417 results about "Thioketone" patented technology

A pharmaceutical composition comprising a co-crystal of an API and a co-crystal former; wherein the API has at least one functional group selected from ether, thioether, alcohol, thiol, aldehyde, ketone, thioketone, nitrate ester, phosphate ester, thiophosphate ester, ester, thioester, sulfate ester, carboxylic acid, phosphonic acid, phosphinic acid, sulfonic acid, amide, primary amine, secondary amine, ammonia, tertiary amine, sp2 amine, thiocyanate, cyanamide, oxime, nitrile diazo, organohalide, nitro, s-heterocyclic ring, thiophene, n-heterocyclic ring, pyrrole, o-heterocyclic ring, furan, epoxide, peroxide, hydroxamic acid, imidazole, pyridine and the co-crystal former has at least one functional group selected from amine, amide, pyridine, imidazole, indole, pyrrolidine, carbonyl, carboxyl, hydroxyl, phenol, sulfone, sulfonyl, mercapto and methyl thio, such that the API and co-crystal former are capable of co-crystallizing from a solution phase under crystallization conditions.

The present invention relates to an antimicrobial composition comprising an isothiazolinone, such as 1,2-benzisothiazolin-3-one, and a zinc compound selected from zinc salts, zinc oxides, zinc hydroxides or combinations thereof. Useful zinc salts include for example, oxides, sulfates, chlorides, and combinations thereof. In use, the zinc from the zinc compound enhances the antimicrobial activity to the isothiazolin-containing composition. This enhancement permits achieving the desired antimicrobial activity at a lower usage rate than is achieved using the isothiazolinone in the absence of the zinc compound. The antimicrobial composition can also contain co-biocides, such as pyrithiones, including zinc pyrithione or copper pyrithione.

An antifouling coating composition substantially not containing cuprous oxide and organotins, characterized by comprising (A) a metal-containing copolymer obtained by copolymerization of a polymerizable unsaturated monomer (a1) containing a metal and an unsaturated monomer (a2) capable of radical polymerization containing no metals; (B) 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one; and (C) a metal pyrithione compound. There are provided an antifouling coating composition, antifouling coating film and, covered with the antifouling coating film, marine vessel, underwater structure and fishing gear or fishing net, which can reduce burdens on the environment, exhibiting excellent antifouling performance, and which excel in not only uniform wasting of coating film but also capability of maintaining antifouling performance of coating film for a prolonged period of time.

The invention discloses an antimicrobial and antidandruff composition and application thereof. The composition comprises a pyrithione polyvalent metal salt and an alkoxy aromatic amidine compound, and preferably comprises zinc pyridine thione and hexamidine isethionate, wherein the weight ratio of the zinc pyridine thione to the hexamidine isethionate in the composition is 1:20-10000:1. The composition can be applied in washing-off systems such as liquid shampoos, hair conditioners, facial cleansers, dermatophytosis removal products or shower gel and the like which have the effects of sterilization and antibiosis. The antimicrobial and antidandruff composition can provide the high-efficiency effect of dandruff removal and sterilization, overcome the defect that the effects of dandruff removal, sterilization and itching relieving are not obvious due to the single use of any one component in the composition under the same condition, and play an excellent role in the dandruff removal, sterilization and itching relieving; and the zinc pyridine thione and the hexamidine isethionate have the synergic effect on the using effect, and the composition is used in products under the same using condition and using amount to reduce the amount used when only single component in the composition is used effectively, so the effects of the dandruff removal and itching relieving can be achieved.

Compounds of Formula 1

• • where the variables have the meaning defined in the specification are agonists of alpha₂ adrenergic receptors. Several compounds of the disclosure are specific or selective to alpha_2B and/or alpha_2C adrenergic receptors in preference over alpha_2A adrenergic receptors. Additionally some of the claimed compounds have no or only minimal cardivascular and/or sedatory activity. The compounds of Formula 1 are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha₂ adrenergic receptors. Compounds of Formula 1 which have no significant cardiovascular and/or sedatory activity are useful for treating pain and other conditions with minimal side effects.

The invention provides a method for preparing taurine and substituted taurine, which takes 1, 3-thiazolidine-2-thioketone and derivants thereof as raw material to prepare taurine and substituted taurine. The method has the advantages that the raw material can be obtained easily, the operation is convenient, the purification through desalination is not needed, and the method is particularly suitable for large-scale industrialized production and can be utilized to prepare optically active substituted taurine. The obtained compound can be used as nutritive matters, medicines, enzyme inhibitors, antimicrobials, surface active agents, plant growth regulators, raw material for preparing sulfono-peptides, etc.

This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether.

The invention relates to the technical field of electrolytic copper foils, in particular to an additive for electrolytic copper foil, an ultra-low peak HVLP copper foil and a preparation method of theultra-low peak HVLP copper foil. The additive comprises at least four of an acid copper throwing agent, a terahydrozoline thioketone, a monosodium salt, a 3,3'-dithiobis-1-propanesulfonicacidisodiumsalt, a collagen and a cowhide polypeptide as well as chloridion. The additive for the electrolytic copper foil, the ultra-low peak HVLP copper foil and the preparation method of the ultra-low peak HVLP copper foil have the advantages of low roughness, excellent mechanical property and good oxidation resistance.

The invention discloses a method for preparing quinazoline-2-thioketone. The method comprises the steps of: under the catalysis of silicoamino rate-earth compound [(Me3Si)2N]3Ln(mu-Cl)Li(THF)3s erving as a catalyst; and preparing the quinazoline-2-thioketone by addition reaction of catalytic o-amino ethyl cinnamate and isothiocyanate, wherein Ln represents a triad rate-earth metal ion and is one of lanthanum, neodymium, samarium or ytterbium; (Me3Si)2N represents trimethyl silicoamino; mu- represents a bridged bond; THF represents tetrahydrofuran; the chemical structural formula of the o-amino ethyl cinnamate and isothiocyanate is shown in the specification; and the general formula of the chemical structure of the isothiocyanate is RNCS. In the method, the catalyst is good in chemical selectivity, high in reactivity, mild in reaction condition and in no need of a solvent, and the yield of a target product is high.

The invention relates to a preparation method of a prothioconazole intermediate. The preparation method comprises the following steps: dissolving [1-(2-chlorophenyl)-2-(1-chlorocyclopropyl)-2-hydroxy]-propyl hydrazine into methyl benzene; dropwise adding a formaldehyde aqueous solution or a polyformaldehyde aqueous solution under 30 to 35 DEG C; then adding in thiocyanate after completion of dropwise adding; then dropwise adding hydrochloric acid or sulfuric acid aqueous solution; keeping warm and reacting for 50 to 70 minutes after completion of dropwise adding; directly using a reaction solution for follow-up reaction or filtering the reaction solution after cooling; thus obtaining the prothioconazole intermediate 2-(1-chloro-cyclopropyl-1-yl)-1-(2-chlorophenyl)-2-hydroxy-3-(1,2,4-triazolidine-5-thioketone-1-yl)-propane. Through optimization on a whole route, for example, reaction temperature, reagents, a feeding procedure and the like, of the preparation method, an after-treatment method is simple, three wastes such as waste gas, waste water and waste residues are few, the reaction time is shortened, the purity and the yield of a product are higher, and the preparation method is suitable for industrial production.

The invention discloses a synthetic method of a pyronine derivative dye. The synthetic method comprises the following steps: with pyronine as a raw material, producing carbine serving as an intermediate under the action of potassium tert-butoxide, carrying out reaction on carbine and sulfur or oxygen to produce pyronine thione or ketone, and then carrying out reaction on pyronine thione and amine or halohydrocarbon to produce the pyronine derivative dye. The synthetic method is safe and simple in operation, short in reaction time and good in yield and purity of the pyronine derivative dye.

The invention discloses application of a 1,3,4-oxadiazole-2-thioketone flotation collector. According to the application, a 1,3,4-oxadiazole-2-thioketone compound is adopted as a mineral flotation collector for application to flotation recovery of valuable metals in ore which contains a copper, silver or gold mineral. Compared with a common flotation collector in the prior art, the 1,3,4-oxadiazole-2-thioketone flotation collector has the advantage that enrichment and recovery of the copper, silver or gold mineral can be effectively improved.