The application provides a low-eutectic bio-
adhesive based on mixed polypeptides of
Periplaneta americana and snake slough and a preparation method. Based on the application status of
Periplaneta americana and snake slough in surgical diseases and external use drugs, the bio-
adhesive fuses the optimal proportion of two animal polypeptide extracts and a low-eutectic
solvent, and the three form a uniform composite
system through a low-eutectic effect and a self-
assembly process, is solidified at a diseased part through a preheating-cooling mode and plays a role. The low-eutectic
solvent plays multiple roles as a cosolvent, a plasticizing
excipient, a
penetration enhancer, a
bacteriostatic agent and an auxiliary functional substance. The preparation process is fast, the conditions are mild, special equipment is not needed and the process is easy to scale. The
adhesive formula is simplified to the maximum extent, the raw materials are green, the
system is stable, no other components are specially added, the operation is simple during use and the bio-adhesive is friendly and safe as an auxiliary treatment means. The whole
system fully utilizes the unique activity and
nursing efficacy of various components and can play a synergistic treatment role.