375 results about "Melatonin" patented technology

The invention belongs to the technical field of food microorganisms, and relates to lactobacillus plantarum and application thereof in preparation of products for relieving insomnia. The preservation number of the lactobacillus plantarum is GDMCC No: 65061. The lactobacillus plantarum can be applied to efficient fermentation of spina date seed juice, the content of GABA, polypeptide, total phenols and total flavonoids in the spina date seed juice is increased, and the content of spinosin, 6 ''-feruloyl spinosin, jujuboside A, jujuboside B and betulinic acid is increased; the reduction of whole brain coefficient and the increase of liver coefficient caused by long-term insomnia are relieved, the bad condition caused by long-term insomnia in a hippocampus DG region in the brain of the mouse is improved, the sleep time of the mouse is prolonged, and the insomnia symptom of the mouse is relieved; the content of inhibitory neurotransmitters 5-hydroxytryptamine, melatonin and gamma-aminobutyric acid in the hypothalamus of the mouse is increased, the content of excitatory neurotransmitter glutamic acid is reduced, and the reduction of organism immunity and oxidative stress of brain tissues caused by insomnia are relieved.

Sleep-aiding eyewear that prevents light which inhibits melatonin production from reaching the eye is described. The eyewear that is the object of the present disclosure has improved visibility over other methods of cutting off melatonin-inhibiting wavelengths of light, which enables the user to perform tasks, such as reading and typing, uninhibited. This is achieved in some embodiments using a Bragg grating comprising multiple layers of alternating reflective index material as a surface coating on the lens. This may be combined with lens-tinting, or antireflective coatings, in the eyewear. Furthermore, transition lenses which block melatonin-shifting light when there is a suitable external stimulus, such as blue light from a light emitting diode, are described. The presently described filters are also useful for electronic displays and functional light-transmitting materials.

The invention relates to the technical field of exosomes, in particular to an exosome compound preparation with a hair growing effect and a preparation method of the exosome compound preparation. Comprising 12 to 22 parts of ginsenoside Rb1, 15 to 12 parts of biotin tripeptide-15, 8 to 15 parts of diammonium glycyrrhizinate, 50 to 70 parts of fish collagen peptide, 10 to 20 parts of soybean peptide, 0.5 to 4.5 parts of SHH protein, 0.5 to 2.5 parts of SMO inhibitor, 0.5 to 1.5 parts of HhSP protein, 5 to 10 parts of N-acetyl tyrosine, 0.1 to 2 parts of hyaluronic acid, 0.1 to 1 part of melatonin, 0.1 to 1 part of quercetin, 0.1 to 1 part of kaempferol, 0.1 to 1 part of tanshinone, 0.1 to 1 part of biotin and 0.1 to 1 part of vitamin A. The compound preparation is combined with exosomes from various sources, so that the hair papilla cell function is synergistically enhanced, and the damaged hair follicle structure is repaired.

The invention discloses a compound composition for improving sleep disorders, which is characterized by comprising the following components: an inhibitory neurotransmitter component, melatonin and a nano-lipid carrier, the nano-lipid carrier comprises phospholipid and cholesterol, the weight ratio of phospholipid to cholesterol is (1-6): 1, the weight ratio of phospholipid to cholesterol is (1-6): 1, and the weight ratio of melatonin to cholesterol is (1-6): 1. The inhibitory neurotransmitter component is wrapped in the nano-lipid carrier to form lipid nanoparticles, and the weight ratio of the inhibitory neurotransmitter component to the nano-lipid carrier is 1: (1-15). The compound composition can be prepared into a compound oral mucosa preparation, can be rapidly disintegrated when encountering saliva in the oral cavity, is good in patient compliance and small in side effect, all the components play a synergistic effect from different mechanisms through multiple target points, and the compound oral mucosa preparation can improve the sleep quality, prolong the sleep time and shorten the sleep latency; and patients with sleep disorders are helped to improve insomnia from the pathologic root.

The invention provides a feed domesticated siniperca chuatsi sperm low-temperature preservation and ultralow-temperature preservation method, which comprises the following steps: firstly, providing a siniperca chuatsi sperm low-temperature preservation diluent which comprises Hanks liquid, sodium chloride, soya bean lecithin, vitamin E, curcumin, melatonin and SOD (superoxide dismutase); and adding an anti-freezing protective agent into the low-temperature preservation diluent to obtain the ultralow-temperature preservation anti-freezing liquid for the siniperca chuatsi sperms. The siniperca chuatsi semen and the low-temperature preservation diluent are uniformly mixed, so that low-temperature preservation can be realized; the siniperca chuatsi semen is uniformly mixed with the cryopreservation anti-freezing liquid, so that cryopreservation can be realized. The siniperca chuatsi sperm low-temperature preservation diluent is preferably selected, low-temperature preservation of the siniperca chuatsi sperms can be achieved, ultralow-temperature preservation can be conducted after an anti-freezing protective agent is added, the persistence of the preservation time of the siniperca chuatsi sperms can be guaranteed, the protection effect on the sperms is good, and the activation rate and activity of the unfrozen sperms are high.

The invention discloses a self-adaptive display definition optimization system and method based on time variation, and the system comprises a time detection module which is used for obtaining the information of a current time period; the ambient light sensor is used for detecting ambient light intensity and color temperature; the display parameter adjusting module is used for dynamically adjusting the resolution, sharpness, color temperature, brightness and blue light proportion of the display according to the time period and the ambient light data; the user habit learning module is used for analyzing user manual adjustment records and optimizing default parameters; the eye protection mode module is used for triggering protective adjustment of display parameters according to the continuous use duration; according to the invention, the resolution and sharpness can be automatically adjusted according to different time periods, and the definition and the visual comfort are balanced; blue light radiation is intelligently reduced at night, and interference on melatonin secretion is reduced; unnecessary display parameters are automatically reduced according to ambient light and time, and the endurance of equipment is prolonged; and a customized display mode is provided by learning user habits.

The invention discloses a sleep-aiding traditional Chinese medicine composition and a preparation method and application thereof. The sleep-aiding traditional Chinese medicine composition is prepared from 50-80 parts of spina date seeds, 50-80 parts of polygala tenuifolia, 50-80 parts of lilies, 50-80 parts of poria cocos, 30-50 parts of red dates, 30-50 parts of lotus seeds, 30-50 parts of longan aril, 30-50 parts of mulberries, 20-30 parts of seaweed polyphenols and 20-30 parts of gamma-aminobutyric acid. Pharmacodynamic tests show that the composition can remarkably shorten the sleep latency time of mice, prolong the total sleep time and remarkably improve the levels of 5-hydroxytryptamine, melatonin and gamma-aminobutyric acid in serum of the mice, so that the composition has an obvious sleep aiding effect through scientific proportioning and synergistic interaction of the raw materials.

The invention belongs to the technical field of sleep-aiding gels, and discloses a herbal sleep-aiding gel and a preparation process thereof, the gel comprises the following components: deionized water, propylene glycol, glycerol, carbomer 980 and triethanolamine; the mask is prepared from, by weight, 1.8% of lavender essential oil, chamomile extract, bitter orange flower essential oil, gamma-aminobutyric acid, melatonin, spina date seed extract, xylaria nigripes extract and phospholipid wall materials. Sodium chloride and azone; camphor and borneol; eDTA (Ethylene Diamine Tetraacetic Acid) disodium, phenoxyethanol and ethylhexylglycerin. The traditional Chinese medicine composition is suitable for people with sleep disorders such as long-term insomnia, difficulty in falling asleep, insomnia and dreaminess, easy awakening due to light sleep, restlessness and depression and the like; through the high transdermal absorption rate of a nano micro-capsule technology, in combination with a colloid double-electrode-layer structure, capacitance-like micro-current is generated, in cooperation with lavender-chamomile-bitter orange flower and other herbal essence and GABA and melatonin active ingredients, the sleep center is adjusted in a multi-channel mode, and the physical sleep-aiding scheme is a new physical sleep-aiding scheme for safely replacing a sleeping drug.

The method comprises the following steps: fixing with a pre-fixing solution, wrapping and forming with a solid agent, fixing with a fixing solution, embedding with an embedding agent, decomposing melanin with a melanin decomposing solution, pre-decoloring with a pre-decoloring solution, decoloring with a decoloring solution, and eluting with a rinsing solution. The invention provides a melanin removing method capable of effectively avoiding retina RPE layer cell exfoliation, protein denaturation and nucleic acid degradation. The method mainly comprises the following steps: keeping the original state of tissue cells by adopting a pre-fixing solution, keeping the complete tissue structure by adopting a solid agent, decomposing melanin particles by adopting a melanin decomposing solution composed of various extracts, separating melanin by adopting a pre-decoloring solution and a decoloring solution, eluting the melanin decomposed on the surface of the tissue by adopting a rinsing solution, and the like. On the premise that the retina tissue structure is intact and protein, nucleic acid and cell structures on the surface of the tissue section are not damaged, melanin particles in the tissue section are effectively decomposed, the biological activity of various organelles on the surface of the section is kept, and the requirements of subsequent chemical staining of various tissues are met.

The invention is suitable for the technical field of health care, and provides a health-care food formula for improving sleep. Comprising the following raw materials in parts by weight: 150-250 parts of whole-grain oatmeal, 100-200 parts of germinated brown rice powder, 60-80 parts of pumpkin seeds, 50-60 parts of black sesame, 40-50 parts of flaxseeds, 62-70 parts of dried sour cherries, 55-60 parts of dried figs, 45-52 parts of dried bananas, 20-25 parts of chamomile flower powder, 18-20 parts of ground cinnamon, 50-60 parts of fructus cannabis protein powder, 70-80 parts of millet powder, 35-40 parts of hericium erinaceus powder and 18-20 parts of ganoderma lucidum spore powder. The beverage is prepared from 48-50 parts of fructo-oligosaccharide, 35-40 parts of date palm paste, 25-30 parts of beer yeast powder, 28-30 parts of walnut oil, 15-20 parts of semen ziziphi spinosae and 10-15 parts of semen boitae. Various nutritional foods are adopted, so that the problem of difficulty in falling asleep caused by insufficient secretion of melatonin can be solved, and anxiety, light sleep caused by excessive activity of brain waves and the like can be relieved.

The invention discloses an oral sleep-aiding composition containing ergothioneine and a preparation method of the oral sleep-aiding composition, and relates to the technical field of sleep-aiding compositions. The oral sleep-aiding composition containing the ergothioneine is prepared from the following components in parts by mass: 0.01 to 3 parts of the ergothioneine, 0.1 to 10 parts of melatonin, 10 to 40 parts of glycine, 2 to 15 parts of magnesium salt, 30 to 70 parts of a diluent, 1 to 10 parts of an adhesive, 0.5 to 5 parts of a lubricant, 2 to 10 parts of a disintegrating agent and 0.1 to 0.5 part of an antioxidant preservative. Through the synergistic compatibility of ergothioneine, melatonin, glycine and magnesium salt, a multi-dimensional action network of oxidation resistance, neuromodulation and receptor inhibition is formed, the limitation of single-component sleep aiding is broken through, and the sleeping efficiency and the sleep maintenance capability are remarkably improved. Based on the scientific proportion of endogenous substances (ergothioneine and glycine), the metabolic burden of traditional sleep-aiding components is avoided, and in combination with the design of a sustained-release preparation, the dose-dependent side effects are reduced, and the safety of long-term taking is improved.

The invention discloses a melatonin rapidly disintegrating oral tablet and a preparation method thereof, and the melatonin rapidly disintegrating oral tablet is prepared from the following raw materials in parts by weight: 40 to 55 parts of mannitol, 3 to 6 parts of cross-linked povidone, 0.5 to 2.0 parts of povidone, 2 to 6 parts of melatonin, 30 to 45 parts of filler and 0.3 to 1.5 parts of lubricant. Wherein the mannitol is beta-crystal form mannitol. According to the invention, mannitol of a limited type is matched with raw materials such as polyvinylpolypyrrolidone, and meanwhile, a specific mixing and tabletting process is adopted, so that the tablet can be rapidly disintegrated in an oral cavity while the hardness of the tablet is maintained, the bioavailability is high, and the requirements of the health food field on taking convenience, effectiveness and industrial production can be met.

The invention belongs to the technical field of functional preparations, and discloses a composite emulsion for improving insomnia and a preparation method thereof. The composite emulsion is prepared from the following components in percentage by volume: 70 to 95 percent of modified fucoidin solution with the concentration of 0.5 to 3 mg / mL, and the balance of melatonin-containing medium chain triglyceride, the content of the melatonin in the composite emulsion is 0.02 wt%. The compound emulsion is strong in stability and high in bioavailability, and can effectively resist an acid environment in a stomach and protect melatonin from being delivered to intestinal tracts. Through verification, the average core sleep duration of a subject taking the compound emulsion is increased by 21.05% compared with that of the subject taking melatonin only; the average waking time is shortened by 40% compared with that of melatonin, and the effect is remarkable.

The invention relates to the technical field of plant stress regulation and medicinal plant cultivation. A salt stress damage repair method for cutting seedlings of aromatic medicinal plants comprises the following steps: after asexual cutting seedlings of the aromatic medicinal plants suffer from salt stress, spraying a melatonin aqueous solution with the concentration of 50-200 [mu] mol.L to the leaves of the seedlings in a repair window period of 3-6 days after the salt stress occurs, spraying 1-2 times a day, continuously spraying for 2-3 days, and continuously spraying the melatonin aqueous solution with the concentration of 50-200 [mu] mol.L to the leaves of the seedlings in the repair window period of 3-6 days after the salt stress occurs. Melatonin is used for repairing salt damage of the asexual cuttage seedlings of the aromatic medicinal plants. The melatonin can be accurately applied before the salt damage critical point to repair the physiological damage of the cutting seedlings of the aromatic medicinal plants, and the salt damage influence of the cutting seedlings of the aromatic medicinal plants is greatly reduced; the problems that cutting seedlings of the aromatic medicinal plants are prone to salt damage under salt stress, the survival rate is low, and the content of main medicinal components is reduced are solved, and the dual effects of seedling physiological restoration and medicinal component content stabilization can be achieved.

The invention discloses a melatonin detection method which comprises the following steps: S1, coupling an anti-melatonin antibody with a PE fluorescent label with carboxyl fluorescent magnetic beads to construct antibody coupled magnetic beads MBs (at) Ab; s2, preparing a melatonin analogue FITC-MT by using the 5-MT and the FITC-NHS (N-hydroxysuccinimide); s3, preparing MBs (at) Ab and FITC-MT into a reaction system, reacting with melatonin standard substances with different concentrations or a to-be-detected sample, detecting by using a flow cytometer, processing a detection result of the flow cytometer by using a machine learning algorithm, and calculating the melatonin concentration in the to-be-detected sample. MT in a to-be-detected sample can compete for FITC-MT combined with MBs (at) Ab in a short time to form a stable reaction system, the multi-dimensional features of MBs (at) Ab are subjected to flow detection to directly remove impurities, agglomeration and the like in MBs (at) Ab, different fluorescence features of an optimal magnetic bead group in the system are searched and analyzed in combination with a machine learning algorithm, and the content of MT can be accurately detected; the reaction system constructed by the invention is simple to operate and extremely low in cost, and meanwhile, the result accuracy can be ensured.

The invention discloses a method for promoting biomass accumulation of haematococcus pluvialis, which comprises the following steps: adding salicylic acid, melatonin and alpha-ketoglutaric acid into a basic culture medium, and replacing ferric trichloride with ferric citrate as an iron source to obtain an improved BG-11 culture medium; the method comprises the following steps: inoculating a haematococcus pluvialis seed solution into a culture bottle containing an improved culture medium, carrying out illumination treatment on the first day to the second day by adopting pulsed red light with the wavelength of 620 nm in the early stage of a green stage, carrying out illumination treatment on the third day to the fifth day by adopting red light with the wavelength of 660 nm in the middle stage of the green stage, and carrying out illumination treatment on the sixth day to the seventh day by adopting pulsed red light with the wavelength of 680 nm in the later stage of the green stage. Through a synergistic scheme of the improved BG-11 culture medium, staged red light treatment and dynamic environment regulation and control, the problems of low light energy utilization rate and insufficient stress resistance in the existing haematococcus pluvialis culture process are solved, high efficiency and stability of haematococcus pluvialis biomass accumulation are realized, the biomass can reach 7.0 * 10 < 5 > cells / mL in the later period of the green stage, and the yield of the haematococcus pluvialis can reach 7.0 * 10 < 5 > cells / mL in the later period of the green stage. And the survival rate of haematococcus pluvialis cells reaches 95%.

The invention provides a microbial marker and a prediction model for schizophrenia with social anxiety disorder. The microbial marker is a Bacteroides microorganism in saliva. The relevance between the relative abundance of Bacteroides microorganisms in saliva and social anxiety disorder is found for the first time. A Nomogram clinical prediction mode is formed by taking the specific microbial marker as a microbial marker in combination with a children bad experience scale and 6-hydroxymelatonin and 5-hydroxyindoleacetic acid in serum, so that objective biological indexes can be provided for early diagnosis and monitoring of whether schizophrenia is accompanied by social anxiety disorder or not; errors of subjective evaluation are reduced; moreover, the oral saliva sample has the obvious advantage of being easy to collect for psychiatric patients, the working difficulty of medical staff can be greatly reduced, and revolutionary changes of prediction, diagnosis and treatment of schizophrenia accompanied with social anxiety disorder are expected to be brought.

The invention belongs to the technical field of animal gene engineering, and particularly relates to a down producing goat lncRNA, an interference vector and application of the interference vector to regulation and control of down producing goat hair follicle development, the down producing goat lncRNA is lncRNA TCONS-00237214 and is used for regulating and controlling down producing goat hair follicle development; the nucleotide sequence of the lncRNA TCONS-00237214 is as shown in SEQ ID NO. 1 (sequence identifier number 1). According to the invention, the hair papilla cells are selected for subsequent experimental verification, and the cell cycle, cell proliferation and cell migration of the hair papilla cells are detected by constructing an interference lncRNA TCONS-00237214 stable transformation hair papilla cell line. Results of the invention show that melatonin can regulate and control expression of lncRNA TCONS-00237214, participate in cell cycle transformation, promote proliferation and migration of hair papilla cells and inhibit apoptosis of the hair papilla cells, thereby affecting generation and development of hair follicles.

The invention relates to the technical field of plant genetic engineering, in particular to a medicago sativa MsSNAT1 gene and application of the medicago sativa MsSNAT1 gene in regulation and control of plant salt tolerance. The nucleotide sequence of the medicago sativa MsSNAT1 gene is as shown in SEQ ID NO. 1. Experimental results show that overexpression of the MsSNAT1 gene enhances the stress resistance of medicago sativa. The overexpression of the MsSNAT1 gene promotes the increase of the content of endogenous melatonin and increases the expression of the melatonin synthetase gene under salt stress. Compared with a wild type, the antioxidant enzyme activity and osmoregulation substance increase trend of the transgenic line under salt and drought stress is more obvious, the MDA content is lower, and the negative influence is smaller. In addition, the content of endogenous melatonin in a transgenic line is increased, and the endogenous melatonin and exogenous ABA act together, so that the oxidation resistance and osmotic regulation capacity of the plant are enhanced, and the stress resistance of the plant is remarkably improved.

Provided is a cattle whole genome SNP chip, the chip containing 50,000 SNP sites. The SNP chip comprises milk production traits, milk composition traits, reproductive traits and melatonin traits of cattle. The described molecular marker combination is used to construct a whole genome breeding chip, used for molecular breeding of cattle.

The invention relates to the technical field of plant conditioners, in particular to application of nano silicon dioxide in relieving stress of polystyrene microplastics on hibiscus mutabilis. The invention finds that the influence of polystyrene micro-plastic on the stress of hibiscus mutabilis can be relieved to a certain extent during treatment by nano-silica, the intervention of the nano-silica causes the increase of secretion of melatonin, and the combined action of the nano-silica and melatonin makes the effect more remarkable and shows a synergistic effect. The nano silicon dioxide directly acts on the surfaces of cells to form a protective layer, so that adsorption and damage of PS-MPs to the cells are reduced, synthesis of melatonin is promoted, and a melatonin signal channel is activated. The activated melatonin signaling pathway further regulates the activity of carbon and nitrogen metabolism key enzymes, promotes carbon and nitrogen metabolism, improves synthesis and accumulation of carbohydrates and proteins, enhances the activity of an antioxidant system, removes active oxygen and reduces oxidative damage.

The invention provides a goat semen cryopreservation solution. The goat semen cryopreservation solution comprises melatonin and one or more of sodium citrate, fructose, yolk, glycerol, penicillin, streptomycin and tris (hydroxymethyl) aminomethane. The cryopreservation liquid is used for preserving goat semen and can improve the pregnancy rate of long-term infertility ewes.

The invention discloses a multi-mode light-supplementing sleep-aiding control circuit, device and system integrating sound, light and smell, and a control method, and relates to the technical field of electronic circuits. The circuit comprises a main control module, a light supplementing module, a sleep-aiding lamplight module, an environment sensing module, an aromatherapy module, a power amplifier loudspeaker module and the like, low-blue-light soft and brightness-adjustable illumination is output through the light supplementing module, and the problems of too strong blue light, screen stroboflash and reading fatigue when an intelligent terminal is used are solved. The sleep-aiding light module can be adjusted to warm color temperature, the mood is relaxed, and illumination secreted by melatonin is not damaged. The environment sensing module collects environment light and proximity distance information in real time, so that the equipment can intelligently adjust the light supplementing brightness and the sleep-aiding lamp mode; hot fumigation closed-loop control is adopted for the aromatherapy module, constant-temperature adjustment is achieved through temperature sampling, and volatilization of sleep-aiding fragrance is more stable and safer; the power amplifier loudspeaker module provides stable output for white noise, natural sound and rhythmic respiration guiding sound, and provides reliable acoustic assistance for sleep adjustment.

The application belongs to the field of biology and discloses a rice OsCSA gene and a method for improving the copper stress resistance of rice, and more specifically discloses OsCSA application of the gene in improving the copper stress resistance of rice, through transcriptome analysis of rice under copper stress and verification under different experimental conditions under copper stress, it is found that OsCSA the gene has a close relationship with accumulation of melatonin in rice, and it is proved that OsCSA the gene and the melatonin have the ability to improve the copper stress resistance level of rice. Meanwhile, the application also discloses OsCOMT9 application of the gene and / or OsCOMT12 application of the gene and a method for improving the copper stress resistance of rice.

1. Name of the product of this design: Packaging box (Melatonin Magnesium HETDS transdermal patch). 2. Purpose of this design product: used for product packaging. 3. The key design point of this product lies in the combination of pattern and color. 4. The picture or photo that best illustrates the key points of the design: Design 1 Stereoscopic Figure 1. 5. The design for which protection is sought includes color. 6. Designate Design 1 as the base design.

The present application belongs to the technical field of plant tissue culture, and particularly relates to a high-efficiency rooting and seedling raising method for plant tissue culture seedlings, S1 trimming and disinfection of S2 induction liquid immersion, S3 composite substrate implantation and gradient environment regulation, S4 substrate transplanting and planting; the core is to use modified magnetic biochar composite substrate loaded with FeO nanoparticles, cooperate with the synergistic effect of microencapsulated rooting hormone and melatonin, realize in-situ integrated seedling raising through composite spectrum containing UV-A, CO pulse supply, gradient humidity and PEG osmotic pressure domestication. The present application effectively inhibits basal browning, shortens the seedling raising period, improves the rooting quality and transplanting survival rate, overcomes the pollution prejudice of magnetic nanoparticles, is suitable for woody and herbaceous plants, and can be applied to plant tissue culture seedling production on a large scale.

The invention provides application of platanus sp. Su100 in promotion of synthesis of poplar melatonin and disease resistance, and relates to the technical field of microbial resource development and forest cultivation. The soft disc fungus Su100 can activate the activity of a key enzyme for synthesizing melatonin in a poplar body, and the content of the melatonin is remarkably increased. As a plant endogenous antioxidant and a multifunctional signal molecule, the melatonin plays a core role in plant stress resistance, growth regulation and control, quality improvement and ecological restoration. The floppy disc fungi have high colonization efficiency in plants, and can form a symbiotic system with the poplar by utilizing a floppy disc fungi inoculation technology to play a role for a long time. The application of the invention can significantly reduce the production cost of agriculture and forestry, is especially suitable for crop cultivation under the adverse conditions of drought, salt and alkali, diseases and the like, reduces the application of chemical fertilizers and pesticides, and lays a foundation for the construction of an efficient, green and sustainable forestry planting and cultivation system.

The invention provides a preparation method of biomass aerogel for inhibiting spontaneous combustion of coal through synergistic modification of dopamine and melatonin, and the method comprises the following steps: adding carboxylated cellulose nanofiber, sodium alginate and melatonin into a NaOH aqueous solution containing urea to obtain CNF-C / SA / MT copolymer mixed sol, adding epoxy chloropropane, stirring, adding dopamine to form DOPA / CNF-C / SA / MT gel, and carrying out vacuum drying to obtain the biomass aerogel for inhibiting spontaneous combustion of coal through synergistic modification of dopamine and melatonin. After sealing and curing, standing at 60 DEG C to form hydrogel, curing and soaking with deionized water, and freeze-drying to obtain the biomass aerogel for inhibiting spontaneous combustion of coal through synergistic modification of dopamine and melatonin. The invention also provides application of the biomass aerogel for inhibiting spontaneous combustion of coal through synergistic modification of dopamine and melatonin. The biomass aerogel is used for inhibiting and delaying a spontaneous combustion oxidation reaction of coal. The biomass aerogel for inhibiting spontaneous combustion of coal through synergistic modification of dopamine and melatonin prepared by the invention uniformly covers the surface of a coal body, so that a synergistic effect of inhibiting spontaneous combustion of coal is realized.

1. Name of the product under this design: packaging bottle (melatonin chewable tablets). 2. Purpose of this design product: used for the outer packaging of melatonin chewable tablets. 3. The key design point of this design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

Provided herein are compositions for the prevention and treatment of demodex blepharitis in a subject and processes of treatment or prevention of demodex blepharitis. The compositions may include at least one avermectin compound selected from 5-O-demethyl-22,23-dihydroavermectin A1a or 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)avermectin A1a, or a combination thereof, and melatonin, wherein an aggregate concentration of the avermectin compound is optionally less than 1 wt %. Further devices are provided that include wipe including a woven or non-woven membrane and a treatment composition, the treatment composition including melatonin, one or more anti-microbial compounds, and optionally one or more pharmaceutically acceptable excipients and processes of treatment or prevention of demodex blepharitis in a subject using the wipe, alone or optionally further with the composition as provided herein.