Method for preparing oriented interconnected porous biomedical scaffold, scaffold prepared therefrom, and use of the scaffold in the preparation of medical products

Abstract

The invention discloses a method for preparing a polycaprolactone oriented interconnected porous biomedical stent, which comprises the following steps: (1) melting and blending polycaprolactone and polyethylene oxide to obtain a co-continuous blend, the blend Continuous blend compression molding obtains polycaprolactone / polyethylene oxide co-continuous substrate; (2) polycaprolactone / polyethylene oxide co-continuous substrate obtained in step (1) is extracted with water to Removing the water-soluble polyethylene oxide phase to obtain a polycaprolactone porous scaffold; (3) stretching the polycaprolactone porous scaffold obtained in step (2) in the solid phase, so that the pore morphology is oriented and deformed along the stretching direction , to obtain polycaprolactone aligned porous biomedical scaffold. The polycaprolactone oriented interconnected porous biomedical scaffold prepared by it presents an obvious highly interconnected and anisotropic porous structure. The invention also discloses the polycaprolactone orientation interconnected porous biomedical support and the use of the support in preparing medical products.

Description

technical field [0001] The invention belongs to the field of tissue engineering biomedical scaffolds, in particular, the invention relates to a preparation method of an orientation-connected porous biomedical scaffold, the prepared scaffold and the use of the scaffold in the preparation of medical products. Background technique [0002] With the aging of the population and the diversification of exercise methods, tissue damage has become one of the most common diseases that endanger human health and normal life. Nowadays, tissue engineering is mainly used for treatment. Tissue engineering research is one of the important components of modern biomedical engineering technology. The use of suitable biological scaffolds is of great significance for the regeneration and repair, reorganization and regeneration of organs and tissues (Czernuszka J T, et al.European cells&materials2003,5(5 ), 29; O'Brien F J, et al. Materials Today 2011, 14(3), 88). At present, it is generally belie...

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Problems solved by technology

However, the microtubular pores of the porous scaffold prepared by this method are only connected by micropores, the connectivity is poor and the pore structure is incomplete, resulting in poor mechanical properties (<1MPa), and the introduction of organic solvents during the preparation process will also affect the scaffold itself. Biocompatibility (Yang DZ, etal. Materials Letters 2018, 233, 78)

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