106 results about "Reproductive system" patented technology

The invention relates to the field of preparation and application of biological peptides, in particular to a hippocampal swelling peptide and application thereof in preparation of functional products for repairing male reproductive system injury. A green controllable enzymolysis technology is utilized to obtain protein polypeptide with nutritional, health-care and medicinal values, five active peptide sequences with high biological activity are obtained through further research on the basis, the high-purity active peptide is obtained through a chemical synthesis mode, and the biological activity of the peptide is verified through mouse spermatogonium.

The invention relates to the technical field of biomedical treatment, in particular to bifidobacterium longum subsp. Longum and application thereof in drugs related to reproductive system diseases. The invention provides a strain of Bifidobacterium longum subsp. Longum NCU-06, which is preserved in China General Microbiological Culture Collection Center (CGMCC), the preservation address is No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing, the preservation date is January 18, 2023, and the preservation number is CGMCC No.26491. The invention also provides a method for preparing the Bifidobacterium longum subsp. Longum NCU-06. The bifidobacterium longum subsp. Longum NCU-06 has a treatment effect on various female reproductive system diseases, for example, the bifidobacterium longum subsp. Longum NCU-06 can be used for treating endometriosis, ovarian cancer, ovarian cancer parneoplastic thrombocythemia and ovarian hyperstimulation syndrome.

The invention provides an ovary-targeting ROS response type SS31 nano-particle and a preparation method and application thereof, and belongs to the field of biomedicine.The ovary-targeting ROS response type SS31 nano-particle is constructed by utilizing a porous metal organic framework to carry hyaluronic acid and utilizing an ROS response type thioketone linker to be combined with mitochondrial targeting peptide SS31, and the ovary-targeting ROS response type SS31 nano-particle is used for preparing the ovary-targeting ROS response type SS31 nano-particle. And the SS31 is targeted and delivered to the ovarian tissue. The nanoparticles target ovary and slowly release SS31 under the action of ROS, so that oxidative stress of oocytes and granular cells caused by female reproductive system diseases such as premature ovarian failure, polycystic ovarian syndrome and the like is reduced, and the mitochondrial function of the oocytes and the granular cells is improved; and a foundation is laid for the subsequent clinical treatment of diseases related to the mitochondrial dysfunction of the female reproductive system by using the SS31.

The invention provides a teaching interaction processing method and system applied to an intelligent online practical training platform. The method comprises the following steps: firstly, acquiring a training scene data set comprising operation process simulation data (corresponding to gynecological examination and related medical skill standard operation processes) and anatomical structure model data (constructed based on medical image data and comprising three-dimensional structure feature information of a female reproductive system), and then carrying out interactive content generation processing on the training scene data set; generating interactive teaching content including operation step guide information and a three-dimensional dissection display model by combining teaching logic rules, and then receiving interactive operation data (corresponding operation simulation behaviors including operation action time sequence records and spatial position coordinates) of a user on a platform; then training effect evaluation processing is carried out on the interactive operation data and the interactive teaching content to generate a training evaluation result, and finally personalized feedback content is generated according to the evaluation result and pushed to a user interface to guide a user to adjust a training behavior, so that the medical training teaching quality and efficiency are improved.

The present invention belongs to the field of traditional Chinese medicines, and particularly relates to Leixihaokang, a preparation method therefor, and use thereof. The Leixihaokang of the present invention is prepared from the following active pharmaceutical ingredients in parts by weight: 10 parts of Tripterygium glycosides and 0.1-1.3 parts of Artemisia annua extract. According to the present invention, animal experiments prove that the Leixihaokang can ameliorate renal damage in nephrotic syndrome caused by adriamycin, reduce the occurrence of proteinuria, and reduce the apoptosis of renal tissue cells. Meanwhile, the Leixihaokang of the present invention has a good inhibitory effect on renal, hepatic, splenic, and cardiac toxicity in the treatment process of nephrotic syndrome. According to the present invention, animal experiments also prove that the Leixihaokang can ameliorate skin injury in imiquimod-induced psoriasis, reduce inflammatory infiltration and alleviate skin damage. Meanwhile, the Leixihaokang has a certain degree of inhibitory effect on the hepatic and reproductive system toxicity in the treatment process of psoriasis.

The present invention relates to an oral extract composition comprising Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) extract composition, and its process of preparation. Also relates to the oral extract composition formulation comprising with synergistic combinations of the Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) in suitable doses and at least one nutraceutically and / or pharmaceutically accepted excipient for, improvement, and maintenance of women health more preferably in improving of hot flashes, night sweats, poor sleep, anxiety, sexual dysfunction, mood changes, Genitourinary symptoms in overall improving the quality of life, serum estradiol, progesterone, follicle stimulating hormone (FSH), and cortisol during the period of menopause (perimenopause and menopause). The oral extract composition formulation comprising with synergistic combinations of the Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) in suitable doses and at least one nutraceutically and / or pharmaceutically accepted excipient is used for improving Brain-derived neurotrophic factor (BDNF) levels in women during the period of menopause. The present invention, further related to the extraction process of Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.), also provides the process for the preparation of formulation composition. This invention further relates to the extraction process from Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) either as individual herbs or co-extraction of the two herbs or mixing the extracts at various stages of the individual extracts.

The present invention provides a probiotic active antibacterial tablet for preventing and treating female reproductive system infection and a preparation method thereof. The present invention is a probiotic active antibacterial tablet for preventing and treating female reproductive system infection, comprising the following raw materials in parts by weight: 1.8-2.5 parts of Lactobacillus reuteri, 1.0-1.2 parts of Lactobacillus rhamnosus, 1.2-1.7 parts of Lactobacillus crispatus, 0.5-0.8 parts of Lactobacillus gasseri, 1.0-1.5 parts of stachyose, 0.8-1.2 parts of inulin, and 2.5-3 parts of plant extract, wherein the plant extract is prepared from the following raw materials: Bletilla striata, Chinese tallow tree leaf, Gentiana scabra, and grapefruit seed. The probiotic active antibacterial tablet prepared by the present invention has a significant inhibitory effect on IGFBP7 protein, can effectively prevent and treat female reproductive system infection, and has good tolerance and safety.

The current invention is in the field of molecular biology / pharmacology and provides novel 3-oxabicyclo[3.3.1]nonene compounds and derivatives that modulate the effects of the classical estrogen receptors alpha and beta (ERalpha and ERbeta) with little to no biological or physiological effects on the G protein-coupled estrogen receptor GPER (also known as GPR30). These compounds may function as agonists and / or antagonists of one or more of the disclosed classical estrogen receptors. Diseases that are mediated through one or more of these receptors include cancer (including but not limited to breast (particularly endocrine or anti-hormone resistant, and for the prevention / reduction of endocrine or anti-hormone resistance), reproductive and other hormone-dependent cancers, leukemia, colon cancer, prostate cancer), reproductive (genito-urological) including endometritis, prostatitis, polycystic ovarian syndrome, bladder control, hormone-related disorders, hearing disorders, cardiovascular conditions including hot flashes and profuse sweating, hypertension, stroke, obesity, osteoporosis, hematologic diseases, vascular diseases or conditions such as venous thrombosis, atherosclerosis, among numerous others and disorders of the central and peripheral nervous system, including depression, insomnia, anxiety, multiple sclerosis, neuropathy, neurodegenerative disorders (such as Parkinson's disease and Alzheimer's disease), as well as inflammatory bowel disease, Crohn's disease, coeliac (celiac) disease and related disorders of the intestine, among numerous others as described herein. A contraceptive indication to prevent or reduce the likelihood of pregnancy after intercourse is a further aspect of the present invention.

The invention relates to a combined mouse and insect killing composition, a combined mouse and insect killing bait and a combined mouse and insect killing method for simultaneously inhibiting reproduction of field mice and killing ectoparasites of the field mice. The combined mouse and insect killing composition comprises ivermectin and atrazine, the weight ratio of the ivermectin to the atrazine is (1-9): (9-90). The mouse and insect combined killing bait comprises the mouse and insect combined killing composition and basic bait. The combined mouse and insect killing method comprises the step of applying the combined mouse and insect killing composition or the combined mouse and insect killing bait to wild mice. The mouse and insect combined killing composition and bait can control the population density of mice by inhibiting the reproductive system function of the mice in the field on the premise of not directly killing the mice, and meanwhile effectively kill parasites such as fleas, ticks and the like on the body surfaces of the mice, and block a disease transmission chain. Therefore, the combined mouse and insect killing composition and the bait have the combined control effects of inhibiting reproduction of field mice and killing ectoparasites of the field mice.

The invention belongs to but not limited to the technical field of biomedicine, and discloses a composition with a cell protection effect and application thereof, the composition comprises five monomers of cycloastragenol, resveratrol, ginsenoside, tetrahydrocurcumin and cellulose, and can also comprise a moisturizing composition and a moisturizing composition. The composition provided by the invention can accurately act on vaginal smooth muscle cells and gland cells, and can be used for recovering or improving endocrine balance by improving cell activity, promoting elastin synthesis and repairing cell injury in multiple ways, improving telomerase activity of a reproductive system and regulating immune response, so that the curative effect of the composition is improved. Various injury factors such as exogenous factors, traction of production machinery and age increase are effectively resisted, and the method has wide application prospects in the fields of postpartum reproductive system rehabilitation, maintenance of normal functions of the reproductive system, prevention and improvement of conditions such as vagina relaxation, dryness and poor injury repair and the like, and prevention and treatment of related diseases of the reproductive system and health care.

The present application relates to a kind of SGLT2 inhibitor in the preparation for treating hormone receptor low reaction type reproductive system disease in the application of drug, in particular, SGLT2 inhibitor and hormone can improve or enhance the sensitivity and / or for reversing the drug resistance of endocrine therapy drug, such as hormone, can enhance the therapeutic effect of such drug, especially in drug-resistant reproductive system disease and tumor treatment has good application prospect.

The invention relates to an automatic assisted reproduction system based on sound-driven bubble microfluid, and belongs to the field of micro-nano operation robots. Comprising the key steps of focusing, capturing, rotating, three-dimensional reconstruction and evaluation and the like, and the problems of high cost and long period in traditional manual operation are solved. The system utilizes secondary radiation force generated by sound wave driving bubble vibration to perform non-contact accurate control on oocytes or embryos. Meanwhile, multi-angle image capture is realized in combination with a three-degree-of-freedom operation platform, and continuous and stable three-dimensional reconstruction and morphological evaluation of the embryo in a long-period culture process are supported. Wherein the deep learning neural network is responsible for analyzing an embryonic development image in real time, and the intelligent algorithm is used for dynamically optimizing an operation path and parameters, so that the system is ensured to efficiently and accurately complete tasks without manual intervention, and the stability and success rate of operation are remarkably improved.

The invention provides a composition for promoting proliferation of mesenchymal stem cells and / or relieving spermatogonial cell injury as well as a preparation method and application of the composition, and belongs to the technical field of traditional Chinese medicine compositions. The composition is prepared from the following raw materials in parts by weight: 10-20 parts of ginseng, 5-15 parts of maca, 5-10 parts of oyster peptide, 5-15 parts of sika deer penis, 3-8 parts of sika deer blood, 3-8 parts of fresh ginger, 5-8 parts of herba cistanche, 4-10 parts of sea cucumber peptide, 4-8 parts of rhizoma polygonati, 5-10 parts of burdock root, 2-5 parts of fructus lycii powder and 1-3 parts of folium cortex eucommiae. The composition is prepared into a traditional Chinese medicine preparation by adopting a superfine grinding process, and the traditional Chinese medicine preparation has the effects of promoting proliferation of mesenchymal stem cells (MSCs), repairing spermatogonial cell injury caused by oxidative stress (such as chemotherapy and radiation) or aging (such as age-related), reducing the ROS level, improving spermatogenic dysfunction, assisting in treating male infertility and delaying senescence of a reproductive system and a whole body.

The invention discloses a strain of probiotic bacillus subtilis capable of degrading a plurality of mycotoxins. The invention belongs to the technical field of bacillus subtilis, the bacillus subtilis H-1 shows an excellent degradation effect on zearalenone, the ZEN degradation rate of the bacillus subtilis H-1 can reach up to 88.3% under the optimized culture condition, the content of ZEN in feed and food can be effectively reduced, potential threats of mycotoxin to animal and human health are reduced from the source, and the bacillus subtilis H-1 has a good application prospect. The safety of agricultural products and feed is greatly improved, and safe delivery of a food chain is guaranteed; the bacillus subtilis H-1 disclosed by the invention has a remarkable promoting effect on animal health, can improve atrophy conditions of spleen and thymus, enhance immune organ functions, remarkably reduce uterine ovarian coefficient, relieve damage of ZEN to a female reproductive system and guarantee reproductive health of animals; the strain H-1 can generate amylase and cellulase, the enzyme production capacity is good, the enzymes can participate in the decomposition and digestion process of nutrient substances in animal intestinal tracts, the utilization rate of carbohydrates in feed can be increased, absorption of the nutrient substances by animals is promoted, the feed cost is reduced, and the breeding benefits are increased.

The invention discloses application of a caenorhabditis elegans reproductive disorder model to screening of strains promoting reproduction health, and relates to the technical field of biologica.Cyclophosphamide medicine intervention is applied to caenorhabditis elegans, so that the normal reproductive system of caenorhabditis elegans is damaged, and the reproductive disorder model is prepared; then 3985 gene knockout strains in an escherichia coli Keio gene knockout library are utilized, and strains with the reproductive capacity remarkably improved for reproductive disorder are screened; and carrying out homologous gene knockout on the probiotics by using a gene editing technology, and screening out the probiotics with the potential of promoting reproductive health. The reproductive disorder model is stable and repeatable, can be used for screening strains or drugs for improving the reproductive function, and also can be used for screening candidate strains or drugs for reducing the reproductive toxicity of cyclophosphamide. According to the method, an effective tool is provided for screening of reproduction-related probiotic strains or screening of related drugs, and meanwhile, the strains screened based on the model provide new candidate strains for treatment and research of reproductive disorder diseases.

The invention belongs to the technical field of feed additive preparation, and particularly discloses a fermented stevia rebaudiana composition and application thereof in preparation of a feed additive. The fermented stevia rebaudiana composition is prepared from the following components in parts by weight: 25-35 parts of stevia rebaudiana, 12-14 parts of corn straw, 10-30 parts of soybean meal, 2-3 parts of honeysuckle, 6-8 parts of Chinese yam, 1-2 parts of hawthorn, 4-7 parts of bran and 1-2 parts of dandelion. The invention discloses a fermented stevia rebaudiana composition and application thereof in preparation of a feed additive, the fermented stevia rebaudiana composition has high content of total flavonoids and total phenols, when applied to laying hen breeding, the fermented stevia rebaudiana composition can significantly enhance the oxidation resistance of organisms and effectively inhibit inflammatory response, and is beneficial to the health of reproductive systems; therefore, the production performance of laying hens is obviously improved and the egg quality is improved.

An apparatus (100) suitable for delivering a fertilized egg or embryo into a maternal uterine endometrium in humans or any other mammalian species, comprising a body (110) configured to fit within a lumen of the female reproductive system. The body (110) comprises one or more lumens extending from a proximal end (130) of the body (110) to a distal portion of the body (110) and having a distal opening (150) at the distal portion of the body (110), wherein a first lumen (120) of the one or more lumens slidably receives an inner body (160) having a distal end suitable for penetrating the endometrial epithelium. The inner body (160) comprises an inner lumen for receiving a fertilized egg. An actuator (195) is operable to expel the fertilized egg from the inner lumen. A covering layer (170a) at least partially covers the distal opening of at least one lumen of the one or more lumens and at least partially covers the distal opening (150) of the first lumen (120) and the inner body (160) is configured to perforate through the covering layer (170a) when the inner body (160) is advanced out from the distal opening (150) of the body (110).

The invention relates to the technical field of traditional Chinese medicine, and discloses a traditional Chinese medicine composition for treating perimenopausal syndrome, which is composed of podophyllum hexandrum, lagotis, honeysuckle fruit, bamboo shavings, pilose antler and sea-buckthorn. The composition takes podophyllum hexandrum as a monarch drug, sea-buckthorn and honeysuckle fruit as ministerial drugs to enhance the effects of promoting blood circulation and regulating menstruation, cornu cervi pantotrichum for replenishing essence and blood, warming yang and dispelling cold, and bamboo shavings and lagotis herb as adjuvant drugs for cooling blood and clearing heat, so that a three-dimensional system of promoting blood circulation, tonifying and clearing heat is formed. It is verified that the composition can relieve uterine atrophy, improve organic decline of a reproductive system, reduce whole blood viscosity and abnormally-increased leukocyte number, inhibit inflammation, accurately adjust serum E2, LH, PROG and AMH levels so as to remodel hormone balance and avoid side effects of exogenous hormones. The composition is based on the advantages of Tibetan medicines and the multi-target effect of natural medicinal materials, conforms to the modern research and development trend and is high in clinical transformation value.

The present invention also relates to methods for assessing the risk of pregnancy loss or embryo implantation failure, and to methods for monitoring or evaluating the effectiveness of treatments to reduce the risk of pregnancy loss or embryo implantation failure using specific biomarkers. The present invention also relates to the use of these biomarkers in methods for diagnosing reproductive disorders in individuals, as well as methods for treating reproductive disorders. Furthermore, the biomarkers can further be used in methods for selecting patients for treatment to reduce the risk of embryo implantation failure or miscarriage. The present invention also relates to kits for use in any of the methods described herein.

The present application relates to the technical field of animal breeding, and discloses a compound nutritional health supplement for laying hens in the egg production period and a preparation and application thereof, which comprises the following raw materials in mass fractions: motherwort 1200-1400 parts, radix astragali 150-250 parts, radix codonopsis 80-120 parts, betaine hydrochloride 500-700 parts, butyric acid clostridium 50-70 parts, bacillus licheniformis 90-110 parts, vitamin acetate 3-5 parts, coated 25-hydroxy-cholecalciferol 1-2 parts, vitamin E acetate 15-25 parts, and rice husk powder 0-411 parts. The formula can scientifically and comprehensively regulate the digestion and absorption of nutrients, immune function and reproductive system health of laying hens, improve the eggshell quality, egg weight and nutritional quality of egg products, has stable effect and strong universality, greatly reduces the side effects and body burden caused by long-term medication while ensuring the effect, and is more suitable for the concept of healthy breeding; the health level of the body is comprehensively improved, the intestinal flora balance is maintained by probiotics, the immunity and stress resistance of laying hens are overall enhanced, the nutrient utilization rate is improved, and healthy high yield is achieved.

The invention discloses Akkermansia muciniphila and application of a metabolite butyric acid of the Akkermansia muciniphila in preparation of drugs for relieving reproductive disorder of hypothalamus-pituitary-adrenal axis (HPA axis) and hypothalamus-pituitary-gonad axis (HPG axis), and develops a new function of the strain for relieving reproductive injury. The strain inhibits the HPA axis activity and reduces the stress hormone level by secreting butyric acid, so that the HPG axis function is activated, the reproductive system injury of ICR mice caused by high-density crowding stress is remarkably improved, and the sperm density is increased, the reproductive hormone level is increased, and the testis structure is improved. In addition, as a core metabolite of the Akkermansia muciniphila, the butyric acid can independently mediate the regulation and control process. The invention provides a new mechanism of animal population density-dependent reproductive homeostasis mediated by butyric acid, provides a potential micro-ecological intervention strategy for coping with reproductive capacity decline caused by social stress, and provides a new thought and method for treating animal and human reproductive injury.

The invention relates to the technical field of animal feeds, in particular to a mouse feed and a preparation method and application thereof, and the mouse feed comprises curcumin and a basic ration; wherein the curcumin is provided in the form of a drug-loaded pellet; the basic ration is SPF (specific pathogen free) grade rat ration. The feed for the rats contains curcumin, effectively relieves damage of the plateau low-oxygen environment to the reproductive system of the rats, improves sperm motility, reduces the malformation rate, adjusts the reproductive hormone level, and provides an innovative solution for plateau animal reproductive health management.

The invention belongs to the technical field of traditional Chinese medicine pharmacy, and provides a freeze-dried powder pharmaceutical composition for impotence and a preparation method thereof, and the freeze-dried powder pharmaceutical composition is prepared from the following traditional Chinese medicinal materials as raw materials in parts by weight: 5-10 parts of pilose antler, 5-10 parts of hippocampus, 10-20 parts of fructus lycii, 10-20 parts of Chinese yam and 10-20 parts of semen cuscutae. Through the synergistic effect of the pilose antler, the hippocampus, the fructus lycii and other traditional Chinese medicinal materials, the traditional Chinese medicine composition can tonify kidney yang, benefit essence and blood, improve impotence symptoms, strengthen muscles and bones, relieve soreness, weakness and pain of the waist and integrally regulate the male reproductive system and body functions; the freeze-dried powder technology is adopted for drying at low temperature, active ingredients such as pilose antler polypeptide and polysaccharide are reserved to the maximum extent, and oxidation or degradation of the active ingredients is avoided; after moisture is removed, the growth of microorganisms can be inhibited, and the shelf life is prolonged; and the freeze-dried powder has a loose and porous structure, so that the re-dissolving speed is high, and the active ingredients exist in a nearly natural state and are more easily absorbed by gastrointestinal mucosa.

The invention relates to a device (10) for producing an effect on a male reproductive system or a part thereof, and an associated system. An apparatus (10) is disclosed that includes a rigid cup (26) for a penis head, coupling means (28) for coupling the rigid cup to the penis as the penis head is inserted into the cup, sealing means for sealing between the rigid cup and the penis to prevent or impede air from entering the cup when the penis head is inserted, and a push / pull actuator (30) configured to be coupled to the rigid cup and operable to move the cup back and forth reciprocally with the inserted penis head. The vacuum locking effect can lock the penis head with the cup upon push / pull movement. The device may be used to promote massage, erection, extensive climax or stimulate globular cavernous muscles and / or pelvic floor muscles.

Methods and devices to control movement of microorganisms, sperm or viruses within a female reproductive system, including methods and devices for preventing infection or pregnancy. Devices may include a cervical barrier that is configured to allow biological fluids to exit the uterus and cervical canal while preventing the ascension of microorganisms, sperm or viruses into the cervical canal and uterus.

The invention provides a microbial composition with a green in-situ remediation function as well as a preparation method and application thereof, and relates to the technical field of microorganisms. The microbial composition is prepared from the following components in parts by weight: 1 part of a glomus fusiformis inoculant, 0.9 to 1.1 parts of a rhizosporidium endophyllum inoculant and 0.9 to 1.1 parts of a physocheilus mosseae inoculant. The microbial composition provided by the invention can promote the growth and development of plants in micro-plastic polluted soil, promote the growth and development of food chain animals, and reduce the concentration of micro-plastics in plants and animals. The relieving effect of the microbial composition on the toxicity of the microplastics can be transmitted through a soil-plant-food chain, enrichment of the microplastics in herbivores such as snails is reduced, the toxic influence of the microplastics on the digestive system, the antioxidant system and the reproductive system of the animals is relieved, and a multi-nutritional-level ecological protection mechanism is established.

The subject of the application is a dietary supplement containing 2.5 - 7 wt.% indole-3-carbinol, 2 - 6 wt.% epigallocatechin gallate, 30 - 70 wt.% myo-inositol, 6 - 12.5 wt.% N-acetylcysteine, 2.5 - 7 wt.% quercetin, 5 - 8.5 wt.% Omega-3 acid, 5 - 8.5 wt.% alphalipoic acid, 2 - 6 wt.% vitamin C, 1 - 5 wt.% resveratrol, 0.01 - 0.2 wt.% vitamin D3, 0.5 - 3.5 wt.% vitamin E, 0.2 - 15 wt.% alpha-lactalbumin, 0.04 - 20 wt.% curcumin, 0.2 – 15% w / w D-chiroinositol, 0.2- 24% w / w inulin, a probiotic consisting of a mixture of strains of the Lactobacillus, Bifidobacterium and Saccharomyces genera for patients with reproductive system diseases supporting the reduction of estrogen levels and estrogen and progesterone receptors.

This invention discloses a compound moxa stick for warming yang and unblocking obstruction, its preparation method, and its application in improving reproductive system function. It belongs to the field of external preparations of traditional Chinese medicine. Addressing the problems of limited improvement effects of pure moxa sticks, lack of systematic design in compound moxa stick formulations, unclear synergistic effects between components, large fluctuations in conditioning effects, and difficulty in balancing conditioning effects and safety, this invention uses specific weight proportions of Artemisia argyi, Cyperus rotundus, Alpinia galanga, Cinnamomum cassia, Zingiber officinale, Illicium verum, Cinnamomum cassia twig, Spatholobus suberectus, Caesalpinia sappan, Smilax glabra, Euonymus fortunei, Citrus aurantium, Amomum villosum, Citrus reticulata peel, and Atractylodes lancea to prepare a compound moxa stick. The components synergistically enhance each other, and this product is used to prepare a moxibustion intervention product for improving the reproductive function of mammals. It can stably improve female ovarian reserve function and male asthenospermia, simultaneously regulate reproductive-related hormone levels, repair pathological damage to reproductive organs, and improve the quality of reproductive cells.

The invention discloses a traditional Chinese medicine formula with a reproductive system radiation damage protection effect as well as a preparation method and application of the traditional Chinese medicine formula. The traditional Chinese medicine formula comprises the following components in parts by mass: 15-30 parts of Chinese yam, 6-15 parts of dogwood, 10-30 parts of astragalus membranaceus, 10-30 parts of prepared rehmannia root, 10-15 parts of spina date seed, 6-15 parts of fructus psoraleae, 5-15 parts of fructus lycii and 3-9 parts of rhodiola rosea. In the traditional Chinese medicine formula provided by the invention, all the components have a synergistic effect, so that the injury of ionizing radiation to a reproductive system can be effectively relieved, the pathological change of testis tissues is remarkably improved, sperm quality parameters are improved, the apoptosis process of testis cells is inhibited, the injury caused by oxidative stress is repaired, and the DNA injury degree is reduced; therefore, the technical defects of high toxicity, high cost, insufficient protective effect on the reproductive system and the like of the existing radiation protective agent are overcome.

The invention discloses a method for analyzing the pharmacodynamic material basis and action mechanism of a laying hen Bao traditional Chinese medicine. The method specifically comprises the following steps: (1) identifying chemical components in the laying hen Bao by UHPLC-HRMS (Ultra High Performance Liquid Chromatography-High Resolution Mass Spectrometry); (2) screening a core target spot of the laying hen for treating poultry reproductive system diseases; (3) obtaining the drug effect material basis of the laying hen feed; and (4) constructing a'laying hen bao-effective component-core target group-signal channel 'regulation network. According to the method, a traditional Chinese medicine component chemical analysis technology and a network pharmacology method are combined, a systematic and multi-dimensional analysis tool is provided for research on the traditional Chinese medicine effect material basis of the traditional Chinese medicine compound laying hen Bao, the chemical components in the traditional Chinese medicine compound laying hen Bao can be effectively recognized, the medicine effect material basis can be screened, target spots and channels related to the medicine effect can be recognized, and the method is suitable for popularization and application. A new thought is provided for revealing the scientific connotation of'multi-component, multi-target and multi-channel 'of the traditional Chinese medicine compound laying hen bao.