532 results about "Peptic ulcer" patented technology

Methods for treating peptic ulcers and methods for treating gastroesophageal reflux disease by oral administration of a botulinum toxin.

The invention provides methods of treating and preventing asthma, laryngitis, symptomatic gastroesophageal reflux disease, pregnancy-induced gastroesophageal reflux disease, noncardiac chest pains, coughing, apnea, dyspepsia, inflammatory bowel disease, irritable bowel syndrome, gastritis, stress ulcers, bleeding peptic ulcers, acute gastrointestinal bleeding, infectious enteritis, collagenous colitis, lymphocytic colitis, chronic diarrhea in immunocompromised patients, esophageal ulcers in immunocompromised patients, idiopathic gastric acid hypersecretion, gastroparesis, gastrointestinal motility disorders, Zollinger-Ellison syndrome, short bowel syndrome, emesis, regurgitation, early satiety, chronic sore throat, abdominal pain, abdominal bloating, nausea, sour stomach, diarrhea, constipation, bacterial infections, refractory ulcers, gastrointestinal disorders induced by NSAIDs, Barrett's esophagus, gastrointestinal disorders caused by steroids, gastrointestinal disorders induced by cholinergic compounds, and fungal or viral-induced ulcers in the gastrointestinal tract by administering a therapeutically effective amount of at least one proton pump to a patient in need thereof. The invention also provides on demand relief of symptoms associated with gastroesophageal reflux disease (GERD), and provides relief from symptoms caused by the consumption of excessive amounts of food and/or alcohol by administering a therapeutically effective amount of at least one proton pump inhibitor to a patient in need thereof. The invention also provides methods for treating parasitic infections, such as malaria, by administering a therapeutically effective amount of at least one proton pump inhibitor to a patient in need thereof.

The present invention discloses a drug 'Jinling Xiaoyan Oral Liquor' made up by using 23 Chinese medicinal materials of toosendan fruit, corydalis tuber, codonopsis root, atractylodes root, white poria and others. It can be used for effectively curing acute and chronic gastritis, peptic ulcer, acute and chronic hepatitis, chelecystitis and pancreatis, etc. and its therapeutic effect is reliable.

Novel thiadiazole compounds are provided, which are effective as proton pumps inhibitors, useful in treating peptic ulcers by inhibition of the proton pump enzyme H+/K+-ATPase. The compounds are 3-substituted 1,2,4-thiadiazolo [4,5- alpha ]benzimidazole and 3-substituted imidazo[1,2-d]-1,2,4-thiadiazoles corresponding to the general formula: where X and Z either represent an optionally substituted benzene ring fused to the diazole nucleus, or represent a variety of independent chemical groupings (hydrogen, lower alkyl, halo, etc.) and Y is selected from a wide range, e.g. heterocyclics and carbonyl groups.

The invention relates to an oral medicinal composition formulation for treating peptic ulcer. The composition comprises esomeprazole, antiacid sodium bicarbonate and a medicinally acceptable carrier, wherein the esomeprazole contains an acid-sensitive proton pump inhibitor; and the antiacid sodium bicarbonate can improve the stability of the proton pump inhibitor. The invention also relates to a preparation method of the medicinal composition. Two active ingredients are integrated into one fixed unit formulation, so that response is quick, a medicinal scheme is simplified in the process of treating the peptic ulcer, and the compliance of a patient is improved.

The invention discloses a compound or its salt shown in the formula (I) and usage of the compound as a potassium competitive acid blocker or a gastric acid secretion inhibitor. The compound has a proton pump (H+/K+)-ATPase inhibitory effect and can be used for preventing, treating and inhibiting diseases related to gastric acid secretion, such as peptic ulcer, zollinger-ellison syndromes, gastritis, erosive esophagitis, reflux esophagitis and symptomatic gastroesophageal reflux diseases.

The invention provides an extraction method of a periplaneta americana extract for treating peptic ulcer, comprising the following steps of:A, crushing, B, soaking, C, extracting, D, primarily concentrating, E, degreasing, and F, secondarily concentrating. According to th invention, extraction is carried out by using the method, lots of proteins contained in periplaneta Americana can be effectively removed, and the degreasing rate is high; and moreover, 90-95% ethanol is used for soaking a coarse powder, so that preservation time is prolonged, and the yield of specific active ingredients for treating peptic ulcer is increased. Due to reasonable control on each process parameter, hydrolysis of the active ingredients for treating peptic ulcer in the extract can be prevented, and the curative effect of the medicine can be improved. With the process disclosed by the invention, the extraction method is low in production cost and high in production efficiency. Clinically applicable preparations (tablets, capsules, mixture, oral liquid, pellets, dripping pills, spray, aerosol, gels and the like) can be prepared by taking the periplaneta americana extract obtained by the method disclosed by the invention and adding proper pharmaceutical auxiliary materials, and are used for (oral-administration or spray) treatment for peptic ulcer.

The invention relates to a TCM prescription capable of replenishing qi to invigorate the spleen, belonging to the TCM field. The technology scheme consists of the following materials in certain ratios: astragalus (30), campanumaea pilosula (12), dried ginger (10), atractylodes rhizome (15), poria (12), dried orangepeel, white cardamom seed (12) and liquorice (9). The medicine has the effect of replenishing spleen and releasing pain. Among the materials, the astragalus, campanumaea pilosula and atractylodes rhizome can replenish spleen and support the healthy energy; the dried ginger, white cardamom seed and dried orangepeel can warm the middle energizer to dispel cold and regulate circulation and release pain; the poria can invigorate spleen to remove dampness and the liquorice can replenish spleen and reconcile all drugs. The combined prescription has the ability of replenishing qi to invigorate the spleen, warming channels and releaving pain. The invention can mainly cure the spleen-yang deficiency patients suffering chronic gastritis, peptic ulcer, chronic enteritis, gastroptosia, malnutrition after gastrectomy, gastrointestinal dysfunction and malabsorption syndromes.

The invention provides a production method for preparing a medicine for treating peptic ulcer by a periplaneta americana extract, comprising the following steps of: A, dissolving, B, diluting, C, filtering and D, filling. A method for extracting the periplaneta americana extract for treating peptic ulcer comprises the following steps of: a, crushing, b, soaking, c, extracting, d, primarily concentrating, e, degreasing and d, secondarily concentrating. In the extraction process, hydrolysis of active substances for treating peptic ulcer in the extract can be prevented, and the curative effect of the medicine can be improved due to reasonable control on each process parameter; by using the medicine prepared by the method, the cure rate of peptic ulcer can achieve more than 55-70%, and the total effective rate of the medicine can achieve 97-99%; and due to addition of glycerol in the medicine solution, the taste of the medicine solution can be improved, and the synergistic effect of the curative effects can be acted together with the periplaneta americana extract for treating peptic ulcer. The production method disclosed by the invention is short in the process route, and capable of reducing production cost and increasing production efficiency.

The invention provides an intragastric floating tablet for periplaneta americana. The intragastric floating tablet is a tablet prepared from periplaneta americana powder or periplaneta americana extracting solution as an active ingredient and an auxiliary material, wherein the weight ratio of the active ingredient to the auxiliary material is 1:(1-30), preferably 1:(2-20), and more preferably 1:19. The intragastric tablet can stay longer in stomach, can well treat helicobacter pylori infection gastritis, peptic ulcer and gastric cancer, and has a wide market prospect.

The invention discloses a traditional Chinese medicine preparation for curing peptic ulcer, and a preparation method thereof. The traditional Chinese medicine preparation is prepared by taking 1 to 10 parts of white peony root, 1 to 20 parts of white atractylodes rhizome, 1 to 20 parts of atractylodes rhizome and 1 to 10 parts of evodia fruit as the basic bulk drugs according to the parts by weight, and also can be combined with 1 to 10 parts of chickens gizzard-membrane, 1 to 20 parts of rhizoma corydalis, 1 to 20 parts of Chinese cinnamon and 15 to 20 parts of auckandia root. Compared with the prior art, the traditional Chinese medicine preparation has the effects of strengthening the spleen and stomach and promoting qi-circulation and relieving pain, and has good treatment effect for the gastric and intestinal diseases with main symptoms of gastric ulcer, doudenal ulcer, gastritis, abdominal pain and abdominal distention; and the traditional Chinese medicine preparation can reduce the dose for the patients to the utmost extent on the premise of ensuring the therapeutic effect of the drug.

The invention provides a Chinese medicinal composition for treating digestive system diseases, which is mainly prepared from Chinese medicinal materials such as phellodendron, spreading hedyotis herb, dried ginger, seabuckthorn and the like according to a certain weight ratio. The Chinese medicinal composition can be prepared into any common oral preparation with appropriate pharmaceutical adjuvants according to the conventional preparation process. The Chinese medicinal composition has the effects of clearing heat and detoxicating and subdhing swelling and stopping ulcer. Clinical observation indicates that the Chinese medicinal composition can be widely used for treating the digestive system diseases, and particularly has a good treatment effect on peptic ulcer.

The freeze dried Lansoprazole sodium sdinjection has Lansoprazole sodium as active component and mannitol or meglumine as excipient in the weight ratio of 15-30 g to 5-50 g. The preparation process of the freeze dried Lansoprazole sodium injection includes the following steps: dissolving Lansoprazole sodium in 15-30 g in injection water of 200-400 ml, dissolving mannitol or meglumine as excipient in 5-50 g in injection water of 100-300 ml, mixing the two kinds of obtained solutions and adding injection water to 2000-3000 ml, adding active carbon in 0.5-1.5 g, filtering with microporous filter membrane, packing in vial, freeze drying under bacteria-free condition, and pressing cap. The freeze dried Lansoprazole sodium injection is used clinically in intravenous drip or intramuscular injection to treat peptic ulcer and other diseases.

The invention relates to stomach medicine and belongs to a pure Chinese herbal medicine preparation. The stomach medicine comprises the following ingredients according to the weight ratio: 250g of paenoiae alba, 120g of citron, 100g of szechwan chinaberry fruit, 80g of rhizoma corydalis, 120g of combined spicebush root, 80g of pseudo-ginseng, 120g of fructus amomi, 70g of elecampane, 120g of radix curcumae, 150g of white atractylodes rhizome, 120g of rhizoma cyperi, 80g of liquorice, 250g of lily, 80g of angelica sinensis, 110g of endothelium corneum gigeriae galli, 80g of galangal, 250g of dandelion and 250g of sculellaria barbata. All recipes are matched, and the effects of nourishing the liver to soften the liver, dredging the hysteresis to harmonize the stomach, invigorating the spleen to supplement qi, and promoting blood circulation to remove blood stasis and relive pain are reached. The whole recipe is mild but not dry and is supplementary and but not sluggish, in addition, the medicine property is gentle, and the stomach medicine can be taken for a long time and approaches to the modern dietary therapy. For peptic ulcer, the six-week ulcer healing rate is 92 percent, the chronic gastritis elimination rate is 93 percent, the stomach medicine has an obvious therapeutic effect on the chronic atrophic gastritis without the therapeutic effect in the prior art and has better therapeutic effects on difficult-to-treat stomach illnesses on which the therapeutic effect of other medicine is poor, and long-term clinical practices show that the stomach medicine does not have any toxic or side effect.

The present invention relates to flavanoid compounds of general formula (X₁) wherein: R₁ is selected from a group consisting of morpholinyl, N-methyl piperizinyl, piperidinyl and N,N′-dimethylamino groups, and n ranges from 3 to 6, and process for preparation thereof. The present invention relates to the demonstration of anti Helicobacter pylori activity and gastric antisecretory activity of semisynthetically designed flavonoid compounds, to be used for the prevention and treatment of gastroduodenal disorders in general and peptic ulcer diseases in particular. The present invention also relates to a hetero-dimeric bi-functional molecule that can be used as monotherapy substituting/replacing/overcoming currently used triple/quadruple therapy, thereby implicating/anticipating/envisaging its commercial applicability.

The present invention discloses a Chinese medicine compound preparation for curing qi stagnation type stomach duct pain and its preparation method. Said compound preparation is formed from 8 Chinese medicinal materials of perilla stem, cyperus root, tangerine peel, citron, Buddha's hand fruit, bitter orange, areca nut and gizzard lining. Said invention also provides the concrete steps of its preparation method, and said Chinese medicine preparation can be used for curing chronic gastritis and peptic ulcer clinically.

The invention discloses a medicine composition for treating peptic ulcer, comprising the following components: 10-20 parts of radix codonopsis pilosulae, 5-15 parts of white atractylodes rhizome, 5-15parts of tuckahoe, 4-12 parts of tuber pinellia, 3-7 parts of rhubarb, 5-15 parts of angelica, 1-5 parts of costusroot, 5-15 parts of tangerine peel, 3-9 parts of villous anomum, 4-12 parts of corydalis tuber, 5-15 parts of salvia miltiorrhiza, 8-16 parts of white peony root, 3-7 parts of rhizoma atractylodis, 4-12 parts of radix bupleuri, 3-9 parts of baikal skullcap root, 3-7 parts of coptis root, 0.5-3 parts of fructus evodiae and 3-7 parts of licorice. The invention also provides a preparation method of the medicine composition, comprising the following steps: weighing each component, grinding, pulverizing, mixing, sieving with a sieve of 100 meshes and preparing various medicament forms which are acceptable in traditional Chinese medicine pharmaceutics. The medicine composition provided by the invention has the characteristics of good curative effect, no toxic or side effect and little possibility of relapse after recovery when being used for treating the peptic ulcer.

The invention discloses a compound omeprazole capsule, and a preparation method and a detection method thereof. The capsule is prepared by: in parts by weight, 20 parts of omeprazole, 1100 parts of sodium bicarbonate, 30 parts of cross linked sodium carboxymethyl cellulose and proper amount of magnesium stearate; or the capsule is prepared by 40 parts of omeprazole, 1100 parts of sodium bicarbonate, 30 parts of cross linked sodium carboxymethyl cellulose and proper amount of magnesium stearate. Aiming at the deficiency of the prior art The formulation, the preparation technology and the detection method of the conventional compound omeprazole capsule are optimized, the compound omeprazole capsule of the invention exhibits more substantial curative effect for diseases comprising peptic ulcer, gastroesophageal reflux disease and the like caused by gastric hyperacidity; a systematic, integrated and effective component discrimination and content determination method is established, thereby the medicine quality is effectively controlled, and thus the clinic curative effect is guaranteed.

The present invention relates to a pure Chinese medicine preparation. Jianwei Kangning Jiaonang capsule for curing the diseases of chronic gastritis, atrophic gastritis, gastro-duodenal ulcer, bile-regurgitational gastritis, functional dyspepsia, peptic ulcer, chronic hepatitis and chronic cholecystitis with obvious therapeutic effect and high cure rate. Said medicine is made up by using 21 Chinese medicinal materials of white peony root, pinellia tuber, poria, unceria stem and thorn, alpinia fruit, fennel fruit and others.

The invention relates to a Chinese medicinal prescription for treating gastric ulcer which comprises the following raw materials (by weight portion): bletilla striata, root of herbaceous peony each 20g, cuttle-bone, stalactite each 30g, Chinese angelica root, dahurian angelica root, rhizoma corydalis, spikenard, cyperus rotundus each 10g, blood clam shell and honey-fried licorice root each15g.

The invention provides an MG53 (mitsugumin53) mutant and a preparation method thereof. The mutant is a serine-site mutant of MG53 protein in a Coiled-coil structural domain, and the mutant results in inactivation of MG53 phosphorylation. Meanwhile, the MG53 protein mutant can be used for preventing or treating diseases related to cellular membrane damage, such as diseases related to myocardial cell injury, diseases related to ulcer, trauma with a wound, particularly a difficult-to-heal wound, intestinal leakage, kidney injury and the like. The diseases related to myocardial cell injury can include one or more diseases related to following symptoms: myocardial ischemia, heart ischemia, heart ischemia/reperfusion injury, myocardial infarction, cardiac failure, arrhythmia and cardiac rupture. The diseases related to ulcer include one or more of following diseases: chronic ulcer, peptic ulcer, diabetic foot ulcer, diabetic foot gangrene and chronic gastric ulcer. Besides, the invention further provides a dry powder preparation, a spray preparation, a gel preparation and an emulsion containing MG53 or MG53 mutant as well as preparation methods of the preparations.

The invention discloses a medicine for treating a peptic ulcer and a preparing method of the medicine. The medicine is mainly prepared from cuttlebone, concha arcae, fritillary bulbs, radix cyathulae, codonopsis pilosula, dendrobe, jasmines, nightshade, radix paeoniae alba, fructus evodiae, rhizoma galangae, fleshfingered citron flowers, trogopterus dung, rhizome bletillae, deer-horn glue, hairyvein agrimony, the roots of three-nerved spicebush, morinda officinalis, fructus amomi, mangnolia officinalis, radix bupleuri, semen coicis, radix curcumae, rheum officinale, pharbitis seeds, fructus chebulae, cinnamon and fructus cannabis according to certain weight proportions. The medicine has the functions of tonifying middle-jiao and qi, hormnizing the stomach and enlivening the spleen, abating fever and soothing the liver, and treating weakness of the spleen and the stomach and deficiency of qi and blood, and is fast in effect taking and good in curative effect when being used for treating the peptic ulcer and the peptic ulcer is not prone to relapse.