21 results about "Sucralose" patented technology

The application discloses application of T1R3 agonist sucralose in relieving Alzheimer's disease and related cognitive impairment, and aims at brain glucose metabolism disorder and cognitive decline problem, and the application takes sucralose as the only pharmaceutical active ingredient, corrects brain glucose metabolism disorder through targeting brain astrocyte sweet taste receptor T1R3, and then treats and relieves neurodegenerative diseases. The application is proved by animal experiments that cognitive dysfunction of AD model mice can be improved in a full range of molecular mechanisms, cell functions, tissue metabolisms and whole behavior, and a variety of dosage forms and medication strategies can be selected, and the application has good in-vivo safety and clinical transformation potential.

To provide a taste-modifying composition that reduces the saltiness of sodium salts, such as sodium bicarbonate; the use of such a taste-modifying composition to reduce the saltiness of sodium salts; and a composition (such as an edible composition or an oral care composition) comprising a sodium salt and a taste-modifying composition. [Solution] below: (a) Glucosylated natural steviol glycoside; (b) 4-amino-5,6-dimethylthieno[2,3-d]pyrimidine-2(1H)-one or a salt thereof; (c) sucralose; and (d) Oxacyclohexadecane-2-one A taste-modifying composition comprising two or more combinations of the following.

A process for preparing an aqueous ready to use oral liquid suspension of zonisamide or pharmaceutically acceptable salts thereof, wherein the process comprises: (a) adding purified water into a vessel; (b) adding a mixture of microcrystalline cellulose and carboxymethylcellulose sodium with stirring; (c) adding xanthan gum with stirring; (d) adding citric acid and sodium citrate with stirring; (e) adding sodium benzoate with stirring; (f) adding sucralose with stirring; (g) adding zonisamide or pharmaceutically acceptable salt thereof, with stirring at 20-30 Hz for 10-60 minutes; (h) stirring the suspension at 30-40 Hz for 45-55 minutes; (i) stirring the suspension at 45-55 Hz for 10-15 minutes; (j) adding strawberry flavouring with stirring; (k) adding purified water to make up the final volume; and (l) stirring the suspension, is provided. The process may further comprise (m) transferring to a filling vessel; and (n) packing the final suspension into a container. A sodium vapour lamp may be used before step (g). An aqueous ready to use oral liquid composition prepared by the process is provided. [Fig: None]

This invention provides a traditional Chinese medicine oral gel for relieving wind-cold, clearing the lungs, stopping cough, and soothing the throat, along with its preparation method. After combining the thick pastes, an impurity removal process is added, followed by refrigeration for at least 48 hours to remove some impurities and reduce the solid content. Then, by selecting 1.0%-2.5% xanthan gum as a matrix, and using 0.1%-0.2% Gannan orange flavoring and 0.2%-0.3% sucralose to form a complex flavoring system, and controlling the parameters during homogenization, this invention effectively solves the problems of poor gelation and instability in oral gel formulations. It also overcomes the bitter taste caused by the acidic and astringent odor of the drug extract and volatile oils. This invention features convenient administration, safety and effectiveness, good taste, and superior formulation stability, improving compliance for children and the elderly. The entire preparation method is simple and suitable for large-scale industrial production.

The invention discloses application of recombinant human glaze matrix protein in preparation of an anti-periodontitis oral care product. The oral care product is prepared from rhEMPs, glycerin, sorbitol, poloxamer 188, sodium lauroyl sarcosinate, potassium nitrate, sucralose, xylitol, methylparaben, propylene glycol, PEG-40 hydrogenated castor oil, domiphen and water. The core innovation of the oral care product is that the stability bottleneck of rhEMPs in the physiological pH environment of the oral care product is solved by utilizing the synergistic stabilization effect of poloxamer 188 and sodium lauroyl sarcosinate, and it is found that when the oral care product is combined with components such as potassium nitrate, periodontal pathogenic bacteria can be remarkably inhibited, gingival inflammation can be relieved, and periodontal tissue repair can be promoted. The product form can be mouth wash, oral spray or toothpaste, the preparation process is simple, the stability is good, and a brand new solution is provided for daily adjuvant therapy of periodontitis.

The application discloses a preparation method of sucralose-6-ethyl ester. The method comprises the following steps: under the action of a supported catalyst, sucrose-6-ethyl ester and hexachlorocyclohexa-2,5-dienone are subjected to selective chlorination reaction in a solvent to generate sucralose-6-ethyl ester. The method has simple process and mild conditions, avoids the use of phosgene and thionyl chloride, greatly simplifies the post-treatment process, reduces energy consumption, and is easy to separate the used supported catalyst and environment-friendly.

This invention provides a plant-based composition comprising a first component, a second component, and a third component. The first component comprises 1-3 parts by weight of protein melanin and 1-3 parts by weight of phenylethanoid glycoside. The second component comprises 10-14 parts by weight of Polygonatum sibiricum powder, 8-12 parts by weight of licorice powder, 8-12 parts by weight of wolfberry powder, 8-14 parts by weight of longan powder, 8-16 parts by weight of jujube powder, 12-15 parts by weight of Poria cocos powder, and 7-10 parts by weight of red rose powder. The third component comprises 3-5 parts by weight of γ-aminobutyric acid (GABA), 2-6 parts by weight of erythritol, 3-5 parts by weight of citric acid, 2-4 parts by weight of sucralose, and 3-5 parts by weight of ascorbic acid. This invention uses protein melanin and phenylethanoid glycoside as the main active ingredients, supplemented with Polygonatum sibiricum powder, Poria cocos powder, and GABA. Experiments have shown that this composition can prolong the swimming time of mice under load and improve their lymphocyte proliferation capacity. This composition can regulate bodily functions and enhance immunity.

This invention provides a method for preparing a bifunctional mesoporous solid acid catalyst and its application in the hydrolysis of cellulose to produce glucose. Using alkali lignin as the carbon source and sucralose as the chlorine source, the bifunctional mesoporous solid acid catalyst is obtained after high-temperature carbonization and concentrated sulfuric acid sulfonation. This catalyst not only possesses a high density of -SO3H groups, enabling efficient cleavage of cellulose glycosidic bonds, but also exhibits -Cl groups that can form hydrogen bonds with cellulose, enhancing the catalyst's adsorption capacity for cellulose polysaccharides. When the prepared catalyst is used for cellulose hydrolysis, it can efficiently convert cellulose into glucose at a temperature of 150–190 °C for 2–6 h. It exhibits advantages such as high catalytic efficiency, few byproducts, and low corrosiveness to equipment, making it an environmentally friendly solid acid catalyst.

The application provides a method for obtaining sucralose, and relates to the technical field of chemical production, and comprises the following steps: (1) removing part of the solvent from a sucralose waste liquid by rotary evaporation, mixing with water, and then performing fractional extraction, and obtaining a concentrate and butyl acetate by rotary evaporation, and cooling the concentrate to crystallize to obtain a solid crude product and a mother liquor; (2) performing fractional recrystallization on the solid crude product to obtain a crystallization mother liquor and sucralose solid with a purity of 90-99%. The method can effectively recover sucralose from the sucralose waste liquid, and realizes the resource utilization of waste.

This utility model relates to the field of waste heat recovery technology, specifically a waste heat recovery and utilization device for sucralose, including an inlet tank, a heat exchange tank, and an outlet tank. A cool water outlet pipe is connected to the outlet tank. The top and bottom surfaces of the heat exchange tank are respectively connected to a mother liquor inlet pipe and a mother liquor outlet pipe. The mother liquor outlet pipe is vertical and connected to an upper horizontal pipe closed at both ends. The upper horizontal pipe is connected to a first vertical pipe and a second vertical pipe. A filter screen is installed inside the first vertical pipe, and its other end is connected to the reactor inlet pipe. The first vertical pipe is detachably connected between the upper and lower horizontal pipes. Valves are installed on both sides of the mother liquor outlet pipe on the upper horizontal pipe. By using a fixed scraper and a rotatable heat exchange tube, the surface of the heat exchange tube can be cleaned during rotation, removing blockages and ensuring heat exchange efficiency. Simultaneously, after cleaning away the crystals, they can be removed to prevent them from entering the reactor and affecting its normal reaction.

The present application relates to sucrose crystallization technical field, and disclose a forced circulation crystallizer for trichloro sucrose mother liquor, including rack, the rack is installed with crystallization kettle and mother liquor tank, the filter assembly is provided in the mother liquor tank, the filter assembly includes mounting frame, the mounting frame is fixed in the inside of mother liquor tank, and the side surface of mounting frame is combined with the inner face of mother liquor tank, two rotating shafts are rotatably installed on the mounting frame, and the two rotating shafts are located at the two ends of mounting frame respectively, the roller is fixedly sleeved on each rotating shaft, and the two rollers are drivenly connected by filter membrane, the filter assembly further includes motor, and the motor is installed on the side surface of mother liquor tank.The present application works, the filter membrane under the motion state makes the mother liquor flow through different areas uniformly by continuous movement, avoids local blockage, and the impurities are uniformly dispersed on the membrane surface, the effective filtering area is expanded and the service life of single point is prolonged, and the vibration or water flow scouring effect promotes the impurities to fall off.

The disclosure is directed to stabilized aqueous compositions containing calcium (in the form of calcium lactate and calcium gluconate), vitamin D3, and vitamin K2. In addition to calcium, vitamin D3, and vitamin K2, the compositions contain an emulsifier (such as e.g., a polysorbate), an antioxidant (such as e.g., ascorbic acid) and one or more of a sweetener (such as e.g., sucralose and sorbitol), a preservative, a flavoring agent, a pH adjuster, or a combination thereof. The disclosure also includes using the compositions to support bone health.

The application discloses a maraviroc dry suspension and a preparation method thereof, which comprises the following steps: uniformly mixing maraviroc, mannitol, maltitol, sodium chloride, povidone K25 and polyvinyl alcohol, wet granulating, drying, and whole granulating, and then mixing with colloidal silicon dioxide, sucralose, talcum powder and strawberry flavor, and filling to obtain the maraviroc dry suspension. According to the optimized prescription process, the suspension uniformity and the anti-settling capacity of the maraviroc dry suspension can be remarkably improved, the problems of the traditional dry suspension, such as easy stratification and inaccurate dosage, can be effectively solved, the total impurity content of the prepared maraviroc dry suspension is low during storage, the impurity growth is slow, and the chemical stability is better than that of a commercial sample, so that the drug has good quality and stable curative effect within the effective period, and the preparation method is simple in operation, suitable for industrial production, and has a wide application prospect.

This invention discloses a dual-enzyme anhydrous compounded acid-base rapid-disintegration porous toothpaste, belonging to the field of oral care product technology. The toothpaste is composed of the following raw materials: 9.0 parts sodium bicarbonate, 4.5 parts anhydrous citric acid, 6.0 parts crospovidone, 27.5 parts microcrystalline cellulose, 1.5 parts embedded complex biological enzyme, 3.5 parts powdered sodium lauroyl sarcosinate, 1.5 parts powdered sodium cocoyl glutamate, 22.0 parts spherical micro-powdered hydrated silica, 0.75 parts sodium monofluorophosphate, 1.5 parts anhydrous sodium pyrophosphate, 7.0 parts low-hygroscopic sorbitol, 0.2 parts sucralose, 0.8 parts pre-adsorbed peppermint flavor, 0.75 parts magnesium stearate, and 0.5 parts powder-embedded phenoxyethanol. This invention utilizes an anhydrous powder formulation design, taking advantage of the synergistic disintegration effect of an acid-base effervescent system and cross-linked polyvinylpyrrolidone, combined with the chemical decomposition of plaque biofilm by microencapsulated dual enzymes, to achieve rapid disintegration of the lozenge in the mouth and release of micro-nano bubbles. It can complete oral cleaning without the need for toothbrush friction, and is characterized by being gentle, portable, rapid disintegration and leaving no residue.

The application discloses a kind of homoeopathy cydonia drink for preventing alcoholic gastric mucosal injury and preparation method and quality control method thereof, belong to functional food technical field.Each 1000 weight parts of the homoeopathy cydonia drink, the following weight parts of raw materials are included: cydonia peel extract 2-10 parts, arabinose 50-150 parts, sucralose 6-14 parts, malic acid 0.2-0.8 parts, potassium sorbate 0.1-0.3 parts, magnesium gluconate 0.6-1.0 parts, zinc gluconate 0.01-0.05 parts, carbon dioxide 4-6 parts, the rest is water.The application is by constructing cydonia peel extract and organic zinc magnesium and non-calorie compound sweetener synergic system, gradient temperature coupling ultrasonic assisted extraction process is combined, while effectively removing bitterness and retaining active ingredients, low glycemic index and synergistic protective effect to gastric mucosa are realized.

This invention relates to the field of flavor technology, and particularly to an aerosol matrix composition and atomizing liquid. The aerosol matrix composition comprises lactic acid, leaf alcohol, raspberry ketone, butyric acid, and sucralose. In the technical solution provided by this invention, lactic acid and butyric acid are used as acidulants to stimulate salivary gland secretion; leaf alcohol and raspberry ketone are used as flavoring agents to enhance flavor perception and influence saltiness perception, making the saltiness more natural; sucralose is used as a sweetener to provide sweetness, and simultaneously works with the acidulants so that taste receptors in the oral cavity receive both sweet and sour signals, stimulating the salivary glands to secrete more saliva and amplifying the saltiness. Furthermore, the coexistence of sweetness and saltiness, with an appropriate amount of sweetness highlighting the saltiness, further enhances the saltiness sensation.

This invention belongs to the field of food ingredient technology and discloses a low-sugar, moisture-resistant sugar powder, comprising the following components by weight: 83 parts of low DE-value solid corn syrup and polydextrose, wherein polydextrose accounts for 10% to 30% of the 83 parts by weight, and the remainder is solid corn syrup; 0.04 to 0.06 parts of sucralose; 0.08 to 0.12 parts of sodium citrate; 9 to 11 parts of vegetable oil; 0.3 to 0.5 parts of mono- and diglycerides of fatty acids; 0.3 to 0.5 parts of fumed silica; and 6.0 to 7.0 parts of hydroxypropyl distarch phosphate. The preparation method is also disclosed. The preparation process of this invention is simple, can be continuously produced, and the prepared product has uniform powder, excellent flowability, strong moisture resistance, and is suitable for industrial production.

This invention relates to the field of health food and pharmaceutical preparation technology, specifically a method for preparing freeze-dried flash-release tablets of deer antler extract. The freeze-dried sustained-release tablets of deer antler extract are made from the following raw materials in the indicated weight ratios: 3-5 parts deer antler extract, 8-10 parts matrix support agent, 2.0-3.0 parts binder, and 0.4-0.6 parts flavoring agent. The method includes the following steps: S1, ingredient dissolution; S2, high-speed emulsification; S3, vacuum degassing; S4, quantitative filling; S5, ultra-low temperature quick-freezing; S6, programmed freeze-drying; S7, aluminum-aluminum sealed packaging. The invention achieves a breakthrough in taste: through the synergistic effect of sucralose (a high-intensity sweetener) and strawberry flavoring, the fishy and astringent taste of deer antler is successfully masked, transforming it from "difficult to swallow" to "pleasantly acceptable." It is convenient to take: no water is required, solving the privacy issue for male users taking it in specific situations. The efficacy is rapidly released: the freeze-dried tablets disintegrate quickly, facilitating the rapid absorption of active ingredients.

The application provides a process for recovering sucralose hexaester from trichloroethane in tail gas of sucralose, and belongs to the field of food additive production.The process method of the application is that first, impurities such as sulfur dioxide in total trichloroethane are removed to obtain relatively pure trichloroethane, then the trichloroethane is subjected to neutralization treatment and extraction of sucralose hexaester, so that the problem of difficult recovery of sucralose hexaester after water washing of total trichloroethane in tail gas of a chlorination section is solved, the recovery rate of sucralose hexaester is high, the consumption of sucralose hexaester is reduced, the cost is saved, and the discharge is reduced.

This invention discloses a bergamot effervescent tablet based on microencapsulation technology and its preparation method, relating to the field of solid beverage technology. The invention comprises, based on a total feed weight of 100 kg, the following components: bergamot extract; 3 kg; anhydrous citric acid; 18 kg; sodium bicarbonate; 15 kg; dextrin; 45 kg; gum arabic; 0.6 kg; tragacanth gum; 0.15 kg; taurine; 1.58 kg; zinc gluconate; 0.75 kg; zinc citrate; 0.25 kg; calcium gluconate; 0.25 kg; ascorbic acid C; 0.1 kg; ferrous gluconate; 0.11 kg; thiamine hydrochloride; 0.058 kg; riboflavin; 0.03 kg; pyridoxine hydrochloride; 0.02 kg; cyanocobalamin; 0.001 kg; folic acid; 0.001 kg; isomaltitol; 15 kg; sucralose; 0.1 kg. The advantages are: through systematic screening of key factors such as the inclusion of aromatic oil components in bergamot extract, the ratio of acid-base disintegrants, the ratio of flavoring agents and food fortifiers, the type of fillers, the preparation method of acid-base particles, and the tableting process parameters.