Benzylidene indandione compound and preparation thereof and application in specific imaging of lipid droplet

Abstract

The invention belongs to the field of medical materials, and discloses a benzylidene indandione compound and a preparation thereof and an application in specific imaging of a lipid droplet. The structure of the benzylidene indandione compound is as shown in a formula I. The benzylidene indandione compound has the advantage of aggregation-induced emission, and the defects of aggregation-induced quenching of a traditional fluorescent dye can be effectively overcome, so that the specific fluorescence imaging of the lipid droplet in a living cell can be achieved; furthermore, the benzylidene indandione compound has a two-photon absorption cross-section which is high in living cell penetration rate, high in signal to noise ratio, small in cytotoxicity, large in stokes shift and large in near infrared region. The formula I is as shown in the specification.

Description

Technical field

[0001] The invention belongs to the field of medical materials, and specifically relates to a compound with aggregation-induced luminescence properties, a preparation method thereof, and application in lipid droplet specific fluorescence imaging. Background technique

[0002] Lipid droplets are not only an important storage place for lipid molecules and proteins, but also a dynamically changing multifunctional organelle. The size and number of lipid droplets vary greatly among different cells. Since lipid droplets can not only serve as energy storage, but also play an important role in membrane synthesis and protein degradation. Lipid droplets are closely related to many diseases, including cancer, inflammation, viral infection and obesity.

[0003] Cancer cells have the characteristics of rapid proliferation, so there is a high demand for lipid molecules such as fatty acids and phospholipids, and the corresponding lipid droplet content in cancer cells is also sign...

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