58 results about "Vagal nerve" patented technology

The present invention relates to a method for controlling a complex stimulation, which is a method for controlling a complex stimulation device having an electrical stimulation unit including electrodes in contact with human ears and a sound output unit for stimulating hearing by using sound waves, wherein the sound output unit generates sound waves having different frequencies in both ears, and controls the frequency difference between the sound waves applied to both ears on the basis of frequencies of electrical stimulation applied to the electrodes. The present invention has an excellent effect of improving the efficiency of electrical stimulation to the vagus nerve by stimulating the brain with two types of stimulation by adding acoustic stimulation together when stimulating the vagus nerve through the electrodes in contact with the ears.

The invention relates to the technical field of waking-up training monitoring systems, in particular to a disturbance of consciousness waking-up training monitoring system, which is characterized in that a brain wave response analysis module is used for analyzing and obtaining related information of brain waves of a patient; the action response analysis module is used for analyzing and obtaining related information of response after the patient completes the action; the control module obtains a patient state factor; the training intensity judgment module obtains information about whether the patient adapts to wake-up training or not; the brain wave monitoring module obtains total brain wave power and delta wave power; the stimulation intensity analysis module obtains intensity adjustment information; the vagus nerve electrical stimulation module starts power-off stimulation according to the information whether the patient adapts to waking-up training, and the electrical stimulation intensity is improved, reduced or maintained according to the vagus nerve electrical stimulation module. The system can more comprehensively reflect the state of the patient in the training process, provides data support for personalized treatment, and is beneficial to improving the overall flexibility.

The invention discloses a minimally invasive flexible piezoelectric-triboelectric hybrid nanometer nerve stimulation device and application thereof.The middle layer of the nerve stimulation device is a PVDF / TMCM-MnCl3 composite nanofiber membrane, Au electrodes are evaporated on the two faces of the PVDF / TMCM-MnCl3 composite nanofiber membrane, two gold wire or copper wire electrodes are connected with the Au electrodes respectively, and the two gold wire or copper wire electrodes are connected with the Au electrodes respectively. The surface of the Au electrode is subjected to primary packaging by adopting a PU waterproof film, and the surface of the PU waterproof film is subjected to secondary packaging by adopting PDMS. The nerve stimulation device is used for conventional treatment of SIRS. The vagus nerve stimulator can generate an adjustable current up to 0.85 mA under programmable ultrasonic driving, and can be directly used for VNS. The PTNG is ultrasonically driven in vitro to assist the VNS in treating lipopolysaccharide-induced SIRS rats, release of inflammatory factors such as TNF-alpha, IFN-gamma and IL-1beta can be effectively reduced, cytokine storm is relieved, and multi-organ tissue damage and dysfunction are relieved, so that the survival hope is improved.

Disclosed herein is a device for auricular vagal nerve stimulation in a. subject, said device having an electrode configuration including at least one electrode contact operative to be adhered to a first portion of inner skin surface of an ear Concha of the subject, and at least one return electrode with an opposite polarity operative to be adhered to a second portion of the inner skin surface.

The utility model relates to an ear vagus nerve stimulator, which comprises a base body, a first electrode and a second electrode which are connected to the base body, and a power supply circuit board arranged in the base body, each of the first electrode and the second electrode comprises a contact layer used for being in contact with the skin in the ear, a conductive film embedded in the inner side of the contact layer and a phase change material core wrapped in the conductive film, the contact layers are deformable and conductive, and the contact layers and the conductive films in the first electrode and the second electrode are electrically connected with the power supply circuit board. According to the ear vagus nerve stimulator, the first electrode and the second electrode are arranged to be of a multi-layer structure, and the shape of the phase change material core is changed by switching on and off the conductive film, so that the first electrode and the second electrode deform to be better matched with the ear cavity structure of a user, the wearing comfort is improved, and meanwhile, the proper electrical stimulation effect is ensured.

Vagal nerve stimulation devices and methods are provided herein. A device comprises one or more electrodes having a contact surface for contacting an outer skin surface of a patient and an energy source coupled to the electrodes. The energy source generates one or more electrical impulses and transmits the electrical impulses to the electrodes and transcutaneously through the outer skin surface of the patient at or near a vagus nerve. The one or more electrical pulses comprise bursts of 2 to 20 pulses within each burst with each burst having a frequency of about 5 Hz to about 100 Hz.

The invention discloses an electrical stimulation therapeutic apparatus for ear vagus nerves, which comprises a USB power supply, a battery management module, an LDO voltage reduction and stabilization module, an MCU module, a Boost module, two stimulation current driving modules, an ear electrode and an ear electrode detection module, and is characterized in that the power supply management module is composed of a TP4056 chip, an external element, a power supply input USB Type-C interface and a battery connection interface; the external element is used for setting charging current, filtering and other functions, the power supply input interface can be connected with a USB power supply, the USB power supply is a lithium ion battery, and the battery connection interface is connected with the lithium ion battery. The therapeutic apparatus has flexible stimulation parameter adjusting functions including stimulation intensity, stimulation frequency, current direction, pulse width and the like so as to adapt to different diseases, different disease severity degrees and tolerance and reactivity differences of different individuals to stimulation, and accurate personalized treatment is achieved.

The invention discloses a medical double-core-layer pressure-resistant sensing balloon and a preparation method thereof.The medical double-core-layer pressure-resistant sensing balloon comprises a balloon body connected with a catheter, the balloon body is of a double-core-layer shell layer structure, and a core layer comprises a developing and pressure sensing double-core structure; a developing agent is loaded in the inner core layer balloon, the position of the balloon is effectively displayed, it can be guaranteed that the core layer is not affected after the outer layer is damaged, the inner layer and the other core layer balloon can synchronously conduct pressure sensing, and the shell layer is a compression layer with toughness and bursting pressure and can be coated with a medicine coating. According to the medical double-core-layer high-pressure-resistant balloon provided by the invention, through the design of the internal double core layers, accurate control of pressure is effectively realized, and the problem that a developing agent leaks out of the brain after the outer layer of the balloon is broken in a trigeminal nerve minimally invasive puncture balloon compression operation is prevented; and by controlling the surface roughness of the outer layer, medicine coating can be carried out, so that vagus nerve reflex is prevented, and the problem of high risks of sudden blood pressure rise and sudden heartbeat arrest caused by compression in the operation process is solved.

Multifunctional microelectronics fiber probes can be chronically implanted in tissue of awake-behaving animals for understanding brain-viscera communication. These fiber probes can be made using thermal drawing to make hundreds of meters of flexible fiber that incorporates features such as light sources, electrodes, thermal sensors, and microfluidic channels in a multilayered configuration. The fiber mechanics can be tuned for two distinct device layouts: (1) higher-modulus, flexible brain fibers for implantation into deep-brain; and (2) soft, compliant gut fibers for implantation into the small intestine. Brain fibers can modulate the deep-brain mesolimbic reward pathway. Gut fibers can perform peripheral optogenetic stimulation of vagal afferents from the intestine to stimulate brain reward neurons. Brain and gut fibers can be connected to a control module, for example, with a coiled, stretchable interconnect that is more flexible and stretches more than even soft gut fibers, in dual-organ (gut-brain) implantation.

In an illustrative embodiment, methods and systems for treating uterine bleeding include applying, at least every other day in which a subject exhibits or is expected to exhibit menstrual bleeding, neurostimulation therapy in one or more sessions, each session having a duration of at least five minutes, the neurostimulation therapy including applying electrical neurostimulation or mechanical neurostimulation to directly and / or indirectly activate one or more neural targets, the one or more neural targets including a trigeminal cervical complex and / or vagal efferent fibers. The neurostimulation therapy may be configured to enhance platelet function of the subject, thereby reducing a total volume of blood loss over a course of the menstrual bleeding.

Disclosed is a system, a device, and a method for neuro-acoustic vagal modulation The method includes the steps of receiving (706) a session type selection, determining 5 (708) stimulation parameters, generating (710) stimulation signals, and transmitting (712) the signals to a neuro-acoustic vagal modulation device (102) positioned behind a user's ear. The method includes receiving (714) physiological response data from the device (102) or an auxiliary wearable device (108), dynamically adjusting (716) the stimulation parameters based on the received data, and transmitting (718) the adjusted 10 signals to the device (102).

This disclosure relates to medical implant systems and apparatuses capable of treating a seizure condition through the use of recording and stimulating electrodes. The apparatus includes an internal pulse generator in communication with a wireless communication module; one or more recording electrodes in communication with the internal pulse generator, wherein the one or more recording electrodes are configured to monitor to detect one or more field potentials produced by neural tissue in proximity to the one or more recording electrodes; one or more stimulating electrodes in communication with the internal pulse generator, wherein the one or more stimulating electrodes are configured to stimulate the vagus nerve.

This application discloses the application of pyridostigmine in the preparation of drugs for the prevention and treatment of non-alcoholic fatty liver disease (NAFLD). Validation was conducted using animal models of NAFLD induced by three different etiologies: methionine-choline deficiency diet, high-fat diet, and leptin gene knockout. Pyridostigmine significantly improved vagal nerve activity in the model animals (e.g., improving high-frequency and baroreflex sensitivity in heart rate variability), effectively corrected serum lipid metabolism disorders (reducing LDL cholesterol), alleviated hepatocyte damage (reducing ALT and AST), and at the histopathological level, reduced hepatic steatosis, decreased inflammatory cell infiltration, and inhibited collagen deposition, thereby achieving the prevention and treatment of NAFLD.

In an illustrative embodiment, methods and systems for treating uterine bleeding include applying, at least every other day in which a subject exhibits or is expected to exhibit menstrual bleeding, neurostimulation therapy in one or more sessions, each session having a duration of at least five minutes, the neurostimulation therapy including applying electrical neurostimulation or mechanical neurostimulation to directly and / or indirectly activate one or more neural targets, the one or more neural targets including a trigeminal cervical complex and / or vagal efferent fibers. The neurostimulation therapy may be configured to enhance platelet function of the subject, thereby reducing a total volume of blood loss over a course of the menstrual bleeding.

The invention discloses a bionic gastric mucosa micro-barrier structure, comprising: a bottom microfluidic channel for simulating a submucosal vascular network; the middle gastric epithelial cell layer is used for simulating a mucous membrane epithelial barrier and comprises a matrix layer, quaternary functional cells, a culture medium and a pH buffer module; and the surface dynamic mucus layer is used for simulating a mucous membrane protective barrier and comprises a vagus neurotransmitter simulant, exogenous mucus and a pressure sensor. According to the invention, continuous nutrition supply is provided for the middle gastric epithelial cell layer through the bottom microfluidic channel, the survival and functions of cells are maintained, and accurate tracking of the transgastric mucosa transport process is realized. A function collaborative network is formed through quaternary cells, the secretion volume and the injury state are monitored in real time, regulatory factors are dynamically adjusted, and it is ensured that a cell layer can still maintain the barrier function stable under external interference. When foreign matter impact or food friction signals are recognized through the pressure sensor, the pump speed is instantly increased, and local mucus loss is rapidly supplemented.

The disclosure relates to a system comprising a device that includes electrodes and a sensor operably connected in electrical communication with a controller housing a computer program product that calculates heart rate and mean arterial blood pressure in the circulatory system of a subject by the sensor being placed at or proximate to the cardiac tissue of the subject. Electrodes on the device stimulate the vagal nerve to restore heart rate and arterial blood pressure to normal levels if an abnormality is detected.

A neural stimulator, suitable for implanting in a recipient, and configured to combine vagal nerve stimulation (VNS) with cochlear stimulation, to result in faster adaptation to new sounds and maps, and alleviation of tinnitus in the recipient.

The presently disclosed subject matter provides for in vitro methods of inducing differentiation of stem cells into hindbrain progenitor cells, enteric neural crest lineage cells, as well as differentiated hindbrain lineage or enteric neural crest lineage cells obtained by such methods. The presently disclosed subject matter also provides for uses of such cells for preventing and / or treating enteric nervous system disorders (e.g, Hirschsprung's disease), and for screening compounds suitable for preventing and / or treating enteric nervous system disorders (e.g., Hirschsprung's disease).

The utility model relates to the field of experiment devices, in particular to a mouse experiment fixing device which comprises a shell and a bottom plate, a fixing mechanism used for fixing a mouse body is arranged on the shell, one end of the shell is a closed end, and the other end of the shell is an open end. The head fixing block is opposite to the closed end, and a head groove is formed in the side face, opposite to the closed end, of the head fixing block; and a clamp avoiding hole is formed in the side wall of the head fixing block. By means of the scheme, in the ear vagus nerve stimulation experiment, the head of a mouse is fixed, and electric stimulation can be conveniently conducted on the ears of the mouse.

Methods and apparatuses for treating a senescence related disease, disorder, or pathological condition. These methods may include identifying a cellular senescence status in a senescence related disease, disorder, or pathological condition in a subject; and treating the subject for the senescence-related disease, disorder, or conditional by vagal nerve stimulation.

In an illustrative embodiment, methods and systems for treating fertility conditions in women diagnosed with polycystic ovary syndrome (PCOS), endometriosis, and / or adenomyosis using electrical neurostimulation include delivering neurostimulation therapy via electrical or mechanical stimulation elements, the neurostimulation therapy including applying first neurostimulation pulses using electrical neurostimulation or mechanical neurostimulation at one or more first regions of skin of the subject to directly and / or indirectly activate a nucleus tractus solitary (NTS) and / or a trigeminal cervical complex (TCC) to activate anti-inflammatory pathways, and applying second neurostimulation pulses using electrical neurostimulation or mechanical neurostimulation at one or more second regions of skin of the subject to directly and / or indirectly activate vagal neural fibers and / or trigeminal neural fibers, wherein the neurostimulation pulses are configured to increase a parasympathetic / sympathetic (P / S) ratio.

Disclosed is a system, a device, and a method for neuro-acoustic vagal modulation. The method includes the steps of receiving (706) a session type selection, determining (708) stimulation parameters, generating (710) stimulation signals, and transmitting (712) the signals to a neuro-acoustic vagal modulation device (102) positioned behind a user's ear. The method includes receiving (714) physiological response data from the device (102) or an auxiliary wearable device (108), dynamically adjusting (716) the stimulation parameters based on the received data, and transmitting (718) the adjusted signals to the device (102).

The invention discloses a psychological intervention method of a wearable relaxation device, the wearable relaxation device comprises a wearable waistcoat and a headgear, the front and back of the wearable waistcoat are both provided with a heating sheet and an air bag, and the headgear is internally provided with an ultrasonic generator; a user wears the head sleeve on the head of the waistcoat; an ultrasonic generator emits audio stimulation of specific brain wave guiding components, brain activities of a treated individual are guided to a deep relaxation or semi-sleep state mainly including alpha waves (8-12 Hz) and theta waves (4-8 Hz), and dominant defense and high-alertness reactions are reduced; by means of linguistic or audio meditation guidance, establishment of a safety scene is assisted, excessive activation of sympathetic nerves is reduced, and vagus nerve dominance is improved; the obvious improvement in the aspects of sleep, emotion, self value feeling and the like can be observed in 7-14 days; the original energy feeling is reprogrammed through a multi-layer path, the deep subconsciousness is changed, and the recurrence probability is low.

The present invention is a method for applying electrical stimulation to the vagus nerve via an electrode in contact with the skin of a human body, and is characterized by including an electrical stimulation guideline input step of inputting an electrical stimulation guideline including a numerical value for the electrical stimulation, an initial input value derivation step of measuring the impedance between the electrode and the skin before applying the electrical stimulation and deriving an input value that matches the electrical stimulation guideline using the measured impedance, and an electrical stimulation application step of applying the electrical stimulation with the derived initial input value. The present invention has an advantage that more accurate electrical stimulation can be applied by applying electrical stimulation to the electrodes while reflecting the impedance between the electrodes and the user's skin, and that accurate electrical stimulation can be continuously applied by applying electrical stimulation while reflecting changes in impedance between the skin and the electrodes during use.

The invention discloses a brain earphone interface device, and relates to the technical field of auricular point treatment, the brain earphone interface device comprises an electroencephalogram collector, the rear side of the electroencephalogram collector is fixedly connected with a controller, the electroencephalogram collector is electrically connected with the controller, the bottom of the controller is fixedly connected with a wire, the tail end of the wire is fixedly connected with two earphones, and the two earphones are electrically connected with the controller. The controller is electrically connected with the earphone through a wire. An electroencephalogram signal of a user is collected through an electroencephalogram collector, and then the current state of the user, such as a fatigue state, a depression state and the like, is recognized according to cooperation of a collection module and a controller; then according to the current condition of the user, refreshing music is selectively played through the player or the first electrode slice and the second electrode slice are matched to stimulate the ear vagus nerve of the user for treatment, and compared with traditional pure active auricular point treatment, real-time treatment is carried out in cooperation with electroencephalogram signals, the treatment effect is better, and use is more convenient.

Provided herein are methods for treating autism; and systems and devices for administering transcutaneous auricular vagal nerve stimulation (taVNS).

The invention discloses a biodegradable capacitance coupling nerve stimulator used for radio therapy inflammation, the capacitance coupling nerve stimulator comprises a nerve stimulation element and a packaging element, the packaging element is located on the surface of the nerve stimulation element, the packaging element is an elastomer SBPUE, and the packaging element is located on the surface of the nerve stimulation element. The preparation method of the elastomer SBPUE comprises the following steps: S1, mixing PCL and PTMEG in a container, heating the mixture in a vacuum oil bath at 100 DEG C to remove moisture, and then cooling to 70 DEG C; s2, dropwise adding isophorone diisocyanate dissolved in DMAc and DBTDL into the container, stirring in a nitrogen atmosphere, synthesizing a prepolymer, and cooling to room temperature; s3, adding dimethyl glyoxime dissolved in DMAc as a chain extender, and carrying out a sealed reaction; s4, after the reaction is completed, DMAc is added to adjust the concentration of a product to 30 wt%, and the elastomer SBPUE is obtained. Chronic electrical stimulation is carried out on vagus nerves in a young rat model, and successful application of the vagus nerves in electronic drug anti-inflammatory treatment of PIBD is proved.

1. The name of the design product: ear electric stimulation device. 2. The use of the design product: the design product is used for ear electrode matched with ear vagus nerve stimulation instrument, which is worn on ear to act on ear vagus nerve. 3. The design points of the design product: the combination of shape and color. 4. The picture or photo that best shows the design points: perspective view. 5. The design claimed contains color.

1. The name of the design product: ear vagus nerve stimulation electrode. 2. The use of the design product: for the auxiliary treatment of mental illness and nerve rehabilitation. 3. The design points of the design product: in the overall shape of the product. 4. The picture or photo that best indicates the design points: perspective view.

1. The name of the design product: ear vagus nerve stimulation electrode. 2. The use of the design product: for the auxiliary treatment of mental illness and nerve rehabilitation. 3. The design points of the design product: in the overall shape of the product. 4. The picture or photo that best indicates the design points: perspective view.