1738results about How to "High yield" patented technology

The invention discloses a method for preparing a single-layer tungsten diselenide nanoband based on a space confinement strategy. By changing the flow and the growth time of hydrogen, effective control on the width and the thickness of a nanoband can be realized. The method comprises the following steps: uniformly spraying tungsten trioxide powder to one substrate, then covering the substrate by the other substrate, and forming micro reaction space which is of a 'sandwich'-like structure. Growth of a tungsten diselenide nanoband is carried out by utilizing a constant-pressure chemical vapor deposition method; physicochemical characteristics of a one-dimensional transition metal chalcogenide strongly depend on suspension key types on the edge of the one-dimensional transition metal chalcogenide, metallic properties are displayed by an ultranarrow band, and conversion from the metallic properties to semiconductor properties can be displayed from the edge to the center of a wider band; the tungsten diselenide nanoband is widely applied to micro-nano photoelectric devices due to the special property; industrial production of the tungsten diselenide nanoband can be realized through an experimental method of the invention.

The invention discloses a novel synthetic method for 5-phenyl tetrazole, which includes the following steps: firstly performing acid neutralization to hydrazine hydrate; then adding mixing solution formed by cyanobenzene, water and ethyl alcohol to generate phenyl aminoguanidine salt; adopting sodium nitrite for diazotization to obtain nitrine amidine under the acidic condition; obtaining 5-phenyl tetrazole crude product through closed loop under the alkaline condition; obtaining 5-phenyl tetrazole acceptable product through adopting ethyl alcohol for refining. The method has the advantages of simple technology, simplicity in operation and high product yield.

The invention discloses a synthetic method of a water soluble ultraviolet light absorber BP-9. The method mainly comprises the following process steps: (1) carrying out methylation on the main raw materials of 2, 2', 4, 4'-tetrahydroxyl benzophenone, a transition metal salt catalyst and a mixed solvent which is prepared from dichloroethane and anhydrous ethanol in equal parts by weight to obtain 2, 2'-dihydroxyl-4, 4'-dimethoxyl benzophenone; (2) carrying out sulfonation reaction on the main raw materials of methylate, sulfamic acid and C1-C3 halohydrocarbon to obtain 2, 2'-dihydroxyl-4, 4'-dimethoxyl benzophenone-5, 5'-disulfonic acid; and (3) carrying out neutral reaction on the main raw materials of sulfonated product, inorganic base and ethanol water to finally obtain the BP-9 product. The synthetic method disclosed by the invention is few in reaction step, low in cost, high in product purity and stable in quality, and raw materials are easily available.

The invention discloses a rare-earth metal arylamine group compound as well as preparation method and application thereof. The invention discloses the rare-earth metal arylamine group compound which is characterized in that a general formula of the rare-earth metal arylamine group compound is (2,6-R12PhNH)5LnLi2(THF)2, wherein Ln is a rear-earth metal selected from one of neodymium, samarium, ytterbium or yttrium; R1 is selected from one of hydrogen, methyl or isopropyl. The rare-earth metal arylamine group compound has the advantages that the rare-earth metal arylamine group compound has a definite structure; raw materials used in the preparation method are simple, easily obtained and cheap; the reaction process is simple and easily operated; the rare-earth metal arylamine group compound product is conveniently purified and the yield of the product is high; the rare-earth metal arylamine group compound has a high activity when acting as a single component catalyst to catalyze a hydrogen phosphine reaction of aldehyde or ketone and phosphite ester; the use amount of the catalyst is less; the yield is high; a substrate has wide universality; a new and simple method is provided for synthesis of a-hydroxyphosphonate.

The invention discloses a preparation process of berberine hydrochloride, and belongs to the technical field of berberine production. The invention relates to a berberine hydrochloride preparation process, which comprises: S1, mixing a ferric sulfate-aluminum sulfate composite salt, sodium chloride, zinc chloride and anhydrous formic acid, pre-activating, adding N-2, 3-dimethoxybenzyl homopiperony lamine hydrochloride, dropwise adding a glyoxal mixed solution, and carrying out a reflux reaction. And S2, cooling the reaction liquid until a solid is separated out, filtering, adding a filter cake and diatomite into purified water, stirring, adjusting alkali, heating, and continuously stirring for 0.5-1 hour. Cooling and filtering, and reserving filtrate; s3, adjusting the acidity of the filtrate, cooling and growing crystals; and filtering, rinsing a filter cake, and carrying out vacuum drying on the filter cake to obtain berberine hydrochloride. The berberine hydrochloride prepared by the method is high in yield and purity, and the preparation process is safe, short in flow and friendly to human bodies and environment.

This invention belongs to the field of biopharmaceuticals and provides a keratin YK93-6, its encoding nucleic acid molecule, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or whose genome integrates the nucleic acid molecule, as well as a preparation method and a pharmaceutical composition thereof. It also provides the application of the above-mentioned keratin YK93-6 and other products in the preparation of drugs for treating benign prostatic hyperplasia, lymphoma, melanoma, analgesia, lactation, breast cancer, lung cancer, uterine fibroids, coagulation, etc.

The invention discloses a gas-liquid atomization rotational flow mixing reaction device which comprises a mounting bracket, the mixing reaction chamber is detachably mounted on the mounting bracket through a bolt; the communicating chamber is detachably mounted at the top of the mixing reaction chamber through a bolt; the gas-liquid separation chamber is detachably mounted at the top of the communicating chamber through a bolt; the atomizing nozzle is fixedly connected to the mixing reaction chamber; the driving unit and the indicating unit are installed on the pressure regulating unit, and one end of the gas feeding pipe is fixedly connected to the atomizing nozzle. By adopting a gas-liquid atomization and rotational flow self-stirring structure, the problems that traditional mechanical stirring is slow in mixing, poor in uniformity and unbalanced in local proportion are fundamentally solved, the phenomena of back mixing and short circuit are eliminated, the reaction is more sufficient, crystallization is more uniform, the yield is higher, meanwhile, a stirring mechanism is omitted, the device is simplified, energy consumption is reduced, parameters such as pH and temperature are fed back more timely, and the production efficiency is improved. And the control precision is greatly improved.

The utility model provides a self-propelled sunflower harvester, which belongs to the technical field of agricultural machinery and structurally comprises a self-propelled vehicle machine and a frame, a header is arranged at the front end of the frame, and a primary conveyor and a secondary conveyor are communicated with the rear of the header. The rear part of the secondary conveyor is communicated with a thresher; a screening mechanism is arranged below the thresher, and the screening mechanism is composed of a first-stage vibrating screen which is composed of a swinging fish scale screen and rushes backwards, and a second-stage vibrating screen which is composed of a swinging stepped dense mesh screen and rushes forwards; the screening mechanism communicates with the conveying and lifting mechanism. The conveying and lifting mechanism comprises a transverse auger and a bucket elevator. And the conveying and lifting mechanism is connected with the grain collecting hopper. The sunflower seed and sunflower disc separating device can achieve good separation of sunflower seeds and sunflower discs, the sunflower seeds and the sunflower discs are respectively conveyed in two paths during threshing, and simple and efficient threshing separation can be achieved. The threshing process is automatically completed, manpower and material resources are saved, and good harvesting and harvesting effects are achieved.

The invention relates to the technical field of fluidized beds, in particular to a fluidization coating device with pulse, stirring and double-particle triple synergy, which comprises a spray fluidized bed reactor, a fluidized bed reactor, a stirring device and a double-particle fluidized bed reactor, the gas distributor is positioned above the carrier gas inlet and is used for uniformly distributing carrier gas entering from the carrier gas inlet on the whole bed layer to form fluidized gas; the gas-liquid two-phase flow nozzle is connected with the gas supply unit and the coating liquid conveying tank and is used for atomizing the coating liquid into micron-sized small liquid drops and then spraying the micron-sized small liquid drops into the spray fluidized bed reactor; the mechanical shearing unit continuously generates local mechanical crushing on the aggregate; the pulse air inlet device is connected with the air supply unit and is used for applying periodic pulse airflow to the fluidized bed layer and breaking particle aggregation and channeling formed during initial fluidization; and the flow aiding particles and the fine powder particles to be coated jointly form a double-particle fluidization system. The problems of difficult fluidization starting, non-uniform fluidization and the like of ultrafine powder particles are solved through triple synergy of pulse, stirring and double particles.

This invention belongs to the field of biopharmaceuticals and provides a keratin YK93-9, its encoded nucleic acid molecule, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or whose genome integrates the nucleic acid molecule, as well as a preparation method and a pharmaceutical composition thereof. It also provides the application of the above-mentioned keratin YK93-9 and other substances in the preparation of drugs for treating lung cancer, lymphoma, breast cancer, melanoma, uterine fibroids, benign prostatic hyperplasia, etc.

The invention provides a low-loss bionic elastic tooth type picking table of a linear pepper harvester. The low-loss bionic elastic tooth type picking table of the linear pepper harvester comprises a header frame, a picking roller, a pull-back rolling shaft and a conveying device. The header frame, the picking roller, the back-pulling rolling shaft and the conveying device are sequentially arranged from front to back in the feeding direction; the picking roller comprises a middle rotating shaft, a cam track disc, a spring tooth and a spring tooth shaft; the middle rotating shaft is installed on the header frame, the cam track discs are installed at the two ends of the middle rotating shaft respectively, a plurality of cam grooves are distributed in the circumferences of the cam track discs, the spring teeth are installed on the spring tooth shafts, the spring tooth shafts are arranged along the circumference of the middle rotating shaft, the ends of the spring tooth shafts are embedded into the cam grooves respectively, and the ends of the spring tooth shafts are matched with the cam grooves of the cam track discs. The spring teeth do radial telescopic motion under the constraint of the cam groove when the picking roller rotates; and the rotation direction of the back-shifting rolling shaft is opposite to that of the picking roller. The line pepper picking machine can efficiently complete line pepper picking so as to improve the picking efficiency, and the phenomena of less harvesting and missing harvesting are reduced by adopting secondary callback.

The invention discloses an astragaloside synergistic type composition as well as a preparation method and application of the astragaloside synergistic type composition. Comprising the following components: 8 to 16 parts of astragaloside, 20 to 40 parts of a honeysuckle flower extract, 10 to 20 parts of L-carnitine, 0.1 to 0.5 part of selenium yeast, 3 to 8 parts of diammonium glycyrrhizinate, 5 to 15 parts of taurine, 8 to 20 parts of a fructus forsythiae extract, 2 to 7 parts of vitamin E, 12 to 32 parts of hydroxypropyl-beta-cyclodextrin, 2 to 10.5 parts of maltodextrin, 1 to 7 parts of Arabic gum, 10 to 20 parts of lactose, 1 to 3 parts of zinc gluconate and 2 to 5 parts of magnesium stearate. 1-3 parts of vitamin C, 1-5 parts of xanthan gum and 1-3 parts of lecithin. The composition has a wide application prospect in preparation of veterinary drugs or veterinary food additives.

The invention discloses a method for extracting walnut oil by a low-water-content water extraction method regulated and controlled according to viscosity change, and belongs to the field of edible oil processing. The method comprises the following steps: carrying out high-speed crushing and colloid mill grinding on shelled walnut kernels to obtain walnut pulp, adding different water contents into the walnut pulp, uniformly stirring, and measuring the viscosity change of the walnut pulp. And extracting the walnut oil from the walnut kernels by using a low-water-content water extraction method according to the viscosity change result. According to the method, the walnut oil can be efficiently prepared through a low-water-consumption water extraction method by adjusting the viscosity of the walnut pulp, the water consumption is greatly reduced, the walnut oil extraction time is shortened, and low-consumption green extraction of the walnut oil is achieved.

This invention discloses a highly efficient asymmetric synthesis method for aryl propionic acid drug molecules. The method uses racemic aldehydes as substrates and thiamine pyrophosphate-dependent enzymes as biocatalysts. Electrolysis is performed in a diaphragm-free electrolytic cell under conditions of an external redox dielectric and constant current, in a buffer salt solution and nitrogen atmosphere. This method achieves dynamic kinetic oxidation of aldehydes via bioelectrocatalysis, enabling the high-efficiency and high enantioselectivity synthesis of aryl propionic acid drug molecules. The method eliminates the need for redox agents and additives, is simple to operate, operates under mild reaction conditions, and is green and sustainable. This invention applies bioelectrocatalysis to asymmetric synthesis, providing a green and efficient new enzymatic synthetic route for the asymmetric synthesis of aryl propionic acid drug molecules, which has significant application prospects in the pharmaceutical industry.

This invention discloses a method and system for calculating the exploitable reserves of multi-layered gas reservoirs, belonging to the field of oil and gas development technology. The method includes the following steps: evaluating the dynamic reserves of multi-layered syndicated gas wells; calculating the contribution ratio of stratified production at different production times of the gas well; based on the contribution ratio of stratified production, and according to the monthly single-point stratified production splitting coefficient, calculating the daily production splitting coefficient through linear interpolation, and combining it with the daily production of the gas well to calculate the daily production of each sub-layer, and accumulating the cumulative production of each sub-layer; based on the cumulative production of each sub-layer, calculating the cumulative gas production ratio of each stratum, and combining it with the dynamic reserves calculation results of the gas well, determining the exploitable reserves of the strata. This method provides a prediction method for the exploitable reserves of multi-layered gas reservoirs. Based on the dynamic and static parameters of the gas well sub-layers and the stratified production capacity, this method calculates the exploitable reserves of multi-layered syndicated gas wells, and can effectively guide the prediction of the exploitable reserves of multi-layered gas reservoirs.

The application relates to the technical field of nanomaterial preparation, and particularly discloses a carbon nanotube preparation method based on carbon source and plasma time sequence cooperation and a carbon nanotube. In the gas phase deposition process, carbon source gas is input in a pulse mode, and a pulse type plasma is synchronously applied, wherein the carbon source input pulse and the plasma output pulse are time-differently matched, the carbon source supply window and the plasma action window form a non-fully-synchronized time sequence coupling relationship, the carbon source activation, transportation, deposition and structure reconstruction process are controlled in the time dimension, and meanwhile, the carbon source gas is introduced from a position close to the plasma action area to maintain the pulse opening and closing characteristics. The method can improve the growth selectivity of the carbon nanotube, reduce the defect density, and is suitable for controllable preparation of single-wall carbon nanotubes. The single-wall carbon nanotube with a semiconductor content greater than or equal to 83% can be prepared with high selectivity, and the product has the advantages of few defects, high purity and high yield.

This invention discloses a manufacturing process for composite 7-series aluminum alloy sheets. The composite 7-series aluminum alloy sheets are formed by laminating and rolling multiple layers of 7-series aluminum alloy sheets and multiple layers of 1-series aluminum alloy connecting plates. The 7-series aluminum alloy sheets are composed of the following components by weight percentage: Si: ≤0.22%, Cr: ≤0.23%, Fe: ≤0.35%, Cu: 2.0-3.5%, Mg: 3.5-4.5%, Zn: 6.5-10.0%, Ti: 0.015-0.2%, Zr: 0.05-0.15%, rare earth cerium alloy: 0.015-0.05%, total impurities ≤0.1%, and the remainder being aluminum. This invention uses a lamination method to roll multiple layers of 7-series aluminum alloy sheets and multiple layers of 1-series aluminum alloy connecting plates, which effectively improves plasticity, toughness, and strength. Compared with existing single 7-series materials, it has higher material strength, better impact resistance and weldability, can adapt to corrosion resistance in complex environments, and extends service life.

The invention discloses a bimetallic oxide supported catalyst as well as a preparation method and application thereof. The bimetallic oxide supported catalyst comprises a bimetallic oxide carrier and a metal active component supported on the surface of the bimetallic oxide carrier; the bimetallic oxide carrier contains a divalent metal element oxide and a trivalent metal element oxide; the divalent metal element oxide is selected from at least one of oxides of Mg, Ca, Sr, Zn and Mn; the trivalent metal element oxide is selected from at least one of oxides of Al, In, Fe, Cr and Ce; the metal active component is selected from at least one of Pd, Pt, Ru, Ni and Co; in the bimetallic oxide supported catalyst, the mass of the metal active component is 0.1-20 wt% of the mass of the metal oxide carrier.

The invention relates to a synthesis method of a 3-olefine acid ester compound. The method comprises the following steps: carrying out contact reaction on an organic phosphine ligand, a palladium compound, conjugated olefin, an alcohol compound and carbon monoxide; wherein the structural formula of the organic phosphine ligand is shown in the specification, and in the structural formula, R0 and R1 are respectively selected from hydrogen, alkyl, alkoxy, halogen or halogenated alkyl; and R2 and R3 are respectively selected from hydrogen or alkyl. The method provided by the invention has the advantages of mild conditions, no need of an acid auxiliary agent, high yield and selectivity of the generated 3-olefine acid ester compound, reduction of corrosion to a reactor, and good application prospect, and the speculation is that the electrical property of phosphorus atoms can be regulated and controlled by using the organic phosphine ligand provided by the invention, so that the reaction activity of the palladium-organic phosphine ligand catalyst is regulated and controlled, and the yield and selectivity of the 3-olefine acid ester compound are improved. Therefore, the palladium-organic phosphine ligand catalyst generated by the ligand and a palladium compound in situ can efficiently catalyze the reaction of conjugated olefin, carbon monoxide and alcohol compounds.

The application provides a chip layout method, device and readable storage medium of a multi-project wafer. The chip layout method of the multi-project wafer comprises the following steps: acquiring relevant information, arranging chips in a maximum single exposure area, comparing different chip arrangement schemes, adjusting the chips to longitudinally fill the maximum single exposure area, adjusting the maximum single exposure area to obtain a final chip layout scheme, closely arranging the final chip layout scheme in a first quadrant of the wafer, and completing an overall layout scheme by mirror processing of the chip layout scheme in the first quadrant of the wafer. The method not only optimizes the range of the single exposure area, improves the effective layout area utilization rate, and further improves the overall yield, but also adopts a central symmetric layout, facilitates chip cutting, improves the cutting efficiency, and further reduces the cost.

The application discloses a preparation method of an abacavir impurity, specifically, 2-azabicyclo[2,2,1]hept-5-en-3-one is used as raw material, and the abacavir impurity is prepared through ring opening, separation, separation, protection, reduction, deprotection, condensation, ring closure and condensation, and the application further discloses the use of the abacavir impurity prepared by the preparation method in detection and / or control of abacavir quality, and the application provides a new idea for synthesis of the abacavir impurity, the starting raw material of the synthesis method is easy to obtain, the synthesis route has mild reaction conditions, the reaction operation is safe, and the yield and purity are good, so that the preparation demand of the impurity can be met, and the application has important significance for research on the abacavir impurity.

The application discloses a preparation method of a silodosin key intermediate and belongs to the technical field of drug chemical synthesis. The silodosin key intermediate is prepared from indoline as raw material through halogenation, cyanation, N-benzoylpropylamine protection, substitution, amination, reduction and salt formation, and the silodosin key intermediate is compound 1. The synthesis line is novel, the raw reagents are easy to obtain or prepare, high-risk and high-pollution reagents are not used, the method is safe, environment-friendly, mild in reaction condition, easy and controllable to operate, the prepared silodosin key intermediate is good in purity, high in yield and high in atom utilization rate, and the industrial production problem of silodosin can be practically solved.

This invention discloses *Aphelenchus brittleus* and its applications, relating to the field of microbial technology. The strain is taxonomically named *Aphelenchus brittleus* (…). Acaulospora delicata The specimen, with accession number CGMCC NO.42100, is a *C. cristatum* NM26B that can improve the yield and quality of chives, enhance mineral nutrient absorption, and increase the expression of genes synthesizing chive-specific aroma compounds. This lays the foundation for future research and development of suitable microbial agents for the development of the chive industry.

[Problem to be Solved] To provide a novel method for producing a 2'-carbamoylalkyl-modified nucleoside having a pyrimidine base. [Solution] A method for producing a 2'-carbamoylalkyl-modified uridine compound characterized by reacting an anhydrouridine compound and an amide compound having a protected or unprotected hydroxy group in a solvent such as an ether solvent in the presence of a boron reagent, and a method for producing a 2'-carbamoylalkyl-modified cytidine compound including a step of converting a uracil base of a 2'-carbamoylalkyl-modified uridine compound into a cytosine base.

This invention discloses a high-temperature alloy with oxidation resistance under high temperature and high pressure and its preparation method. The alloy comprises, by weight percentage, C≦0.12%, Si≦1.0%, Mn≦1.00%, P≦0.04%, S≦0.04%, Cr 20-35%, Ni≧65%, Cu 0.5-2.5%, Fe≦8%, and Y≦0.25%. By adjusting the content of each element and employing a vacuum induction + electroslag remelting smelting process, the high-temperature alloy prepared exhibits excellent oxidation resistance and excellent resistance to corrosion from solutions containing nitric acid, hydrofluoric acid, sulfuric acid, hydrochloric acid, moist chlorine, hypochlorite, chlorine dioxide, ferric chloride, and copper chloride.

The application discloses a method for synthesizing tervalent tetraaryl iron porphyrin from pyrrole, aromatic aldehyde and ferrous salt, which comprises the following steps: adding anhydrous aluminum chloride, aromatic aldehyde, pyrrole and ferrous salt into DMF under stirring, and then heating and refluxing the reaction mixture for 0.5 hours under nitrogen; removing the nitrogen and continuing to heat the reaction mixture for a certain time; stopping the reaction; cooling the reaction mixture; and placing the reaction mixture at 273K overnight; and finally filtering the reaction mixture to obtain the iron porphyrin.

This method, belonging to the field of organic synthesis technology, discloses a synthetic method for aminophenylpyrazole compounds. The method employs a green and environmentally friendly synthetic route: using 4-halo-3-nitroacetophenone as a starting material, it first reacts with DMF-DMA to obtain N,N-dimethylenamine ketone compounds. Then, the obtained N,N-dimethylenamine ketone compounds are condensed with hydrazine compounds to obtain nitrophenylpyrazole compounds. Finally, the obtained nitrophenylpyrazole compounds are reduced to aminophenylpyrazole compounds in a Fe and NH4Cl system. The synthetic process does not require expensive palladium catalysts or ligands, thus avoiding the problems of heavy metal residues or heavy metal toxicity in pharmaceutical products caused by palladium catalysts in pharmaceutical processes. It also eliminates the need to remove trace metal residues from the target product. The raw materials used are abundant, inexpensive, and readily available; the reaction system is green and environmentally friendly; the operation steps and post-processing are simple; and the overall yield is high.

The application discloses a preparation method of a nitrogen-containing heterocyclic compound and an alkali metal salt of the nitrogen-containing heterocyclic compound, and steps of the preparation method of the nitrogen-containing heterocyclic compound comprise: (1) uniformly mixing trithiocyanic acid with a first solvent, introducing sulfuryl fluoride gas or adding an alkenyl sulfonyl fluoride to perform a reaction, and obtaining a crude product through a crude treatment after the reaction is finished; (2) purifying the crude product to obtain the nitrogen-containing heterocyclic compound shown in a structural formula 1; wherein R1, R2 and R3 are each independently selected from -H, -SO2F or -CH2-(CH2) n -SO2F, n is an integer selected from 1-10, and R1, R2 and R3 are not H at the same time. The preparation method of the nitrogen-containing heterocyclic compound and the alkali metal salt of the nitrogen-containing heterocyclic compound can be applied to a large amount of trithiocyanic acid in a lithium battery electrolyte, raw materials are easy to obtain, operation is simple, the yield is high, the condition is mild, the requirement for equipment is low, and the method is suitable for industrial production.

The utility model discloses a hydrogen production and hydrogenation integrated device, and relates to the technical field of hydrogen production, the hydrogen production and hydrogenation integrated device comprises an electric heater, a hydrogen-water separation device, a hydrogenation device and a passage switching assembly, the hydrogen-water separation device is used for outputting first to-be-treated hydrogen; the hydrogenation device is used for outputting second to-be-treated hydrogen; two input ends of the passage switching assembly are respectively connected with the hydrogen-water separation device and the hydrogenation device, and an output end of the passage switching assembly is connected with an input end of the electric heater; the access switching assembly is used for controlling the hydrogen-water separation device to be communicated with the electric heater, so that the electric heater performs heat treatment on the accessed first to-be-treated hydrogen; or, the hydrogenation device is controlled to be communicated with the electric heater, so that the electric heater conducts heat treatment on the accessed second to-be-treated hydrogen. Therefore, the electric heater can run all the time, the time required by cold start preheating is eliminated, and the problem that the cold start time is too long is effectively solved.