This invention relates to the field of biomedical materials technology, and more particularly to a flexible patch for treating
nervous system diseases and its preparation method. It comprises: a flexible, breathable substrate composed of silk
fibroin nanofibers, and
drug-loaded nanoparticles loaded within the substrate; the
drug-loaded nanoparticles are encapsulated with
chitosan and contain
levodopa and
copper oxide nanoenzymes; the silk
fibroin nanofibers are annealed with
ethanol to form a controllable degradation structure, achieving self-adhesion and continuous
drug release in a humid environment. This patch can simultaneously achieve stable delivery of
dopamine and
scavenging of
reactive oxygen species, thus addressing the motor complications and neurooxidative damage caused by fluctuations in
blood drug concentration in traditional Parkinson's
disease treatment, achieving a dual synergistic treatment of
symptom relief and
neuroprotection.