54 results about "Clostridia" patented technology

A novel clostridia bacterial species (Clostridium coskatii ATCC No. PTA-10522, “PS02”) is provided. Under anaerobic conditions C. coskatii can convert CO and/or H₂ and/or CO₂ to ethanol or acetate. Thus, this novel bacterium is capable of transforming waste gases (e.g. syngas and refinery wastes) into useful products.

Species of human-derived bacteria belonging to the Clostridia class have been shown to induce accumulation of regulatory T cells (Treg cells) in the colon and suppress immune functions. Pharmaceutical compositions containing these bacteria can be used to prevent and treat immune-mediated diseases such as autoimmune diseases.

Oligosaccharides produced by an alternansucrase enzyme catalyzed reaction of sucrose with an acceptor oligosaccharide are effective as prebiotics for controlling enteric bacterial pathogens. Populations of enteropathogenic bacteria may be substantially reduced or inhibited by treatment of an animal with a composition comprising one or more of these oligosaccharides in an amount effective to promote the growth of beneficial bacteria. The method is particularly effective for the control of Salmonella species, enteropathogenic Escherichia coli, and Clostridia perfringens.

The invention provides a composite bacillus preparation containing three strains, a preparation method of the composite bacillus preparation and application of the composite bacillus preparation to ecological breeding, and belongs to the technical field of microorganism and feed additives. Bacillus coagulans, butyric acid clostridia and bacillus megaterium are used as fermentative strains respectively, and large-scale, low-cost and high-density fermentation production of spores is conducted through step-by-step magnification; three live bacterium preparations are prepared by mixing bacterial sludge with the spores and dry starch; the three live bacterium preparations are matched according to the equal weight ratio, the composite bacillus preparation is obtained, and the concentration of the spores reaches more than 1*108-109 cfu/g; the composite bacillus preparation serves as a microorganism and feed additive to be added to farmed animal feed according to the mass ratio ranging from 0.02% to 0.5%. The composite bacillus preparation is simple and stable in process, low in cost, high in spore content and environment tolerance, easy to store and high in survival rate; the purposes of composition and synergism are achieved through the collaborative supplementary effects of different bacilli in the aspect of micro-ecology adjustment, growth of farmed animals is promoted, the feed utilization rate and feed rewards are increased, diarrhea is prevented and reduced, and the breeding ecological environment is improved.

Methods of using clostridial toxins and other biological agents to thin skin and control fine wrinkles in humans are provided. In preferred embodiments the methods provide beneficial effects in humans.

The present invention relates to a combination of an anti-toxin, The present invention relates to a combination of an anti-toxin, an immunomodulator and a component that provides energy to mucosal cells, which may be useful for decreasing effects of Clostridia sp. or coccidia sp based diseases or other enteric diseases or by generally improving gastro intestinal health or function

The invention relates to a method for quickly culturing anaerobic hydrogen-producing granular sludge. The invention is characterized in that excess activated sludge which is cultured and pretreated by 60-100mg/L of cationic polyacrylamide is added to a reactor to ensure that the initial sludge concentration in the reactor is 12-25g/L; by using sugar-containing waste water as the substrate, the biochemical oxygen demand (COD) of intake water is 4000mg/L, the pH value is 7.5-8.5, the total hydraulic retention time in the reactor is gradually reduced from the original 15 hours to 3.5 hours, and the organic volume load is gradually increased from 6-10kgCOD/m<3> to more than 30kgCOD/m<3> in the moderate temperature (34-35 DEG C)condition; and the anaerobic hydrogen-producing granular sludge in which clostridia act as the main part accompanied with small amount of filamentous bacteria and sphaerophorus and the total volume of which accounts for 25-40% of the total volume of the reactor can be formed within 7-15 days. The reactor filled with the granular sludge can continuously produce fermentation gas the hydrogen content of which is 44-56%, the gas yield of the reactor is 10-16m<3>, and the hydrogen-producing efficiency can reach 3.1molH2/mol sucrose.

A method is disclosed for blocking or reducing physiological reaction in a mammal to the interaction of IgE antibodies present in said mammal upon contact with the corresponding antigen, by the administration to said mammal of a therapeutically effective amount of a neurotoxin (CnT) derived from Clostridia sp.

The invention discloses a method for increasing the butanol-acetone ratio and the butanol yield of clostridia ABE fermentation, and belongs to the technical field of biology. According to the method, corn flour is taken as a fermentation raw material, and a clostridium-saccharomyces cerevisiae mixed culture system is formed by appropriately adding an active saccharomyces cerevisiae and a butyric acid solution at the solvent production stage of the clostridia. The saccharomyces cerevisiae is capable of secreting various amino acids under a strict anaerobic condition and in a severe saccharomyces cerevisiae growth environment, wherein aromatic amino acids and aspartic amino acids all advantageous for butanol synthesis are greatly accumulated. On the basis, the small amount of added butyric acid is further capable of weakening the metabolism intensity of the closed loop of butyric acid. Under the dual combined action, the butanol-acetone ratio and the final butanol concentration of the ABE fermentation can be greatly improved under the premise of unchanged or slightly improved total solvent production intensity. The two indexes, namely butanol-acetone ratio and butanol concentration of the method are at the highest level in the related study reports of the batch fermentation production of butanol by use of wild clostridia and have important guiding significance for the ABE fermentation.

The subject invention provides compositions for alleviating type 1 diabetes (T1D). In preferred embodiments, the compositions comprise an effective amount of one or more antigen presenting cells (APCs) that have been pulsed with one or more bacterial isolates and/or compounds from the isolates. The bacteria used to pulse the APCs are, preferably, those that confer upon the APCs the ability to inhibit the generation of diabetes-promoting T cells. In specific embodiments, these bacteria may be, for example, Eubacteria or Clostridia. In a preferred embodiment, the APCs are dendritic cells (DCs).

The present invention relates to the use of type 2 cytokines and mucins for increasing the amount or activity of bacterial species of the Clostridia class in the gastrointestinal tract, for treating dysbiosis in the gastrointestinal tract, for treating gastrointestinal and inflammatory disorders, and for promoting wound healing in the gastrointestinal tract.

The invention aims at providing a method for improving fermentation efficiency of anaerobic qi-eating microorganisms. The method for improving the fermentation efficiency of the anaerobic qi-eating microorganisms comprises the following steps: firstly carrying out filtration interception on an anaerobic qi-eating microorganism bacterial liquid in a fermentation system by virtue of a hollow cellulose membrane, then carrying out back flushing by virtue of a culture medium, and carrying out fermentation on intercepted thalli again. The method for improving the fermentation efficiency of the anaerobic qi-eating microorganisms has the advantages that interconnection between a fermentation tank and a hollow cellulose membrane component is realized in a gaseous fermentation process of the anaerobic qi-eating microorganisms, so that fermentation liquor circulates between the inner cavity of the hollow cellulose membrane and the fermentation tank; meanwhile, a peristaltic pump connected with the outer wall of the hollow cellulose membrane component is used for pumping and drainage, realizing suction filtration on the fermentation liquor and intercepting the thalli, then a fresh culture medium is used for washing the thalli adhered in the cavity of the hollow cellulose membrane into the fermentation tank, and repeated and continuous fermentation is carried out; and the method for improving the fermentation efficiency of the anaerobic qi-eating microorganisms can be used for improving biomass accumulation of anaerobic qi-eating clostridia in the gaseous fermentation process and effectively improving yield of ethyl alcohol, butyl alcohol and hexyl alcohol which are produced by utilizing synthesis gas.

The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiple-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

The invention provides a primer compound for identifying intestinal microecological state and an application thereof. The primer compound is a specific primer designed for intestinal bacterium 16S rRNA; the specific primer includes random basic groups; the quantity of random basic groups is 3-5; the intestinal bacterium includes any one of or combination of at least two of symbiotic clostridia, bifidobacterium adolescentis, fusobacterium nucleatum, peptostreptococcus anaerobius or klebsiella. A kit researched and developed on the basis of the primer compound provided by the invention has a specificity for detecting intestinal microecological imbalance reaching up to 92.5% and a sensitivity reaching up to 80.43%.