48 results about "Tissue defect" patented technology

The invention discloses bi-crosslinking self-reinforced hydrogel based on endogenous glucose in-situ initiation as well as a preparation method and application of the bi-crosslinking self-reinforced hydrogel, and relates to the technical field of biomedical materials. The double-crosslinking self-enhanced hydrogel is prepared from the following components in concentration: 1 to 3 weight percent of hyaluronic acid-tyramine, 0.8 to 1.2 weight percent of sodium alginate, 1 to 100 mmol / L of calcium carbonate, 0.0001 to 10 U / mL of horse radish peroxidase, 20 to 40 U / mL of glucose oxidase and the balance of ultrapure water. The invention also discloses an application of the double-crosslinking self-reinforced hydrogel in preparation of a filling and repairing product for soft tissue defects. The hydrogel disclosed by the invention can be filled in a tissue defect part in an injection manner, glucose in body fluid is utilized to initiate crosslinking in situ to form the hydrogel with excellent mechanical properties and long-term stability, and meanwhile, the hydrogel is good in biocompatibility and relatively high in application value.

The present disclosure relates generally to devices and methods for treating a tissue defect, for example, by suturing. In some embodiments, a suturing device may include an elongate member having a working channel, a suture channel, and a suture arm extending from the elongate member. The suturing device may further include a needle passer located within the working channel, the needle passer operable to deliver a needle between the elongate member and a distal end of the suture arm for suturing a target tissue, and a suture extending through the suture channel, wherein the suture is coupled to the needle. The suturing device may further include a plurality of imaging devices, wherein a first imaging device is positioned along a distal face of the elongate member, and wherein a second imaging device is positioned along the suture arm.

The invention discloses an instant plugging agent as well as a preparation method and application thereof, and belongs to the technical field of biological materials. The instant plugging agent comprises a solution A and a solution B, wherein the solution A is an organic solution containing lipoic acid; the solution B is an aqueous solution containing metal ions. The preparation method comprises the following steps: dissolving lipoic acid in an organic solvent to prepare a solution A; dissolving salt of metal ions in water to prepare a solution B; the application refers to the application in preparation of products for stopping bleeding of human bodies or animal bodies and / or sealing tissue defects. The plugging agent has the characteristic of instant curing, and can tolerate bursting pressure exceeding 450 mm Hg; the device is not only suitable for general wound errhysis, but also can effectively deal with acute hemorrhage and emergency plugging of tissue defects in high-pressure and high-flow-rate states.

A medical device for approximating and securing tissue without requiring knots includes a lock-head, a strap section, distal protuberance, and a leader section. The device also includes a transition section between the leader and the strap section and a stiffening section proximal to the protuberance. The leader section is used to draw the strap section into the body through small apertures in tissue and the transition section provides a gradual transition in stiffness and size between the leader and the strap section.

The application relates to the field of medical devices, in particular to a closure device with positioning and guiding puncture functions, which comprises a delivery catheter, an implant for closing a tissue defect, and a puncture mechanism and a positioning member arranged in the delivery catheter, the puncture mechanism can puncture the tissue to be closed back and forth, the positioning member comprises a connecting member and a positioning support arranged at the distal end of the connecting member, and the positioning support can provide a supporting force for the puncture mechanism when puncturing the tissue to be closed back and forth; in the application, the positioning support can provide bidirectional support for the puncture mechanism when puncturing the tissue back and forth, the puncture precision is improved, the tissue can be prevented from being damaged, and the application has good clinical significance.

The application discloses application of tumor-derived acellular extracellular matrix in preparation of a drug for promoting angiogenesis and tissue regeneration. The application proposes a strategy for regulating tissue regeneration based on a tumor-derived acellular extracellular matrix microenvironment, combines the high similarity between a tumor microenvironment and a regeneration microenvironment such as angiogenesis, and constructs a novel angiogenesis-promoting biomaterial, so that high-efficiency regeneration is realized in various tissue defects. In addition, the characteristics of rapid proliferation of tumor tissues break through the production capacity bottleneck of a raw material source of a traditional acellular extracellular matrix, and provide sustainable biological raw materials for large-scale production. The application successfully solves the problem that a specific tissue-derived acellular extracellular matrix is difficult to regenerate in a complex damage microenvironment.

A tissue repair device, system, and method for grasping tissue, such as to repair the tissue (e.g., a defect in tissue), by anchoring a tissue-penetrating arm along a first location along the tissue, moving the anchored tissue-penetrating arm to a second location along the tissue, and grasping tissue at the second location with a tissue-grasping arm. The tissue-penetrating arm remains in a substantially axial straight configuration to facilitate tissue penetration. The tissue-grasping arm is movable towards and away from the tissue-penetrating arm to grasp tissue and hold the grasped tissue between the tissue-grasping arm and the tissue-penetrating arm. The tissue repair device may be left in place holding the tissue in the grasped configuration.

The present application relates to a kind of tissue defect plugging device and tissue defect plugging device.Tissue defect plugging device includes plugging device body, plugging device body is memory material.When plugging device body is in natural relaxed state, all clamping ring is in the same plane, or, adjacent two clamping ring is provided with gap in the direction of straight line perpendicular to its plane, can produce original shape restoring torque, so that the first atrial septum and the second atrial septum produce mutual close tendency, and then make the first atrial septum and the second atrial septum mutually close and close, finally reach the purpose of closing foramen ovale, plugging effect is better, while operation is relatively simple.In addition, because the caliber of clamping ring is different, so as to cancel the flow blocking film, simple structure, also obtain the effect of plugging foramen ovale;In addition, using the above structure design form, the metal material implanted in body is less, can avoid the complication of thrombosis, i.e. not easy to cause adverse reaction.

This invention discloses a microgel-assembled bilayer scaffold for integrated osteochondral repair and its preparation method. The preparation method includes the following steps: (1) synthesizing gelatin modified with carbon-carbon double bonds and dopamine; (2) preparing modified gelatin composite microgels loaded with bioactive glass and chondroitin sulfate respectively; (3) preparing hyaluronic acid modified with carbon-carbon double bonds and phenylboronic acid; (4) suspending the modified gelatin composite microgels loaded with bioactive glass and the modified gelatin composite microgels loaded with chondroitin sulfate in modified hyaluronic acid solutions respectively, and loading them into two different syringes; (5) injecting the two microgel suspensions sequentially into a mold, and constructing the microgel-assembled bilayer scaffold in situ under ultraviolet light. The scaffold of this invention has an open porous structure and good cell compatibility, which can promote the bidirectional differentiation of bone marrow mesenchymal stem cells into chondrogenic and osteogenic cells, and can be used for integrated regeneration and repair of osteochondral tissue defects.

This application relates to the field of medical devices, and more particularly to a tissue puncture closure device with a control device, including a delivery system and an implant for closing tissue defects. The control device includes a connection control mechanism and a guide control mechanism. The implant includes a blocking member and a connector connected to the blocking member. The delivery system includes a puncture member and a pusher member for pushing the blocking member. The connection control mechanism includes a first connecting structure disposed on the blocking member and a second connecting structure disposed on the pusher member and detachably connected to the first connecting structure. The blocking member and the pusher member are slidably sleeved within the puncture member. The guide control mechanism includes a first guide structure disposed on the distal portion of the puncture member and a second guide structure disposed on the blocking member and / or the pusher member. The connection control mechanism and the guide control mechanism respectively restrict the axial movement and circumferential rotation of the blocking member relative to the puncture member, ensuring that the blocking member does not prematurely detach from the puncture member or rotate arbitrarily.

Local tissue defects, liquefaction, infection, and necrosis of skin resulted from various reasons may lead to skin damage and vascular regeneration disorders. Wound hypoperfusion, metabolic disorders, and delayed epithelial cell formation disrupt the process of normal wound healing, thereby leading to the formation of chronic ulcer. To solve the aforementioned problems, a use of polymer dot is provided. The polymer dot may be used for manufacture of a component for the treatment of skin to a subject in need, in order to restore skin damage of the subject, minimize a scar on the damaged skin of the subject, and enhance recovery of the skin of the subject after cosmetic or dermatologic surgery. The polymer dot includes a carbon dot.

The application relates to the field of medical devices, in particular to a closed system with a supporting function, which comprises a first delivery tube, an implant for closing a tissue defect, and a puncture assembly and a second delivery tube arranged in the first delivery tube, the puncture assembly can reciprocally puncture the tissue to be closed, the second delivery tube is provided with a first connecting rod and a supporting device arranged at the distal end of the first connecting rod, the supporting device has a preset shape, wherein, when the supporting device restores to the preset shape, the supporting device forms a first supporting area and a second supporting area, and the first supporting area and the second supporting area respectively provide support for the puncture assembly when reciprocally puncturing the tissue to be closed; in the application, the supporting device is simple in structure, large in supporting area and easy to recycle.

This invention provides a calcium phosphate-polycaprolactone composite scaffold, its preparation method, and its applications. The raw materials for preparing the calcium phosphate-polycaprolactone composite include polycaprolactone, β-tricalcium phosphate, and hydroxyapatite. The resulting composite scaffold possesses functions of promoting immunity and regulating bone regeneration. The preparation method of this invention involves first forming a hydroxyapatite / polycaprolactone composite film, which is then broken down and recombined with β-tricalcium phosphate to form a composite solution. The resulting 3D-printed composite scaffold not only possesses good mechanical strength and biocompatibility but also induces stem cell proliferation and osteogenic differentiation, and induces macrophage regeneration and polarization. It can be used to regulate immune cell responses, induce a bone immune microenvironment conducive to bone formation, thereby enhancing bone regeneration, and can be used for the repair and regeneration of tissue defects.

The present application relates to the field of medical materials, in particular to a preparation method of high-performance medical tantalum coating. A thin-size-low-diffusion tantalum coating is prepared on the surface of a porous titanium alloy substrate by a chemical vapor deposition method through a halide reaction of hydrogen reduction of metallic tantalum; there is an alloy element interdiffusion zone between the tantalum coating and the porous titanium alloy substrate, and the thickness of the interdiffusion zone is less than the thickness of the tantalum coating. The present application obtains a high-performance thin-size tantalum coating with high purity, small grain size and controllable transition layer suitable for the porous titanium alloy substrate, has higher preparation efficiency and lower cost, realizes high bonding strength of the coating and simultaneous improvement of the strength and plasticity of the porous titanium alloy, avoids dissolution of toxic metal ions such as Al and V, and improves biocompatibility and osteogenic performance. The new tantalum coating porous titanium alloy implant device has obvious advantages of higher mechanical, chemical and biological safety and lower cost, and is suitable for the fields of orthopedics, dental implants and tissue defect fillers.

An injectable bifunctional hydrogel has antibacterial activity. The bifunctional hydrogel is a hydrogel prepared by dissolving nucleoside analogues in a solvent. The nucleoside analog has a structure of formula I. It can be a candidate drug for the local injection treatment of periodontal disease, and it also has potential application prospects in the minimally invasive treatment of craniofacial bone tissue defects.

Compositions comprising a condensed mesenchymal cell body and a hydrogel are provided. The compositions may further include drugs or growth factors. The condensed mesenchymal cell body may include a connective tissue cell, or even a progenitor cell capable of producing connective tissue extracellular matrices such collagen and glycosaminoglycan. Also provided are methods of treating connective tissue defects, cartilage injury, and cartilage degradation.

A medical device for approximating and securing tissue without the need for knots includes a locking head, a strap portion, a distal ridge, and a leader portion. The device also includes a transition portion between the leader and strap portion and a reinforcing portion proximal to the ridge. The leader portion is used to pull the strap portion through a small opening in the tissue and into the body, and the transition portion provides a gradual transition in stiffness and size between the leader and strap portion. A tensioner and cutter are provided, as well as a threading tool configured to be slidably removed from the lumens of the tensioner and cutter. A blade is provided within the lumens of the tensioner and cutter for cutting off excess leader and / or strap when the procedure is complete.

A medical device for approximating and securing tissue without requiring knots includes a lock-head, a strap section, distal protuberance, and a leader section. The device also includes a transition section between the leader and the strap section and a stiffening section proximal to the protuberance. The leader section is used to draw the strap section into the body through small apertures in tissue and the transition section provides a gradual transition in stiffness and size between the leader and the strap section. Tensioner and cutter and a threading tool configured to be slidably removed from a lumen of the tensioner and cutter is provided. A blade within the lumen of the tensioner and cutter is provided to cut excess leader and / or strap when the procedure is completed.

The invention relates to a bionic bone scaffold customized body and a preparation method and application thereof, and belongs to the technical field of biomedical materials. The invention provides a preparation method of a bionic bone scaffold customized body, which comprises the following steps: scanning and recording a cranio-maxillofacial hard tissue defect form, and constructing a digital scaffold model through an algorithm model and / or artificial design based on the recorded data; performing three-dimensional reconstruction on the obtained digital scaffold model to generate bionic bone scaffold customized volume data meeting the personalized requirements of cranio-maxillofacial tissue defects; and converting the obtained customized body data of the bionic bone scaffold into a customized body of the bionic bone scaffold by utilizing a 3D printing technology. Modeling is conducted through real bone defect data, a bionic bone scaffold customized body of the bone defect part is prepared through the 3D printing technology, the outer contour is attached to the bone defect side form, the ideal bone form is reconstructed, the inner contour is a fine substructure of the defect part, and the bionic bone scaffold has a bionic pore structure and biomechanical performance; the method can be used for reconstructing personalized cranio-maxillofacial tissues.

This application provides an endoscopic tissue closure device, including a working part, a transmission part, and a control handle. The working part includes a claw assembly, a flexible fitting wing, a tightening tube, a front end tube, and a traction assembly. The tightening tube and the front end tube are detachably connected to form a movable cavity, and the traction assembly is placed in the movable cavity. At least three elastic claws of the flexible fitting wing and the claw assembly are tightened at the front end of the tightening tube, and the elastic claws surround the outer side of the flexible fitting wing. The transmission part connects the front end tube and the control handle. The traction assembly includes a first traction mechanism and a second traction mechanism. The control handle controls the extension and retraction of the flexible fitting wing and the claw assembly through the two traction mechanisms respectively. After the flexible fitting wing extends, it releases and unfolds, abutting against the outer surface of the wound. After the claw assembly extends, it elastically opens to grasp the edge of the inner wound, and closes under the action of the tightening tube when it retracts. Through the coordinated cooperation of the fitting wing and the claws, precise coverage and all-round grasping of tissue defects are achieved, improving the reliability of closure and simplifying the operation.

Methods, systems, and apparatus, including computer programs encoded on computer storage media, for bioprinting cellular tissue in-situ. One of the systems includes a device body comprising: a first housing adapted to store one or more tissue repair ingredients; and a second housing for a motor adapted to move at least one tissue repair ingredient from the first housing to a tissue printing head; and the tissue printing head comprising: a printing nozzle adapted to receive the at least one tissue repair ingredient from the first housing and deposit the at least one tissue repair ingredient onto one or more locations of a tissue defect; an ingredient guidance device adapted to direct the at least one tissue repair ingredient toward the one or more locations of the tissue defect; and a removable coupling device adapted to couple the tissue printing head onto a region of the patient.

The application provides a microgel bio-ink, a microgel scaffold containing a nerve-vascular network and a preparation method and application thereof, and belongs to the technical field of biological medicine. The microgel bio-ink prepared by the application has a significant self-healing ability when printing, ensures high-precision extrusion molding, has excellent shear thinning ability, and the viscosity is significantly reduced with the increase of the shear rate; the microgel bio-ink keeps a solid structure at a physiological temperature and has temperature-sensitive stability; the self-healing effect is significant, the mechanical stability of the printed body is improved, and the microgel bio-ink has good printing extrusion and forming ability. The application realizes the composite printing of neuron-carrying microspheres and vascular endothelial cells, successfully constructs a microgel scaffold containing a nerve-vascular network, and can be used for simulating the microenvironment interaction mechanism in vivo and providing an integrated solution for complex tissue defect repair.

The application discloses a drug-loaded guided periodontal tissue regeneration membrane and a preparation and application thereof. The drug-loaded guided periodontal tissue regeneration membrane comprises a soluble composite matrix material and nano drugs loaded in the soluble composite matrix material. The application is based on the principle and manufacturing concept of periodontal GTR, conceives to design the interface implant into a structure with gradient change of components and structure, promotes bone growth, prevents bacterial infiltration and growth of gum tissue to the tissue defect area below, makes the characteristics of the membrane more and more tend to be "ideal", satisfies the local functional requirements, improves the multi-aspect performance of the membrane, and realizes more excellent tissue regeneration.

The application discloses modified carrageenan / gelatin double-network structure composite microspheres capable of loading hydrophobic drugs and a preparation method and application thereof. The composite microspheres are formed by crosslinking of acid anhydride esterified carrageenan and gelatin. The acid anhydride esterified carrageenan is formed by esterification reaction of high-concentration carrageenan and acid anhydride, and the substitution degree of the acid anhydride esterified carrageenan is controlled to be 10% to 20%. The substitution degree of the esterification reaction is controlled by controlling process parameters, the impurity content is reduced, the ability of the microspheres to load hydrophobic drugs is endowed, the double-network structure microspheres are prepared by a double-crosslinking technology, drug leakage can be reduced, drug release can be delayed, and the double-network structure microspheres can be applied to the fields of interventional embolization, medical beauty filling, tissue defect repair and drug carriers.

The invention discloses a pharmaceutical composition containing a tumor-derived acellular extracellular matrix and an application of the pharmaceutical composition. The invention provides a strategy for regulating and controlling tissue regeneration based on a tumor-derived acellular extracellular matrix microenvironment, a novel angiogenesis promoting biological material is constructed by combining the high similarity of a tumor microenvironment and a regeneration microenvironment such as angiogenesis, and high-efficiency regeneration is realized in various tissue defects. In addition, due to the characteristic of rapid proliferation of the tumor tissue, the productivity bottleneck of a traditional acellular extracellular matrix raw material source is broken through, and sustainable biological raw materials are provided for large-scale production. The method successfully solves the problem that a specific tissue-derived acellular extracellular matrix is difficult to regenerate in a complex damaged microenvironment.

The invention discloses a dual crosslinking mechanical self-adaptive biological adhesion hydrogel. The mechanical self-adaptive biological adhesion hydrogel is prepared from dopamine modified sodium alginate, bovine serum albumin and multi-arm polyethylene glycol-phthalic dicarboxaldehyde through dual covalent crosslinking. The hydrogel is endowed with the mechanical self-adaptive characteristic through the combined action of dopa and protein. Under the stress action and physiological oxidation environment, protein conformation in the hydrogel is expanded and cooperates with gradual oxidation of dopa, so that stress dissipation and adhesion strength self-enhancement along with time are realized while the material keeps flexibility, and long-term effective sealing of tissues can still be maintained under the condition of dynamic deformation. The hydrogel has the characteristics of active oxygen removal, antibiosis and enzyme response degradability, the whole system is composed of biomacromolecules and medical macromolecules, and the hydrogel has good biocompatibility and in-vivo degradability. And a new technical approach is provided for the sealed repair of airway fistula, gastrointestinal fistula and other tissue defects and the development of implantable bioadhesive materials.

The application provides application of a lentivirus vector overexpressing CYGB in repairing engineering materials. Specifically relates to application of the lentivirus vector overexpressing CYGB in repairing tissue defect engineering materials, and application of adipose-derived stem cells containing the lentivirus vector overexpressing CYGB in repairing tissue defect engineering materials. The lentivirus vector overexpressing CYGB is used to transfect adipose-derived stem cells, and the obtained adipose-derived stem cells containing the lentivirus vector overexpressing CYGB can promote proliferation and adipogenic differentiation of the adipose-derived stem cells, form tissue engineering fat, and be filled into a tissue defect site as an implant material to repair the tissue defect.

To provide an improved strap having one-way locking (knotless) characteristics suitable for gathering tissue, such as closing a hernia defect.SOLUTION: The device 1 includes a locking head 5 at a proximal end, a strap 3 extending from the locking head 5, and a leader 7 extending from the strap 3. The leader 7 may have a loop 9 or other protuberance at its distal end to facilitate grasping during a surgical procedure, or alternatively, the leader 7 may have a distal end without a grasping feature in some embodiments, as it may be easily grasped by some surgical tools even without an engagement feature at the end. In general, leader 7 may be grasped anywhere along its length by any common tool used to grasp sutures.SELECTED DRAWING: Figure 1

The invention provides a material omics strategy combining bioinformatics and mathematical modeling. The material omics strategy is used for regulating extracellular matrix-based hydrogel. The prepared improved material can be particularly used for treating tissue defect diseases such as tendon defects. The hydrogel can be directly used as a transplantation material and other treatment means, and the provided hydrogel can also be indirectly applied to preparation of differentiated stem cells, cell-derived extracellular matrix products or extracellular vesicles. In addition, the invention also provides a preparation method of the hydrogel, the transplantation material, the differentiated stem cell, the extracellular matrix and the vesicle product, and a method for repairing tissue defects by using the materials.

A tissue recruiting device for treating and closing a defect and methods of using the same. The tissue recruiting device includes a tissue recruiting assembly with two grasping devices and a shroud. An actuation assembly couples control actuators to the grasping devices via actuation elements. The grasping devices may be maneuvered to grasp tissue from different locations by actuation of the control actuators. The grasping devices may be retracted into a shroud to substantially close the defect. The grasping devices and the shroud may be decoupled from the remainder of the tissue recruiting assembly to maintain closure of the defect.