Intra-gastric fastening devices are disclosed herein. Expandable devices that are inserted into the
stomach of the patient are maintained within by anchoring or otherwise fixing the expandable devices to the
stomach walls. Such expandable devices, like
inflatable balloons, have
tethering regions for attachment to the one or more fasteners which can be configured to extend at least partially through one or several folds of the patient's
stomach wall. The fasteners are thus affixed to the
stomach walls by deploying the fasteners and manipulating the tissue walls entirely from the inside of the organ. Such fasteners can be formed in a variety of configurations, e.g.,
helical, elongate, ring, clamp, and they can be configured to be non-piercing. Alternatively, sutures can be used to
wrap around or through a tissue fold for
tethering the expandable devices. Non-piercing biased clamps can also be used to tether the device within the stomach.