57 results about "Clostridia" patented technology

A novel clostridia bacterial species (Clostridium coskatii ATCC No. PTA-10522, “PS02”) is provided. Under anaerobic conditions C. coskatii can convert CO and / or H2 and / or CO2 to ethanol or acetate. Thus, this novel bacterium is capable of transforming waste gases (e.g. syngas and refinery wastes) into useful products.

Species of human-derived bacteria belonging to the Clostridia class have been shown to induce accumulation of regulatory T cells (Treg cells) in the colon and suppress immune functions. Pharmaceutical compositions containing these bacteria can be used to prevent and treat immune-mediated diseases such as autoimmune diseases.

Oligosaccharides produced by an alternansucrase enzyme catalyzed reaction of sucrose with an acceptor oligosaccharide are effective as prebiotics for controlling enteric bacterial pathogens. Populations of enteropathogenic bacteria may be substantially reduced or inhibited by treatment of an animal with a composition comprising one or more of these oligosaccharides in an amount effective to promote the growth of beneficial bacteria. The method is particularly effective for the control of Salmonella species, enteropathogenic Escherichia coli, and Clostridia perfringens.

The invention provides a composite bacillus preparation containing three strains, a preparation method of the composite bacillus preparation and application of the composite bacillus preparation to ecological breeding, and belongs to the technical field of microorganism and feed additives. Bacillus coagulans, butyric acid clostridia and bacillus megaterium are used as fermentative strains respectively, and large-scale, low-cost and high-density fermentation production of spores is conducted through step-by-step magnification; three live bacterium preparations are prepared by mixing bacterial sludge with the spores and dry starch; the three live bacterium preparations are matched according to the equal weight ratio, the composite bacillus preparation is obtained, and the concentration of the spores reaches more than 1*108-109 cfu / g; the composite bacillus preparation serves as a microorganism and feed additive to be added to farmed animal feed according to the mass ratio ranging from 0.02% to 0.5%. The composite bacillus preparation is simple and stable in process, low in cost, high in spore content and environment tolerance, easy to store and high in survival rate; the purposes of composition and synergism are achieved through the collaborative supplementary effects of different bacilli in the aspect of micro-ecology adjustment, growth of farmed animals is promoted, the feed utilization rate and feed rewards are increased, diarrhea is prevented and reduced, and the breeding ecological environment is improved.

Methods of using clostridial toxins and other biological agents to thin skin and control fine wrinkles in humans are provided. In preferred embodiments the methods provide beneficial effects in humans.

The present invention relates to a combination of an anti-toxin, The present invention relates to a combination of an anti-toxin, an immunomodulator and a component that provides energy to mucosal cells, which may be useful for decreasing effects of Clostridia sp. or coccidia sp based diseases or other enteric diseases or by generally improving gastro intestinal health or function

A method is disclosed for blocking or reducing physiological reaction in a mammal to the interaction of IgE antibodies present in said mammal upon contact with the corresponding antigen, by the administration to said mammal of a therapeutically effective amount of a neurotoxin (CnT) derived from Clostridia sp.

The invention discloses a method for increasing the butanol-acetone ratio and the butanol yield of clostridia ABE fermentation, and belongs to the technical field of biology. According to the method, corn flour is taken as a fermentation raw material, and a clostridium-saccharomyces cerevisiae mixed culture system is formed by appropriately adding an active saccharomyces cerevisiae and a butyric acid solution at the solvent production stage of the clostridia. The saccharomyces cerevisiae is capable of secreting various amino acids under a strict anaerobic condition and in a severe saccharomyces cerevisiae growth environment, wherein aromatic amino acids and aspartic amino acids all advantageous for butanol synthesis are greatly accumulated. On the basis, the small amount of added butyric acid is further capable of weakening the metabolism intensity of the closed loop of butyric acid. Under the dual combined action, the butanol-acetone ratio and the final butanol concentration of the ABE fermentation can be greatly improved under the premise of unchanged or slightly improved total solvent production intensity. The two indexes, namely butanol-acetone ratio and butanol concentration of the method are at the highest level in the related study reports of the batch fermentation production of butanol by use of wild clostridia and have important guiding significance for the ABE fermentation.

The subject invention provides compositions for alleviating type 1 diabetes (T1D). In preferred embodiments, the compositions comprise an effective amount of one or more antigen presenting cells (APCs) that have been pulsed with one or more bacterial isolates and / or compounds from the isolates. The bacteria used to pulse the APCs are, preferably, those that confer upon the APCs the ability to inhibit the generation of diabetes-promoting T cells. In specific embodiments, these bacteria may be, for example, Eubacteria or Clostridia. In a preferred embodiment, the APCs are dendritic cells (DCs).

The present invention relates to the use of type 2 cytokines and mucins for increasing the amount or activity of bacterial species of the Clostridia class in the gastrointestinal tract, for treating dysbiosis in the gastrointestinal tract, for treating gastrointestinal and inflammatory disorders, and for promoting wound healing in the gastrointestinal tract.

The invention aims at providing a method for improving fermentation efficiency of anaerobic qi-eating microorganisms. The method for improving the fermentation efficiency of the anaerobic qi-eating microorganisms comprises the following steps: firstly carrying out filtration interception on an anaerobic qi-eating microorganism bacterial liquid in a fermentation system by virtue of a hollow cellulose membrane, then carrying out back flushing by virtue of a culture medium, and carrying out fermentation on intercepted thalli again. The method for improving the fermentation efficiency of the anaerobic qi-eating microorganisms has the advantages that interconnection between a fermentation tank and a hollow cellulose membrane component is realized in a gaseous fermentation process of the anaerobic qi-eating microorganisms, so that fermentation liquor circulates between the inner cavity of the hollow cellulose membrane and the fermentation tank; meanwhile, a peristaltic pump connected with the outer wall of the hollow cellulose membrane component is used for pumping and drainage, realizing suction filtration on the fermentation liquor and intercepting the thalli, then a fresh culture medium is used for washing the thalli adhered in the cavity of the hollow cellulose membrane into the fermentation tank, and repeated and continuous fermentation is carried out; and the method for improving the fermentation efficiency of the anaerobic qi-eating microorganisms can be used for improving biomass accumulation of anaerobic qi-eating clostridia in the gaseous fermentation process and effectively improving yield of ethyl alcohol, butyl alcohol and hexyl alcohol which are produced by utilizing synthesis gas.

The invention provides a microecological feed additive capable of improving the eggshell quality and an application method thereof. The microecological feed additive comprises the following components: bacillus subtilis, bacillus natto, clostridia butyricum, lactobacillus metabolites, lactobacillus activators and carriers. By adopting the microecological feed additive, the microecological flora balance of laying poultry can be adjusted, the oviduct inflammation of the laying poultry can be reduced, and the calcium-phosphorus ratio in the blood of the laying poultry can be adjusted. Compared with similar additives, the microecological feed additive has the advantages of high effectiveness, good specificity, no residues and no side effects. When the microecological feed additive is used, the eggshell quality can be improved.

The invention discloses a novel efficient synbiotics intestines-targeting microspheric capsule and a preparation method of the novel efficient synbiotics intestines-targeting microspheric capsule. The novel efficient synbiotics intestines-targeting microspheric capsule comprises 30-40% of probiotics and 60-70% of prebiotics, wherein the probiotics is a mixture composed of 40 to 50% of clostridia butyricum and 50 to 60% of lactobacillus sporogenes; and the prebiotics is the mixture composed of 60 to 70% of cerevisiae zymosan and 30 to 40% of sulphated cerevisiae zymosan. The novel micro-capsule synbiotics additive for the feed, prepared by the method disclosed by the invention, plays the effects of both the probiotics and the prebiotics, has remarkable effects of improving the utilization rate of the feed, promoting the growth of animal and improving the resistance and immunity of the human body; and the novel efficient synbiotics intestines-targeting microspheric capsule is sable in quality, safe, and free from toxic and side effect, brings no residues and pollution, and is beneficial for the human health and environmental protection.

The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiple-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

The invention discloses a microbial fermentation and detoxification method of rapeseed cake. The method comprises the following steps: adding a crushed detoxification synergist to the rapeseed cake; inoculating a bacillus subtilis, a clostridia butyricum, a lactobacillus acidophilus and a saccharomyces cerevisiae solid strain to the mixture and mixing evenly; fermenting, drying the mixture to obtain a detoxified rapeseed cake product. According to the invention, the content of glucoside sulphate in the detoxified rapeseed cake product does not exceed a safety level specified by the feed, the nutritional value is higher than that of the unfermented and undetoxified rapeseed cake, the protein content reaches 42 to 45%, and the content of disassociated amino acid reaches more than 10%, so that the detoxified rapeseed cake product can be directly used as protein feed for livestocks and aquatic products. The method provided by the invention can better solve the problems of incomplete detoxification, difficult elimination of anti-nutritional factors, nutrition loss and complexity in preparation process in prior art. The method has the advantages of good detoxification effect, simplicityin preparation and low energy consumption, and can reach the standard feed requirement of producing the non-toxic rapeseed cake. Therefore, the problem of shortage of feed protein resources in China is solved.