The invention belongs to the technical field of medical materials, and relates to a preparation method of an integrated gradual
change type bionic gradient structure
rotator cuff patch. The integrated gradual
change type bionic gradient structure
rotator cuff patch is prepared through the electric auxiliary solution blowing
spinning technology and the heat treatment nanoimprint technology, the patch is of a composite layer structure, each
transition layer and the adjacent micro-nano
fiber membrane layer form a continuous fracture-free structure, the internal structure and component change are in uniform transition, discrete layering is avoided, and the patch has good application prospects. The whole patch is of a continuous gradual
change type biological bionic gradient structure, histological gradient characteristics of a
tendon-bone transition area are successfully simulated, and rapid healing of a
tendon-bone interface can be effectively promoted.