33 results about "Vagal nerve" patented technology

In an illustrative embodiment, methods and systems for treating uterine bleeding include applying, at least every other day in which a subject exhibits or is expected to exhibit menstrual bleeding, neurostimulation therapy in one or more sessions, each session having a duration of at least five minutes, the neurostimulation therapy including applying electrical neurostimulation or mechanical neurostimulation to directly and / or indirectly activate one or more neural targets, the one or more neural targets including a trigeminal cervical complex and / or vagal efferent fibers. The neurostimulation therapy may be configured to enhance platelet function of the subject, thereby reducing a total volume of blood loss over a course of the menstrual bleeding.

Disclosed is a system, a device, and a method for neuro-acoustic vagal modulation The method includes the steps of receiving (706) a session type selection, determining 5 (708) stimulation parameters, generating (710) stimulation signals, and transmitting (712) the signals to a neuro-acoustic vagal modulation device (102) positioned behind a user's ear. The method includes receiving (714) physiological response data from the device (102) or an auxiliary wearable device (108), dynamically adjusting (716) the stimulation parameters based on the received data, and transmitting (718) the adjusted 10 signals to the device (102).

This disclosure relates to medical implant systems and apparatuses capable of treating a seizure condition through the use of recording and stimulating electrodes. The apparatus includes an internal pulse generator in communication with a wireless communication module; one or more recording electrodes in communication with the internal pulse generator, wherein the one or more recording electrodes are configured to monitor to detect one or more field potentials produced by neural tissue in proximity to the one or more recording electrodes; one or more stimulating electrodes in communication with the internal pulse generator, wherein the one or more stimulating electrodes are configured to stimulate the vagus nerve.

This application discloses the application of pyridostigmine in the preparation of drugs for the prevention and treatment of non-alcoholic fatty liver disease (NAFLD). Validation was conducted using animal models of NAFLD induced by three different etiologies: methionine-choline deficiency diet, high-fat diet, and leptin gene knockout. Pyridostigmine significantly improved vagal nerve activity in the model animals (e.g., improving high-frequency and baroreflex sensitivity in heart rate variability), effectively corrected serum lipid metabolism disorders (reducing LDL cholesterol), alleviated hepatocyte damage (reducing ALT and AST), and at the histopathological level, reduced hepatic steatosis, decreased inflammatory cell infiltration, and inhibited collagen deposition, thereby achieving the prevention and treatment of NAFLD.

In an illustrative embodiment, methods and systems for treating uterine bleeding include applying, at least every other day in which a subject exhibits or is expected to exhibit menstrual bleeding, neurostimulation therapy in one or more sessions, each session having a duration of at least five minutes, the neurostimulation therapy including applying electrical neurostimulation or mechanical neurostimulation to directly and / or indirectly activate one or more neural targets, the one or more neural targets including a trigeminal cervical complex and / or vagal efferent fibers. The neurostimulation therapy may be configured to enhance platelet function of the subject, thereby reducing a total volume of blood loss over a course of the menstrual bleeding.

The invention discloses a bionic gastric mucosa micro-barrier structure, comprising: a bottom microfluidic channel for simulating a submucosal vascular network; the middle gastric epithelial cell layer is used for simulating a mucous membrane epithelial barrier and comprises a matrix layer, quaternary functional cells, a culture medium and a pH buffer module; and the surface dynamic mucus layer is used for simulating a mucous membrane protective barrier and comprises a vagus neurotransmitter simulant, exogenous mucus and a pressure sensor. According to the invention, continuous nutrition supply is provided for the middle gastric epithelial cell layer through the bottom microfluidic channel, the survival and functions of cells are maintained, and accurate tracking of the transgastric mucosa transport process is realized. A function collaborative network is formed through quaternary cells, the secretion volume and the injury state are monitored in real time, regulatory factors are dynamically adjusted, and it is ensured that a cell layer can still maintain the barrier function stable under external interference. When foreign matter impact or food friction signals are recognized through the pressure sensor, the pump speed is instantly increased, and local mucus loss is rapidly supplemented.

The disclosure relates to a system comprising a device that includes electrodes and a sensor operably connected in electrical communication with a controller housing a computer program product that calculates heart rate and mean arterial blood pressure in the circulatory system of a subject by the sensor being placed at or proximate to the cardiac tissue of the subject. Electrodes on the device stimulate the vagal nerve to restore heart rate and arterial blood pressure to normal levels if an abnormality is detected.

The presently disclosed subject matter provides for in vitro methods of inducing differentiation of stem cells into hindbrain progenitor cells, enteric neural crest lineage cells, as well as differentiated hindbrain lineage or enteric neural crest lineage cells obtained by such methods. The presently disclosed subject matter also provides for uses of such cells for preventing and / or treating enteric nervous system disorders (e.g, Hirschsprung's disease), and for screening compounds suitable for preventing and / or treating enteric nervous system disorders (e.g., Hirschsprung's disease).

Methods and apparatuses for treating a senescence related disease, disorder, or pathological condition. These methods may include identifying a cellular senescence status in a senescence related disease, disorder, or pathological condition in a subject; and treating the subject for the senescence-related disease, disorder, or conditional by vagal nerve stimulation.

In an illustrative embodiment, methods and systems for treating fertility conditions in women diagnosed with polycystic ovary syndrome (PCOS), endometriosis, and / or adenomyosis using electrical neurostimulation include delivering neurostimulation therapy via electrical or mechanical stimulation elements, the neurostimulation therapy including applying first neurostimulation pulses using electrical neurostimulation or mechanical neurostimulation at one or more first regions of skin of the subject to directly and / or indirectly activate a nucleus tractus solitary (NTS) and / or a trigeminal cervical complex (TCC) to activate anti-inflammatory pathways, and applying second neurostimulation pulses using electrical neurostimulation or mechanical neurostimulation at one or more second regions of skin of the subject to directly and / or indirectly activate vagal neural fibers and / or trigeminal neural fibers, wherein the neurostimulation pulses are configured to increase a parasympathetic / sympathetic (P / S) ratio.

Disclosed is a system, a device, and a method for neuro-acoustic vagal modulation. The method includes the steps of receiving (706) a session type selection, determining (708) stimulation parameters, generating (710) stimulation signals, and transmitting (712) the signals to a neuro-acoustic vagal modulation device (102) positioned behind a user's ear. The method includes receiving (714) physiological response data from the device (102) or an auxiliary wearable device (108), dynamically adjusting (716) the stimulation parameters based on the received data, and transmitting (718) the adjusted signals to the device (102).

The invention discloses a psychological intervention method of a wearable relaxation device, the wearable relaxation device comprises a wearable waistcoat and a headgear, the front and back of the wearable waistcoat are both provided with a heating sheet and an air bag, and the headgear is internally provided with an ultrasonic generator; a user wears the head sleeve on the head of the waistcoat; an ultrasonic generator emits audio stimulation of specific brain wave guiding components, brain activities of a treated individual are guided to a deep relaxation or semi-sleep state mainly including alpha waves (8-12 Hz) and theta waves (4-8 Hz), and dominant defense and high-alertness reactions are reduced; by means of linguistic or audio meditation guidance, establishment of a safety scene is assisted, excessive activation of sympathetic nerves is reduced, and vagus nerve dominance is improved; the obvious improvement in the aspects of sleep, emotion, self value feeling and the like can be observed in 7-14 days; the original energy feeling is reprogrammed through a multi-layer path, the deep subconsciousness is changed, and the recurrence probability is low.

The invention discloses a brain earphone interface device, and relates to the technical field of auricular point treatment, the brain earphone interface device comprises an electroencephalogram collector, the rear side of the electroencephalogram collector is fixedly connected with a controller, the electroencephalogram collector is electrically connected with the controller, the bottom of the controller is fixedly connected with a wire, the tail end of the wire is fixedly connected with two earphones, and the two earphones are electrically connected with the controller. The controller is electrically connected with the earphone through a wire. An electroencephalogram signal of a user is collected through an electroencephalogram collector, and then the current state of the user, such as a fatigue state, a depression state and the like, is recognized according to cooperation of a collection module and a controller; then according to the current condition of the user, refreshing music is selectively played through the player or the first electrode slice and the second electrode slice are matched to stimulate the ear vagus nerve of the user for treatment, and compared with traditional pure active auricular point treatment, real-time treatment is carried out in cooperation with electroencephalogram signals, the treatment effect is better, and use is more convenient.

Provided herein are methods for treating autism; and systems and devices for administering transcutaneous auricular vagal nerve stimulation (taVNS).

1. The name of the design product: ear vagus nerve stimulation electrode. 2. The use of the design product: for the auxiliary treatment of mental illness and nerve rehabilitation. 3. The design points of the design product: in the overall shape of the product. 4. The picture or photo that best indicates the design points: perspective view.

1. The name of the design product: ear vagus nerve stimulation electrode. 2. The use of the design product: for the auxiliary treatment of mental illness and nerve rehabilitation. 3. The design points of the design product: in the overall shape of the product. 4. The picture or photo that best indicates the design points: perspective view.

In an illustrative embodiment, methods and systems for treating uterine bleeding include applying, at least every other day in which a subject exhibits or is expected to exhibit menstrual bleeding, neurostimulation therapy in one or more sessions, each session having a duration of at least five minutes, the neurostimulation therapy including applying electrical neurostimulation or mechanical neurostimulation to directly and / or indirectly activate one or more neural targets, the one or more neural targets including a trigeminal cervical complex and / or vagal efferent fibers. The neurostimulation therapy may be configured to enhance platelet function of the subject, thereby reducing a total volume of blood loss over a course of the menstrual bleeding.

The disclosure provides systems and methods for automatically titrating an electrical pulse amplitude for a patient-implanted VNS stimulator. One or more external sensors (e.g., EEG, EKG, EMG, auditory sensors, inertial motion sensors, etc.) can be applied to the patient to generate data relevant to an acceptable amplitude of the electrical pulse for a given cathode in a multi-cathode cuff. In one embodiment, the device may include a controller on the implanted VNS stimulator that receives data, e.g., using a wireless connection, from the external sensors and titrates upward the amplitude until an acceptable amplitude is determine that provides efficacy with minimal, if any, side effects.

A method and eyewear apparatus for reducing visual triggers during vascular access or interventional procedures or other medical procedures or treatments. One method uses a vision-restricting eyewear apparatus comprising a lens with an opaque lower region and an affixed compressible foam pad that together obstruct the subject's lower field of vision while preserving partial forward or upward visibility. When worn, the apparatus forms at least a substantially continuous, gapless visual barrier that limits exposure to procedural stimuli for effective blocking. The method and apparatus aim to reduce physiological and psychological distress, including vasovagal responses. In one non-limiting embodiment, a vision-restricting apparatus and associated method are provided for reducing visual triggers during vascular access, breast biopsy, or other interventional procedures. The apparatus includes a lens or eyeshield having an opaque lower region configured to obstruct the user's inferior visual field while preserving forward or upward visibility through a transparent upper region. Affixed along the lower edge of the lens is a compressible, skin-safe foam or other interface that deforms by folding or bending against itself, forming a continuous, gapless visual barrier that conforms to a variety of facial anatomies. In some embodiments, the apparatus comprises a single continuous lens or eyeshield body or discrete lenses for each eye, and may further include a support frame or adhesive interface for facial adhesive of the apparatus to a patient. The method comprises applying the apparatus immediately prior to a needle-based or image-guided procedure to position the visual obstruction in place, thereby reducing physiological or psychological distress—such as vasovagal responses—by blocking distress-inducing stimuli within the lower visual field. The apparatus is suitable for single-use disposable application.

A method and an apparatus for facilitating stimulating of vagal nerves in a neck region of a user by utilizing pulsed short-wave therapy technology for purposes of treating chronic inflammation throughout a body of the user. The apparatus includes an apparatus body, a signal generating device, a field generating element, and a powering device. The apparatus body is configured to be placed on a part of the body. The signal generating device is placed in the apparatus body and configured for generating a signal with a signal characteristic. The field generating element is placed in the apparatus body, coupled with the signal generating device, and configured for generating a RF magnetic field with a RF magnetic field characteristic which is shown to suppress an inflammatory response. The powering device is placed in the apparatus body, electrically coupled with the signal generating device, and configured for powering the signal generating device.

Vagal nerve stimulation devices and methods are provided herein. A device comprises one or more electrodes having a contact surface for contacting an outer skin surface of a patient and an energy source coupled to the electrodes. The energy source generates one or more electrical impulses and transmits the electrical impulses to the electrodes and transcutaneously through the outer skin surface of the patient at or near a vagus nerve. The one or more electrical pulses comprise bursts of 2 to 20 pulses within each burst with each burst having a frequency of about 5 Hz to about 100 Hz.

The present invention belongs to the field of prebiotic functional chocolate preparation, and discloses an anti-fatigue functional chocolate and a preparation method thereof, the chocolate is prepared by using cocoa butter as a matrix, adding DP3-DP6 isomaltooligosacharide and a chitosan oligomer with a molecular weight of 1000-3000 Da and a deacetylation degree of 80%-95%, and adopting a low temperature dispersion process, a 28 DEG C and 14 DEG C temperature regulation crystallization process and a mold curing process. The prepared product is fermented by probiotics in colon to generate short-chain fatty acid, the short-chain fatty acid activates intestinal-brain axis through blood and vagus nerve, central serotonin level is improved, and central fatigue is relieved; meanwhile, the short-chain fatty acid activates an AMPK signal channel, enhances the muscle mitochondrial function, promotes fatty acid oxidation, delays lactic acid accumulation and realizes peripheral muscle energy metabolism optimization. The low-temperature dispersion and temperature-regulating crystallization process not only protects functional components, but also keeps the smooth taste of the chocolate.

Methods and apparatuses (e.g., devices and systems) for securely accessing, activating and / or updating vagus nerve stimulators. In particular, described herein are methods and apparatuses for securing providing, verifying and / or executing digital prescriptions for implantable (including implanted) vagus nerve stimulation systems that may be used for treating inflammation. These methods and apparatuses (including software and / or firmware) may be adapted for used with low-energy requirements of the implanted components.

The application discloses a kind of based on motor imagination and collaborative stimulation brain-computer interface rehabilitation training system and method.The system includes signal acquisition module, data processing module and collaborative stimulation module.Data processing module is based on affine invariant riemannian metric and Transform model according to the multi-channel electroencephalogram signal of acquisition, generates movement intention decoding result and trigger signal;Collaborative stimulation module responds to trigger signal, drives functional electrical stimulation and vagus nerve stimulation unit to execute synchronous stimulation, constitutes closed-loop rehabilitation training.The core lies in that decoding unit is reduced by dimension to electroencephalogram signal by based on affine invariant riemannian distance unsupervised clustering, then input Transform model classification, in combination with the double verification mechanism of trigger control unit, realize high-precision intention decoding and reliable trigger.The present application accurately synchronizes central nervous regulation and peripheral muscle feedback, effectively improves the neural remodeling efficiency and system generalization ability of motor function rehabilitation.

Example devices and techniques are disclosed for delivering neurostimulation therapy transesophageally. An example device includes stimulation circuitry configured to generate a transesophageal stimulation signal. The example device includes memory configured to store stimulation parameters that at least partially define the transesophageal stimulation signal and processing circuitry communicatively coupled to the memory, and the stimulation circuitry. The processing circuitry is configured to determine a maximum transesophageal stimulation amplitude value. The processing circuitry is configured to control the stimulation circuitry to generate the transesophageal stimulation signal based at least in part on at least one of the stimulation parameters or the maximum transesophageal stimulation amplitude such that an amplitude of the transesophageal stimulation signal does not exceed the maximum transesophageal stimulation amplitude.

The invention relates to an ear walking electrical stimulator which comprises a control module and a stimulation piece capable of being worn in an ear, the stimulation piece comprises a base body and a first electrode tip arranged on the base body, the control module is in electric signal connection with the first electrode tip, the ear walking electrical stimulator further comprises a second electrode tip arranged on the base body, and the second electrode tip is in electric signal connection with the first electrode tip. And a heating piece is embedded in the second electrode tip and is in electric signal connection with the control module. The ear strake electrical stimulator reduces the skin resistance in the ear, and further improves the vagus nerve stimulation effect. The invention further relates to a working method of the ear-walking electrical stimulator and a storage medium, and computer programs / instructions for realizing the working method of the ear-walking electrical stimulator when the computer programs / instructions are executed by the processor are stored on the storage medium.

A facial cold plunge device designed to enable prolonged and effective facial immersion in cold water for therapeutic, cosmetic, and wellness purposes. The device comprises an insulated housing unit with an ergonomically contoured reservoir, a chilling mechanism to maintain water temperatures below 50° F., and a thermostat-controlled interface for precise temperature adjustment. A closed-loop water circulation system, incorporating a filtration assembly, ensures consistent cooling and hygienic water conditions. The invention features a retractable breathing apparatus with a snorkel-like tube and a two-way check valve, allowing users to sustain facial submersion without interrupting respiration. The compact and portable design, combined with integrated chilling, filtration, and respiratory support systems, provides a convenient, efficient, and accessible solution for cold therapy, addressing the limitations of traditional full-body cold plunges and DIY facial immersion methods. Applications include stress reduction, vagus nerve stimulation, inflammation control, and various cosmetic benefits.

1. The name of the design product: nerve electrical stimulator (handheld). 2. The use of the design product: the design product is used for stimulating vagus nerve. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

A dual-sensor bone-conduction system enables real-time theranostic monitoring of vagal, vascular, and neuro-physiological activity through simultaneous acoustic fingerprinting and bio-impedance spectroscopy. A bone-conduction transducer transmits frequency-swept mechanical energy (32 Hz-1 MHz) while a piezoelectric receiver and tetrapolar electrodes capture reflected and dielectric responses. Machine-learning fusion of these signals yields indices of vascular resonance, mechanical-electrical coherence, and bilateral autonomic symmetry. Embodiments include cranial EEG-type headsets, thoracic ECG-type modules, smartwatches, veterinary collars, and plant-stress sensors. The system supports diagnostic imaging, closed-loop acoustic neuromodulation, and cross-species health or stress detection in a low-power, wearable, and non-invasive form factor.

The disclosure relates to a method of operating a wearable electronic stimulation device. The method can include providing and arranging the wearable electronic vagus nerve stimulating (VNS) device and applying vagus nerve stimulation using the VNS device. The method can also include monitoring and recording a user's physical symptoms and providing to the user behavior instructions. The method can also include combining the vagus nerve stimulation with the monitored and recorded physical symptoms, and / or the behavior instructions to generate a personalized treatment plan for managing the user's chronic pain.