29 results about "Ivermectin" patented technology

The utility model relates to the technical field of glass-lined reaction kettles, and discloses a glass-lined reaction kettle for decatalyzing ivermectin, which comprises a reaction kettle, the bottom of the reaction kettle is in coupling connection with an outlet body, the top of the outlet body is fixedly connected with two air cylinders, the driving ends of the air cylinders are fixedly connected with connecting blocks, and the connecting blocks are fixedly connected with the bottom of the reaction kettle. Two clamping blocks are rotatably connected to the front end of the connecting block, a first sliding groove is formed in each clamping block, a supporting shaft is slidably connected to the interior of each clamping block, a plurality of telescopic columns are fixedly connected to the top of the outlet body, springs are arranged on the outer portions of the telescopic columns in a sleeving mode, and a leakage-proof ring is fixedly connected to the tops of the telescopic columns. According to the utility model, the clamping block is pushed to fall off from the reaction kettle, the sliding chute I is bound by the supporting shaft, the clamping block rotates oppositely to be separated, the installation is operated reversely, the plurality of springs are extruded to store elastic force and are connected to release the elastic force, the outlet body is separated, the reaction kettle is convenient to clean, and the sealing performance is ensured during installation.

The invention relates to a combined mouse and insect killing composition, a combined mouse and insect killing bait and a combined mouse and insect killing method for simultaneously inhibiting reproduction of field mice and killing ectoparasites of the field mice. The combined mouse and insect killing composition comprises ivermectin and atrazine, the weight ratio of the ivermectin to the atrazine is (1-9): (9-90). The mouse and insect combined killing bait comprises the mouse and insect combined killing composition and basic bait. The combined mouse and insect killing method comprises the step of applying the combined mouse and insect killing composition or the combined mouse and insect killing bait to wild mice. The mouse and insect combined killing composition and bait can control the population density of mice by inhibiting the reproductive system function of the mice in the field on the premise of not directly killing the mice, and meanwhile effectively kill parasites such as fleas, ticks and the like on the body surfaces of the mice, and block a disease transmission chain. Therefore, the combined mouse and insect killing composition and the bait have the combined control effects of inhibiting reproduction of field mice and killing ectoparasites of the field mice.

The invention belongs to the technical field of veterinary treatment medicines, and relates to a compound ivermectin juglone liniment as well as a preparation method and application thereof. The compound ivermectin juglone liniment is prepared from the following components in percentage by weight: 0.2 percent to 0.7 percent of juglone, 0.3 percent to 0.7 percent of ivermectin, 0.8 percent to 1 percent of tween-80, 0.1 percent to 0.15 percent of butylated hydroxytoluene, 0.2 percent to 5 percent of azone, 0.05 percent to 5 percent of menthol, 1 percent to 12 percent of isopropyl myristate and the balance of medium chain triglyceride, the compound ivermectin juglone liniment can be used for effectively removing parasites of animals, and is non-toxic and low in toxicity.

The invention relates to the technical field of pesticide residue detection, in particular to a method for rapidly screening neonicotinoid and macrolide pesticide residues in vegetables through trichogramma chilonis. The 10% lethal effect condition of the trichogramma on nine kinds of common neonicotinoid or macrolide pesticides such as imidacloprid, acetamiprid, dinotefuran, thiamethoxam, clothianidin, nitenpyram, abamectin, methylamino abamectin benzoate and ivermectin is determined; acute toxic effects and action rules of nine common neonicotinoid or macrolide pesticides in vegetables on trichogramma are researched; according to the method, the 1-hour action dose of the pesticide is determined by adopting 10% of death effect, the detection limit of the trichogramma biotoxicity method on the residues of the 9 pesticides in the vegetables is calculated by combining the quality and surface area of the vegetables, and finally, the common neonicotinoid or macrolide pesticide residues in the vegetables are rapidly screened by adopting the trichogramma biotoxicity limit value determination method.

The application provides a compound agent for preventing and treating termites based on Serratia marcescens, which comprises 7.75x10 8 ~2.63x10 12 CFU / mL of Serratia marcescens, and a pathogenic fungus or a biological pesticide or an insect growth regulator or a chemical agent; the pathogenic fungus is Beauvaria bassiana or Metarhizium anisopliae; the biological pesticide is ivermectin; the insect growth regulator is lufenuron or buprofezin or diflubenzuron; and the chemical agent is emamectin benzoate or indoxacarb. The compound agent has obvious synergistic effect on preventing and treating termites, reduces the use amount of single agent, is lower in cost, more efficient, stable and green.

A topical formulation, comprising: an ointment base; and a mixture of active pharmaceutical ingredients (APIs) contained in the ointment base, the mixture of APIs consisting of: Metronidazole; Ivermectin; and Melaleuca alternifolia (tea tree) oil. The APIs are about 0.12%-6% w / w and the ointment base is about 94% to 99% w / w of the topical formulation. The formulation can further include enhancers for the APIs, such as, moisturizers and anti-oxidants. The formulation is configured as an anti-parasitic, anti-inflammatory and anti-microbial formulation.

A medicated eyelid cleansing composition comprising a medicated scrub composition and an eyelid cleansing composition. The medicated scrub composition has one or more antibacterial and anti-inflammatory agents, including azithromycin and diclofenac sodium or dexamethasone phosphate. The medicated scrub composition can further include a combination of metronidazole and ivermectin. The composition is optimized for physiological compatibility and can be combined with a suitable substrate for use as a medicated eyelid cleanser.

The invention discloses a transmembrane protein 16F and application of a gene coded by the transmembrane protein 16F as a target spot in preparation of a medicine for regulating and controlling tumor ferroptosis. The tumor is any one of lymphoma, melanoma, colon cancer, cervical cancer, fibrosarcoma and ovarian epithelial cancer. The invention finds that TMEM16F is a ferroptosis inhibiting factor which does not change a cell lipid peroxidation process, and shows that the spatial distribution of oxPLs can regulate ferroptosis. In the ferroptosis process, the TMEM16F-mediated phospholipid overturning process is activated, and the effect of regulating and controlling phospholipid redistribution is achieved. In addition, the combination of TMEM16F defect and anti-PD-1 treatment shows a synergistic anti-tumor effect, and initiates a strong tumor immunological rejection reaction. The ivermectin has the biological activity of inhibiting the overturning function of TMEM16F phospholipid, and the inhibition effect of the ivermectin on TMEM16F effectively enhances the reactivity of anti-PD-1 treatment.

The invention discloses a preparation process of ivermectin for vacuum freeze-drying injection, which comprises the following steps: S1, mixing ivermectin, polyethylene glycol and water for injection to obtain a mixed solution A; s2, the mixed solution A and modified activated carbon are stirred and subjected to decarburization treatment, filtrate is obtained, and the modified activated carbon is prepared by modifying activated carbon through alanine and succinic anhydride in sequence; and S3, freeze-drying the filtrate to obtain the ivermectin for vacuum freeze-drying injection. The modified activated carbon is added in the preparation process and reacts with the ivermectin to form the salt, so that the redissolution speed and solubility of the ivermectin in subsequent water can be improved, and the used modified activated carbon can effectively filter and reduce the impurity content in the finished ivermectin, so that the quality of the ivermectin is improved. Compared with the conventional ivermectin injection produced by taking propylene glycol, glycerol formal and the like as solvents, the ivermectin injection prepared by the invention has the advantages of good solubility in water, high absorption speed, higher absorption completeness, large apparent distribution volume and high bioavailability.

The invention provides a pesticide composition containing antibiotic compounds, the pesticide composition is composed of a first effective component and a second effective component, the first effective component is a compound with a structural formula (I), the second effective component is methylamino abamectin benzoate, abamectin, spinosad, spinetoram or ivermectin, and the weight ratio of the first effective component to the second effective component is (1-50): (1-50). The invention also provides application of the pesticide composition in prevention of agricultural and forestry pests. The invention verifies that the binary composition obtained by compounding the flufenutraniliprole and the antibiotic insecticide in a proper proportion has a remarkable synergistic effect, so that the effects of improving the control effect, reducing the dosage and expanding the insecticidal spectrum are achieved. The composition disclosed by the invention has an excellent control effect on target pests such as chilo suppressalis, plutella xylostella, green peach aphid, beet armyworm, ostrinia nubilalis, thrips and flea beetle. (I).

The utility model discloses a mixer for mixing albendazole ivermectin premix, which comprises a machine body, a hopper and a valve device, the hopper is arranged at the lower end of the machine body, fixedly connected with the machine body and communicated with the machine body, and the valve device is arranged at the upper end of the hopper and fixedly connected with the hopper. The machine body, the hopper, the valve device, the auxiliary device, the slapping assembly, the rotating seat, the slapping plate, the tension spring, the linkage assembly, the supporting seat, the rotating rod, the extrusion wheel, the control assembly, the supporting plate, the motor, the first belt wheel, the second belt wheel and the rubber block are used in cooperation. The problems that in the prior art, a part of premixing agent is left and attached to the inner wall of the hopper and cannot be well treated, so that discharging of the hopper is not thorough, and the part of premixing agent is wasted are solved.

The invention discloses a novel process for preparing a liquid fertilizer from ivermectin waste liquid, and relates to the technical field of fertilizer preparation, aniline and acetic acid are used as raw materials, sulfuric acid catalytic esterification and nucleophilic substitution reaction with mercaptoethanol are performed to prepare a complexing agent, the complexing agent is added into the pretreated waste liquid, a reaction is performed to obtain a liquid fertilizer semi-finished product, and the liquid fertilizer semi-finished product is obtained. The preparation method comprises the following steps: mixing polyoxyethylene sorbitan fatty acid ester and sodium dodecyl benzene sulfonate, adding a buffer agent, stirring to prepare a compatibility regulator, adding the liquid fertilizer semi-finished product, and homogenizing to obtain the quasi-liquid fertilizer. According to the present invention, the liquid fertilizer is subjected to esterification reaction under the catalysis of sulfuric acid to construct the basic structure skeleton of the complexing agent so as to form the intermediate with the partial coordination ability, and the treated liquid fertilizer has characteristics of stable physicochemical property and strong compatibility after being mixed and stored with a variety of fertilizers and pesticides, such that the comprehensive application benefit in the agricultural production is substantially improved.

The present application relates to a kind of suspension formulation of ivermectin and preparation method thereof, including effective component 1.5%~40%, synergistic adjuvant composition 2%~10%, other adjuvant 0.1%~45%, with water to 100%.Wherein, the effective component is ivermectin and component M, component M is chlorfenapyr or spirotetramat, and the mass ratio is 1:1~1:20;The synergistic adjuvant composition is isomeric alcohol polyoxyethylene ether and fatty amine polyoxyethylene ether, and the mass ratio of the two is 1:10~7.5:1.Compared with prior art, the present application can alleviate the problem of reduced heat storage suspension rate caused by adding isomeric alcohol polyoxyethylene ether to ivermectin suspension formulation, improve the control effect on phytophagous mites and lepidoptera pests, and meet the practical needs of processing, storage, safety and field application.

The application relates to the technical field of fine chemical production, and particularly discloses a crystallization process of short-rod-shaped ivermectin, which comprises the following steps: dissolving ivermectin crude product in a crystallization solvent, heating to 50-55 DEG C, adding a crystallization agent, uniformly mixing, then cooling to 35-40 DEG C at a rate of 0.1-0.3 DEG C / min, adding ivermectin crystal seeds, continuously cooling to 5-15 DEG C, and incubating and crystallizing to obtain ivermectin products. The crystallization process of ivermectin provided by the application realizes effective control of the particle size and crystal habit of ivermectin products in the crystallization process by adopting a combination strategy of selecting a specific crystallization solvent, adding a crystallization agent and crystal seeds at specific stages, controlling the cooling rate and the incubation time, obtaining short-rod-shaped ivermectin products with uniform particle size distribution, and the products have good fluidity, are convenient for subsequent preparation application, do not need repeated crystallization for multiple times, effectively reduce the cost of the crystallization process, and have extremely high practical application value.

In alternative embodiments, provided are methods for treating, ameliorating, decreasing the chances of having any adverse effects from, decreasing the severity of adverse effects from, or preventing an infection, or boosting or enhancing natural immunity acquired by an infected individual, by administration of: an inactivated infectious causative agent of the infection, or an antibiotic and / or an anti-viral drugs and a vaccine directed to a causative agent of the infection and / or an attenuated and / or a live, viable or infectious causative agent of the infection. In alternative embodiments, the infection is bacterial or viral. In alternative embodiments, the viral infection is a coronavirus infection such a Covid-19 infection. In alternative embodiments, methods as provide herein prevent or decrease the prevalence or severity of “vaccine breakthrough infections” after vaccination, where external mutants of COVID-19 infect patients in spite of the fact that they have undergone immunization, for example, to prevent a mutant or variant COVID-19 infection. In alternative embodiments, an antiviral combination administered in coordination with a vaccine comprises PF-07321332 or PAXLOVID™ and / or ritonavir, or ivermectin, doxycycline and a zinc or a zinc salt. In alternative embodiments, methods as provided herein are used to prevent in vivo mutations of such mutant infectious agent to enhance the efficacy of an administered vaccination; in other words, methods as provided herein are used to prevent in vivo replication of an acquired viral mutant or variant infectious agent, and thus also prevents ongoing mutations of the viral infectious agent because using the combination antiviral co-therapy where there is no replication of infectious agent and so there is no possible further mutation of the infectious agent.

This invention relates to the field of veterinary drug technology, and proposes a compound composition for the prevention and treatment of shrimp hepatocellular carcinoma and its preparation method. The compound composition comprises the following raw materials: albendazole, ivermectin, and glycyrrhizic acid monoammonium salt. The components in the compound composition for the prevention and treatment of shrimp hepatocellular carcinoma provided by this invention work synergistically to safely control the disease and ensure the healthy and sustainable development of aquaculture.

Laboratory apparatus for evaluation and modulation of ivermectin drug–induced neurotoxicity using therapeutic intervention agents

The invention belongs to the technical field of nematode prevention and control pesticides, and relates to a trifluoropyridinamine compound pesticide composition for preventing and controlling nematodes. The effective component of the pesticide composition is prepared by compounding the trifluoropyridylamine with the emamectin benzoate, the ivermectin, the abamectin B1 or the abamectin B2 respectively. The components are compounded in the range provided by the invention, a synergistic effect can be generated, and the comprehensive prevention and treatment effect after the components are compounded pairwise is obviously higher than that of single use of the two components. The effect of improving the plant growth quality is obvious, and the yield of crops applying the composition is obviously increased. Besides, the action mechanisms of the trifluoropyridinamine and the four substances are different, so that the generation of drug resistance can be delayed, the lasting period is long, and the drug use frequency can be reduced.

The present invention provides compositions comprising extracts from specific plant genera or alternatives thereof, including Lithospermum and Oryza or alternatives thereof, along with optional extracts from Scutellaria and Boswellia. The compositions thus include shikonin, anthocyanins, and other bioactive compounds such as flavonoids and boswellic acids. Additional ingredients like ivermectin, metformin, and curcumin may be incorporated. The compositions are designed as multi-targeted therapeutic agents, combining viral protease inhibitors, endogenous host protease inhibitors, anti-inflammatory agents, and anti-senescence agents. These compositions are intended for treating various medical conditions, including respiratory diseases, viral infections, inflammatory conditions, immune-related disorders, liver conditions, and neurological conditions. The invention describes methods of treatment and use in manufacturing medicaments for these conditions.

The invention relates to the technical field of veterinary preparations. The invention provides a special anti-parasitic chewable tablet for animals and a preparation method thereof. The chewable tablet is prepared from the following components in parts by weight: 10.5 to 16 parts of active ingredients, 11.5 to 18.5 parts of glycerol, 15 to 20 parts of gelatin, 8 to 10 parts of maltitol or sorbitol, 6 to 9 parts of microcrystalline cellulose, 10 to 20 parts of adhesive, 0.5 to 1.5 parts of magnesium stearate, 0.1 to 0.5 part of vitamin E and 0.01 to 0.05 part of BHT (butylated hydroxytoluene) or BHA (butylated hydroxytoluene), the active component is one or more of arfamarin, fluralab, selamectin and ivermectin. The invention further relates to a preparation method of the pesticide composition containing the fluralab, the selamectin and the ivermectin. The chewable tablet disclosed by the invention is suitable for efficiently preventing and treating ticks, mites and fleas by animals, and has the characteristics of good palatability and convenience in administration. The blank of combination of a flexible dosage form and efficient parasite expelling in the prior art is filled up, and the composition is suitable for animal feeding and particularly suitable for daily prevention and treatment of companion animals.

The invention relates to an ivermectin and etoxazole compound suspending agent which comprises the following components in percentage by weight: 1-60% of effective components, 2-25% of synergistic additive composition, 0.1-10% of other additives and the balance of water. Wherein the effective components are ivermectin and etoxazole, the mass ratio of the ivermectin to the etoxazole is (1: 1)-(1: 30), the synergistic aid is a combination of iso-tridecanol polyoxyethylene ether and styrene-acrylate emulsion, and the mass ratio of the iso-tridecanol polyoxyethylene ether to the styrene-acrylate emulsion is (1: 10)-(10: 1). The two synergistic aids are combined for use, so that the pesticide effect performance of the ivermectin and etoxazole compound suspending agent can be improved, a synergistic interaction effect is achieved, and the prevention effect is superior to that of single use of the ivermectin and etoxazole compound suspending agent.

The invention discloses an acaricidal composition and application thereof, the composition takes ivermectin and amitraz as main effective components, the weight part ratio of the ivermectin to the amitraz is 5: 1-1: 60, and the weight percentage of the active components in the acaricidal composition is 3%-70%. The composition disclosed by the invention has relatively high activity on tetranychid, and particularly has a remarkable synergistic interaction performance on tetranychus urticae (Koch), panonychus citri (McGreen), panonychus ulmi (Koch) and tetranychus vienis (Zacher), so that the composition disclosed by the invention can be used for preventing and controlling the tetranychus urticae (Koch), the panonychus ulmi (Koch) and the tetranychus vienis (Zacher), and can be used for preventing and controlling the tetranychus urticae (Koch) and the tetranychus vienis (Zacher).

The invention discloses genetically engineered streptomyces as well as a construction method and application thereof. According to the present invention, with the application of the CRISPR-Cas9 gene editing technology, the aveA3 fragment in the Streptomyces avermitilis gene cluster capable of generating the ivermectin B1b compound is replaced with the milA3 fragment in the Streptomyces hygroscopicus gene cluster so as to obtain the gene engineering Streptomyces, such as Streptomyces avermitilis HU501-M, and the gene engineering Streptomyces HU501-M can be used to produce the ivermectin B1b compound, the constructed genetically engineered streptomyces can be used for preparing milbemycin D, and the compound has efficient insecticidal, acaricidal and antiparasitic activity, is high in safety to human beings and animals, and is environment-friendly. The main fermentation product of the genetically engineered streptomyces is milbemycins D, and the genetically engineered streptomyces has a good industrial development prospect.

The application belongs to the field of anti-parasitic drugs, especially a silica aerogel loaded ivermectin drug-loaded particle processing production line. The existing problems of the need to transport the prepared drug-loaded solid, complicated operation, the need for multiple power devices to stir, mix, high cost, incomplete discharge and complicated operation are solved. The scheme comprises a first mixing box and a collecting box, the outer wall of the first mixing box is fixedly connected with three support rods, the collecting box is located directly below the first mixing box, and the top of the first mixing box is fixedly communicated with a hollow circular table cylinder. In the application, the stirring assembly can fully stir the material, the first mixing box and the second mixing box utilize the power of one servo motor, the cost is greatly reduced, the first support block and the second support block can be lifted by the lifting assembly, the feeding and discharging process is completed, and the loading and unloading are not needed, so the work load is greatly reduced.

The application belongs to the technical field of antibiotic application, and discloses that microplastics affect the absorption of ciprofloxacin in the intestinal tract through the TLR4 / NF-kappa B pathway regulating P-gp protein. Our research finds that microplastics can activate the expression of P-gp glycoprotein in intestinal epithelial cells through the NF-kappa B pathway in the intestinal tract, thereby reducing the absorption of ciprofloxacin hydrochloride in the intestinal tract, and further affecting the core mechanism of pharmacokinetics and pharmacodynamics of ciprofloxacin hydrochloride in animals. Pyruvate ethyl effectively inhibits the NF-kappa B pathway. The application also finds that after ivermectin inhibits the P-gp glycoprotein of Caco2 cells, the P-gp glycoprotein cannot efflux ciprofloxacin hydrochloride, so that the content of ciprofloxacin hydrochloride in Caco2 cells increases. Therefore, the application also protects the application of ivermectin in preparing a promoter of the content of ciprofloxacin hydrochloride in Caco2 cells incubated with microplastics.

A medicated eyelid cleansing composition comprising a medicated scrub composition and an eyelid cleansing composition. The medicated scrub composition has one or more antibacterial and anti-inflammatory agents, including azithromycin and diclofenac sodium or dexamethasone phosphate. The medicated scrub composition can further include a combination of metronidazole and ivermectin. The composition is optimized for physiological compatibility and can be combined with a suitable substrate for use as a medicated eyelid cleanser.

The invention belongs to the field of chemical synthesis, and particularly relates to a tetrahydrothiophene sulfone derivative, a preparation method thereof and application of the tetrahydrothiophene sulfone derivative in preparation of acaricidal drugs. The chemical structural formula of the tetrahydrothiophene sulfone derivative is as shown in formula I, and R is fluorine, chlorine, bromine or trifluoromethyl. The preparation method comprises the following steps: mixing and stirring elemental sulfur and an alkaline raw material, sequentially adding substituted benzaldehyde and acetophenone, reacting to obtain an intermediate, and finally oxidizing, distilling, cleaning and recrystallizing to obtain the sulfur-containing compound. Experiments prove that the acaricidal activity of the tetrahydrothiophene sulfone derivative is obviously superior to that of ivermectin, and the median lethal concentration and time are lower. The compound is simple in preparation process, mild in condition and high in yield, has important application value in the aspect of preparing acaricides, provides a new choice for preventing and treating animal acariasis, and is beneficial to reducing the loss of the breeding industry.

Methods for producing nanoparticles of hydrophobic compounds, such as EGCG-palmitate, Cannabidiol (CBD), Delta-9-tetrahydrocannabinol (THC-9), quercetin, ivermectin, retinoic acid, curcumin, resveratrol, lycopene, lutein, CoQ10, procyanidin B2, oxyresveratrol, tetrahydropiperine, rapamycin, forskolin, and tetrahydrocurcumin, are described. In some forms, one or more water soluble compounds are used with at least one hydrophobic compound to form the nanoparticles. Nanoparticles produced using the disclosed methods have tightly packed structures assembled by the hydrophobic compounds themselves, without the need for other components, such as surfactant, polymer, encapsulation, or metals. These nanoparticles can significantly increase the water solubility of hydrophobic compounds, allowing increased solubility and bioavailability in their own nanoparticle form.