299 results about "Melatonin" patented technology

Sleep-aiding eyewear that prevents light which inhibits melatonin production from reaching the eye is described. The eyewear that is the object of the present disclosure has improved visibility over other methods of cutting off melatonin-inhibiting wavelengths of light, which enables the user to perform tasks, such as reading and typing, uninhibited. This is achieved in some embodiments using a Bragg grating comprising multiple layers of alternating reflective index material as a surface coating on the lens. This may be combined with lens-tinting, or antireflective coatings, in the eyewear. Furthermore, transition lenses which block melatonin-shifting light when there is a suitable external stimulus, such as blue light from a light emitting diode, are described. The presently described filters are also useful for electronic displays and functional light-transmitting materials.

The invention relates to the technical field of exosomes, in particular to an exosome compound preparation with a hair growing effect and a preparation method of the exosome compound preparation. Comprising 12 to 22 parts of ginsenoside Rb1, 15 to 12 parts of biotin tripeptide-15, 8 to 15 parts of diammonium glycyrrhizinate, 50 to 70 parts of fish collagen peptide, 10 to 20 parts of soybean peptide, 0.5 to 4.5 parts of SHH protein, 0.5 to 2.5 parts of SMO inhibitor, 0.5 to 1.5 parts of HhSP protein, 5 to 10 parts of N-acetyl tyrosine, 0.1 to 2 parts of hyaluronic acid, 0.1 to 1 part of melatonin, 0.1 to 1 part of quercetin, 0.1 to 1 part of kaempferol, 0.1 to 1 part of tanshinone, 0.1 to 1 part of biotin and 0.1 to 1 part of vitamin A. The compound preparation is combined with exosomes from various sources, so that the hair papilla cell function is synergistically enhanced, and the damaged hair follicle structure is repaired.

The invention discloses a compound composition for improving sleep disorders, which is characterized by comprising the following components: an inhibitory neurotransmitter component, melatonin and a nano-lipid carrier, the nano-lipid carrier comprises phospholipid and cholesterol, the weight ratio of phospholipid to cholesterol is (1-6): 1, the weight ratio of phospholipid to cholesterol is (1-6): 1, and the weight ratio of melatonin to cholesterol is (1-6): 1. The inhibitory neurotransmitter component is wrapped in the nano-lipid carrier to form lipid nanoparticles, and the weight ratio of the inhibitory neurotransmitter component to the nano-lipid carrier is 1: (1-15). The compound composition can be prepared into a compound oral mucosa preparation, can be rapidly disintegrated when encountering saliva in the oral cavity, is good in patient compliance and small in side effect, all the components play a synergistic effect from different mechanisms through multiple target points, and the compound oral mucosa preparation can improve the sleep quality, prolong the sleep time and shorten the sleep latency; and patients with sleep disorders are helped to improve insomnia from the pathologic root.

The invention discloses a sleep-aiding traditional Chinese medicine composition and a preparation method and application thereof. The sleep-aiding traditional Chinese medicine composition is prepared from 50-80 parts of spina date seeds, 50-80 parts of polygala tenuifolia, 50-80 parts of lilies, 50-80 parts of poria cocos, 30-50 parts of red dates, 30-50 parts of lotus seeds, 30-50 parts of longan aril, 30-50 parts of mulberries, 20-30 parts of seaweed polyphenols and 20-30 parts of gamma-aminobutyric acid. Pharmacodynamic tests show that the composition can remarkably shorten the sleep latency time of mice, prolong the total sleep time and remarkably improve the levels of 5-hydroxytryptamine, melatonin and gamma-aminobutyric acid in serum of the mice, so that the composition has an obvious sleep aiding effect through scientific proportioning and synergistic interaction of the raw materials.

The invention belongs to the technical field of sleep-aiding gels, and discloses a herbal sleep-aiding gel and a preparation process thereof, the gel comprises the following components: deionized water, propylene glycol, glycerol, carbomer 980 and triethanolamine; the mask is prepared from, by weight, 1.8% of lavender essential oil, chamomile extract, bitter orange flower essential oil, gamma-aminobutyric acid, melatonin, spina date seed extract, xylaria nigripes extract and phospholipid wall materials. Sodium chloride and azone; camphor and borneol; eDTA (Ethylene Diamine Tetraacetic Acid) disodium, phenoxyethanol and ethylhexylglycerin. The traditional Chinese medicine composition is suitable for people with sleep disorders such as long-term insomnia, difficulty in falling asleep, insomnia and dreaminess, easy awakening due to light sleep, restlessness and depression and the like; through the high transdermal absorption rate of a nano micro-capsule technology, in combination with a colloid double-electrode-layer structure, capacitance-like micro-current is generated, in cooperation with lavender-chamomile-bitter orange flower and other herbal essence and GABA and melatonin active ingredients, the sleep center is adjusted in a multi-channel mode, and the physical sleep-aiding scheme is a new physical sleep-aiding scheme for safely replacing a sleeping drug.

The invention is suitable for the technical field of health care, and provides a health-care food formula for improving sleep. Comprising the following raw materials in parts by weight: 150-250 parts of whole-grain oatmeal, 100-200 parts of germinated brown rice powder, 60-80 parts of pumpkin seeds, 50-60 parts of black sesame, 40-50 parts of flaxseeds, 62-70 parts of dried sour cherries, 55-60 parts of dried figs, 45-52 parts of dried bananas, 20-25 parts of chamomile flower powder, 18-20 parts of ground cinnamon, 50-60 parts of fructus cannabis protein powder, 70-80 parts of millet powder, 35-40 parts of hericium erinaceus powder and 18-20 parts of ganoderma lucidum spore powder. The beverage is prepared from 48-50 parts of fructo-oligosaccharide, 35-40 parts of date palm paste, 25-30 parts of beer yeast powder, 28-30 parts of walnut oil, 15-20 parts of semen ziziphi spinosae and 10-15 parts of semen boitae. Various nutritional foods are adopted, so that the problem of difficulty in falling asleep caused by insufficient secretion of melatonin can be solved, and anxiety, light sleep caused by excessive activity of brain waves and the like can be relieved.

The invention discloses an oral sleep-aiding composition containing ergothioneine and a preparation method of the oral sleep-aiding composition, and relates to the technical field of sleep-aiding compositions. The oral sleep-aiding composition containing the ergothioneine is prepared from the following components in parts by mass: 0.01 to 3 parts of the ergothioneine, 0.1 to 10 parts of melatonin, 10 to 40 parts of glycine, 2 to 15 parts of magnesium salt, 30 to 70 parts of a diluent, 1 to 10 parts of an adhesive, 0.5 to 5 parts of a lubricant, 2 to 10 parts of a disintegrating agent and 0.1 to 0.5 part of an antioxidant preservative. Through the synergistic compatibility of ergothioneine, melatonin, glycine and magnesium salt, a multi-dimensional action network of oxidation resistance, neuromodulation and receptor inhibition is formed, the limitation of single-component sleep aiding is broken through, and the sleeping efficiency and the sleep maintenance capability are remarkably improved. Based on the scientific proportion of endogenous substances (ergothioneine and glycine), the metabolic burden of traditional sleep-aiding components is avoided, and in combination with the design of a sustained-release preparation, the dose-dependent side effects are reduced, and the safety of long-term taking is improved.

The invention discloses a melatonin rapidly disintegrating oral tablet and a preparation method thereof, and the melatonin rapidly disintegrating oral tablet is prepared from the following raw materials in parts by weight: 40 to 55 parts of mannitol, 3 to 6 parts of cross-linked povidone, 0.5 to 2.0 parts of povidone, 2 to 6 parts of melatonin, 30 to 45 parts of filler and 0.3 to 1.5 parts of lubricant. Wherein the mannitol is beta-crystal form mannitol. According to the invention, mannitol of a limited type is matched with raw materials such as polyvinylpolypyrrolidone, and meanwhile, a specific mixing and tabletting process is adopted, so that the tablet can be rapidly disintegrated in an oral cavity while the hardness of the tablet is maintained, the bioavailability is high, and the requirements of the health food field on taking convenience, effectiveness and industrial production can be met.

The invention relates to the technical field of plant stress regulation and medicinal plant cultivation. A salt stress damage repair method for cutting seedlings of aromatic medicinal plants comprises the following steps: after asexual cutting seedlings of the aromatic medicinal plants suffer from salt stress, spraying a melatonin aqueous solution with the concentration of 50-200 [mu] mol.L to the leaves of the seedlings in a repair window period of 3-6 days after the salt stress occurs, spraying 1-2 times a day, continuously spraying for 2-3 days, and continuously spraying the melatonin aqueous solution with the concentration of 50-200 [mu] mol.L to the leaves of the seedlings in the repair window period of 3-6 days after the salt stress occurs. Melatonin is used for repairing salt damage of the asexual cuttage seedlings of the aromatic medicinal plants. The melatonin can be accurately applied before the salt damage critical point to repair the physiological damage of the cutting seedlings of the aromatic medicinal plants, and the salt damage influence of the cutting seedlings of the aromatic medicinal plants is greatly reduced; the problems that cutting seedlings of the aromatic medicinal plants are prone to salt damage under salt stress, the survival rate is low, and the content of main medicinal components is reduced are solved, and the dual effects of seedling physiological restoration and medicinal component content stabilization can be achieved.

The invention discloses a melatonin detection method which comprises the following steps: S1, coupling an anti-melatonin antibody with a PE fluorescent label with carboxyl fluorescent magnetic beads to construct antibody coupled magnetic beads MBs (at) Ab; s2, preparing a melatonin analogue FITC-MT by using the 5-MT and the FITC-NHS (N-hydroxysuccinimide); s3, preparing MBs (at) Ab and FITC-MT into a reaction system, reacting with melatonin standard substances with different concentrations or a to-be-detected sample, detecting by using a flow cytometer, processing a detection result of the flow cytometer by using a machine learning algorithm, and calculating the melatonin concentration in the to-be-detected sample. MT in a to-be-detected sample can compete for FITC-MT combined with MBs (at) Ab in a short time to form a stable reaction system, the multi-dimensional features of MBs (at) Ab are subjected to flow detection to directly remove impurities, agglomeration and the like in MBs (at) Ab, different fluorescence features of an optimal magnetic bead group in the system are searched and analyzed in combination with a machine learning algorithm, and the content of MT can be accurately detected; the reaction system constructed by the invention is simple to operate and extremely low in cost, and meanwhile, the result accuracy can be ensured.

The invention discloses a method for promoting biomass accumulation of haematococcus pluvialis, which comprises the following steps: adding salicylic acid, melatonin and alpha-ketoglutaric acid into a basic culture medium, and replacing ferric trichloride with ferric citrate as an iron source to obtain an improved BG-11 culture medium; the method comprises the following steps: inoculating a haematococcus pluvialis seed solution into a culture bottle containing an improved culture medium, carrying out illumination treatment on the first day to the second day by adopting pulsed red light with the wavelength of 620 nm in the early stage of a green stage, carrying out illumination treatment on the third day to the fifth day by adopting red light with the wavelength of 660 nm in the middle stage of the green stage, and carrying out illumination treatment on the sixth day to the seventh day by adopting pulsed red light with the wavelength of 680 nm in the later stage of the green stage. Through a synergistic scheme of the improved BG-11 culture medium, staged red light treatment and dynamic environment regulation and control, the problems of low light energy utilization rate and insufficient stress resistance in the existing haematococcus pluvialis culture process are solved, high efficiency and stability of haematococcus pluvialis biomass accumulation are realized, the biomass can reach 7.0 * 10 < 5 > cells / mL in the later period of the green stage, and the yield of the haematococcus pluvialis can reach 7.0 * 10 < 5 > cells / mL in the later period of the green stage. And the survival rate of haematococcus pluvialis cells reaches 95%.

The invention provides a microbial marker and a prediction model for schizophrenia with social anxiety disorder. The microbial marker is a Bacteroides microorganism in saliva. The relevance between the relative abundance of Bacteroides microorganisms in saliva and social anxiety disorder is found for the first time. A Nomogram clinical prediction mode is formed by taking the specific microbial marker as a microbial marker in combination with a children bad experience scale and 6-hydroxymelatonin and 5-hydroxyindoleacetic acid in serum, so that objective biological indexes can be provided for early diagnosis and monitoring of whether schizophrenia is accompanied by social anxiety disorder or not; errors of subjective evaluation are reduced; moreover, the oral saliva sample has the obvious advantage of being easy to collect for psychiatric patients, the working difficulty of medical staff can be greatly reduced, and revolutionary changes of prediction, diagnosis and treatment of schizophrenia accompanied with social anxiety disorder are expected to be brought.

The invention relates to the technical field of plant conditioners, in particular to application of nano silicon dioxide in relieving stress of polystyrene microplastics on hibiscus mutabilis. The invention finds that the influence of polystyrene micro-plastic on the stress of hibiscus mutabilis can be relieved to a certain extent during treatment by nano-silica, the intervention of the nano-silica causes the increase of secretion of melatonin, and the combined action of the nano-silica and melatonin makes the effect more remarkable and shows a synergistic effect. The nano silicon dioxide directly acts on the surfaces of cells to form a protective layer, so that adsorption and damage of PS-MPs to the cells are reduced, synthesis of melatonin is promoted, and a melatonin signal channel is activated. The activated melatonin signaling pathway further regulates the activity of carbon and nitrogen metabolism key enzymes, promotes carbon and nitrogen metabolism, improves synthesis and accumulation of carbohydrates and proteins, enhances the activity of an antioxidant system, removes active oxygen and reduces oxidative damage.

The invention discloses a multi-mode light-supplementing sleep-aiding control circuit, device and system integrating sound, light and smell, and a control method, and relates to the technical field of electronic circuits. The circuit comprises a main control module, a light supplementing module, a sleep-aiding lamplight module, an environment sensing module, an aromatherapy module, a power amplifier loudspeaker module and the like, low-blue-light soft and brightness-adjustable illumination is output through the light supplementing module, and the problems of too strong blue light, screen stroboflash and reading fatigue when an intelligent terminal is used are solved. The sleep-aiding light module can be adjusted to warm color temperature, the mood is relaxed, and illumination secreted by melatonin is not damaged. The environment sensing module collects environment light and proximity distance information in real time, so that the equipment can intelligently adjust the light supplementing brightness and the sleep-aiding lamp mode; hot fumigation closed-loop control is adopted for the aromatherapy module, constant-temperature adjustment is achieved through temperature sampling, and volatilization of sleep-aiding fragrance is more stable and safer; the power amplifier loudspeaker module provides stable output for white noise, natural sound and rhythmic respiration guiding sound, and provides reliable acoustic assistance for sleep adjustment.

The application belongs to the field of biology and discloses a rice OsCSA gene and a method for improving the copper stress resistance of rice, and more specifically discloses OsCSA application of the gene in improving the copper stress resistance of rice, through transcriptome analysis of rice under copper stress and verification under different experimental conditions under copper stress, it is found that OsCSA the gene has a close relationship with accumulation of melatonin in rice, and it is proved that OsCSA the gene and the melatonin have the ability to improve the copper stress resistance level of rice. Meanwhile, the application also discloses OsCOMT9 application of the gene and / or OsCOMT12 application of the gene and a method for improving the copper stress resistance of rice.

1. Name of the product of this design: Packaging box (Melatonin Magnesium HETDS transdermal patch). 2. Purpose of this design product: used for product packaging. 3. The key design point of this product lies in the combination of pattern and color. 4. The picture or photo that best illustrates the key points of the design: Design 1 Stereoscopic Figure 1. 5. The design for which protection is sought includes color. 6. Designate Design 1 as the base design.

The present application belongs to the technical field of plant tissue culture, and particularly relates to a high-efficiency rooting and seedling raising method for plant tissue culture seedlings, S1 trimming and disinfection of S2 induction liquid immersion, S3 composite substrate implantation and gradient environment regulation, S4 substrate transplanting and planting; the core is to use modified magnetic biochar composite substrate loaded with FeO nanoparticles, cooperate with the synergistic effect of microencapsulated rooting hormone and melatonin, realize in-situ integrated seedling raising through composite spectrum containing UV-A, CO pulse supply, gradient humidity and PEG osmotic pressure domestication. The present application effectively inhibits basal browning, shortens the seedling raising period, improves the rooting quality and transplanting survival rate, overcomes the pollution prejudice of magnetic nanoparticles, is suitable for woody and herbaceous plants, and can be applied to plant tissue culture seedling production on a large scale.

The invention provides application of platanus sp. Su100 in promotion of synthesis of poplar melatonin and disease resistance, and relates to the technical field of microbial resource development and forest cultivation. The soft disc fungus Su100 can activate the activity of a key enzyme for synthesizing melatonin in a poplar body, and the content of the melatonin is remarkably increased. As a plant endogenous antioxidant and a multifunctional signal molecule, the melatonin plays a core role in plant stress resistance, growth regulation and control, quality improvement and ecological restoration. The floppy disc fungi have high colonization efficiency in plants, and can form a symbiotic system with the poplar by utilizing a floppy disc fungi inoculation technology to play a role for a long time. The application of the invention can significantly reduce the production cost of agriculture and forestry, is especially suitable for crop cultivation under the adverse conditions of drought, salt and alkali, diseases and the like, reduces the application of chemical fertilizers and pesticides, and lays a foundation for the construction of an efficient, green and sustainable forestry planting and cultivation system.

The invention provides a preparation method of biomass aerogel for inhibiting spontaneous combustion of coal through synergistic modification of dopamine and melatonin, and the method comprises the following steps: adding carboxylated cellulose nanofiber, sodium alginate and melatonin into a NaOH aqueous solution containing urea to obtain CNF-C / SA / MT copolymer mixed sol, adding epoxy chloropropane, stirring, adding dopamine to form DOPA / CNF-C / SA / MT gel, and carrying out vacuum drying to obtain the biomass aerogel for inhibiting spontaneous combustion of coal through synergistic modification of dopamine and melatonin. After sealing and curing, standing at 60 DEG C to form hydrogel, curing and soaking with deionized water, and freeze-drying to obtain the biomass aerogel for inhibiting spontaneous combustion of coal through synergistic modification of dopamine and melatonin. The invention also provides application of the biomass aerogel for inhibiting spontaneous combustion of coal through synergistic modification of dopamine and melatonin. The biomass aerogel is used for inhibiting and delaying a spontaneous combustion oxidation reaction of coal. The biomass aerogel for inhibiting spontaneous combustion of coal through synergistic modification of dopamine and melatonin prepared by the invention uniformly covers the surface of a coal body, so that a synergistic effect of inhibiting spontaneous combustion of coal is realized.

1. Name of the product under this design: packaging bottle (melatonin chewable tablets). 2. Purpose of this design product: used for the outer packaging of melatonin chewable tablets. 3. The key design point of this design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

Provided herein are compositions for the prevention and treatment of demodex blepharitis in a subject and processes of treatment or prevention of demodex blepharitis. The compositions may include at least one avermectin compound selected from 5-O-demethyl-22,23-dihydroavermectin A1a or 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)avermectin A1a, or a combination thereof, and melatonin, wherein an aggregate concentration of the avermectin compound is optionally less than 1 wt %. Further devices are provided that include wipe including a woven or non-woven membrane and a treatment composition, the treatment composition including melatonin, one or more anti-microbial compounds, and optionally one or more pharmaceutically acceptable excipients and processes of treatment or prevention of demodex blepharitis in a subject using the wipe, alone or optionally further with the composition as provided herein.

The invention discloses application of spermidine in in-vitro culture of human unfrozen oocytes and embryos. By adding the combination of spermidine, melatonin and astaxanthin into the thawed oocyte resuscitation culture solution and the embryo in-vitro culture solution, the mitochondrial autophagy and mitochondrial functions of the thawed oocytes are improved, so that the in-vitro culture effect of the thawed oocytes and embryos is improved, and the success rate of an assisted reproduction technology is increased.

The invention discloses a multi-system function regeneration factor composition as well as a preparation method and application thereof. The multi-system function regeneration factor composition is prepared from the following components in parts by mass: 0.8 to 2.4 parts of melatonin, 84 to 126 parts of nicotinamide ribose and 42 to 84 parts of resveratrol. According to the multi-system functional regeneration factor composition disclosed by the invention, through scientific proportioning and synergistic effect of melatonin, nicotinamide ribose and resveratrol, the functions of stem cells are strongly activated, proliferation of the stem cells is remarkably promoted, the stemness maintaining capability of the stem cells is improved, osteogenesis and adipogenesis differentiation potential is enhanced, and the regeneration effect of the stem cells is improved. Meanwhile, an NAD < + > metabolic pathway is activated so as to strengthen cell energy and anti-aging capability. The capsule adopts the design of combining quick-release pellets and sustained-release pellets, the quick-release part can quickly release melatonin, the local drug concentration can be increased in a short time, and stem cell activation signals can be quickly started; and the sustained release part slowly releases nicotinamide ribose and resveratrol to maintain the long-acting stability of the drug concentration, so that the effect taking speed is ensured, the action time is prolonged, and the bioavailability is greatly improved.

This invention belongs to the field of biotechnology and discloses a dry film stabilizer, cytoplasmic antigen dry films, their preparation methods, and applications. The dry film stabilizer includes polyethylene glycol, trehalose, BSA, melatonin, and Tween-20. Cytoplasmic antigen dry films are prepared using this stabilizer and applied in CBA detection. This dry film stabilizer has good permeability, penetrating the cell membrane to enter the cell interior, providing protection both inside and outside the cell. It also possesses moisturizing and antioxidant properties, preventing cell deformation and shedding of the cell fixation layer, effectively maintaining the stability and reliability of intracellular antigen proteins. The prepared cytoplasmic antigen dry films can be stored long-term without damaging the antigenicity of cytoplasmic signal indicators. When detecting positive samples, strong and numerous green filamentous fluorescence signals are observed in the cytoplasm, with consistent green and red fluorescence intensities. Software synthesis reveals co-localization of green and red antigen fluorescence.

The invention relates to the field of genetic engineering and fermentation engineering, and discloses a genetically engineered bacterium for producing melatonin and application of the genetically engineered bacterium in fermentation production of melatonin. According to the invention, genes of mtrA, PTPS, SPR, PCD and DHPR of related enzymes synthesized by coding 2-amino-6-(1, 2-dihydroxypropyl)-5, 6, 7, 8-tetrahydro-4 (1H)-pterin diketone and genes of L-2-amino-3 (beta-indole) propionic acid monooxygenase, oxymethyltransferase, N-acetyltransferase and decarboxylase are co-expressed on the genetically engineered bacterium, so that the gene engineering bacterium is obtained. The strain can be used for fermentation production of melatonin, and experiments show that the yield of the strain can reach 6480 mg / L.

The invention relates to application of an mRNA-loaded exosome in preparation of a medicine for preventing and / or treating myocardial ischemia reperfusion, and belongs to the technical field of biological medicines. The invention provides an application of an exosome loaded with mRNA (messenger ribonucleic acid) as shown in SEQ ID NO.1 in preparation of a medicine for preventing and / or treating myocardial ischemia reperfusion. The prepared exosome or the exosome and melatonin are combined for administration, myocardial ischemia reperfusion injury can be effectively prevented and / or treated, and the exosome has the advantages of being good in treatment effect, high in biological safety, low in side effect and high in targeting performance and systematicness.

The application discloses a CKD and IgAN early detection method based on blood mass spectrum analysis, utilizes liquid chromatography-tandem mass spectrometry technology to detect 24 kinds of compounds of a plasma sample in a targeted manner, utilizes a logic regression to establish an early detection model of CKD and IgAN, and verifies the prediction accuracy of CKD and IgAN in a cohort. Through analysis of plasma samples of healthy controls and CKD patients (including IgAN and non-IgAN patients), it is proved that the melatonin or melatonin+tryptophan level in the plasma is an effective method for detecting early CKD, and the melatonin, tryptophan, indole-3-lactic acid, indole-3-carboxylic acid, kynurenic acid and indole-3-methyl aldehyde are effective methods for detecting early IgAN. The application provides effective blood markers for early detection of CKD and IgAN.

It is an object of the present invention to provide a composition in a solid form, preferably in the form of a multilayer gummy with differentiated release of active ingredients.

This invention discloses a sleep-aid composition that synergistically regulates sleep rhythm with 5-HTP and L-theanine, relating to the fields of biomedicine and health food technology. This invention effectively regulates sleep rhythm through the synergistic effect of 5-hydroxytryptophan, L-theanine, and γ-aminobutyric acid (GABA), helping users improve sleep quality. 5-HTP, as a precursor to serotonin, helps increase serotonin levels, which are then converted into melatonin, regulating the sleep cycle. L-theanine promotes the release of alpha brain waves, helping to relax the mind and body and reduce anxiety. GABA, as an inhibitory neurotransmitter, effectively relieves tension and promotes deep sleep. The synergistic effect of these three components provides users with more comprehensive and effective sleep support.

The invention belongs to the technical field of agricultural product preservation, and discloses a lettuce preservation method which comprises the following steps: raw material selection and pretreatment: harvesting fresh lettuce with proper maturity, removing outer leaves and impurities, washing surface floating dust with clear water, and draining for later use; preparation of a melatonin solution: dissolving melatonin in a small amount of methanol, and diluting with distilled water to a target concentration; spraying the picked lettuce with a melatonin aqueous solution, and draining the lettuce subjected to spraying treatment; and storing the drained lettuce in a normal temperature environment of 20-25 DEG C or a refrigeration environment of 4 + / -1 DEG C. The method can prolong the shelf life of the lettuce and maintain the freshness, nutrition and sensory quality of the lettuce.