35 results about "Endoscopic submucosal dissection" patented technology

The present invention provides apparatus and methods for performing endoscopic mucosal resection and endoscopic submucosal dissection of tissue. In a first embodiment, a hood member having a hood portion and a lever portion is provided. The hood portion is adapted to be disposed over a distal region of an endoscope. A portion of the lever portion is configured to be inserted beneath a section of mucosal tissue having a lesion, and the lever portion is configured to be rotated or otherwise maneuvered to lift the mucosal tissue in an upward direction, thereby facilitating removal of the tissue comprising the lesion. Optionally, a surgeon may advance a needle knife through the endoscope and lever portion to further incise submucosal tissue while the lever portion is disposed beneath the lesion. If desired, a flushing fluid may be provided to a target site during the procedure.

The invention belongs to the fields of high polymer materials and medical equipment and relates to a submucous injection material composed of physical cross-linked hydrogel and an application thereof to preparing injection materials for endoscopic submucosal dissection. The submucous injection material consists of an amphiphilic block copolymer, a solvent which takes water as a main body, and a coloring indicator, wherein the amphiphilic block copolymer is formed by taking polyethylene glycol (PEG) as a hydrophilic block and taking degradable polyester as a hydrophobic block. The material has thermal induced gel-forming properties; when the temperature is lower than a sol-gel transition temperature, a water system presents low-viscosity solution, has good injectable property, and can be subjected to endoscopic injection to the submucosal position so as to spontaneously form in-situ physical hydrogel under the body temperature, good gel morphology is maintained during an ESD operation, the uplift height and duration of the submucous injection material are superior to those of an existing pure liquid material, and the ESD operation is smoothly performed.

The present invention provides apparatus and methods for performing endoscopic mucosal resection and endoscopic submucosal dissection of tissue. In a first embodiment, a catheter having proximal and distal ends and a balloon disposed near the distal end of the catheter is provided. A portion of the distal end of the catheter is configured to be inserted beneath a section of mucosal tissue having a lesion, and the balloon is configured to be inflated to lift the mucosal tissue in an upward direction, thereby facilitating removal of the tissue comprising the lesion. Optionally, a surgeon may advance a needle knife through the catheter to further incise submucosal tissue while the balloon is in the inflated state. If desired, a flushing fluid may be provided to a target site during the procedure.

A kit and a method for delivering an injectable solution to a tissue treatment site are provided. The kit includes a housing having a chamber, a proximal portion and a distal portion. An injectable solution having a viscosity greater than about 10,000 cP is provided in the chamber. A plunger is provided in the proximal portion of the housing. The kit also includes a pressure gauge operably connected to the housing. The kit may also include a handle connected to the housing and a plunger advancing member having a plunger handle connected thereto provided separate from the housing. The kit may also include an inner shaft provided separate from the housing and having a proximal end portion configured for operably connecting with the distal portion of the housing for receiving the injectable solution therethrough and a distal end of the shaft configured for insertion in to the tissue treatment site.

The invention belongs to the fields of high polymer materials and mechanical instruments and relates to a hydrogel composition for gastrointestinal submucosal injection and an application of the hydrogel composition. The hydrogel composition provided by the invention is composed of a mixture, a solvent and a color indicator, wherein the mixture is composed of two or more segmented copolymers; water is taken as a main body by the solvent; a water solution of the hydrogel composition has thermotropic gelatinization property; a polymer mixture can be dissolved in water at a room temperature or a low temperature to form a low-viscosity solution; the water solution of the mixture can be subjected to reversible sol-gel transition along with temperature rise. The hydrogel composition material provided by the invention can be applied to preparation of the composition material for endoscopic submucosal dissection and is capable of reducing complications such as perforation and bleeding in an ESD operation when applied to ESD; the operation safety is improved; the operation difficulty is reduced; the time required for finishing operation is shortened; and convenience is provided for ESD diagnosis and treatment of cancers such as colon cancer and rectal cancer.

A treatment instrument for an endoscope is provided that is suitable for cutting submucosa in endoscopic submucosal dissection. The treatment instrument for an endoscope includes a treatment portion having a cutting unit at a tip of an insertion portion that is to be inserted into the body. The main unit of the treatment portion is formed in a sawtooth shape having a peak portion and a valley portion. An electrode plate serving as the cutting unit is provided in the valley portion.

The invention discloses a high-frequency incision knife with an accurate fixed-length knife bit for an endoscope, which comprises the knife bit and a core rod. A handle is arranged at the tail end of the core rod, one portion of the knife bit is located in the core rod while the other portion of the knife bit extends out of the core rod, and the knife bit can retractably move in the core rod. An insulation outer tube is arranged on the portion, which extends out of the core rod, of the knife bit, the core rod is provided with a control part for controlling movement of the knife bit, a clamp part is disposed on the outer wall of the knife bit located in the insulation outer tube, a limiting block matching with the clamp part is disposed on the inner side of the insulation outer tube, as the clamp part matches with the limiting block, the longest distance of the knife bit extending out of the core rod can be controlled, and further the length of the knife bit is fixed accurately. The high-frequency incision knife with the accurate fixed-length knife bit for the endoscope is simple in structure and flexible in operation, and is safe and reliable, as the high-frequency incision knife is provided with a positioning mechanism, the length of a portion incised by the incision knife is fixed accurately, and the high-frequency incision knife is favorable for increasing ESD (endoscopic submucosal dissection) surgery efficiency. Compared with a traditional incision knife, the high-frequency incision knife has the advantages that surgery risks can be reduced, intraoperative complications are decreased, and sufferings of patients are relieved.

The invention discloses an electric knife bit for endoscopic submucosal dissection, and a preparation method thereof. The electric knife bit is composed of a core layer and a shell layer. The core layer is wrapped with the shell layer. The preparation method of the electric knife bit comprises the steps that 316L stainless steel and ZrO2 ceramic are selected as a shell layer material and a core layer material correspondingly; shell layer material feed and core layer material feed are obtained through mixing and pelletizing; then the shell layer material feed and the core layer material feed are sequentially injected into a mold cavity through a co-injection forming technology to obtain a product green body; and then a binder in the green body is removed through solvent degreasing and thermal degreasing technologies, and finally a structural and functional integration electric knife bit product is obtained through co-sintering densification. According to the electric knife bit, a powderco-injection forming technology is adopted, the processing efficiency is high, the production cost is low, a composite material with the excellent shell layer and core layer binding property and thestable quality is prepared, the problems such as poor product performance, low efficiency and high cost in existing technologies are solved, and the preparation method is suitable for preparing the electric knife bit for the endoscopic submucosal dissection.

A treatment instrument for endoscope that is suitable for cutting submucosal layer in endoscopic submucosal dissection is provided, and the treatment instrument for endoscope has a treatment section at a distal end of an insertion section which is inserted in a body. The treatment section includes a conductor that is connected to a high-frequency source, and is configured to have a sandwich structure in which the conductor is sandwiched between a non-conductor on the distal end side thereof and a non-conductor on a proximal end side thereof. The conductor is formed to be exposed in a strip-shape at a side surface of the treatment section, and a lateral movement of the treatment section causes a cutting of a submucosal layer with the conductor to be performed.

The invention discloses a temperature sensitive hydrogel. The temperature sensitive hydrogel is a PLGA-PEG-PLGA triblock copolymer, wherein a mass ratio of lactide to glycolide in the above PLGA copolymer is 2-4:1, and a ratio of the total mass of lactide and glycolide to PEG is 1-2:1. The invention also discloses a preparation method of the temperature sensitive hydrogel, and an application of the temperature sensitive hydrogel in endoscopic submucosal dissection. The temperature sensitive hydrogel can increase the mucosal protrusion height and prevent the diffusion of a musical lower layer as a marker carrier in the endoscopic submucosal dissection, so the cutting completeness in the endoscopic submucosal dissection is ensured, the perforating and bleeding risks are reduced, the operation safety and efficiency are improved, and the pains of patients are mitigated.

The invention discloses a traction instrument for an ESD (endoscopic submucosal dissection) surgery. The traction instrument comprises a guide handle, an upper cover, a guide ball, an outer sleeve, aguide tube and a traction clip, wherein the outer sleeve, the guide tube and the traction clip are sequentially connected in the axial direction, the guide ball is fixedly connected with the outer sleeve, and the upper cover sleeves the periphery of the guide ball and is set to be able to rotate along the spherical surface of the guide ball; a push-pull cable is connected to the guide handle, sequentially penetrates through the upper cover, the guide ball, the outer sleeve and the guide tube in the axial direction and then is connected with the traction clip, and the guide handle can reciprocate in the axial direction of the ush-pull cable; and a plurality of traction wires are connected to the upper cover, and each traction wire crosses the guide ball along the periphery of the guide balland is connected with the tail end of the guide tube. The traction instrument can have a function of controlling rotation, bending, opening and closing of the head traction clip at the same time, andhas wider applicability.

The present invention relates to a pharmaceutical composition in form of emulsion or microemulsion and the use thereof as aid during endoscopic procedures in which it is injected in a target tissue in order to form a cushion. More in details, the invention relates to a method for performing an endoscopic procedure, which comprises injecting said pharmaceutical composition in form of emulsion or microemulsion in a target tissue of a patient, in order to form a cushion, which cushion is then optionally subjected to an endoscopic surgical procedure, such as a resection.

In an endoscopic submucosal dissection (ESD), electrodes inserted via an endoscope are used to cut and / or coagulate the tissue. For the operation to succeed, it is essential to determine the absolute position of the electrodes within the tissue. However, poor viewing conditions and technical limitations make the correct determination of the position extremely difficult. The present invention therefore proposes to make available an electrosurgical instrument which comprises a protective tube, to be inserted into a working channel of an endoscope, and an electrode. A control element is used to move this electrode in a distal direction and a proximal direction inside the protective tube, wherein the electrode, by being moved in the distal direction, can be brought into a deployed position in which the electrode at least partially protrudes from a distal end of the protective tube. The distal end of the protective tube has a closure element with an opening for the passage of the electrode, wherein the opening of the closure element, for guiding and / or cleaning the electrode, has a maximum internal diameter smaller than the internal diameter of the protective tube.

The present invention provides apparatus and methods for performing endoscopic mucosal resection and endoscopic submucosal dissection of tissue. In a first embodiment, a catheter having proximal and distal ends and a balloon disposed near the distal end of the catheter is provided. A portion of the distal end of the catheter is configured to be inserted beneath a section of mucosal tissue having a lesion, and the balloon is configured to be inflated to lift the mucosal tissue in an upward direction, thereby facilitating removal of the tissue comprising the lesion. Optionally, a surgeon may advance a needle knife through the catheter to further incise submucosal tissue while the balloon is in the inflated state. If to desired, a flushing fluid may be provided to a target site during the procedure.

The invention belongs to the field of high polymer materials and medical equipment, and particularly relates to a formula and a preparation technology of a submucosal injection sodium hyaluronate solution for an endoscope. According to the formula of the sodium hyaluronate solution, the sodium hyaluronate solution is prepared from sodium hyaluronate, sodium chloride, sodium hydrogen phosphate, sodium dihydrogen phosphate, methylene blue and water for injection. The preparation technology of the sodium hyaluronate solution includes the steps that firstly, sodium chloride is stirred and dissolved in a burdening tank, then sodium hyaluronate is added, temperature is raised to 40 DEG C, and stirring is performed; sodium hydrogen phosphate and sodium dihydrogen phosphate are sequentially added in, and stirring continues; secondly, the pH value of material liquid is measured; the pH value of the material liquid is adjusted to reach 7.0-8.0; thirdly, methylene blue is added and stirred, water is supplemented, and volume is metered; fourthly, filtering is performed through a microfiltration membrane ; fifthly, the mixture is encapsulated in an ampoule or a glass bottle and sterilized with steam at the temperature of 121 DEG C for 15 min, and the submucosal injection sodium hyaluronate solution is obtained. The sodium hyaluronate solution is used for endoscopic submucosal dissection (ESD) and is injected below a gastrointestinal mucous membrane, lesions can be fully swelled, a submucosal liquid cushion is formed, a submucosa and a muscular layer can be effectively separated, and bleeding, perforation and other complications can be reduced while electroexcision is facilitated.

The invention discloses a preparation method of a liquid collagen filling agent. A principle component of the filling agent is an I type collagen, wherein the collagen has an integral natural three-screw structure, and the hydroxyproline content is more than 9%. I type nontoxic crosslinked collagen powder prepared from the I type collagen is particularly applicable to preparation of the liquid collagen filling agent. The prepared liquid collagen filling agent can serve as a swelling agent of endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD), is reasonable in swellingheight and supporting time duration, has a certain hemostasis effect during the operation and has an excellent application effect; and moreover, the liquid collagen filling agent can serve as a softtissue filling dilation agent, is finally degraded in vivo and can be completely absorbed by tissues.

The invention discloses preparation of a liquid collagen submucosal filler. Collagen is of type I and has a complete natural triple helix structure, and a hydroxyproline content is greater than 11%. The type I collagen and type I collagen powder prepared from the type I collagen are particularly applicable to preparation of the liquid collagen submucosal filler; and the obtained liquid collagen submucosal filler can serve as a rising agent of a focus in endoscopic mucosal resection or endoscopic submucosal decollement and a repair material of a wound in an operation process, is reasonable in support time span, can be absorbed by a tissue completely, has hemostasis and repair functions at the same time, and has a very good application effect.

The invention discloses a mucous membrane tractor comprising an endoscope fixing part, an instrument lifting part, a swinging arm and a traction part, wherein the endoscope fixing part can be installed at a distal end head of an endoscope; the instrument lifting part can be used for installing a surgical instrument; one end of the swinging arm is movably connected with the endoscope fixing part, and the other end of the swinging arm is movably connected with the instrument lifting part; and the distal end of the traction part is connected with the instrument lifting part. The technical schemeprovides endoscopic surgeons a method for controlling more instruments to be used in a matching way by utilizing the traditional endoscope, meets requirements on multiple-instruments matching operation of the surgeons to a certain extent, achieves certain effects of reducing labor intensity of the complex and time-consuming surgeries encountered currently, such as ESD (Endoscopic Submucosal Dissection) and the like, greatly shortening surgery time and improving safety and operability, facilitate popularization of some complex and time-consuming surgeries to primary hospitals and plays the role of relieving the conditions of poor access to and high cost of medical treatment at present to a certain extent.

The invention relates to a magnetic anchoring device for endoscopic submucosal dissection and a using method of the magnetic anchoring device. The magnetic anchoring device provided by the invention includes a target magnet and an anchoring magnet capable of attracting the target magnet, wherein the target magnet includes a magnetic core and a target magnet shell, and the magnetic core is nested in the target magnet shell. The magnetic anchoring device is simple in operation, reliable in mucosa pulling effect and capable of flexibly adjusting a pulling direction and a pulling force.

The invention discloses a method for intelligently identifying and recording a polyp extirpating video of endoscopic submucosal dissection. The method comprises: capturing feature pictures of the operation video from the video in batches; establishing and training a neural network model; traversing the video again to verify the neural network model; producing prediction picture, comparing pictureswith relatively high similarity in the predicted pictures; archiving and storing the pictures without similarity in a data set; training the convolutional neural network again by using the archived data set; inputting the real-time endoscope video into the high-precision neural network model to be used for reading and classifying pictures in the operation process and recognizing specific operation instruments in the video so as to effectively record the video, and the method has the beneficial effect of being rapid and accurate in recognition.

The invention discloses a temperature-sensitive hydrogel, which is a PLGA-PEG-PLGA triblock copolymer, wherein the mass ratio of lactide to glycolide in the PLGA copolymer is 2-4:1, the The mass ratio of the sum of lactide and glycolide to the mass of PEG is 1-2:1. The invention also discloses a preparation method of the thermosensitive hydrogel and its application in endoscopic submucosal dissection. The temperature-sensitive hydrogel of the present invention, when used as a marker carrier in endoscopic submucosal dissection, can increase the height of the mucosal bulge and prevent the diffusion of markers in the submucosa, thereby ensuring complete cutting during endoscopic submucosal dissection , reduce the risk of perforation and bleeding, improve the safety and efficiency of surgery, and reduce the pain of patients.

The invention provides a pharmaceutical composition in form of emulsion or microemulsion for use in an endoscopic procedure, preferably said endoscopic procedure comprising the administration of said pharmaceutical composition to a human with the aim of improving and facilitating the resection of the lesion by raising the area where the lesion is located. The invention herein disclosed provides a method for performing an endoscopic procedure, said method preferably comprising the administration of a pharmaceutical composition in form of emulsion or microemulsion to a human.

The invention discloses an apparatus for preventing esophageal lumen stenosis after ESD (endoscopic submucosal dissection). The apparatus comprises an air sac and an inflation tube, wherein the air sac is in the shape of a tube in the inflation condition, a magnetic force closure device is arranged at the bottom of the air sac, the inflation tube extends into a lumen of the air sac from the magnetic force closure device, and fixing rings are arranged at outside edges of the top and the bottom of the air sac; the magnetic force closure device comprises two or more sealing slices and an inflation hole, wherein the two or more sealing slices are connected in a magnetic adsorption manner, and the inflation hole is adapted to the inflation tube; and a plurality of exhaust holes are formed in the periphery of an exhaust end of the inflation tube, and are in helical arrangement. The apparatus disclosed by the invention can well support an esophagus, can contribute to autonomous eating and drinking of a patient, and is reliable to fix.

The invention relates to a degradable stent for preventing and treating esophageal stenosis, and belongs to the technical field of medical instruments. The degradable stent includes a film pasting material of genipin cross-linked chitosan collagen loaded with PLGA / triamcinolone acetonide sustained-release microspheres and a degradable stent, wherein a film pasting material of genipin cross-linked chitosan collagen loaded with PLGA (poly (lactic-co-glycolic acid)) and triamcinolone acetonide sustained-release microspheres is arranged on the periphery of the degradable stent. The degradable stent disclosed by the invention is mainly used for preventing and treating the benign stenosis of the esophagus, in particular to a series of benign stenosis problems such as postoperative wound surfaces of endoscopic submucosal dissection (ESD) for treating early esophageal cancer, postoperative anastomotic stoma stenosis of the thoracic surgery esophagus and scar contracture stenosis after esophageal chemical injury.

The invention relates to an endoscopic submucosal dissection instrument with a swallow-tail form tool bit. The endoscopic submucosal dissection instrument comprises the openable swallow-tail form toolbit, a transmission wire, a fixed handle, a slidable handle, a rotatable handle and an electric connecting device, the rotatable handle drives the swallow-tail form tool bit to rotate, the front endof the transmission wire extends out of the fixed handle and is connected with the swallow-tail form tool bit, the rotatable handle and the slidable handle are mounted on the fixed handle, the slidable handle is fixedly connected with the transmission wire, so that opening and closing of the swallow-tail form tool bit are controlled by the slidable handle, the rotatable handle is connected with the transmission wire through a vertical transmission structure, a cutting edge of the swallow-tail form tool bit is positioned at the outer side edge of a blade, and the swallow-tail form tool bit is electrically connected with the electric connecting device through the transmission wire. When the swallow-tail form tool bit is closed, an opening can be formed in a mucous membrane, two sides can besimultaneously cut open by the cutting edge after the swallow-tail form tool bit is opened, the electric connecting device is connected with a power supply, cutting can be accelerated, blood coagulation effects are achieved, and a dissection view is clearer.

A liquid composition includes: An alginic acid or a pharmaceutically acceptable salt thereof and a colloidal polysaccharide. The liquid composition of the present invention is suitable as a medical biomaterial for tissue repair to elevate mucosal tissues of the stomach and intestines during endoscopic resection. More specifically, the present invention relates to a submucosal injectable pharmaceutical liquid composition for use in endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD) for medical applications, including alginic acid having a weight average molecular weight of 100,000 to less than 200,000 or a pharmaceutically acceptable salt thereof and a colloidal polysaccharide. The liquid composition of the present invention is suitable for use as a preparation for submucosal local injection that can maintain mucosal elevation for a long time when injected during endoscopic mucosal resection or endoscopic submucosal dissection.

The invention discloses a preparation method of a liquid collagen filling agent. A principle component of the filling agent is an I type collagen, wherein the collagen has an integral natural three-screw structure, and the hydroxyproline content is more than 9%. I type nontoxic crosslinked collagen powder prepared from the I type collagen is particularly applicable to preparation of the liquid collagen filling agent. The prepared liquid collagen filling agent can serve as a swelling agent of endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD), is reasonable in swellingheight and supporting time duration, has a certain hemostasis effect during the operation and has an excellent application effect; and moreover, the liquid collagen filling agent can serve as a softtissue filling dilation agent, is finally degraded in vivo and can be completely absorbed by tissues.

The invention discloses a mucous membrane tractor comprising an endoscope fixing part, an instrument lifting part, a swinging arm and a traction part, wherein the endoscope fixing part can be installed at a distal end head of an endoscope; the instrument lifting part can be used for installing a surgical instrument; one end of the swinging arm is movably connected with the endoscope fixing part, and the other end of the swinging arm is movably connected with the instrument lifting part; and the distal end of the traction part is connected with the instrument lifting part. The technical schemeprovides endoscopic surgeons a method for controlling more instruments to be used in a matching way by utilizing the traditional endoscope, meets requirements on multiple-instruments matching operation of the surgeons to a certain extent, achieves certain effects of reducing labor intensity of the complex and time-consuming surgeries encountered currently, such as ESD (Endoscopic Submucosal Dissection) and the like, greatly shortening surgery time and improving safety and operability, facilitate popularization of some complex and time-consuming surgeries to primary hospitals and plays the role of relieving the conditions of poor access to and high cost of medical treatment at present to a certain extent.

A cap (10) for a medical device includes a base member (11). The base member (11) is attached to a distal portion (2a) of an insertion part (2) of a medical device (1) having an endoscope (4). On the base member (11), two linking members (13) are swingably supported by shaft members (12). On distal ends of the linking members (13), a blade (15) is rotatably supported by coupling members (14). The blade (15) has a treatment hole (15a). A treatment part (3) that is inserted through the medical device (1) has a treatment distal portion (33). The treatment distal portion (33) is inserted through the treatment hole (15a). In an endoscopic submucosal dissection, the treatment distal portion (33) makes an incision between a submucosa (101) and mucous membrane (102). The blade (15) pushes up the mucous membrane (102) that is dissected from the submucosa (101), thereby enabling the treatment part (3) to be slipped under the mucous membrane (102).