16 results about "Gastric wall" patented technology

The application discloses a percutaneous gastric interventional fistula device, which comprises a drill, a fixing assembly and a fistula tube drill, the drill is hollow, the end of the drill is provided with a puncture part, the puncture part can drill a fistula hole on an abdominal wall and a gastric wall, the fixing assembly is arranged on the outer wall of the drill and can fix the drill on the fistula hole and seal the fistula hole, and the fistula tube is communicated with the drill, and nutrient liquid can sequentially pass through the fistula tube and the drill and enter a stomach. The percutaneous gastric interventional fistula device can conveniently perform fistulization and simultaneously reduce operation time.

The invention relates to the technical field of biological medicine, and discloses a natural product for targeted inhibition of a KCNQ1 / KCNE2 complex channel and application of the natural product for targeted inhibition of the KCNQ1 / KCNE2 complex channel in preparation of a medicine for treating or preventing gastric ulcer, and an application method of a pharmaceutical composition comprises the following steps: S1, applying the pharmaceutical composition to a medication object; s2, the natural product interacts with a KCNQ1 / KCNE2 complex channel on a gastric wall cell membrane, and potassium ion current of the complex channel is inhibited; s3, weakening functions of H < + > / K < + >-ATPase in gastric wall cells by inhibiting potassium ion current, so that gastric acid secretion is reduced, and gastric ulcer is treated or prevented. According to the invention, gastric acid is indirectly regulated and controlled through targeted inhibition of gastric wall cell KCNQ1 / KCNE2 complex channels, and a new strategy for treating gastric ulcer, which is milder and has safety potential, is provided.

The invention relates to a stomach adhesion type double-network hydrogel sensor capable of realizing long-time gastric acid imaging and application of the stomach adhesion type double-network hydrogel sensor. The RHO-PDI probe takes perylene bisimide as a framework and rhodamine B as an acid response unit, pKa is approximately equal to 1.97, and 500-650 nm fluorescence is emitted in gastric acid. The double-network hydrogel is formed by crosslinking sodium polyalginate-calcium ions and polyethylene glycol dithiol-four-arm maleimide, has excellent mechanical strength and gastric wall adhesiveness, and realizes long-term, stable and non-invasive dynamic monitoring of gastric acid and circadian rhythm hormone change tracking.

This invention relates to a gastric drug delivery system based on biomechanically responsive intelligent deformation and anchoring, and its preparation method. The system includes a main body, multiple microneedle structures, a drug-loading unit, and a controlled-release unit. The main body is made of a thermoresponsive shape memory polymer and includes a head and multiple tentacles. The head is spherical with an opening, and the tentacles are distributed around the opening. Multiple microneedle structures are disposed on the tentacles. The drug-loading unit contains a metal-organic framework carrier and a drug, with the drug loaded on the metal-organic framework carrier. The drug-loading unit is distributed in the main body and / or multiple microneedle structures. When a triggering factor occurs, the drug-loading unit releases the drug. The controlled-release unit is used to control the release rate of the drug in the drug-loading unit. The main body structure of this invention utilizes the shape-restoring force generated by thermo-induced mechanical deformation to achieve stable buoyancy and fluid obstruction in gastric juice. The microneedle structures anchor to the gastric wall, effectively counteracting mechanical displacement caused by gastric peristalsis, enabling precise on-demand drug delivery.

The invention discloses an expandable intragastric balloon and an implantable device, and relates to the technical field of medical instruments. The expandable intragastric balloon comprises an inner membrane layer, an outer membrane layer and a stretching belt. The cross section of the inner film layer is closed, the outer film layer is arranged outside the inner film layer in a surrounding mode and connected with the inner film layer, the outer film layer and the inner film layer jointly define an expansion cavity, the stretching belt is arranged in the expansion cavity and connected between the outer film layer and the inner film layer, and the inner film layer, the stretching belt and the outer film layer are all made of flexible materials. The outer membrane layer is used for expanding outwards and abutting against the stomach wall when the filling medium is introduced into the expanding cavity, and the inner membrane layer is pulled open through the stretching belt so that a chyme channel can be formed in the inner membrane layer. The expandable intragastric balloon provided by the invention can realize large-degree volume compression under the condition of ensuring the passability of a chyme channel, and the compression direction is not limited, so that the expandable intragastric balloon can be conveniently and quickly implanted into the stomach, and the safety is improved.

The application discloses a kind of adjustable esophageal cardiac particle stents and including its gastric tube, particle stent includes stent body, swimming ring-shaped air bag, the stent body is made of elastic medical material, overall is smooth cylinder, cylinder cavity surrounded by cylinder wall is used for food to pass through;The stent body includes upper cylinder body and lower cylinder body, the lower cylinder body is surrounded into cylinder by at least three tiles, at least one particle bin is provided on each tile, the particle bin is provided with loading port and clamping area;Swimming ring-shaped air bag is fixedly arranged in the cylinder cavity, located at the intersection of multiple tiles, the swimming ring-shaped air bag is connected with inflation pipeline.Thereby, the adjustable esophageal cardiac particle stent of the application can be taken out to adjust dosage at any time, and can be expanded at cardiac position to adapt to the shape of stomach wall, realize effective irradiation to cardiac position tumor.

This invention relates to a gastric wall fixator, comprising a housing and a puncture assembly. The puncture assembly includes two puncture needles, one of which has a channel, and the other puncture needle has a detachment mechanism movably inserted therein. The housing has an inlet, through which a suture thread passes into the channel. The housing has a push rod connected to the detachment mechanism, and the push rod is slidably connected to the housing. An elastic element is fitted onto the push rod. The advantages of this invention are: by fitting an elastic element onto the push rod, no manual intervention by the doctor is required during operation. Simply releasing the push rod allows the elastic element to automatically push the push rod in the opposite direction using its own elasticity, thereby causing the detachment mechanism to accurately retract into the puncture needle. The repositioning action is continuous and stable, completely avoiding the operational errors and unreliability problems caused by manual repositioning, significantly reducing the surgical risks caused by improper repositioning, and simplifying the operation process and reducing the surgical burden on doctors.

The invention discloses a self-assembled hangover alleviating powder capable of quickly alleviating hangover, protecting gastric mucosa and promoting the hangover alleviating ability of liver, and a preparation method and application thereof, and belongs to the technical field of food health. The preparation method comprises the following steps: carrying out directional enzymolysis on edible fibers to prepare nanofibers, fermenting composite powder of semen hoveniae, rhizoma curcumae longae and radix puerariae by utilizing a composite strain of acetic bacteria and lactobacillus plantarum, and separating precipitate and supernate to respectively prepare an enzyme metabolism system and natural active components. And compounding the nanofibers, an enzyme metabolism system and natural active components to prepare the anti-alcohol composition. According to the invention, a layer of physical protection film is formed on the stomach wall by utilizing the characteristic that the edible nanofiber is quickly self-assembled in gastric acid, so that the direct stimulation of alcohol to the gastric mucosa is reduced; meanwhile, the encapsulated enzyme metabolism system can start to predecompose the ethanol in the stomach under the protection, so that the'front-line 'hangover alleviating is realized, and the liver metabolism load is relieved from the source.

The present application relates to a kind of right-angle cut-in type stomach perforation full layer biopsy forceps, belong to surgical operation instrument technical field, it includes: first clamp bar and second clamp bar, two clamp bars are crossed hinged in middle part by hinged shaft and form scissors-like structure, proximal end is equipped with finger ring;First clamp cup and second clamp cup, respectively, are equipped in the distal end of first clamp bar and second clamp bar, and clamp cup is hollow hemispherical thin-walled shell;Wherein, the bottom central axis of first clamp cup and the distal end axis of first clamp bar are 120 ° to 135 ° cut-in angle α between, second clamp cup and second clamp bar have the same angle of clamping;When two clamp bars are closed, the edge of first clamp cup and second clamp cup mutually adhere to each other, form a closed spherical cavity, and the circular end face of clamp cup mutually butts is equipped with full layer cutting edge.This application enables surgeon to be able to in narrow operation field single hand precision operation, obtains sufficient complete full layer gastric wall tissue and effectively avoids perforation expansion once, significantly improves biopsy quality and surgical safety.

The invention discloses a stomach wall peristalsis detection method, device and equipment based on ultrasonic waves and a storage medium, and relates to the technical field of ultrasonic imaging, the method comprises the following steps: continuously collecting dynamic echo signals of a gastric anterior wall cross section through a high-frame-rate ultrasonic probe, and ensuring high temporal-spatial resolution of original data; analyzing the difference between adjacent frames of images by adopting a phase tracking and cross-correlation algorithm, and converting the stomach wall movement into a quantifiable discrete displacement vector field; next, the discrete displacement field is fitted into a continuous propagation trajectory, and the propelling process of peristaltic waves from the stomach body to the pylorus is visually presented; secondly, key kinetic parameters such as propagation speed and creeping strength are extracted from the trajectory through a multi-scale feature fusion algorithm, and the crossing from qualitative observation to quantitative evaluation is realized; finally, through fusion visualization of vector arrows and color codes, three-dimensional information of the propagation direction, speed and intensity of the peristaltic waves is displayed at the same time, and the detection precision of gastric wall peristalsis is obviously improved.

An implantable medical device for treating reflux disease includes a movement restriction device configured to be anchored to the stomach wall to prevent movement of the lower esophageal sphincter relative to the thoracic diaphragm. The movement restriction device includes a first portion, a second portion, and a first distance element. The first and second portions are configured to be connected to each other to form at least a portion of a functional movement restriction device. The first and second portions are detachable from each other to allow the first and second portions to pass independently through the gastrointestinal tract, and the first distance element is configured to form a space between the first and second portions, the space being configured to allow fibrous tissue ingrowth between the first and second portions.

The application discloses an ultrasonic-based gastric wall peristalsis detection method and device, equipment and storage medium, relates to the technical field of ultrasonic imaging, and the method ensures high space-time resolution of original data by continuously collecting dynamic echo signals of the transverse plane of the anterior wall of the gastric antrum through a high-frame-rate ultrasonic probe; then, the difference between adjacent frames of images is analyzed by adopting a phase tracking and cross-correlation algorithm, and gastric wall movement is converted into a quantifiable discrete displacement vector field; in the next step, the discrete displacement field is fitted into a continuous propagation trajectory, and the propagation process of peristaltic waves from the gastric body to the pylorus is intuitively presented; secondly, key kinetic parameters such as propagation speed and peristaltic intensity are extracted from the trajectory by a multi-scale feature fusion algorithm, and the leap from qualitative observation to quantitative evaluation is realized; finally, the fusion visualization of vector arrows and color coding simultaneously presents three-dimensional information of the propagation direction, speed and intensity of peristaltic waves, and the detection precision of gastric wall peristalsis is relatively obviously improved.

The application discloses an application of an endoscopic continuous suturing device in preparation of a gastric plication suturing medical instrument, and the endoscopic continuous suturing device comprises a suture wire with uniformly distributed barbs, a plurality of titanium clips and a pushing device, the suture wire is 6-10 cm long, and the two ends of the suture wire are respectively provided with a front end connecting ring and a rear end connecting ring; a sheath pipe is arranged at the position close to the rear end connecting ring of the suture wire; the titanium clip is used for clamping and fixing the gastric mucosa tissue and the suture wire; the pushing device is used for tightening the suture wire and comprises a traction steel wire, an inner push tube and an outer sheath tube which are sleeved from inside to outside and slide; a metal hook is arranged at the front end of the traction steel wire; two operation handles are arranged at the rear end of the pushing device and are used for respectively controlling the inner push tube and the traction steel wire to move forward and backward. The gastric mucosa is sutured by the barbed suture wire, the long-term stability of the gastric wall folding is ensured, the barbed suture wire cooperates with the titanium clip to realize step-by-step pre-tightening, and the gastric cavity volume can be accurately controlled.

Systems and methods for treating a gastrointestinal condition of a patient includes minimally invasively implanting a modular or non-modular stimulation system in a patient's treatment site. The treatment site is in or on a gastric wall and electrical stimulation is provided to the gastric wall to improve a function or pressure a lower esophageal sphincter of the patient. Electrical stimulation is provided for a short period of time and treatment efficacy is evaluated through clinical results and patient reporting. If therapy is not effective, stimulation parameters may be changed.

The invention discloses a gastric antrum peristalsis image processing method and system based on a double-lens gastroscope capsule. The method comprises the following steps: acquiring a gastric antrum video sequence shot by the double-lens gastroscope capsule in the stomach of a human body; the double lenses are a first lens and a second lens which are arranged at two axial ends of the gastroscope capsule and are used for respectively acquiring images of a forward view angle and a backward view angle of the capsule; performing motion information processing on the video sequences from the first shot and the second shot to obtain motion features representing gastric wall deformation or image displacement; based on the motion features of the first lens and the second lens, consistency analysis is carried out on the motion directions, change trends and periodic features of the first lens and the second lens in the same time period, and when the motion features of the two lenses meet a preset consistency condition, it is judged that a gastric antrum wriggle event exists in the corresponding time period; and judging time sequence integrity and outputting a result. The accuracy and stability of gastric antrum peristalsis image recognition are improved.

Devices and methods of endolumenal formation of gastric sleeves are described. In some embodiments, a bougie capsule section comprises one or more mechanisms to allow flexing that induces a bend through a suction clamping domain that grabs, positions, and holds body lumen tissue (e.g., gastric wall tissue). In some embodiments, a needle drive is configured to allow longitudinal movement of a helical needle through a suturing space defined by the suction clamping domain, optionally while the suction clamping domain is bent. In some embodiments, the suction clamping domain can insert to the stomach in a collapsed configuration, then expanded once in the stomach. Potentially, this allows grabbing and positioning larger and / or deeper folds of tissue for suturing.