38results about "Skin implants" patented technology

A packaging system (10b) is provided that includes a packaging body defining a cavity (14b) and a seal (18b) configured to be joined to the packaging body to fluidly seal the cavity. The packaging system may also include at least one tissue cradle (16b) configured to be disposed within the cavity. A cavity having a single size may be configured to accommodate differently sized tissue cradles. In addition to the cavity the packaging system may include one or more additional reservoirs configured for holding a volume of liquid. Such packaging systems may be used in the storage of wet-preserved or dry-preserved human or animal tissue. Also provided are a packaged tissue specimen and a method for packaging tissue.

The invention discloses a multi-scale artificial dermal scaffold and a preparation method thereof, and belongs to the technical field of tissue engineering and biomedical materials. The artificial dermal scaffold is of a three-dimensional porous structure formed by microfilaments of a first frame and a second frame, the microfilaments of the second frame are distributed in pores of the first frame, disordered microfilaments which do not affect the penetrability of the macropores are arranged in the macropores in the top surface of the first frame, and longitudinally aligned microfilaments are arranged in the micropores in the section of the first frame. Through the specific structure, the adhesion, proliferation and migration effects of cells can be remarkably improved, and rapid vascularization of artificial dermis is facilitated. In addition, the preparation process of the artificial dermal scaffold is simple and easy to operate, can be used for batch preparation, and has a good application prospect.

The present invention relates to a dental / medical device that comprises poly(dioxanone) (PDO or PDS), preferably has an absorbent synthetic film exhibiting a color from white to grey, and is applied in the medical and dental fields. The dental / medical device may have stem cells and graphene used for inducing tissue reconstruction and / or inducing tissue regeneration of bone defects and other connective tissues (such as gingiva, skin, cartilage, cornea, etc.). Further, the present invention relates to the use of the device for the related applications described above and a method for manufacturing the device.

Systems and methods are disclosed that include determining medical treatment parameters based on a desired appearance. The system includes a camera, a display, and a processing system. The system may also include a projection device or system. The camera may capture one or more digital images of a body part of a subject. The display may display one of the digital images captured by the camera and allow inputs through a touchscreen user interface that alter a characteristic of the body part of the subject based on a desired appearance of the subject. The processing system may analyze the inputs and the desired appearance of the subject to calculate a medical treatment designed to achieve or to correspond to the desired appearance in the subject.

A universal biological prosthesis of acellular dermal matrix (ADM) intended for use in body reconstruction processes and method of manufacture. A universal biological prosthesis of acellular dermal matrix (ADM) intended for use in body reconstruction processes, comprising: a first layer of ADM of biological origin arranged inferiorly to delimit a cavity with a lower edge; a filling material disposed in the cavity surrounded by the first layer of ADM consisting of a ground ADM having the consistency of a fibrous paste; and a second layer of ADM of biological origin arranged on the upper part covering the filling material and whose upper edge rests peripherally on the lower edge of the first layer of ADM, thus defining a rim;where the first layer of ADM and the second layer of ADM are joined by an eyebrow overlap along the upper edge of the first layer of ADM with the lower edge of the peripheral rim using a biocompatible adhesive, or by absorbable suture; where the first layer of ADM, the second layer of ADM and the ADM filling material are not immunogenic; and where the ADM comprises collagen fibers, fibronectin, elastin, laminin, glycosaminoglycans and hyaluronic acid. Method for its manufacture.

The specification relates to a method of manufacturing a diabetic foot patient-specific skin regeneration sheet, and a diabetic foot patient-specific skin regeneration sheet. The method includes extracting autologous adipose tissue, removing fibers in the autologous adipose tissue, crushing the autologous adipose tissue, and acquiring an adipose tissue extract by filtrating the crushed autologous adipose tissue.

The present invention discloses a novel method for developing Human HLA-a / b / c triple knockout hair follicle stem cells (HFSCs) intended for promoting HFSCS transplantation. The method involves precise genetic modification techniques to knockout HLA-a / b / c genes, facilitating enhanced compatibility and effectiveness in hair follicles transplantation. The inventive approach aims to address challenges (donor dependent and large scar) in hair implantation therapy by leveraging advanced gene-editing and stem cell technologies.

A structure of aligned (e.g., radially and / or polygonally aligned) fibers, and systems and methods for producing and using the same. One or more structures provided may be created using an apparatus that includes one or more first electrodes that define an area and / or partially circumscribe an area. For example, a single first electrode may enclose the area, or a plurality of first electrode(s) may be positioned on at least a portion of the perimeter of the area. A second electrode is positioned within the area. Electrodes with rounded (e.g., convex) surfaces may be arranged in an array, and a fibrous structure created using such electrodes may include an array of wells at positions corresponding to the positions of the electrodes.

Provided is a method for producing a skin organoid, the method comprising: a step for performing a first culture of a primary skin cell in a first medium with at least one support among an extracellular matrix (ECM) and polyethylene glycol (PEG) to form a first skin organoid; and a step for performing a second culture of the first skin organoid in a second medium. In addition, the present disclosure provides: a skin organoid cultured by the method described above, the skin organoid having a round, spherical, three-dimensional shape and comprising a center portion, which is densely packed with cells, a stratum corneum formed on the outside of the center portion, and a hair root, wherein the cells can move from the center portion to the stratum corneum; and a method for evaluating drug toxicity by using same.

The present invention relates to a bioabsorbable implantable device (100) comprising a base structure including at least one base layer (10), said base structure comprising: an assembly A (1A) including a layer of a plurality of elongated elements A1 (1A1) and a layer of a plurality of elongated elements A2 (1A2) oriented in a longitudinal direction LA1; and an assembly B (1B) including a layer of a plurality of elongated elements B1 (1B1) and a layer of a plurality of elongated elements B2 (1B2) oriented in a longitudinal direction LB1, said assembly B (1B) being at least partially disposed on said assembly A (1A), said direction LA1 intersecting said direction LB1, said base structure comprising a plurality of base layers disposed at least partially overlapping each other.

The present invention relates to a curved needle for injecting dermal fillers into the lip and perioral area.

To provide an implantable inflatable device.SOLUTION: An implantable inflatable device (100) includes a fluid reservoir (110) defining a cavity, an inflatable member (150), a pump assembly (130) configured to transfer fluid from the fluid reservoir to the inflatable member, and a programmable control module. The programmable control module is configured to activate the pump assembly to transfer fluid from the fluid reservoir to the inflatable member.SELECTED DRAWING: Figure 1

A structure of aligned (e.g., radially and / or polygonally aligned) fibers, and systems and methods for producing and using the same. One or more structures provided may be created using an apparatus that includes one or more first electrodes that define an area and / or partially circumscribe an area. For example, a single first electrode may enclose the area, or a plurality of first electrode(s) may be positioned on at least a portion of the perimeter of the area. A second electrode is positioned within the area. Electrodes with rounded (e.g., convex) surfaces may be arranged in an array, and a fibrous structure created using such electrodes may include an array of wells at positions corresponding to the positions of the electrodes.

The present invention relates to an artificial organ production system that utilizes a big data infrastructure. The artificial organ production system of the present invention includes an input unit that accepts user requirements for the artificial organ to be produced as input values, a database unit that stores data necessary for artificial organ production, a control unit that produces the artificial organ by inputting the input values ​​into an artificial organ production algorithm learned based on the database unit, and a bioprinter that produces the artificial organ under the control of the control unit.

A hair implant suitable for subcutaneous implantation is provided having an anchor comprising an anchor body, and at least one collagen receiving structure selected from the group consisting of at least one tunnel disposed through the anchor body or an external surface feature of the anchor body. The anchor further comprises at least one hair strand projecting from a distal end of the anchor body and alternatively wherein the at least one hair strand includes a bend, wherein the at least one collagen receiving structure, or the external surface feature, is configured to support collagen ligature growth after subcutaneous implantation of the hair implant so as to anchor the hair implant in the recipient. The hair implant includes a two-part construction having a base module formed of the anchor body and at least one hair stem configured for coupling with a long hair strand. Another hair implant alternative includes a hair strand having a first end that is passed through the skin, underneath and the up through the skin at another location to result in the hair strand having two portions projecting from the skin surface.

A device and method for implanting a piece of hair into the scalp of a patient, in which the cross-sectional shape of a rod resting on an implantation needle is configured relative to the needle to communicate a vacuum in a chamber in front of the needle to the interior of the needle, thereby facilitating loading of the piece of hair into the device by direct needle suction of the piece of hair.

The application discloses a kind of tactile sensor, the detection method of touch event, sensing device and robot, belong to sensor design field.The tactile sensor includes: sensing unit (21), elastomer support shell (22) and base (23);Sensing unit (21) is set in the inner cavity enclosed by elastomer support shell (22) and base (23);Sensing unit (21) includes at least two light sources (211), photoelectric detector (212) and reflector (213), photoelectric detector (212) is set on base (23), at least two light sources (211) are set around photoelectric detector (212) on base (23), and reflector is set on the top of the inner cavity of elastomer support shell (22).The application is by using the combination mode of multiple light sources and a photoelectric detector, reduces the use quantity of photoelectric detector, so that the volume of tactile sensor is reduced.

The present invention relates to an implant comprising at least one three-dimensional porous structural element of at least one synthetic polymer, wherein the at least one porous structural element is irreversibly attached to an implant element by means of at least one adhesive polymer, methods for preparing the same, and uses thereof.

This invention belongs to the field of tissue engineering and regenerative medicine technology, specifically a multi-layered biomimetic skin structure and its synchronous bio-3D printing preparation method and system, comprising a sequentially combined epidermal layer and dermal layer. This invention highly mimics natural skin through a multi-layered structure. A micropillar array in the dermal layer provides a strong mechanical anchor between the epidermis and dermis, while embedded PLGA microspheres can sustainably release VEGF and EGF for 3-4 weeks, continuously promoting repair. Integrated vascular network channels and nerve guidance structures address the challenges of nutrient delivery and the lack of neural perception function, respectively, filling the functional gaps in traditional biomimetic skin. The synchronous bio-3D printing process enables integrated fabrication of the multi-layered structure. Combined with a four-channel printhead and a multi-physics coupling module, along with a visual positioning and pressure feedback system, printing accuracy and stability are ensured, preventing filament breakage or ink overflow. An intelligent cultivation system simulates the physiological environment, further enhancing skin maturity. This invention is applicable to the repair of skin defects such as burns and chronic ulcers.

There is disclosed a packaged allograft implant configured for implantation in a human recipient. In an embodiment, the packaged allograft implant includes an acellular dermal matrix sheet having a top surface and a bottom surface in opposition to one another, a perimeter surrounding the top surface and the bottom surface, and a thickness extending between the top surface and the bottom surface. The packaged allograft implant further includes a mesh pattern extending across at least a portion of the top surface and the bottom surface of the acellular dermal matrix sheet, the mesh pattern providing through-holes extending between the top surface and the bottom surface of the acellular dermal matrix sheet, and the mesh pattern having a plurality of mesh lines extending in a first direction and a second direction. The first direction and the second direction are orthogonal to one another so as to allow a given amount of stretch in each of the first direction and the second direction. Other embodiments are also disclosed.

The harvesting of hair for a hair transplant procedure with immediate placement of the hair grafts to the balding area. The harvesting tool may be robotically controlled. The tool utilizes vacuum to facilitate complete excision. The graft that is excised is sucked though tubing and almost instantaneously delivered to an implanter held by the surgeon (Duplex Implanter) or by a robot. This graft on Demand system is controlled by the surgeon through a series of commands to the handpiece of the implanter for one, two, three or more hair grafts. In another embodiment, a computer maps out the location of every graft within the surgical field of view, in part or in whole, and selects those follicles, minimizing the spacing left remaining after each excision while obtaining the number of grafts targeted by the surgeon.

A packaging system (10b) is provided that includes a packaging body defining a cavity (14b) and a seal (18b) configured to be joined to the packaging body to fluidly seal the cavity. The packaging system can also include at least one tissue cradle (16b) configured to be disposed within the cavity. A cavity having a single size can be configured to accommodate differently sized tissue cradles. In addition to the cavity, the packaging system can include one or more additional reservoirs configured to hold a constant volume of liquid. Such packaging systems can be used for storing wet- or dry-stored human or animal tissue. Packaged tissue specimens and methods for packaging tissue are also provided.

A compliant scaffold incorporates a plurality of elongated apertures that form a geometric pattern enabling biaxial expansion or contraction. An elongated aperture has a pair of nodes located on opposing sides of the aperture and between a pair of antinodes located on the extended and opposing ends of the elongated aperture. A geometric pattern may have various geometric shapes, or tiles, between the plurality of apertures. The geometric tiles have a bounded perimeter formed by the plurality of elongated apertures. A substantial portion of the elongated apertures may be configured with the antinodes proximal to one of said pair of nodes of a separate elongated aperture; wherein the antinodes are closer to one of the pair of nodes than to any other antinode. This unique arrangement of the elongated apertures may be formed in biological material in vivo or ex vivo.

The present invention relates to a dental / medical device consisting of an absorbable synthetic membrane, preferably white to gray in color, comprising poly(dioxanone) and optionally graphene and stem cells, to be used in guided tissue reconstruction and / or regeneration of bone defects and other connective tissues (gum, skin, cartilage or cornea, for example). Furthermore, the present invention relates to the use of said device for the above-related applications and to the process of preparing said device.

To provide a mesh assembly having improved fixing force and pulling force for biological tissues and having an excellent effect of coming in close contact with skin tissues and maintaining and fixing the skin tissues.SOLUTION: There may be provided a mesh assembly having improved fixing force and pulling force for biological tissues and having an excellent effect of coming in close contact with skin tissues and maintaining and fixing the skin tissues. The mesh assembly is inserted in skin tissues of a human body, and may include a mesh member in which a plurality of linear members crossing each other are formed in a cylindrical shape.SELECTED DRAWING: Figure 2

The present disclosure provides an engineered dermis comprising one or more layers of human dermal fibroblast compositions as well as scaffolds and methods of the same. The disclosure also provides compositions comprising one or more interwoven extracellular matrices, wherein the interwoven extracellular matrices have been decellularized as well as scaffolds and methods of the same.

The present invention discloses a novel method for developing Human HLA-a / b / c triple knockout hair follicle stem cells (HFSCs) intended for promoting HFSCS transplantation. The method involves precise genetic modification techniques to knockout HLA-a / b / c genes, facilitating enhanced compatibility and effectiveness in hair follicles transplantation. The inventive approach aims to address challenges (donor dependent and large scar) in hair implantation therapy by leveraging advanced gene-editing and stem cell technologies.

The invention discloses a silica gel electronic skin and a preparation method thereof, the silica gel electronic skin is cured and formed by immersing intelligent fibers into a silica gel prepolymer solution, and the intelligent fibers are elastic fiber membranes with the surfaces modified by functional materials. The elastic fiber membrane can realize high-precision sensor patterning arrangement, so that the problem of insufficient precision when the sensor is directly processed on the silica gel substrate is avoided; the tensile stress applied by the outside can be effectively borne and dispersed, the local stress concentration of the silica gel matrix is reduced, the overall strength and toughness of the material are improved, the interface bonding performance is good, the stress is transmitted through the interface shearing effect in the tensile process, the elongation at break and the tear resistance of the material are further improved, and the service life of the material is prolonged. Four limbs and arms can be better wrapped, and the artificial skin can be applied to robot skin, artificial limbs, wearable equipment and skin transplantation.