230results about "Skin implants" patented technology

There is disclosed a packaged allograft implant configured for implantation in a human recipient. In an embodiment, the packaged allograft implant includes an acellular dermal matrix sheet having a top surface and a bottom surface in opposition to one another, a perimeter surrounding the top surface and the bottom surface, and a thickness extending between the top surface and the bottom surface. The packaged allograft implant further includes a mesh pattern extending across at least a portion of the top surface and the bottom surface of the acellular dermal matrix sheet, the mesh pattern providing through-holes extending between the top surface and the bottom surface of the acellular dermal matrix sheet, and the mesh pattern having a plurality of mesh lines extending in a first direction and a second direction. The first direction and the second direction are orthogonal to one another so as to allow a given amount of stretch in each of the first direction and the second direction. Other embodiments are also disclosed.

Allografts for soft tissue repair, including breast reconstruction and other plastic surgery procedures, are disclosed. In an exemplary embodiment, first and second cuts are made into the reticular layer of a skin sample to separate an improved acellular dermal matrix (ACDM) which forms a dermal tissue form useful as a graft. The dermal tissue form consists essentially of reticular dermis and has a first exposed surface formed by reticular dermis, an opposite second exposed surface formed by reticular dermis, and has substantially uniform density and uniform porosity between the first and second exposed surfaces, which allows and promotes rapid and efficient cellular ingrowth and tissue ingrowth substantially equally from either the first or second exposed surfaces upon implantation.

The invention provides a bionic flexible force sensor based on a tenon-and-mortise structure and a high-performance medical patch material, belongs to the technical field of biomedical engineering, and can be used for multiple organ tissues such as myocardium and skin. The bionic flexible force sensor is provided with an upper base and a lower base; the upper base and the lower base are of a concave-convex interlocking tenon-and-mortise structure. A plurality of convex tenons are designed on the bottom surface of the upper base, a plurality of concave mortises corresponding to the tenons are designed on the top surface of the lower base, and the tenons and the mortises are precisely matched to form stable locking; the tenons and the mortises are connected through buckle structures, and sliding and loosening are prevented. The bionic flexible force sensor is integrated and fixed on the surface or inside the medical patch through a micro-adhesion technology. A renewable wood-based enhanced visible light 3D printing technology is adopted, and nanofibers, nanocrystals and composite nanoparticles are combined, so that the patch material has excellent mechanical properties, electrical conductivity and drug controlled release property.

A system and method for controlling clinical soiling is provided. The system includes a device cover formed from a flexible polymer sheet defining an interior volume for a skin grafting device and including at least a first opening configured to receive a portion of the skin grafting device. The system further includes a band including a gasket secured to an outer periphery of the first opening of the device cover, the gasket configured to secure the device cover to the skin grafting device around the first opening and to inhibit infiltration of fluids into the interior volume of the device cover during a skin grafting process using the skin grafting device.

Provided is a bioelectrode having excellent mechanical and chemical durability as well as excellent air permeability and flexibility, and specifically, the bioelectrode includes: a nanofiber elastic mesh sheet including a polymer nanofiber formed by electrospinning; a first metal nanowire network which is embedded on the nanofiber elastic mesh sheet, but is at least partially exposed to the outside; and an uneven layer resulting from a second metal which is placed on the first metal nanowire network exposed to the outside.

A structure of aligned (e.g., radially and / or polygonally aligned) fibers, and systems and methods for producing and using the same. One or more structures provided may be created using an apparatus that includes one or more first electrodes that define an area and / or partially circumscribe an area. For example, a single first electrode may enclose the area, or a plurality of first electrode(s) may be positioned on at least a portion of the perimeter of the area. A second electrode is positioned within the area. Electrodes with rounded (e.g., convex) surfaces may be arranged in an array, and a fibrous structure created using such electrodes may include an array of wells at positions corresponding to the positions of the electrodes.

The harvesting of hair for a hair transplant procedure with immediate placement of the hair grafts to the balding area, employs a hollow drill connected to a suction with an imaging system (containing one or more cameras) which permits alignment of the center of the cutting edge of the needle on or slightly offset from the axis of the hair within the follicular unit to be removed. This harvesting tool may be robotically controlled. As each follicular unit may have more than one hair, the surgeon controls the number of hairs in each graft he wishes to remove, excising the graft one at a time. A special FUE tool is used that excises the entire follicular unit with minimal residual attachments. The tool utilizes vacuum to facilitate complete excision. The graft that is excised is sucked though tubing and almost instantaneously delivered to an implanter held by the surgeon (Duplex Implanter) or by a robot. This graft on Demand system is controlled by the surgeon through a series of commands to the handpiece of the implanter for one, two, three or more hair grafts. The excision needle (punch) is placed to remove a hair graft with the chosen number of hairs, taken from an area which has been previously mapped out. When properly aligned, a follicular unit is removed without damaging critical anatomical portions of the follicles and it is delivered to the implanter at the command of the surgeon. In one embodiment, a movable x / y / z stabilizing gantry is employed to position the hollow needle in each instance which can be manually controlled by the surgeon, or robotically controlled with one or more robots. In another embodiment, a computer maps out the location of every graft within the surgical field of view, in part or in whole, and selects those follicles, minimizing the spacing left remaining after each excision while obtaining the number of grafts targeted by the surgeon. In still another embodiment, one or more robotic arms, controlled automatically by a controller or manually by a surgeon, operate graft excision instruments to facilitate speed and accuracy of the excision process.

This invention relates to a curved needle for the injection of dermal fillers into the lips and perioral area.

The utility model discloses a skin defect in-situ printer which comprises a containing box body, reciprocating lifting assemblies are symmetrically and fixedly installed on the two sides of the inner wall of the containing box body, synchronous driving assemblies are correspondingly and fixedly installed at the bottoms of the two reciprocating lifting assemblies, and a lifting table is fixedly installed between the two reciprocating lifting assemblies. A first rotating assembly is fixedly installed on the upper surface of the lifting table, a lifting assembly is fixedly installed at the top end of the first rotating assembly, a second rotating assembly is fixedly installed on one side of the lifting assembly, a telescopic assembly is fixedly installed on the front side of the second rotating assembly, and a third rotating assembly is fixedly installed at the front end of the telescopic assembly. According to the skin defect in-situ printer, multi-angle adjustment and lifting telescopic adjustment are facilitated, storage and carrying are facilitated, the protection and dust prevention effects can be achieved in an auxiliary mode, convenience is brought to printing and using of a user, and the using requirement is well met.

The utility model discloses a skin extrusion / ink-jet composite printing device, which belongs to the technical field of biological tissue printing and comprises a computer, a three-dimensional motion system, an ink box, an ink-jet printing head, an extrusion printing head, a temperature control substrate, an air pump and a pressure controller. The ink box is installed on the ink-jet printing head, and the ink-jet printing head and the extrusion printing head are installed on the three-dimensional motion system. The pressure controller is mounted on the air pump; the pressure controller is in air connection with the ink box and the extrusion printing head; the computer is electrically connected with the three-dimensional motion system, the ink-jet printing head and the pressure controller. The computer is used for controlling the three-dimensional motion system to move and further used for controlling ink jet of the ink jet printing head and controlling the pressure controller to output the air pressure value. The personalized skin printing device provided by the utility model is low in manufacturing cost and high in efficiency.

The present invention provides a skin in-situ printing device for applying biological glue and a cross-linking agent to a predetermined part of a patient, and has the following characteristics: a platform device for carrying and rotating a patient; a print head device for applying the biological glue and the cross-linking agent to a predetermined part, and having a bracket unit and a nozzle unit arranged on the bracket unit; a coating power device for providing power to squeeze the biological glue and the cross-linking agent out of the nozzle unit during coating; a three-axis moving device for driving the print head device to move to a predetermined part; and a control device for controlling the above-mentioned devices, wherein the nozzle unit has a first nozzle assembly including a first barrel and a first needle and a second nozzle assembly including a second barrel and a second needle, the second barrel and the second needle respectively surround the first barrel and the outside of the first needle and have a first gap and a second gap, the first gap is connected to the second gap, and the lower end of the second needle is lower than the lower end of the first needle.

A packaging system (10b) is provided that includes a packaging body defining a cavity (14b) and a seal (18b) configured to be joined to the packaging body to fluidly seal the cavity. The packaging system may also include at least one tissue cradle (16b) configured to be disposed within the cavity. A cavity having a single size may be configured to accommodate differently sized tissue cradles. In addition to the cavity the packaging system may include one or more additional reservoirs configured for holding a volume of liquid. Such packaging systems may be used in the storage of wet-preserved or dry-preserved human or animal tissue. Also provided are a packaged tissue specimen and a method for packaging tissue.

The invention discloses a multi-scale artificial dermal scaffold and a preparation method thereof, and belongs to the technical field of tissue engineering and biomedical materials. The artificial dermal scaffold is of a three-dimensional porous structure formed by microfilaments of a first frame and a second frame, the microfilaments of the second frame are distributed in pores of the first frame, disordered microfilaments which do not affect the penetrability of the macropores are arranged in the macropores in the top surface of the first frame, and longitudinally aligned microfilaments are arranged in the micropores in the section of the first frame. Through the specific structure, the adhesion, proliferation and migration effects of cells can be remarkably improved, and rapid vascularization of artificial dermis is facilitated. In addition, the preparation process of the artificial dermal scaffold is simple and easy to operate, can be used for batch preparation, and has a good application prospect.

The present invention relates to a dental / medical device consisting of an absorbable synthetic membrane, preferably in the color of white to gray, comprising poly (dioxanone) and optionally graphene and stem cells for guided tissue reconstruction and / or regeneration of bone defects and other connective tissues, such as gingiva, skin, cartilage or cornea. Furthermore, the invention relates to the use of said device for the above related applications and to a method for producing said device.

The present invention relates to a dental / medical device that comprises poly(dioxanone) (PDO or PDS), preferably has an absorbent synthetic film exhibiting a color from white to grey, and is applied in the medical and dental fields. The dental / medical device may have stem cells and graphene used for inducing tissue reconstruction and / or inducing tissue regeneration of bone defects and other connective tissues (such as gingiva, skin, cartilage, cornea, etc.). Further, the present invention relates to the use of the device for the related applications described above and a method for manufacturing the device.

Systems and methods are disclosed that include determining medical treatment parameters based on a desired appearance. The system includes a camera, a display, and a processing system. The system may also include a projection device or system. The camera may capture one or more digital images of a body part of a subject. The display may display one of the digital images captured by the camera and allow inputs through a touchscreen user interface that alter a characteristic of the body part of the subject based on a desired appearance of the subject. The processing system may analyze the inputs and the desired appearance of the subject to calculate a medical treatment designed to achieve or to correspond to the desired appearance in the subject.

The present invention relates to a bioresorbable implantable device comprising a base structure comprising at least one base layer (10) comprising: • - an assembly A (1A) comprising a layer of a plurality of elongate elements A1 (1A1) which are oriented in a longitudinal direction LA1, and a layer of a plurality of elongate elements A2 (1A2); an assembly B (1B) comprising a layer of a plurality of elongate elements B1 (1B1) which are oriented in a longitudinal direction LB1, and a layer of a plurality of elongate elements B2 (1B2); • - the assembly B (1B) is placed at least partially on top of the assembly A (1A); • - the direction LA1 intersects the direction LB1; and • - the base structure comprises a plurality of base layers placed at least partially one on top of the other.

The present invention provides a skin in-situ printing device for applying bio-glue and cross-linking agent to a predetermined part of a patient, and has the following characteristics, including: a platform device for carrying and rotating a patient; a print head device having a support unit and a nozzle unit; a storage device including a first storage device and a second storage device; a coating power device for providing coating power to the storage device; a three-axis moving device for driving the print head device to move to a predetermined part; and a control device, wherein the nozzle unit has a first nozzle and a second nozzle, the first nozzle has a first tube portion and a first nozzle head portion, the two ends of the first tube portion are respectively connected to the first storage device and the first nozzle head portion, the second nozzle has a second tube portion and a second nozzle head portion, the two ends of the second tube portion are respectively connected to the second storage device and the second nozzle head portion, the second nozzle extends and passes through the tube wall of the first tube portion, so that the second nozzle head portion is located at the central axis position of the inner cavity of the first tube portion.

The harvesting of hair for a hair transplant procedure with immediate placement of the hair grafts to the balding area, employs a hollow drill connected to a suction with an imaging system (containing one or more cameras) which permits alignment of the center of the cutting edge of the needle on or slightly offset from the axis of the hair within the follicular unit to be removed. This harvesting tool may be robotically controlled. As each follicular unit may have more than one hair, the surgeon controls the number of hairs in each graft he wishes to remove, excising the graft one at a time. A special FUE tool is used that excises the entire follicular unit with minimal residual attachments. The tool utilizes vacuum to facilitate complete excision. The graft that is excised is sucked though tubing and almost instantaneously delivered to an implanter held by the surgeon (Duplex Implanter) or by a robot. This graft on Demand system is controlled by the surgeon through a series of commands to the handpiece of the implanter for one, two, three or more hair grafts. The excision needle (punch) is placed to remove a hair graft with the chosen number of hairs, taken from an area which has been previously mapped out. When properly aligned, a follicular unit is removed without damaging critical anatomical portions of the follicles and it is delivered to the implanter at the command of the surgeon. In one embodiment, a movable x / y / z stabilizing gantry is employed to position the hollow needle in each instance which can be manually controlled by the surgeon, or robotically controlled with one or more robots. In another embodiment, a computer maps out the location of every graft within the surgical field of view, in part or in whole, and selects those follicles, minimizing the spacing left remaining after each excision while obtaining the number of grafts targeted by the surgeon. In still another embodiment, one or more robotic arms, controlled automatically by a controller or manually by a surgeon, operate graft excision instruments to facilitate speed and accuracy of the excision process.

A packaging system is provided. The packaging system may include a packaging body defining a cavity. The packaging system may also include a tissue cradle configured to be disposed within the cavity. The packaging system may also include a seal configured to be joined to the packaging body to fluidly seal the cavity. Such packaging systems may be used in the storage of wet-preserved or dry-preserved human or animal tissue. Also provided are a packaged tissue specimen and a method for packaging tissue.

Provided herewith is a needle for delivering dermal filler thread to a wrinkle in a patient. The needle can also be used to deliver the thread to a patient for the purposes of facial contouring. The needle comprises a coupler for attaching the thread to the needle and also a trocar to ease delivery through the skin.

The specification relates to a method of manufacturing a diabetic foot patient-specific skin regeneration sheet, and a diabetic foot patient-specific skin regeneration sheet.

The present invention provides an apparatus for skin bioprinting and a method of manufacturing an apparatus for skin bioprinting, the apparatus comprising: a dispenser module configured to drive and dispense bio-ink from a first chamber and to drive and dispense a cross-linking agent from a second chamber; a storage module connected to the dispenser module, the storage module including a first chamber storing bio-ink and a second chamber storing a cross-linking agent; a mixing module connected to the storage module, the mixing module mixing the bio-ink and the crosslinking agent dispensed from the first and second chambers, respectively; and a rotatable applicator connected to the mixing module, the rotatable applicator rotatably applying a mixture of bio-ink and cross-linking agent from the mixing module to a surface of a patient in need of skin regeneration.

A lightweight reinforced mesh, such as a surgical mesh, suitable for use in various applications, including breast reconstruction, cosmetic breast surgery, mastopexy, breast augmentation, breast reduction, soft tissue reconstruction, hernia repair, tissue plication reinforcement, tissue support and repair, tendon support and repair, tissue engineering, and procedures or other applications requiring additional soft tissue strength or thickness. In addition, disclosed is a use of such a mesh for tissue engineering, regardless of the surgical application. In particular, the present disclosure relates to a surgical mesh capable of providing enhanced support while maintaining flexibility, low density, and absorbable characteristics. Further the present disclosure, focuses on reducing the material burden of a scaffold while increasing void space to facilitate tissue ingrowth.

To provide a tissue filler that allows a host cell to quickly get into the tissue filler and also allows the host cell to be engrafted in it, and has sufficient mechanical strength.SOLUTION: A tissue filler includes porous collagen sponge including a honeycomb structure inside it, and fibrillar collagen contained in the lumen of the honeycomb structure.SELECTED DRAWING: Figure 1

A universal biological prosthesis of acellular dermal matrix (ADM) intended for use in body reconstruction processes and method of manufacture. A universal biological prosthesis of acellular dermal matrix (ADM) intended for use in body reconstruction processes, comprising: a first layer of ADM of biological origin arranged inferiorly to delimit a cavity with a lower edge; a filling material disposed in the cavity surrounded by the first layer of ADM consisting of a ground ADM having the consistency of a fibrous paste; and a second layer of ADM of biological origin arranged on the upper part covering the filling material and whose upper edge rests peripherally on the lower edge of the first layer of ADM, thus defining a rim;where the first layer of ADM and the second layer of ADM are joined by an eyebrow overlap along the upper edge of the first layer of ADM with the lower edge of the peripheral rim using a biocompatible adhesive, or by absorbable suture; where the first layer of ADM, the second layer of ADM and the ADM filling material are not immunogenic; and where the ADM comprises collagen fibers, fibronectin, elastin, laminin, glycosaminoglycans and hyaluronic acid. Method for its manufacture.

An extraction device, including a motor, a driveshaft operatively coupled to the motor and driven to rotate thereby, a punch tool directly coupled to a distal end of the driveshaft to rotate therewith, and arranged to be in physical contact with a skin layer during operation of the extraction device, a force sensor operatively coupled to the driveshaft to measure a force exerted thereupon by the skin layer, and a controller communicatively coupled to the motor and to the force sensor. The controller is configured to define multiple rotary modes and multiple multiphasic modes, each multiphasic mode including at least two rotary modes, receive a selection of a multiphasic mode, and provide, based on the selection, a control signal to the motor instructing the motor to operate in the multiphasic mode.

The present invention relates to the technical field of burn patches, and particularly to a burn patch for treating skin wounds and a preparation method thereof. The method includes: dissolving the active ingredients and the collagen into a solvent using a stirrer to output a mixed solution; bonding the silica gel with the nylon textile fabric to output a film patch; coating the mixed solution on one side of the nylon textile fabric of the film patch; drying the film patch coated with the mixed solution using a hot air circulation oven; cutting the dried film patch using a cutting machine; punching holes on the silica gel side of the cut film patch to output a burn patch; determining the preparation stability of the burn patch based on the variance of the concentration of the mixed solution; if the preparation stability does not meet the requirements, adjusting the rotation speed of the stirring motor of the stirrer; if the forming effectiveness does not meet the requirements, adjusting the tool feed of the cutting machine. The present invention improves the preparation stability of the burn patch.

Disclosed herein are compositions comprising an oligonucleotide that targets DKK2. The oligonucleotide may include a small interfering RNA (siRNA) or an antisense oligonucleotide (ASO). Also provided herein are methods of decreasing DKK2 expression by providing an oligonucleotide that targets DKK2 to a subject in need thereof. Some embodiments include methods of treating hair loss by providing the oligonucleotide.