Patents
Literature
2 results about "Lactone formation" patented technology
Efficacy Topic
Property
Owner
Technical Advancement
Application Domain
Technology Topic
Technology Field Word
Patent Country/Region
Patent Type
Patent Status
Application Year
Inventor
Lactones are formed by intramolecular esterification of the corresponding hydroxycarboxylic acids, which takes place spontaneously when the ring that is formed is five- or six-membered. Lactones with three- or four-membered rings (α-lactones and β-lactones) are very reactive, making their isolation difficult.
Graded preparation of high-purity GG sodium alginate plant-based enteric capsule and method
PendingCN119970682AInorganic non-active ingredientsPharmaceutical delivery mechanismBiotechnologyBiochemistry
The invention discloses a graded preparation method of a high-purity GG sodium alginate plant-based enteric capsule and a method thereof, belongs to the technical field of biology and new medicine, and solves the technical problems that the content of guluronic acid (G) in a preparation method of a sodium alginate plant-based enteric capsule in the prior art is relatively low; the technical problems that the sodium alginate plant-based enteric capsule is poor in mechanical strength, poor in stability and poor in disintegration effect are solved. According to the method for preparing the high-purity GG sodium alginate plant-based enteric capsule in the grading mode, sodium alginate is subjected to dissolution grading treatment to extract a high-purity GG chain segment, calcium salt and glycerin are added for sol and stewing treatment, lactone is added to form part of microgel particles, and then the microgel particles are soaked with glue and pressed into a film to prepare the high-purity GG sodium alginate plant-based enteric capsule. The high-purity GG sodium alginate plant-based enteric capsule has the advantages that the structure is compact, the acid-resistant stability is good, the slow-release effect is excellent, and the production efficiency and the quality of a product are effectively improved.
Owner:青岛海之林生物科技开发有限公司
A method for preparing the active pharmaceutical ingredient butylphthalide
This invention provides an environmentally friendly method for preparing the active pharmaceutical ingredient butylphthalide. Using butylphthalide as a raw material and water as a solvent, the active pharmaceutical ingredient butylphthalide is prepared in a simple, environmentally friendly one-pot process via hydrolysis with sodium hydroxide solution, acidification with sulfuric acid solution, and reductive lactone formation catalyzed by an iridium catalyst. After simple extraction, drying, and concentration, a product with a purity greater than 99% according to 1H NMR spectroscopy and a yield greater than 90% is obtained. The synthetic method provided by this invention features concise reaction conditions and steps, simple operation, is environmentally friendly, has high synthesis efficiency, and facilitates separation and purification. It has promising industrial applications and plays a positive role in organic synthesis, pharmaceutical production, and fine chemicals.
Owner:BEIJING UNIV OF CHEM TECH