40 results about "Thioketone" patented technology

The invention discloses a preparation method of a 3-micron ultrathin lithium battery copper foil. The preparation method comprises the following steps: preparing a copper sulfate electrolyte; a wetting agent, a brightening agent and a high resistance agent are added into the copper sulfate electrolyte, the high resistance agent is at least one of thiazolidinethione, polyethyleneimine, 2-mercaptobenzimidazole and ethylene thiourea, and a mixed additive is formed; polishing and grinding a cathode roller by adopting a flying wing wheel, and carrying out electrolytic treatment on the mixed additive through the polished and ground cathode roller to obtain a first-stage copper foil; and the first-stage copper foil is placed in a nitrogen furnace to be subjected to annealing treatment, and the 3-micron ultrathin lithium battery copper foil is obtained. The invention aims to solve the technical problems that in the prior art, edge tearing, foil breaking, warping, dark appearance oxidation and the like are prone to occurring in the production process of the ultrathin copper foil, the tensile strength and the ductility are difficult to consider at the same time, and stable mass production of the 3-micron copper foil is still difficult.

The invention discloses a phenolic resin material as well as a preparation method and application thereof in 3D printing, and relates to the technical field of high polymer materials. When the phenolic resin material is prepared, hydroxylated carbon nanotubes react with isocyanate propyl triethoxy silane to prepare pre-modified carbon nanotubes, and then the pre-modified carbon nanotubes react with 2-chloroethyl triethoxy silane to prepare modified carbon nanotubes; the preparation method comprises the following steps: reacting vanillin with 5-amino-1, 2-dihydro-2-methyl-3H-1, 2, 4-triazole-3-thioketone and 9, 10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide in sequence, so as to obtain pre-modified vanillin; reacting the pre-modified vanillin with divinyl disulfide to obtain modified vanillin; the modified vanillin, phenol and formaldehyde react to prepare modified phenolic resin, and then the modified phenolic resin reacts with the modified carbon nanotubes to prepare the phenolic resin material. The phenolic resin material prepared by the invention has good flame retardance, heat resistance, aging resistance, self-repairing property and mechanical property.

The Invention relates to a method Method for making a ruthenium catalyst comprising the steps of - Providing an aromatic dithiol substituted on adjacent aromatic carbon atoms with thiol groups, wherein in a first step an aromatic compound substituted with two leaving groups on adjacent aromatic carbon atoms are reacted with alkali trithiocarbonate to obtain an aromatic benzodithiole-thione, which in a subsequent step is reacted / hydrolysed with a base; - providing a zinc dithiolate compound by reacting the aromatic dithiol with a zinc carboxylate in an organic solvent; Reacting the zinc dithiolate compound with a ruthenium compound wherein X1 and X2 are, independently of each other, are anionic ligands and are the same or different; L and L2 are, independently of each other, neutral electron donor ligands and are the same or different; Ar is an aromatic group which may be substituted and that can be bridged with L, if L is an alkoxy group; - Obtaining a ruthenium catalyst of formula 4 or 4a, wherein R1 to R4 are, independently of each other, are selected from hydrogen, halogen, alkyl, aryl, or R.1 with R3, R3 with R4 or R2 with R4 are forming together an aliphatic or aromatic ring.

The application discloses a preparation method of metal and alloy nanoclusters, which comprises the following steps: S1, weighing a certain amount of N-heterocyclic-2-thione ligand and metal salt, dissolving in a proper amount of solvent, fully stirring, and uniformly mixing to obtain a corresponding metal complex; S2, continuously stirring, observing color change, and continuously reacting for a period of time to obtain a crude product; and S3, slowly evaporating in the dark to obtain a single crystal of the metal and alloy nanoclusters; and the application provides a simple, high-yield and good-crystallinity method for preparing metal and alloy nanoclusters by using N-heterocyclic-2-thione organic ligand.

The invention discloses a sealant with bacteriostatic and mildew-proof functions for a metal bottle cap and a preparation method of the sealant, and belongs to the technical field of sealant preparation. The sealant provided by the invention is prepared from the following raw material components in percentage by mass: 40.0 to 55.0 percent of an auxiliary agent A, 0.5 to 3.0 percent of an auxiliary agent B, 2.0 to 4.0 percent of zinc stearate, 1.0 to 3.0 percent of titanium dioxide, 1.0 to 5.0 percent of ground calcium carbonate, 0.5 to 2.5 percent of an anti-blocking agent and 39.0 to 55.0 percent of polyvinyl chloride resin, the auxiliary agent A is prepared from at least two of dioctyl terephthalate, epoxidized soybean oil, trimellitic anhydride and cyclohexane 1, 2-diisononyl diformate; the auxiliary agent B is obtained by mixing and grinding zinc oxide, metal silver, zirconium phosphate, zinc pyrithione and coconut oil fatty acid diacetamide. According to the invention, the sealant is prepared by compounding multi-component food-grade antibacterial mildew-proof active components, so that the prepared sealant is ensured to reach the first-grade standard of ASTM G21-15 Determination of Antifungal Factor of Synthetic High Polymer Materials, meanwhile, the risk that the sealant is mildewed when being used in canned food is reduced, and the quality of the product is improved.

The present disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in the treatment of infectious diseases, viral infections, and cancer, wherein the base of the nucleotide or nucleoside contains at least one thiol, thione, or thioether.

This invention discloses a photoactivated nanoparticle-based drug delivery material for immunoadjuvants, its preparation method, and its applications. The drug delivery material is constructed from photosensitizer monomers, crosslinking monomers, and immunoadjuvant prodrug monomers within a confined space of a nanoemulsion via a copper-free click polymerization reaction to form crosslinked polymer nanoparticles. The nanoparticle size is controllable, and the composition is precisely defined. Under physiological conditions, the drug delivery material exhibits good colloidal stability and high drug loading. Upon near-infrared light irradiation, the generated ROS can cleave the thioketone bonds, causing the nanoparticles to depolymerize and achieving photo-triggered, controllable release of the immunoadjuvant. Under photodynamic action, this drug delivery material efficiently generates reactive oxygen species to induce immunogenic cell death in tumor cells. Simultaneously, the released immunoadjuvant activates the TLR7 / 8 pathway, promotes dendritic cell maturation, and enhances the systemic anti-tumor immune response, thereby inhibiting the growth of tumors in situ and at distant sites, and reducing the risk of metastasis and recurrence.

A 1-hydroxyalkyl-5-mercapto-1,2,4-triazole-3-carboxylic acid compound of formula (1): in which R1, R2, R3 and R4 are each independently selected from the group consisting of hydrogen, unsubstituted and substituted C1-C18 alkyl, unsubstituted and substituted C1-C18 alkenyl, unsubstituted and substituted C3-C18 cycloalkyl, unsubstituted and substituted C6-C14 aryl, unsubstituted and substituted C1-C13 heteroaryl, unsubstituted and substituted C7-C18 aralkyl, unsubstituted and substituted C8-C18 arylalkenyl, and unsubstituted and substituted C7-C18 aryloxyalkyl, and n is 1, 2, 3 or 4. A preparation method for the 1-hydroxyalkyl-5-mercapto-1,2,4-triazole-3-carboxylic acid compound is also provided, in which a hydroxyalkylhydrazine compound is used as a starting material, and undergoes a condensation reaction, an addition-cyclization reaction and dehydrogenation in sequence to obtain the 1-hydroxyalkyl-5-mercapto-1,2,4-triazole-3-carboxylic acid compound. An use of such compound in the preparation of a 2-hydroxyalkyl-1,2,4-triazole-3-thione compound is also provided.

The invention relates to the technical field of lead-containing mineral wastewater treatment, in particular to a quinoline thioketone compound as well as a preparation method and application thereof. The invention provides a preparation method of a quinoline thioketone compound, and the quinoline thioketone compound prepared by the preparation method has good water phase response characteristics, and has ultrahigh selectivity and strong chelating precipitation capacity to Pb < 2 + > in a wide pH range.

The invention discloses a rubber composite material with marine antifouling property as well as a preparation method and application thereof, and relates to the technical field of marine fouling organism decay protection materials. The rubber composite material with the marine antifouling property comprises the following components which are blended and vulcanized: rubber, a filler, an antifouling agent, a plasticizer, an activating agent, a scorch retarder, an anti-aging agent, an accelerant and a vulcanizing agent, the antifouling agent comprises a copolymer modified by zwitter-ions and at least one of sodium benzoate, tannic acid, 6-gingerol, capsaicin, sulfobetaine, carboxylic acid betaine, phosphorylcholine, isothiazolinone and zinc pyrithione optionally selected from the group consisting of sodium benzoate, tannic acid, 6-gingerol, capsaicin, sulfobetaine, carboxylic acid betaine, phosphorylcholine, isothiazolinone and zinc pyrithione. The invention solves the three core problems of poor compatibility of an antifouling agent and a rubber matrix, short antifouling period caused by easy loss of the antifouling agent, and difficulty in balancing the antifouling property and mechanical property in the existing marine antifouling rubber material.

The invention is applicable to the technical field of chemical materials, and provides a method for regulating and controlling luminescence of Au nanoclusters by solvent-induced ligand isomerization, which comprises the following steps: firstly, synthesizing the gold nanoclusters with different surface isomer proportions by regulating the pH value of a reaction system; au (I)-thioketone and Au (I)-mercaptan isomer are induced to be reversibly converted by utilizing the interaction of solvent molecules and a cluster surface ligand structure, and proton coupling electron transfer kinetics is cooperatively regulated, so that the precise regulation of the luminescence property of the gold nanocluster is realized. According to the present invention, the wide band and the continuous reversible adjustment of the light-emitting wavelength in the range of 495-800 nm can be achieved under the mild condition, the light-emitting quantum yield can be significantly improved, and the method has advantages of simple operation, clear mechanism, greenness and universality, and has application prospects in the fields of biological imaging, optical sensing, light-emitting devices and the like.

This disclosure relates to nucleotide and nucleoside therapeutic compositions and their use in treating infectious diseases, viral infections and cancer, wherein the bases of said nucleotide or nucleoside contain at least one thiol, thion, or thioether.

The application discloses a rare earth compound flocculant and a preparation method and application thereof, and comprises a rare earth compound of gluconic acid, a rare earth compound of pyrithione and water, wherein the content of the rare earth compound of gluconic acid is 5-15 wt%, the rare earth compound of gluconic acid is prepared by reacting sodium gluconate and a first rare earth chloride salt in water; the content of the rare earth compound of pyrithione is 0.4-0.6 wt%, and the rare earth compound of pyrithione is prepared by reacting sodium pyrithione and a second rare earth chloride salt in water. The rare earth ions in the application have positive electricity, show extremely strong coordination ability and high coordination number. Meanwhile, the surface of Phaeodactylum tricornutum is negatively charged; therefore, when the rare earth ions contact with the Phaeodactylum tricornutum, the two can rapidly interact in electricity, cause the Phaeodactylum tricornutum to rapidly aggregate and form a mass, and then gradually precipitate.

This invention relates to a continuous flow method for preparing taurine, comprising the following steps: S1, using an alkaline solution of ethanolamine and a carbon disulfide solution as raw materials, simultaneously introducing them into a pressurized first continuous flow reactor to react and obtain a first reaction solution; S2, cooling, filtering, washing, and extracting the first reaction solution to obtain thiazolium-2-thione; S3, dissolving thiazolium-2-thione in an organic acid to obtain a thiazolium-2-thione solution; using the thiazolium-2-thione solution and hydrogen peroxide solution as raw materials, simultaneously introducing them into a second continuous flow reactor to react and obtain a second reaction solution, which is then post-treated to obtain taurine. This invention provides an ideal synthetic route, and through continuous flow reaction, the reaction time is short, resulting in high yield and purity of taurine, effectively reducing costs; the process is simple to operate, safe, and efficient, facilitating large-scale industrial production.

Examples of a biocide composition include an activated halogen compound selected from the group consisting of 2,2-dibromo-3-nitrlopropionamide; 2-bromo-2-nitropropane-1,3-diol; and 1,2-dibromo-2,4-dicyanobutane; benzisothiazolin-3-one; a pyridine-N-oxide selected from the group consisting of zinc pyrithione and sodium pyrithione; and a carbamate derivative selected from the group consisting of 3-iodo-2-propynyl butyl carbamate; zinc bis(dimethyldithiocarbamate); and bis(dimethyl carbamoyl) disulfide.

The invention belongs to the technical field of sponges, and particularly relates to an anti-mite, mildew-proof and antibacterial sponge which comprises the following components in parts by weight: 100 parts of polyether polyol; 45.1 to 51.0 parts of toluene diisocynate; 0.7 to 1.0 part of soft foam silicone oil; 0.12 to 0.28 part of an amine catalyst; 0.1 to 0.3 part of a tin catalyst; 2-3 parts of water; 0.5 to 0.9 part of a mildew-proof anti-mite antibacterial agent; the mildew-proof anti-mite antibacterial agent is a mixture of zinc pyrithione, permethrin and benzyl alcohol. Compared with the prior art, the sponge material with excellent performance is designed, the polyether polyol, the polymer polyol and the toluene diisocynate are used as main forming components of the sponge material, and the zinc pyrithione, the permethrin and the benzyl alcohol antibacterial and anti-mite agent are matched for use, so that the anti-mite, mildew-proof and antibacterial effects can be achieved; the sponge material prepared by the invention is comfortable and soft, has good elasticity, and also has relatively strong antibacterial, anti-mite and mildew-proof effects.

The invention belongs to the technical field of organic synthesis, and particularly relates to a thiazolopyrimidine compound as well as a preparation method and application thereof. The thiazolopyrimidine compound is efficiently prepared at room temperature and in an air atmosphere by taking pyrimidinethione and alpha-bromocinnamyl aldehyde as raw materials under the condition of no photocatalyst or additive. Compared with a previously reported preparation method, the method has the advantages of being green, environmentally friendly, safe, efficient and energy-saving, the substrate application range is wide, the compatibility of product functional groups is good, raw materials are easy to obtain, transition metal, a photocatalyst and an external oxidizing agent are not needed, and the medical intermediates and the medical molecules can be simply, conveniently and efficiently synthesized through the method.

The invention provides a preparation method of 5, 5-dimethyl isoxazolidine-3-thioketone and an intermediate thereof, and relates to the technical field of chemical synthesis. The preparation method comprises the following steps: mixing hydroxylamine hydrochloride, isopentenal, sulfide and a first alkali substance, and carrying out a reaction, so as to obtain the 5, 5-dimethyl isoxazolidine-3-thioketone. The hydroxylamine hydrochloride, the isopentenal, the sulfide and the first alkali substance directly react, and a simple and low-cost preparation route is constructed. In the process, a tedious halogenation step is omitted, highly toxic, stink and high-pollution dangerous reagents are completely abandoned, and emission of ammonia-nitrogen wastewater and stink gas is eliminated from the source. The system is mild and stable, and high-efficiency output of high-quality products is realized while extremely high safety and environmental friendliness are ensured.

The invention discloses a degradable thioketal (aldehyde) epoxy resin curing agent as well as a preparation method and application thereof, which can solve the problems of harsh degradation conditions, unadjustable degradation rate, poor thermal performance and the like of the existing epoxy resin material. The curing agent provided by the invention is simple in preparation method and low in toxicity, and can be prepared at a hectogram level or above; curing agents with different chemical structures can be obtained by replacing different reactants; the curing agent has various functional groups and can be further modified according to requirements; the degradation rate of the cured epoxy resin is adjustable, and the initial temperature of the curing reaction is diversified. Because thioketal has stable chemical properties, the cured epoxy resin has better thermal stability, thermal mechanical properties and acid-base stability than common degradable epoxy resin (Schiff base, ketal and the like), is equivalent to or even surpasses non-degradable epoxy resin, can be degraded in the presence of an oxidizing agent or metal ions, has unique degradation conditions, and is suitable for industrial production. A new thought is provided for epoxy resin degradation.

This invention discloses a chiral indothothiaran compound, its catalytic synthesis method, and its application as a HIF inhibitor, belonging to the field of biomedicine. The structure of the chiral indothothiaran compound is shown in general formula 3. Its catalytic synthesis method includes the following steps: using an alkynyl ketone compound 1 and an indole-2-thione compound 2 as reactants, adding a chiral primary amine catalyst and an acid additive, reacting in a substituted benzene solvent at 25-40°C for 24-48 hours to obtain the chiral indothothiaran compound shown in general formula 3. The chiral indothothiaran compound synthesized by this invention exhibits good inhibitory activity against hypoxia-inducible factor (HIF) and can be used to prepare drugs for the prevention or treatment of diseases related to HIF. The target product of this invention is directly obtained from commercially available raw materials through simple conversion, reducing the synthetic difficulty and making it suitable for large-scale preparation.

The invention relates to a cross-linked polymer, a polymer molded body and a preparation method and application thereof. The cross-linked polymer of the present invention has a cross-linked network formed by an addition reaction of 3, 4-dihydropyrimidine-2-thione (DHPMT) and an electron-deficient olefin. The cross-linked polymer disclosed by the invention has dynamic cross-linking property and ultraviolet protection property, is good in machinability and reprocessability, can be processed and formed in modes such as melt forming and the like, and can be repeatedly processed and formed for multiple times. The polymer forming body provided by the invention has good self-repairing capability, excellent light transmission and ultraviolet protection capability, and has good durability in a strong ultraviolet light environment.

The present application relates to a kind of 4-substituted-5H-1,2,3-dithiazole-5-thione and derivative and its synthesis method.The present application uses in non-metal iodine compound catalysis, methyl ketone compound, nitrogen-containing small molecule and elemental sulfur are converted into the technical scheme of 4-substituted-5H-1,2,3-dithiazole-5-thione and derivative.This technical scheme has the following advantages: the reagent required stable nature, need not pretreatment, cheap and easy to obtain;One-pot synthesis, the economy advantage of step is obvious, save time and effort;Without using transition metal catalysis, metal residue problem is eliminated from the root;Using cheap iodine compound catalysis, reduce environmental pollution, save reaction cost;Cheap and easy to obtain, safe and stable nitrogen-containing small molecule provides nitrogen source, elemental sulfur provides sulfur source, elemental sulfur provides two types of structures of per-sulfur bond and carbon-sulfur double bond in reaction;Whole reaction system is simple, reaction equipment is less, and operation is simple;The 4-substituted-5H-1,2,3-dithiazole-5-thione synthesized has good biological activity function, is potential drug molecule.

A method for preparing chiral tricyclic 3,4-dihydropyrimidine-2-thione compounds belongs to the field of synthetic chemistry. The method involves dissolving substituted benzaldehyde and thiourea in an organic solvent, then adding a chiral phosphorimide catalyst and additives, stirring at room temperature for 1-2 hours, followed by the addition of 1,3-indanedione, and reacting at 35-55°C for 30-60 hours. The resulting chiral tricyclic 3,4-dihydropyrimidine-2-thione compounds are purified. The molar ratio of substituted benzaldehyde, thiourea, chiral phosphorimide catalyst, 1,3-indanedione, and additives is 1:1-2.2:0.05-0.1:0.5-1.0:0.5-2.5, achieving a yield of 88% and an enantioselectivity of 99%. The reaction conditions are mild, and the reaction time is short, making this a highly efficient method for synthesizing chiral tricyclic 3,4-dihydropyrimidine-2-thione compounds.

The invention relates to the technical field of metal material surface treatment, in particular to a ball valve corrosion-resistant treatment process and a ball valve manufactured through the ball valve corrosion-resistant treatment process. The corrosion-resistant treatment process for the ball valve comprises the steps that the ball valve is pretreated, then a chemical plating solution is prepared, the pretreated ball valve is subjected to chemical plating, and the ball valve subjected to chemical plating is obtained; and finally, post-treatment is conducted, and the ball valve subjected to surface corrosion-resistant treatment is obtained. Wherein the chemical plating solution contains a leveling agent and an antioxidant; the leveling agent contains thiazolidinethione; the antioxidant contains sodium benzoate. According to the corrosion-resistant treatment process for the ball valve, the consistency of the thickness of a plating layer can be improved in the chemical plating process of the ball valve.

The invention discloses an antibacterial coating for leather shoes and a preparation method thereof, and belongs to the technical field of leather chemical engineering. The coating takes a waterborne polyurethane dispersion as a film forming matrix, and is matched with two newly designed antibacterial compounds, namely vinyl functionalized biguanide silane quaternary ammonium salt and nano-zinc loaded pyrithione silicon balls; and adding a cross-linking agent, a wetting leveling agent, a thickening agent, a coalescing agent and deionized water. Wherein the vinyl functionalized biguanide silane quaternary ammonium salt is prepared by reacting isocyanate silane with biguanide salt and then sequentially carrying out quaternization and epoxy ring-opening modification, and multiple antibacterial functional groups and polymerizable groups are integrated; the nano-zinc-loaded pyrithione silicon spheres are prepared by performing sulfhydrylation modification on mesoporous silica nanospheres and then reacting with pyridine oxide and zinc salt, and have both physical cutting and ion release sterilization mechanisms. And the obtained coating has strong adhesive force with leather shoe materials, is washing-resistant and friction-resistant, does not influence the air permeability and comfort of leather, and has a good application prospect.

This invention discloses a Cu4 cluster catalytic material with synergistic dual catalytic sites and its application in the hydroboration reaction, belonging to the interdisciplinary field of coordination chemistry and nanomaterials. This copper cluster, using N-heterocyclic thiones (methimazole) as protecting ligands, is synthesized in high yield via a simple one-pot method. The chemical formula of the cluster is: C 16 H 20 Cu4N8S4, abbreviated as Cu4NC, belongs to the tetragonal crystal system and has a space group of 1. P 42 / n, a =10.01930(10)Å, b =10.01930(10)Å, c =11.6512(2)Å, α =90°, β =90°, gamma =90°, V =1169.62(3)Å 3 This catalyst utilizes the advantages of its synergistic dual catalytic sites to achieve highly efficient and selective catalytic hydroboration of alkynes. It exhibits excellent chemoselectivity (up to 100%), high efficiency (conversion number (TON) = 77786), high yield (up to 99%), a broad substrate range (28), mild conditions (room temperature and air), and high recovery rate, which are beneficial for the development of functionalized cluster catalysts.

The invention discloses a compound and a composition used as a protein tyrosine phosphatase inhibitor, and belongs to the field of medicines. The invention provides a thiadiazolidine-3-thioketone compound with a structure as shown in a formula (I) or pharmaceutically acceptable salts thereof, and the compound has excellent protein tyrosine phosphatase inhibitory activity. A method of treatment of a disease or condition (e.g., cancer, type 2 diabetes, obesity, metabolic disease or any other disease, condition or condition) that is positively responsive to a protein tyrosine phosphatase (PTPN2 or PTPN1) inhibitor is provided.

The application discloses a curcumin analogue, a preparation method and application thereof, and has a structural formula of (E)-3-((1H-indol-3-yl)methylene)-5-((E)-4-mercaptobenzylidene)-1-methylpiperidine-4-thione. The compound is synthesized through a plurality of reaction steps, including aldehyde acylation, cyclization, thio reaction and condensation reaction. In-vitro experiments show that the IC50 value of the compound to triple-negative breast cancer cells MDA-MB-231 is 3.69+ / -0.89 muM, which is significantly better than existing chemotherapeutic drugs. Cell experiments show that the compound can effectively inhibit tumor growth and induce cell apoptosis, and has the potential to be developed into an anti-triple-negative breast cancer drug.

This disclosure relates to therapeutic compositions of nucleotides and nucleosides and their use in the treatment of infectious diseases, viral infections and cancer, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether.

The present invention provides a compound of formula (I) for use in the treatment or prevention of pathological conditions associated with increased expression and activity of TREX2, wherein: A1 is a group of formula (II); a2 is a ring system consisting of one or two rings wherein each ring is saturated, partially saturated or unsaturated and has 5 or 6 members selected from the group consisting of: N, O, S, C, NRp, CRz and C (Rz) 2; a3 represents X7-(X8) n; x1 represents CR1 or N; x2 represents CR2 or N; x3 represents CR3 or N; x4 represents CR4 or N; x5 represents CR5 or N; x6 represents CR6 or N; x7 represents CR7 or N; and X8 represents CR8 or N; with the proviso that one, two or three of X1 to X8 are N; and n is an integer selected from 0 or 1. The present invention also provides compounds of formula (Ibis), pharmaceutical compositions comprising the same, and methods of making the same.