Bursa of Fabricius heptapeptide with immune regulation effect

A technology of immune regulation and bursa, which is applied in the field of immunology, can solve the problem of promoting PFC activity loss, and achieve the effect of promoting cellular immune response, wide application prospects, and extremely weak immunogenicity
CN101830968AInactive Publication Date: 2010-09-15NANJING AGRICULTURAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NANJING AGRICULTURAL UNIVERSITY
Publication Date
2010-09-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to bursa of Fabricius heptapeptide with immune regulation effect and application thereof in immunity (in improving the immune capability of animals, improving the immune effect of vaccines and affecting the activity of tumor cells), and belongs to the field of immunology. The molecular weight of the separated heptapeptide is 722.240, the amino acid sequence is EPASGMM, and the heptapeptide has a simple structure, no toxic or side effect and extremely weak immunogenic property. The heptapeptide can be separated and extracted from bursa of Fabricius, also can be chemically synthesized, has low cost, and can be massively produced. The bursa of Fabricius heptapeptide has induction effect on the production of antibody and subtype thereof, and meanwhile can regulate the production of cell factors, partition of T lymphocytes and proliferation of spleen cells, and promote the immune reaction of the cells. The bursa of Fabricius heptapeptide is an immune regulation factor on functions, has wide application prospect on the aspects of immune regulation, immune therapy and the like, and can be applied in the fields of basic immune research, clinical application research and the like.
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Description

1. Technical field

[0001] The invention relates to a bursal heptapeptide with immunoregulatory effect and its application in immunity (improving the immune ability of animals, improving the immune effect of vaccines and affecting the activity of tumor cells), belonging to the field of immunology. 2. Background technology

[0002] The bursa of Fabricus (BF) was first discovered by Hieronymus Fabricus in 1961. At the same time, the shape and location of the supraluminal bursa were clarified, so it was named bursa of Fabricus. The bursa of Fabricius is the central lymphoid organ of humoral immunity unique to poultry. It is located on the dorsal side of the cloaca. Its blind end is sac-shaped and faces the front of the body. Early researchers observed that the bursa gradually degenerates with sexual maturity, so it has always been considered an organ related to reproductive physiology. Since 1956, when Glick and others discovered that removing the bursa of Fabricius would reduc...

Claims

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