5163 results about "Lactone" patented technology

The present invention provides bioactive polymer compositions that can be formulated to release a wound healing agent at a controlled rate by adjusting the various components of the composition. The composition can be used in an external wound dressing, as a polymer implant for delivery of the wound healing agent to an internal body site, or as a coating on the surface of an implantable surgical device to deliver wound healing agents that are covalently attached to a biocompatible, biodegradable polymer and/or embedded within a hydrogel. Methods of using the invention bioactive polymer compositions to promote natural healing of wounds, especially chronic wounds, are also provided. Examples of biodegradable copolymer polyesters useful in forming the blood-compatible, hydrophilic layer or coating include copolyester amides, copolyester urethanes, glycolide-lactide copolymers, glycolide-caprolactone copolymers, poly-3-hydroxy butyrate-valerate copolymers, and copolymers of the cyclic diester monomer, 3-(S)[(alkyloxycarbonyl)methyl]-1,4-dioxane-2,5-dione, with L-lactide. The glycolide-lactide copolymers include poly(glycolide-L-lactide) copolymers formed utilizing a monomer mole ratio of glycolic acid to L-lactic acid ranging from 5:95 to 95:5 and preferably a monomer mole ratio of glycolic acid to L-lactic acid ranging from 45:65 to 95:5. The glycolide-caprolactone copolymers include glycolide and ε-caprolactone block copolymer, e.g., Monocryl or Poliglecaprone.

Absorbable polyurethanes, polyamides and polyester urethanes prepared from at least one compound selected from:

or the diamines and diisocyanates thereof, wherein each X represents a member independently selected from —CH₂COO— (glycolic acid moiety), —CH(CH₃)COO— (lactic acid moiety), —CH₂CH₂OCH₂COO— (dioxanone), —CH₂CH₂CH₂CH₂CH₂COO— (caprolactone moiety), —(CH₂)_yCOO— where y is one of the numbers 2, 3, 4 or 6-24 inclusive, and —(CH₂CH₂O)_z′CH₂COO— where z′ is an integer between 2 and 24, inclusive; each Y represents a member independently selected from —COCH₂O— (glycolic ester moiety), —COCH(CH₃)O— (lactic ester moiety), —COCH₂OCH₂CH₂O— (dioxanone ester), —COCH₂CH₂CH₂CH₂CH₂O— (caprolactone ester), —CO(CH₂)_mO— where m is an integer between 2, 3, 4 or 6-24 inclusive, —COCH₂O(CH₂CH₂O)_n— where n is an integer between 2 and 24, inclusive; R′ is hydrogen, benzyl or an alkyl group, the alkyl group being either straight-chained or branched; p is an integer between 1 and 4, inclusive; and Rn represents one or more members selected from H, alkoxy, benzyloxy, aldehyde, halogen, carboxylic acid and —NO₂, which is attached directly to an aromatic ring or attached through an aliphatic chain. Absorbable polymers prepared from these compounds are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention and other implantable medical devices.

An adhesion-preventive film is provided that is excellent in flexibility and can prevent cracks from occurring. The adhesion-preventive film contains a copolymer of lactide and caprolactone. The lactide and the caprolactone of the copolymer has a mole ratio in the range of 65:35 to 80:20. Even when this adhesion-preventive film is used in a curved state in vivo or is wound around an affected part such as a tendon, for example, it can provide an adhesion-preventive function for a sufficiently long period without cracking.

A process for producing high yields of gamma -hexalactone and 2-pentanone from the corresponding hexanoic acid starting material is carried out with high amounts of oxygen and sugar in the presence of a mold microorganism. Fragrance compositions and foodstuff compositions are augmented and enhanced by the presence of the product compounds.

The invention relates to a method for preparing caprolactone through cyclohexanone catalytic oxidation. The method comprises the following steps that: raw materials, namely cyclohexanone, oxidant, solvent and catalyst, are respectively added to a reaction vessel; the reaction vessel is heated to at a temperature between 40 and 100 DEG C; constant temperature reaction is carried out for 1-15 hours; after the reaction is finished, the raw materials are cooled and separated, and then a finished product of caprolactone can be obtained, wherein the catalyst contains 50-100 percent of zinc oxide and 50-0 percent of other metallic oxide in weight percentage; the solvent is nitrile; the oxidant is hydrogen peroxide or peracetic acid. High caprolactone yield and selectivity can be obtained by adopting the method provided by the invention; meanwhile, the catalyst used in the method is low in price, easy to get and simple to prepare, contains no halogen element, has high stability, and can be used repeatedly.

A powder composition comprising, a copolymer containing (A) an organopolysiloxane monomer, one or more kinds of monomer selected from a group composed by (B) a monomer containing nitrogen group, a monomer possessing a polyoxyalkylene group, a monomer possessing a polylactone group, a monomer possessing a hydroxyl group and a monomer possessing an anionic group and a powder. Further, a powder dispersion in oil comprising said copolymer, powder and oil, and a cosmetic composition containing them. Said powder composition and a powder dispersion in oil have a less cohesion of powder particles and is superior in a dispersing ability and a dispersion stability, and the cosmetic composition which contains said powder composition has a good stability and gives an excellent sensation at the actual use.

The object is to provide a polyimide ink composition having good printing properties and good continuous printing properties, which composition can be dried at a low temperature of not higher than 220° C., and which composition gives a coating film, after being dried, having excellent dimensional stability, heat resistance, low modulus of elasticity, flexibility, resistance to warping, chemical resistance, adhesiveness with substrates, and plating resistance. This object is accomplished by a polyimide ink composition for printing, comprising a mixed solvent containing an benzoic acid ester solvent and a glyme solvent, and a polyimide soluble in the mixed solvent; wherein the polyimide is obtained by polycondensing a polyimide oligomer with a tetracarboxylic dianhydride component(s) and/or a diamine component(s) having no siloxane bond in molecular skeleton thereof the polyimide oligomer being prepared by polycondensing a tetracarboxylic dianhydride component(s) and a diamine component(s) having siloxane bonds in molecular skeleton thereof in the presence of a base catalyst(s), or a mixed catalyst including a lactone(s) and/or an acidic compound(s) and a base(s); the content of the diamine component(s) having siloxane bonds based on the total diamine components being 15 to 85% by weight.

The present invention relates to a nanoparticle composition comprising a camptothecin derivative, solid polyethyleneglycol and an anti-associative agent, and the process for preparing the same. Specifically, the present invention provides a composition comprising a nanoparticle of the camptothecin derivative, which is prepared by solid-dispersing the poorly water soluble camptothecin derivative in polyethyleneglycol and dissolving the solid dispersions in an aqueous solution containing an anti-associative agent. The composition of the present invention stabilizes the camptothecin derivative lactone form in body fluid for effective anticancer activity.

A medicine eluted cardiovascular frame is composed of expandible support and the medicine coated biodegradable layer coated on the said frame. The said biodegradable material contains one of the homopolymer and copolymer of glycollide, L-lactide or epsilon-caprolactone, and the copolymer of multi-group amino acids. The medicine can resist the cardiovascular narrowness. The process for preparing the said support includes such steps as preparing the said expandible support, immersing it in the mixture of the said medicine, biodegradable material and solvent, and drying. It can prevent thrombosis.

A positive resist composition comprises: (A) a resin that contains a repeating unit (A1) having a lactone structure and a cyano group, and increases its solubility to an alkali developer by action of an acid; (B) a compound that generates an acid by irradiation with actinic ray or radiation; and (C) a solvent.

The present invention is directed to an oxygen scavenger composition comprising a mixture of (i) a polyester polymer composed of polymer segments containing cycloalkenyl group or functionality; and (ii) an ester type polymer selected from (a)a polyester having a high content of alkylene groups; (b) a polylactone; and (c) a polyvinylacetate having at least about 50 weight percent vinyl acetate mer units therein. The present polymer composition has been found to act as an oxygen scavenger agent under both ambient and refrigerated conditions, to be compatible with conventional film forming packaging materials, to provide compositions exhibiting low tack, and to be capable of being readily processed using conventional film forming equipment.

Provided are a leave-on hair cosmetic composition, containing the following components (A), (B) and (C): (A) an organic dicarboxylic acid or salt thereof, (B) an organic solvent selected from aromatic alcohols, N-alkylpyrrolidones, alkylene carbonates, polypropylene glycols having a number average molecular weight of from 100 to 1000, lactones and cyclic ketones, and

(C) an organopolysiloxane having an organopolysiloxane segment and a poly(N-acylalkyleneimine) segment having a recurring unit represented by the following formula (1):

(wherein, R¹:H, C_1-22 alkyl, cycloalkyl, aralkyl or aryl, and n: 2 or 3), wherein the latter segment has been bonded to at least one silicon atom of the former segment via a hetero-atom-containing alkylene group; having the organopolysiloxane segment and the poly(N-acylalkyleneimine)segment at a weight ratio of from 98/2 to 40/60; and having a weight average molecular weight of from 50,000 to 500,000; and a hair treating method with the composition.

The hair cosmetic composition of the invention can essentially improve the hair quality, give excellent luster, manageability, setting property to the hair, and also give excellent flexible hair feel and elasticity.

The invention provides a non-naturally occurring microbial organism having a muconate pathway having at least one exogenous nucleic acid encoding a muconate pathway enzyme expressed in a sufficient amount to produce muconate. The muconate pathway including an enzyme selected from the group consisting of a beta-ketothiolase, a beta-ketoadipyl-CoA hydrolase, a beta-ketoadipyl-CoA transferase, a beta-ketoadipyl-CoA ligase, a 2-fumarylacetate reductase, a 2-fumarylacetate dehydrogenase, a trans-3-hydroxy-4-hexendioate dehydratase, a 2-fumarylacetate aminotransferase, a 2-fumarylacetate aminating oxidoreductase, a trans-3-amino-4-hexenoate deaminase, a beta-ketoadipate enol-lactone hydrolase, a muconolactone isomerase, a muconate cycloisomerase, a beta-ketoadipyl-CoA dehydrogenase, a 3-hydroxyadipyl-CoA dehydratase, a 2,3-dehydroadipyl-CoA transferase, a 2,3-dehydroadipyl-CoA hydrolase, a 2,3-dehydroadipyl-CoA ligase, a muconate reductase, a 2-maleylacetate reductase, a 2-maleylacetate dehydrogenase, a cis-3-hydroxy-4-hexendioate dehydratase, a 2-maleylacetate aminoatransferase, a 2-maleylacetate aminating oxidoreductase, a cis-3-amino-4-hexendioate deaminase, and a muconate cis/trans isomerase. Other muconate pathway enzymes also are provided. Additionally provided are methods of producing muconate.

The invention discloses a method for preparing polyester-polyester blocked copolyester, which comprises the following steps: (1) synthesizing an aromatic polyester hard segment to obtain a prepolymer P1 with a number-average molecular weight in the range of 500-10,000g/mol; (2) synthesizing an aliphatic polyester soft segment to obtain a prepolymer P2, wherein the prepolymer P2 can also be obtained by ring-opening polymerization of caprolactone monomer, and the number-average molecular weight of the prepolymer P2 is in the range of 500-10,000g/mol; (3) carrying out polycondensation reaction of the aromatic polyester oligomer and the aliphatic polyester oligomer: mixing the esterified product P1 and the esterified product P2, adding antioxidant, catalyst, passsivator and chain expander, allowing reaction at 220-260 DEG C to obtain a polyester-polyester block polyester elastomer. The catalysts used in the steps (1) and (2) are selected from titanium-containing organic substances. The method disclosed by the invention has the following advantages: (1) because the aliphatic polyester soft segment is introduced, the product has both the mechanical properties of the rigid aromatic polyester hard segment and the flexibility of the soft segment; and (2) because a number of assistants are added, the good chain expansion effect is achieved, and the reaction conditions are controlled.