1139 results about "Gastrointestinal tract" patented technology

The invention belongs to the technical field of medical image processing, and particularly discloses a CT image segmentation and classification system based on class activation graph guidance, and the specific technical scheme is that the system constructs three functional complementary segmentation and classification networks of a coarse segmentation network, a classification network and a fine segmentation network; according to the method, collaborative optimization and performance improvement of classification and segmentation tasks are realized, a closed-loop optimization process is formed by a multi-task collaborative mechanism, and a bidirectional optimization path of segmentation guide classification and classification feedback segmentation is constructed by utilizing internal correlation existing in the segmentation and classification tasks; a coarse segmentation result containing tumor position information is used for enhancing the tumor discrimination capability of a classification network, a class activation graph generated by the classification network is converted into a spatial position weight, the segmentation network is guided to pay attention to a focus area with discrimination, a finer segmentation mask is generated, and through bidirectional information interaction, the tumor discrimination capability of the classification network is improved. The two dimensions of precise positioning and pathological discrimination of gastrointestinal tumors are remarkably improved.

To provide a device and a method for treating at least one of hypertension, pulmonary arteries, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pain, asthma or chronic obstructive pulmonary disease by delivering an effective amount of a formulation to a tissue.SOLUTION: In embodiments of the present invention, the formulation may include at least one of a gas, a vapor, a liquid, a solution, an emulsion or a suspension of one or more ingredients. In embodiments of the present invention, amounts of the formulation and / or energy are effective in injuring or damaging tissue, nerves and nerve endings in order to relieve disease symptoms.SELECTED DRAWING: Figure 3B

The invention provides a medical image segmentation method and system based on spatial detail enhanced vision, and relates to the technical field of image processing. The method comprises the following steps: performing initial feature mapping on an input and preprocessed medical image to obtain an embedded feature map; the embedded feature map is input into an encoder for feature extraction, and multi-scale features are obtained; the encoder comprises a plurality of encoding stages, and the number of channels is doubled and the spatial resolution is halved through down-sampling operation between the encoding stages; the multi-scale features are subjected to up-sampling and spatial enhancement reconstruction step by step through a decoder, and a high-precision segmentation result is generated; wherein the decoder comprises a plurality of decoding stages, the decoding stages correspond to the encoding stages, and feature fusion is carried out between the corresponding stages of the encoder and the decoder through jump connection. According to the method, the boundary description precision and the segmentation robustness of the low-contrast image can be improved without increasing the linear complexity, and the method is suitable for medical image segmentation scenes of skin lesions, gastrointestinal polyps and the like.

The invention relates to the technical field of artificial intelligence, and discloses a method and a system for dynamically predicting the risk of harm of feed mycotoxin to livestock and poultry. The method comprises the following steps: constructing a metabolic digital twin model based on a multi-organ coupling dynamics mechanism, connecting a gastrointestinal tract, a liver and a kidney through blood flow parameters to form a closed loop topology network, establishing a toxin migration rate equation, and verifying bioavailability; collecting feed toxin concentration and livestock and poultry physiological data in real time; after distributing the initial toxin load, iteratively generating target organ dynamic concentration distribution by adopting a Runge-Kutta method; an organ exposure index is calculated based on an organ specific hazard threshold, key organs are positioned, and low / high risk levels and toxin accumulation paths are output. The method solves the problems that a traditional static model is low in efficiency and poor in organ difference adaptability when being used for dynamically predicting the risk of harm to livestock and poultry caused by feed mycotoxin.

The invention relates to the technical field of gastrointestinal tracts, in particular to a gastrointestinal tract ultrasonic virtual simulation nursing teaching platform which comprises a function module and a hardware configuration module. The function module comprises an anatomy learning module, an ultrasonic simulation module, a case training module and an examination and evaluation module; the hardware configuration comprises a VR head-mounted display, an ultrasonic simulator and an operation panel. The system has the advantages of safe and risk-free training, standardized process learning, immersive scene experience and instant feedback evaluation, a high-fidelity gastrointestinal tract ultrasonic virtual simulation teaching platform for critically ill patients is constructed, a 3D virtual model is constructed by using a virtual simulation technology, knowledge is presented dynamically and visually, real situations such as ICU wards and the like are simulated through VR, and real-time feedback evaluation of the gastrointestinal tracts of the critically ill patients is realized. The learning initiative and the sense of participation are stimulated; an ICU environment is virtualized, an unlimited'trial-and-error 'practice space is provided, the equipment cost is reduced, potential safety hazards are avoided, and space-time and safety barriers are broken.

The invention belongs to the technical field of preparation of probiotic products, and relates to a lactic acid bacteria microcapsule as well as a preparation method and application thereof. The method comprises the following steps: uniformly mixing sodium alginate, modified montmorillonite and sterile water, cooling, adding a prepared lactic acid bacteria seed solution, and fully and uniformly mixing to form an emulsion; spraying the emulsion into a calcium chloride solution by adopting an extrusion method, stirring and curing to obtain microcapsules; and culturing the prepared microcapsule in a lactic acid bacteria liquid culture medium to obtain the lactic acid bacteria microcapsule after the culture is finished. The lactobacillus is effectively protected by adopting an extrusion-method single coating and post-coating culture process, so that the stability of the lactobacillus to a humid and hot environment and the gastrointestinal stress resistance are improved, and meanwhile, the release performance of the lactobacillus in the gastrointestinal tract is ensured. The problem that an existing microcapsule coating technology cannot achieve balance between improvement of the hygrothermal stability and gastrointestinal stress resistance of the probiotics and guarantee of good release performance of the probiotics in the gastrointestinal tract is solved.

The invention provides a gastrointestinal tract disease postoperative rehabilitation method and system based on big data, and relates to the technical field of gastrointestinal tract postoperative rehabilitation, historical rehabilitation patient data is acquired and clustered, historical rehabilitation patient clustering results and disease cluster similarities corresponding to different types of gastrointestinal tract disease clusters in the clustering results are acquired, and the disease cluster similarities are obtained; generating a gastrointestinal tract disease candidate set based on the disease cluster similarity, fusing a preset gastrointestinal tract disease standard vector with the gastrointestinal tract disease candidate set based on a gastrointestinal tract constraint fusion mechanism to generate a gastrointestinal tract disease rehabilitation prediction curve, and constructing a recombinant gastrointestinal tract disease candidate set; performing threshold calculation based on the recombinant gastrointestinal disease candidate set to obtain a dynamic threshold, obtaining a real-time data vector of a to-be-rehabilitated patient, matching a corresponding gastrointestinal disease rehabilitation prediction curve, comparing the real-time data vector of the to-be-rehabilitated patient with the gastrointestinal disease rehabilitation prediction curve, and implementing a corresponding strategy based on a comparison result. The method can assist a physician in generating a treatment scheme.

The invention provides cubilose peptide and a key preparation method of cubilose peptide maternity cubilose, and the preparation method of the cubilose peptide comprises the following steps: soaking dry cubilose in pure water at 0-4 DEG C according to a material-liquid ratio of 1: 10 for 2 hours, scattering, and spin-drying to obtain soaked cubilose; mixing the soaked cubilose with pure water according to a mass ratio of 1: (15-20), sealing, stewing at 121-123 DEG C for 12-15 minutes, cooling to room temperature, and repeatedly stewing once to obtain fresh stewed cubilose; carrying out an in-vitro digestion experiment on the freshly stewed cubilose, and simulating the digestion process of the freshly stewed cubilose in gastrointestinal tracts to obtain digested cubilose; and centrifuging the digested cubilose to obtain a supernatant, treating the supernatant, carrying out protein sequencing, and carrying out on-line database comparison to screen out peptide fragments with high matching degree and response value greater than 109, thereby obtaining the cubilose peptide. The cubilose peptide can significantly improve the proliferation rate of nerve cells, and provides a cell basis for the development of a nervous system.

The invention belongs to the technical field of feed additives, and particularly relates to slow-release fat powder for pigs and a preparation method of the slow-release fat powder. The slow-release fat powder for pigs comprises an intragastric adhesion-slow release layer, a small intestine forepart bile acid response controlled release layer and a small intestine posterior microbe response controlled release layer. The prepared slow-release fat powder for the pigs is good in stability, accurate release of different nutritional ingredients in different parts of gastrointestinal tracts of the pigs can be achieved, and powerful support is provided for sustainable development of the pig raising industry.

A spore of a bacillus subtilis B.subtilis WB600 strain is used as an antigen delivery carrier, spore coat protein C (CotC) is used as anchoring protein, a key protein ATPase gene and a CotC gene of micropterus salmoides iridovirus are fused through a gene fusion technology, a recombinant spore surface display system is constructed, the ATPase antigen is stably displayed on the spore surface, and an oral vaccine is prepared. After being orally applied to fishes, the vaccine can tolerate the gastrointestinal tract environment and is accurately delivered to intestinal related lymphatic tissues to stimulate fish immunity, and finally prevention and control of the iridovirus of the micropterus salmoides are achieved.

The invention discloses an enteral nutritional complication risk grading early warning management method and a related device. The method comprises the following steps: generating a multi-modal data vector according to clinical data, environmental data and behavior data of a patient; inputting the multi-modal data vector and the individual feature information of the patient into a trained dynamic risk prediction model, and outputting occurrence probabilities of gastrointestinal complications, mechanical complications, infectious complications and metabolic complications; wherein the individual feature information comprises age, basic diseases and nutrition states; generating a personalized intervention scheme of the patient according to a risk grading result for reference of medical staff; and inputting the intervention effect of the medical personnel, the real-time data feedback of the patient and the enteral nutritional complication risk early warning system into the dynamic risk prediction model so as to adjust model parameters of the dynamic risk prediction model. Through the dynamic risk prediction model and the personalized intervention scheme, the prediction precision of the enteral nutritional complication risk is improved.

The invention discloses a triggering probiotic-drug conjugate and a preparation method and application thereof, and belongs to the technical field of oral drug delivery systems, the triggering probiotic-drug conjugate comprises probiotics, an adhesive inner layer formed by coordination of tannic acid and Fe < 3 + >, and an outer layer formed by pterostilbene-phospholipid bridged by ROS-responsive thioether bonds and cholesterol; the inner layer coats the surfaces of the probiotics through coordination, and the outer layer coats the outer part of the inner layer through self-assembly. An outer lipid layer is decomposed under high-concentration ROS in an inflammation colon area, and probiotics coated with pterostilbene and a tannic acid layer are released. Pterostilbene relieves inflammation and rebuilds a pathological microenvironment, and catechol groups in a tannic acid layer and the surface of the intestinal tract generate multiple interactions to promote planting of probiotics. In UC mouse models, the conjugates exhibit enhanced therapeutic effects by inhibiting inflammation, restoring intestinal barrier function, and improving intestinal microbiota homeostasis. The invention has important transformation potential in clinical application of gastrointestinal diseases.

The invention relates to a plant lactobacillus with effects of dispelling effects of alcohol, protecting the liver and restoring consciousness and application of the plant lactobacillus. The plant lactobacillus is a plant lactobacillus BGI-J9 strain, and the preservation number of the plant lactobacillus is CCTCC NO: M 20242630. The invention further discloses a preparation method of the plant lactobacillus with the effects of dispelling effects of alcohol, protecting the liver and restoring consciousness and application of the plant lactobacillus with the effects of dispelling effects of alcohol, protecting the liver and restoring consciousness. The strain has excellent tolerance to gastric acid, intestinal juice and cholate in a gastrointestinal tract system, can survive in the gastrointestinal tract, and provides a basis for continuously playing a probiotic effect; the compound has excellent inhibition capability on common intestinal pathogens; free radicals can be removed, and oxidative damage to the body is reduced; good alcohol metabolism enzyme synthesis capability and alcohol metabolism promoting potential are realized; the strain also has an excellent improvement effect on alcohol-damaged mice, specifically, the metabolism of ethanol and acetaldehyde in a body is accelerated, the occurrence time of drunkenness is obviously delayed, and the sobering time is shortened; intestinal injury and systemic inflammation caused by alcohol are improved; liver oxidative stress caused by alcohol is improved, and the occurrence and development process of alcoholic fatty liver is delayed; and cognitive function impairment caused by alcohol is improved.

The invention provides infant rapid brewing rice flour based on enzymolysis and superfine water grinding and a preparation method thereof, and belongs to the technical field of food processing. Rice is subjected to raw material differential temperature pretreatment and multi-stage hydration pulping, and a stable three-dimensional microscopic network structure with starch particles as filler and soluble protein and colloid as a continuous phase is constructed; then, food-grade lactic acid bacteria pre-fermentation is combined with sequential action of various enzymes, and starch and protein are subjected to mild directional hydrolysis under the condition of simulating dynamic pH of gastrointestinal tract digestion, so that the nutritional and digestible infant healthy rice flour is prepared, and the problems that the rice flour is easy to agglomerate, non-uniform in dispersion and low in nutritional value during brewing are solved. The digestion and absorption efficiency of macromolecular nutrient components such as starch and protein is relatively low, and the nutrition and flavor of the product mainly depend on exogenous addition, so that the naturalness and functionality are insufficient. The rice flour disclosed by the invention has excellent reconstituability and nutrient absorption rate, and is suitable for being used as a healthy nutritional complementary food for infants of 6-36 months.

The invention discloses a gastric retention capsule robot and a gastric retention capsule device, and relates to the technical field of medical instruments, the gastric retention capsule robot comprises a capsule shell, a robot body, an unfolding arm, a driving mechanism and a restoring mechanism; the robot body is arranged in the capsule shell, and a carrying module used for carrying the functional module is arranged on the robot body; the unfolding arm is movably arranged on the robot body; the driving mechanism is arranged on the robot body, and after the capsule shell is dissolved, the driving mechanism can drive the unfolding arm to unfold towards the outside of the robot body so as to limit discharging of the robot body; the restoring mechanism is arranged on the robot body and can fold the unfolding arm to be attached to the robot body so that the robot body can be discharged. The device can be detained in the stomach and can be discharged from the gastral cavity through active folding, the timeliness is good, the risks of gastrointestinal tract blockage, mechanical injury and the like existing in a passive discharging mode are avoided, and the personal safety of a patient is guaranteed.

The invention relates to the technical field of critical nutrition medical treatment, and discloses a critical patient enteral nutrition diarrhea risk prediction model system. A nutrition parameter acquisition module of the system is used for acquiring enteral nutrition formula parameters, including nutrient solution osmotic pressure, infusion speed and nutrient solution temperature, of a critical patient; the physiological index analysis module is used for collecting intestinal flora abundance data, serum albumin level and gastrointestinal peristalsis frequency of the critical patient; the risk feature extraction module is used for calculating an intestinal tolerance feature value according to the enteral nutrition formula parameters and the intestinal flora abundance data; and the prediction model construction module is used for constructing a diarrhea risk prediction model based on the intestinal tolerance characteristic value and the serum albumin level. According to the system, comprehensive acquisition and analysis of enteral nutrition related data of critical patients can be realized, objectivity and accuracy of diarrhea risk prediction are improved, and support is provided for clinical enteral nutrition scheme adjustment and diarrhea prevention.

The invention discloses a siphon type gastrointestinal nursing pressure reducer with a pressure regulating function. Comprising a support, a sealing box is installed at the top of the support, a drainage tube is connected to one side of the sealing box, a pressure adjusting structure is installed at the end of the drainage tube, the pressure adjusting structure is connected with a trigger structure, the trigger structure is located in the sealing box, and a conveying tube is connected to the other side of the sealing box. Through the arrangement of the drainage tube, the pressure regulating structure and the triggering structure, the device can be driven without additional electrical equipment; liquid in the gastrointestinal tract is efficiently led out through the siphon effect, so that the energy-saving and environment-friendly effects are achieved, in the using process, after the liquid in the gastrointestinal tract is completely led out, the pressure in the system can be naturally reduced, at the moment, the pressure adjusting structure cannot be triggered, and then the triggering structure is driven to stop the siphon effect.

The present application belongs to the technical field of medical care, and particularly relates to a nutrient solution delivery device for assisting in nursing of esophageal cancer patients, which comprises a mounting seat, the inside of the mounting seat is provided with a fixing part, the fixing part can extrude and fix the nutrient bag placed inside to avoid the nutrient bag from deviating during the operation of the equipment; the inside of the fixing part is provided with a driving part, the driving part moves back and forth inside the mounting seat, the driving part can extrude the nutrient solution inside the nutrient bag to flow during the back and forth movement; the inside of the driving part is further provided with a stirring part which rotates, the stirring part can rotate by using the power of the back and forth movement of the driving part, and the rotation of the stirring part further promotes the flow of the nutrient solution inside the nutrient bag; the inside of the mounting seat is provided with a delivery part. The present application uniformly heats the nutrient solution and delivers it into the gastrointestinal tract of the patient, the warm nutrient solution can promote blood circulation and increase the peristalsis of the intestinal tract, which is helpful to improve the digestion and absorption rate of the nutrient components.

The invention belongs to the technical field of materials, discloses a preparation method and application of novel stomach and intestinal tract passing sustained-release tannic acid, and particularly discloses a stomach and intestinal tract passing enteric coating material which comprises a surfactant, sugar alcohol, hydrogenated grease, polyacrylic resin and a thickening agent. The stomach-passing enteric coating material does not use expensive commercially available enteric coating materials, but adopts common surfactants, sugar alcohol substances and other substances, so that the grease and the water can be better fused, and the grease can be better coated outside in the coating process. The stomach-passing enteric coating material can ensure that tannic acid is not damaged by gastric acid, reduces the influence on animal digestive enzymes, and can be slowly released in intestinal tracts to be absorbed and utilized.

The process comprises providing a recombinant vaccine construct, wherein said construct comprises genetically modified Lactobacillus plantarum NC8 as a live vector; modifying the genetic structure of said Lactobacillus plantarum NC8 to express conserved Salmonella antigens, including PagN, SopE2, and FliC, anchored by a ptrk 892 backbone with a constitutive promoter, phosphoglycerate mutase (PGM); incorporating Signal Lp_2145 and cAM12 Anchor sequences into said genetic construct to enhance surface expression of recombinant proteins on Lactobacillus plantarum NC8; administering said recombinant vaccine orally to poultry, leveraging the probiotic properties of Lactobacillus plantarum NC8 for effective colonization of the poultry gastrointestinal tract; inducing a prolonged and intensified immune response by ensuring sustained high-level expression of target antigens through the utilization of the robust constitutive promoter, phosphoglycerate mutase (PGM); and optimizing immunogenicity through the surface expression of recombinant proteins on Lactobacillus plantarum NC8, fostering a robust and precisely targeted immune response.

The invention discloses a single-cell probiotic packaging method of thiolated guluronic acid oligosaccharide and a probiotic microcapsule, and relates to the technical field of biological medicines. The packaging method comprises the following steps: mixing a thiolated guluronic acid oligosaccharide solution with a probiotic suspension to form a probiotic-polysaccharide mixed solution; and adding a calcium chloride solution into the probiotic-polysaccharide mixed solution, and stirring to form the single-cell microcapsule encapsulating the probiotics. The packaging method can protect a single strain from being damaged by an external adverse environment to the maximum extent, and the survival rate is increased. Meanwhile, the obtained single-cell microcapsule can improve the digestion of the probiotics, the survival rate of the probiotics under the oxidative stress environment and the antibiotic combination, has high stability, and prolongs the intestinal residence time of the probiotics. An innovative solution is provided for the problems that in the existing medicine field, probiotic preparations cannot improve the gastrointestinal stress resistance of probiotics, and antibiotics lose efficacy when combined.

The invention belongs to the technical field of probiotic protection, and discloses a preparation method and application of probiotic-loaded sulfydryl hyaluronic acid-based hydrogel, sulfydryl hyaluronic acid is prepared by taking cysteamine hydrochloride as a substrate, and connection of L-glutamine is further catalyzed through a cross-linking agent, so that the sulfydryl hyaluronic acid-based hydrogel is obtained. The cross-linking agent is a mixture of N-hydroxysuccinimide and 1-ethyl-(3-dimethylaminopropyl) carbodiimide or a mixture of N-hydroxysuccinimide and 1-hydroxybenzotriazole (HOBT), and the cross-linking agent is a mixture of N-hydroxysuccinimide and 1-ethyl-(3-dimethylaminopropyl) carbodiimide and 1-hydroxybenzotriazole (HOBT). The hydrogel prepared by the preparation method disclosed by the invention is used as a probiotic carrier, so that the influence of complex gastrointestinal tracts is effectively resisted, the hydrogel accurately reaches an intestinal injury part and is split, and the targeted intestinal controllable release of probiotics is realized; meanwhile, the L-glutamine is introduced and has a synergistic effect with the probiotics to relieve specific intestinal diseases, so that the L-glutamine can be used as a probiotic supplement for the specific intestinal diseases.

The invention belongs to the field of microorganisms, and particularly relates to lactococcus lactis Jlus 880314 and application thereof. The strain is classified and named as Lactococcus lactis, and is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation address is No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing; the preservation number of the strain is CGMCC No. 33961. Time-of-flight mass spectrometry analysis shows that nisin exists in a metabolite of the strain, and the strain can be used for producing nisin. The compound shows an excellent and wide antibacterial function in antibacterial experiments, can be used for preparing antibacterial drugs, particularly has a remarkable inhibiting effect on growth of gram-negative bacteria and fungi, can be used for preparing drugs for relieving or treating enteritis, or preparing drugs, nourishment or health care products for regulating gastrointestinal tract micro-ecological balance of people or animals, and can be used for preparing medicines for relieving or treating enteritis. The compound can also be used for preparing antibacterial food additives and / or animal feed additives. A hemolysis experiment result shows that hemolysis is avoided, toxic and side effects are small, and wide development prospects and application values are achieved.

The invention discloses a gastrointestinal decompression nursing device and a gastrointestinal tract pressure supervision system, and belongs to the technical field of medical nursing. A gastrointestinal decompression nursing device comprises a suction tank, a regulation and control box, a stomach tube and a flexible arm band, and the regulation and control box comprises a data preprocessing module and a control module; a plurality of flexible resistance type sensors are distributed in the flexible arm band at equal intervals, an in-vivo capsule is arranged at the front end of the stomach tube, and a pressure sensor and a three-axis accelerometer are arranged in the in-vivo capsule. According to the gastrointestinal nursing pressure reducer, the problem that an existing gastrointestinal nursing pressure reducer cannot achieve pressure nursing and supervision work according to different patients is solved, the in-vivo capsule is integrated with the pressure sensor, the triaxial accelerometer and the impedance sensor, and the pressure in an intestinal tract cavity, the peristalsis frequency and the content impedance can be synchronously collected; in combination with body surface pressure gradient data of the flexible arm band, improper treatment caused by misjudgment is avoided, and serious complications such as intestinal perforation and bleeding caused by delayed treatment are avoided.

The invention discloses lactobacillus plantarum OBM7 and application thereof, and belongs to the technical field of biology. The strain is preserved in the Guangdong Microbial Culture Collection Center (GDMCC) on November 12, 2025, the preservation address is the 5th floor of the building 59, No.100 Courtyard, Xianlie Middle Road, Guangzhou, and the preservation number is GDMCC NO. 67282; and the probiotic preparation does not contain antibiotics or drug residues, and meets the development requirements of green and healthy breeding. The probiotic preparation can specifically prevent and control lamb diarrhea, significantly reduce the fatality rate of lamb diarrhea, effectively improve the survival rate of lambs, and provide targeted protection for lamb intestinal health; the lamb feed can regulate lamb gastrointestinal tract micro-ecological balance, improve digestion and absorption functions, significantly improve feed intake and feed conversion efficiency, and promote lamb growth performance improvement. Reliable technical support is provided for efficient, green and healthy breeding of lambs, high practicability and wide industrial application prospects are achieved, and the method has great significance in promoting green transformation of the livestock breeding industry.

The invention discloses a prebiotic-loaded intestinal targeting exosome and a preparation method and application thereof.The preparation method comprises the steps that firstly, plasmids containing intestinal cell targeting peptide sequences are constructed through a gene editing technology, the plasmids are transfected and introduced into cells, the transfected cells are screened with antibiotics, and cell strains stably expressing intestinal cell targeting peptides are obtained; then culturing and adding prebiotics, and continuously culturing to enable the cells to take in the prebiotics and release the exosomes loaded with the prebiotics; and finally, collecting cell culture supernate, and centrifuging and resuspending for multiple times under a low-temperature condition to obtain the prebiotics-loaded intestinal targeting exosome. According to the preparation method, extraction of the exosome, loading of the prebiotics and an intestinal targeting modification process are optimized, so that the prepared intestinal targeting exosome loaded with the prebiotics can be used for remarkably improving the loading efficiency and intestinal targeting of the prebiotics and enhancing the stability of the exosome in gastrointestinal tracts; therefore, the delivery efficiency and the treatment effect of the prebiotics in the intestinal tract are improved.

The invention relates to the technical field of prebiotics preparation, and discloses a preparation method of prebiotics applied to reproduced areca catechu, and the preparation method comprises the following steps: carrying out enzyme catalysis reaction on sucrose by adopting fructosyl transferase to prepare fructo-oligosaccharide; according to the method, beta-galactosidase is adopted to carry out enzyme catalysis reaction on lactose, so that galactooligosaccharide is prepared; respectively carrying out decoloration, ion exchange, nanofiltration concentration and spray drying on the candy oligosaccharide and the galactooligosaccharide to obtain powder; the method comprises the following steps: mixing fructo-oligosaccharide powder and galactooligosaccharide powder according to a ratio, and uniformly distributing the mixture in a reproduced areca-nut matrix by adopting a spray-drying blending or low-temperature vacuum mixing mode to form a functional reproduced areca-nut product; according to the invention, low-temperature drying is carried out on the product after blending or vacuum mixing, so that the prebiotic areca nuts are released along with saliva in the chewing process, and are selectively utilized by bifidobacteria and lactic acid bacteria after entering the stomach and intestine, thereby achieving the purposes of regulating intestinal flora and improving the health-care function.

A system for targeted delivery of a medicament to the gastrointestinal tract (e.g., selectively to the duodenum) of a subject. The system includes a medicament, a mucoadhesive layer at least partially surrounding the medicament, and an enteric coating encasing the medicament and mucoadhesive layer. The enteric coating comprises a material degradable by a pH of the GI tract and a material digestible by a lipase. Also provided are method of making and using the system for targeted delivery of a medicament to the gastrointestinal tract. Also provided are a system for deploying a medicament-containing needle system using an expanding element. The system includes a medicament-containing needle system and an expanding element within a capsule. The capsule is initially coated with an enteric coating. As the enteric coating degrades the expanding element absorbs fluid that enters the capsule and expands to deploy the medicament-containing needle system from the capsule.

The invention discloses an upatinib emulsifiable paste and a preparation method thereof, the emulsifiable paste is directly smeared on an affected part, administration and use are convenient, diseases are rapidly relieved, the number of treatment times is reduced, the influence of a gastrointestinal tract absorption way on a medicine is reduced, toxic and side effects of gastrointestinal tract administration are reduced, the upatinib emulsifiable paste fills the market blank, administration of a patient is facilitated, and the curative effect of the upatinib emulsifiable paste is improved. And the market prospect is wide.

The invention relates to the technical field of food processing, in particular to fish-derived protein gel special for 3D printing dysphagia and having a customized digestion characteristic and a lycopene release function as well as a preparation method and application of the fish-derived protein gel. The lycopene-loaded IN / KGM gel system is constructed by combining a food additive manufacturing technology and a dynamic old people digestion model, and the rheological property and swallowing safety of the gel are optimized by regulating and controlling the ratio of IN to KGM; the customized digestion characteristics of the gel and the adaptability of the gel to the digestion function of the old people are researched by utilizing an in-vitro dynamic digestion model of the old people; the loading and releasing behaviors of lycopene in a gel system are explored, the bioaccessibility of lycopene in the gastrointestinal digestion process of old people is evaluated, the interaction mechanism of IN and KGM in the gel forming and digestion process is disclosed, and a theoretical basis and technical support are provided for developing personalized nutritious food suitable for the old people with dysphagia.