474 results about "Wound healing" patented technology

The invention relates to the technical field of biology, and particularly discloses a recombinant collagen III and application thereof in preparation of gel. The recombinant collagen III is designed by optimizing functional area sequences of human I-type and III-type collagen, the amino acid sequence is shown as SEQ ID No.2, and the recombinant collagen III has the characteristics of high stability, good hydrophilicity and low immunogenicity. The preparation method comprises the steps of expression vector construction, escherichia coli induced expression, affinity chromatography purification and renaturation. The recombinant collagen III can be prepared into a gel dressing and comprises sodium alginate, methylparaben and other components. Experiments show that the gel can effectively promote cell proliferation and has no cytotoxicity; in a mouse skin injury model, the collagen can relieve inflammation, accelerate wound healing and inhibit scar formation, and the effect of the collagen is superior to that of natural human III-type collagen. The invention provides a safe and efficient novel material for wound repair, and is suitable for medical dressings and tissue engineering.

The embodiment of the invention discloses a prediction method, device and equipment for a wound healing process. The method comprises the following steps: acquiring a target image sequence; performing local feature extraction and global feature extraction processing on each target image in the target image sequence by using a first module of a pre-trained prediction model to obtain a local feature vector and a global feature vector; performing time sequence feature extraction processing on the local feature vector and the global feature vector based on different preset extraction periods by using a second module of the pre-trained prediction model to obtain a plurality of time sequence feature vectors; using the pre-trained prediction model to generate healing condition prediction information for the wound part based on the plurality of time sequence feature vectors; and determining a treatment scheme according to the healing condition prediction information.

The invention relates to injectable temperature-sensitive hydrogel loaded with traditional Chinese medicine active exosomes, and belongs to the technical field of clinical treatment of diabetic foot refractory wounds, and the injectable temperature-sensitive hydrogel is obtained by poloxamer 407 hydrogel and a hyaluronic acid loaded composite carrier; the composite carrier body is formed by coating a traditional Chinese medicine active exosome with a coating solution; the traditional Chinese medicine active exosome is obtained by inducing adipose-derived mesenchymal stem cells with a modified astragalus extract. The injectable temperature-sensitive hydrogel is obtained by loading a composite carrier with poloxamer 407 hydrogel and hyaluronic acid, the poloxamer 407 and the hyaluronic acid quickly form a physical barrier on a wound surface after being injected, a moist healing environment is provided, and continuous and slow release of exosome and active ingredients is realized by means of the temperature-sensitive characteristic and the network structure of the poloxamer 407 and the hyaluronic acid, so that the wound healing effect is improved. And over-high local concentration or premature loss caused by sudden release of the medicine is avoided.

The invention discloses an adipose-derived stem cell exosome compound loaded with silver nanoparticles and application of the adipose-derived stem cell exosome compound loaded with the silver nanoparticles, and ADSC-Exos loaded with the silver nanoparticles is developed by integrating AgNPs into an exosome of ADSCs. In vivo, the Exo-AgNPs can accelerate healing of infected wounds by reducing bacterial colonization and promoting collagen deposition, angiogenesis and M2 type macrophage polarization. In vitro, the Exo-AgNPs activates the functions of fibroblasts and vascular endothelial cells, and shows an excellent antibacterial property. In addition, the Exo-AgNPs induces polarization of M2 type macrophages and inhibits secretion of proinflammatory cytokines by activating autophagy. The results show that Exo-AgNPs is expected to become an ideal biological material for treating infected wounds.

The invention discloses a multifunctional hydrogel patch and a preparation method and application thereof.The biological patch comprises decellularized freeze-dried tumor tissue (dFCT) and a hydrogel layer loaded with hair melanin nanoparticles (HNPs), the dFCT is obtained by decellularizing and freeze-drying the tumor tissue, and rich natural extracellular matrix components are reserved; hNPs is extracted from hair and has excellent active oxygen scavenging capacity and photothermal conversion performance; it is preferable that the hydrogel layer is a methacrylated gelatin (GelMA). The patch disclosed by the invention shows a remarkable cell viability promoting effect and antibacterial ability in vitro, and can accelerate wound healing by reducing oxidative stress, inhibiting inflammatory response and promoting angiogenesis in vivo. The patch is simple and convenient in preparation process and natural in component source, has multiple functions of resisting bacteria, resisting oxidation, promoting tissue regeneration and the like, and is suitable for wound repair treatment.

The invention relates to the technical field of medical dressings, in particular to a bacteriostatic and anti-inflammatory wound waterproof spray based on natural plant extracts and a preparation method. The wound waterproof spray is prepared from the following raw materials in parts by weight: 0.1-5 parts of tea tree essential oil, 0.5-10 parts of a honeysuckle flower extract, 5-20 parts of medical-grade polyurethane, 10-30 parts of ethanol, 0.1-3 parts of a rosemary extract and the balance of medical deionized water, wherein the total amount is 100 parts. A sodium alginate-chitosan composite wall material is adopted to carry out microencapsulation encapsulation on a core active substance, so that the stability of the tea tree essential oil and the honeysuckle flower extract can be remarkably improved, the high activity can be kept in the storage period, drugs can be slowly released after the tea tree essential oil and the honeysuckle flower extract are in contact with wounds, long-acting bacteriostasis and inflammation diminishing are achieved, and the wound healing effect is improved. The protection period and the treatment effect of single-time spraying are prolonged, meanwhile, the extremely mild characteristic is ensured, and potential stimulation and damage to wound tissue are avoided.

The invention relates to the technical field of traditional Chinese medicine compositions, and discloses a traditional Chinese medicine composition for wound healing and a preparation method thereof.The traditional Chinese medicine composition used in the early stage comprises 10-12 parts of rheum officinale, 5-6 parts of coptis chinensis, 10-12 parts of scutellaria baicalensis, 10-12 parts of golden cypress, 10-12 parts of corydalis tuber, 6-7 parts of pseudo-ginseng, 5-6 parts of pollen typhae, 4-5 parts of dragon's blood, 10-12 parts of sanguisorba officinalis, 10-13 parts of ramulus mori and 10-12 parts of gallnut; the traditional Chinese medicine composition used in the middle stage is prepared from 10-12 parts of radix astragali, 10-12 parts of radix angelicae sinensis, 10-12 parts of radix salviae miltiorrhizae, 10-12 parts of talc, 10-12 parts of ramulus mori, 10-12 parts of gallnut, 10-12 parts of rhizoma chuanxiong, 4-5 parts of resina draconis, 10-12 parts of frankincense and 10-12 parts of myrrh; the traditional Chinese medicine composition used in the later period comprises 10-12 parts of radix astragali, 10-12 parts of radix dipsaci, 10-12 parts of radix angelicae sinensis, 10-12 parts of rhizoma chuanxiong, 10-12 parts of gallnut, 10-12 parts of ramulus mori, 10-12 parts of radix codonopsis, 10-12 parts of radix salviae miltiorrhizae, 10-12 parts of radix morindae officinalis and 10-12 parts of talc. Wound treatment is divided into three stages, the cure rate of chronic refractory wounds (CRW) can be remarkably increased, inflammatory factors are inhibited, and tissue regeneration is promoted.

The invention belongs to the technical field of medical materials and medicine, and discloses a microneedle patch for accelerating oral mucosa wound healing and a method and application thereof, and the specific preparation method comprises the following steps: (1) preparing a substrate material; (2) preparing a photoactive initiator; (3) loading HS-38 on methacrylated gelatin; and (4) manufacturing a microneedle to obtain the HS-38 loaded microneedle patch for accelerating oral mucosa wound healing. The preparation process of the microneedle patch does not need to depend on expensive instruments and equipment, operation is easy and convenient, and the microneedle patch has the advantages of being accurate in local delivery, noninvasive and painless, controllable in local drug concentration, stable in local drug concentration and the like. The strategy not only provides an effective means for treating chronic oral wounds, but also lays a foundation for realizing clinical transformation and application of medicines, and has wide popularization and application prospects.

The invention discloses a high-moisture-permeability hydrogel nursing patch and a preparation method thereof, and belongs to the technical field of medical supplies. Sodium alginate and gelatin are scientifically compounded to serve as a gel skeleton, functional components such as the aloe extract, the humectant and the penetration enhancer are supplemented, a stable three-dimensional network structure is constructed, the synergistic effect of multiple effects of moisturizing, resisting bacteria, promoting absorption of active ingredients and the like is achieved, and the synergistic improvement of high moisture permeability, antibacterial property and mechanical property of the product is achieved; the prepared nursing patch can quickly and largely absorb exudate at a wound, keep the wound clean and dry, reduce the risk of wound infection by absorbing the exudate, promote wound healing, effectively relieve skin surface wounds and scratches, and avoid skin infection and ulceration caused by the wounds.

The invention provides transparent conductive hydrogel with water response shrinkage, repairability and biocompatibility as well as a preparation method and application of the transparent conductive hydrogel. The conductive hydrogel is formed by taking a dual network formed by polyethylene glycol (PEG)-alpha-cyclodextrin (alpha-CD) and polyethylene oxide (PEO) as a basis and taking polyvinyl alcohol (PVA) as a skeleton as an auxiliary material. Wherein water, as mild stimulation, can destroy directional arrangement of a crystal domain and a molecular chain in PEO so as to trigger efficient contraction, and excellent mechanical repeatability is ensured by combination between alpha-CD and PVA. In addition, the ionic liquid is added, so that the conductive strain sensing requirement is met. By adding glycerol, the gel is endowed with good water-retaining property, and the loss of water is reduced, so that the structural stability and flexibility are maintained. Meanwhile, the glycerin-water binary solvent researched and developed by the research can effectively repair dehydrated gel after long-term use, so that the performance of the gel can be completely recovered. The hydrogel can be used as a dressing for wound healing to promote wound healing. The hydrogel can tightly wrap the surfaces of soft epidermal skin, heart, tendon and other visceral organs in a conformal shape self-adaptive mode, and is used for monitoring physiological signals and motion signals, and meanwhile, the health condition of covered tissues can be visually observed.

The invention discloses a degradable, asymmetric-adhesion and non-swelling Janus hydrogel adhesive as well as a preparation method and application thereof, and belongs to the technical field of functional composite materials and preparation thereof. The problems that an existing Janus hydrogel cannot be degraded, is weak in adhesive force, adheres and is high in swelling are solved. Polyethylene glycol with double bonds, sodium alginate and chitosan are used for physical and covalent cross-linking, a degradable hydrogel substrate is constructed and then soaked in a phosphate buffer solution for swelling equilibrium, then a solution containing chitosan is used for preparing an adhesion coating, and the degradable and asymmetrically-adhered non-swelling Janus hydrogel adhesive is obtained. The adhesive can be applied to the biomedical fields of wound healing anti-adhesion, in-vivo degradability, intestinal repair and the like, and can also be used for adhesion of bioelectronics, epidermal physiological signal monitoring sensors, epidermal muscle fatigue monitoring sensors, rat subcutaneous muscle physiological signal monitoring sensors and muscle fatigue monitoring sensors.

The application provides an injectable tissue repair material and a preparation method and application thereof, and the injectable tissue repair material comprises A component and B component; the A component comprises collagen doped with polyphosphate; and the B component comprises an inorganic salt solution.In the application, the injectable tissue repair material can uniformly cover or fill in uneven or cavity-existed wound surfaces, effectively promotes wound healing, can control the release of polyphosphate, has good stability and can be stored for a long time.

The invention discloses a modified chitosan compound with a function of promoting healing of seawater soaking wounds. The modified chitosan compound DGCS prepared by the invention has good biological activity, has a remarkable promotion effect on cell proliferation, and is enhanced along with the increase of concentration; the inflammation level in cells can be reduced; the healing of a seawater soaking wound can be promoted. An antibacterial experiment shows that the DGCS has good antibacterial activity on escherichia coli, bacillus subtilis, staphylococcus aureus, pseudomonas aeruginosa, enterococcus faecalis, vibrio vulnificus and vibrio parahaemolyticus.

The invention discloses a multifunctional nursing sanitary pad for preventing and treating bedsore, and belongs to the technical field of sanitary pads, the multifunctional nursing sanitary pad comprises a sanitary pad body, and the sanitary pad body comprises an adhesive layer, a skin-friendly layer, an antibacterial layer, a temperature control layer, a waterproof layer, a breathable layer and a bottom wear-resistant layer. According to the invention, the skin-friendly layer is made of a natural fiber material and is soft and attached to the skin, so that friction stimulation is reduced; the antibacterial layer is loaded with chitosan, tea polyphenol plant extract and propolis metabolite, has broad-spectrum antibacterial, anti-inflammatory and wound healing promoting effects, and effectively inhibits bacterial breeding and infection; the temperature control layer contains a microencapsulated phase-change material which can absorb, store and release heat, so that the local skin temperature is kept stable, and bedsores caused by local overheating or moisture are avoided; the waterproof layer is made of a polyethylene material, so that seepage is prevented from reversely permeating to pollute skin; the breathable layer is provided with the breathable holes distributed in a net shape, so that air circulation is remarkably improved; the bottom wear-resistant layer is made of polyester fibers, so that the overall structural strength and durability are enhanced.

A mitochondrial transplantation system includes a mitochondrial and an apoptosis vesicular membrane, the mitochondrial being carried within the apoptosis vesicular membrane. When a system composed of mitochondria and apoptosis vesicles acts on endothelial cells, the targeting and efficiency of mitochondria transplantation are improved, mitochondria autophagy is generated, mitochondria autophagy is reactivated to remove damaged mitochondria of the endothelial cells, the removal of damaged mitochondria is promoted, and the cell functions of the damaged endothelial cells of mitochondria are recovered. The wound healing is favorably promoted. A system composed of mitochondria and apoptosis vesicle membrane is used as an active component to prepare a drug or a medical device for promoting wound healing.

The application belongs to the field of hydrogel biological medicine, and more particularly discloses a kind of supramolecular hydrogel based on natural plant ingredients, preparation and application thereof.The hydrogel only contains polyphenol, polysaccharide and solvent, and the hydrogel is in-situ gelled only by supramolecular interaction between polyphenol and polysaccharide.The hydrogel of the application can be prepared by simple mixing, and can also be in-situ injected by a syringe.The hydrogel preparation process is simple, the raw material cost is low, and the gelation speed is fast;the hydrogel can effectively adhere to the skin, isolate the contact between the wound and the external environment, avoid the invasion of pathogens, at the same time, it is breathable and moisturizing, can provide a suitable moist environment for wound healing, and can completely and quickly release polyphenol.The hydrogel also has excellent antibacterial, antioxidant, anti-inflammatory and pro-angiogenic functions, so it can accelerate wound healing and accelerate bacterial infection wound healing.

The present disclosure relates to 1-(2-(4-cyclopropyl-1H-1,2,3-triazol-1-yl)acetyl)-4- hydroxypyrrolidine-2-carboxamide derivatives and structurally related compounds of formula (I) as VHL inhibitors for the treatment of e.g. anemia (e.g. chronic anemia or anemia associated with chronic kidney disease, dialysis or cancer chemotherapy), ischemia, stroke or injury to the cardiovascular system during ischemia, or for enhancing wound healing, reducing scarring or enhancing angiogenesis or arteriogenesis.

The invention is a composition that can be used to effectively treat or heal bruises that form from injury and / or senile purpura. Specifically, the disclosed composition beneficially heals, moisturizes, and conceals bruised skin. The invention also includes methods of making and using the disclosed composition to aid in wound healing, concealment, and moisturizing.

The present application relates to the technical field of wound repair, and provides a traditional Chinese medicine composition for promoting wound healing and a preparation method thereof.The traditional Chinese medicine composition comprises a first traditional Chinese medicine composition and a second traditional Chinese medicine composition which are applied to the acute phase and the repair proliferation phase.The former comprises naked flower purple perilla extract, nectarine leaf extract, purple perilla extract, dragon's blood micro powder, spironast extract, centella asiatica volatile oil, rhubarb extract, borneol, mussel mucin, medicinal glycerol and purified water.The latter comprises red algae extract, nectarine leaf extract, radix astragali extract, panax notoginseng total saponins, aloe extract, dendrobium officinale extract, sea buckthorn extract, pinctada martensii purified peptide, snail glycosaminoglycan, medicinal glycerol and purified water.The composition can play the roles of antibiosis, anti-inflammation, hemostasis, analgesia and astringency in the acute phase, and can promote angiogenesis, collagen synthesis and epithelial regeneration in the repair proliferation phase, so that the wound is rapidly repaired and healed.

The invention belongs to the technical field of biomedical materials, and particularly relates to an in-vivo degradable multifunctional hemostatic wound healing material as well as a preparation method and application thereof. 5-10 parts of chitosan with the degree of deacetylation greater than 90%, 0.8-1.2 parts of oxidizing bacteria nanocellulose and 0.8-1.2 parts of silk fibroin; dissolving chitosan powder in an acetic acid aqueous solution, and stirring until a clear faint yellow solution is formed, so as to prepare a chitosan solution; the preparation method comprises the following steps: dispersing frozen oxidizing bacteria nanocellulose and silk fibroin in deionized water, and stirring to form a uniform first suspension; and slowly dripping the chitosan solution into the first suspension while stirring at a high speed, centrifugally washing with deionized water, and finally freeze-drying the precipitate. The hemostatic material is excellent in hemostatic performance; a remarkable auxiliary antibacterial function is achieved, and the infection risk can be reduced; the biocompatibility and the degradability are excellent; the gel has double effects of promoting healing and resisting inflammation, and high-quality repair and regeneration of wounds are synergistically accelerated in multiple dimensions.

The invention belongs to the technical field of polyacrylamide hydrogel, and discloses rapid temperature-sensitive response polyacrylamide composite hydrogel as well as a preparation method and application thereof. The preparation method comprises the following steps: dissolving N-isopropylacrylamide NIPAM, acrylic acid AA, [2-(methylacryloyloxy)-ethyl] dimethyl-(3-sulfopropyl) SBMA, an initiator and a chemical cross-linking agent in an amphiphilic cellulose acetate WSCA solution, mixing and stirring until a uniform and transparent hydrogel precursor solution is formed, and carrying out cross-linking polymerization on the obtained hydrogel precursor solution to obtain the hydrogel. Finally, the polyacrylamide composite hydrogel with rapid temperature-sensitive response is generated, and the polyacrylamide composite hydrogel is marked as the WSCA-PNSA composite temperature-sensitive hydrogel. The composite thermosensitive hydrogel provided by the invention has a phospholipid-like characteristic, so that the PNIPAM hydrogel has high thermosensitive driving force while realizing rapid thermal shrinkage, skin functional recovery can be promoted, and rapid and scar-free wound healing is realized.

The invention provides a rhizoma bletillae composition as well as a preparation method and application thereof, and relates to the technical field of traditional Chinese medicine preparations. The core effective component of rhizoma bletillae is rhizoma bletillae polysaccharide, the rhizoma bletillae polysaccharide has the effects of film forming, hemostasis, targeted wound repair promotion and infection prevention, tea polyphenol and rhizoma bletillae are compounded for use, the tea polyphenol and rhizoma bletillae synergistically resist inflammation, the expression quantity of proinflammatory factors IL-1beta, TNF-alpha and IL-6 is reduced by inhibiting NF-kappa B and MAPK signal channels, the inflammatory cascade reaction is remarkably blocked, and the anti-inflammatory effect is achieved. Red, swollen and pain caused by inflammation are effectively relieved, and wound healing is accelerated. In addition, the rhizoma bletillae and the tea polyphenol can also generate a synergistic antibacterial effect, and compared with a single rhizoma bletillae component, the probability of wound infection is further reduced; the compounding use of the rhizoma bletillae and the tea polyphenol also inhibits the excessive deposition of collagen, reduces the scar area, reduces the scar hyperplasia degree, and makes up the blank of only promoting healing and not preventing scars for burns and scalds in the prior art.

This invention belongs to the field of biomedical polymer materials technology, and relates to a method for preparing an injectable thermosensitive composite hydrogel that promotes wound healing, and its application. Polyethylene glycol monomethyl ether is used as a macromolecular initiator, and stannous octoate is used as a catalyst to initiate the bulk polymerization of six-membered cyclic carbonate monomers and their derivatives. After polymerization, coupling is performed via hexamethylene diisocyanate to obtain an amphiphilic block polymer with hydrophilic ends and an oleophilic middle. The block polymer is then dissolved in PBS at low temperature, and a certain proportion of wound-healing nanoparticles are uniformly dispersed in the polymer aqueous solution to obtain the injectable thermosensitive composite hydrogel. This composite hydrogel is a viscous liquid at room temperature and has a viscosity of 34°C. o It rapidly gels in environments above °C, meaning that after injection into the body, it can gel quickly and release nanoparticles in situ to promote wound repair. It also possesses excellent wound-healing capabilities.

This invention relates to a vulnerary multifunctional composition, based on unripe coffee cherries (peel, mucilage, beans and silverskin), seed extract of Trigonella foenum-graecum, with one or more tissue-inducing molecules derived from the secondary metabolites of both plants. The unexpected and surprising ability of this new composition to solve the problems of chronic non-healing wounds addresses a long felt unmet need in the medical arts. Through a multifaceted approach, it combats microbial infections, reduces chronic inflammation, counters oxidative stress, enhances immune responses, promotes angiogenesis, regulates protease activity, stimulates collagen deposition, increases growth factor availability, facilitates cell migration, and prevents persistent infections. These novel integrated therapies represent a breakthrough in addressing macroscopic wound healing while targeting the underlying microscale mechanisms. This invention also relates to methods for preparing, using, and administering the multifunctional composition for timely healing in mammals with various skin lesions.

The present invention provides a use of a functional thylakoid extract, particularly in combination with a physiologically acceptable carrier, for medical purposes in wound healing. The thylakoid extract can be used to treat wounds in the skin or mucosa, such as open wounds or wounds caused by physical trauma. The thylakoid extract can be used to increase the production or level of GM-CSF growth factor and / or G-CSF growth factor in the skin or mucosa of a subject after wounding (e.g., wounds in the skin, mucosa, or corneal epithelium).

The present application belongs to the technical field of biomedical materials, and particularly relates to a composite extracellular trap antibacterial dressing and a preparation method thereof. The composite extracellular trap antibacterial dressing comprises a hydrogel and an extracellular trap loaded in the hydrogel. The antibacterial dressing can actively capture and efficiently kill bacteria including drug-resistant bacteria, is a novel dressing biological sterilization mechanism, has good biocompatibility, and can accelerate wound healing.

The invention relates to the technical field of traditional Chinese pharmacology, and particularly discloses an external liquid containing lime and alum for astringing sores and a preparation method of the external liquid. The external liquid containing lime and alum for healing sores is prepared from the following raw materials: lime, alum, water, a thickening agent, a cortex phellodendri extract, carbonized sanguisorba root powder, borneol and a pH regulator. The preparation method comprises the following steps: S1, preparing lime milk; s2, preparing an alum solution; s3, mixing reaction; s4, performing curing treatment; s5, blending; s6, refining: filtering the mixture obtained in S5, adding borneol and ethylparaben into the filtrate before filtering, and uniformly stirring to obtain the external liquid for healing sore. The external liquid containing lime and alum for healing sores can be used for treating various skin injuries such as skin ulcers, wounds, burns, eczema and postoperative wounds, and has the advantages of efficient astringency and hemostasis, antisepsis and anti-inflammation, promotion of wound healing, good system stability, comfort in use and high safety.

The utility model provides a minimally invasive suturing device for labial labia shaping, which comprises operating forceps, a curved needle is arranged at the end of the operating forceps, a forceps body tail is fixedly arranged at one end of a stress piece on the operating forceps, a connecting piece is fixedly mounted at the other end of the stress piece, and a first forceps foot and a second forceps foot are respectively and fixedly arranged on the connecting piece. The first tweezers foot and the second tweezers foot are clamped at the tweezers portion of the curved needle, a puncture needle is arranged on one side of the tweezers portion, a needle nose is fixedly arranged at the end, away from the puncture needle, of the tweezers portion, and the tweezers portion comprises a first tweezers groove and a second tweezers groove. According to the minimally invasive suturing device for labial labia shaping, the sections of the first tweezers groove and the second tweezers groove are rectangular, the operation tweezers adopt a double-point clamping mode, a curved needle can be tightly clamped, dislocation and looseness cannot occur between the operation tweezers and the curved needle, the curved needle is not prone to axial rotation, accurate suturing of an incision is guaranteed, and the suturing efficiency is improved. The puncture position can be accurately controlled, and good healing of a wound is facilitated.

The present invention provides systems and methods for generally accelerating wound healing, more specifically by supplying oxygen to a wound to accelerate the healing of damaged tissue and / or promote tissue viability. [Solution] The oxygen supply system 200 for the wound 602 includes an outer frame 202 that defines an oxygen outlet. An oxygen generation subsystem is included in the outer frame and coupled to the oxygen outlet. A control subsystem is coupled to the oxygen generation subsystem and is configured to receive humidity information indicating the humidity experienced by the oxygen generation subsystem. The control system then uses the humidity information to control the power supplied to the oxygen generation subsystem in order to control the oxygen flow produced by the oxygen generation subsystem and supplied to a restricted airflow enclosure that passes through the oxygen outlet into contact with the wound.

The invention discloses a traditional Chinese medicine composition for preventing and treating haemorrhoids, a medicine and a preparation method thereof, the traditional Chinese medicine composition is composed of 10-30 parts of red halloysite, 10-30 parts of medical stone and 10-30 parts of calamine, and the active ingredient of the medicine is the traditional Chinese medicine composition. The traditional Chinese medicine composition disclosed by the invention has the effects of astringing intestines and stopping bleeding, detoxifying and removing stasis, removing necrotic tissue and promoting granulation, and relieving itching and astringing sores, and can achieve the treatment effect on haemorrhoids by relieving anus swelling, improving capillary permeability, eliminating inflammation, astringing ulcer wounds and accelerating wound healing. Few medicines are used and the curative effect is obvious.