115results about "Skin implants" patented technology

The utility model discloses a skin extrusion / ink-jet composite printing device, which belongs to the technical field of biological tissue printing and comprises a computer, a three-dimensional motion system, an ink box, an ink-jet printing head, an extrusion printing head, a temperature control substrate, an air pump and a pressure controller. The ink box is installed on the ink-jet printing head, and the ink-jet printing head and the extrusion printing head are installed on the three-dimensional motion system. The pressure controller is mounted on the air pump; the pressure controller is in air connection with the ink box and the extrusion printing head; the computer is electrically connected with the three-dimensional motion system, the ink-jet printing head and the pressure controller. The computer is used for controlling the three-dimensional motion system to move and further used for controlling ink jet of the ink jet printing head and controlling the pressure controller to output the air pressure value. The personalized skin printing device provided by the utility model is low in manufacturing cost and high in efficiency.

A packaging system (10b) is provided that includes a packaging body defining a cavity (14b) and a seal (18b) configured to be joined to the packaging body to fluidly seal the cavity. The packaging system may also include at least one tissue cradle (16b) configured to be disposed within the cavity. A cavity having a single size may be configured to accommodate differently sized tissue cradles. In addition to the cavity the packaging system may include one or more additional reservoirs configured for holding a volume of liquid. Such packaging systems may be used in the storage of wet-preserved or dry-preserved human or animal tissue. Also provided are a packaged tissue specimen and a method for packaging tissue.

The invention discloses a multi-scale artificial dermal scaffold and a preparation method thereof, and belongs to the technical field of tissue engineering and biomedical materials. The artificial dermal scaffold is of a three-dimensional porous structure formed by microfilaments of a first frame and a second frame, the microfilaments of the second frame are distributed in pores of the first frame, disordered microfilaments which do not affect the penetrability of the macropores are arranged in the macropores in the top surface of the first frame, and longitudinally aligned microfilaments are arranged in the micropores in the section of the first frame. Through the specific structure, the adhesion, proliferation and migration effects of cells can be remarkably improved, and rapid vascularization of artificial dermis is facilitated. In addition, the preparation process of the artificial dermal scaffold is simple and easy to operate, can be used for batch preparation, and has a good application prospect.

The present invention relates to a dental / medical device that comprises poly(dioxanone) (PDO or PDS), preferably has an absorbent synthetic film exhibiting a color from white to grey, and is applied in the medical and dental fields. The dental / medical device may have stem cells and graphene used for inducing tissue reconstruction and / or inducing tissue regeneration of bone defects and other connective tissues (such as gingiva, skin, cartilage, cornea, etc.). Further, the present invention relates to the use of the device for the related applications described above and a method for manufacturing the device.

Systems and methods are disclosed that include determining medical treatment parameters based on a desired appearance. The system includes a camera, a display, and a processing system. The system may also include a projection device or system. The camera may capture one or more digital images of a body part of a subject. The display may display one of the digital images captured by the camera and allow inputs through a touchscreen user interface that alter a characteristic of the body part of the subject based on a desired appearance of the subject. The processing system may analyze the inputs and the desired appearance of the subject to calculate a medical treatment designed to achieve or to correspond to the desired appearance in the subject.

The present invention relates to a bioresorbable implantable device comprising a base structure comprising at least one base layer (10) comprising: • - an assembly A (1A) comprising a layer of a plurality of elongate elements A1 (1A1) which are oriented in a longitudinal direction LA1, and a layer of a plurality of elongate elements A2 (1A2); an assembly B (1B) comprising a layer of a plurality of elongate elements B1 (1B1) which are oriented in a longitudinal direction LB1, and a layer of a plurality of elongate elements B2 (1B2); • - the assembly B (1B) is placed at least partially on top of the assembly A (1A); • - the direction LA1 intersects the direction LB1; and • - the base structure comprises a plurality of base layers placed at least partially one on top of the other.

The harvesting of hair for a hair transplant procedure with immediate placement of the hair grafts to the balding area, employs a hollow drill connected to a suction with an imaging system (containing one or more cameras) which permits alignment of the center of the cutting edge of the needle on or slightly offset from the axis of the hair within the follicular unit to be removed. This harvesting tool may be robotically controlled. As each follicular unit may have more than one hair, the surgeon controls the number of hairs in each graft he wishes to remove, excising the graft one at a time. A special FUE tool is used that excises the entire follicular unit with minimal residual attachments. The tool utilizes vacuum to facilitate complete excision. The graft that is excised is sucked though tubing and almost instantaneously delivered to an implanter held by the surgeon (Duplex Implanter) or by a robot. This graft on Demand system is controlled by the surgeon through a series of commands to the handpiece of the implanter for one, two, three or more hair grafts. The excision needle (punch) is placed to remove a hair graft with the chosen number of hairs, taken from an area which has been previously mapped out. When properly aligned, a follicular unit is removed without damaging critical anatomical portions of the follicles and it is delivered to the implanter at the command of the surgeon. In one embodiment, a movable x / y / z stabilizing gantry is employed to position the hollow needle in each instance which can be manually controlled by the surgeon, or robotically controlled with one or more robots. In another embodiment, a computer maps out the location of every graft within the surgical field of view, in part or in whole, and selects those follicles, minimizing the spacing left remaining after each excision while obtaining the number of grafts targeted by the surgeon. In still another embodiment, one or more robotic arms, controlled automatically by a controller or manually by a surgeon, operate graft excision instruments to facilitate speed and accuracy of the excision process.

Provided herewith is a needle for delivering dermal filler thread to a wrinkle in a patient. The needle can also be used to deliver the thread to a patient for the purposes of facial contouring. The needle comprises a coupler for attaching the thread to the needle and also a trocar to ease delivery through the skin.

The specification relates to a method of manufacturing a diabetic foot patient-specific skin regeneration sheet, and a diabetic foot patient-specific skin regeneration sheet.

A universal biological prosthesis of acellular dermal matrix (ADM) intended for use in body reconstruction processes and method of manufacture. A universal biological prosthesis of acellular dermal matrix (ADM) intended for use in body reconstruction processes, comprising: a first layer of ADM of biological origin arranged inferiorly to delimit a cavity with a lower edge; a filling material disposed in the cavity surrounded by the first layer of ADM consisting of a ground ADM having the consistency of a fibrous paste; and a second layer of ADM of biological origin arranged on the upper part covering the filling material and whose upper edge rests peripherally on the lower edge of the first layer of ADM, thus defining a rim;where the first layer of ADM and the second layer of ADM are joined by an eyebrow overlap along the upper edge of the first layer of ADM with the lower edge of the peripheral rim using a biocompatible adhesive, or by absorbable suture; where the first layer of ADM, the second layer of ADM and the ADM filling material are not immunogenic; and where the ADM comprises collagen fibers, fibronectin, elastin, laminin, glycosaminoglycans and hyaluronic acid. Method for its manufacture.

The present invention relates to the technical field of burn patches, and particularly to a burn patch for treating skin wounds and a preparation method thereof. The method includes: dissolving the active ingredients and the collagen into a solvent using a stirrer to output a mixed solution; bonding the silica gel with the nylon textile fabric to output a film patch; coating the mixed solution on one side of the nylon textile fabric of the film patch; drying the film patch coated with the mixed solution using a hot air circulation oven; cutting the dried film patch using a cutting machine; punching holes on the silica gel side of the cut film patch to output a burn patch; determining the preparation stability of the burn patch based on the variance of the concentration of the mixed solution; if the preparation stability does not meet the requirements, adjusting the rotation speed of the stirring motor of the stirrer; if the forming effectiveness does not meet the requirements, adjusting the tool feed of the cutting machine. The present invention improves the preparation stability of the burn patch.

A hair implant having an anchor comprising an anchor body, and at least one collagen receiving structure selected from the group of at least one tunnel through the anchor body or an anchor body external surface feature. The anchor includes at least one hair strand projecting from an anchor body distal end and may include a bend, wherein the at least one collagen receiving structure, or the external surface feature, support collagen ligature growth after hair implant implantation for anchoring in the recipient. The hair implant includes a two-part construction having a base module formed of the anchor body and at least one hair stem for coupling with a long hair strand. Another alternative includes a hair strand first end that is passed through the skin, underneath and then up through the skin at another location to result in the hair strand having two portions projecting from the skin surface.

To provide an implantable inflatable device.SOLUTION: An implantable inflatable device (100) includes a fluid reservoir (110) defining a cavity, an inflatable member (150), a pump assembly (130) configured to transfer fluid from the fluid reservoir to the inflatable member, and a programmable control module. The programmable control module is configured to activate the pump assembly to transfer fluid from the fluid reservoir to the inflatable member.SELECTED DRAWING: Figure 1

An apparatus includes a flexible container and a port. The container includes a first layer coupled to a second layer to define a storage volume within which a tissue specimen can be contained. The first layer has a first stiffness and the second layer has a second stiffness. An edge of the first layer is spaced apart from an edge of the second layer to define an opening into the storage volume. The edges of the first and second layer form a peelable seal that hermetically seals the storage volume such that the first layer can be peeled away from the second layer to expose the storage volume. The port is coupled to the flexible container and allows fluid communication between the storage volume and an external volume.

The invention provides a method for preparing a skin graft composition comprising (a) obtaining, from a subject requiring a skin layer patch or dressing, a skin sample, (b) placing the skin sample in a container with a sterile medium, (c) separating fibroblasts and keratinocytes from the skin sample to obtain a solution comprising fibroblasts and keratinocytes or reshaping and resizing the skin sample to obtain a solution comprising the reshaped and resized skin sample, and (d) combining the fibroblasts and the keratinocytes with a matrix to thereby form a skin graft composition. The invention also provides a method for providing a skin graft composition to a subject, as well as a method of providing a skin layer patch or dressing, or a skin graft, to a subject in need thereof.

Systems and methods for hair transplantation using a hair transplantation device are provided. The hair transplantation device includes an extraction unit including a coring needle configured to extract at least one hair follicle from a donor site; an implantation unit removably coupled to the extraction unit, the implantation unit including a splitting needle configured to create an opening in a recipient site; a housing coupled to the extraction unit; and a user interface extending from the housing and movable relative to the housing. The user interface includes a pin movable within the coring needle relative to the housing.

There is provided a device for skin bioprinting and a method of making a device for skin bioprinting, the device comprising: a dispenser module configured to actuate and dispense a bioink from a first chamber, and to actuate and dispense a crosslinker from a second chamber: a storage module coupled to the dispenser module, the storage module comprising the first chamber for storing the bioink and the second chamber for storing the crosslinker; a mixing module coupled to the storage module for mixing the bioink and the crosslinker dispensed from the first and second chambers respectively; and a rotatable applicator coupled to the mixing module for rotatably applying a mixture of the bioink and crosslinker from the mixing module onto a surface of a patient in need of skin regeneration.

The invention relates to a device (14, 14 ') for loading a hair graft into an implantation instrument of the Choi implant type, said device comprising an element comprising: a first aperture (18a) connected to a channel (17) leading to a fluid discharge chamber (21); a second aperture (22) connectable to the fluid discharge chamber (21) and defining, together with the channel (17), a path in order to allow a needle (5) of an implanted instrument (1) to be introduced into the path through the second aperture (22); and a connection member (23) for connecting the fluid discharge chamber (21) to a vacuum source (27). The first aperture (18a) is connected to a first conduit (20) for delivering a graft (12) such that the graft (12) can be inserted into the needle (5) of the implant instrument (1).

Disclosed herein are compositions comprising an oligonucleotide that targets DKK2. The oligonucleotide may include a small interfering RNA (siRNA) or an antisense oligonucleotide (ASO). Also provided herein are methods of decreasing DKK2 expression by providing an oligonucleotide that targets DKK2 to a subject in need thereof. Some embodiments include methods of treating hair loss by providing the oligonucleotide.

A hair implant suitable for subcutaneous implantation is provided which has an anchor comprising an anchor body having a proximal end and a distal end; at least one collagen receiving structure selected from the group consisting of at least one tunnel disposed through the anchor body; and at least one hair strand projecting from said distal end of the anchor body and wherein said at least one hair strand comprises a primary hair element having a first end formed in said distal end and having a free end, opposite said first end, and wherein said primary hair element comprises at least one emerging hair element that originates from said primary hair element at a predetermined distance above said distal end.

To provide a mesh assembly having improved fixing force and pulling force for biological tissues and having an excellent effect of coming in close contact with skin tissues and maintaining and fixing the skin tissues.SOLUTION: There may be provided a mesh assembly having improved fixing force and pulling force for biological tissues and having an excellent effect of coming in close contact with skin tissues and maintaining and fixing the skin tissues. The mesh assembly is inserted in skin tissues of a human body, and may include a mesh member in which a plurality of linear members crossing each other are formed in a cylindrical shape.SELECTED DRAWING: Figure 2

The specification relates to a method of manufacturing a diabetic foot patient-specific skin regeneration sheet, and a diabetic foot patient-specific skin regeneration sheet. The method includes extracting autologous adipose tissue, removing fibers in the autologous adipose tissue, crushing the autologous adipose tissue, and acquiring an adipose tissue extract by filtrating the crushed autologous adipose tissue.

The present invention discloses a novel method for developing Human HLA-a / b / c triple knockout hair follicle stem cells (HFSCs) intended for promoting HFSCS transplantation. The method involves precise genetic modification techniques to knockout HLA-a / b / c genes, facilitating enhanced compatibility and effectiveness in hair follicles transplantation. The inventive approach aims to address challenges (donor dependent and large scar) in hair implantation therapy by leveraging advanced gene-editing and stem cell technologies.

Method and apparatus for automated staging of hair grafts using a camera for capturing one or more images of a staging area constructed for holding the hair grafts, and a controllable robotic arm having an aspiration tip mounted at a tool end thereof. An image captured by the camera is processed to identify a position of a hair graft in the image, and subsequent to distinguishing between a base end and a hair end of the hair graft in the image, an aspiration point is defined based at least in part on position of either or both of the base end and the hair end. The robotic arm is controlled to move the aspiration tip to the aspiration point, for aspiration of the hair graft into the aspiration tip. The aspirated graft may then be dispensed to a holding cartridge, sorted by number of hair grafts, or may be aspirated directly from the aspiration tip to a loading position in a hair implantation device, or to a loading position in a helper device for subsequent loading of the hair graft to a hair implantation device.

Provided is an automatic hair transplant device capable of stably taking out a hair material from a storage container and transplanting the hair material. The automatic hair transplant device includes a storage container having an outlet at a bottom thereof, the storage container placing a hair material across the outlet on the bottom. Furthermore, the automatic hair transplant device includes an energizing part configured to apply a force to the hair material, the force having a component in a direction away from the outlet.

A structure of aligned (e.g., radially and / or polygonally aligned) fibers, and systems and methods for producing and using the same. One or more structures provided may be created using an apparatus that includes one or more first electrodes that define an area and / or partially circumscribe an area. For example, a single first electrode may enclose the area, or a plurality of first electrode(s) may be positioned on at least a portion of the perimeter of the area. A second electrode is positioned within the area. Electrodes with rounded (e.g., convex) surfaces may be arranged in an array, and a fibrous structure created using such electrodes may include an array of wells at positions corresponding to the positions of the electrodes.

Provided is a method for producing a skin organoid, the method comprising: a step for performing a first culture of a primary skin cell in a first medium with at least one support among an extracellular matrix (ECM) and polyethylene glycol (PEG) to form a first skin organoid; and a step for performing a second culture of the first skin organoid in a second medium. In addition, the present disclosure provides: a skin organoid cultured by the method described above, the skin organoid having a round, spherical, three-dimensional shape and comprising a center portion, which is densely packed with cells, a stratum corneum formed on the outside of the center portion, and a hair root, wherein the cells can move from the center portion to the stratum corneum; and a method for evaluating drug toxicity by using same.

The present invention relates to a bioabsorbable implantable device (100) comprising a base structure including at least one base layer (10), said base structure comprising: an assembly A (1A) including a layer of a plurality of elongated elements A1 (1A1) and a layer of a plurality of elongated elements A2 (1A2) oriented in a longitudinal direction LA1; and an assembly B (1B) including a layer of a plurality of elongated elements B1 (1B1) and a layer of a plurality of elongated elements B2 (1B2) oriented in a longitudinal direction LB1, said assembly B (1B) being at least partially disposed on said assembly A (1A), said direction LA1 intersecting said direction LB1, said base structure comprising a plurality of base layers disposed at least partially overlapping each other.

A skin grafting system having a handheld device, a cartridge, and a device shield. The handheld device includes a device housing forming an interior that secures a drive system. The cartridge includes a plurality of hollow microneedles surrounded by a peripheral housing and is configured to be operated by the drive system to extend and retract past the peripheral housing into a subject to harvest tissue during a skin grafting process. The device shield is formed of a polymer extending from an interior opening to an exterior edge, the interior opening sized to extend about the peripheral housing to positon the exterior edge over the device housing to control ingress of fluids into the interior of the device housing from fluid about the peripheral housing of the cartridge during the skin grafting process performed using the skin grafting system.