167 results about "Mitochondrial targeting" patented technology

The invention discloses astaxanthin nanoparticles as well as a preparation method and application thereof. The astaxanthin nanoparticles comprise 58%-68% w/w of casein, 7%-11% w/w of a chitosan-TPP compound, 24%-28% w/w of sodium alginate and 0.5%-7% w/w of astaxanthin. According to the astaxanthin nanoparticles, casein I is used for primary embedding of the astaxanthin, the chitosan-TPP compoundand the sodium alginate are further subjected to layer-by-layer self-assembly through electrostatic interaction, and pH response type and mitochondrial targeting type nanoparticles are constructed andformed. According to the method, gastric acid escape can be achieved, the release rate of the astaxanthin in intestinal tract is increased, compared with the mode that free astaxanthin can be concentrated and enriched in the colons of mice, the colitis of the mice is relieved, and the targeting effect on cell mitochondria is achieved, the embedding protection mode of the method constructs a functional characteristic nanometer carrying system, and the absorption and utilization degree of nutrients is fully improved.