogel is a material with a three-dimensional network structure, which has a series of characteristics, including easy-to-adjust physical and chemical properties, manufacturing diversity, etc., especially biological characteristics and similarity with extracellular matrix, making hydrogel Become one of the most promising materials in the field of biomedicine. Double network hydrogel is a new type of hydrogel, in which two macromolecules interact to form a three-dimensional network structure, and the synergistic effect between the two can improve its performance, which can significantly strengthen and toughen the hydrogel. However, most of the current double network hydrogels are formed by pure chemical cross-linking or physical-chemical cro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/24C08L5/08
CPCC08J3/075C08J3/245C08J2305/08C08J2405/08
Inventor 王征科乔丰慧裴伯映胡巧玲
Owner ZHEJIANG UNIV
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