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1194 results about "Percutaneous" patented technology

In surgery, a percutaneous procedure is any medical procedure or method where access to inner organs or other tissue is done via needle-puncture of the skin, rather than by using an "open" approach where inner organs or tissue are exposed (typically with the use of a scalpel).

Blood pump

The invention concerns a control device for controlling a blood flow of an intravascular blood pump for percutaneous insertion into a patient's blood vessel, the blood pump comprising a pump unit with a drive unit for driving the pump unit and configured to convey blood from a blood flow inlet towards a blood flow outlet, wherein the control device is configured to operate the blood pump in a selectable zero-flow control mode, wherein a blood flow command signal is selected, and the control device comprises a first controller and a second controller, wherein the first controller is configured to control the blood flow by adjusting a speed command signal for the drive unit, and the second controller is configured to control a drive speed of the drive unit.
Owner:ABIOMED EUROPE GMBH

Intracardiac percutaneous pump for circulatory support and related systems and methods

A device comprises an implantable blood pump receivable in a sheath for percutaneous delivery. The implantable blood pump comprises a collapsible impeller mounted in a collapsible impeller cage, and a drive device mounted in a housing. The housing is in connection between a first end of a catheter and the collapsible impeller cage. The drive device is adapted for rotating the collapsible impeller. A retractable support structure is adapted to extend from the catheter. The extended retractable support structure is adapted to engage with the wall of the aorta for allowing the implantable blood pump to be secured in the left ventricle. The collapsible impeller cage comprises an inlet and an outlet. The inlet is adapted to receive blood from the left ventricle. The outlet directs blood in the direction of the atrioventricular valve.
Owner:VENSSTREETCAREDICAL PTY LTD

Percutaneous spinal nerve electrical stimulation system and method

PendingCN119455255Aimprove accuracyInsufficient improvementSensorsDiagnostic recording/measuringSpinal nerveElectrical stimulations
The invention relates to the technical field of exercise rehabilitation, and discloses a percutaneous spinal nerve electrical stimulation system and method, and the system comprises a power module which is used for converting an external alternating current into a stabilized power supply; the MCU module controls the pulse signal generation module; the pulse signal generation module is used for generating an electrical stimulation waveform; the DAC module receives the digital signal; the modulation module is used for receiving analog signals; the amplification module is used for receiving modulation waveforms; the multi-channel gating module is used for distributing stimulation current to a plurality of channels; the current detection module monitors the magnitude of current output by each channel in real time; and the ADC module performs digital conversion on the current analog signal output by the electrical stimulator. According to the invention, multi-channel and real-time modulation electrical stimulation signals can be output through modulation of two paths of stimulation signals, spinal cord sensory nerves are activated through the non-invasive epidermal electrode, amputation hand feeling is induced, the defect that electromyographic signals are interfered by the tail end of a stump in the prior art is improved, and the accuracy of an electromyographic signal decoding algorithm is also improved.
Owner:CHONGQING COLLEGE OF ELECTRONICS ENG

Anesthesia injury monitoring evaluation and management system for pain monitoring and rehabilitation acceleration

The invention relates to the field of medical instruments, and discloses an anesthesia injury monitoring evaluation and management system for pain monitoring and rehabilitation acceleration. Comprising a sensor module configured to collect acupuncture point skin temperature data in a percutaneous acupuncture point electrical stimulation process, current parameter data output by an electrical stimulation device and skin impedance change data in real time; the control module is used for inputting the temperature data, the current parameter data and the skin impedance data which are acquired in real time into a multi-parameter risk assessment model, calculating a real-time risk value and generating a parameter change curve containing a time sequence; when the real-time risk value exceeds a preset safety threshold value, or any single parameter in the parameter change curve reaches a temperature change rate threshold value, an accumulated electrical stimulation energy threshold value or a skin impedance abnormal fluctuation threshold value, triggering a multi-stage early warning signal; according to the early warning level of the early warning module, the output power, the pulse frequency or the action time of the electrical stimulation device is automatically adjusted, or electrical stimulation is forcibly terminated when early warning is performed at the highest level.
Owner:BOCE BIOMEDICAL (TIANJIN) CO LTD

Percutaneous nerve field vagus nerve stimulation diagnosis and treatment equipment and diagnosis and treatment method thereof

The invention discloses percutaneous nerve field vagus nerve stimulation diagnosis and treatment equipment and a diagnosis and treatment method thereof, and particularly relates to the technical field of neuromedicine, intelligent medical equipment and multi-mode physical therapy. The equipment comprises a neural signal acquisition module, a nerve positioning module, a data processing and analysis module, a treatment execution module and a diagnosis result output module; the system is further provided with a battery power management module, a self-adaptive closed-loop cloud platform and a wearable fixing device, by collecting bioelectricity signals, light absorptivity and temperature data of an ear nerve area, ear target cranial nerve branches are positioned, a dynamic diagnosis map is constructed, and a diagnosis result and personalized treatment parameters are generated. Electric pulse, near-infrared light and local thermal therapy multi-mode collaborative stimulation is adopted for treatment, and parameters are monitored and adjusted in real time through a cloud platform. According to the invention, accurate diagnosis and personalized treatment can be realized, the medical efficiency and the treatment effect are improved, and an effective means is provided for nerve disease diagnosis and treatment and pain relief.
Owner:SHANGHAI AIKAI MEDICAL TECH CO LTD

Ear and neck percutaneous vagus nerve stimulation device based on internal perception signal

The invention discloses an ear and neck percutaneous vagus nerve stimulation device based on an internal feeling signal, which belongs to the related technical field of percutaneous vagus nerve stimulation and is composed of a physiological signal acquisition module, a data transmission module, a signal processing and analyzing module, a control module, ear and neck integrated stimulation equipment, an interaction module and a power supply. The device supports neck or ear vagus nerve stimulation and a stimulation mode of combined use of the neck and the ear vagus nerve. And the same or different stimulation parameters can be used for the vagus nerves of the ears and the neck. According to the non-invasive design, the electrode does not need to be placed in a human body through an operation, nerves are stimulated through an external stimulator, and the risk of injury to the human body is reduced; and meanwhile, the output of two stimulation parameters taVNS and tcVNS can be adjusted adaptively through physiological signals and internal feeling indexes, and the fusion effect is improved.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY +1

Percutaneous tricuspid valve repair devices and methods

A first ventricular surface anchor may be placed against the first right ventricular surface, where the first ventricular surface anchor is connected to a first tension member. A first tension anchor against a tension anchor surface of the heart wherein the first tension anchor is connected to a second tension member. The first tension member connected to the first ventricular surface anchor may extend toward the second tension member connected to the first tension anchor; and the first tension member and the second tension member may drag the first right ventricular surface toward the first tension anchor. The surface anchor may include a nitinol frame and an aperture forming an outer perimeter. When the temperature of the nitinol frame is a body temperature, the nitinol frame may have an austenitic state in a deployed configuration. The surface anchor may also include a grommet including a distal tubular portion connected to a proximal finger portion.
Owner:TANGENTIAL CARDIOVASCULAR CO

Bifurcated hub

There is provided an introducer system for percutaneously delivering a first and a second medical device to a patient. The system may comprise an introducer sheath having a longitudinal axis and a lumen formed therein. The system may also comprise a bifurcated hub coupled to a proximal end of the sheath. The hub may comprise a first arm having a first lumen and a first hemostasis valve for the passage of the first medical device. The hub may also comprise a second arm coupled to the first arm and having a second lumen and a second hemostasis valve for the passage of the second medical device. Further, the hub may comprise a connection port such that the first lumen and the second lumen are in communication with the lumen of the introducer sheath for the passage of at least one of the first and second medical devices through the introducer sheath for delivery to the patient.
Owner:ABIOMED INC

Remote control module for adjustable implants

The present disclosure broadly provides applications of communication at ultrasound frequencies to establish transcutaneous data communication between medical devices located on and / or within a body of a patient, including inter alia: features for adjustable implants including data communication, hermetic containment, and torque amplification features.
Owner:NUVASIVE SPECIALIZED ORTHOPEDICS INC

One-way flap type percutaneous nephroscope calculus removing device

The utility model discloses a one-way flap type percutaneous nephroscope calculus removing device which comprises a working sheath and a cylinder calculus removing device, the cylinder calculus removing device is movably connected with the working sheath, the cylinder calculus removing device comprises a fence structure composed of an upper lantern ring, ribs and a lower lantern ring, the ribs are connected with the upper lantern ring, and the lower lantern ring is connected with the lower lantern ring. The inner wall of the bottom end of the cylindrical stone extractor is detachably connected with a valve piece assembly used for preventing stone fragments from returning into the kidney, by means of the cylindrical stone extractor, the front stone can be seen through an endoscope camera installed at the rear end of the cylindrical stone extractor, and therefore the stone extraction efficiency is improved. The fence-shaped hollow structure facilitates observation and drainage, it is guaranteed that stone fragments are locked once entering the cylindrical stone extractor, the stone fragments are prevented from backing back into the kidney, the situation that the operation time is prolonged and larger trauma is caused to a patient is avoided, and the cylindrical stone extractor has certain use value and popularization value.
Owner:YUYING MEDICAL INT CO LTD

Percutaneous pericardiocentesis assembly and system

ActiveCN120267375ADiagnosticsSurgical needlesPericardial WallPuncture procedure
The percutaneous pericardium puncture assembly comprises a puncture tube and a puncture piece, and the puncture tube comprises a tube body and a puncture section arranged at the far end of the tube body. A puncture channel, a negative pressure suction channel and an imaging channel are formed in the tube body and communicated with a working opening in the far end of the puncture section. The imaging module is arranged in the imaging channel in a penetrating mode, and real-time visualization of in-vivo puncture operation is achieved. The near end of the negative pressure suction channel can be in butt joint with a negative pressure suction device to provide negative pressure for the working port so as to adsorb the pericardium wall layer; the puncture piece penetrates through the puncture channel and can puncture the adsorbed pericardium wall layer. According to the embodiment, the vacuum suction channel is formed, the pericardium wall layer can be captured before puncture of the puncture piece, in this way, even if only a small amount of pericardial effusion exists between the pericardium wall layer and the pericardium dirty layer, medical staff can easily complete puncture of the pericardium wall layer under the condition that the pericardium dirty layer is not damaged, and the puncture efficiency of the pericardium wall layer is improved. The operation is simple, and the safety and the success rate of percutaneous pericardium paracentesis under full indications are greatly improved.
Owner:BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV

Systems, methods and devices for peripheral neuromodulation

ActiveUS12357824B2External electrodesArtificial respirationPosterior tibial nerveSaphenous nerve
In some embodiments, systems and methods can include a wearable device with an electrically conductive skin interface that excites the underlying nerves from a transcutaneous surface stimulator. The device may be sized for a range of user sizes with stimulation electrodes positioned to target the appropriate nerves, such as the saphenous and / or posterior tibial nerves. The therapy may be adjusted based on leg restlessness or movement.
Owner:CALA HEALTH INC

System for performing transcutaneous photodynamic therapy (PDT) in an organ or organ segment of an organic body

A system, for transcutaneous photodynamic therapy in an organ or organ segment of an organic body, includes a plurality of light applicators (9), a supply unit (23) and a placement template (39) placeable relative to the organic body for defined orientation of the light applicators. The light applicators include a needle-shaped insertion portion (15) for transcutaneous piercing along a piercing axis (E), a light-emitting applicator tip (19) at the distal end (13) of the insertion portion, and a fixing point (43) at a proximal distance d from the applicator tip. The placement template defines a plurality of fixing point receptacles (51) for fixing the light applicators with a defined fixing point and includes a first and second template parts (71, 75) defining first and second subsets (73, 77) of fixing point receptacles. The first template part is guidingly displaceable relative to the second template part along the piercing axis.
Owner:RICHARD WOLF GMBH

Percutaneous transvalvular intraannular band for mitral valve repair

ActiveUS12201526B2Annuloplasty ringsSurgeryMedicineThoracotomy
Mitral valve prolapse and mitral regurgitation can be treating by implanting in the mitral annulus a transvalvular intraannular band. The band has a first end, a first anchoring portion located proximate the first end, a second end, a second anchoring portion located proximate the second end, and a central portion. The central portion is positioned so that it extends transversely across a coaptive edge formed by the closure of the mitral valve leaflets. The band may be implanted via translumenal access or via thoracotomy.
Owner:HEART REPAIR TECH INC

Application and synthesis method of cyclic peptide

The invention relates to the technical field of cosmetics, in particular to application and a synthesis method of cyclic peptide. The inhibition objects of the cyclic peptide comprise IL-1beta, IL-6 and TNF-alpha (Tumor Necrosis Factor-alpha); when the concentration is less than or equal to 10ppm, the inhibition rate on IL-1beta is greater than or equal to 40%, the inhibition rate on IL-6 is greater than or equal to 50%, and the inhibition rate on TNF-alpha is greater than or equal to 40%. The cyclopeptide has a barrier repairing effect and can improve FLG expression; meanwhile, the moisturizing effect is achieved, and percutaneous moisture loss of the skin can be reduced. The invention provides a group of cyclic peptides, which has excellent anti-inflammatory, moisturizing, barrier repairing and soothing effects, and compared with the existing straight-chain peptides in the market, the group of cyclic peptides has more obvious anti-inflammatory and soothing effects, and has a certain skin barrier repairing effect. The group of cyclic peptides can be applied to the fields of cosmetics and skin care products, and the product efficacy is improved; and the synthetic method of the cyclic peptide is easy to implement and wide in application prospect.
Owner:SHANGHAI ZHONGYI DAILY CHEM CO LTD +1

Percutaneous medical device delivery system

A medical device delivery system including a delivery sheath that includes an internal lumen, and a plurality of delivery arms contained within the internal lumen of the delivery sheath and extending along a longitudinal axis of the internal lumen of the delivery sheath, wherein distal ends of the delivery arms include fasteners configured to engage with a basal structure of a medical device and a apical structure of the medical device, wherein the delivery arms are attached to delivery arm controls that are configured to advance the delivery arms and the medical device attached thereto out from a distal end of the delivery sheath, and removable release wires or release lines configured to engage with the fasteners to hold the basal structure and the apical structure in place at the fasteners. Also disclosed are methods of delivering a medical device to a subject including inserting a distal end of the medical device delivery system through an incision in the skin of subject, and deploying a medical device engaged with the delivery arms of the medical delivery system to within the body of the subject.
Owner:RGT UNIV OF CALIFORNIA

Efficient auxiliary equipment for percutaneous interventional operation

The invention relates to the field of surgical mechanical arms, and discloses percutaneous interventional surgery efficient auxiliary equipment which comprises a mounting plate, a control box is fixedly connected to the top of the mounting plate, a mechanical arm body is fixedly mounted at the top of the control box, a transmission box is fixedly connected to the interior of the mounting plate, and a motor is fixedly connected to the bottom of the inner wall of the transmission box; the right side of the transmission box communicates with a round sleeve, and the right end of an output shaft of the motor is fixedly connected with fan blades located in the round sleeve. According to the invention, the controller detects the temperature in the control box and intelligently controls the motor at the same time, then the motor exhausts air through the fan blades and the exhaust pipe to cool the element, and finally the speed reducer and the reciprocating screw drive the sleeve plate to move up and down through the moving sleeve. The sliding rod drives the exhaust pipe to rotate back and forth within a certain angle through the arc-shaped opening, the heat dissipation area is increased, the advantage of intelligent heat dissipation is achieved, and the situation of local overheating is not prone to occurring.
Owner:THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY

Percutaneous delivery systems for anchoring an implant in a cardiac valve annulus

ActiveUS12364604B2Suture equipmentsSurgical needlesAortic anulusMitral prolapse
Mitral valve prolapse and mitral regurgitation can be treating by implanting in the mitral annulus a transvalvular intraannular band. The band has a first end, a first anchoring portion located proximate the first end, a second end, a second anchoring portion located proximate the second end, and a central portion. The central portion is positioned so that it extends transversely across a coaptive edge formed by the closure of the mitral valve leaflets. The band may be implanted via translumenal access or via thoracotomy.
Owner:HEART REPAIR TECH INC

Nerve regeneration system and method

A stimulation device includes an adaptor component. The adaptor component couples a percutaneous lead to the stimulation device. The stimulation device may apply a stimulation signal to target tissue via the adaptor. A surgeon may place the stimulation device in a container and the adaptor component may be disposed outside of the container. Methods describe prolonged stimulation of target tissue via a stimulation device. The prolonged stimulation may be applied during and after a surgical procedure.
Owner:CHECKPOINT SURGICAL LLC

Multi-shield spinal access system

An access device for accessing an intervertebral disc having an outer shield comprising an access shield with a larger diameter (˜16-30 mm) that reaches from the skin down to the facet line, with an inner shield having a second smaller diameter (˜5-12 mm) extending past the access shield and reaches down to the disc level. This combines the benefits of the direct visual microsurgical / mini open approaches and the percutaneous, “ultra-MIS” techniques.
Owner:MEDOS INT SARL

Transdermal drug delivery controlled release disc and transdermal drug delivery equipment

The utility model relates to the technical field of medical equipment, and discloses a transdermal drug delivery controlled release disc and a transdermal drug delivery device.The controlled release disc comprises a disc body, a central drug delivery cavity and an annular negative pressure adsorption cavity are formed in the disc body, and the negative pressure adsorption cavity is located on the outer side of the central drug delivery cavity; the inner top end of the negative-pressure adsorption cavity is provided with at least one convex rib, the upper space of the negative-pressure adsorption cavity is divided into at least two adsorption areas through the convex ribs, the adsorption areas are distributed in the radial direction of the disc body, and the negative-pressure adsorption cavity is provided with negative-pressure openings communicated with the adsorption areas; the negative pressure adsorption cavity is arranged to enable the skin to be stretched to the adsorption area under the negative pressure effect and to be attached to the surface of the adsorption area. According to the transdermal drug delivery controlled release disc, the technical effects of improving the adsorption stability of the disc body on the skin and reducing the possibility that the disc body falls off from the skin are realized, and the problem that the transdermal drug delivery controlled release disc is easy to fall off when being adsorbed and fixed on the skin in the related technology is solved.
Owner:HUAXIA CHENGHUANG (BEIJING) HEALTH TECH CO LTD

Transluminal delivery system

A percutaneous delivery tool includes a shaft, and proximal and distal capsules which move axially with respect to the shaft. A prosthetic valve includes a tubular portion, an upstream support portion extending therefrom and a plurality of flanges each having a respective flange end-portion. The prosthetic valve is restrainable by the delivery tool, such that the shaft and a downstream end of the tubular portion are disposed within the distal capsule, and the upstream support portion and the flange end-portions are disposed within the proximal capsule. Other embodiments are also described.
Owner:CARDIOVALVE LTD

Treatment monitoring method and system for percutaneous ear vagus nerve stimulation device

The invention discloses a treatment monitoring method and system for a percutaneous ear vagus nerve stimulation device, and the method comprises the steps: carrying out the multi-source treatment situation monitoring of a target user in a treatment course, obtaining the multi-source treatment situation monitoring data, and constructing a multi-mode treatment situation feature; real-time treatment situation analysis is carried out according to the multi-mode treatment situation features, and real-time treatment situation analysis information is generated; performing dynamic state classification based on the real-time treatment situation analysis information, evaluating the treatment condition of the target user in the current treatment course, and generating a treatment regulation and control scheme to perform treatment management and control on the current treatment course when an abnormal treatment condition exists; and constructing a treatment situation prediction model, obtaining the regulated and controlled multi-mode treatment situation characteristics, generating a floating regulation and control boundary in combination with the treatment situation prediction model, and dynamically correcting the diagnosis and treatment regulation and control scheme by using the floating regulation and control boundary to ensure the curative effect and treatment safety. The treatment effect can be accurately perceived; and the treatment safety is ensured.
Owner:SHENZHEN SECOND PEOPLES HOSPITAL (SHENZHEN INST OF TRANSLATIONAL MEDICINE)

Implant for percutaneous minimally invasive thoracolumbar vertebral fracture

PendingCN120814892AInternal osteosythesisLumbar vertebral bodyLumbar spine
The invention relates to the technical field of bone implants for minimally invasive surgery, and particularly discloses an implant for percutaneous minimally invasive thoracolumbar vertebral fracture, which comprises a vertebral body forming body, the vertebral body forming body comprises a vertebral body forming body head and a plurality of blade parts arranged at the rear end of the vertebral body forming body head in a surrounding manner, the vertebral body forming body head is provided with a needle guide hole penetrating along the axial direction, and the needle guide hole is communicated with the blade parts; a containing cavity is defined by the blade parts; the front end of the threaded guide rod and the head of the cone forming body are integrally formed, the needle guide hole penetrates through the threaded guide rod in the axial direction, and the rear end of the threaded guide rod extends out of the containing cavity; the pedicle screw is provided with a threaded hole penetrating in the axial direction, the threaded hole is in threaded connection with the threaded guide rod, the pedicle screw comprises a screw head and a threaded part arranged at the rear end of the screw head, and the screw head is arranged in the containing cavity and expands the blade part. According to the implant for the percutaneous minimally invasive thoracolumbar vertebral fracture, surgical wounds are reduced, the vertebral restoration effect is good, the stability of a vertebral formed body is guaranteed, and the surgical time can be saved.
Owner:FOSHAN NANHAI DISTRICT GENERAL HOSPITAL (FOSHAN NANHAI DISTRICT GUICHENG HOSPITAL)

Percutaneous mechanical circulation support device

A medical system may include a pump disposed along a longitudinal axis of a blood flow assist system and including an impeller disposed in a pump housing; a power lead coupled with the first end portion of the pump; and a tether coupled with a second end portion of the pump opposite the first end portion. During operation of the blood flow assist system with the pump disposed within the blood vessel, the power lead may be configured to extend from within the blood vessel within which the pump is disposed to outside the first vascular access site to couple to the control system, and the tether may be configured to extend from within a blood vessel within which the pump is disposed to an anchoring position disposed away from the second end portion.
Owner:PROCYRION INC

Method for treating chronic insomnia by percutaneous magnetic stimulation of stellate ganglion block

PendingCN121550585AElectrotherapyDiagnostic signal processingStellate ganglion blockChronic insomnia
The invention relates to the field of medical treatment, and discloses a method for treating chronic insomnia by percutaneous magnetic stimulation of stellate ganglion block, which comprises the following steps: preprocessing: determining the initial position of stellate ganglion, tissue initial parameters and initial stimulation parameters through multi-modal image positioning and initialization to obtain reference data; dynamic sensing: collecting neck tissue displacement data, temperature field data and electromyographic signals in real time, and calculating spatial position variation of stellate ganglions and time-varying parameters of tissue electromagnetic characteristics; and modeling optimization: constructing a time-varying electromagnetic field distribution model based on the reference data, the spatial position variable quantity and the time-varying parameters. The method comprises the following steps: acquiring neck tissue displacement, a temperature field and an electromyographic signal in real time through reference data, capturing a stellate ganglion space position change and tissue electromagnetic property time-varying rule, constructing a time-varying electromagnetic field distribution model, and solving target stimulation parameters adaptive to a real-time tissue state through an optimal control algorithm.
Owner:河南医药大学第二附属医院(河南省精神病医院)

Endovascular implants and devices and methods for creating a percutaneous arteriovenous fistula

Various systems, devices, and methods for endovascular implants and accurate placement thereof are disclosed. The implants include a proximal implant segment, a distal implant segment, connector struts connecting the proximal implant segment to the distal implant segment, and a side opening between the proximal implant segment and the distal implant segment. The implants can be used to create an arteriovenous fistula or connect one vessel of the body to another by placement of the proximal implant segment and the distal implant segment within the vessels to be connected. The implants can have an hourglass shape. The implants can include a continuous strut or ring at a distal edge of the proximal implant segment. Also disclosed are methods for accurate percutaneous placement of the implants disclosed, and a device for percutaneous delivery.
Owner:VENOVA MEDICAL INC

Nerve regeneration system and method

A stimulation device includes an adaptor component. The adaptor component couples a percutaneous lead to the stimulation device. The stimulation device may apply a stimulation signal to target tissue via the adaptor. A surgeon may place the stimulation device in a container and the adaptor component may be disposed outside of the container. Methods describe prolonged stimulation of target tissue via a stimulation device. The prolonged stimulation may be applied during and after a surgical procedure.
Owner:CHECKPOINT SURGICAL LLC

Percutaneous targeting device

A percutaneous targeting device comprises a body holding an extension. The body has a target guide holding a target pin which may be a K-wire. The extension has two guide sleeves, holding a guide wire. All wires are held in a common plane. The guide wires serve as a guide for cannulated fixation screws. The extension is movable against the body to adjust the angle between the target pin and the guide wires.
Owner:ARTHREX INC

KGN-loaded nano-vesicle, soluble microneedle and preparation method and application of KGN-loaded nano-vesicle and soluble microneedle

The invention belongs to the technical field of biological medicine, and particularly relates to a KGN-loaded nano vesicle, a soluble microneedle and a preparation method and application of the KGN-loaded nano vesicle and the soluble microneedle. The preparation method comprises the following steps: loading KGN into mesenchymal stem cell membrane nano vesicles by adopting a co-extrusion method to obtain KGN-atNVs; and then integrating the KGN-NVs into the dissolvable microneedle by adopting a micro-molding method to obtain the KGN-NVs-loaded dissolvable microneedle. The soluble microneedle loaded with the KGN-atNVs can effectively reduce expression of inflammatory factors such as IL-1beta and TNF-alpha, reduce joint inflammation, protect a cartilage structure, promote cartilage repair and improve joint functions. According to the KGNN-NV delivery system based on the dissolvable microneedle, the immune regulation and drug delivery advantages of the mesenchymal stem cell membrane nanovesicles and the percutaneous delivery characteristic of the dissolvable microneedle can be synergistically exerted, and an innovative and practical solution is provided for clinical treatment of arthritis.
Owner:CHONGQING UNIVERSITY OF SCIENCE AND TECHNOLOGY