Omeprazole composition and preparing process thereof

Abstract

A compound of the omeprazole and the Sodium Bicarbonate comprise a plurality of enteric-coated pellets composed by the omeprazole and the Sodium Bicarbonate, the capsules composed by Sodium Bicarbonate of any mode. The enteric-coated pellets comprise a pellet core, an isolation layer and an enteric-coated layer. The present invention has the advantages that acid degradation of the omeprazole is resolved by the enteric-coated layer, which prolongs binding between the gastric wall and omeprazole. When Sodium Bicarbonate of any mode neutralizing the gastric acid reaches a certain PH value, the enteric-coated layer can disintegrate and omeprazole can be released. PH value in the stomach remains stable during the releasing process. Another advantage of the present invention is that the compound can be taken at any time when stomachache happens.

Description

technical field [0001] The invention relates to a composition of omeprazole and sodium bicarbonate, and also relates to a preparation method of the composition. technical background [0002] Digestive system disease is one of common frequently-occurring diseases, wherein is based on ulcer disease, and total sickness rate accounts for about 10~20% of population. About 10% of patients with peptic ulcer disease in the United States, 12.3% in Germany; According to a survey in a few areas in my country, the incidence of digestive tract diseases is 11.43%, of which the incidence of peptic ulcer is 4.54%. [0003] With the social development of our country, environmental changes, changes in population structure and people's lifestyles, mainly due to smoking, drinking, emotional stress, drug stimulation, etc., the incidence of peptic ulcer has gradually increased, becoming a common and frequently-occurring disease. It causes great suffering to the patients and leads to a decline in...