62 results about "Reproductive system" patented technology

The present invention relates to an oral extract composition comprising Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) extract composition, and its process of preparation. Also relates to the oral extract composition formulation comprising with synergistic combinations of the Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) in suitable doses and at least one nutraceutically and / or pharmaceutically accepted excipient for, improvement, and maintenance of women health more preferably in improving of hot flashes, night sweats, poor sleep, anxiety, sexual dysfunction, mood changes, Genitourinary symptoms in overall improving the quality of life, serum estradiol, progesterone, follicle stimulating hormone (FSH), and cortisol during the period of menopause (perimenopause and menopause). The oral extract composition formulation comprising with synergistic combinations of the Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) in suitable doses and at least one nutraceutically and / or pharmaceutically accepted excipient is used for improving Brain-derived neurotrophic factor (BDNF) levels in women during the period of menopause. The present invention, further related to the extraction process of Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.), also provides the process for the preparation of formulation composition. This invention further relates to the extraction process from Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) either as individual herbs or co-extraction of the two herbs or mixing the extracts at various stages of the individual extracts.

The current invention is in the field of molecular biology / pharmacology and provides novel 3-oxabicyclo[3.3.1]nonene compounds and derivatives that modulate the effects of the classical estrogen receptors alpha and beta (ERalpha and ERbeta) with little to no biological or physiological effects on the G protein-coupled estrogen receptor GPER (also known as GPR30). These compounds may function as agonists and / or antagonists of one or more of the disclosed classical estrogen receptors. Diseases that are mediated through one or more of these receptors include cancer (including but not limited to breast (particularly endocrine or anti-hormone resistant, and for the prevention / reduction of endocrine or anti-hormone resistance), reproductive and other hormone-dependent cancers, leukemia, colon cancer, prostate cancer), reproductive (genito-urological) including endometritis, prostatitis, polycystic ovarian syndrome, bladder control, hormone-related disorders, hearing disorders, cardiovascular conditions including hot flashes and profuse sweating, hypertension, stroke, obesity, osteoporosis, hematologic diseases, vascular diseases or conditions such as venous thrombosis, atherosclerosis, among numerous others and disorders of the central and peripheral nervous system, including depression, insomnia, anxiety, multiple sclerosis, neuropathy, neurodegenerative disorders (such as Parkinson's disease and Alzheimer's disease), as well as inflammatory bowel disease, Crohn's disease, coeliac (celiac) disease and related disorders of the intestine, among numerous others as described herein. A contraceptive indication to prevent or reduce the likelihood of pregnancy after intercourse is a further aspect of the present invention.

The invention relates to a combined mouse and insect killing composition, a combined mouse and insect killing bait and a combined mouse and insect killing method for simultaneously inhibiting reproduction of field mice and killing ectoparasites of the field mice. The combined mouse and insect killing composition comprises ivermectin and atrazine, the weight ratio of the ivermectin to the atrazine is (1-9): (9-90). The mouse and insect combined killing bait comprises the mouse and insect combined killing composition and basic bait. The combined mouse and insect killing method comprises the step of applying the combined mouse and insect killing composition or the combined mouse and insect killing bait to wild mice. The mouse and insect combined killing composition and bait can control the population density of mice by inhibiting the reproductive system function of the mice in the field on the premise of not directly killing the mice, and meanwhile effectively kill parasites such as fleas, ticks and the like on the body surfaces of the mice, and block a disease transmission chain. Therefore, the combined mouse and insect killing composition and the bait have the combined control effects of inhibiting reproduction of field mice and killing ectoparasites of the field mice.

The present application relates to a kind of SGLT2 inhibitor in the preparation for treating hormone receptor low reaction type reproductive system disease in the application of drug, in particular, SGLT2 inhibitor and hormone can improve or enhance the sensitivity and / or for reversing the drug resistance of endocrine therapy drug, such as hormone, can enhance the therapeutic effect of such drug, especially in drug-resistant reproductive system disease and tumor treatment has good application prospect.

The invention discloses application of a caenorhabditis elegans reproductive disorder model to screening of strains promoting reproduction health, and relates to the technical field of biologica.Cyclophosphamide medicine intervention is applied to caenorhabditis elegans, so that the normal reproductive system of caenorhabditis elegans is damaged, and the reproductive disorder model is prepared; then 3985 gene knockout strains in an escherichia coli Keio gene knockout library are utilized, and strains with the reproductive capacity remarkably improved for reproductive disorder are screened; and carrying out homologous gene knockout on the probiotics by using a gene editing technology, and screening out the probiotics with the potential of promoting reproductive health. The reproductive disorder model is stable and repeatable, can be used for screening strains or drugs for improving the reproductive function, and also can be used for screening candidate strains or drugs for reducing the reproductive toxicity of cyclophosphamide. According to the method, an effective tool is provided for screening of reproduction-related probiotic strains or screening of related drugs, and meanwhile, the strains screened based on the model provide new candidate strains for treatment and research of reproductive disorder diseases.

The invention belongs to the technical field of feed additive preparation, and particularly discloses a fermented stevia rebaudiana composition and application thereof in preparation of a feed additive. The fermented stevia rebaudiana composition is prepared from the following components in parts by weight: 25-35 parts of stevia rebaudiana, 12-14 parts of corn straw, 10-30 parts of soybean meal, 2-3 parts of honeysuckle, 6-8 parts of Chinese yam, 1-2 parts of hawthorn, 4-7 parts of bran and 1-2 parts of dandelion. The invention discloses a fermented stevia rebaudiana composition and application thereof in preparation of a feed additive, the fermented stevia rebaudiana composition has high content of total flavonoids and total phenols, when applied to laying hen breeding, the fermented stevia rebaudiana composition can significantly enhance the oxidation resistance of organisms and effectively inhibit inflammatory response, and is beneficial to the health of reproductive systems; therefore, the production performance of laying hens is obviously improved and the egg quality is improved.

The invention relates to the technical field of traditional Chinese medicine, and discloses a traditional Chinese medicine composition for treating perimenopausal syndrome, which is composed of podophyllum hexandrum, lagotis, honeysuckle fruit, bamboo shavings, pilose antler and sea-buckthorn. The composition takes podophyllum hexandrum as a monarch drug, sea-buckthorn and honeysuckle fruit as ministerial drugs to enhance the effects of promoting blood circulation and regulating menstruation, cornu cervi pantotrichum for replenishing essence and blood, warming yang and dispelling cold, and bamboo shavings and lagotis herb as adjuvant drugs for cooling blood and clearing heat, so that a three-dimensional system of promoting blood circulation, tonifying and clearing heat is formed. It is verified that the composition can relieve uterine atrophy, improve organic decline of a reproductive system, reduce whole blood viscosity and abnormally-increased leukocyte number, inhibit inflammation, accurately adjust serum E2, LH, PROG and AMH levels so as to remodel hormone balance and avoid side effects of exogenous hormones. The composition is based on the advantages of Tibetan medicines and the multi-target effect of natural medicinal materials, conforms to the modern research and development trend and is high in clinical transformation value.

The present invention also relates to methods for assessing the risk of pregnancy loss or embryo implantation failure, and to methods for monitoring or evaluating the effectiveness of treatments to reduce the risk of pregnancy loss or embryo implantation failure using specific biomarkers. The present invention also relates to the use of these biomarkers in methods for diagnosing reproductive disorders in individuals, as well as methods for treating reproductive disorders. Furthermore, the biomarkers can further be used in methods for selecting patients for treatment to reduce the risk of embryo implantation failure or miscarriage. The present invention also relates to kits for use in any of the methods described herein.

The present application relates to the technical field of animal breeding, and discloses a compound nutritional health supplement for laying hens in the egg production period and a preparation and application thereof, which comprises the following raw materials in mass fractions: motherwort 1200-1400 parts, radix astragali 150-250 parts, radix codonopsis 80-120 parts, betaine hydrochloride 500-700 parts, butyric acid clostridium 50-70 parts, bacillus licheniformis 90-110 parts, vitamin acetate 3-5 parts, coated 25-hydroxy-cholecalciferol 1-2 parts, vitamin E acetate 15-25 parts, and rice husk powder 0-411 parts. The formula can scientifically and comprehensively regulate the digestion and absorption of nutrients, immune function and reproductive system health of laying hens, improve the eggshell quality, egg weight and nutritional quality of egg products, has stable effect and strong universality, greatly reduces the side effects and body burden caused by long-term medication while ensuring the effect, and is more suitable for the concept of healthy breeding; the health level of the body is comprehensively improved, the intestinal flora balance is maintained by probiotics, the immunity and stress resistance of laying hens are overall enhanced, the nutrient utilization rate is improved, and healthy high yield is achieved.

The invention belongs to the technical field of traditional Chinese medicine pharmacy, and provides a freeze-dried powder pharmaceutical composition for impotence and a preparation method thereof, and the freeze-dried powder pharmaceutical composition is prepared from the following traditional Chinese medicinal materials as raw materials in parts by weight: 5-10 parts of pilose antler, 5-10 parts of hippocampus, 10-20 parts of fructus lycii, 10-20 parts of Chinese yam and 10-20 parts of semen cuscutae. Through the synergistic effect of the pilose antler, the hippocampus, the fructus lycii and other traditional Chinese medicinal materials, the traditional Chinese medicine composition can tonify kidney yang, benefit essence and blood, improve impotence symptoms, strengthen muscles and bones, relieve soreness, weakness and pain of the waist and integrally regulate the male reproductive system and body functions; the freeze-dried powder technology is adopted for drying at low temperature, active ingredients such as pilose antler polypeptide and polysaccharide are reserved to the maximum extent, and oxidation or degradation of the active ingredients is avoided; after moisture is removed, the growth of microorganisms can be inhibited, and the shelf life is prolonged; and the freeze-dried powder has a loose and porous structure, so that the re-dissolving speed is high, and the active ingredients exist in a nearly natural state and are more easily absorbed by gastrointestinal mucosa.

The subject of the application is a dietary supplement containing 2.5 - 7 wt.% indole-3-carbinol, 2 - 6 wt.% epigallocatechin gallate, 30 - 70 wt.% myo-inositol, 6 - 12.5 wt.% N-acetylcysteine, 2.5 - 7 wt.% quercetin, 5 - 8.5 wt.% Omega-3 acid, 5 - 8.5 wt.% alphalipoic acid, 2 - 6 wt.% vitamin C, 1 - 5 wt.% resveratrol, 0.01 - 0.2 wt.% vitamin D3, 0.5 - 3.5 wt.% vitamin E, 0.2 - 15 wt.% alpha-lactalbumin, 0.04 - 20 wt.% curcumin, 0.2 – 15% w / w D-chiroinositol, 0.2- 24% w / w inulin, a probiotic consisting of a mixture of strains of the Lactobacillus, Bifidobacterium and Saccharomyces genera for patients with reproductive system diseases supporting the reduction of estrogen levels and estrogen and progesterone receptors.

This invention discloses a compound moxa stick for warming yang and unblocking obstruction, its preparation method, and its application in improving reproductive system function. It belongs to the field of external preparations of traditional Chinese medicine. Addressing the problems of limited improvement effects of pure moxa sticks, lack of systematic design in compound moxa stick formulations, unclear synergistic effects between components, large fluctuations in conditioning effects, and difficulty in balancing conditioning effects and safety, this invention uses specific weight proportions of Artemisia argyi, Cyperus rotundus, Alpinia galanga, Cinnamomum cassia, Zingiber officinale, Illicium verum, Cinnamomum cassia twig, Spatholobus suberectus, Caesalpinia sappan, Smilax glabra, Euonymus fortunei, Citrus aurantium, Amomum villosum, Citrus reticulata peel, and Atractylodes lancea to prepare a compound moxa stick. The components synergistically enhance each other, and this product is used to prepare a moxibustion intervention product for improving the reproductive function of mammals. It can stably improve female ovarian reserve function and male asthenospermia, simultaneously regulate reproductive-related hormone levels, repair pathological damage to reproductive organs, and improve the quality of reproductive cells.

The invention discloses a traditional Chinese medicine formula with a reproductive system radiation damage protection effect as well as a preparation method and application of the traditional Chinese medicine formula. The traditional Chinese medicine formula comprises the following components in parts by mass: 15-30 parts of Chinese yam, 6-15 parts of dogwood, 10-30 parts of astragalus membranaceus, 10-30 parts of prepared rehmannia root, 10-15 parts of spina date seed, 6-15 parts of fructus psoraleae, 5-15 parts of fructus lycii and 3-9 parts of rhodiola rosea. In the traditional Chinese medicine formula provided by the invention, all the components have a synergistic effect, so that the injury of ionizing radiation to a reproductive system can be effectively relieved, the pathological change of testis tissues is remarkably improved, sperm quality parameters are improved, the apoptosis process of testis cells is inhibited, the injury caused by oxidative stress is repaired, and the DNA injury degree is reduced; therefore, the technical defects of high toxicity, high cost, insufficient protective effect on the reproductive system and the like of the existing radiation protective agent are overcome.

The invention discloses a method for analyzing the pharmacodynamic material basis and action mechanism of a laying hen Bao traditional Chinese medicine. The method specifically comprises the following steps: (1) identifying chemical components in the laying hen Bao by UHPLC-HRMS (Ultra High Performance Liquid Chromatography-High Resolution Mass Spectrometry); (2) screening a core target spot of the laying hen for treating poultry reproductive system diseases; (3) obtaining the drug effect material basis of the laying hen feed; and (4) constructing a'laying hen bao-effective component-core target group-signal channel 'regulation network. According to the method, a traditional Chinese medicine component chemical analysis technology and a network pharmacology method are combined, a systematic and multi-dimensional analysis tool is provided for research on the traditional Chinese medicine effect material basis of the traditional Chinese medicine compound laying hen Bao, the chemical components in the traditional Chinese medicine compound laying hen Bao can be effectively recognized, the medicine effect material basis can be screened, target spots and channels related to the medicine effect can be recognized, and the method is suitable for popularization and application. A new thought is provided for revealing the scientific connotation of'multi-component, multi-target and multi-channel 'of the traditional Chinese medicine compound laying hen bao.

The invention relates to the technical field of microorganisms, in particular to lactobacillus mucilaginosus for inhibiting multiple female vaginal pathogenic bacteria and application of the lactobacillus mucilaginosus. According to the present invention, the fermentation lactobacillus mucus VL9 is separated from the female genital tract at the healthy childbearing age, and the preservation number of the fermentation lactobacillus mucus VL9 is CGMCC No.36415; the strain has good human body compatibility and environmental adaptability, can effectively maintain the acidic environment of the vagina, and has an efficient bacteriostatic effect on pathogenic bacteria in a female urogenital system. The in-vitro culture condition of the fermented lactobacillus mucus VL9 is simple, the cost of the culture medium is low, the method is suitable for a conventional production system, and large-scale preparation can be realized on the premise that the cost is not obviously increased.

The application belongs to the technical field of medicine, and discloses application of uridine-5' monophosphate and a compound thereof in preparation of a medicine for enhancing the proliferation ability of male reproductive cells. It is found for the first time that the uridine-5' monophosphate has the proliferation ability on the male reproductive cells, and the proliferation effect is best when the concentration of the uridine-5' monophosphate is 10 μM, the proliferation effect on the mouse TM3 cells is increased by 52.87% compared with a control, and the proliferation effect on the mouse TM4 cells is increased by 53.57%. In addition, the uridine-5' monophosphate has a synergistic ability when being compounded with xylonic acid lactone, and further improves the proliferation effect on the TM3 cells, thereby laying a foundation for treatment of male reproductive system diseases in the future.

The invention discloses a premature ovarian failure rat animal model building method based on enterovirus group transplantation, and particularly relates to the technical field of animal model building. According to the invention, the enterovirus group of a premature ovarian failure patient is subjected to in-vitro extraction and purification, and then is transplanted into a female rat, so that a new experimental model is provided for researching the interaction between the enterovirus group and the premature ovarian failure; meanwhile, a new way is opened up for further revealing the research on the complex relation between intestinal microorganisms and female reproductive health. In addition, the model is expected to provide an experimental basis for developing a novel treatment strategy for premature ovarian failure. The method aims to deeply explore the relationship between the enterovirus / bacteriophage group and female reproductive system diseases, especially premature ovarian failure.

This invention provides a method for assessing the reproductive adaptability of natural enemies to feed by using ovarian development indicators, including: (1) establishing an experimental population: natural enemies are fed different prey or feed and are raised and bred under environmental conditions of 27±1℃, 70±5% relative humidity, and 16L:8D photoperiod; (2) dissection of the female adult reproductive system: the reproductive system is completely removed by anesthesia, wing removal, and separation of the dorsal plate; (3) determination of ovarian development indicators at key ages: the ovaries of female adults at key ages and under different feeds are dissected, and parameters such as the number of eggs, ovarian tube length, and mature egg volume are counted. The ovarian development progress of *Triplophysa fasciata* under different feeds is compared to assess reproductive adaptability.

The application provides a multi-organ joint diagnosis system for the female reproductive system, comprising: a tissue area extraction module that extracts the tissue area in each slide image and performs contour detection and instance segmentation on the tissue area of each slide image; a tissue attribution determination module that determines the attribution of each slide based on the contour detection and instance segmentation results, and determines the corresponding relationship between the sampling site number and the slide number; an image slicing module that analyzes each slide according to the sampling site number and the slide number to determine a combined slide, and performs image slicing processing on the combined slide; and a joint diagnosis module that collects the image areas of the same sampling site according to the tissue attribution determination results and the image slicing processing results, and performs independent pathological diagnosis on each sampling site image area based on an AI diagnosis model. The application realizes intelligent classification and splitting of the slide and tissue images, independent analysis of each sampling site, and avoids misdiagnosis and missed diagnosis caused by model misuse.

Embodiments of the present invention provide GYN pathology simulation models for surgical training. These models are energy-compatible models emulating the tissue-based diseases of the female reproductive system to allow the surgical trainees and surgeons to practice advanced OB / GYN surgical skills. One simulated GYN model includes an electrically conductive elongated tube encapsulating a mass of non-conductive material. The elongated tube having a sidewall with an inner surface and outer surface extending between a proximal end and distal end. The sidewall is configured to have a cavity with a specific volume to yield an external protuberance when filled with the mass of non-conductive material. Another simulated GYN model includes a fluid-filled cystic body encapsulated within an electrically conductive bulbous hollow structure. The fluid-filled cystic body is selectively adhered to the bulbous hollow structure in at least one or more regions, thereby creating a plane for a combination of blunt and sharp dissection.

A system for sensing one or more physiological traits and obstetric conditions, such as a fertility phase, pregnancy, labor, post-partum conditions, and other conditions related to the reproductive system of the patient. The system may use the one or more physiological traits sensed to define one or more patient attributes for the patient, such as a hormone level, heart rate, blood pressure, respiration rate, temperature, oxygen saturation level, uterine contractions, fluid level, and / or other patient attributes. The system is configured to compare the one or more patient attributes to one or more attribute signs describing a threshold for the one or more patient attributes. The system is configured to issue a communication to the patient and / or a clinician based on the comparisons. The system may be configured to assess and indicate reproductive phases for the patient over a life-cycle from the fertility phase to the post-partum phase.

The invention relates to methods for assessing the risk of miscarriage or embryo implantation failure, and also for monitoring or evaluating the effect of a treatment to reduce the risk of miscarriage or embryo implantation failure using specific biomarkers. The invention also relates to the use of these biomarkers in methods of diagnosing a reproductive disorder in an individual, and also to methods of treating a reproductive disorder. In addition, the biomarkers can further be used in methods of selecting patients for treatment to reduce risk of embryo implantation failure or miscarriage. The invention also relates to kits for use in any of the methods described herein.

This invention provides a method to increase the egg production of breeding geese. The method utilizes artificial light control during the breeding period of replacement geese to promote the full development of their reproductive system, increase ovarian weight during the first laying period, and thus increase the egg production and egg weight in the first laying year. This method is applicable to replacement geese before their first laying period. It increases ovarian weight at the onset of the first laying period, ensuring full development of the reproductive system and increasing the total egg production during that period. Furthermore, this method promotes reproductive system development, resulting in heavier geese entering the first laying period and further increasing egg weight.

Described herein are contraceptive devices comprising a torus-shaped elastomer body and a bioactive agent coupled into the elastomer body. The device may be inserted by a subject in need thereof into the vaginal region of the female reproductive system for prophylactic and / or emergency contraception.

The invention provides a risk assessment method and system for noninvasive dynamic monitoring of diseases of a urinary and male reproductive system, and relates to the technical field of urology andrology. By collecting multi-dimensional physiological data and combining an intelligent algorithm to deeply analyze the data, potential disease signals can be automatically identified in a short time, and the risk assessment method and system can be applied to the field of non-invasive dynamic monitoring of diseases of the urinary and male reproductive system. And personalized disease risk prediction is provided based on historical data, the physiological state of the patient is analyzed and synthesized in real time, a monitoring strategy is dynamically adjusted, and a personalized disease prediction result is provided according to the health condition of the patient and medical record data. Compared with a traditional technology which depends on a single data source, the method has the advantages that through comprehensive analysis of multi-dimensional data, the defect that the traditional method lacks dynamic monitoring is overcome, and limitation caused by excessive dependence of the single data source can be avoided.

A technical formulation for the active absorption of amino acids by the human reproductive system,which technical formulation is prepared by physically extracting tea components and mixing same with sodium chloride. The technical formulation isbased on the regeneration and repair of the human nervous system and immune system,and is used in the treatment of various typesof inflammation,cancer,etc.

Hydrolyzed collagen compositions are described that are used for treatment of impaired tissue including mucosal tissue or to prevent damage to healthy tissue. These compositions function to treat mucosal tissues found in the digestive, urinary, respiratory and reproductive systems. Oral or topical, site-specific delivery of the compositions may be via liquid, spray, gel, powder, tablet, capsule, or sheet form.

The invention relates to a flora prediction model for detecting premature delivery risk and a kit and application thereof. Through early-stage mNGS data collection and analysis, premature related strains are obtained, and through a large number of experimental screening and optimization, a set of optimal primer probe group is finally determined. The invention relates to a premature delivery risk calculation method, which comprises the following steps of: selecting 12 floras, namely lactobacillus crispatus, lactobacillus gasseri, lactobacillus inertus, lactobacillus jensenii, escherichia coli, enterococcus faecalis, enterobacter aerogenes, group B hemolytic streptococcus, ureaplasma parvum, chlamydia trachomatis, diplococcus gonorrhoeae and gardnerella vaginalis, and establishing a fluorescent quantitative PCR (Polymerase Chain Reaction) method and a premature delivery risk calculation model aiming at the detection of the 12 floras. Compared with an existing detection method, the method is simple, convenient, rapid, high in sensitivity and high in specificity, the false positive and false negative risk is reduced, and the purpose of batch detection is achieved. Clinically, the change of microbial flora in the reproductive system of a pregnant woman can be rapidly detected, corresponding treatment measures are taken, the risk of PTB occurrence is reduced, and the kit has a good application prospect.

The present application relates to the preparation and application field of biological peptide, and particularly relates to a plectinum peptide and application of the plectinum peptide in preparation of a product for repairing male reproductive system damage function. The present application utilizes green controllable enzymolysis technology to obtain protein polypeptides with nutritional health care and medicinal values, and further researches on the basis to obtain an active peptide sequence with high biological activity, obtains the active peptide with high purity through a chemical synthesis mode, and verifies the biological activity of the peptide by using mouse spermatogonia.

The application belongs to the technical field of reproductive health, and particularly relates to a new application of a testicular metabolite 2-n-propylthiazolidine-4-carboxylic acid (PTCA), and the 2-n-propylthiazolidine-4-carboxylic acid is used for preparing a drug for treating testicular spermatogenic disorder induced by AFB1. The PTCA can promote the secretion of testosterone of testicular interstitial cells, activate the PI3K / AKT / NRF2 antioxidant signaling pathway in testicular tissue, relieve testicular injury induced by AFB1, and reduce the ROS level in testicular tissue. The application discloses, for the first time, the important role of the PTCA as a new testicular metabolic marker and protective agent in the male reproductive system, provides a new insight into the reproductive toxicity mechanism of AFB1, and lays an experimental foundation for the application of metabolites to the intervention strategy of male spermatogenic disorder.