18 results about "Peptic ulcer" patented technology

Administration of pentadecanoylcarnitine or pentadecanoic acid is provided for prevention, management or treatment of aggression, allergies, allergic rhinitis, Alzheimer's disease, anxiety and anxiety disorders, amyotrophic lateral sclerosis, arthritis, asthma, atherosclerosis, attention-deficit hyperactivity disorder, bipoloar disorder, brain damage, cancer, cardiovascular disease, cholestatic pruritis, depression, chronic obstructive pulmonary disease (COPD), cocaine abuse, cough, dermatitis, depression, drug-seeking behavior, gastrointestinal disorders, facial erythema associated with rosacea, glaucoma, hepatic diseases, hyperactive bladder, hypersensitivity disorders, hypertension, impulsivity, inflammation, mental disorders and conditions, metabolic disorders, migraines, nasal and sinus congestion, nausea, neuropathic pain with and symptoms of multiple sclerosis, neurological and neuropsychiatric disorders, obesity, obsessive-compulsive disorders, opioid-induced respiratory depression, osteoarthritis, pain, Parkinson disease, pathological gambling, peptic ulcers, schizophrenia, sleep disorders, spinal cord injury, tardive dyskinesia, tics and behavioral problems with Tourette's syndrome; as well as for supporting appetite, cardiovascular health, hematologic health, memory, metabolic health, mood, prolonged REM sleep, renal health, sexuality, sociability and metabolic, hematological, renal, and weight loss.

The invention relates to the technical field of pharmaceutical preparations, in particular to oral in-situ gel and a preparation method and application thereof.The in-situ gel is prepared from, by weight, 0.09-2.5 parts of American cockroach extract, 0.3-3 parts of gel matrix, 86.7-99.4 parts of water and a pH regulator, the in-situ gel is formed by a periplaneta americana extract, a gel matrix and water according to a specific ratio in the presence of a pH regulator, the gel is a clear pale yellow to yellow solution at room temperature, the gel is formed in gastric juice after oral administration as a solution, the gel can be retained in the stomach, more importantly, the burst release of the medicine can be remarkably reduced, and the curative effect of the medicine is improved. The medicine dissolution is improved, and the medicine is ensured to be continuously and slowly released to play a role in treating the peptic ulcer.

The invention discloses a rabeprazole pharmaceutical composition as well as a preparation method and application thereof. The invention provides a rabeprazole pharmaceutical composition, the rabeprazole pharmaceutical composition comprises an active pharmaceutical ingredient and an antacid, and the active pharmaceutical ingredient is selected from one or more of rabeprazole, rabeprazole sodium, other pharmaceutically acceptable salt forms, solvates and hydrates thereof. The rabeprazole pharmaceutical composition disclosed by the invention can inhibit the rabeprazole sodium from being damaged by gastric acid, and is small in side effect, rapid in treatment, relatively good in effect and high in patient compliance; the rabeprazole pharmaceutical composition has the advantages that the rabeprazole pharmaceutical composition is simple in preparation process and good in market prospect, and is an excellent medicine for treating peptic ulcer, and a pharmaceutical preparation can be delivered into the stomach by nasal feeding for some patients who cannot be administered by themselves, so that the effect of treating stomach diseases is achieved.

The invention discloses a urine protein marker for diagnosing helicobacter pylori as well as application, a kit and a risk assessment model of the urine protein marker, and belongs to the technical field of biomedicine. And the protein marker is a combination of PHB1, C20orf202, CP and P0DOX5. Compared with a healthy control, the expression level of PHB1 in a helicobacter pylori patient is lowered, and the expression levels of C20orf202, CP and P0DOX5 in the helicobacter pylori patient are all increased. By detecting expression levels of PHB1, C20orf202, CP and P0DOX5, diagnosis of helicobacter pylori patients can be realized, detection capability and efficiency can be improved, intervention measures can be taken actively, and risks of diseases such as chronic gastritis, peptic ulcer, MALT lymphoma and gastric cancer can be reduced.

The present invention relates to a pharmaceutical or food composition comprising Cinnamomum cassia pretreated extract exhibiting an excellently enhanced pharmacological effect than Cinnamomum cassia extract prepared by a conventional common extraction method of Cinnamomum cassia and extract prepared with Cinnamomum cassia single herb medicine, or a method for preventing, improving or treating gastritis or peptic ulcer using the composition. In addition, the present invention relates to a preparation method of Cinnamomum cassia pretreated extract which is characterized by pretreating Cinnamomum cassia with a non-polar solvent and extracting it with a polar solvent.

A pharmaceutical composition of rabeprazole for treating peptic ulcers, a preparation method therefor and the use thereof. The composition contains a pharmaceutically active ingredient and an antacid, wherein the pharmaceutically active ingredient is selected from one or more of rabeprazole, rabeprazole sodium, and other pharmaceutically acceptable salt forms, solvates and hydrates of rabeprazole.

Provided is a composition of Arctium lappa and Lithospermum erythrorhizon and a method for preparing same. The composition comprises an A. lappa extract and an L. erythrorhizon extract, wherein the A. lappa extract accounts for 90%-10% of the composition, in percentage by weight; the L. erythrorhizon extract accounts for 10%-90% of the composition, in percentage by weight. The composition can be used for preparing a pharmaceutical composition for preventing or treating peptic ulcer or for resisting Helicobacter pylori.

The invention relates to a natural pharmaceutical composition for prevention and treatment of gastric ulcer and a preparation method of the natural pharmaceutical composition. The natural pharmaceutical composition comprises active natural medicinal ingredients. It is composed of turpentine oil, black seed oil, vitamin D and hyaluronic acid. The natural pharmaceutical composition provides a significant synergistic effect, combining anti-inflammatory, antibacterial, and gastroprotective properties, while also ensuring cost-effectiveness and minimal side effects compared to conventional treatments. Beside gastric ulcer is effective in relief of symptoms associated with gastric ulcer. The natural composition has the advantages of accurate curative effects, preparation stability, simplicity and feasibility in process and suitableness for industrial production.

The invention provides an enteric-coated tablet containing rabeprazole sodium and application of the enteric-coated tablet. The enteric-coated tablet containing rabeprazole sodium comprises a tablet core, an isolating layer and an enteric-coated layer. The applicant directly mixes the rabeprazole sodium and the cimetidine to prepare the enteric-coated tablet for treating peptic ulcer, when the concentration ratio of the rabeprazole sodium to the cimetidine is in a proper range, the treatment effect can be obviously improved compared with that of single rabeprazole sodium treatment, and toxic and side effects are not increased. The compound rabeprazole sodium enteric-coated tablet, which is different from the prior art, is prepared by adopting specific auxiliary materials and selecting a proper ratio, and the compound rabeprazole sodium enteric-coated tablet is relatively good in dissolution performance and high in bioavailability, and has a remarkable clinical value.

The invention belongs to the technical field of biological medicines, and particularly relates to an imidazo [1, 2-a] pyridine compound as well as a preparation method and application thereof. The structural formula of the imidazo [1, 2-a] pyridine compound is shown in the specification, and R is selected from sodium ions, potassium ions, calcium ions, magnesium ions, lithium ions or ammonium ions; when R is a sodium ion, a potassium ion, an ammonium ion or a lithium ion, n = 2; and when R is a calcium ion or a magnesium ion, n = 1. The imidazo [1, 2-a] pyridine compound provided by the invention shows high solubility, high dissolution rate and excellent biological activity for inhibiting gastric acid secretion, and provides a new choice for treating gastric acid related diseases such as peptic ulcer.

The present application discloses polymorphs of asiaticoside, a preparation method and medical use thereof. The present application firstly proves that asiaticoside has polymorphism, and provides various crystal forms of asiaticoside suitable for being used as a raw material, which can be used for developing asiaticoside preparations with controllable quality. The present application provides a simple, easy and environment-friendly preparation method of the polymorphs of asiaticoside, which is suitable for large-scale production. The polymorphs of asiaticoside or pharmaceutical compositions containing the crystal forms of asiaticoside can be used for preventing and treating diseases including type I interferon disease, peptic ulcer, Parkinson's disease, ulcerative colitis, systemic sclerosis, liver fibrosis, pulmonary fibrosis, renal fibrosis, Alzheimer's disease, depression, diabetic foot ulcer and refractory wound.

Helicobacter pylori is a leading cause of gastric mucosal inflammation, peptic ulcers, and gastric adenocarcinoma. Emerging antimicrobial-resistant H. pylori has hampered the successful eradication of frequent chronic infections. Additionally, due to the absence of effective vaccines against H. pylori, a safe vaccine is highly demanded. Disclosed herein are innovative Protective Immunity Enhanced Salmonella Vaccine (PIESV) vector strains to deliver and express multiple H. pylori antigen genes. Immunization of mice with a vaccine delivering the HpaA, NapA (also termed Hp-NAP), UreA and UreB antigens, provided sterile protection against H. pylori SS1 infection in 7 out of 10 tested mice. Compared to the control groups that had received PBS or a PIESV with an empty vector, immunized mice exhibited specific and significant cellular recall responses and antigen-specific IgG2c, IgG1, total IgG and gastric IgA antibody titers. Importantly, the mice immunized with the vaccine candidate showed a significant reduction in a load of an unidentified Gram-positive rod-shaped bacteria in their stomach compared to the control groups. In conclusion, a Salmonella Typhimurium-based live vaccine delivering four antigens shows promise as a safe and effective vaccine against H. pylori infection.

The invention relates to a pharmaceutical composition for preventing or treating peptic ulcer. The pharmaceutical composition comprises a compound shown in a formula I or pharmaceutically acceptable salt and a non-steroidal anti-inflammatory drug.

The invention discloses an endoscope injection needle suitable for peptic ulcer, which relates to the field of medical instruments and specifically comprises an endoscope body, a disposable injection needle head, a disposable infusion tube, a connector, an anti-blocking plate and an adjusting grab handle. A conveying cavity for installing the disposable injection needle, the disposable infusion tube and the adjusting grab handle is formed in the endoscope body, the interior of the disposable injection needle is communicated with the interior of the disposable infusion tube, and the adjusting grab handle is arranged on one side of the disposable infusion tube. The use length of the disposable needle head is adjusted through the adjusting grab handle, the pushing rod, the fixing groove and the positioning groove, the pushing rod only needs to slide to the needed position in the positioning groove and then is clamped into the fixing groove in the adjusting process, and the convenience degree is high; secondly, through mutual cooperation of an anti-blocking plate, a non-return block and a reset spring, the effect of preventing the disposable injection needle from being blocked in the process that the endoscope body is placed into the body of a patient is achieved.

The invention relates to the field of medicinal chemistry, relates to a crystal of a benzimidazole compound as well as a preparation method and application thereof, and in particular relates to a crystal of a compound as shown in a formula (I) and a preparation method thereof. The crystal of the compound shown in the formula (I) has good stability and can be applied to preparation of drugs for treating peptic ulcer.

This invention belongs to the field of biomedical technology, specifically relating to an imidazo[1,2-a]pyridine compound, its preparation method, and its applications. The imidazo[1,2-a]pyridine compound has the following structural formula: [Formula omitted for brevity]. Wherein, R is selected from sodium ions, potassium ions, calcium ions, magnesium ions, lithium ions, or ammonium ions; when R is a sodium ion, potassium ion, ammonium ion, or lithium ion, n=2; when R is a calcium ion or magnesium ion, n=1. The imidazo[1,2-a]pyridine compound provided by this invention exhibits high solubility, high dissolution rate, and excellent bioactivity in inhibiting gastric acid secretion, providing a new option for treating gastric acid-related diseases such as peptic ulcers.

The invention belongs to the technical field of health-care tea beverages, and discloses yang-strengthening and stomach-nourishing tea as well as a preparation method and application thereof. The yang-strengthening and stomach-nourishing tea comprises pericarpium citri reticulatae, rhizoma zingiberis, fructus amomi, jasmine flowers, flos magnoliae officinalis, haws, raw malt, medicated leaven, fingered citron and brown sugar. The preparation method of the yang-strengthening and stomach-nourishing tea comprises the following steps: S1, weighing the raw material components according to the weight ratio, uniformly mixing and bagging to prepare a yang-strengthening and stomach-nourishing tea bag brewing agent; and S2, soaking the yang-strengthening and stomach-nourishing tea bag with boiled water, and filtering to obtain a filtrate, namely the yang-strengthening and stomach-nourishing tea. The yang-strengthening and stomach-nourishing tea disclosed by the invention has the effects of warming yang, dispelling cold, invigorating the spleen and reinforcing the stomach, and can effectively relieve and / or treat symptoms such as chronic gastritis, constipation, stomachache and diarrhea, dyspepsia, abdominal distension, peptic ulcer, cold hands and feet, insomnia, dysmenorrhea, hyperplasia of mammary glands, hypertension, hyperlipidemia, weight loss, chronic pharyngitis and the like caused by deficiency-cold of the spleen and the stomach.

Administration of pentadecanoylcarnitine or pentadecanoic acid is provided for prevention, management or treatment of aggression, allergies, allergic rhinitis, Alzheimer's disease, anxiety and anxiety disorders, amyotrophic lateral sclerosis, arthritis, asthma, atherosclerosis, attention-deficit hyperactivity disorder, bipolar disorder, brain damage, cancer, cardiovascular disease, cholestatic pruritis, depression, chronic obstructive pulmonary disease (COPD), cocaine abuse, cough, dermatitis, depression, drug-seeking behavior, gastrointestinal disorders, facial erythema associated with rosacea, glaucoma, hepatic diseases, hyperactive bladder, hypersensitivity disorders, hypertension, impulsivity, inflammation, mental disorders and conditions, metabolic disorders, migraines, nasal and sinus congestion, nausea, neuropathic pain with and symptoms of multiple sclerosis, neurological and neuropsychiatric disorders, obesity, obsessive-compulsive disorders, opioid-induced respiratory depression, osteoarthritis, pain, Parkinson disease, pathological gambling, peptic ulcers, schizophrenia, sleep disorders, spinal cord injury, tardive dyskinesia, tics and behavioral problems with Tourette's syndrome; as well as for supporting appetite, cardiovascular health, hematologic health, memory, metabolic health, mood, prolonged REM sleep, renal health, sexuality, sociability and metabolic, hematological, renal, and weight loss.