721 results about "Immune regulation" patented technology

Disclosed are methods, compositions of matter, and protocols useful for the induction of a therapeutic immune modulatory response through administration of exosomes derived from a stem cell source. In one embodiment, said stem cell source is endometrial regenerative cells. Specifically, in one embodiment stem cell derived exosomes are used as a method of treating an autoimmune condition such as rheumatoid arthritis, multiple sclerosis, or systemic lupus erythromatosis.

Disclosed are cells, methods of modulating cells, and therapeutic uses of the cells for the immune modulation of mammals in need thereof. Immune modulation including alteration of cytokine profile, cytotoxic activity, antibody production and inflammatory states is achieved through the administration of various cell types that have been unmanipulated or manipulated in order to endow specific biological activity. Cellular subsets and administration of the subsets in combination with various agents are also provided. One embodiment teaches the previously unknown finding that adipose tissue derived mononuclear cells contain T cells with immune regulatory properties that alone or synergistically with various stem cells induce immune modulation upon administration. Another embodiment is the finding that stimulation of stem cell activation results in stem cell secondary activation of immune modulatory cells, one type which is T regulatory cells (Tregs). One specific embodiment involves extraction of a heterogenous stem cell pool, which contains T regulatory cells, treatment in culture of the population with agents known to stimulate stem cell activation, then subsequent extraction and administration of the purified Tregs. Other embodiments include expansion of Tregs in the presence of antigen in order to generate anti-specific Tregs.

Methods and systems for the treatment for ALS incorporating stem cells harvested from the subject to be treated. These stem cells may be genetically altered with the addition of several genes of interest. Then, the patient will receive systemic gene therapy for the muscles and directed specifically at motor neurons. In this multi-pronged treatment approach, the stem cells provide immune regulation and the regeneration of motor neurons. And, the new motor neurons carry the added genes, which are protective against motor neuron death from ALS. The systemic therapy increases the amount of genes, which further reduces the effects of ALS. Additional gene therapy administered in the muscle will be further protective of the axon, while maintaining muscle mass and function.

Disclosed is a composition for administration to a human or animal subject, the composition containing spores of Bacillus subtilis in an amount effective to stimulate immune responsiveness in the subject. The spores have an adjuvant, immunomodulatory, immune potentiation, or dendritic cell maturation effect, or a combination thereof Also disclosed is a method of boosting an immune response in an animal subject by administering B. subtilis spores to an animal or human subject. Further disclosed is a vaccine containing B. subtilis spores, in the presence or absence of an antigen.

The present invention is related generally to embryonic-like stem cells isolated from human umbilical cord blood, designated herein as cord blood-stem cells (CB-SC's), which display the characteristics of embryonic stem cells and hematopoietic cells. These cells have the capability of proliferation and are able to differentiate to multiple types of cells. In addition, the CB-SC display low immunogenicity and immune regulation. These cells are, therefore, suitable for use in stem cell-based therapies for the treatment of diseases such as Parkinson's disease, diabetes, spinal cord damage, multiple sclerosis, cardiovascular disease, stroke and birth defects, and for preventing, treating and/or reducing an autoimmune disease in a mammalian subject.

The present invention discloses a method for extracting coix seed oil by using supercritical CO2 extraction process, and is characterized by that it makes the CO2 being in supercritical state by matched with entraining agent to implement extraction of coix seed, and its yield of coix seed oil can be up to above 8.18%. Said coix seed oil contains lots of unsaturated fatty acid and protein, can be used for preparing the medicine for curing cancer, making immune regulation, reducing blood fat, relieving inflammation and relieving cough, at the same time can be used for developing various function health-care foods.

The invention relates to a culture medium efficiently amplifying autologous NK cells and a culture method. The culture medium internally contains interleukin 2(IL-2), interleukin 15(IL-15), interleukin 7(IL-7), interleukin 12(IL-12), tumor necrosis factor alpha (TNFalpha) and CD3-antibody, can efficiently amplify and activate NK cells so as to obtain a large quantity of highly active immune cells with majority of NK cells to be transferred back to human bodies, and has remarkable curative effect in anti-tumor, anti-virus infection and immune adjustment related diseases. The culture medium efficiently amplifying autologous NK cells comprises the culture medium for cultivating cells and added factors added into the culture medium for cultivating cells, is used for cultivating and amplifying a large quantity of autologous activated NK cells, and is characterized in that the added factor comprises interleukin 2(IL-2), interleukin 15(IL-15), interleukin 7(IL-7), interleukin 12(IL-12), tumor necrosis factor alpha (TNF alpha) and CD3-antibody.

The invention discloses a giant salamander functional food with an immune regulation action and a preparation method thereof. The giant salamander functional food is prepared by obtaining giant salamander enzymatic hydrolysis powder by carrying out treatment of cell disruption, enzymatic hydrolysis and spray drying on giant salamander meat and then mixing the giant salamander enzymatic hydrolysis powder with extractive powder of medical and edible dual purpose plants including medlar, jujube and hawthorn and auxiliary materials according to a certain proportion. The preparation method keeps the nutrition activity of the giant salamander meat to the maximum extent, enhances the nutrition utilization ratio of a human body and also has the advantages of simple preparation process, convenient operation, safety, reliability, low production cost, and the like. The giant salamander meat functional food has the effects of eliminating oxygen free radicals, delaying aging and enhancing the immunity, is combined with the nourishing function of other medical and edible dual purpose plants so as to enhance the resistant ability of the human body to various diseases through long-term eating, strengthen the adaptability of the human body to the environment and be beneficial to the recovery of a patient after a surgery or with a weak constitution and is an ideal functional food.

Disclosed are CD70 binding agents, such as anti-CD70 antibodies and derivatives, that induce a cytotoxic, cytostatic or immunomodulatory without conjugation to a therapeutic agents as well as pharmaceutical compositions and kits comprising the antibody or derivative. Also disclosed are methods for the treatment and prevention of CD70-expressing cancers and immunological disorders comprising administering the CD70 binding agents to a subject.

The invention provides a hawthorn vinegar healthy beverage, which is characterized by comprising the following raw materials in weight portion: 40 to 80 portions of hawthorn, 40 to 80 portions of honey, 40 to 80 portions of xylitol, 50 to 100 portions of white vinegar, 0.25 to 0.5 portion of aspartame, and 650 to 850 portions of water, and the hawthorn vinegar is prepared by a certain method. The hawthorn vinegar has disease prevention efficacy of table vinegar, good flavor of juice, palateful sweet and sour and sweet taste, and is suitable to be directly drunk. The hawthorn vinegar is rich in various amino acids, organic acid, vitamin, mineral and other nutritious ingredients, and has efficacies of blood-fat reduction, vessel relaxing, oxidation resistance, immunity regulation, harmful bacteria elimination, balance maintenance for blood acid alkali, weight reduction, digestion help and sobering up and the like.

The invention provides a pig IFN (interferon) gamma-Fc fusion protein optimized according to a silkworm reaction system and a coding gene of the pig IFNgamma-Fc fusion protein and a method of expressing pig IFNgamma-Fc fusion protein by using a silkworm bioreactor, and belongs to the field of a biological genetic engineering. The pig interferon gamma serving as a non-special broad spectrum antiviral biological agent has a wide medicinal prospect in a veterinary drug field; but like most of genetic engineering veterinary drugs, the pig interferon gamma also has the problems such as insufficient output, expensive price, irregular quality, short acting time and the like. A target protein with a high expression efficiency and strong activity is obtained by expressing the pig IFNgamma-Fc fusion protein optimized by using a silkworm expression system. In addition, the acting time of the pig interferon gamma is prolonged by addition of an Fc segment, so that the overall immune regulation effect is enhanced, and purification at a later stage is facilitated, thus a pig IFNgamma-Fc fusion protein preparation produced by using a genetic engineering method is possible, and a condition is also created for developing a novel feed containing the fusion protein.

The invention relates to the field of protein, in particular to a bioactive peptide SKVLPVPEKAVPYPQ as well as a preparation method and an application thereof. An amino acid sequence of the bioactive peptide SKVLPVPEKAVPYPQ is Ser-Lys-Val-Leu-Pro-Val-Pro-Glu-Lys-Ala-Val-Pro-Tyr-Pro-Gln. An in-vitro anti-oxidation experiment and an in-vitro immunity function promoting experiment prove that the bioactive peptide SKVLPVPEKAVPYPQ has better anti-oxidation biological activity and immunity regulation function, on one hand, the bioactive peptide SKVLPVPEKAVPYPQ has better anti-oxidation activity, can clear free radicals in an organism and improves life quality; on the other hand, by the aid of the bioactive peptide SKVLPVPEKAVPYPQ, in-vitro proliferation capacity of lymphocytes and macrophages can be enhanced, the phagocytosis capacity of the macrophages for neutral red is improved, the organism's capacity of resisting outside pathogen infection is improved, morbidity of the organism is reduced, and therefore, the bioactive peptide SKVLPVPEKAVPYPQ has quite great significance in development of food, healthcare products and drugs with an immune regulation function and an anti-oxidation function.

The present invention relates to the field of protein, and in particular relates to biologically active polypeptide WNIPMGLIVNQ and a preparation method and the application thereof, and the amino acid sequence of the biologically active polypeptide WNIPMGLIVNQ is Trp-Asn-Ile-Pro-Met-Gly-Leu-Ile-Val-Asn-Gln. In vitro antioxidant experiments and in vitro immune function promotion experiments verify the biologically active polypeptide WNIPMGLIVNQ has good antioxidant biological activity and immunity regulating function, on the one hand, the biologically active polypeptide WNIPMGLIVNQ has good antioxidant activity to remove free radicals in the body and improve the quality of life; on the other hand, the biologically active polypeptide WNIPMGLIVNQ can enhance the in-vitro proliferation ability of lymphocytes and macrophages to promote the increase of macrophage induced nitric oxide, the biologically active polypeptide WNIPMGLIVNQ can improve the external pathogen infection resistance of the body and reduce the disease incidence of the body, and has very important significance for development of food, health care products and drugs with immune function regulating and antioxidant function.

Calcareous materials which are very purified residues of corallinaceae particulary Lithothamnium corallioides have unusual therapeutic properties including treatment of conditions created by failure of immune regulation, for example rheumatoid or osteo arthritis, osteoporosis and other conditions involving pH control. A method for purification is provided. Also provided are compositions of the residues together with fatty acids, glycerides, polyglycols and emulsifiers. Particularly advantageous are compositions of the residues and medium chain triglycerides.

The invention relates to a method for preparing cholesterol reducing eggnog fermenting drink by utilizing lactobacillus and microzyme which produce bile salt hydrolase, belonging to a functional drinkwhich is prepared from the following ingredients: 15% of whole egg pulp, 35% of milk, 7% of saccharose, 0.3% of CMC-Na. and 0.2% of carrageenin, wherein the ratio of the raw materials (the whole eggplug and the milk) to water is 1:1 (W/V). The primary fermentation condition is described as following: streptococcus thermophilus Tx, Lactococcus lactis subsp.lactis KS4 and Lactobacillus casei KL1 are mixed in proportion of 1:1:1, the inoculum size is 3%, and then the mixture is fermented for 8h at the temperature of 43 DEG C. The secondary fermentation condition is described as following: Kluyveromyces marxianus M3 and K1 are compounded in proportion of 1:1 or the inoculum size of the single strain is 1%, and then the composite is fermented for 24-26 h at the temperature of 30 DEG C (mixture strain) or 32-34 DEG C; after ripening is carried out for 1 day at the temperature of 4 DEG C, the reducing rate of raw material cholesterol reaches as high as 89.3%. By utilizing the characteristics of strain high-yielding BSH, exopolysaccharide and the like, the invention has the efficiencies of immunological regulation, cholesterol reducing, tumor prevention and the like, and the problem of egg smell is not only solved, but also the content of raw material cholesterol is efficiently reduced through egg pulp proper sterilization and eggnog secondary fermentation. The eggnog drink preparedby the invention has simple fermentation process, short period and lower cost and is suitable for industrialized production.

The invention discloses a fermented type Chinese herbal medicine immunological enhancer for finless eel, which has a plurality of effects of prevention, health care, treatment, immune regulation and the like, and is an ideal, green, environment-friendly, safe and novel feed additive for substituting antibiotics medicaments. The fermented type Chinese herbal medicine feed additive is prepared from compound Chinese herbal medicines through processes of Chinese herbal medicine ultrasonic-assisted extraction and multi-strain two-step fermentation, has double advantages of the Chinese herbal medicines and probiotics, can effectively regulate intestinal health of the finless eel, can treat both symptoms and root causes, can supporting the healthy energy and cultivate vigor, can keep intestinal tract microecological balance and the optimal immune state, can improve digestibility of nutrition substances, can improve immunity of the finless eel body, can increase breeding income, can lower breeding risks, can substitute antibiotics in use, has no bad influences on the finless eel, and is safe to use and free from problems such as medicine residue and medicament resistance, has a wide market prospect.