142 results about "Stokes shift" patented technology

The invention discloses a high-efficiency near-infrared two-region aggregation-induced emission material, a preparation method thereof and application of the high-efficiency near-infrared two-region aggregation-induced emission material in bimodal surgical navigation. According to the molecular structure, the organic near-infrared two-region material with an intramolecular charge transfer characteristic is constructed by taking thionaphthalene tetracarboxylic acid diimide as an electron acceptor group and tetraphenylethylene as a molecular rotor and an electron donor unit. By expanding the length of a pi conjugate fragment and introducing an isotope effect, the oscillator strength can be improved, and high-frequency vibration can be inhibited, so that the radiative transition rate of molecules is promoted, and the non-radiative transition rate is inhibited. The nanoparticles prepared from the aggregation-induced emission material have the advantages of high brightness, large Stokes shift and good light stability, and have an excellent effect in bimodal imaging guided mouse in-situ breast cancer and sentinel lymph node operation excision.

The invention belongs to the technical field of organic radiation luminescence and radiation imaging, and discloses an aggregation-induced delayed fluorescence (AIDF) type organic scintillator material and a preparation method thereof, and a preparation method and application of a flexible organic scintillation film. The molecular structure of the material comprises carbonyl, methylene, sulfuryl and other connecting units, phthalonitrile is used as an acceptor unit, carbazole is used as a donor unit, an aggregation-induced excitation state is formed through space charge transfer among molecules, efficient AIDF luminescence and large Stokes shift characteristics are realized, the self-absorption phenomenon is effectively avoided, and the luminescent efficiency is improved. The X-ray fluorescence probe is suitable for a luminescence process under an X-ray excitation condition, the sensitivity of X-ray detection is remarkably improved, and the lowest detection limit can reach 276nGy.s <-1 > and is far superior to the 5.5 mu Gy.s <-1 > standard required by medical diagnosis. Besides, the flexible scintillator film prepared based on the material system radiates and emits light within the waveband range of 450-750 nm and is perfectly matched with the response area of a silicon-based detector, X-ray imaging with the high signal-to-noise ratio is achieved, and the imaging resolution is as high as 20.01 lp.mm <-1 >.

The invention discloses an environment-sensitive fluorescent probe for detecting human serum albumin (HSA) as well as a preparation method and an application of the environment-sensitive fluorescent probe. According to the technical scheme adopted by the invention, a fluorescent probe formula 1 is designed and synthesized based on a dinitrile isophorone electron withdrawing group, the probe molecule is extremely sensitive to a microenvironment, and the fluorescence spectrum is obviously changed along with the change of the polarity and the viscosity of a solvent. In a mixed system of Tris-HCl and water, a probe and HSA are added, fluorescence is enhanced, and the concentration of HSA can be detected by using the change of fluorescence intensity. The fluorescent probe disclosed by the invention is simple to synthesize, large in Stokes shift, long in emission wavelength, sensitive to microenvironment, good in HSA detection selectivity, high in sensitivity and wide in linear range.

The invention relates to the technical field of organic functional materials, in particular to a near-infrared second-region cyanine dye molecule as well as a preparation method and application thereof, the structural formula of the near-infrared second-region cyanine dye molecule is shown as a formula I or a formula II: # imgabs0 #, the cyanine dye molecule is modified by benzopyranium, the excitation wavelength and the fluorescence emission wavelength of the near-infrared second-region cyanine dye molecule both reach the near-infrared second region, and the near-infrared second-region cyanine dye molecule is a near-infrared second-region cyanine dye molecule. Strong absorption and emission are shown in a near-infrared second region, and the Stokes shift is greater than 50nm; the synthetic method of the fluorescent dye is simple, raw materials are easy to obtain, and the yield is high; the cyanine dye disclosed by the invention is excellent in photo-thermal stability and good in photo-thermal imaging effect, has a good phototherapy effect and has a great potential application prospect in the field of tumor treatment.

The invention discloses a multiplex fluorescence immunohistochemical staining kit and application thereof. The multiplex fluorescence immunohistochemical staining kit comprises a plurality of casein amide substrate fluorescent dyes; the multi-tyramine substrate fluorescent dye comprises an aggregation-induced emission tyramine substrate and at least one narrow-spectrum tyramine substrate, the Stokes shift of the aggregation-induced emission tyramine substrate is larger than or equal to 150 nm, and the Stokes shift of the narrow-spectrum tyramine substrate is smaller than or equal to 60 nm. The full width at half maximum of the emission spectrum of the narrow-spectrum caseinate substrates is less than or equal to 50nm, and if the number of the narrow-spectrum caseinate substrates is more than or equal to two, the difference value of the maximum excitation wavelengths of any two narrow-spectrum caseinate substrates is more than or equal to 30nm. According to the present invention, the aggregation-induced emission tyrosine amide substrate with the large Stokes shift is used for the multiple fluorescence immunohistochemical staining, such that the staining multiple number is effectively improved, and the spectrum cross color does not occur;

A method for synthesizing carbon quantum dots (CQDs) including reacting a mixture of macroalgae and ethanol hydrothermally in an autoclave at a reaction temperature between 150 degrees Celsius (° C.) and 250° C. to form a suspension. The method further includes separating the CQDs from the suspension. The CQDs have a size of 1 to 5 nanometers (nm). The CQDs have a Stokes shift of at least 80 nm at an excitation wavelength of 270-410 nm.

A preparation method of an indium phosphide quantum dot (InP QD) with a large Stokes shift includes: fully dissolving the indium precursor at a first temperature under isolation from oxygen and water, adding a phosphorus precursor, and heating to a second temperature to allow a reaction to obtain an indium phosphide (InP) core; adding a shell precursor to the InP core, and heating to a third temperature to obtain QD with a core-shell structure; and adding anionic and cationic precursors successively to the QD with the core-shell structure at the third temperature to obtain the InP QD with an emission peak adjustable in a range of 465 nm to 650 nm, a high quantum efficiency, and a large Stokes shift. The InP QD mainly has a large Stokes shift to inhibit self-absorption and non-radiative resonance energy transfer.

A method for synthesizing carbon quantum dots (CQDs) including reacting a mixture of macroalgae and ethanol hydrothermally in an autoclave at a reaction temperature between 150 degrees Celsius (° C.) and 250° C. to form a suspension. The method further includes separating the CQDs from the suspension. The CQDs have a size of 1 to 5 nanometers (nm). The CQDs have a Stokes shift of at least 80 nm at an excitation wavelength of 270-410 nm.

The invention discloses a donor-receptor porphyrin molecular engineering-based high-sensitivity hypochlorous acid fluorescent probe and a synthesis method thereof, the structural formula of the probe is as follows: # imgabs0 #, the probe can detect hypochlorous acid (HClO) with high sensitivity, phenothiazine groups are introduced at two meso positions of porphyrin, and a donor-receptor (D-A) system is formed in molecules. The probe has rapid response performance to hypochlorous acid, sulfur atoms in phenothiazine are oxidized through hypochlorous acid, phenothiazine electrons are prevented from being transferred to porphyrin under light excitation, and therefore red fluorescence is shown, and selective detection of hypochlorous acid is achieved. After the probe reacts with hypochlorous acid, 667 nm red fluorescence is emitted under the excitation wavelength of 450 nm, the fluorescence appears obviously, and the Stokes shift is 217 nm. The reaction product has the advantages of good water solubility, high fluorescence quantum yield, large Stokes shift and the like. The probe can detect hypochlorous acid with high sensitivity, and has a huge application prospect in the technical fields of analytical chemistry, life science, environment detection, biomedical treatment and the like.

A method for synthesizing carbon quantum dots (CQDs) including reacting a mixture of macroalgae and ethanol hydrothermally in an autoclave at a reaction temperature between 150 degrees Celsius (° C.) and 250° C. to form a suspension. The method further includes separating the CQDs from the suspension. The CQDs have a size of 1 to 5 nanometers (nm). The CQDs have a Stokes shift of at least 80 nm at an excitation wavelength of 270-410 nm.

The invention discloses a multi-cyano offset substituted pentamethine cyanine dye and a synthesis method and application thereof, and the dye has the following general formula structure: # imgabs0. According to the multi-cyano offset substituted pentamethine cyanine dye disclosed by the invention, the absorption emission wavelength is increased by introducing an offset substitution structure; the dye has near-infrared first-area imaging and treatment performance, so that the optimal excitation and emission wavelength can be flexibly selected, the dye shows obvious Stokes shift, reduction of self-absorption and scattering effects is facilitated, the imaging definition and depth are improved, the molar extinction coefficient of the prepared dye is up to 190000, and the dye can be applied to near-infrared first-area imaging and treatment of the near-infrared first-area imaging and treatment of the near-infrared first-area imaging and treatment of the near-infrared first-area imaging. According to the present invention, with the application of the dye, the light energy utilization degree of the dye is substantially improved, the long wavelength light with the deeper penetration depth can be strongly absorbed, the light energy capture and conversion can be effectively achieved, the photosensitizer efficiency can be improved, the light dose can be reduced, the phototoxicity can be reduced, the high absolute fluorescence quantum yield can be represented, and the biological imaging effect can be substantially improved; and the imaging quality is higher.

The invention discloses a near-infrared fluorescent probe based on a xanthene-quinoline conjugated skeleton for detecting Cu < 2 + > as well as a preparation method and bioimaging application of the near-infrared fluorescent probe. The molecular formula of the fluorescent probe is C34H32N4O2. Based on the strategy of inhibiting the PET process, the large Stokes shift near-infrared fluorescent probe for specifically recognizing Cu < 2 + > is constructed, and spectrum experiments show that the probe has excellent recognition performance on Cu < 2 + >, the emission wavelength is 720 nm, and the Stokes shift reaches 170 nm; (2) the specificity is high, and Cu < 2 + > and other biological related metal ions can be effectively distinguished; (3) low detection limit (LOD = 17.6 nM); (4) quick response dynamics (lt; 30s) for a motor vehicle. More importantly, the probe XQ-NH2 is successfully applied to Cu < 2 + > imaging in living cells and living mice, it is proved that XQ-NH2 not only can provide a reliable technical means for Cu < 2 + > detection and imaging research in a complex biological system, but also shows that XQ-NH2 has important application potential in related fields.

The invention relates to an azaazulene-containing large conjugated heteroaryl complex and a preparation method and application thereof, and the method comprises the following steps: mixing an azaazulene precursor and a benzene precursor, carrying out a coupling reaction, mixing an azaazulene intermediate obtained by the coupling reaction with a coordination center, and carrying out a coordination reaction to obtain the azaazulene-containing large conjugated heteroaryl complex. The azaazulene-containing large conjugate heteroaryl complex is obtained. Compared with the prior art, the invention has the characteristics of large molar absorption coefficient, large Stokes shift and large red shift of absorption emission peak, and shows bright fluorescence characteristic.

The present invention provides a large Stokes shift near-infrared fluorescent probe for detecting HClO, its preparation method and biological imaging application, belonging to the field of bioanalysis technology. Based on the strategy of modifying the substituents at the 3,6 positions of xanthene, the present invention constructs a large Stokes shift near-infrared fluorescent probe for specifically recognizing HClO. Optical experiments show that the emission wavelength of the probe for detecting HClO is 776 nm, the Stokes shift reaches 148 nm, with strong selectivity, high sensitivity, and a detection limit as low as 4.95 nM, which can greatly reduce the interference of background fluorescence in biological imaging applications. The fluorescent probe of the present invention has almost no cytotoxicity and can be applied to the detection and imaging of HClO in living cells MCF-7 and rat liver tissues, with a tissue penetration depth of 140 μm.

The present invention relates to the technical field of luminescent materials and preparation methods thereof, and discloses a broadband white light cluster and a preparation method thereof. The broadband white light cluster has the general chemical formula: x Cu y I z αH2O, where A comprises at least one alkylamine. The broadband white-light cluster luminescent material of the present invention has an excitation peak in the ultraviolet region, making it well compatible with commercial UV chips. Its emission peak width covers 400-800nm. Its large Stokes shift (150nm) effectively prevents reabsorption. By controlling the pressure within which the broadband white-light cluster luminescent material is exposed, the present invention achieves luminescence enhancement and spectral control. The broadband white-light cluster luminescent material of the present invention utilizes inexpensive raw materials, has a simple synthesis process, operates at a low temperature, and exhibits stable chemical properties and is pollution-free, making it suitable for large-scale production.

The application provides a semiconductor laser element with a topological phonon state layer, comprising, from bottom to top, a substrate, a lower limiting layer, a lower waveguide layer, an active layer, an upper waveguide layer and an upper limiting layer. The application is characterized in that a topological phonon state layer with a multilayer structure is arranged between the lower waveguide layer and the lower limiting layer of the semiconductor laser element, and the saturation electron drift velocity distribution characteristics, the electron affinity energy distribution characteristics and the polarized optical phonon energy distribution characteristics of each layer of the topological phonon state layer are designed, so that the topological quantum state and the topological phase change of the phonon spectrum can be adjusted, the quantum state and the lattice vibration mode can be changed, the Stokes shift loss of the difference between the photon energy of the pump light and the oscillation light can be reduced, and the thermal stress and the temperature quenching problem of the laser can be inhibited.

This invention relates to ONOO ‑ In the field of detection technology, specifically involving an ONOO ‑ Near-infrared fluorescent probe, its preparation method, and its application. This invention constructs a novel fluorescent probe specifically for detecting ONOO. ‑ The ONOO ‑ Near-infrared fluorescent probe for ONOO ‑ It exhibits good reactivity and is capable of specifically imaging endogenous ONOO in living cells or in vivo systems. ‑ Furthermore, it exhibits a large Stokes shift and an emission wavelength of 760 nm, significantly higher than other near-infrared fluorescent probes based on hemicyanine dye structures. In addition, this ONOO... ‑ The near-infrared emission characteristics of near-infrared fluorescent probes enable them to penetrate deeper into tissues and reduce background interference in bioimaging, which is significant for improving imaging sensitivity and accuracy. Based on these characteristics, ONOO... ‑ Near-infrared fluorescent probes can be used for the diagnosis and research of diseases such as atherosclerosis, neurodegenerative diseases, inflammation, and cancer.

The invention discloses a benzothiazole compound as well as a preparation method and application thereof. The compound has a structure as shown in a formula I. The invention provides a series of benzothiazole compounds with novel structures. The compound has an aggregation-induced emission property; the emission reaches near-infrared region emission from conventional short wavelength; the fluorescent probe has the characteristics of large Stokes displacement, long emission wavelength and high fluorescence quantum yield.

The invention discloses an indium phosphide quantum dot with a large Stokes shift and a preparation method thereof, and relates to the technical field of quantum dot materials. The preparation method comprises: isolating an indium precursor from oxygen and water at a first temperature, fully dissolving it, adding a phosphorus precursor and then raising the temperature to a second temperature to react, obtaining an indium phosphide core, then adding a shell precursor, raising the temperature to a third temperature, obtaining a quantum dot of a core-shell structure, and then sequentially adding anion and cation precursors at the third temperature to obtain a quantum dot with an emission peak adjustable between 465 and 650 nm, high quantum efficiency and a large Stokes shift. The quantum dot mainly has a large Stokes shift to suppress self-absorption and non-radiative resonant energy transfer, a wide bandgap shell can effectively passivate surface defects, achieve a high fluorescence quantum efficiency, and the position of the fluorescence emission peak can be adjusted in the visible light range by changing the activity of the precursor, does not contain heavy metal elements such as cadmium and lead, and is relatively friendly to the environment.

The application discloses a beta-galactosidase near-infrared fluorescent probe with a large stokes shift and a preparation method and application thereof. The structure of CPD-gal is shown in formula I. When a 580nm excitation wavelength is used for excitation, CPD-gal has weak fluorescence at 713nm, but can selectively undergo a fluorescence opening reaction with beta-gal. With the increase of the concentration of beta-gal, the fluorescence intensity at 713nm is gradually enhanced, and other interfering ions and species will not interfere with the detection of beta-gal by CPD-gal. Since the emission wavelength is in the near-infrared region and a large stokes shift is generated, the system background fluorescence interference is greatly reduced, and the sensitivity of the detection of beta-gal is improved. Therefore, CPD-gal is suitable for the fluorescence detection of beta-gal with high selectivity and high sensitivity. The probe is successfully applied to the fluorescence imaging of endogenous beta-gal in HeLa cells and SK-OV-3 cells.

The present invention provides a frequency up-conversion xanthene fluorescent dye and a preparation method thereof and an application in biological fluorescence labeling, belonging to the field of biological optical labeling technology. The frequency up-conversion xanthene fluorescent dye provided by the present invention uses xanthene as a parent, and the xanthene structure is connected to the nitrogen heterocycle of indole, has frequency up-conversion luminescence performance, can not only realize near-infrared emission, but also realize short-wavelength luminescence ability under anti-Stokes shift long wavelength (730nm) excitation, can enter cells in a short time to realize fluorescent staining, and can realize schistosome fluorescent labeling imaging. At the same time, the excitation conditions of the up-conversion luminescence of the frequency up-conversion xanthene fluorescent dye provided by the present invention are mild, which can reduce the thermal effect or light damage caused by the excitation light, thereby avoiding the problems of short wavelength and high power excitation existing in traditional organic fluorescent dyes.

The invention relates to the technical field of laser elements, and discloses a laser element with an excitation transfer emission mechanism, which comprises a substrate, a lower limiting layer, a lower wave layer, an active layer, an upper waveguide layer, an electron blocking layer and an upper limiting layer which are sequentially arranged from bottom to top, an Auger auxiliary light emission layer disposed between the active layer and the upper waveguide layer and between the active layer and the lower waveguide layer; wherein the Auger auxiliary light emission layer has a spin exchange Auger type excitation transfer emission mechanism, and the spin exchange transfer rate exceeds 1012s <-1 >. The auxiliary light emission layer with a spin exchange auger type excitation transfer emission mechanism is introduced between the active layer and the waveguide layer of the laser element, so that stokes frequency shift loss can be effectively inhibited, the coupling efficiency from a pumping energy level to a laser energy level is improved, stimulated radiation of the laser element is enhanced, an excitation threshold value is reduced, and the laser element has a good application prospect. Energy loss and waste heat are reduced, temperature distribution uniformity is improved, and the problem of uneven distribution of thermal expansion and thermal stress is relieved.

The application discloses a device and method for detecting energy carrier dissipation behavior in thermal insulation materials, which comprises: a laser emission module for emitting a laser beam; a first filter for separating the laser beam; a supercontinuum beam forming device for processing the second laser beam; a phase delay line for phase delaying the first laser beam; the wavelength range of the supercontinuum beam is wider than that of the pump beam; a second filter for combining the supercontinuum beam and the pump beam, and then irradiating the surface of the sample and being transmitted by the sample; a photodetector collects the transmitted beam; a controller controls the delay time change of the phase delay line once, receives the transmitted beam once, processes each transmitted beam, obtains the corresponding time-resolved broadband spectral coherent anti-Stokes shift, and extracts the longitudinal optical phonon dephasing process of the sample according to the anti-Stokes shift. Multimodal coherent phonon detection of the sample is realized.

The invention belongs to the technical field of photosensitive materials, and particularly relates to an aggregation-induced emission type photosensitizer as well as a preparation method and application thereof. The aggregation-induced emission type photosensitizer provided by the invention has a structure as shown in any one of formulas I-III. The aggregation-induced emission (AIE) photosensitizer has large Stokes shift, can emit light in a near infrared region I (NIR-I), and is beneficial to penetrating deep biological tissues and reducing light damage to the biological tissues; meanwhile, the AIE type photosensitizer has relatively strong I type active oxygen generation capability, and is expected to be used as a photosensitizer for photodynamic therapy. Formula I, Formula II and Formula III.

The invention relates to the field of fluorescent dyes, in particular to a near-infrared fluorescent dye for brain imaging as well as a preparation method and application of the near-infrared fluorescent dye. The near-infrared fluorescent dye for brain imaging has the advantages of novel structure, good biocompatibility, large Stokes shift, high light stability, high fluorescence signal-to-noise ratio and the like; the near-infrared fluorescent dye prepared by the invention is simple in preparation process, mild in reaction condition, short in synthesis path and beneficial to industrial production, and has a wide application prospect.

The application belongs to the technical field of organic electroluminescence, and relates to a N-containing polycyclic aromatic compound and application. The application provides a N-containing polycyclic aromatic compound, which generates a multiple resonance effect through interaction of each N atom in a N-containing fused ring. The multiple resonance effect can reduce the Stokes shift of the molecule, narrow the emission spectrum, and increase the rate of intersystem crossing inversion, so that a high-efficiency, high-color-purity luminescent material is obtained.

The invention discloses a quick response type near-infrared fluorescent probe for detecting Hg < 2 + >, a preparation method of the quick response type near-infrared fluorescent probe and application of the quick response type near-infrared fluorescent probe in actual water samples and biological imaging. The molecular formula of the fluorescent probe is C32H28N2O2S2. On the basis of a strategy of introducing phenothiazine heterocycle to expand xanthene pi conjugation, a large Stokes shift near infrared fluorescent probe for specifically recognizing Hg < 2 + > is constructed. An optical experiment shows that the emission wavelength of the probe for detecting Hg < 2 + > is 780nm, the Stokes shift reaches 166nm, and the probe has the advantages of high sensitivity (the detection limit is 13.4 nM), specificity, quick response (within 1s) and the like when being used for identifying Hg < 2 + >. Due to the excellent photophysical property, the fluorescent probe not only can be used for quantitatively detecting Hg < 2 + > in an environmental water sample, but also can be successfully applied to fluorescence imaging detection of Hg < 2 + > in cells and living bodies.

The application discloses an aggregation-induced emission material with high fluorescence quantum yield and large stokes shift, a preparation method and application thereof, and belongs to the technical field of preparation of the aggregation-induced emission material. The preparation method comprises the following steps: obtaining an intermediate by means of Suzuki-Miyaura coupling reaction of an organic boric acid and bromosalicylaldehyde; and adding the intermediate, sodium metabisulfite and aminophenylthiophenol into an organic solvent, and then performing high-temperature reaction to prepare the aggregation-induced emission material. The aggregation-induced emission material is synthesized by means of a two-step method, can be rapidly and mass-produced, and has the advantages of high fluorescence efficiency, large stokes shift, good stability and the like.

The invention provides a hypochlorous acid fluorescent probe with large Stokes shift and a preparation method and application thereof, and belongs to the technical field of hypochlorous acid fluorescent probes, the hypochlorous acid fluorescent probe is a cationic iridium (III) complex and contains antianions; the Stokes shift of the hypochlorous acid fluorescent probe is larger than or equal to 170 nm, background interference caused by overlapping of exciting light and an emission spectrum is reduced, and the detection signal-to-noise ratio is increased; the hypochlorous acid fluorescent probe disclosed by the invention has the characteristic of quick response to HOCl, and shows relatively high detection sensitivity and excellent selectivity; the hypochlorous acid fluorescent probe can trigger detectable fluorescence signal change after acting with HOCl in cells, so as to realize in-situ detection and imaging of HOCl in cells; the fluorescent probe can be applied to a lambda-carrageenan induced mouse arthritis model, in-vivo fluorescence imaging of endogenous HOCl signals in an inflammation joint area is achieved, and a sensitive and reliable imaging tool is provided for research of inflammation-related disease related HOCl.

The application discloses a degradable NaCeF4-based up / down conversion luminescent material and a preparation method and application thereof, and belongs to the technical field of luminescent materials. 4+ The molar ratio of Ce 3+ , Yb 3+ , Tm 4+ and Zr is (60-80):(18-22):(0.08-0.12):(2-20). The NaCeF4-based up / down conversion luminescent material has good degradability, high up-conversion emission efficiency, and an up-conversion emission Stokes shift increased to the ultraviolet region; the up-conversion luminescent material can simultaneously emit up-conversion luminescence and down-conversion luminescence under 980nm laser irradiation, and is expected to be used as a contrast agent for fluorescence imaging; and the preparation process is simple, environment-friendly and low in cost.