363 results about "Prosthetic valve" patented technology

A method can comprise deploying a prosthetic valve with a delivery apparatus, where the prosthetic valve comprises a frame and a rotatable screw connected to the frame, and where the screw comprises a screw head having an annular bore with internal threads. The delivery apparatus is releasably coupled to the screw and can comprise a first shaft and a first head disposed at an end of the first shaft, the first head comprising external threads releasably engaged with the internal threads of the screw head, and a second shaft that is coaxial with and surrounds the first shaft, the second shaft comprising a second head disposed at an end of the second shaft, the second head releasably engaged with an exterior surface of the screw head. Deploying the valve includes radially expanding the prosthetic valve by rotating the screw with the delivery apparatus.

A prosthetic valve includes a frame with inflow and outflow ends and a longitudinal axis extending therebetween. The frame is in a radially expanded state defining a radially expanded diameter and is configured to define a partially radially compressed diameter when the frame is in a partially radially compressed state. A sealing skirt coupled to the frame includes inflow and outflow end portions, an inelastic skirt portion with weft and warp threads, and a tensioning element extending circumferentially along the outflow end portion. The sealing skirt includes a terminal outflow edge configured to define a skirt diameter greater or equal to the partially radially compressed diameter and less than the radially expanded diameter when the sealing skirt is in a relaxed state. The weft and warp threads are configured to be oriented at an approximately 45-degree angle to the longitudinal axis when the sealing skirt is in the relaxed state.

The present invention discloses a prosthetic heart valve comprising at least two valve components, a sealant covering the valve components, and an edge-sealing structure. A space is formed between the valve components covered with the sealant. The edge-sealing structure has a closed end face and connects the ends of the sealant to form a closed space within the space. The prosthetic heart valve provided by the present invention can reduce the risk of thrombosis between the valve components. Because the edge-sealing structure is flexible, it has little effect on the compression and gripping of the prosthetic valve, and the addition of the edge-sealing structure does not affect the normal function of the prosthetic valve.

A prosthetic heart valves including an annular frame and one or more detachable outer skirts and methods associated therewith are disclosed. The frame includes a plurality of interconnected struts and one or more outer skirts releasably attached to an exterior surface of the frame. In some examples, an outer skirt is attached to the frame via at least one retaining suture formed by a plurality of stitches looped around a pull suture. Removal of the pull suture from the suture line enables the outer skirt and frame to separate as the stitches are pulled through openings in the outer skirt and remain attached to the frame. Removability of the outer skirt can facilitate improvements in implant and explant procedures of the prosthetic valves, such as, for example, valve-in-valve procedures.

A prosthetic valve includes a frame and a flow control component. The frame has an aperture extending through the frame about a central axis. The flow control component is mounted within the aperture and is configured to permit blood flow in a first direction approximately parallel to the vertical axis from an inflow end to an outflow end of the flow control component and to block blood flow in a second direction, opposite the first direction. The frame has an expanded configuration with a first height along the central axis, a first lateral width along a lateral axis perpendicular to the central axis, and a first longitudinal length along a longitudinal axis perpendicular to the central axis and the lateral axis. The frame has a compressed configuration with a second height less than the first height and a second lateral width less than the first lateral width.

A funnel crimper includes a body having a tapered portion, an extended outflow portion, and a tissue compressor. The tissue compressor is configured to apply a radially inward force to tissue of a prosthetic valve of a transcatheter heart valve prosthesis disposed on an inner surface of a frame of the transcatheter heart valve prosthesis as the transcatheter heart valve prosthesis is advanced through a lumen of the funnel crimper. The tissue compressor may be a ring of relatively soft material extending into the lumen of the funnel crimper or pressurized fluid applied radially inward to the lumen of the funnel crimper.

Embodiments of an implantable prosthetic valve are disclosed. The valve can have an annular frame having a plurality of frame members and a skirt assembly. The skirt assembly can include a laminate having a fabric layer sandwiched between a first covering member and a second covering member. At least one surface of the fabric layer can be exposed at one or more windows in the second covering member. The skirt assembly can be coupled to the annular frame by a suture extending through the fabric layer at the one or more windows and around at least one of the plurality of frame members. Methods for making such an implantable prosthetic valve are also disclosed.

The present invention relates to a radially collapsible frame (1) for a prosthetic valve, the frame (1) comprising an outflow end region (3) at a proximal end of the frame (1) and an inflow end region (2) at a distal end of the frame (1), opposite to the outflow end region (3). The frame (1) further includes at least two radially spaced commissure attachment regions 910, 10′, 10″) and a cell structure (30), composed of a plurality of lattice cells being arranged radially around a flow axis of the frame (1) and connecting the at least two commissure attachment regions (10, 10′, 10″). Finally, at least one anchoring / positioning arch (20, 20′, 20″) is provided, wherein said at least one anchoring / positioning arch (20, 20′, 20″) radially overlaps the cell structure (30) at least partially. In order to form the Inventive frame from as a single piece, the invention further relates to a method comprising bending the at least one anchoring / positioning arch (20, 20′, 20″) towards the cell structure (30) of the frame (1).

A valve frame includes a tubular portion defining a plurality of valve-frame coupling elements disposed circumferentially around a longitudinal axis of the valve frame, and a plurality of arms, extending radially outward from an upstream portion of the tubular portion to define an arm span, and configured to engage tissue in the atrium. An outer frame is coupled to the valve frame, and includes a ring circumscribing the tubular portion, and a plurality of flanges that extend radially outward from the ring to define a flange span, and are configured to engage ventricular tissue. Each arm defines a rigid portion and a flexible portion that is disposed radially outward from the rigid portion, and is more flexible than the rigid portion. The majority of the flexible portion is disposed further radially outward than the flange span. Other embodiments are also described.

An implant for implantation at a native atrioventricular valve of a subject, includes a frame assembly, including a valve frame and an outer frame coupled to each other. The valve frame includes a tubular portion that circumscribes a longitudinal axis of the valve frame so as to define a lumen along the axis, and an upstream support portion including a plurality of arms. Each arm extends radially outward from the tubular portion to engage tissue in the atrium. The outer frame includes a ring that circumscribes the tubular portion, and a plurality of ventricular anchors that extend radially outward from the ring and are configured to anchor the implant to tissue of the ventricle. In an expanded state of the frame assembly, the implant defines a toroidal space between the plurality of ventricular anchors and the upstream support portion. Other embodiments are also described.

Prosthetic ring valve assemblies are disclosed. A prosthetic valve ring assembly includes an outer tube and a plurality of anchors. The outer tube includes a plurality of windows. The plurality of anchors are positioned inside the outer tube and about a perimeter of the outer tube. The plurality of anchors are configured to be emitted from the plurality of windows in order to anchor the prosthetic valve ring assembly to annulus tissue of a patient.

A 3-D honeycomb textile can include a textured yarn. The textile can exhibit a heat-shrinkage rate from about 10% to about 60%. The textile can be configured to reversibly change its dimensions under application of stress. Prosthetic valves can have the disclosed textiles as a sealing member. Additionally, prosthetic valves can the disclosed textiles as cushion materials. In addition, methods of making the disclosed textiles and prosthetic valves are described.

The present disclosure relates to prosthetic valves and valvular structures thereof. In an example, a prosthetic valve can include a frame movable between a radially compressed configuration and a radially expanded configuration, and a valvular structure coupled to the frame. The valvular structure is a one-piece material that includes a plurality of integrally formed leaflets configured to regulate flow through the prosthetic valve, and at least one integral commissure fold continuously extending between two adjacent leaflets. The integral commissure fold is defined proximal to an intermediate slit of the valvular structure, and extends radially outwards through a window opening of the frame, forming a first commissure coupled to the frame.

A radially collapsible and expandable prosthetic heart valve is disclosed. A frame of the prosthetic valve can have radially offset commissure windows. In some examples, a plurality of commissure window elements includes at least one support post and a commissure window frame disposed radially inward from the adjacent cells of the valve frame.

The application provides a valve support and an artificial valve with the same, and belongs to the technical field of heart valves. The valve support comprises a support body, a positioning ring and an elastic connecting wire. The positioning ring is arranged in a compressed state and is adapted to be sequentially and serially arranged along an axis with the support body. When the positioning ring is elastically deformed from the compressed state to an expanded state, the positioning ring can be coaxially sleeved on the support body through the traction of the elastic connecting wire. After the valve support is implanted, the positioning ring can be self-expanded to the expanded state through elastic deformation and can be coaxially sleeved on the support body according to the traction of the elastic connecting wire. Therefore, the positioning ring and the support body can be simultaneously positioned during the implantation operation. Due to the traction of the connecting wire, the support body can be self-positioned according to the positioning ring, thereby saving the separate positioning operation of the positioning ring and the support body and making the operation more convenient.

A percutaneous delivery tool includes a shaft, and proximal and distal capsules which move axially with respect to the shaft. A prosthetic valve includes a tubular portion, an upstream support portion extending therefrom and a plurality of flanges each having a respective flange end-portion. The prosthetic valve is restrainable by the delivery tool, such that the shaft and a downstream end of the tubular portion are disposed within the distal capsule, and the upstream support portion and the flange end-portions are disposed within the proximal capsule. Other embodiments are also described.

A prosthetic valve includes an annular frame and a valvular structure mounted within the annular frame. The valvular structure comprises a plurality of leaflets and a plurality of offset elements. Each leaflet includes a leaflet free edge that is offset in an axial direction from the commissures by upper material portions that are unattached to the frame. Commissures are formed by primary tabs on the side edges of adjacent leaflets attached to secondary tabs on opposing ends of the offset elements. A bridge portion of the offset elements extends over an end portion of the leaflet free edges of the adjacent leaflets and is moveable between a neutral position and a radially outward shifted position. An articulation axis between the adjacent leaflets is offset greater distance from the frame when the bridge portion is in the neutral position relative to when the bridge portion is in the radially outward shifted position.

Embodiments of a prosthetic valve delivery apparatus are disclosed. The delivery apparatus includes a first portion configured to maintain a fixed spatial relationship relative to a first end of the prosthetic valve and a second portion configured to maintain a fixed spatial relationship relative to a second end of the prosthetic valve during radial expansion of the prosthetic valve. The first portion includes one or more reference radiopaque markers and the second portion includes an indicator radiopaque marker. A position of the indicator radiopaque marker relative to the one or more reference radiopaque markers measures an axial distance between the first and second ends of the prosthetic valve indicative of a corresponding diameter of the prosthetic valve as it is radially expanded from a radially compressed state to a radially expanded state.

A medical assembly can include a radially expandable prosthetic heart valve and a delivery apparatus. The delivery apparatus can include a handle, an actuation member, and a force limiting mechanism within the handle including a pivot arm coupled to a base portion. The actuation member can apply a proximally directed force to the prosthetic valve to cause the valve to expand. The actuation member can be coupled to the pivot arm such that a force applied to the actuation member causes the pivot arm to pivot. The force limiting mechanism can pinch the actuation member between the pivot arm and the base portion when the force applied to the actuation member exceeds a predetermined force to prevent proximal movement of the actuation member and can allow proximal movement of the actuation member to produce radial expansion of the prosthetic valve when the force applied is less than the predetermined force.

Apparatuses, systems, and methods for prosthetic valves having sensor systems are disclosed. Examples of prosthetic valves include replacement heart valves for replacing the function of a native heart valve, such as a mitral or tricuspid valve. In various embodiments, replacement heart valves are provided with sensors or markers for assisting with proper placement and / or securement in the body. A replacement heart valve may include anchors for securing the replacement heart valve to native leaflets, wherein sensors and / or markers provide feedback to the physician for confirming proper placement of the anchors during the implantation procedure. Sensors may also be used to assess the function of the prosthetic valve after deployment. Sensors may also be used to monitor blood pressure, temperature, oxygen, insulin, cholesterol, and / or glucose to assess overall patient health.

A prosthetic valve includes a radially expandable and compressible frame, a leaflet assembly comprising a plurality of leaflets coupled to the frame, and an outer skirt positioned around an outer surface of the frame. The outer skirt includes a tissue layer and a non-tissue layer. The tissue layer has a fibrous side and a smooth side. The non-tissue layer is coupled to the smooth side of the tissue layer. The outer skirt is positioned so that the fibrous side of the tissue layer faces away from the frame and the non-tissue layer faces towards the frame.

A prosthesis includes a frame and a skirt coupled to a surface of the frame. The skirt extends over at least one side opening of a plurality of side openings of the frame. The prosthesis also includes a skirt-reinforcement member that spans the at least one side opening from a first crown or strut edge defining the at least one side opening to a second crown or strut edge defining the at least one side opening. The skirt-reinforcement member has a first end, a second end, and a length therebetween. The first end of the skirt-reinforcement member is attached to the first crown or strut edge and the second end of the skirt-reinforcement member is attached to the second crown or strut edge. The skirt-reinforcement member is attached to the skirt along an unsupported portion of the skirt that spans the at least one side opening.

Apparatus and methods are described including a valve frame configured to support a prosthetic valve within a native atrio-ventricular valve. The valve frame includes an atrial part comprising a disc-shaped portion configured to be deployed on an atrial side of the valve annulus, and a frustoconical portion, and a cylindrical part to which the prosthetic valve leaflets are coupled. The cylindrical part configured to be deployed such that a ventricular end of the cylindrical part is disposed within the ventricle. A plurality of protruding struts are configured to protrude from outside the cylindrical part, the frustoconical portion of the atrial part being coupled to the cylindrical part via the protruding struts. Other applications are also described.

The present disclosure relates to prosthetic valves that can be expanded to selected maximal diameters. In an example, a prosthetic valve assembly comprises a prosthetic valve having an annular frame, one or more expansion control rods disposed radially outward to the frame, and one or more flexible tension members extending circumferentially around the frame, and comprising one or more local loops wrapped around the corresponding expansion control rods. The flexible tension member is configured to radially expand to a first diameter when all local loops are wrapped around the corresponding expansion control rods, and expand to a second diameter greater than the first diameter, when one of the expansion control rod is retracted from the flexible tension member, thereby allowing the corresponding local loop to unravel.

A delivery apparatus configured to deliver a prosthetic valve can include a handle, a first shaft extending distally from the handle, a second shaft extending through a lumen of the first shaft, a nose cone mounted on a distal end portion of the second shaft, a balloon mounted along the distal end portion of the second shaft, and a first pull wire extending longitudinally along the second shaft. A distal end of the first pull wire is fixed relative to the second shaft at a location that is distal to a distal end of the balloon. Tension in the first pull wire can be adjusted to adjust a curvature of the distal end portion of the second shaft and the nose cone.

Provided is a prosthetic valve replacement system. A hoop member is at least partially disposed on a valve clamping mechanism. A valve clamping and securing mechanism is configured to present a first form and a second form, and the second form is present after the first form. When the valve clamping and securing apparatus is in the first form, the valve clamping mechanism is configured to capture and clamp autologous valve leaflets. After the radial expansion of a valve stent, the valve clamping and securing apparatus is in the second form.

A prosthetic heart valve comprising a radially expandable and compressible frame and a plurality of leaflets is disclosed. The frame comprises a plurality of rows of angled frame elements and a plurality of axially extending commissure support portions spaced apart from each other around a circumference of the frame and defining first and second slots. The plurality of leaflets each comprise a leaflet attachment region defining opposing attachment portions on opposite sides of the leaflet. At each commissure support portion of the frame, an attachment portion of one of the leaflets extends through the first slot and an attachment portion of an adjacent leaflet extends through the second slot.

A mounting assembly for crimping a prosthetic valve onto a valve mounting portion of a delivery apparatus is disclosed. The mounting assembly includes a coupling member configured to releasably couple to a crimping device, the coupling member comprising a lumen, and a valve support member configured to be inserted into the prosthetic valve so that leaflets of the prosthetic valve contact and rest upon a support surface of the valve support member. The valve support member can be axially movable relative to the coupling member through the lumen of the coupling member.

A device and method of inhibiting and preventing damage to leaflets during the crimping of a prosthetic valve, and / or facilitating the folding of the leaflets during the crimping of a prosthetic valve.

Disclosed are an artificial valve delivery device and a delivery locating method. The artificial valve delivery device comprises: an outer tube; a catheter arranged in the outer tube, wherein a space capable of accommodating an artificial valve is formed between the outer tube and the catheter, and the outer tube and the catheter can move relative to each other in an axis direction thereof; and a marking piece, wherein the marking piece is arranged on the catheter and located at a position corresponding to a position where the artificial valve is located, and is configured to be capable of being detected by an ultrasonic detection device when the artificial valve is unfolded in an implantation process of the artificial valve. By arranging the marking piece at the position where the artificial valve is loaded on the delivery device, the position and the angle of the artificial valve in the unfolded state can be accurately located through the ultrasonic detection device according to the characteristics of the marking piece on an ultrasonic image, thereby solving the problem that it is difficult to accurately locate the position of the artificial valve after being unfolded.