80 results about "Thioketone" patented technology

The invention discloses a preparation method of a 3-micron ultrathin lithium battery copper foil. The preparation method comprises the following steps: preparing a copper sulfate electrolyte; a wetting agent, a brightening agent and a high resistance agent are added into the copper sulfate electrolyte, the high resistance agent is at least one of thiazolidinethione, polyethyleneimine, 2-mercaptobenzimidazole and ethylene thiourea, and a mixed additive is formed; polishing and grinding a cathode roller by adopting a flying wing wheel, and carrying out electrolytic treatment on the mixed additive through the polished and ground cathode roller to obtain a first-stage copper foil; and the first-stage copper foil is placed in a nitrogen furnace to be subjected to annealing treatment, and the 3-micron ultrathin lithium battery copper foil is obtained. The invention aims to solve the technical problems that in the prior art, edge tearing, foil breaking, warping, dark appearance oxidation and the like are prone to occurring in the production process of the ultrathin copper foil, the tensile strength and the ductility are difficult to consider at the same time, and stable mass production of the 3-micron copper foil is still difficult.

The present disclosure is directed to a preservative composition comprising a linear polyetheramine having a molecular weight greater than 118 Daltons (Da) and at least one isothiazolinone, whereby this preservative composition may further comprise a pyrithione salt and / or a metal salt. Also disclosed is an aqueous industrial material comprising the preservative composition as well as a method for enhancing in-contaniner preservative performance of an aqueous industrial material using the preservative composition.

The invention discloses a phenolic resin material as well as a preparation method and application thereof in 3D printing, and relates to the technical field of high polymer materials. When the phenolic resin material is prepared, hydroxylated carbon nanotubes react with isocyanate propyl triethoxy silane to prepare pre-modified carbon nanotubes, and then the pre-modified carbon nanotubes react with 2-chloroethyl triethoxy silane to prepare modified carbon nanotubes; the preparation method comprises the following steps: reacting vanillin with 5-amino-1, 2-dihydro-2-methyl-3H-1, 2, 4-triazole-3-thioketone and 9, 10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide in sequence, so as to obtain pre-modified vanillin; reacting the pre-modified vanillin with divinyl disulfide to obtain modified vanillin; the modified vanillin, phenol and formaldehyde react to prepare modified phenolic resin, and then the modified phenolic resin reacts with the modified carbon nanotubes to prepare the phenolic resin material. The phenolic resin material prepared by the invention has good flame retardance, heat resistance, aging resistance, self-repairing property and mechanical property.

The present invention discloses a near-infrared photosensitizer-based nanotherapeutic agent, its preparation method, and application. The near-infrared photosensitizer-based nanotherapeutic agent comprises a protein and a near-infrared prodrug bound to a hydrophobic cavity of the protein. The near-infrared prodrug comprises a near-infrared photosensitizer connected to a cupric sulfide bond and a chemotherapy drug bound to the near-infrared photosensitizer connected to the cupric sulfide bond via a thioketone bond. The near-infrared photosensitizer-based nanotherapeutic agent provided by the present invention significantly improves the solubility and bioavailability of the chemotherapy drug and the near-infrared photosensitizer, achieves tumor targeting and selectivity, thereby increasing the drug accumulation at the tumor site, improving the therapeutic effect, and reducing toxic side effects. This solves the problems of existing near-infrared fluorescent dyes, which have limited targeting and selectivity and low therapeutic effect.

The Invention relates to a method Method for making a ruthenium catalyst comprising the steps of - Providing an aromatic dithiol substituted on adjacent aromatic carbon atoms with thiol groups, wherein in a first step an aromatic compound substituted with two leaving groups on adjacent aromatic carbon atoms are reacted with alkali trithiocarbonate to obtain an aromatic benzodithiole-thione, which in a subsequent step is reacted / hydrolysed with a base; - providing a zinc dithiolate compound by reacting the aromatic dithiol with a zinc carboxylate in an organic solvent; Reacting the zinc dithiolate compound with a ruthenium compound wherein X1 and X2 are, independently of each other, are anionic ligands and are the same or different; L and L2 are, independently of each other, neutral electron donor ligands and are the same or different; Ar is an aromatic group which may be substituted and that can be bridged with L, if L is an alkoxy group; - Obtaining a ruthenium catalyst of formula 4 or 4a, wherein R1 to R4 are, independently of each other, are selected from hydrogen, halogen, alkyl, aryl, or R.1 with R3, R3 with R4 or R2 with R4 are forming together an aliphatic or aromatic ring.

The present application relates to the technical field of copper-clad plate preparation, and particularly relates to a halogen-free flame-retardant BT resin-based copper-clad plate and a preparation method thereof. The present application adds 3,4-dihydroxybenzaldehyde, triethylamine, 7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-thione and ethyl acetate to prepare an antibacterial monomer. Then, the Zn-MOF material, the antibacterial monomer and 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide are used to prepare a flame retardant. Finally, the cyanate ester resin, the bismaleimide resin, the epoxy resin, the flame retardant, the solvent, the filler and the curing agent are added to prepare a resin glue solution. The glass fiber cloth is immersed in the resin glue solution, and then high-temperature curing, copper foil lamination and laminated molding are performed to prepare a finished product. The finished product prepared by the present application has good flame retardance and antibacterial property, and therefore has a wide application prospect in the technical field of copper-clad plate preparation.

The invention discloses a composition containing a turmeric analogue and application of the composition in an insecticide. The structural formula of the turmeric analogue is (E)-3-((1H-indole-3-yl) methylene)-5-((E)-4-mercaptobenzylidene)-1-methylpiperidine-4-thioketone. The turmeric analogue is synthesized through multi-step reaction, including aldehyde acylation, cyclization, thiolation reaction and condensation reaction. Insecticidal experiments show that the composition has good inhibitory activity on beet armyworms and can be used as a potential pesticide for preventing and treating beet armyworms.

The application discloses a preparation method of metal and alloy nanoclusters, which comprises the following steps: S1, weighing a certain amount of N-heterocyclic-2-thione ligand and metal salt, dissolving in a proper amount of solvent, fully stirring, and uniformly mixing to obtain a corresponding metal complex; S2, continuously stirring, observing color change, and continuously reacting for a period of time to obtain a crude product; and S3, slowly evaporating in the dark to obtain a single crystal of the metal and alloy nanoclusters; and the application provides a simple, high-yield and good-crystallinity method for preparing metal and alloy nanoclusters by using N-heterocyclic-2-thione organic ligand.

The invention discloses a sealant with bacteriostatic and mildew-proof functions for a metal bottle cap and a preparation method of the sealant, and belongs to the technical field of sealant preparation. The sealant provided by the invention is prepared from the following raw material components in percentage by mass: 40.0 to 55.0 percent of an auxiliary agent A, 0.5 to 3.0 percent of an auxiliary agent B, 2.0 to 4.0 percent of zinc stearate, 1.0 to 3.0 percent of titanium dioxide, 1.0 to 5.0 percent of ground calcium carbonate, 0.5 to 2.5 percent of an anti-blocking agent and 39.0 to 55.0 percent of polyvinyl chloride resin, the auxiliary agent A is prepared from at least two of dioctyl terephthalate, epoxidized soybean oil, trimellitic anhydride and cyclohexane 1, 2-diisononyl diformate; the auxiliary agent B is obtained by mixing and grinding zinc oxide, metal silver, zirconium phosphate, zinc pyrithione and coconut oil fatty acid diacetamide. According to the invention, the sealant is prepared by compounding multi-component food-grade antibacterial mildew-proof active components, so that the prepared sealant is ensured to reach the first-grade standard of ASTM G21-15 Determination of Antifungal Factor of Synthetic High Polymer Materials, meanwhile, the risk that the sealant is mildewed when being used in canned food is reduced, and the quality of the product is improved.

The present disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in the treatment of infectious diseases, viral infections, and cancer, wherein the base of the nucleotide or nucleoside contains at least one thiol, thione, or thioether.

This invention discloses a photoactivated nanoparticle-based drug delivery material for immunoadjuvants, its preparation method, and its applications. The drug delivery material is constructed from photosensitizer monomers, crosslinking monomers, and immunoadjuvant prodrug monomers within a confined space of a nanoemulsion via a copper-free click polymerization reaction to form crosslinked polymer nanoparticles. The nanoparticle size is controllable, and the composition is precisely defined. Under physiological conditions, the drug delivery material exhibits good colloidal stability and high drug loading. Upon near-infrared light irradiation, the generated ROS can cleave the thioketone bonds, causing the nanoparticles to depolymerize and achieving photo-triggered, controllable release of the immunoadjuvant. Under photodynamic action, this drug delivery material efficiently generates reactive oxygen species to induce immunogenic cell death in tumor cells. Simultaneously, the released immunoadjuvant activates the TLR7 / 8 pathway, promotes dendritic cell maturation, and enhances the systemic anti-tumor immune response, thereby inhibiting the growth of tumors in situ and at distant sites, and reducing the risk of metastasis and recurrence.

The invention discloses a light-transmitting diaphragm, a preparation method thereof and a display device, which are used for simultaneously realizing antibacterial, antiviral and anti-fingerprint effects. The embodiment of the invention provides a light-transmitting membrane. The light-transmitting membrane comprises a substrate and a functional layer located on one side of the substrate. The functional layer comprises an anti-fingerprint layer and an antibacterial and antiviral layer which are arranged in a crossed manner in the direction parallel to the plane where the substrate is located; the antibacterial and antiviral layer comprises a polysiloxane group and an antibacterial and antiviral molecular group grafted to the polysiloxane group; the antibacterial and antiviral molecular group comprises a group formed by grafting thiabendazole and / or zinc pyrithione on polysiloxane; the anti-fingerprint layer comprises a polysiloxane group and an anti-fingerprint molecular group grafted to the polysiloxane group; the anti-fingerprint molecular group comprises a group formed by cross-linking polymerization reaction of a perfluoropolyether compound.

A 1-hydroxyalkyl-5-mercapto-1,2,4-triazole-3-carboxylic acid compound of formula (1): in which R1, R2, R3 and R4 are each independently selected from the group consisting of hydrogen, unsubstituted and substituted C1-C18 alkyl, unsubstituted and substituted C1-C18 alkenyl, unsubstituted and substituted C3-C18 cycloalkyl, unsubstituted and substituted C6-C14 aryl, unsubstituted and substituted C1-C13 heteroaryl, unsubstituted and substituted C7-C18 aralkyl, unsubstituted and substituted C8-C18 arylalkenyl, and unsubstituted and substituted C7-C18 aryloxyalkyl, and n is 1, 2, 3 or 4. A preparation method for the 1-hydroxyalkyl-5-mercapto-1,2,4-triazole-3-carboxylic acid compound is also provided, in which a hydroxyalkylhydrazine compound is used as a starting material, and undergoes a condensation reaction, an addition-cyclization reaction and dehydrogenation in sequence to obtain the 1-hydroxyalkyl-5-mercapto-1,2,4-triazole-3-carboxylic acid compound. An use of such compound in the preparation of a 2-hydroxyalkyl-1,2,4-triazole-3-thione compound is also provided.

The invention discloses low-copper environment-friendly self-polishing antifouling paint and a preparation method thereof. The antifouling paint is prepared from modified zinc acrylate resin, rosin, modified cuprous oxide, zinc pyrithione, zinc oxide, a reinforcing blending agent, a multifunctional additive, organic silicon resin, a solvent, barium sulfate, calcium carbonate, a dispersing agent, a flatting agent and chlorinated paraffin. The low-copper environment-friendly self-polishing antifouling paint disclosed by the invention has excellent antifouling efficiency, good adhesive force and stability and excellent mechanical durability and chemical resistance; the antifouling paint has wide application prospects in the fields of ocean engineering, port facilities, aquaculture net cages and the like, the maintenance cost can be remarkably reduced, and the service life of equipment is prolonged.

The invention relates to the technical field of lead-containing mineral wastewater treatment, in particular to a quinoline thioketone compound as well as a preparation method and application thereof. The invention provides a preparation method of a quinoline thioketone compound, and the quinoline thioketone compound prepared by the preparation method has good water phase response characteristics, and has ultrahigh selectivity and strong chelating precipitation capacity to Pb < 2 + > in a wide pH range.

The application belongs to the field of pharmaceutical chemical industry and particularly relates to a preparation method of enzalutamide. In the application, N-BOC-2-aminoisobutyramide is used as a starting material to form a ring with phenyl chlorothioformate to obtain 5,5-dimethyl-1-tert-butoxycarbonyl-2-thione imidazole-4-ketone, the obtained product is further subjected to nucleophilic substitution with 2-trifluoromethyl-4-bromobenzonitrile, is deprotected, and is subjected to nucleophilic substitution with 2-fluoro-4-bromobenzamide to obtain enzalutamide. The method uses N-BOC-2-aminoisobutyramide as a starting material, does not produce disubstituted impurities, has higher conversion rate, can obtain a product with high yield, and is more suitable for industrial amplification.

The invention discloses a rubber composite material with marine antifouling property as well as a preparation method and application thereof, and relates to the technical field of marine fouling organism decay protection materials. The rubber composite material with the marine antifouling property comprises the following components which are blended and vulcanized: rubber, a filler, an antifouling agent, a plasticizer, an activating agent, a scorch retarder, an anti-aging agent, an accelerant and a vulcanizing agent, the antifouling agent comprises a copolymer modified by zwitter-ions and at least one of sodium benzoate, tannic acid, 6-gingerol, capsaicin, sulfobetaine, carboxylic acid betaine, phosphorylcholine, isothiazolinone and zinc pyrithione optionally selected from the group consisting of sodium benzoate, tannic acid, 6-gingerol, capsaicin, sulfobetaine, carboxylic acid betaine, phosphorylcholine, isothiazolinone and zinc pyrithione. The invention solves the three core problems of poor compatibility of an antifouling agent and a rubber matrix, short antifouling period caused by easy loss of the antifouling agent, and difficulty in balancing the antifouling property and mechanical property in the existing marine antifouling rubber material.

The invention is applicable to the technical field of chemical materials, and provides a method for regulating and controlling luminescence of Au nanoclusters by solvent-induced ligand isomerization, which comprises the following steps: firstly, synthesizing the gold nanoclusters with different surface isomer proportions by regulating the pH value of a reaction system; au (I)-thioketone and Au (I)-mercaptan isomer are induced to be reversibly converted by utilizing the interaction of solvent molecules and a cluster surface ligand structure, and proton coupling electron transfer kinetics is cooperatively regulated, so that the precise regulation of the luminescence property of the gold nanocluster is realized. According to the present invention, the wide band and the continuous reversible adjustment of the light-emitting wavelength in the range of 495-800 nm can be achieved under the mild condition, the light-emitting quantum yield can be significantly improved, and the method has advantages of simple operation, clear mechanism, greenness and universality, and has application prospects in the fields of biological imaging, optical sensing, light-emitting devices and the like.

This disclosure relates to nucleotide and nucleoside therapeutic compositions and their use in treating infectious diseases, viral infections and cancer, wherein the bases of said nucleotide or nucleoside contain at least one thiol, thion, or thioether.

The application discloses a rare earth compound flocculant and a preparation method and application thereof, and comprises a rare earth compound of gluconic acid, a rare earth compound of pyrithione and water, wherein the content of the rare earth compound of gluconic acid is 5-15 wt%, the rare earth compound of gluconic acid is prepared by reacting sodium gluconate and a first rare earth chloride salt in water; the content of the rare earth compound of pyrithione is 0.4-0.6 wt%, and the rare earth compound of pyrithione is prepared by reacting sodium pyrithione and a second rare earth chloride salt in water. The rare earth ions in the application have positive electricity, show extremely strong coordination ability and high coordination number. Meanwhile, the surface of Phaeodactylum tricornutum is negatively charged; therefore, when the rare earth ions contact with the Phaeodactylum tricornutum, the two can rapidly interact in electricity, cause the Phaeodactylum tricornutum to rapidly aggregate and form a mass, and then gradually precipitate.

This invention relates to a continuous flow method for preparing taurine, comprising the following steps: S1, using an alkaline solution of ethanolamine and a carbon disulfide solution as raw materials, simultaneously introducing them into a pressurized first continuous flow reactor to react and obtain a first reaction solution; S2, cooling, filtering, washing, and extracting the first reaction solution to obtain thiazolium-2-thione; S3, dissolving thiazolium-2-thione in an organic acid to obtain a thiazolium-2-thione solution; using the thiazolium-2-thione solution and hydrogen peroxide solution as raw materials, simultaneously introducing them into a second continuous flow reactor to react and obtain a second reaction solution, which is then post-treated to obtain taurine. This invention provides an ideal synthetic route, and through continuous flow reaction, the reaction time is short, resulting in high yield and purity of taurine, effectively reducing costs; the process is simple to operate, safe, and efficient, facilitating large-scale industrial production.

The invention relates to the field of organic synthesis methodology, in particular to a quinazoline dihydroimidazole thione derivative and a preparation method and application thereof.The quinazoline dihydroimidazole thione derivative is prepared by reacting aryl glyoxal, o-aminobenzene amine, aryl isothiocyanate and an additive at a certain temperature under the closed condition and the solvent condition. The method has the characteristics that the catalyst is cheap and easy to obtain, the raw materials are easy to obtain, the operation is simple, the reaction time is short, the yield is relatively high, the functional group compatibility of the substrate is good, a series of quinazoline and dihydroimidazole thione derivatives can be synthesized, and the method has a good potential application value.

Examples of a biocide composition include an activated halogen compound selected from the group consisting of 2,2-dibromo-3-nitrlopropionamide; 2-bromo-2-nitropropane-1,3-diol; and 1,2-dibromo-2,4-dicyanobutane; benzisothiazolin-3-one; a pyridine-N-oxide selected from the group consisting of zinc pyrithione and sodium pyrithione; and a carbamate derivative selected from the group consisting of 3-iodo-2-propynyl butyl carbamate; zinc bis(dimethyldithiocarbamate); and bis(dimethyl carbamoyl) disulfide.

The present invention relates to ibuprofen triazole thiol derivatives or ibuprofen triazole thione derivatives shown in structural formula I or II, their preparation methods, pharmaceutical compositions, and their use in the preparation of novel coronavirus 3CL protease inhibitors. Ibuprofen triazole thione is a tautomer of ibuprofen triazole thiol derivatives. Wherein R is selected from: hydrogen, deuterium, C1-C2 alkyl, C3-C7 straight chain or C3-C7 branched alkyl; Z is selected from: hydrogen, 4-fluoro, 4-hydroxy, 2-(2,6-dichloroanilino), 4-isobutyl, 3-fluoro-4-phenyl, 3-phenoxy, 3-benzoyl, 4-(2-methylallylamino) or 4-(2-oxocyclopentylmethyl); Y 1 、Y 2 and Y 4 is selected from the group consisting of: hydrogen, deuterium, C1-C2 alkyl, nitro, amino, fluorine, chlorine, bromine, iodine, hydroxyl, methoxy or ethoxy; Y 3 is selected from the group consisting of: hydrogen, deuterium, C1-C2 alkyl, hydroxy, ethoxy, nitro, amino, methylamino, dimethylamino, acetylamino, fluorine, chlorine, bromine or iodine; Y 5 is selected from the group consisting of: hydrogen, deuterium, C1-C2 alkyl, nitro, amino, fluorine, chlorine, bromine or iodine.

The invention provides an electrolyte for preparing a copper foil with high tensile strength, the copper foil and a preparation method of the copper foil, the electrolyte comprises a main electrolyte and an additive, the main electrolyte comprises copper sulfate, sulfuric acid and chloride ions, the additive is prepared from industrial collagen, sodium dimethylformamide propane sulfonate, thiazolidinethione, fatty amine polyoxyethylene ether and hydroxypropyl methyl cellulose. According to the system, an industrial collagen and thiazolidinethione synergistic film forming mechanism is adopted, abnormal growth of copper grains is effectively inhibited, and the toughness and tensile strength of the material are enhanced; sodium dimethylformamide propane sulfonate is used as an efficient brightener to optimize a deposition microstructure and reduce grain boundary defects; hydroxypropyl methyl cellulose and fatty amine polyoxyethylene ether cooperatively regulate and control an electrolyte flow field, concentration polarization is reduced, and deposition uniformity is ensured; meanwhile, chloride ions and the thioketone additive form a stable coordination system, so that the deposition compactness is improved, and stress concentration is avoided.

The present invention is directed to a personal cleansing composition comprising from about 6% to about 50% of one or more sulfate free surfactants; from about 0.5% to 20% of lauramidopropyl betaine; from about 0.1% to about 10% of zinc pyrithione; from about 0.05% to about 3% of a cationic polymer; from about 0.05% to 10% of a stabilizing polymer from about 0.1% to about 2% of a preservative and having a pH of from about 5 to about 7.

The invention belongs to the technical field of sponges, and particularly relates to an anti-mite, mildew-proof and antibacterial sponge which comprises the following components in parts by weight: 100 parts of polyether polyol; 45.1 to 51.0 parts of toluene diisocynate; 0.7 to 1.0 part of soft foam silicone oil; 0.12 to 0.28 part of an amine catalyst; 0.1 to 0.3 part of a tin catalyst; 2-3 parts of water; 0.5 to 0.9 part of a mildew-proof anti-mite antibacterial agent; the mildew-proof anti-mite antibacterial agent is a mixture of zinc pyrithione, permethrin and benzyl alcohol. Compared with the prior art, the sponge material with excellent performance is designed, the polyether polyol, the polymer polyol and the toluene diisocynate are used as main forming components of the sponge material, and the zinc pyrithione, the permethrin and the benzyl alcohol antibacterial and anti-mite agent are matched for use, so that the anti-mite, mildew-proof and antibacterial effects can be achieved; the sponge material prepared by the invention is comfortable and soft, has good elasticity, and also has relatively strong antibacterial, anti-mite and mildew-proof effects.

The invention belongs to the technical field of biological medicines, and particularly relates to a nanoparticle TPRL as well as a preparation method and application thereof. The nano-particle TPRL provided by the invention is a nano-particle formed by wrapping lycium barbarum polysaccharide and resveratrol with thioketone modified pulmonary surface activity bionic liposome, and in-vitro experiments prove that the nano-particle TPRL can effectively inhibit the AECII cell fibrosis process induced by silicon dioxide. Animal experiments show that the nanoparticle TPRL can significantly improve lung tissue structure damage and abnormal collagen deposition caused by SiO2 exposure, and relieve the pathological progress of silicosis.

The invention belongs to the technical field of organic synthesis, and particularly relates to a thiazolopyrimidine compound as well as a preparation method and application thereof. The thiazolopyrimidine compound is efficiently prepared at room temperature and in an air atmosphere by taking pyrimidinethione and alpha-bromocinnamyl aldehyde as raw materials under the condition of no photocatalyst or additive. Compared with a previously reported preparation method, the method has the advantages of being green, environmentally friendly, safe, efficient and energy-saving, the substrate application range is wide, the compatibility of product functional groups is good, raw materials are easy to obtain, transition metal, a photocatalyst and an external oxidizing agent are not needed, and the medical intermediates and the medical molecules can be simply, conveniently and efficiently synthesized through the method.

The invention provides a preparation method of 5, 5-dimethyl isoxazolidine-3-thioketone and an intermediate thereof, and relates to the technical field of chemical synthesis. The preparation method comprises the following steps: mixing hydroxylamine hydrochloride, isopentenal, sulfide and a first alkali substance, and carrying out a reaction, so as to obtain the 5, 5-dimethyl isoxazolidine-3-thioketone. The hydroxylamine hydrochloride, the isopentenal, the sulfide and the first alkali substance directly react, and a simple and low-cost preparation route is constructed. In the process, a tedious halogenation step is omitted, highly toxic, stink and high-pollution dangerous reagents are completely abandoned, and emission of ammonia-nitrogen wastewater and stink gas is eliminated from the source. The system is mild and stable, and high-efficiency output of high-quality products is realized while extremely high safety and environmental friendliness are ensured.