13 results about "Endoscopic submucosal dissection" patented technology

The present invention relates to an artificial digestive tract tissue for training in endoscopic submucosal dissection (ESD) and a method for manufacturing the same. Specifically, the invention relates to an artificial digestive tract tissue configured to mimic the mucosal layer, submucosal layer, and muscle layer constituting the human digestive tract tissue in a multilayer structure, such that swelling occurs upon liquid injection and a color change occurs due to changes in salt concentration, and to a casting and curing-based hydrogel molding process for manufacturing the same. According to the present invention, the problems associated with existing animal tissue-based ESD training simulators can be resolved, repeated use is possible, and training tailored to the structural characteristics of specific organs (stomach, large intestine, small intestine, etc.) is possible.

To provide a tool or accessory for cleaning a medical device.SOLUTION: The tool or accessory for cleaning a medical device can clean a fluid delivery lumen of an endoscopic submucosal dissection (ESD) knife. The tool or accessory may include a housing with a first portion of the elongate member secured within a first portion of the housing and a second portion of the elongate member extending into a chamber of the housing.SELECTED DRAWING: Figure 1A

A method for preparing a thermosensitive submucosal injection for endoscopic submucosal dissection (ESD), relating to the technical field of regenerative medicine. The specific method involves constructing a novel thermosensitive submucosal injection solution capable of sustained-release hemostatic drugs and growth factors using high-pH chitosan, polyvinylpyrrolidone, calcium ions, and disodium β-glycerophosphate. This injection has very low viscosity, does not require special injection devices, is able to be injected using conventional endoscopic injection needles currently used in clinical practice, and exhibits high injection rate. Additionally, after being injected into the submucosal layer, this injection rapidly forms a high-strength hydrogel under body temperature, more stably supporting the raised state of the mucosal layer to facilitate ESD operations. It also reduces intraoperative and postoperative bleeding, promotes postoperative wound healing, and holds significant clinical practical application value.

Provided are a method for predicting likelihood of developing gastric cancer in a subject, including manufacturing a preparation for measuring the level of mRNA of the genes of CDK1, KDF1, CREB5, and / or AKT2, or the proteins expressed therefrom, measuring with the preparation the level of mRNA of the genes or proteins in a biological sample isolated from the subject, comparing the level of mRNA or protein to that from a control group, and optionally determining that the risk of developing gastric cancer is high when the level of the mRNA or protein in the subject is higher than that from the control group; and a method for predicting prognosis of early gastric cancer patients after treatment by endoscopic submucosal dissection, including the same steps, where the methods have high accuracy and enable the prediction via a one-time measurement by multi-plex PCR with a single tissue sample.

The application discloses an endoscope-based wound treatment method and an endoscope system. The method comprises the following steps: acquiring a first endoscope image after endoscopic submucosal dissection; identifying an unclosed wound in the first endoscope image to obtain wound information, wherein the wound information at least comprises a wound size, a wound position and a wound shape, the wound size is used to indicate the length and width of the unclosed wound, the wound position is used to indicate the coordinates and range of the unclosed wound in the first endoscope image, and the wound shape is used to indicate the edge shape of the unclosed wound; determining a first closing operation scheme for the unclosed wound according to the wound information; and outputting first prompt information according to the first closing operation scheme. The application can realize automatic identification of a wound area, accurately evaluate the current wound treatment condition according to the identified wound information, and then give a prompt to the wound treatment condition, thereby improving the treatment efficiency of the wound.

The invention discloses a preparation method of a chemically assisted cross-linked chitosan temperature-sensitive gel submucosal injection for endoscopic submucosal dissection, and belongs to the technical field of regenerative medicine. According to the specific method, chitosan, beta-sodium glycerophosphate, sodium dihydrogen phosphate, acetic acid, a chemical auxiliary cross-linking agent and a medical coloring indicator are utilized to construct the novel chemical auxiliary cross-linked chitosan temperature-sensitive gel submucosal injection. The injection is very low in viscosity, does not need a special injection device, and can be injected by using a conventional endoscope injection needle which is clinically used at present. Meanwhile, after the injection is injected under the mucous membrane layer, high-strength hydrogel can be rapidly formed under the action of body temperature, the upheaval state of the mucous membrane layer can be stably supported, ESD operation is facilitated, and the risk of perforation and bleeding is reduced. Particularly, a synergistic dynamic proton ionization response system is established in the injection by sodium dihydrogen phosphate and acetic acid, so that the deprotonation speed of chitosan is remarkably slowed down, and the chemical auxiliary crosslinking speed is slow, so that the chemical auxiliary crosslinking does not influence injection, mucous membrane lifting and electric resection of the injection in the ESD operation, and the crosslinking degree is gradually improved after the ESD operation. The chemical auxiliary crosslinking can significantly improve the adhesion stability of the gel layer on the postoperative wound surface, form a stable wound surface sealing protection gel layer, and effectively delay the degradation of the gel layer in vivo, especially in the gastric juice environment, so that the adverse effect of the external environment on the postoperative wound surface healing can be effectively reduced, and the postoperative wound surface healing effect is improved. And the degradation of the gel layer is more matched with the tissue repair, so that the wound healing is promoted. Therefore, the chemically assisted cross-linked chitosan temperature-sensitive gel submucosal injection has very important clinical practical application value.

The invention belongs to the technical field of biological materials, and particularly relates to a preparation method and application of agglomerate powder capable of being delivered under an endoscope for preventing digestive tract stenosis after endoscopic submucosal dissection. The preparation method comprises the following steps: dissolving a polysaccharide compound in a solvent, and adding unsaturated carboxylic acid anhydride for graft modification; respectively dissolving the modified polysaccharide and the hydrophilic polymer, and mixing; preparing a suspension containing a polyphenol compound and a therapeutic active substance; and mixing the mixed solution and the suspension until phase separation, collecting a condensed phase, and performing freeze drying and grinding treatment to obtain condensed powder. The aggregate powder has excellent wet tissue adhesion capacity, can be directly delivered to the surface of a wound through an endoscope working channel, forms a protective barrier, slowly releases treatment active substances, inhibits local inflammatory response and tissue fibrosis, effectively prevents digestive tract endoscopic submucosal dissection postoperative stenosis, and is particularly suitable for preventing esophageal ESD postoperative stenosis.

This invention provides a gel material for hemostasis and promoting healing of the digestive tract mucosa, and its preparation method, belonging to the field of biomedical materials technology. The material consists of two separately packaged solutions: Solution A contains sodium alginate with an amination degree of 0.5-2.0 mmol / g, RGD peptide, quaternized chitosan, growth factors, and indigo carmine; Solution B consists of liposome microspheres encapsulated with pre-chelated calcium ions. This invention achieves controllable cross-linking through a "dual regulation mechanism": modified sodium alginate adjusts the cation capture sensitivity, and liposomes control the ion release rate, allowing the gel formation time to be precisely controlled within 30-60 seconds, solving the needle blockage problem caused by the instantaneous solidification of traditional gels. This gel combines physical support, immediate hemostasis, and long-term healing promotion, and has good biocompatibility, making it particularly suitable for mucosal elevation and postoperative repair in endoscopic submucosal dissection (ESD).

A robotic device is provided.SOLUTION: The robotic device includes an articulatable elongated member having a proximal end and a distal end, the distal end being steerable via a first drive mechanism, an articulatable imaging instrument removably coupled to the articulatable elongated member via a first lumen of the articulatable elongated member and having a camera located at a distal portion thereof, and an articulatable instrument removably coupled to the articulatable elongated member via a second lumen, movement of the articulatable instrument being captured by the camera of the articulatable imaging instrument.SELECTED DRAWING: Figure 2

1. The name of the design product: electrotome for digestive tract endoscope surgical instrument control system. 2. The use of the design product: endoscopic submucosal dissection for digestive tract endoscope surgical instrument control system. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view. 5. The length of the elongated part of the design product adopts the omission drawing method.

In endoscopic submucosal dissection, the blood vessels contained within the submucosa are visualized. [Solution] An information processing device according to one embodiment of the present invention includes a highlighting unit that highlights the region of blood vessels contained in the submucosa in the image of an endoscopic system used in endoscopic submucosal dissection for early gastrointestinal malignant tumors.

A pathological evaluation method for endoscopic submucosal dissection comprises the steps in which: an analysis device receives an input of a Haematoxylin and eosin (H&E) stained image of a specimen; the analysis device identifies a region of interest by inputting the H&E stained image to a segmentation model; and the analysis device evaluates a submucosal invasion state of the specimen according to the ratio of a tumor region in a specific muscularis mucosae region of the region of interest.

The invention discloses a preparation method of a temperature-sensitive submucosal injection based on freeze-dried particles for endoscopic submucosal dissection, and belongs to the technical field of regenerative medicine. The injection comprises chitosan-polyvinylpyrrolidone freeze-dried particles and beta-sodium glycerophosphate freeze-dried particles, can be stored for a long time, is convenient to transport and is simple and convenient to use. When in use, the two freeze-dried particles can be respectively and quickly dissolved in low-temperature injection water, and the low-temperature submucosal injection is formed after the two freeze-dried particles are mixed. The low-temperature injection is very low in viscosity, does not need to use a special injection device, can be used for submucosal injection by using a conventional endoscope injection needle which is clinically used at present, and is high in injection speed. Meanwhile, after the low-temperature injection is injected under the mucous membrane layer, high-strength hydrogel can be rapidly formed under the action of body temperature, the upheaval state of the mucous membrane layer is more stably supported, ESD operation is facilitated, intraoperative and postoperative bleeding can be reduced, postoperative wound healing is promoted, and the low-temperature injection has important clinical practical application significance.