46 results about "Vagal nerve" patented technology

The invention relates to the technical field of waking-up training monitoring systems, in particular to a disturbance of consciousness waking-up training monitoring system, which is characterized in that a brain wave response analysis module is used for analyzing and obtaining related information of brain waves of a patient; the action response analysis module is used for analyzing and obtaining related information of response after the patient completes the action; the control module obtains a patient state factor; the training intensity judgment module obtains information about whether the patient adapts to wake-up training or not; the brain wave monitoring module obtains total brain wave power and delta wave power; the stimulation intensity analysis module obtains intensity adjustment information; the vagus nerve electrical stimulation module starts power-off stimulation according to the information whether the patient adapts to waking-up training, and the electrical stimulation intensity is improved, reduced or maintained according to the vagus nerve electrical stimulation module. The system can more comprehensively reflect the state of the patient in the training process, provides data support for personalized treatment, and is beneficial to improving the overall flexibility.

The invention discloses a minimally invasive flexible piezoelectric-triboelectric hybrid nanometer nerve stimulation device and application thereof.The middle layer of the nerve stimulation device is a PVDF / TMCM-MnCl3 composite nanofiber membrane, Au electrodes are evaporated on the two faces of the PVDF / TMCM-MnCl3 composite nanofiber membrane, two gold wire or copper wire electrodes are connected with the Au electrodes respectively, and the two gold wire or copper wire electrodes are connected with the Au electrodes respectively. The surface of the Au electrode is subjected to primary packaging by adopting a PU waterproof film, and the surface of the PU waterproof film is subjected to secondary packaging by adopting PDMS. The nerve stimulation device is used for conventional treatment of SIRS. The vagus nerve stimulator can generate an adjustable current up to 0.85 mA under programmable ultrasonic driving, and can be directly used for VNS. The PTNG is ultrasonically driven in vitro to assist the VNS in treating lipopolysaccharide-induced SIRS rats, release of inflammatory factors such as TNF-alpha, IFN-gamma and IL-1beta can be effectively reduced, cytokine storm is relieved, and multi-organ tissue damage and dysfunction are relieved, so that the survival hope is improved.

Vagal nerve stimulation devices and methods are provided herein. A device comprises one or more electrodes having a contact surface for contacting an outer skin surface of a patient and an energy source coupled to the electrodes. The energy source generates one or more electrical impulses and transmits the electrical impulses to the electrodes and transcutaneously through the outer skin surface of the patient at or near a vagus nerve. The one or more electrical pulses comprise bursts of 2 to 20 pulses within each burst with each burst having a frequency of about 5 Hz to about 100 Hz.

The invention discloses a medical double-core-layer pressure-resistant sensing balloon and a preparation method thereof.The medical double-core-layer pressure-resistant sensing balloon comprises a balloon body connected with a catheter, the balloon body is of a double-core-layer shell layer structure, and a core layer comprises a developing and pressure sensing double-core structure; a developing agent is loaded in the inner core layer balloon, the position of the balloon is effectively displayed, it can be guaranteed that the core layer is not affected after the outer layer is damaged, the inner layer and the other core layer balloon can synchronously conduct pressure sensing, and the shell layer is a compression layer with toughness and bursting pressure and can be coated with a medicine coating. According to the medical double-core-layer high-pressure-resistant balloon provided by the invention, through the design of the internal double core layers, accurate control of pressure is effectively realized, and the problem that a developing agent leaks out of the brain after the outer layer of the balloon is broken in a trigeminal nerve minimally invasive puncture balloon compression operation is prevented; and by controlling the surface roughness of the outer layer, medicine coating can be carried out, so that vagus nerve reflex is prevented, and the problem of high risks of sudden blood pressure rise and sudden heartbeat arrest caused by compression in the operation process is solved.

In an illustrative embodiment, methods and systems for treating uterine bleeding include applying, at least every other day in which a subject exhibits or is expected to exhibit menstrual bleeding, neurostimulation therapy in one or more sessions, each session having a duration of at least five minutes, the neurostimulation therapy including applying electrical neurostimulation or mechanical neurostimulation to directly and / or indirectly activate one or more neural targets, the one or more neural targets including a trigeminal cervical complex and / or vagal efferent fibers. The neurostimulation therapy may be configured to enhance platelet function of the subject, thereby reducing a total volume of blood loss over a course of the menstrual bleeding.

Disclosed is a system, a device, and a method for neuro-acoustic vagal modulation The method includes the steps of receiving (706) a session type selection, determining 5 (708) stimulation parameters, generating (710) stimulation signals, and transmitting (712) the signals to a neuro-acoustic vagal modulation device (102) positioned behind a user's ear. The method includes receiving (714) physiological response data from the device (102) or an auxiliary wearable device (108), dynamically adjusting (716) the stimulation parameters based on the received data, and transmitting (718) the adjusted 10 signals to the device (102).

This disclosure relates to medical implant systems and apparatuses capable of treating a seizure condition through the use of recording and stimulating electrodes. The apparatus includes an internal pulse generator in communication with a wireless communication module; one or more recording electrodes in communication with the internal pulse generator, wherein the one or more recording electrodes are configured to monitor to detect one or more field potentials produced by neural tissue in proximity to the one or more recording electrodes; one or more stimulating electrodes in communication with the internal pulse generator, wherein the one or more stimulating electrodes are configured to stimulate the vagus nerve.

This application discloses the application of pyridostigmine in the preparation of drugs for the prevention and treatment of non-alcoholic fatty liver disease (NAFLD). Validation was conducted using animal models of NAFLD induced by three different etiologies: methionine-choline deficiency diet, high-fat diet, and leptin gene knockout. Pyridostigmine significantly improved vagal nerve activity in the model animals (e.g., improving high-frequency and baroreflex sensitivity in heart rate variability), effectively corrected serum lipid metabolism disorders (reducing LDL cholesterol), alleviated hepatocyte damage (reducing ALT and AST), and at the histopathological level, reduced hepatic steatosis, decreased inflammatory cell infiltration, and inhibited collagen deposition, thereby achieving the prevention and treatment of NAFLD.

In an illustrative embodiment, methods and systems for treating uterine bleeding include applying, at least every other day in which a subject exhibits or is expected to exhibit menstrual bleeding, neurostimulation therapy in one or more sessions, each session having a duration of at least five minutes, the neurostimulation therapy including applying electrical neurostimulation or mechanical neurostimulation to directly and / or indirectly activate one or more neural targets, the one or more neural targets including a trigeminal cervical complex and / or vagal efferent fibers. The neurostimulation therapy may be configured to enhance platelet function of the subject, thereby reducing a total volume of blood loss over a course of the menstrual bleeding.

The invention discloses a bionic gastric mucosa micro-barrier structure, comprising: a bottom microfluidic channel for simulating a submucosal vascular network; the middle gastric epithelial cell layer is used for simulating a mucous membrane epithelial barrier and comprises a matrix layer, quaternary functional cells, a culture medium and a pH buffer module; and the surface dynamic mucus layer is used for simulating a mucous membrane protective barrier and comprises a vagus neurotransmitter simulant, exogenous mucus and a pressure sensor. According to the invention, continuous nutrition supply is provided for the middle gastric epithelial cell layer through the bottom microfluidic channel, the survival and functions of cells are maintained, and accurate tracking of the transgastric mucosa transport process is realized. A function collaborative network is formed through quaternary cells, the secretion volume and the injury state are monitored in real time, regulatory factors are dynamically adjusted, and it is ensured that a cell layer can still maintain the barrier function stable under external interference. When foreign matter impact or food friction signals are recognized through the pressure sensor, the pump speed is instantly increased, and local mucus loss is rapidly supplemented.

The disclosure relates to a system comprising a device that includes electrodes and a sensor operably connected in electrical communication with a controller housing a computer program product that calculates heart rate and mean arterial blood pressure in the circulatory system of a subject by the sensor being placed at or proximate to the cardiac tissue of the subject. Electrodes on the device stimulate the vagal nerve to restore heart rate and arterial blood pressure to normal levels if an abnormality is detected.

The presently disclosed subject matter provides for in vitro methods of inducing differentiation of stem cells into hindbrain progenitor cells, enteric neural crest lineage cells, as well as differentiated hindbrain lineage or enteric neural crest lineage cells obtained by such methods. The presently disclosed subject matter also provides for uses of such cells for preventing and / or treating enteric nervous system disorders (e.g, Hirschsprung's disease), and for screening compounds suitable for preventing and / or treating enteric nervous system disorders (e.g., Hirschsprung's disease).

Methods and apparatuses for treating a senescence related disease, disorder, or pathological condition. These methods may include identifying a cellular senescence status in a senescence related disease, disorder, or pathological condition in a subject; and treating the subject for the senescence-related disease, disorder, or conditional by vagal nerve stimulation.

In an illustrative embodiment, methods and systems for treating fertility conditions in women diagnosed with polycystic ovary syndrome (PCOS), endometriosis, and / or adenomyosis using electrical neurostimulation include delivering neurostimulation therapy via electrical or mechanical stimulation elements, the neurostimulation therapy including applying first neurostimulation pulses using electrical neurostimulation or mechanical neurostimulation at one or more first regions of skin of the subject to directly and / or indirectly activate a nucleus tractus solitary (NTS) and / or a trigeminal cervical complex (TCC) to activate anti-inflammatory pathways, and applying second neurostimulation pulses using electrical neurostimulation or mechanical neurostimulation at one or more second regions of skin of the subject to directly and / or indirectly activate vagal neural fibers and / or trigeminal neural fibers, wherein the neurostimulation pulses are configured to increase a parasympathetic / sympathetic (P / S) ratio.

Disclosed is a system, a device, and a method for neuro-acoustic vagal modulation. The method includes the steps of receiving (706) a session type selection, determining (708) stimulation parameters, generating (710) stimulation signals, and transmitting (712) the signals to a neuro-acoustic vagal modulation device (102) positioned behind a user's ear. The method includes receiving (714) physiological response data from the device (102) or an auxiliary wearable device (108), dynamically adjusting (716) the stimulation parameters based on the received data, and transmitting (718) the adjusted signals to the device (102).

The invention discloses a psychological intervention method of a wearable relaxation device, the wearable relaxation device comprises a wearable waistcoat and a headgear, the front and back of the wearable waistcoat are both provided with a heating sheet and an air bag, and the headgear is internally provided with an ultrasonic generator; a user wears the head sleeve on the head of the waistcoat; an ultrasonic generator emits audio stimulation of specific brain wave guiding components, brain activities of a treated individual are guided to a deep relaxation or semi-sleep state mainly including alpha waves (8-12 Hz) and theta waves (4-8 Hz), and dominant defense and high-alertness reactions are reduced; by means of linguistic or audio meditation guidance, establishment of a safety scene is assisted, excessive activation of sympathetic nerves is reduced, and vagus nerve dominance is improved; the obvious improvement in the aspects of sleep, emotion, self value feeling and the like can be observed in 7-14 days; the original energy feeling is reprogrammed through a multi-layer path, the deep subconsciousness is changed, and the recurrence probability is low.

The present invention is a method for applying electrical stimulation to the vagus nerve via an electrode in contact with the skin of a human body, and is characterized by including an electrical stimulation guideline input step of inputting an electrical stimulation guideline including a numerical value for the electrical stimulation, an initial input value derivation step of measuring the impedance between the electrode and the skin before applying the electrical stimulation and deriving an input value that matches the electrical stimulation guideline using the measured impedance, and an electrical stimulation application step of applying the electrical stimulation with the derived initial input value. The present invention has an advantage that more accurate electrical stimulation can be applied by applying electrical stimulation to the electrodes while reflecting the impedance between the electrodes and the user's skin, and that accurate electrical stimulation can be continuously applied by applying electrical stimulation while reflecting changes in impedance between the skin and the electrodes during use.

The invention discloses a brain earphone interface device, and relates to the technical field of auricular point treatment, the brain earphone interface device comprises an electroencephalogram collector, the rear side of the electroencephalogram collector is fixedly connected with a controller, the electroencephalogram collector is electrically connected with the controller, the bottom of the controller is fixedly connected with a wire, the tail end of the wire is fixedly connected with two earphones, and the two earphones are electrically connected with the controller. The controller is electrically connected with the earphone through a wire. An electroencephalogram signal of a user is collected through an electroencephalogram collector, and then the current state of the user, such as a fatigue state, a depression state and the like, is recognized according to cooperation of a collection module and a controller; then according to the current condition of the user, refreshing music is selectively played through the player or the first electrode slice and the second electrode slice are matched to stimulate the ear vagus nerve of the user for treatment, and compared with traditional pure active auricular point treatment, real-time treatment is carried out in cooperation with electroencephalogram signals, the treatment effect is better, and use is more convenient.

Provided herein are methods for treating autism; and systems and devices for administering transcutaneous auricular vagal nerve stimulation (taVNS).

The invention discloses a biodegradable capacitance coupling nerve stimulator used for radio therapy inflammation, the capacitance coupling nerve stimulator comprises a nerve stimulation element and a packaging element, the packaging element is located on the surface of the nerve stimulation element, the packaging element is an elastomer SBPUE, and the packaging element is located on the surface of the nerve stimulation element. The preparation method of the elastomer SBPUE comprises the following steps: S1, mixing PCL and PTMEG in a container, heating the mixture in a vacuum oil bath at 100 DEG C to remove moisture, and then cooling to 70 DEG C; s2, dropwise adding isophorone diisocyanate dissolved in DMAc and DBTDL into the container, stirring in a nitrogen atmosphere, synthesizing a prepolymer, and cooling to room temperature; s3, adding dimethyl glyoxime dissolved in DMAc as a chain extender, and carrying out a sealed reaction; s4, after the reaction is completed, DMAc is added to adjust the concentration of a product to 30 wt%, and the elastomer SBPUE is obtained. Chronic electrical stimulation is carried out on vagus nerves in a young rat model, and successful application of the vagus nerves in electronic drug anti-inflammatory treatment of PIBD is proved.

1. The name of the design product: ear electric stimulation device. 2. The use of the design product: the design product is used for ear electrode matched with ear vagus nerve stimulation instrument, which is worn on ear to act on ear vagus nerve. 3. The design points of the design product: the combination of shape and color. 4. The picture or photo that best shows the design points: perspective view. 5. The design claimed contains color.

1. The name of the design product: ear vagus nerve stimulation electrode. 2. The use of the design product: for the auxiliary treatment of mental illness and nerve rehabilitation. 3. The design points of the design product: in the overall shape of the product. 4. The picture or photo that best indicates the design points: perspective view.

1. The name of the design product: ear vagus nerve stimulation electrode. 2. The use of the design product: for the auxiliary treatment of mental illness and nerve rehabilitation. 3. The design points of the design product: in the overall shape of the product. 4. The picture or photo that best indicates the design points: perspective view.

Methods and apparatuses (e.g., devices and systems) for securely accessing, activating and / or updating vagus nerve stimulators. In particular, described herein are methods and apparatuses for securing providing, verifying and / or executing digital prescriptions for implantable (including implanted) vagus nerve stimulation systems that may be used for treating inflammation. These methods and apparatuses (including software and / or firmware) may be adapted for used with low-energy requirements of the implanted components.

In an illustrative embodiment, methods and systems for treating uterine bleeding include applying, at least every other day in which a subject exhibits or is expected to exhibit menstrual bleeding, neurostimulation therapy in one or more sessions, each session having a duration of at least five minutes, the neurostimulation therapy including applying electrical neurostimulation or mechanical neurostimulation to directly and / or indirectly activate one or more neural targets, the one or more neural targets including a trigeminal cervical complex and / or vagal efferent fibers. The neurostimulation therapy may be configured to enhance platelet function of the subject, thereby reducing a total volume of blood loss over a course of the menstrual bleeding.

A self-administrable apparatus for performing non-invasive neurostimulation therapy of a living mammal on-demand, said self-administrable non-invasive neurostimulation apparatus comprising: one or more configured irradiation units comprising a portable hollow casing having fixed dimensions, a sized internal spatial volume and an external surface configuration suitable for application to a body, and a controller assembly able to control on-demand delivery of light energy from said configured irradiation units into an interior part of the body in-vivo.

The disclosure provides systems and methods for automatically titrating an electrical pulse amplitude for a patient-implanted VNS stimulator. One or more external sensors (e.g., EEG, EKG, EMG, auditory sensors, inertial motion sensors, etc.) can be applied to the patient to generate data relevant to an acceptable amplitude of the electrical pulse for a given cathode in a multi-cathode cuff. In one embodiment, the device may include a controller on the implanted VNS stimulator that receives data, e.g., using a wireless connection, from the external sensors and titrates upward the amplitude until an acceptable amplitude is determine that provides efficacy with minimal, if any, side effects.

A method and eyewear apparatus for reducing visual triggers during vascular access or interventional procedures or other medical procedures or treatments. One method uses a vision-restricting eyewear apparatus comprising a lens with an opaque lower region and an affixed compressible foam pad that together obstruct the subject's lower field of vision while preserving partial forward or upward visibility. When worn, the apparatus forms at least a substantially continuous, gapless visual barrier that limits exposure to procedural stimuli for effective blocking. The method and apparatus aim to reduce physiological and psychological distress, including vasovagal responses. In one non-limiting embodiment, a vision-restricting apparatus and associated method are provided for reducing visual triggers during vascular access, breast biopsy, or other interventional procedures. The apparatus includes a lens or eyeshield having an opaque lower region configured to obstruct the user's inferior visual field while preserving forward or upward visibility through a transparent upper region. Affixed along the lower edge of the lens is a compressible, skin-safe foam or other interface that deforms by folding or bending against itself, forming a continuous, gapless visual barrier that conforms to a variety of facial anatomies. In some embodiments, the apparatus comprises a single continuous lens or eyeshield body or discrete lenses for each eye, and may further include a support frame or adhesive interface for facial adhesive of the apparatus to a patient. The method comprises applying the apparatus immediately prior to a needle-based or image-guided procedure to position the visual obstruction in place, thereby reducing physiological or psychological distress—such as vasovagal responses—by blocking distress-inducing stimuli within the lower visual field. The apparatus is suitable for single-use disposable application.

A method and an apparatus for facilitating stimulating of vagal nerves in a neck region of a user by utilizing pulsed short-wave therapy technology for purposes of treating chronic inflammation throughout a body of the user. The apparatus includes an apparatus body, a signal generating device, a field generating element, and a powering device. The apparatus body is configured to be placed on a part of the body. The signal generating device is placed in the apparatus body and configured for generating a signal with a signal characteristic. The field generating element is placed in the apparatus body, coupled with the signal generating device, and configured for generating a RF magnetic field with a RF magnetic field characteristic which is shown to suppress an inflammatory response. The powering device is placed in the apparatus body, electrically coupled with the signal generating device, and configured for powering the signal generating device.

Vagal nerve stimulation devices and methods are provided herein. A device comprises one or more electrodes having a contact surface for contacting an outer skin surface of a patient and an energy source coupled to the electrodes. The energy source generates one or more electrical impulses and transmits the electrical impulses to the electrodes and transcutaneously through the outer skin surface of the patient at or near a vagus nerve. The one or more electrical pulses comprise bursts of 2 to 20 pulses within each burst with each burst having a frequency of about 5 Hz to about 100 Hz.