31results about How to "Does not affect biocompatibility" patented technology

The invention discloses a silk fibroin gel microneedle system and a manufacturing method of the silk fibroin gel system microneedle system. Silk fibroin solution with the mass concentration between 3 percent to 15 percent is processed through ultrasonic oscillation and then is poured on a polydimethylsiloxane film needle hole die array obtained through laser boring, dies are placed in a vacuum drying box and vacuumized, the solution is made to enter holes, the vacuum degree is kept, the dies are dried to constant weight, and then the silk fibroin gel microneedle system is obtained. The microneedle system is an insoluble gel microneedle and has certain brute force to puncture into the skin, the microneedle system swells after making contact with body fluid in the skin, and medicine in the microneedle system is released. The gel microneedle system is good in biocompatibility, easy to prepare, moderate in condition and capable of biodegradation, and the system can be used in the aspects of cosmetology, transdermal drug absorption devices and the like.

The invention relates to a preparation method for paclitaxel coating on the surface of a drug balloon. The preparation method comprises the steps that a hydrophilic balloon surface is pretreated; the balloon surface is coated with a first organic solution to obtain a modified balloon, wherein the first organic solution contains both a hydrophilic group and a lipophilic group; and the modified balloon is immersed into a paclitaxel coating solution, placed into a low-temperature device to be frozen for a period of time and then is dried, and the crystallization process is repeatedly executed. The preparation method for the paclitaxel coating solution comprises the step of dissolving paclitaxel and a carrier into a second organic solution according to the certain mass percentage, wherein the carrier has the effect of increasing the paclitaxel dissolvability. The preparation technology is simple and reliable, and is low in cost. The preparation method allows precise control of the drug loading capacity of the paclitaxel coating on the surface of the drug balloon and is beneficial to mass production.

The invention discloses a hydroxyapatite/aluminum oxide composite bioceramic and a preparation method thereof, relating to the field of biomaterials. The hydroxyapatite/aluminum oxide composite bioceramic is prepared from the following components in parts by mass: 40-60 parts of hydroxyapatite, 10-20 parts of shell powder, 15-25 parts of nano aluminum oxide, 5-12 parts of zirconium oxide, 3-8 parts of magnesium oxide, 5-10 parts of calcium hydrogen phosphate and 2-5 parts of nano zinc oxide. The preparation method comprises the following steps: (1) weighing; (2) ball milling; (3) cold-press molding; (4) high-temperature calcination; and (5) cooling. The hydroxyapatite/aluminum oxide composite bioceramic has higher biocompatibility, maintains the excellent actions of the hydroxyapatite, further enhances the mechanical properties of the bioceramic, and thus, is a very ideal skeleton substitute repair material.

The invention discloses a multifunctional bone filling material containing black phosphorus nanosheets and a preparation method thereof. The multifunctional bone filling material is prepared from black phosphorus nanosheets, nano magnesium oxide, polyvinyl alcohol and chitosan. The specific preparation method comprises the following steps: preparing black phosphorus nanosheets; preparing a polyvinyl alcohol and chitosan hydrogel compound; loading the black phosphorus nanosheets and a nano magnesium oxide hydrogel compound, and the like. The multifunctional hydrogel bone filling stent disclosedby the invention overcomes the defects of poor complex disease resistance and poor osteogenesis induction of a stent system in the prior art, and the progress of bone defect repair under complex disease conditions is improved effectively.

The invention discloses a preparation method of a microsphere close-packed shape memory porous scaffold. Medicine delivery and a porous structure are formed in a material with a shape memory function under the action of a pore-foaming agent and a medicine, so as to prepare the porous scaffold with the shape memory function and the medicine function. A porous scaffold material loaded with medicine factors is prepared by (1) preparation of drug-loaded calcium alginate hydrogel microspheres, and (2) preparation of the porous structure; the prepared porous scaffold has a good shape memory property, biocompatibility and biodegradability, also has a drug release effect, and has a great application prospect in the field of tissue engineering. An experiment proves that the preparation method has the advantages of controllable aperture, uniform dimension and the like, and does not need to sacrifice a pore-forming material; and the raw materials are cheap and easily available.

A process for preparing artificial eye ball includes such steps as dissolving the biocompatible polymer in solvent to obtain saturated solution, mixing it with sieved pore-forming agent (300-600 microns), die pressing to obtain circular ball, volatilizing solvent, immersing the ball in the swelling solution prepared from trigger, cross-linking agent and polymer monomer, introducing nitrogen gas, sealing, swelling for 3-100 hr, putting the ball in reactor, introducing nitrogen gas, sealing, polymerizing, and immersing the ball in deionized water for 72 hr. Its advantages are high precision of size, high porosity (more than 80%), and high performance.

The invention provides a magnesium alloy medical implant and a preparation method thereof, and the preparation method comprises the following steps: providing a magnesium alloy which comprises magnesium and at least one active element; the magnesium alloy is sequentially subjected to thermal oxidation treatment and post-treatment, the magnesium alloy medical implant is obtained, and the magnesium alloy medical implant comprises an oxide passivation layer, a middle layer and a magnesium alloy base body. The magnesium alloy medical implant has a customized appearance matched with bone defects and a composite structure comprising the oxide passivation layer on the surface, the middle layer and the magnesium alloy base body, the oxide passivation layer and the middle layer are degraded slowly in body fluid, the magnesium alloy base body is separated from the body fluid, the degradation rate of the magnesium alloy medical implant is decreased, and the service life of the magnesium alloy medical implant is prolonged. The degradation period is matched with bone tissue reconstruction and functional recovery, and the bone defect repair effect is improved. The preparation method is not influenced by geometric structures, no other materials are added, the degradation period is adjustable, the effect is stable, operability is high, and industrial production and clinical application are facilitated.

The invention discloses a zirconia biological ceramic used for making hip joint and a preparation method thereof, and relates to the field of biological materials, the zirconia biological ceramic used for making the hip joint comprises the following components by mass: 65-85 parts of zirconia, 3-7 parts of nano titanium oxide, 2-8parts of nano aluminum, 1-3 parts of nano zinc oxide, 2-5 parts of carbon fiber and 5-10 parts of calcium oxide. The preparation steps of the preparation method of the zirconia biological ceramic used for making the hip joint are as follows: (1) weighing; (2) ball milling; (3) cold pressing molding; (4) high temperature calcination, and (5) cooling. The zirconia biological ceramic used for making the hip joint has high wear-resisting property and toughness, and good biological compatibility, and has good application prospect as a material for making the hip joint.

The invention belongs to the technical field of biological materials, and particularly relates to a paint for a medical instrument, and a preparation method and application thereof. The paint comprises the following components: metal salt, polyphenol and an oxidizing agent, wherein the metal salt is selected from zinc salt and strontium salt. The medical instrument comprises a base material and a coating on the surface of the base material; and the coating is formed by the paint. The paint is applied to medical instruments through interaction of the zinc salt, the strontium salt, the polyphenol and the oxidizing agent, and has the advantages of uniform film formation, no influence on the biocompatibility of the base material, improvement of the antibacterial property and the osteogenesis promoting effect, wide application range, simple and convenient preparation process, good repeatability, strong controllability and the like.

The invention provides a titanium alloy packing barrel manufacturing technology. The surface of a titanium barrel body is subjected to nylon wheel rough polishing, felt wheel finishing polishing and yellow cloth wheel super-finishing polishing in sequence, there are no defects, such as scratches, blisters, piebald and bastard cut, on the surface of the titanium barrel body, a full-mirror effect isachieved, the uniformity of the polishing quality is improved, the technical steps are simple, the technology is easy to implement, and the polishing efficiency is high. For the treatment of the internal surface of the titanium barrel body, the internal surface is subjected to cleaning by using a cleaning solution, washing with RO ultrapure water, drying, electrolysis by using an electrolytic polishing solution and washing with RO ultrapure water in sequence, it is ensured that the impurities and oil contaminations on the internal surface of the titanium alloy barrel body are removed thoroughly, and the aim that the surface is super clean is achieved; afterwards, through oxidation treatment, a dense oxidation layer is naturally formed on the internal surface of the titanium alloy barrel body, the corrosion resistance of the titanium barrel is improved, and the service life of the titanium barrel is prolonged.

The present invention relates to medicine. Of the antisticking particle and powder, the main component is sodium hyaluronate, which is also named as sodium hyaluronate and may be also compounded into compounded preparation with other separating agent and pharmacological active matters, such as anticoagulant, antiphlogistic, calcium passage retarder, cytostatic agent and proteolytic enzyme. The antisticking particle and powder of the present invention consists of sodium hyaluronate 1-100 wt%, separating agent 0-99 wt% and active component in the amound based on relevant pharmacopeia. The antisticking particle and powder of the present invention is used for antisticking after operation in abdominal cavity, gynaecological and obstetrical operation, orthopedical operation and thoracic operation and has excellent antisticking effect.