62 results about "Acetonitrile" patented technology

The invention relates to a flow battery carbon-based electrode and a preparation method and application thereof, and the preparation method comprises the following steps: respectively dissolving cobalt salt and alkali in a polar organic solvent, and uniformly mixing to form a precursor solution; placing a carbon-based material in the precursor solution, and carrying out a hydrothermal reaction to obtain a carbon-based electrode precursor; and performing high-temperature carbonization on the carbon-based electrode precursor in an inert atmosphere, cooling to room temperature after the reaction is completed, and then cleaning and removing impurities from a product to obtain the carbon-based electrode, the polar organic solvent is at least one of formamide, acetonitrile and N, N-dimethylformamide; after cobalt cyanide is deposited on the surface of the carbon-based material, surface etching and nitrogen doping are carried out on the carbon-based material under the high-temperature condition, surface modification of the carbon-based material is achieved, the contact area of the surface of the carbon-based electrode and electrolyte is increased, and the electrochemical performance of the carbon-based electrode is improved.

The invention discloses an infrared shielding polyurethane glass film and a preparation method thereof, and relates to the technical field of high polymer materials. When the infrared shielding polyurethane glass film is prepared, an organic nickel complex and 3-imidazole-1-propionic acid react to prepare a functional cross-linking agent; the preparation method comprises the following steps: reacting 4-aminophenylacetonitrile with 3-hydroxypropyl acrylate and quinoline-4-formaldehyde in sequence to prepare an ultraviolet absorption monomer; the preparation method comprises the following steps: carrying out reaction polymerization on polypropylene glycol, an ultraviolet absorption monomer, 1, 4-butanediol and 4-chloromethyl-1, 3-phenyl diisocyanate to prepare polyurethane; the tungsten-doped titanium dioxide and chloropropyltriethoxysilane are subjected to a reaction, and modified titanium dioxide is prepared; uniformly mixing polyurethane, modified titanium dioxide, a functional cross-linking agent and acetone, and coating and curing to obtain the infrared shielding polyurethane glass film. The infrared shielding polyurethane glass film prepared by the invention has excellent infrared shielding, anti-aging, antibacterial and mechanical properties.

The present invention makes it possible to provide a solid electrolyte sheet to be used as a separator layer that separates a positive electrode layer from a negative electrode layer in an all-solid-state battery, the solid electrolyte sheet comprising a support base material and a boron cluster-type solid electrolyte. Furthermore, the present invention makes it possible to provide a method for producing a solid electrolyte sheet, the method comprising a step for preparing a solid electrolyte solution obtained by dissolving a boron cluster-type solid electrolyte in a solvent, and a step for obtaining a solid electrolyte sheet by applying the obtained solid electrolyte solution to a support base material and then drying the result, wherein the solvent contains at least one substance selected from the group consisting of water, alcohol-based solvents, tetrahydrofuran, acetonitrile, toluene, N-methylpyrrolidone, dimethyl carbonate, and ethyl acetate.

The invention provides a method for detecting taurine in magnesium acetyltaurate, which comprises the following steps: (1) derivatization treatment: carrying out derivatization reaction on a derivatization reagent and magnesium acetyltaurate containing taurine under an alkaline condition to obtain a derivatization product; (2) detection: detecting the derivatization product in the step (1) by adopting a high performance liquid chromatography-ultraviolet detector; wherein the derivatization reagent is selected from the group consisting of 2, 4-dinitrofluorobenzyl cyanide. The determination method has the advantages of high sensitivity, good specificity, simple operation, high accuracy, good reproducibility, good stability and low cost, improves the quality standard of taurine detection in magnesium acetyltaurate, can strictly control the quality of taurine in magnesium acetyltaurate, ensures the safety and reliability of magnesium acetyltaurate, and has a wide application prospect. The practical significance is realized.

The present invention relates to a hydroxyacetonitrile production method and production system based on a carbon fiber off-gas. The carbon fiber off-gas comprises a carbonization off-gas. The hydroxyacetonitrile production method comprises the following steps: subjecting the carbonization off-gas to de-tarring treatment and de-ammoniation treatment to obtain a treated off-gas; and performing a nucleophilic addition reaction between the treated off-gas and formaldehyde in the presence of a catalyst to obtain the hydroxyacetonitrile. By subjecting the carbonization off-gas to de-tarring treatment and de-ammoniation treatment and performing a nucleophilic addition reaction between the treated off-gas and formaldehyde in the presence of the catalyst to obtain the hydroxyacetonitrile, the present invention can significantly reduce the contents of hydrogen cyanide and ammonia gas in the off-gas, and the treated off-gas can meet emission standards. In addition, using the carbon fiber off-gas as a starting material to produce hydroxyacetonitrile can also be achieved, thereby leading to improved resource utilization rate and economic benefits.

The invention provides a construction method and application of a Kaixin powder substance-based characteristic chromatogram. The construction method comprises the following steps: acquiring a characteristic chromatogram of a to-be-detected substance by adopting ultra-high performance liquid chromatography; chromatographic conditions are as follows: octadecylsilane chemically bonded silica is used as a chromatographic column of a filler; acetonitrile is used as a mobile phase A, 0.025%-0.1% phosphoric acid aqueous solution is used as a mobile phase B, and elution is carried out according to a specific gradient program; the method comprises the following steps: respectively carrying out detection by using detection wavelengths of 198-208 nm and 315-325 nm, and switching the detection wavelength to 237-247 nm within t min when the detection wavelength of 315-325 nm is used for detection, and t is 100-110. The characteristic chromatogram obtained by the construction method comprises at least 52 characteristic peaks, the material information of the characteristic chromatogram is more comprehensive, and the construction method has important significance on the quality control of the Kaixin powder.

A spiral vibration drying device relates to the technical field of drying equipment, and comprises: a tank body, one side of the lower part of which is provided with a discharge port; the drying assembly is vertically arranged in the tank body, and the heat inlet end of the drying assembly penetrates out of the bottom of the tank body and is used for being connected with an external heat source; the vibration discharging assembly comprises a spiral discharging piece arranged on the outer side of the drying assembly in a sliding and sleeving mode and a vibration piece arranged at the bottom of the spiral discharging piece, the spiral discharging piece is arranged in the circumferential direction of the drying assembly from top to bottom, and the discharging end of the spiral discharging piece freely penetrates through the discharging port; the elastic supporting assembly is arranged between the spiral blanking piece and the inner wall of the bottom of the tank body; the anilinoacetonitrile is fully and uniformly dried through the drying assembly in the discharging process of the spiral discharging piece, the dried anilinoacetonitrile is discharged out of the tank body from the discharging opening, operation is easy and convenient, it is guaranteed that the anilinoacetonitrile can be continuously and stably dried, and the drying device has the good drying effect and drying reliability.

The invention provides a method suitable for industrial production of curcumin crystals, the method comprising: first extracting turmeric particles with ethyl acetate to obtain a turmeric crude extract, mixing the turmeric crude extract with an impurity remover, separating, concentrating the upper solvent under reduced pressure to obtain turmeric oil, concentrating the middle impurity layer under reduced pressure to obtain a polysaccharide substance, concentrating the lower layer under reduced pressure to obtain a turmeric extract, dissolving the turmeric extract in ethanol, removing the solvent, refining and drying to obtain a curcumin crystal with a purity higher than 96%, a residual solvent lower than 1000ppm, and a content yield higher than 83%. The process flow of the invention is short, there is no risk of adding an emulsifier and an acid-base substance, and secondary crystallization is not required. The obtained curcumin crystal product has a high content, and does not contain organic solvents harmful to the human body such as acetonitrile. The method of the invention is simple to operate, low in cost, and easy to control, and is suitable for industrial production.

The invention relates to a preparation method of aldehyde group functionalized halogen-containing helicene, which comprises the following steps: S1, dissolving terephthalaldehyde and p-halobenzyl cyanide in ethanol, adding sodium ethoxide into the solution for reaction, and washing, filtering and drying a reaction product to obtain a solid A; s2, dissolving the solid A in methylbenzene, then adding iodine and epoxypropane for reaction, and washing, filtering and drying a reaction product to obtain a solid B; s3, dissolving the solid B in dichloromethane, adding n-butyllithium into the dichloromethane, sequentially and slowly adding methanol, water and hydrochloric acid after the color of the solution is changed, extracting an organic filtrate after the reaction is completed, carrying out rotary evaporation on the organic filtrate, washing, filtering and drying to obtain aldehyde group functionalized halogen-containing helicene; the invention provides the aldehyde group functionalized halogen-containing helicene and the preparation method thereof, the method is simple to operate, the reaction is simple and convenient, the expansion is flexible, the aldehyde group is successfully introduced into the compound, the reaction steps are reduced, and the experiment complexity is reduced.

The invention discloses a preparation method of a Lamellarin key intermediate, which comprises the following steps: in the presence of a solvent and at 70-150 DEG C, carrying out reaction on 5, 6-dihydro-1, 2-diphenylpyrrolo [2, 1-a] isoquinoline or a derivative thereof, benzyl cyanide and a copper compound to prepare the Lamellarin key intermediate; the method is low in cost, raw materials are easy to obtain, reaction conditions are mild, reaction yield is high, purity is high, the process is simple and easy to implement and relatively environmentally friendly, the method is suitable for industrial production, related products are prepared for the fields of biology, pesticide and medicine, and the Lamellarin compound which is abundant in source and low in price is provided; .

The invention belongs to the technical field of pharmaceutical analysis, and provides a method for detecting related impurities of EvoCASE, which comprises the following steps: precisely weighing EvoCASE, and diluting with a mobile phase A as a solvent to obtain a test solution; precisely measuring the test solution obtained in the step S1, and diluting with the mobile phase A as a solvent to obtain a contrast solution; weighing evocamide and various impurity reference substances, and diluting by taking the mobile phase A as a solvent to obtain a system applicable solution; carrying out liquid chromatography detection, and calculating the content of each impurity in the to-be-detected EvoCassette; chromatographic conditions are as follows: a chromatographic column adopts octadecylsilane chemically bonded silica as a filler; the mobile phase A and the mobile phase B are mixed liquid of buffer salt, methanol and acetonitrile. The method provided by the invention can be used for simultaneously separating and detecting various impurities in the Evocamide, has the characteristics of simplicity in operation and high sensitivity, is high in chromatographic peak separation degree, does not interfere with each other, is good in peak shape, can be used for detecting related impurities in the Evocamide and a preparation thereof, and ensures the medication safety of the Evocamide and the preparation thereof.

The invention relates to a CDK drug intermediate 3-(3-bromophenyl) piperidine-2, 6-diketone as well as a synthesis method and application thereof, and belongs to the technical field of medicine synthesis. The synthetic method of the CDK drug intermediate 3-(3-bromophenyl) piperidine-2, 6-diketone provided by the invention comprises the following steps: (1) mixing 3-bromobenzyl cyanide and acrylonitrile, slowly dropwise adding benzyltrimethylammonium hydroxide, and refluxing to obtain an intermediate 2-(3-bromophenyl) glutaronitrile; and (2) dissolving the intermediate 2-(3-bromophenyl) glutaronitrile in an acetic acid-concentrated sulfuric acid solution, and carrying out hydrolysis cyclization to obtain the target compound 3-(3-bromophenyl) piperidine-2, 6-diketone. According to the invention, 3-bromophenylacetonitrile is used as an initial raw material, and a target product is prepared only through two simple steps. The method has the advantages of easily available raw materials, short reaction route, simple post-treatment and the like, and is suitable for industrial preparation and production.

The invention provides a liquid chromatography detection method and a quantitative determination method for volatile carbonyl compounds in cigarette smoke. The liquid chromatography detection method is based on a DNPH compound special chromatographic column and gradient elution, adopts a mobile phase composed of water and acetonitrile in a volume ratio of 1: 1-1: 9, and realizes the determination of n-butyraldehyde and isobutyraldehyde in the cigarette smoke as well as the determination of n-butyraldehyde and isobutyraldehyde and other 7 carbonyl compounds required to be determined in ISO 21160 and YC / T 254-2008 standards for the first time. The volatile carbonyl compounds such as formaldehyde, acetaldehyde, acetone, acrolein, propionaldehyde, crotonaldehyde, 2-butanone and the like are effectively separated, and the effective separation of the volatile carbonyl compounds and other interferents in the smoke is further realized. The invention further provides a quantitative determination method for volatile carbonyl compounds in cigarette smoke, a liquid chromatography-ultraviolet analysis method is adopted, the liquid chromatography is the liquid chromatography detection method, and the accuracy and reliability of the quantitative determination result are remarkably improved.

The utility model discloses a reaction device which comprises a waste water tank, the output end of the wastewater tank is connected with the cyanogen breaking kettle and is used for conveying cyanogen-containing waste liquid; a first pump body is arranged at the output end of the cyanogen breaking kettle, and the output end of the first pump body is connected with the top of the cyanogen breaking kettle and a neutralization kettle; a second pump body is arranged at the output end of the neutralization kettle, and the output end of the second pump body is connected with the top of the neutralization kettle and a saline water tank; the cyanogen breaking kettle, the neutralization kettle and the wastewater tank are matched for use, a first pump body and a second pump body are utilized for circulation in the cyanogen breaking and neutralization process, full reaction is achieved, the total cyanogen content of cyanogen-containing wastewater obtained through cyanidation synthesis of o-chlorobenzyl cyanide can be reduced to 20 mg / kg, and meanwhile the pH value of saline water is close to alkalescence.

This invention relates to a method for synthesizing azoxystrobin, belonging to the field of organic synthesis technology. The method uses 2-(2-(chloromethyl)phenyl)-3-methoxyacrylonitrile and 2-hydroxy-6-trifluoromethylpyridine as raw materials, condensing them under alkaline conditions to obtain an etherified intermediate, which is then directly hydrolyzed and esterified with methanol under acidic conditions to obtain azoxystrobin. This method avoids the use of expensive 3-isochloroketone as a raw material, using inexpensive 2-(2-(chloromethyl)phenyl)-3-methoxyacrylonitrile prepared from o-methylphenylacetonitrile as the key fragment, further reducing the cost of azoxystrobin raw materials. Furthermore, the process route is simple, the yield is high, and it is suitable for industrial production.

The invention discloses a method for preparing 2, 6-dichloro-alpha-(4-chlorophenyl)-4-nitrophenylacetonitrile, which comprises the following steps: S1, synthesizing 2, 6-dichloro-alpha-(4-chlorophenyl)-4-nitrophenylacetonitrile: reacting phenylacetonitrile with chlorine under the action of a chlorination catalyst; the 2, 6-dichlorobenzyl cyanide is obtained; s2, introducing a 4-chlorophenyl group: carrying out a cross-coupling reaction on the 2, 6-dichlorobenzyl cyanide obtained in the step 1 and 4-chlorophenylboronic acid or 4-chlorophenyl lithium in a solvent; and S3, introducing a nitro group into the intermediate obtained in the step 2. Carrying out nitration reaction on the intermediate and nitric acid under the catalytic action of sulfuric acid; and S4, purification: purifying the final product through a conventional separation and purification technology. The synthesis method provided by the invention has high reaction yield, can effectively reduce the waste of raw materials, improves the yield of the product, not only can reduce the production cost, but also can reduce the pollution to the environment, and has high economic and environmental benefits.

The present invention provides a nonaqueous electrolyte solution for a nonaqueous lithium ion secondary battery that is provided with a negative electrode containing graphite, while comprising a nonaqueous electrolyte solution in an amount of X mass % relative to the mass of the negative electrode excluding the negative electrode collector, wherein X is 50 to 2,000. This nonaqueous electrolyte solution contains a lithium salt and a nonaqueous solvent; acetonitrile is contained as the nonaqueous solvent in an amount of A volume % relative to the volume of the nonaqueous solvent, wherein A is 5 to 70; the nonaqueous electrolyte solution contains vinylene carbonate (VC) as an additive; and the content of VC is (7×A / X) mass % to 10 mass % relative to the nonaqueous electrolyte solution.

Disclosed are an α-cyanodiarylethene fluorescent material for light-controlled nitric oxide release, as well as its preparation and application. The preparation method comprises the following steps: first reacting 4-(dimethylamino)benzaldehyde and tert-butyl nitrite under the action of a catalyst to generate a compound, and then reacting the resulting compound with arylacetonitrile under the action of a base to obtain the α-cyanodiarylethene fluorescent material for light-controlled nitric oxide release. The material, as a nitric oxide donor, can release nitric oxide under illumination, and has aggregation-induced luminescence properties, with a large change in the molecular emission wavelength before and after nitric oxide release. Nitric oxide release can be precisely controlled according to changes in illumination power and time. The molecular nitric oxide release behavior can be detected by changes in the molecular fluorescence signal. The material has the characteristics of a large Stokes shift, controllable nitric oxide release, and unquenched fluorescence in an aggregated state, and can achieve in vivo calibration of nitric oxide release by utilizing changes in emission wavelength and fluorescence intensity.

This invention discloses a method for synthesizing organophosphonic fluoride compounds. The method involves fluorinating organophosphonic oxides with fluorinating agents such as copper tetraacetonitrile hexafluorophosphate or copper tetraacetonitrile tetrafluoroborate to obtain organophosphonic fluoride compounds. The fluorinating agents used in this synthesis method are inexpensive, readily available, and stable, avoiding the use of expensive and unstable fluorinating agents. Furthermore, it enables efficient and selective conversion of organophosphonic oxides to organophosphonic fluoride compounds under mild conditions, and exhibits a wide range of functional group tolerances.

The invention relates to a preparation method of ketoprofen, and belongs to the technical field of synthesis of drug intermediates. In order to solve the problems of low yield and difficulty in removing impurities in the prior art, the invention provides a preparation method of ketoprofen, which comprises the following steps: in the presence of alkali metal alkoxide, reacting 3-benzoylbenzyl cyanide with a methyl esterification reagent to obtain a compound as shown in a formula II; carrying out methylation reaction on the compound as shown in the formula II and dimethyl sulfate; carrying out selective ester hydrolysis reaction under the action of an ester hydrolysis catalyst to obtain salt of a compound as shown in a formula IV; after the reaction is finished, enabling a reaction solution to contain water and a water-insoluble organic solvent, standing for layering, collecting a water phase, and adding acid into the water phase for acidification to obtain a compound shown as a formula IV; and under acidic or alkaline conditions, carrying out cyano hydrolysis and decarboxylation reaction on the compound as shown in the formula IV to obtain ketoprofen. Through route improvement, the product purity is more effectively guaranteed, and the effects of high product purity and yield are achieved.

The invention discloses a high performance liquid detection method for purity of (1S, 4R)-4-amino-2-cyclopentene-1-methanol hydrochloride, which comprises the following steps of: preparing a solution sample by adopting a chromatographic column taking octadecylsilane chemically bonded silica as a filling agent and taking acetonitrile-a buffer solution containing 50mmoL / L sodium dihydrogen phosphate and 10mmoL / L sodium octanesulfonate in a volume ratio of (13: 87)-(17: 83) as a mobile phase; and calculating the purity of the sample according to a peak area normalization method. The method can effectively separate each component in a short time, and has the characteristics of simplicity and convenience in operation, high analysis efficiency and stable result.

The invention belongs to the technical field of chemical synthesis, and particularly relates to a preparation method of triazolone-14C. Comprising the following steps: synthesizing phenol-14C: preparing a system A: adding water and concentrated sulfuric acid into a single-mouth bottle and stirring; performing liquid separation on aniline hydrochloride-14C and a saturated sodium bicarbonate solution, performing extraction, adding an organic phase into the system A, performing reaction concentration, dropwise adding sodium nitrite, adding methylbenzene, and performing reaction at 100 DEG C; extracting, drying, filtering, concentrating, and passing through a chromatographic column; the preparation method comprises the following steps: synthesizing 4-chlorophenol-14C, namely dropwise adding N-chlorosuccinimide into 4-chlorophenol-14C, p-toluenesulfonic acid and acetonitrile, and reacting completely; extracting, drying, filtering, concentrating, and passing through a chromatographic column; 4-chlorophenol-14C, ethyl acetate, 1, 2, 4-triazole, potassium carbonate and 600 polyethylene glycol are synthesized, 1, 1-dichloropinacolone is dropwise added, and a reaction is conducted at the temperature of 85 DEG C; after the reaction is finished, cooling to room temperature, extracting, drying, filtering, concentrating, and passing through a chromatographic column; the total yield of the three steps is basically maintained between 60% and 85%, the synthetic reaction conditions are simple, and the yield is high.

The invention belongs to the technical field of organic polymer materials, and discloses a diamine monomer containing an acrylonitrile structure and black polyimide synthesized by the diamine monomer. The black diamine monomer containing the acrylonitrile structure is synthesized by taking a monomer containing a benzyl cyanide structure and a monomer containing a benzaldehyde structure as raw materials. And carrying out polycondensation on the synthesized diamine monomer (added with other diamines) and a dianhydride monomer to obtain a polyamide acid solution, and preparing the black polyimide by a thermal method or a chemical imine method. The diamine monomer containing the acrylonitrile structure with the large-plane conjugated structure and the light absorption effect is used for preparing the intrinsic black polyimide, the method is simple and efficient, and the black polyimide can be prepared without adding or coating any black substance. The prepared black polyimide is excellent in shading performance and heat resistance and has wide application value in the fields of electronic industry, aerospace, instrument communication and the like.

The invention belongs to the technical field of pesticide mite killing, and discloses a mite killing composition and application thereof, the mite killing composition comprises an active component A and an active component B, the active component A is a compound as shown in a formula I: # imgabs0; the active component B is selected from a group consisting of a B1 heterocyclic acaricide, a B2 tetronic acid acaricide, a B3 benzoylacetonitrile acaricide, a B4 acrylonitrile acaricide, a B5 oxazole acaricide, a B6 pyrazole amide acaricide, a B7 biphenylhydrazine acaricide, a B8 antibiotic acaricide, a B9 organic tin acaricide and a B10 tetrazine acaricide; b11 thiazolidinone acaricides, and the like. The acaricidal composition disclosed by the invention is obvious in synergism, has a relatively good prevention and treatment effect on common tetranychidae pest mites of crops, and can effectively control the harm of mite pests, reduce the use dosage of pesticides and reduce the agricultural production cost.

The utility model discloses an ammonolysis reaction kettle for producing o-chlorobenzyl cyanide, which comprises a kettle body, a separation seat, an electromagnetic blanking assembly and a stirring assembly, and a kettle cover is fixed at the top of the kettle body through bolts and nuts; a temperature control jacket is arranged outside the kettle body; a first feeding flange and a second feeding flange are arranged on the kettle cover; the partition seat comprises a conical bin, an outer edge is integrally formed on the top surface of the conical bin, a plurality of through holes are formed in the outer edge at intervals, the outer edge is pressed and sealed by the kettle body and the kettle cover, and the bolts movably penetrate through the through holes; a feeding embedded opening is formed in the upper portion of the conical bin. A shaft penetrating through hole is formed in the center of the conical bin; the conical bin is provided with a plurality of assistant blanking ports outside the shaft penetrating through hole; according to the ammonolysis reaction kettle for producing the o-chlorobenzyl cyanide, disclosed by the utility model, a catalyst is fed into the kettle body in a dynamic adding manner and participates in ammonolysis reaction; temperature fluctuation is not caused in the feeding process, and the catalyst is not precipitated at the bottom of the kettle body.

The invention discloses a method for determining the content of formaldehyde in a hydrochlorothiazide bulk drug, which comprises the following steps: precisely weighing a formaldehyde solution, adding acetonitrile, an acetonitrile solution of 2, 4-dinitrophenylhydrazine and a phosphoric acid solution, and diluting to prepare a reference substance solution; the method comprises the following steps: precisely weighing a hydrochlorothiazide bulk drug, adding acetonitrile, an acetonitrile solution of 2, 4-dinitrophenylhydrazine and a phosphoric acid solution, and diluting to prepare a test solution; the method comprises the following steps: precisely measuring an acetonitrile solution of 2, 4-dinitrophenylhydrazine, a phosphoric acid solution and 1ml of acetonitrile, and diluting with acetonitrile to prepare a blank solution; analyzing by adopting high performance liquid chromatography, precisely measuring the blank solution, the test solution and the reference substance solution, respectively injecting into a liquid chromatograph, recording chromatograms, and calculating by peak area according to an external standard method to obtain the content of formaldehyde in the hydrochlorothiazide bulk drug. The method has the remarkable effects that the method has the characteristics of simple process, low use cost, good precision, high accuracy and the like, and the content of formaldehyde in the hydrochlorothiazide bulk drug can be rapidly measured.

The present invention relates to crystalline forms of a KRas G12C inhibitor and salt thereof. In particular, the present invention relates to crystalline forms of the KRas G12C inhibitor 2-[(2S)-4-[7-(8-chloro-1-naphthyl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoroprop-2-enoyl)piperazin-2-yl]acetonitrile, pharmaceutical compositions comprising the crystalline forms, processes for preparing the crystalline forms and methods of use thereof.

The invention discloses a high performance liquid chromatography method for detecting related substances in a tandospirone citrate bulk drug. According to the method, a chromatographic column is an octadecyl silane bonded silica gel packed column; the mobile phase A is a mixed solution of a buffer system with the pH value of 2.5-4.5 and acetonitrile, the mobile phase B is a mixed solution of a buffer system with the pH value of 1.5-3.0 and acetonitrile, gradient elution is adopted, dual-wavelength detection can be adopted, the first detection wavelength is 220-250 nm, and the second detection wavelength is 190-215 nm. The method can simultaneously separate and detect various related substances in the bulk drug, has the characteristics of strong specificity, high sensitivity, good repeatability, simplicity and convenience in operation and the like, and can be used for quality control of the tandospirone citrate bulk drug.