10 results about "Vagal nerve" patented technology

This application discloses the application of pyridostigmine in the preparation of drugs for the prevention and treatment of non-alcoholic fatty liver disease (NAFLD). Validation was conducted using animal models of NAFLD induced by three different etiologies: methionine-choline deficiency diet, high-fat diet, and leptin gene knockout. Pyridostigmine significantly improved vagal nerve activity in the model animals (e.g., improving high-frequency and baroreflex sensitivity in heart rate variability), effectively corrected serum lipid metabolism disorders (reducing LDL cholesterol), alleviated hepatocyte damage (reducing ALT and AST), and at the histopathological level, reduced hepatic steatosis, decreased inflammatory cell infiltration, and inhibited collagen deposition, thereby achieving the prevention and treatment of NAFLD.

The presently disclosed subject matter provides for in vitro methods of inducing differentiation of stem cells into hindbrain progenitor cells, enteric neural crest lineage cells, as well as differentiated hindbrain lineage or enteric neural crest lineage cells obtained by such methods. The presently disclosed subject matter also provides for uses of such cells for preventing and / or treating enteric nervous system disorders (e.g, Hirschsprung's disease), and for screening compounds suitable for preventing and / or treating enteric nervous system disorders (e.g., Hirschsprung's disease).

Provided herein are methods for treating autism; and systems and devices for administering transcutaneous auricular vagal nerve stimulation (taVNS).

The disclosure provides systems and methods for automatically titrating an electrical pulse amplitude for a patient-implanted VNS stimulator. One or more external sensors (e.g., EEG, EKG, EMG, auditory sensors, inertial motion sensors, etc.) can be applied to the patient to generate data relevant to an acceptable amplitude of the electrical pulse for a given cathode in a multi-cathode cuff. In one embodiment, the device may include a controller on the implanted VNS stimulator that receives data, e.g., using a wireless connection, from the external sensors and titrates upward the amplitude until an acceptable amplitude is determine that provides efficacy with minimal, if any, side effects.

The application discloses a kind of based on motor imagination and collaborative stimulation brain-computer interface rehabilitation training system and method.The system includes signal acquisition module, data processing module and collaborative stimulation module.Data processing module is based on affine invariant riemannian metric and Transform model according to the multi-channel electroencephalogram signal of acquisition, generates movement intention decoding result and trigger signal;Collaborative stimulation module responds to trigger signal, drives functional electrical stimulation and vagus nerve stimulation unit to execute synchronous stimulation, constitutes closed-loop rehabilitation training.The core lies in that decoding unit is reduced by dimension to electroencephalogram signal by based on affine invariant riemannian distance unsupervised clustering, then input Transform model classification, in combination with the double verification mechanism of trigger control unit, realize high-precision intention decoding and reliable trigger.The present application accurately synchronizes central nervous regulation and peripheral muscle feedback, effectively improves the neural remodeling efficiency and system generalization ability of motor function rehabilitation.

Example devices and techniques are disclosed for delivering neurostimulation therapy transesophageally. An example device includes stimulation circuitry configured to generate a transesophageal stimulation signal. The example device includes memory configured to store stimulation parameters that at least partially define the transesophageal stimulation signal and processing circuitry communicatively coupled to the memory, and the stimulation circuitry. The processing circuitry is configured to determine a maximum transesophageal stimulation amplitude value. The processing circuitry is configured to control the stimulation circuitry to generate the transesophageal stimulation signal based at least in part on at least one of the stimulation parameters or the maximum transesophageal stimulation amplitude such that an amplitude of the transesophageal stimulation signal does not exceed the maximum transesophageal stimulation amplitude.

A facial cold plunge device designed to enable prolonged and effective facial immersion in cold water for therapeutic, cosmetic, and wellness purposes. The device comprises an insulated housing unit with an ergonomically contoured reservoir, a chilling mechanism to maintain water temperatures below 50° F., and a thermostat-controlled interface for precise temperature adjustment. A closed-loop water circulation system, incorporating a filtration assembly, ensures consistent cooling and hygienic water conditions. The invention features a retractable breathing apparatus with a snorkel-like tube and a two-way check valve, allowing users to sustain facial submersion without interrupting respiration. The compact and portable design, combined with integrated chilling, filtration, and respiratory support systems, provides a convenient, efficient, and accessible solution for cold therapy, addressing the limitations of traditional full-body cold plunges and DIY facial immersion methods. Applications include stress reduction, vagus nerve stimulation, inflammation control, and various cosmetic benefits.

1. The name of the design product: nerve electrical stimulator (handheld). 2. The use of the design product: the design product is used for stimulating vagus nerve. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

A dual-sensor bone-conduction system enables real-time theranostic monitoring of vagal, vascular, and neuro-physiological activity through simultaneous acoustic fingerprinting and bio-impedance spectroscopy. A bone-conduction transducer transmits frequency-swept mechanical energy (32 Hz-1 MHz) while a piezoelectric receiver and tetrapolar electrodes capture reflected and dielectric responses. Machine-learning fusion of these signals yields indices of vascular resonance, mechanical-electrical coherence, and bilateral autonomic symmetry. Embodiments include cranial EEG-type headsets, thoracic ECG-type modules, smartwatches, veterinary collars, and plant-stress sensors. The system supports diagnostic imaging, closed-loop acoustic neuromodulation, and cross-species health or stress detection in a low-power, wearable, and non-invasive form factor.