183 results about "Reproductive system" patented technology

The invention relates to the field of preparation and application of biological peptides, in particular to a hippocampal swelling peptide and application thereof in preparation of functional products for repairing male reproductive system injury. A green controllable enzymolysis technology is utilized to obtain protein polypeptide with nutritional, health-care and medicinal values, five active peptide sequences with high biological activity are obtained through further research on the basis, the high-purity active peptide is obtained through a chemical synthesis mode, and the biological activity of the peptide is verified through mouse spermatogonium.

The invention discloses a multiple primer group for detecting pathogens of reproductive system diseases and a kit thereof. The kit comprises a combination of amplification primers and fluorescent probes of 10 pathogens, the pathogens comprise molluscum contagiosum virus, Snethia bacteria, gardnerella vaginalis, prevotella genus, campylobacter genus, giant globules genus, Atortobacter vaginalis, lactobacillus jensenii, lactobacillus crispatus and inert lactobacillus. The kit contains UDG enzyme and is used for preventing pollution of a PCR amplification product, and the accuracy of a detection result is ensured. The kit provided by the invention contains an internal reference control, can display the occurrence of false negative, and is used for monitoring the collection, transportation, extraction and amplification processes of a to-be-detected sample. According to the kit, the specificity is 100%, the detection sensitivity reaches 10 copies / mL, the specificity is good, and the detection efficiency is high. The kit is used for identifying the reproductive system disease pathogens of a to-be-detected sample, the to-be-detected sample can be vaginal secretion, the operation steps are simple, and the detection period is short.

The invention provides a kit and a method for simultaneously detecting 11 pathogens of a urogenital system and application, and belongs to the field of molecular biology. The primer group is used for detecting urogenital tract pathogens, and the urogenital tract pathogens comprise ureaplasma urealyticum (UU), chlamydia trachomatis (CT), mycoplasma genitalium (MG), ureaplasma parvum (UP), mycoplasma hominis (MH), adenovirus (ADV), trichomonas vaginalis (TV), herpes simplex virus type I (HSV-I), herpes simplex virus type II (HSV-II), haemophilus influenzae (HI) and neisseria gonorrhoeae (NG). The primer group is used for multi-joint detection of non-gonococcal urethritis related pathogens, has high specificity and sensitivity, is adaptive to non-invasive urine specimens, and supports home self-sampling. The kit is used for clinical diagnosis and can quickly judge pathogen types. Precise medication is performed based on a detection result, the healing time of a patient is shortened, the burden of a doctor is relieved, and meanwhile the pathogen transmission risk is reduced.

The invention provides a tightening and repairing gynecological gel. Preparation raw materials comprise carbomer, sodium hyaluronate, an animal umbilical cord extract, madecassoside, carnosine, a polygonum cuspidatum root extract, a scutellaria baicalensis root extract, a tea leaf extract, a chamomile flower extract, elastic collagen, arginine, pentanediol, butanediol, glycerin, p-hydroxyacetophenone, capryloyl hydroximic acid and purified water. The gynecological gel can maintain balanced strains, so that the microenvironment of the vagina is kept normal; vaginal atrophy is improved, the tight state of the vagina is recovered, and vaginal dryness is relieved; damaged mucosa can be repaired, the natural defense function of women is enhanced, and gynecological infection is prevented. The gynecological gel has good biocompatibility, cell affinity and mechanical properties, and can supplement collagen to female private parts, repair damaged vaginal mucosa and promote wound healing; the vagina can be moisturized and moistened, the looseness and dryness of the vagina are improved, the micro-ecological balance of the vagina is adjusted, and the immunity of a female reproductive system is improved.

The invention relates to the technical field of biomedical treatment, in particular to bifidobacterium longum subsp. Longum and application thereof in drugs related to reproductive system diseases. The invention provides a strain of Bifidobacterium longum subsp. Longum NCU-06, which is preserved in China General Microbiological Culture Collection Center (CGMCC), the preservation address is No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing, the preservation date is January 18, 2023, and the preservation number is CGMCC No.26491. The invention also provides a method for preparing the Bifidobacterium longum subsp. Longum NCU-06. The bifidobacterium longum subsp. Longum NCU-06 has a treatment effect on various female reproductive system diseases, for example, the bifidobacterium longum subsp. Longum NCU-06 can be used for treating endometriosis, ovarian cancer, ovarian cancer parneoplastic thrombocythemia and ovarian hyperstimulation syndrome.

The invention provides an ovary-targeting ROS response type SS31 nano-particle and a preparation method and application thereof, and belongs to the field of biomedicine.The ovary-targeting ROS response type SS31 nano-particle is constructed by utilizing a porous metal organic framework to carry hyaluronic acid and utilizing an ROS response type thioketone linker to be combined with mitochondrial targeting peptide SS31, and the ovary-targeting ROS response type SS31 nano-particle is used for preparing the ovary-targeting ROS response type SS31 nano-particle. And the SS31 is targeted and delivered to the ovarian tissue. The nanoparticles target ovary and slowly release SS31 under the action of ROS, so that oxidative stress of oocytes and granular cells caused by female reproductive system diseases such as premature ovarian failure, polycystic ovarian syndrome and the like is reduced, and the mitochondrial function of the oocytes and the granular cells is improved; and a foundation is laid for the subsequent clinical treatment of diseases related to the mitochondrial dysfunction of the female reproductive system by using the SS31.

The invention provides a teaching interaction processing method and system applied to an intelligent online practical training platform. The method comprises the following steps: firstly, acquiring a training scene data set comprising operation process simulation data (corresponding to gynecological examination and related medical skill standard operation processes) and anatomical structure model data (constructed based on medical image data and comprising three-dimensional structure feature information of a female reproductive system), and then carrying out interactive content generation processing on the training scene data set; generating interactive teaching content including operation step guide information and a three-dimensional dissection display model by combining teaching logic rules, and then receiving interactive operation data (corresponding operation simulation behaviors including operation action time sequence records and spatial position coordinates) of a user on a platform; then training effect evaluation processing is carried out on the interactive operation data and the interactive teaching content to generate a training evaluation result, and finally personalized feedback content is generated according to the evaluation result and pushed to a user interface to guide a user to adjust a training behavior, so that the medical training teaching quality and efficiency are improved.

A medical device for performing a surgical procedure may include an elongate member having a proximal end, a distal end, and a lumen extending therebetween. The medical device may also include a handle connected to the proximal end of the elongate member, an end effector assembly connected to the distal end of the elongate member, and a cutting device configured to extend from the end effector assembly, wherein the cutting device has a retracted configuration in which the cutting device is withdrawn into the end effector assembly and a deployed configuration in which the cutting device extends from the end effector assembly.

The present invention belongs to the field of traditional Chinese medicines, and particularly relates to Leixihaokang, a preparation method therefor, and use thereof. The Leixihaokang of the present invention is prepared from the following active pharmaceutical ingredients in parts by weight: 10 parts of Tripterygium glycosides and 0.1-1.3 parts of Artemisia annua extract. According to the present invention, animal experiments prove that the Leixihaokang can ameliorate renal damage in nephrotic syndrome caused by adriamycin, reduce the occurrence of proteinuria, and reduce the apoptosis of renal tissue cells. Meanwhile, the Leixihaokang of the present invention has a good inhibitory effect on renal, hepatic, splenic, and cardiac toxicity in the treatment process of nephrotic syndrome. According to the present invention, animal experiments also prove that the Leixihaokang can ameliorate skin injury in imiquimod-induced psoriasis, reduce inflammatory infiltration and alleviate skin damage. Meanwhile, the Leixihaokang has a certain degree of inhibitory effect on the hepatic and reproductive system toxicity in the treatment process of psoriasis.

The invention discloses application of trans-anisd in relieving toxicity of zearalenone in animals, and belongs to the technical field of prevention and treatment of mycotoxin. The invention provides an application of trans-anisd in preparation of a medicine or feed for relieving zearalenone poisoning of animals. The trans-anisd is proved to be capable of effectively relieving piglet reproductive toxicity caused by zearalenone, improving uterine organ indexes and ovarian organ indexes and ensuring piglet health and reproductive system development, and a new method is provided for zearalenone detoxification.

The invention discloses an experimental device and method for simulating rat reproduction influence under exposure of a low-pressure anoxic environment, relates to the technical field of reproduction influence experiments, and provides the following scheme that the experimental device comprises a low-pressure experimental module fixed on the ground and a vacuum pump erected on the top surface of the low-pressure experimental module, the extraction end of the vacuum pump penetrates into an inner cavity of the low-pressure experiment module through a pipeline, a hatch is formed in the left side of the low-pressure experiment module, and a hatch door is installed on the end face of the hatch through a hinge. According to the technical scheme, by simulating the day and night temperature difference at the altitude of 4000 m and 6000 m and 12 DEG C / 2 DEG C in the low-pressure experiment module and simulating the plateau environment to feed rats, the plateau low-oxygen exposure environment can be closer to the plateau low-oxygen exposure environment, and by conducting slice detection on testicular tissue of the test rats, damage data of the low-pressure low-oxygen exposure environment to the male reproductive system is obtained. Therefore, the method has certain good reproducibility on reproductive system injury in a low-pressure and low-oxygen exposure environment.

The curcumin disclosed by the invention has the medicinal activity of preventing and treating mouse spermatogonial cell GC1 injury caused by triptolide, so that the curcumin has potential application value in the aspect of preparing medicines for preventing and treating spermatogonial cell injury caused by a tripterygium wilfordii preparation. Experimental results show that curcumin can be used for protecting spermatogonial cell damage caused by triptolide by regulating oxidative stress and reducing cell apoptosis. Therefore, a new thought and approach can be provided for clinical application of traditional Chinese medicine in male reproductive system injury repair. Furthermore, a new thought and a new approach are provided for clinical adjuvant medication of the triptolide, namely, the tripterygium wilfordii preparation containing the triptolide and the curcumin is developed, so that the anti-cancer drug activity and the like of the triptolide can be exerted, the reproductive injury side effect of the triptolide is inhibited or relieved through the curcumin, and the application prospect is wide. Spermatogonial cell injury induced by triptolide is effectively recovered, and particularly, spermatogonial cell oxidative stress injury and apoptosis caused by triptolide are effectively protected.

The invention aims to provide a preparation method of amnion-derived mesenchymal stem cells with high collagen expression. The preparation method comprises the following steps: step 1, reagents and materials: amnion tissues: obtaining a fresh amnion from a healthy puerpera after delivery; the PBS is used for cleaning amniotic tissues; collagenase: type I collagenase, which is used for digesting amniotic tissues to separate mesenchymal stem cells; a cell culture medium is a DMEM / F12 culture medium, and 10% of fetal calf serum and 1% of penicillin-streptomycin double antibodies are added; the transforming growth factor TGF-beta is used for promoting the expression of mesenchymal stem cell collagen; and the fibroblast growth factor FGF can assist in promoting cell proliferation and collagen expression. The invention aims to provide the preparation method of the amniotic membrane-derived mesenchymal stem cells for highly expressing collagen, and the amniotic membrane-derived mesenchymal stem cells can be widely applied to treatment of immune system diseases, reproductive system diseases, skin system diseases, skeletal system diseases, nervous system diseases, digestive system diseases, respiratory system diseases, circulatory system diseases and urinary system diseases. Particularly, the effects of immunosuppression and tissue repair are achieved.

The invention provides a reproduction-promoting replacement gilt compound feed as well as a preparation method and application thereof. The reproduction-promoting replacement gilt compound feed comprises the following components in parts by weight: 80-110 parts of a base material, 1-2 parts of calcium salt, 1-3 parts of a functional additive and 1-2 parts of a premix, the functional additive is prepared from the following components in parts by weight: 10 to 30 parts of plant extract, 0.01 to 0.1 part of punicalagin and 0.01 to 0.1 part of asperuloside. The replacement gilt compound feed provided by the invention can stimulate the reproductive system of a replacement gilt to rapidly mature, remove excessive free radicals generated by the body, maintain the balance of an oxidation-reduction system in the body, avoid oxidative stress damage to the reproductive system of the replacement gilt, start the puberty period of the replacement gilt in time, promote the replacement gilt to oestrus, and improve the survival rate of the replacement gilt. The reproductive capacity of the replacement gilts is improved.

The invention belongs to the field of kidney tonifying and essence securing traditional Chinese medicine, and discloses kidney tonifying and essence securing traditional Chinese medicine pills and a preparation method thereof.The kidney tonifying and essence securing traditional Chinese medicine pills are prepared from, by mass, 15 parts of herba cistanche, 12 parts of radix morindae officinalis, 20 parts of radix rehmanniae praeparata, 15 parts of semen cuscutae, 12 parts of flatstem milkvetch seeds, 10 parts of fructus corni, 10 parts of fructus rosae laevigatae, 10 parts of fructus rubi, 12 parts of mulberries, 15 parts of rhizoma dioscoreae, 10 parts of poria cocos, 6 parts of fructus schizandrae and 6 parts of honey-fried licorice roots. The prescription has the effects of tonifying yin and yang, consolidating diarrhea and harmonizing spleen and kidney; the traditional Chinese medicine has the effects of tonifying kidney and replenishing essence, securing essence, regulating metabolism and delaying senescence of a reproductive system.

The present invention relates to an oral extract composition comprising Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) extract composition, and its process of preparation. Also relates to the oral extract composition formulation comprising with synergistic combinations of the Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) in suitable doses and at least one nutraceutically and / or pharmaceutically accepted excipient for, improvement, and maintenance of women health more preferably in improving of hot flashes, night sweats, poor sleep, anxiety, sexual dysfunction, mood changes, Genitourinary symptoms in overall improving the quality of life, serum estradiol, progesterone, follicle stimulating hormone (FSH), and cortisol during the period of menopause (perimenopause and menopause). The oral extract composition formulation comprising with synergistic combinations of the Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) in suitable doses and at least one nutraceutically and / or pharmaceutically accepted excipient is used for improving Brain-derived neurotrophic factor (BDNF) levels in women during the period of menopause. The present invention, further related to the extraction process of Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.), also provides the process for the preparation of formulation composition. This invention further relates to the extraction process from Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) either as individual herbs or co-extraction of the two herbs or mixing the extracts at various stages of the individual extracts.

The present invention provides a probiotic active antibacterial tablet for preventing and treating female reproductive system infection and a preparation method thereof. The present invention is a probiotic active antibacterial tablet for preventing and treating female reproductive system infection, comprising the following raw materials in parts by weight: 1.8-2.5 parts of Lactobacillus reuteri, 1.0-1.2 parts of Lactobacillus rhamnosus, 1.2-1.7 parts of Lactobacillus crispatus, 0.5-0.8 parts of Lactobacillus gasseri, 1.0-1.5 parts of stachyose, 0.8-1.2 parts of inulin, and 2.5-3 parts of plant extract, wherein the plant extract is prepared from the following raw materials: Bletilla striata, Chinese tallow tree leaf, Gentiana scabra, and grapefruit seed. The probiotic active antibacterial tablet prepared by the present invention has a significant inhibitory effect on IGFBP7 protein, can effectively prevent and treat female reproductive system infection, and has good tolerance and safety.

The invention provides a kidney-tonifying direct drinking powder based on eucommia male flower L-arginine and a production process thereof, and relates to the field of solid beverages. The eucommia ulmoides male flower and L-arginine kidney-tonifying direct drinking powder is prepared from the following raw materials in parts by weight: 0.01 to 0.015 part of erythritol, 0.01 to 0.015 part of resistant dextrin, 0.1 to 0.4 part of rhizoma polygonati powder, 0.1 to 0.4 part of rape pollen, 0.1 to 0.2 part of maca powder, 0.05 to 0.16 part of oyster polypeptide, 0.05 to 0.16 part of cordyceps militaris, 1 to 4 parts of eucommia ulmoides male flowers, 0.1 to 0.02 part of raspberries, 0.01 to 0.015 part of folic acid, 0.01 to 0.012 part of taurine, 0.01 to 0.012 part of L-arginine, 0.001 to 0.003 part of L-lysine and 10 to 15 parts of purified water. Through the combination of various raw materials, the beverage has a very good health-care effect on males, enhances the functions of the reproductive system, improves the sperm quality, regulates internal secretion and provides necessary nutrients, and is beneficial to improving the health and pregnancy preparation effect of the males when acting on the bodies of the males together.

The current invention is in the field of molecular biology / pharmacology and provides novel 3-oxabicyclo[3.3.1]nonene compounds and derivatives that modulate the effects of the classical estrogen receptors alpha and beta (ERalpha and ERbeta) with little to no biological or physiological effects on the G protein-coupled estrogen receptor GPER (also known as GPR30). These compounds may function as agonists and / or antagonists of one or more of the disclosed classical estrogen receptors. Diseases that are mediated through one or more of these receptors include cancer (including but not limited to breast (particularly endocrine or anti-hormone resistant, and for the prevention / reduction of endocrine or anti-hormone resistance), reproductive and other hormone-dependent cancers, leukemia, colon cancer, prostate cancer), reproductive (genito-urological) including endometritis, prostatitis, polycystic ovarian syndrome, bladder control, hormone-related disorders, hearing disorders, cardiovascular conditions including hot flashes and profuse sweating, hypertension, stroke, obesity, osteoporosis, hematologic diseases, vascular diseases or conditions such as venous thrombosis, atherosclerosis, among numerous others and disorders of the central and peripheral nervous system, including depression, insomnia, anxiety, multiple sclerosis, neuropathy, neurodegenerative disorders (such as Parkinson's disease and Alzheimer's disease), as well as inflammatory bowel disease, Crohn's disease, coeliac (celiac) disease and related disorders of the intestine, among numerous others as described herein. A contraceptive indication to prevent or reduce the likelihood of pregnancy after intercourse is a further aspect of the present invention.

The invention relates to a combined mouse and insect killing composition, a combined mouse and insect killing bait and a combined mouse and insect killing method for simultaneously inhibiting reproduction of field mice and killing ectoparasites of the field mice. The combined mouse and insect killing composition comprises ivermectin and atrazine, the weight ratio of the ivermectin to the atrazine is (1-9): (9-90). The mouse and insect combined killing bait comprises the mouse and insect combined killing composition and basic bait. The combined mouse and insect killing method comprises the step of applying the combined mouse and insect killing composition or the combined mouse and insect killing bait to wild mice. The mouse and insect combined killing composition and bait can control the population density of mice by inhibiting the reproductive system function of the mice in the field on the premise of not directly killing the mice, and meanwhile effectively kill parasites such as fleas, ticks and the like on the body surfaces of the mice, and block a disease transmission chain. Therefore, the combined mouse and insect killing composition and the bait have the combined control effects of inhibiting reproduction of field mice and killing ectoparasites of the field mice.

The invention belongs to the technical field of medicines, and discloses uridine-5 '-monophosphate and application of a compound of uridine-5'-monophosphate in preparation of a medicine for enhancing the proliferation capacity of male germ cells. It is found for the first time that uridine-5 '-monophosphate has multiplication capacity on male germ cells, when the concentration of uridine-5'-monophosphate is 10 [mu] M, the multiplication effect is optimal, and compared with a control group, the multiplication effect on mouse TM3 cells is increased by 52.87%, and the multiplication effect on mouse TM4 cells is increased by 53.57%; and after being compounded with xylonic acid lactone, the compound also has a synergistic capability, so that the proliferation effect on TM3 cells is further improved, and a foundation is laid for treating male reproductive system diseases in the future.

The invention belongs to but not limited to the technical field of biomedicine, and discloses a composition with a cell protection effect and application thereof, the composition comprises five monomers of cycloastragenol, resveratrol, ginsenoside, tetrahydrocurcumin and cellulose, and can also comprise a moisturizing composition and a moisturizing composition. The composition provided by the invention can accurately act on vaginal smooth muscle cells and gland cells, and can be used for recovering or improving endocrine balance by improving cell activity, promoting elastin synthesis and repairing cell injury in multiple ways, improving telomerase activity of a reproductive system and regulating immune response, so that the curative effect of the composition is improved. Various injury factors such as exogenous factors, traction of production machinery and age increase are effectively resisted, and the method has wide application prospects in the fields of postpartum reproductive system rehabilitation, maintenance of normal functions of the reproductive system, prevention and improvement of conditions such as vagina relaxation, dryness and poor injury repair and the like, and prevention and treatment of related diseases of the reproductive system and health care.

The prebiotic formulation is capable of modulating the growth and / or activity of microorganisms in a region of the urogenital system. Such prebiotic formulations can comprise isomaltulose and at least one other prebiotic, such as 1-kestose or lactulose. These modulated microorganisms can be directly related to the health of the urogenital system, and their modulation can be used to prevent, control or treat dysbacteriosis in the region of the urogenital system.

The invention provides a breeding-promoting lactating sow compound feed as well as a preparation method and application thereof. The breeding-promoting lactating sow compound feed comprises the following components in parts by weight: 70-110 parts of a base material, 1-2 parts of calcium salt, 1-3 parts of a functional additive and 1-2 parts of a premix, the functional additive is prepared from the following components in parts by weight: 20 to 40 parts of plant extract, 0.2 to 2 parts of verbascoside, 0.1 to 1 part of geniposide and 0.5 to 2 parts of L-theanine. The compound feed provided by the invention can improve the feed intake of the lactating sows, maintain proper backfat thickness, reduce the weaning loss of the sows and improve the weaning oestrus rate of the sows; excessive free radicals generated by the body can be removed, the balance of a redox system in the body is maintained, oxidative stress is prevented from being generated, the reproductive system of the lactating sow is prevented from being damaged, and the reproductive performance of the sow is improved; and inflammatory factors in the sows can be removed, inflammatory reaction of the sows is avoided, and the reproductive capacity of the lactating sows is improved.

The present application relates to a kind of SGLT2 inhibitor in the preparation for treating hormone receptor low reaction type reproductive system disease in the application of drug, in particular, SGLT2 inhibitor and hormone can improve or enhance the sensitivity and / or for reversing the drug resistance of endocrine therapy drug, such as hormone, can enhance the therapeutic effect of such drug, especially in drug-resistant reproductive system disease and tumor treatment has good application prospect.

The invention relates to an automatic assisted reproduction system based on sound-driven bubble microfluid, and belongs to the field of micro-nano operation robots. Comprising the key steps of focusing, capturing, rotating, three-dimensional reconstruction and evaluation and the like, and the problems of high cost and long period in traditional manual operation are solved. The system utilizes secondary radiation force generated by sound wave driving bubble vibration to perform non-contact accurate control on oocytes or embryos. Meanwhile, multi-angle image capture is realized in combination with a three-degree-of-freedom operation platform, and continuous and stable three-dimensional reconstruction and morphological evaluation of the embryo in a long-period culture process are supported. Wherein the deep learning neural network is responsible for analyzing an embryonic development image in real time, and the intelligent algorithm is used for dynamically optimizing an operation path and parameters, so that the system is ensured to efficiently and accurately complete tasks without manual intervention, and the stability and success rate of operation are remarkably improved.

The invention provides a composition for promoting proliferation of mesenchymal stem cells and / or relieving spermatogonial cell injury as well as a preparation method and application of the composition, and belongs to the technical field of traditional Chinese medicine compositions. The composition is prepared from the following raw materials in parts by weight: 10-20 parts of ginseng, 5-15 parts of maca, 5-10 parts of oyster peptide, 5-15 parts of sika deer penis, 3-8 parts of sika deer blood, 3-8 parts of fresh ginger, 5-8 parts of herba cistanche, 4-10 parts of sea cucumber peptide, 4-8 parts of rhizoma polygonati, 5-10 parts of burdock root, 2-5 parts of fructus lycii powder and 1-3 parts of folium cortex eucommiae. The composition is prepared into a traditional Chinese medicine preparation by adopting a superfine grinding process, and the traditional Chinese medicine preparation has the effects of promoting proliferation of mesenchymal stem cells (MSCs), repairing spermatogonial cell injury caused by oxidative stress (such as chemotherapy and radiation) or aging (such as age-related), reducing the ROS level, improving spermatogenic dysfunction, assisting in treating male infertility and delaying senescence of a reproductive system and a whole body.

The invention discloses a strain of probiotic bacillus subtilis capable of degrading a plurality of mycotoxins. The invention belongs to the technical field of bacillus subtilis, the bacillus subtilis H-1 shows an excellent degradation effect on zearalenone, the ZEN degradation rate of the bacillus subtilis H-1 can reach up to 88.3% under the optimized culture condition, the content of ZEN in feed and food can be effectively reduced, potential threats of mycotoxin to animal and human health are reduced from the source, and the bacillus subtilis H-1 has a good application prospect. The safety of agricultural products and feed is greatly improved, and safe delivery of a food chain is guaranteed; the bacillus subtilis H-1 disclosed by the invention has a remarkable promoting effect on animal health, can improve atrophy conditions of spleen and thymus, enhance immune organ functions, remarkably reduce uterine ovarian coefficient, relieve damage of ZEN to a female reproductive system and guarantee reproductive health of animals; the strain H-1 can generate amylase and cellulase, the enzyme production capacity is good, the enzymes can participate in the decomposition and digestion process of nutrient substances in animal intestinal tracts, the utilization rate of carbohydrates in feed can be increased, absorption of the nutrient substances by animals is promoted, the feed cost is reduced, and the breeding benefits are increased.

The invention discloses application of a caenorhabditis elegans reproductive disorder model to screening of strains promoting reproduction health, and relates to the technical field of biologica.Cyclophosphamide medicine intervention is applied to caenorhabditis elegans, so that the normal reproductive system of caenorhabditis elegans is damaged, and the reproductive disorder model is prepared; then 3985 gene knockout strains in an escherichia coli Keio gene knockout library are utilized, and strains with the reproductive capacity remarkably improved for reproductive disorder are screened; and carrying out homologous gene knockout on the probiotics by using a gene editing technology, and screening out the probiotics with the potential of promoting reproductive health. The reproductive disorder model is stable and repeatable, can be used for screening strains or drugs for improving the reproductive function, and also can be used for screening candidate strains or drugs for reducing the reproductive toxicity of cyclophosphamide. According to the method, an effective tool is provided for screening of reproduction-related probiotic strains or screening of related drugs, and meanwhile, the strains screened based on the model provide new candidate strains for treatment and research of reproductive disorder diseases.

The invention belongs to the technical field of medicines, and discloses application of xylonic acid lactone in preparation of a medicine for enhancing the proliferation capacity of male germ cells. According to the application, it is found for the first time that xylonic acid lactone has multiplication capacity on male germ cells, when the concentration of xylonic acid lactone is 100 [mu] M, the multiplication effect is optimal, the multiplication effect on mouse TM3 cells is increased by 55.84%, and the multiplication effect on mouse TM4 cells is increased by 43.69%; and a foundation is laid for the treatment of male reproductive system diseases in the future.